Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionryanodine-sensitive calcium-release channel activity

RYR1 RYR2 RYR3

2.03e-074753GO:0005219
GeneOntologyMolecularFunctioncalcium-induced calcium release activity

RYR1 RYR2 RYR3

1.01e-066753GO:0048763
GeneOntologyMolecularFunctioncalcium channel activity

TMC2 SLC24A4 PKD2L1 RYR1 RYR2 RYR3

9.04e-06129756GO:0005262
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

TMC2 SLC24A4 PKD2L1 RYR1 RYR2 RYR3

2.22e-05151756GO:0015085
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

RYR1 RYR2 RYR3

3.99e-0518753GO:0015278
GeneOntologyMolecularFunctionprotein kinase A regulatory subunit binding

ARFGEF2 ARFGEF1 RYR2

1.10e-0425753GO:0034237
GeneOntologyMolecularFunctionligand-gated calcium channel activity

RYR1 RYR2 RYR3

2.12e-0431753GO:0099604
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

RYR1 RYR2 RYR3

2.56e-0433753GO:0005217
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

FBN1 FBN2

8.97e-0412752GO:0030023
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

FBN1 FBN2

1.23e-0314752GO:0097493
GeneOntologyMolecularFunctionprotein kinase A binding

ARFGEF2 ARFGEF1 RYR2

1.35e-0358753GO:0051018
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

ATP7A TMC2 SLC24A4 PKD2L1 RYR1 RYR2 RYR3

1.80e-03465757GO:0046873
GeneOntologyMolecularFunctionmonoatomic cation channel activity

TMC2 SLC24A4 PKD2L1 RYR1 RYR2 RYR3

1.83e-03343756GO:0005261
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

PKD2L1 RYR1 RYR2 RYR3

1.91e-03140754GO:0099094
GeneOntologyMolecularFunctioncalcium ion binding

STAB2 FBN1 FBN2 DSG3 PKD2L1 EFCAB14 RYR1 RYR2 RYR3

1.93e-03749759GO:0005509
GeneOntologyBiologicalProcesscellular response to caffeine

RYR1 RYR2 RYR3

8.08e-0611773GO:0071313
GeneOntologyBiologicalProcesscellular response to purine-containing compound

RYR1 RYR2 RYR3

1.77e-0514773GO:0071415
GeneOntologyBiologicalProcessresponse to caffeine

RYR1 RYR2 RYR3

6.34e-0521773GO:0031000
GeneOntologyBiologicalProcessmetal ion transport

ATP7A TMC2 MS4A2 NKAIN4 SLC24A4 PKD2L1 NKAIN1 NKAIN3 PLP1 RYR1 RYR2 AMIGO1 RYR3

7.75e-0510007713GO:0030001
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

FBN1 FBN2

8.21e-054772GO:0035583
GeneOntologyBiologicalProcessregulation of metal ion transport

ATP7A TMC2 MS4A2 NKAIN4 NKAIN1 NKAIN3 PLP1 RYR2 AMIGO1

9.03e-05493779GO:0010959
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

TMC2 MS4A2 SLC24A4 PKD2L1 PLP1 RYR1 RYR2 RYR3

1.06e-04392778GO:0070588
GeneOntologyBiologicalProcessmaintenance of location

HDAC3 FBN1 FBN2 MS4A2 PLIN5 RYR1 RYR2 RYR3

1.14e-04396778GO:0051235
GeneOntologyBiologicalProcessaxon ensheathment in central nervous system

MAG FGFR3 PLP1

2.52e-0433773GO:0032291
GeneOntologyBiologicalProcesscentral nervous system myelination

MAG FGFR3 PLP1

2.52e-0433773GO:0022010
GeneOntologyBiologicalProcessregulation of monoatomic ion transport

ATP7A TMC2 MS4A2 NKAIN4 NKAIN1 NKAIN3 PLP1 RYR2 AMIGO1

2.93e-04577779GO:0043269
GeneOntologyBiologicalProcessmonoatomic cation transport

ATP7A TMC2 MS4A2 NKAIN4 SLC24A4 PKD2L1 NKAIN1 NKAIN3 PLP1 RYR1 RYR2 AMIGO1 RYR3

3.27e-0411577713GO:0006812
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum

RYR1 RYR2 RYR3

3.55e-0437773GO:0014808
GeneOntologyBiologicalProcessmaintenance of protein location in extracellular region

FBN1 FBN2

3.80e-048772GO:0071694
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by endoplasmic reticulum

RYR1 RYR2 RYR3

4.15e-0439773GO:1903514
GeneOntologyCellularComponentcalcium channel complex

PKD2L1 RYR1 RYR2 RYR3

1.53e-0473774GO:0034704
GeneOntologyCellularComponentjunctional membrane complex

RYR1 RYR3

4.74e-049772GO:0030314
GeneOntologyCellularComponentjunctional sarcoplasmic reticulum membrane

RYR1 RYR2

5.91e-0410772GO:0014701
GeneOntologyCellularComponentsarcoplasmic reticulum membrane

RYR1 RYR2 RYR3

6.10e-0445773GO:0033017
GeneOntologyCellularComponentsmooth endoplasmic reticulum

RYR1 RYR2 RYR3

6.51e-0446773GO:0005790
GeneOntologyCellularComponentmicrofibril

FBN1 FBN2

1.02e-0313772GO:0001527
DomainRyanrecept_TM4-6

RYR1 RYR2 RYR3

5.73e-083733IPR009460
DomainRyR

RYR1 RYR2 RYR3

5.73e-083733PF02026
DomainRyanodine_rcpt

RYR1 RYR2 RYR3

5.73e-083733IPR003032
DomainRR_TM4-6

RYR1 RYR2 RYR3

5.73e-083733PF06459
DomainRyan_recept

RYR1 RYR2 RYR3

5.73e-083733IPR013333
DomainNKAIN

NKAIN4 NKAIN1 NKAIN3

2.29e-074733PF05640
DomainNa/K-Atpase_Interacting

NKAIN4 NKAIN1 NKAIN3

2.29e-074733IPR008516
DomainRIH_assoc

RYR1 RYR2 RYR3

1.14e-066733PF08454
DomainRIH_assoc-dom

RYR1 RYR2 RYR3

1.14e-066733IPR013662
DomainRIH_dom

RYR1 RYR2 RYR3

1.14e-066733IPR000699
DomainIns145_P3_rcpt

RYR1 RYR2 RYR3

1.14e-066733IPR014821
DomainRyanodine_recept-rel

RYR1 RYR2 RYR3

1.14e-066733IPR015925
Domain-

RYR1 RYR2 RYR3

1.14e-0667331.25.10.30
DomainRYDR_ITPR

RYR1 RYR2 RYR3

1.14e-066733PF01365
DomainIns145_P3_rec

RYR1 RYR2 RYR3

1.14e-066733PF08709
DomainMIR

RYR1 RYR2 RYR3

6.74e-0610733PS50919
DomainMIR

RYR1 RYR2 RYR3

6.74e-0610733PF02815
DomainMIR

RYR1 RYR2 RYR3

6.74e-0610733SM00472
DomainMIR_motif

RYR1 RYR2 RYR3

6.74e-0610733IPR016093
DomainFBN

FBN1 FBN2

4.51e-053732IPR011398
DomainARM-type_fold

FOCAD STK36 ARFGEF2 ARFGEF1 USP35 RALGAPA2 RYR3 KPNB1

5.22e-05339738IPR016024
DomainDUF1981

ARFGEF2 ARFGEF1

9.00e-054732PF09324
DomainSec7_N

ARFGEF2 ARFGEF1

9.00e-054732IPR032691
DomainSec7_N

ARFGEF2 ARFGEF1

9.00e-054732PF12783
DomainDCB_dom

ARFGEF2 ARFGEF1

9.00e-054732IPR032629
DomainDCB

ARFGEF2 ARFGEF1

9.00e-054732PF16213
DomainSec7_C

ARFGEF2 ARFGEF1

9.00e-054732IPR015403
DomainTB

FBN1 FBN2

3.12e-047732PF00683
DomainSPRY

RFPL2 RYR1 RYR2 RYR3

3.74e-0487734SM00449
Domain-

FBN1 FBN2

4.16e-0487323.90.290.10
DomainSPRY

RFPL2 RYR1 RYR2 RYR3

5.02e-0494734PF00622
DomainSPRY_dom

RFPL2 RYR1 RYR2 RYR3

5.02e-0494734IPR003877
DomainB30.2/SPRY

RFPL2 RYR1 RYR2 RYR3

5.23e-0495734IPR001870
DomainB302_SPRY

RFPL2 RYR1 RYR2 RYR3

5.23e-0495734PS50188
DomainTB

FBN1 FBN2

5.33e-049732PS51364
DomainTB_dom

FBN1 FBN2

5.33e-049732IPR017878
DomainEF-hand-dom_pair

CCAR1 PKD2L1 EFCAB14 RYR1 RYR2 RYR3

8.98e-04287736IPR011992
Domain-

ARFGEF2 ARFGEF1

1.53e-03157321.10.1000.11
DomainSec7

ARFGEF2 ARFGEF1

1.53e-0315732PF01369
DomainSec7_alpha_orthog

ARFGEF2 ARFGEF1

1.53e-0315732IPR023394
DomainSec7

ARFGEF2 ARFGEF1

1.75e-0316732SM00222
DomainSEC7

ARFGEF2 ARFGEF1

1.75e-0316732PS50190
DomainSec7_dom

ARFGEF2 ARFGEF1

1.75e-0316732IPR000904
DomainEF_hand_dom

PKD2L1 EFCAB14 RYR1 RYR2 RYR3

2.14e-03232735IPR002048
Domain-

PKD2L1 EFCAB14 RYR1 RYR2 RYR3

3.56e-032617351.10.238.10
DomainARM-like

STK36 ARFGEF2 ARFGEF1 USP35 KPNB1

4.11e-03270735IPR011989
DomaincEGF

FBN1 FBN2

4.61e-0326732IPR026823
DomaincEGF

FBN1 FBN2

4.61e-0326732PF12662
DomainIg_I-set

MAG FGFR3 LRIT3 AMIGO1

6.54e-03190734IPR013098
Domainig

MAG FGFR3 IGSF1 AMIGO1

6.54e-03190734PF00047
DomainImmunoglobulin

MAG FGFR3 IGSF1 AMIGO1

6.54e-03190734IPR013151
DomainI-set

MAG FGFR3 LRIT3 AMIGO1

6.54e-03190734PF07679
Domain-

ATP8B3 ATP7A

6.93e-03327323.40.1110.10
Domain-

ATP8B3 ATP7A

6.93e-03327322.70.150.10
DomainEF-hand_8

RYR1 RYR2

7.80e-0334732PF13833
DomainATPase_P-typ_cyto_domN

ATP8B3 ATP7A

8.25e-0335732IPR023299
DomainP_typ_ATPase

ATP8B3 ATP7A

8.71e-0336732IPR001757
DomainATPase_P-typ_P_site

ATP8B3 ATP7A

8.71e-0336732IPR018303
DomainATPASE_E1_E2

ATP8B3 ATP7A

8.71e-0336732PS00154
DomainATPase_P-typ_transduc_dom_A

ATP8B3 ATP7A

9.19e-0337732IPR008250
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

RYR1 RYR2 RYR3

7.21e-0611513M47958
PathwayWP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING

RYR1 RYR2 RYR3

1.24e-0513513M39589
PathwayBIOCARTA_ARAP_PATHWAY

ARFGEF2 ARFGEF1 ARAP1

2.93e-0517513M2482
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

RYR1 RYR2 RYR3

4.15e-0519513M47760
PathwayWP_GLIAL_CELL_DIFFERENTIATION

MAG PLP1

3.54e-048512M39372
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ATP8B3 ATP7A RYR1 RYR2 RYR3

4.23e-04176515MM15718
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ATP8B3 ATP7A RYR1 RYR2 RYR3

5.05e-04183515M997
Pubmed

Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.

RYR1 RYR2 RYR3

1.04e-08377318403125
Pubmed

Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.

RYR1 RYR2 RYR3

1.04e-08377318434746
Pubmed

SPRY domains in ryanodine receptors (Ca(2+)-release channels).

RYR1 RYR2 RYR3

1.04e-0837739204703
Pubmed

The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.

RYR1 RYR2 RYR3

1.04e-0837737876312
Pubmed

Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.

RYR1 RYR2 RYR3

1.04e-08377321881589
Pubmed

Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).

RYR1 RYR2 RYR3

1.04e-08377312213830
Pubmed

Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.

RYR1 RYR2 RYR3

1.04e-0837739242641
Pubmed

Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.

RYR1 RYR2 RYR3

1.04e-08377322948152
Pubmed

Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.

RYR1 RYR2 RYR3

1.04e-08377310788707
Pubmed

Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.

RYR1 RYR2 RYR3

1.04e-08377325239916
Pubmed

Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.

RYR1 RYR2 RYR3

1.04e-0837737621815
Pubmed

A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.

RYR1 RYR2 RYR3

1.04e-08377318643873
Pubmed

Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).

RYR1 RYR2 RYR3

1.04e-08377311159936
Pubmed

Molecular identification of the ryanodine receptor pore-forming segment.

RYR1 RYR2 RYR3

1.04e-08377310473538
Pubmed

Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.

RYR1 RYR2 RYR3

1.04e-0837737959768
Pubmed

The organization of proteins in the human red blood cell membrane. A review.

RYR1 RYR2 RYR3

1.04e-0837734600883
Pubmed

Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.

RYR1 RYR2 RYR3

1.04e-0837737635066
Pubmed

A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.

RYR1 RYR2 RYR3

4.17e-08477318206662
Pubmed

Ryanodine receptor calcium release channels: lessons from structure-function studies.

RYR1 RYR2 RYR3

4.17e-08477323413940
Pubmed

Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.

RYR1 RYR2 RYR3

4.17e-0847739384575
Pubmed

Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.

RYR1 RYR2 RYR3

4.17e-0847739607712
Pubmed

Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.

RYR1 RYR2 RYR3

4.17e-08477323482488
Pubmed

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.

RYR1 RYR2 RYR3

1.04e-07577323918386
Pubmed

Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.

RYR1 RYR2 RYR3

1.04e-07577319011160
Pubmed

Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.

RYR1 RYR2 RYR3

2.08e-07677319549818
Pubmed

Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.

RYR1 RYR2 RYR3

2.08e-07677326025922
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

RYR1 RYR2 RYR3

2.08e-07677323463619
Pubmed

FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.

RYR1 RYR2 RYR3

2.08e-07677314592808
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

RYR1 RYR2 RYR3

2.08e-07677320519450
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

RYR1 RYR2 RYR3

2.08e-07677325966694
Pubmed

HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.

RYR1 RYR2 RYR3

2.08e-07677319009018
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

RYR1 RYR2 RYR3

2.08e-07677316844763
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

RYR1 RYR2 RYR3

3.63e-07777311860456
Pubmed

A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase.

NKAIN4 NKAIN1 NKAIN3

3.63e-07777317606467
Pubmed

Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.

RYR1 RYR2 RYR3

3.63e-07777320962236
Pubmed

Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.

RYR1 RYR2 RYR3

5.80e-07877319033399
Pubmed

Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.

RYR1 RYR2 RYR3

5.80e-07877311784029
Pubmed

New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.

RYR1 RYR2 RYR3

2.26e-061277319095005
Pubmed

Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.

FBN1 FBN2

4.84e-06277212399449
Pubmed

Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.

FBN1 FBN2

4.84e-06277221851253
Pubmed

Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.

FBN1 FBN2

4.84e-06277212429739
Pubmed

New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.

FBN1 FBN2

4.84e-06277230044367
Pubmed

Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.

FBN1 FBN2

4.84e-06277221440062
Pubmed

MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.

FBN1 FBN2

4.84e-06277215131124
Pubmed

Focused ion beam-scanning electron microscopy links pathological myelin outfoldings to axonal changes in mice lacking Plp1 or Mag.

MAG PLP1

4.84e-06277236354016
Pubmed

Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.

RYR2 RYR3

4.84e-06277221531043
Pubmed

Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells.

RYR2 RYR3

4.84e-06277216678258
Pubmed

Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.

FBN1 FBN2

4.84e-06277212524050
Pubmed

Microfibril structure masks fibrillin-2 in postnatal tissues.

FBN1 FBN2

4.84e-06277220404337
Pubmed

Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region of the RYR1 gene.

RYR1 RYR3

4.84e-06277212565913
Pubmed

Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors.

RYR1 RYR3

4.84e-0627729489997
Pubmed

Fibrillln mutations in Marfan syndrome and related phenotypes.

FBN1 FBN2

4.84e-0627728791520
Pubmed

Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.

RYR1 RYR2

4.84e-06277217259277
Pubmed

Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors.

RYR1 RYR3

4.84e-0627729192302
Pubmed

The block of ryanodine receptors selectively inhibits fetal myoblast differentiation.

RYR1 RYR3

4.84e-06277212640042
Pubmed

Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.

FBN1 FBN2

4.84e-0627728120105
Pubmed

The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.

FBN1 FBN2

4.84e-06277235419902
Pubmed

Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.

FBN1 FBN2

4.84e-0627728307578
Pubmed

Ryanodine receptor oligomeric interaction: identification of a putative binding region.

RYR1 RYR2

4.84e-06277214722100
Pubmed

Fibrillin assembly: dimer formation mediated by amino-terminal sequences.

FBN1 FBN2

4.84e-06277210504303
Pubmed

Structural and functional interactions within ryanodine receptor.

RYR1 RYR2

4.84e-06277226009179
Pubmed

Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle.

RYR1 RYR3

4.84e-0627727556644
Pubmed

Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.

RYR1 RYR2

4.84e-06277232899693
Pubmed

Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion.

RYR1 RYR3

4.84e-06277214592949
Pubmed

Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.

FBN1 FBN2

4.84e-0627727744963
Pubmed

Fibrillin microfibrils in bone physiology.

FBN1 FBN2

4.84e-06277226408953
Pubmed

Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.

ARFGEF2 ARFGEF1

4.84e-06277223918382
Pubmed

Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA.

RYR2 RYR3

4.84e-0627728898078
Pubmed

Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.

FBN1 FBN2

4.84e-06277218006876
Pubmed

Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.

RYR1 RYR3

4.84e-06277215894801
Pubmed

Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.

RYR1 RYR2

4.84e-06277230542613
Pubmed

Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.

FBN1 FBN2

4.84e-06277224833718
Pubmed

Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.

ARFGEF2 ARFGEF1

4.84e-06277217360629
Pubmed

The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.

RYR2 RYR3

4.84e-06277214550562
Pubmed

Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.

ARFGEF2 ARFGEF1

4.84e-06277210716990
Pubmed

Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.

RYR1 RYR2

4.84e-06277215280431
Pubmed

Expression of the ryanodine receptor isoforms in immune cells.

RYR1 RYR2

4.84e-06277211673493
Pubmed

B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.

RYR1 RYR2

4.84e-06277211673462
Pubmed

Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors.

RYR1 RYR3

4.84e-0627729799464
Pubmed

Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.

FBN1 FBN2

4.84e-06277224265020
Pubmed

Membrane association of the Arabidopsis ARF exchange factor GNOM involves interaction of conserved domains.

ARFGEF2 ARFGEF1

4.84e-06277218203920
Pubmed

In vivo studies of mutant fibrillin-1 microfibrils.

FBN1 FBN2

4.84e-06277220529844
Pubmed

Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.

FBN1 FBN2

4.84e-06277225524144
Pubmed

Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3.

RYR1 RYR3

4.84e-0627729817784
Pubmed

Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.

FBN1 FBN2

4.84e-06277223133647
Pubmed

Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.

RYR1 RYR2

4.84e-06277225370123
Pubmed

Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.

ARFGEF2 ARFGEF1

4.84e-06277210212200
Pubmed

Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes.

RYR2 RYR3

4.84e-06277214985349
Pubmed

Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.

RYR1 RYR2

4.84e-06277215033925
Pubmed

Fibrillins 1 and 2 perform partially overlapping functions during aortic development.

FBN1 FBN2

4.84e-06277216407178
Pubmed

Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.

FBN1 FBN2

4.84e-0627721852206
Pubmed

Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.

RYR1 RYR2

4.84e-06277218618700
Pubmed

N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.

FBN1 FBN2

4.84e-06277210359653
Pubmed

Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development.

RYR1 RYR3

4.84e-06277217118445
Pubmed

Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.

ARFGEF2 ARFGEF1

4.84e-06277218417613
Pubmed

[Identification of novel metastasis associated genes MAG-1 and MAG-2].

RETREG2 GPAT3

4.84e-06277221310131
Pubmed

RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle.

RYR1 RYR3

4.84e-06277211500519
Pubmed

Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.

FBN1 FBN2

1.45e-05377210825173
Pubmed

Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor.

RYR1 RYR3

1.45e-05377211171121
Pubmed

Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity.

ARFGEF2 ARFGEF1

1.45e-05377219332778
GeneFamilyRyanodine receptors|Protein phosphatase 1 regulatory subunits

RYR1 RYR2 RYR3

2.66e-083553287
GeneFamilyNa+/K+ transporting ATPase interacting

NKAIN4 NKAIN1 NKAIN3

1.06e-074553659
CoexpressionAtlasdev gonad_e11.5_M_GonadVasMes_Flk_k-means-cluster#1_top-relative-expression-ranked_1000

FBN1 FBN2 ATP7A TM4SF5 GXYLT1 PLAT THSD7B RECK

1.49e-05337708gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_k1_1000
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O2|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 PKD2L1 NKAIN1 DEFB109B PLP1

1.80e-08977767b17dc28454949a23701ab127300a29a8899d7d6
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O2-Tfr|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 PKD2L1 NKAIN1 DEFB109B PLP1

1.80e-08977764b74b3c5b9590a8215b7370b37e9723e9f040b9c
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE-O2|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 PKD2L1 NKAIN1 DEFB109B PLP1

7.11e-08122776d4152c45dfbb979ddf8380b4896db753a79cad9e
ToppCellFrontal_cortex-Macroglia-OLIGODENDROCYTE-O2|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 PKD2L1 NKAIN1 DEFB109B PLP1

7.11e-081227762880f25d10a7765e55a2aa20c7a6ef74cea19c4d
ToppCellFrontal_cortex-Macroglia-OLIGODENDROCYTE|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 PKD2L1 NKAIN1 DEFB109B PLP1

7.11e-08122776ecd0e54dd829201290212ea2ff7c8e7eec19c0e9
ToppCellFrontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 PKD2L1 NKAIN1 DEFB109B PLP1

7.11e-08122776cffd7730bda90828efc0def452cabb44cf93ab48
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE-O2-Trf|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 PKD2L1 NKAIN1 DEFB109B PLP1

7.11e-0812277640f983623c990203df4ba997e296231489d51012
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 PKD2L1 NKAIN1 DEFB109B PLP1

7.84e-081247769f169fa17be1842a6bd83778ff30465a740edd5f
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE|Hippocampus / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 PKD2L1 NKAIN1 DEFB109B PLP1

1.42e-071377765e97480f014f1d9267e8126f1d0e58acd22f36aa
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CLDN14 TMC2 NKAIN4 NKAIN1 NKAIN3 PLP1

4.72e-07168776948d9e9972bd2a4b503d55fa69b70dd568a35a67
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 FBN2 NKAIN4 UPK1B CHRDL1 PLAT

8.83e-071877764e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 FBN2 NKAIN4 UPK1B CHRDL1 PLAT

8.83e-07187776d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 FBN2 NKAIN4 UPK1B CHRDL1 PLAT

8.83e-07187776827eae63fabf6892a82ce7779b5f395958d3d628
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 NKAIN4 UPK1B SHISA2 FGFR3 ARAP1

1.13e-061957761c1135be421af98cd0077bec1ff2c4158d42aa21
ToppCellPND10-Mesenchymal-Mesenchymal_structural|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 NKAIN4 UPK1B SHISA2 FGFR3 ARAP1

1.13e-0619577611d421bbbb71425d59cbdd673e052e00d5f0a768
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 NKAIN4 UPK1B SHISA2 FGFR3 ARAP1

1.13e-061957761f005ee1da66b539bd200aaa98f46edbbc7f12e4
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 NKAIN4 UPK1B SHISA2 FGFR3 ARAP1

1.13e-0619577610f307aef8f4d9e71c501d5bcedb84d3be7a4d1b
ToppCellSubstantia_nigra-Macroglia-OLIGODENDROCYTE|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CLDN14 PKD2L1 NKAIN1 DEFB109B PLP1

1.43e-061117754a22732094a9781867d501d9c05ba652c2f25048
ToppCellCerebellum-Macroglia-OLIGODENDROCYTE|Cerebellum / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 PKD2L1 DEFB109B PLP1

1.71e-0611577515b2c11225802cc15c01165d84a755432f02d82f
ToppCellThalamus-Macroglia-OLIGODENDROCYTE|Thalamus / BrainAtlas - Mouse McCarroll V32

CLDN14 PKD2L1 NKAIN1 DEFB109B PLP1

3.00e-06129775b3cb0c10659d1216b8f7de3aa1f9aac101cb65dd
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

MAG PKD2L1 NKAIN1 DEFB109B PLP1

3.00e-0612977598a5f24de72d2ae6a57787226b2e523ddd13b2c5
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE-O2-Trf|Hippocampus / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 PKD2L1 DEFB109B PLP1

3.36e-06132775dc6edfa821a1cdc645668b0af5ba5ff80dee10bd
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE-O2|Hippocampus / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 PKD2L1 DEFB109B PLP1

3.36e-0613277560ced08bda5efc95a6f116cd0c6d1a779d99ed38
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O1-Tfr|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CLDN14 PKD2L1 NKAIN1 DEFB109B

6.67e-0670774b159435487b90331d2d276f182fc8aedf88d612c
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O1-Tfr-Oligodendrocyte.Tfr.Il33_(Il33)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CLDN14 PKD2L1 NKAIN1 DEFB109B

6.67e-06707747e09547b73789d789c3c464689f7998445830238
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O1|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CLDN14 PKD2L1 NKAIN1 DEFB109B

6.67e-0670774b486f7fe68743e3385809cfd64512da2f31074df
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O1-Tfr-Oligodendrocyte.Tfr.Il33_(Il33)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CLDN14 PKD2L1 NKAIN1 DEFB109B

6.67e-06707748ee9c9c78eec9dc0cec364ee7c9bc6f34d37de76
ToppCellChildren_(3_yrs)-Immune-mast_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

MS4A2 GPAT3 PLAT THSD7B RYR3

6.91e-06153775d3fb83ca984c7583b1e51c364be6c7c17f67b048
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP8B3 STAB2 TMC2 PKD2L1 ELFN2

8.08e-06158775f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP8B3 STAB2 TMC2 PKD2L1 ELFN2

8.08e-061587758c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O2-Tfr-Oligodendrocyte.Tfr.Sez6_(Sez6)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CLDN14 PKD2L1 NKAIN1 DEFB109B

9.26e-06767742b1d7bafad3d9a01fc47790418160950330576c5
ToppCellPosterior_cortex-Macroglia-OLIGODENDROCYTE-O2-Tfr-Oligodendrocyte.Tfr.Sez6_(Sez6)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

CLDN14 PKD2L1 NKAIN1 DEFB109B

9.26e-0676774322c3a4c3abdc419f162861ecd52c0ad6ef2381c
ToppCell-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

NLRP11 CLDN14 FBN1 CHRDL1 NKAIN3

1.03e-05166775bc9323de1373fdc0357e6bb46874f6c4787443a9
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Plin3_(Plin3)|Hippocampus / BrainAtlas - Mouse McCarroll V32

CLDN14 PKD2L1 DEFB109B PLP1

1.14e-05807740d5770c81a223148e57d625ac2c2ae69ab55b36e
ToppCellHippocampus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Plin3_(Plin3)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

CLDN14 PKD2L1 DEFB109B PLP1

1.14e-0580774413796630e7aeff7c68a69dd2d9b8cd8f56163b4
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NKAIN4 UPK1B TM4SF5 CHRDL1 NKAIN3

1.25e-05173775ee7d1429f23f1b89a9a9f7bc07a84a44cf7acd1c
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NKAIN4 UPK1B TM4SF5 CHRDL1 NKAIN3

1.25e-051737753725525b99a6011eda2ff5459b4fd2e1eab1f090
ToppCellEndothelial-B-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

STAB2 NKAIN4 CHRDL1 PLAT RECK

1.25e-05173775a81992965137195d20fc498f750975303961a828
ToppCellFrontal_cortex-Macroglia|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 NKAIN1 EFCAB14 PLP1

1.25e-05173775ac70145e093ef0df43811e7c67a865ccdd45a5e3
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Lymphocytic-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAG SHISA2 PLP1 GPR176 BRF2

1.29e-051747756987fe7959afce347282f632abc16d800ccab7c4
ToppCellPosterior_cortex-Macroglia|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 EFCAB14 DEFB109B PLP1

1.32e-051757758bc7a3856d04692989b2a1675ea6d9392261d55a
ToppCell10x5'-GI_large-bowel-Mast|GI_large-bowel / Manually curated celltypes from each tissue

MAG MS4A2 GPAT3 GXYLT1 PLAT

1.44e-05178775d10ed2543c96e1a2373f847e0b82144771e26d07
ToppCell10x5'-GI_large-bowel-Mast-Mast_cells|GI_large-bowel / Manually curated celltypes from each tissue

MAG MS4A2 GPAT3 GXYLT1 PLAT

1.44e-051787758fc5f735afa25ae43c2acb1c710ade6e9e093e3c
ToppCellCOVID-19_Mild-Hematopoietic_SC-HSPC|COVID-19_Mild / Disease group, lineage and cell class

FBN1 MS4A2 LAPTM4B CHRDL1 ARHGEF17

1.48e-0517977519fcf48f5e02e4cb2b328efb4502f337e1282f72
ToppCellPBMC-Mild-Hematopoietic-HSPC-HSPC-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FBN1 MS4A2 LAPTM4B CHRDL1 ARHGEF17

1.48e-051797754bb2debfc9e9f258cd38e797ef160bd440aad6af
ToppCellEntopeduncular-Macroglia|Entopeduncular / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 NKAIN1 EFCAB14 PLP1

1.48e-05179775f61974710a60aa0618fdb30d864fb9bc7c05ef21
ToppCellPBMC-Mild-Hematopoietic-HSPC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FBN1 MS4A2 LAPTM4B CHRDL1 ARHGEF17

1.48e-051797752f690f933bf6b99abeb31766e0b22bdbe36c1ba0
ToppCellPBMC-Mild-Hematopoietic-HSPC-HSPC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FBN1 MS4A2 LAPTM4B CHRDL1 ARHGEF17

1.48e-051797753e2c937369b8190fd5d5a31689d029e6e89fb5e2
ToppCellCOVID-19_Mild-Hematopoietic_SC|COVID-19_Mild / Disease group, lineage and cell class

FBN1 MS4A2 LAPTM4B CHRDL1 ARHGEF17

1.48e-0517977550a073166e34bcfa52a62c4dafb3aef724e0fa8e
ToppCellPBMC-Mild-Hematopoietic-HSPC-HSPC-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

FBN1 MS4A2 LAPTM4B CHRDL1 ARHGEF17

1.56e-05181775e7f7b519c2a01c15f26df11ec9b434c0d1630c7a
ToppCellPBMC-Mild-Hematopoietic-HSPC-HSPC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

FBN1 MS4A2 LAPTM4B CHRDL1 ARHGEF17

1.56e-0518177554a19cf6a3b752e2391feb8b316bebee0e602d17
ToppCellPBMC-Mild-Hematopoietic-HSPC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

FBN1 MS4A2 LAPTM4B CHRDL1 ARHGEF17

1.56e-051817755b84625b1d3737708001b64f6da9360330d39a27
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

PKD2L1 NKAIN1 DEFB109B PLP1

1.58e-0587774f04125fdfa102c0ab30c2fbff874de3bc2edc3af
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

PKD2L1 NKAIN1 DEFB109B PLP1

1.58e-05877748794ac69e8db0c396c0cfc3ee303550c18a6442d
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK36 STAB2 FBN2 RYR2 RYR3

1.69e-051847752cbed6462fea2622871bb7e49b0df3d984239281
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAG CLDN14 NKAIN4 NKAIN3 PLP1

1.69e-05184775226ccac00ac1c3a0ad7283785fd14312320e0ca6
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK36 STAB2 FBN2 RYR2 RYR3

1.69e-05184775ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK36 STAB2 FBN2 RYR2 RYR3

1.69e-051847752b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellCOVID-19_Moderate-HSPC|World / disease group, cell group and cell class

FBN1 MS4A2 LAPTM4B CHRDL1 ARHGEF17

1.69e-05184775ccc93babe1fcdeb66b78e1d8414357877a7c45bd
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam____podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MS4A2 NKAIN4 UPK1B PKD2L1 PLAT

1.73e-05185775872720275789d249c9859de825a923803d458875
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAG CLDN14 NKAIN4 NKAIN3 PLP1

1.87e-05188775ccd2541892112a7a303f766adf9a7afeb754498c
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

STAB2 PLIN5 CHRDL1 USP35 RALGAPA2

1.92e-051897750739baad9a7da511dd3d7249f84299aee88370a1
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP7A NKAIN4 PLAT ARHGEF17 RECK

1.97e-051907751004e89d99c9d46c78b7d3532d8d4aadb81a96fd
ToppCellPND07-28-samps-Mesenchymal-Matrix_fibroblast-FB-3|PND07-28-samps / Age Group, Lineage, Cell class and subclass

FBN1 NKAIN4 UPK1B SHISA2 FGFR3

1.97e-051907751196b8ea2c44c7c80f5ee589dd517e6a413f2077
ToppCellP03-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ATP7A NKAIN4 PLAT ARHGEF17 RECK

1.97e-05190775979b1476fd2692fde977ce56257315fcfc8a01d5
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP7A NKAIN4 PLAT ARHGEF17 RECK

1.97e-0519077510b02c62e72bfea9767e3e751011436925da823e
ToppCellSubstantia_nigra-Macroglia-OLIGODENDROCYTE-O1-Tfr|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

PKD2L1 NKAIN1 DEFB109B PLP1

1.98e-05927740754a79efc4c0659d9a2acfe4185bcae1a3e7206
ToppCellSubstantia_nigra-Macroglia-OLIGODENDROCYTE-O1|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

PKD2L1 NKAIN1 DEFB109B PLP1

1.98e-0592774aee1fd2419dc1fc7039c0ac56f0ba23ed11d668f
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHDC8A LAPTM4B TMPRSS2 TMEM207 DEFB109B

2.02e-051917755a5b5402a077b3189ca156f2bac5f47ad780aebf
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KLHDC8A LAPTM4B TMPRSS2 TMEM207 DEFB109B

2.02e-0519177578bcce497920cc5b3bef083eab50deb1cc82cd2e
ToppCelldroplet-Lung-30m-Mesenchymal|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN1 NKAIN4 UPK1B CHRDL1 ARHGEF17

2.07e-051927755d5bec238b196f0b3e727fd94f078d6ae524cb01
ToppCellPND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOCAD ATP7A NKAIN4 ARHGEF17 RECK

2.07e-05192775158cc5736f154da1cb3186ffbf186eae10483e48
ToppCellPND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FOCAD ATP7A NKAIN4 ARHGEF17 RECK

2.07e-05192775f4ff62ac9c53eafbe917706de9af8b2d4bded4d4
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KLHDC8A LAPTM4B CHRDL1 FGFR3 RYR3

2.17e-0519477568d15917ae222cba0ad9e716d29eebb6c5f00f69
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 UPK1B SHISA2 FGFR3 ARAP1

2.23e-05195775b616ee6f1d878935d293c8e0a8bbc5b4385301f0
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FBN1 FBN2 PLIN5 THSD7B RYR3

2.23e-05195775d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FBN1 FBN2 PLIN5 THSD7B RYR3

2.23e-0519577519853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCellPND07-Mesenchymal-Mesenchymal_structural|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 UPK1B SHISA2 FGFR3 ARAP1

2.23e-051957752f9a274b26fc528a85f50933ec2f4db1dc9da0ca
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Mbp_(Mbp)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

PKD2L1 NKAIN1 DEFB109B PLP1

2.34e-05967749673d03916705c675686bb4282dedd3dc5e98625
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Mbp_(Mbp)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

PKD2L1 NKAIN1 DEFB109B PLP1

2.34e-05967747e2810f5f5a17fcc7ae40edfd3e885740b575e29
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

UPK1B LAPTM4B PLAT FGFR3 RYR1

2.46e-05199775ba284f984909504221900bca5ea12ada5b2ffd9f
ToppCellTracheal-NucSeq-Stromal-Schwann-Schwann_Myelinating|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MAG GPATCH3 CHRDL1 PLAT PLP1

2.46e-051997754e4bdcd2e8b518156d5ebd294804180acaa3566b
ToppCellLPS_anti-TNF-Mesenchymal_myocytic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FBN1 CHRDL1 PLAT ARHGEF17 RYR2

2.52e-0520077567dcbd86fbc79fd585d0793f979e4aac100326c9
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Radial_glial-gliogenic/outer_RGCs_and_astrocytes|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

CHRDL1 PLAT FGFR3 NKAIN3 PLP1

2.52e-05200775792fef1f3e47ce5c131fedfad55075fc254aeead
ToppCellSubstantia_nigra|World / BrainAtlas - Mouse McCarroll V32

MAG TMEM207 IGSF1 PLP1

4.75e-0511577418174b8d57d444fab1e9d2b13d22939c83c958e0
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE-O1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

PKD2L1 NKAIN1 DEFB109B PLP1

5.25e-05118774d0dd5c882cd9e0a5eb0cb08e47877292126bd4ae
ToppCellGlobus_pallidus-Macroglia-OLIGODENDROCYTE-O1-Trf|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

PKD2L1 NKAIN1 DEFB109B PLP1

5.25e-051187744283699cb3ca7a112faa07727dfdc0b0a67fb779
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf|Hippocampus / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 NKAIN1 PLP1

5.42e-051197747367b6e4906d234ca864075443efe420ee407421
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf-Oligodendrocyte.Trf.Ctps_(Ctps)|Hippocampus / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 NKAIN1 PLP1

5.42e-051197740c9aff5442a1b1e51e142d6527d5a48211d94335
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P1-P1_1|Hippocampus / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 NKAIN1 PLP1

5.42e-051197740dd72dbded7ade911612d20e0c6e3f40e85fc890
ToppCell(02)_Cycling_Basal_(regeneration)-(3)_72hpi|(02)_Cycling_Basal_(regeneration) / shred by cell type and Timepoint

FBN1 NKAIN4 PLAT LRIT3

8.36e-0513377432c6a00671af309c4b0b90e93549733729684c61
ToppCellCOVID-19-kidney-Epithelial_(EC)|COVID-19 / Disease (COVID-19 only), tissue and cell type

MAG PLAT THSD7B RYR3

8.36e-05133774a8abb6b54862123961ae6defbf251ee6e9575258
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_1-Tnr-Polydendrocye.Tnr.Ctps_(Ctps)|Striatum / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 POLG2 PLP1

8.60e-05134774bc550d3b44f1e1e1c18971c110e816bcffd79d14
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_1-Tnr|Striatum / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 POLG2 PLP1

8.60e-0513477490a34ae53a602a92f6f998e7cf061d8f4f0da527
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 EFCAB14 PLP1

9.37e-0513777480f1a6cfb48ccfba1c3545fdcd5fcb3157272aca
ToppCellprimary_visual_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Serpinb1a|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MAG CLDN14 NKAIN1 PLP1

9.91e-05139774789edd3c98e7c5c1cc402c780fded9a9dfd1dfb8
ToppCellChildren_(3_yrs)-Immune-mast_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

MS4A2 DSG3 PLAT RYR3

1.20e-04146774f7349d63bb47f1f22ced8ff514edc1c11bc782e7
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

FBN2 THSD7B NKAIN3 RYR2

1.20e-04146774c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCellThalamus-Macroglia-POLYDENDROCYTE-P1|Thalamus / BrainAtlas - Mouse McCarroll V32

MAG CLDN14 ACCSL PLP1

1.23e-04147774a21b63d0d3aec9ffadf3fac833a0a24da58a95bf
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

STAB2 PLAT RALGAPA2 AMIGO1

1.33e-041507744f31867cb85253ff6d22f3b02ef972a42cb41123
Drug2-hydroxycarbazole

RYR1 RYR2 RYR3

3.43e-083753CID000093551
Drugcis-diammineplatinum(II

RYR1 RYR2 RYR3

3.43e-083753CID000159790
Drug2-hydroxyheptanoic acid

RYR1 RYR2 RYR3

3.43e-083753CID002750949
DrugRyanodyl 3-(pyridine-3-carboxylate

RYR1 RYR2 RYR3

3.43e-083753CID005748312
Drug8N3-cADPR

RYR1 RYR2 RYR3

3.43e-083753CID000127713
Drugaminodantrolene

RYR1 RYR2 RYR3

3.43e-083753CID009570289
DrugPCB74

RYR1 RYR2 RYR3

1.37e-074753CID000036218
Drug148504-47-6

RYR1 RYR2 RYR3

1.37e-074753CID006444275
DrugSC 38249

RYR1 RYR2 RYR3

1.37e-074753CID000134834
DrugAC1L1U7A

RYR1 RYR2 RYR3

1.37e-074753CID000035682
Drugdipyrone

MAG MS4A2 RYR1 RYR2 RYR3

2.04e-0740755CID000003110
Drugeuropium

MAG BAZ2A GPAT3 RYR1 RYR2 RYR3

4.26e-0787756CID000023981
Drugetridiazole

ICOS PLAT RYR1 RYR2 RYR3

6.39e-0750755CID000017432
DrugMBED

RYR1 RYR2 RYR3

6.82e-076753CID000129958
Drugchloro-m-cresol

RYR1 RYR2 RYR3

6.82e-076753CID000012008
DrugAC1O528X

RYR1 RYR2 RYR3

6.82e-076753CID006475857
DrugNSC114784

RYR1 RYR2 RYR3

6.82e-076753CID000419425
Drugborate

HDAC3 DSG3 TMPRSS2 RYR1 RYR2 RYR3

8.63e-0798756CID000007628
DrugAzumoleno

RYR1 RYR2 RYR3

1.19e-067753CID000056259
DrugBr2BAPTA

RYR1 RYR2 RYR3

1.19e-067753CID003081001
Drug[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate

RYR1 RYR2 RYR3

1.19e-067753CID009547999
DrugPCB 95

RYR1 RYR2 RYR3

4.05e-0610753CID000038012
Drugcelecoxib; Up 200; 10uM; MCF7; HG-U133A

STAB2 BAZ2A TM4SF5 TMPRSS2 ARHGEF17 S1PR4 BRF2

4.35e-06200757252_UP
DrugPCB 66

RYR1 RYR2 RYR3

5.56e-0611753CID000036185
DrugR 478

RYR1 RYR2 RYR3

5.56e-0611753CID000084223
Drug8-amino-cADPR

RYR1 RYR2 RYR3

5.56e-0611753CID003081323
DrugRyanodine

RYR1 RYR2 RYR3

7.39e-0612753ctd:D012433
Drug5'-adenylyl (beta,gamma-methylene)diphosphonate

RYR1 RYR3

1.07e-052752ctd:C005147
DrugFPL 64176

RYR1 RYR2 RYR3

1.52e-0515753CID000003423
DrugGvapspat amide

RYR1 RYR2 RYR3

1.52e-0515753CID000125015
Drugts M

CHRDL1 RYR1 RYR2 RYR3

1.89e-0548754CID000428025
Drugkazinol B

RYR1 RYR2 RYR3

2.26e-0517753CID000480869
Drugmethylcoumarin

RYR1 RYR2 RYR3

2.70e-0518753CID000007092
DrugAC1L380G

RYR1 RYR2 RYR3

3.20e-0519753CID000084698
DrugAC1MW7VF

RYR1 RYR2 RYR3

3.20e-0519753CID000414699
Drug1,1'-diheptyl-4,4'-bipyridinium

RYR1 RYR3

3.21e-053752CID000080262
Drugflubendiamide

RYR1 RYR3

3.21e-053752CID011193251
Drugindo-1/AM

RYR1 RYR2 RYR3

4.38e-0521753CID000123918
DrugTerconazole [67915-31-5]; Down 200; 7.6uM; MCF7; HT_HG-U133A

HTR1E GPATCH3 BAZ2A KDM4C TMPRSS2 NKAIN1

4.63e-051967562844_DN
Drugmethyl methacrylate

MAG DSG3 POLG2

5.80e-0523753CID000006658
DrugA-30

RYR1 RYR3

6.40e-054752CID003028528
DrugGMA-EDMA

MAG PLAT

6.40e-054752CID003082335
DrugBastadin 10

RYR1 RYR3

6.40e-054752CID009589366
Drugpolyethylenimine

DSG3 PKD2L1 RYR1 RYR2 RYR3

6.54e-05128755CID000009033
DrugT0702

RYR1 RYR2 RYR3

7.49e-0525753CID000005908
Druglanthanum

GPAT3 PKD2L1 RYR1 RYR2 RYR3

8.72e-05136755CID000023926
DrugA 68930

RYR1 RYR2

1.06e-045752ctd:C065380
DrugBicuculline

PLAT RYR1 RYR2

1.18e-0429753ctd:D001640
Drug2,4-xylidinothiazoline

RYR1 RYR2 RYR3

1.31e-0430753CID000099296
DrugLOPAC

RYR1 RYR2 RYR3

1.31e-0430753CID000062696
DrugFura-2AM

MAG RYR1 RYR2 RYR3

1.35e-0479754CID000105091
Druglead compounds

FBN2 TM4SF5 RYR1 RYR2 RYR3

1.38e-04150755CID000073212
DrugM-HN

RYR1 RYR2 RYR3

1.44e-0431753CID000015450
Druglindane

CHRDL1 FGFR3 RYR1 RYR2 RYR3

1.56e-04154755CID000000727
DrugM3/M4

RYR1 RYR2 RYR3

1.59e-0432753CID000486507
Drugrosavin

FBN1 FBN2 DSG3

1.59e-0432753ctd:C529148
DrugNSC692750

RYR1 RYR3

1.59e-046752CID000078910
DrugCNS 1145

RYR1 RYR2 RYR3

1.74e-0433753CID000190902
DrugIHC-64

RYR1 RYR2 RYR3

1.74e-0433753CID000162753
Druglysosphingomyelin

GPR176 RYR1 RYR2 RYR3 S1PR4

1.87e-04160755CID000005263
Drugmag-indo-1

RYR1 RYR3

2.22e-047752CID000131881
DrugCHEBI:564108

RYR1 RYR3

2.22e-047752CID006400637
Drugfodipir

DSG3 PLAT POLG2

2.27e-0436753CID000060683
Drug1,2-dichlorohexafluorocyclobutane

RYR1 RYR2 RYR3

2.46e-0437753CID000009643
Drugmag-fura-2

RYR1 RYR2 RYR3

2.46e-0437753CID000123839
Drug4-chloro-m-cresol

RYR1 RYR2 RYR3

2.46e-0437753CID000001732
Drugruthenium

GPAT3 RYR1 RYR2 RYR3

2.65e-0494754CID000023950
DrugAC1L98DX

RYR1 RYR2 RYR3

2.67e-0438753CID000439957
DrugNAADP

RYR1 RYR2 RYR3

2.88e-0439753CID000123952
DrugNSC-71964

DSG3 CHRDL1

2.96e-048752CID000025306
DrugSM-9

CHRDL1 PLAT

2.96e-048752CID000486038
Drugmethyl-beta-cyclodextrin

DSG3 CHRDL1

2.96e-048752CID000162771
Drugindo-1

MAG RYR1 RYR2 RYR3

3.23e-0499754CID000105060
Drugacrylic acid

MAG DSG3 POLG2

3.34e-0441753CID000006581
DrugDantrolene

RYR1 RYR2 RYR3

3.34e-0441753ctd:D003620
Drugdimethylhydrazine

STK36 CHRDL1 DNMT1

3.34e-0441753CID000005976
DrugRetinoic acid [302-79-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A

MAG STAB2 HTR1E KLHDC8A ARFGEF2

3.66e-041857556243_UP
Druglactosyl lysosphingolipid

RYR1 RYR3

3.80e-049752CID006439268
Drugisophorone

MAG CHRDL1

3.80e-049752CID000006544
DrugFLA 365

RYR1 RYR3

3.80e-049752CID000072776
DrugPyoverdin

DSG3 PLAT RYR1

3.85e-0443753CID005289234
Drugescina

RYR1 RYR2 RYR3

4.13e-0444753CID006433489
DrugEthopropazine hydrochloride [1094-08-2]; Up 200; 11.4uM; PC3; HT_HG-U133A

CLDN14 STAB2 TMPRSS2 ARHGEF17 GPR176

4.13e-041907556697_UP
Drugphosphine oxide

MAG RYR1 RYR2 RYR3

4.34e-04107754CID000166931
Drug4,4'-dithiodipyridine

RYR1 RYR2 RYR3

4.41e-0445753CID000075846
DrugLY 294002; Down 200; 10uM; MCF7; HT_HG-U133A

GPR137 HTR1E FGFR3 ARAP1 KPNB1

4.54e-041947555599_DN
DrugDemeclocycline hydrochloride [64-73-3]; Down 200; 8uM; MCF7; HT_HG-U133A

KDM4C TMPRSS2 ARHGEF17 FAAH ARAP1

4.54e-041947553604_DN
DrugEtifenin [63245-28-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A

ICOS KDM4C ARHGEF17 GPR176 ARAP1

4.54e-041947554117_UP
DrugNSC3260

FBN2 TMPRSS2 RYR1 RYR2 RYR3

4.65e-04195755CID000220461
DrugClomiphene citrate (Z,E) [50-41-9]; Up 200; 6.6uM; MCF7; HT_HG-U133A

ICOS BAZ2A KDM4C UPK1B ARHGEF17

4.65e-041957552624_UP
DrugEthamsylate [2624-44-4]; Down 200; 15.2uM; MCF7; HT_HG-U133A

GPR137 HTR1E ARHGEF17 RYR2 ARAP1

4.65e-041957554399_DN
DrugFlunisolide [3385-03-3]; Down 200; 9.2uM; MCF7; HT_HG-U133A

GPR137 TMPRSS2 NKAIN1 EFCAB14 ARAP1

4.65e-041957553923_DN
DrugFlrf Peptide

FBN2 GPR176

4.74e-0410752CID000129588
DrugAC1N38XE

RYR1 RYR3

4.74e-0410752CID004060965
DrugMaprotiline hydrochloride [10347-81-6]; Down 200; 12.8uM; MCF7; HT_HG-U133A

GPR137 HTR1E NKAIN1 FGFR3 ARAP1

4.76e-041967555022_DN
DrugXylometazoline hydrochloride [1218-35-5]; Up 200; 14.2uM; MCF7; HT_HG-U133A

GPR137 MAG DSG3 CPLANE1 ARHGEF17

4.76e-041967552270_UP
DrugPiretanide [55837-27-9]; Down 200; 11uM; MCF7; HT_HG-U133A

HTR1E GPATCH3 KDM4C GPR176 RYR2

4.76e-041967553567_DN
DrugCapsaicin [404-86-4]; Up 200; 13uM; MCF7; HT_HG-U133A

TM4SF5 TMPRSS2 GPR176 RYR2 ARAP1

4.76e-041967553372_UP
DrugClemizole hydrochloride [1163-36-6]; Up 200; 11uM; PC3; HT_HG-U133A

GPR137 KDM4C KLHDC8A RECK RYR2

4.76e-041967557371_UP
DrugEstropipate [7280-37-7]; Down 200; 9.2uM; HL60; HT_HG-U133A

FBN2 ARFGEF1 ARAP1 S1PR4 BRF2

4.76e-041967552506_DN
Diseasecongenital myopathy 1A (implicated_via_orthology)

RYR1 RYR2 RYR3

1.45e-083733DOID:3529 (implicated_via_orthology)
Diseasemalignant hyperthermia (implicated_via_orthology)

RYR1 RYR2 RYR3

1.45e-083733DOID:8545 (implicated_via_orthology)
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN2

1.81e-053732DOID:65 (implicated_via_orthology)
Diseasescoliosis (is_implicated_in)

FBN1 FBN2

3.61e-054732DOID:0060249 (is_implicated_in)
DiseaseAortic Rupture

FBN1 ATP7A

6.01e-055732C0003496
DiseaseAortic Aneurysm, Ruptured

FBN1 ATP7A

6.01e-055732C0741160
Diseasetissue plasminogen activator measurement

PLAT POLG2

2.15e-049732EFO_0004791
Diseasealopecia areata (is_marker_for)

KDM4C DNMT1

2.68e-0410732DOID:986 (is_marker_for)
Diseaseglycerate measurement

THSD7B RYR3

6.21e-0415732EFO_0021029
Diseasetriacylglycerol 52:3 measurement

PKD2L1 FGFR3

6.21e-0415732EFO_0010415
Diseasepulmonary hypertension (biomarker_via_orthology)

RYR1 RYR2 RYR3

1.04e-0380733DOID:6432 (biomarker_via_orthology)
Diseaseexercise test

LRIT3 RYR2

1.11e-0320732EFO_0004328
Diseasealcohol use disorder (implicated_via_orthology)

KDM4C RYR1 RYR2 RYR3

1.41e-03195734DOID:1574 (implicated_via_orthology)
Diseasehearing impairment

CLDN14 FGFR3 DNMT1

1.87e-0398733C1384666
Diseasechronic myeloid leukemia (is_marker_for)

FGFR3 DNMT1

2.04e-0327732DOID:8552 (is_marker_for)
Diseaseexecutive function measurement

SLC24A4 ARFGEF2 THSD7B ELFN2 RYR1

2.42e-03376735EFO_0009332

Protein segments in the cluster

PeptideGeneStartEntry
VVVLNGCCSVFCALA

ACCSL

236

Q4AC99
ICLCFGTVVCSVLDI

MS4A2

71

Q01362
RAGRAVVSCPAACLC

AMIGO1

26

Q86WK6
ALRGVCSCVEAGKAC

DNMT1

1471

P26358
RCCKALTGIDLSVCT

CCAR1

526

Q8IX12
CRSAAQVCLCLGQLE

BAZ2A

1651

Q9UIF9
CLEGIRCAIRIACIF

ARFGEF1

976

Q9Y6D6
CTCSILHLCVIALDR

HTR1E

106

P28566
CLEGIRCAIRIACIF

ARFGEF2

921

Q9Y6D5
DLASKCQAVICCRVT

ATP8B3

901

O60423
CGFVILAACVVACVG

EFCAB14

76

O75071
ASITVLCIACPCSLG

ATP7A

991

Q04656
VCAVLALVCCASGLF

SLC24A4

26

Q8NFF2
GLGCCELAIALECRQ

RECK

101

O95980
ACIAVCSARILCIGA

ARHGEF17

1541

Q96PE2
SLTLEVCQCDNRGIC

DSG3

581

P32926
GRCSLICLCALQLVS

NKAIN3

6

Q8N8D7
LGAQVCQLERLCCTG

HOGA1

246

Q86XE5
CAAARDTVQCLCVVK

MAG

421

P20916
KNLACSGICASLVCV

GPR176

81

Q14439
CLTENCCSALGRVLL

NLRP11

786

P59045
CALSLAACLCLVARR

GPR137

186

Q96N19
TCCCVISVRGLAQAQ

GPATCH3

101

Q96I76
EVIGRTGLAIICCCV

OR51Q1

141

Q8NH59
RVVVLCVACGFCSLL

GXYLT1

6

Q4G148
GTSLLISCAKCCVRV

KDM4C

711

Q9H3R0
CCLCCHVRTGTILLG

LAPTM4B

106

Q86VI4
AVRACHKVCRCLLSG

POLG2

6

Q9UHN1
CLCIVLSFLEGVGCL

LRIT3

6

Q3SXY7
CAVCDKTCGSVLRLQ

DGKH

261

Q86XP1
VCATCINASRAVKCL

RALGAPA2

1811

Q2PPJ7
CIVLQCGADSLGCDR

HDAC3

251

O15379
GCAAFVVVCILGCIL

ICOS

146

Q9Y6W8
SVCGLTICAAIICTL

FAM189B

176

P81408
TICAAIICTLSAIVC

FAM189B

181

P81408
VTALLCCGLCNGVLI

IGSF1

566

Q8N6C5
ISCLLSGIACACAVI

CLDN14

86

O95500
SIRAIGCFRELCALC

CPLANE1

1266

Q9H799
NLRAFGIVECVLCTC

CHRDL1

276

Q9BU40
LTCCRICVRALSGTI

GPAT3

196

Q53EU6
GIVCTKTLCCATVGR

FBN1

201

P35555
LVCSDCGCVVTEGVL

BRF2

26

Q9HAW0
CLNLFGVCRTDVCNI

DEFB109B

31

Q30KR1
VCLAAVGLVGDLCRA

KPNB1

666

Q14974
RCACSSIVVKNCLLA

KLHDC8A

316

Q8IYD2
CVALLCRPLCGVSTC

KRTAP12-4

41

P60329
VALACCFVAAAVALR

FAAH

16

O00519
CALALCVAVAIVAGA

FGFR3

6

P22607
GIVCTKTLCCATIGR

FBN2

231

P35556
SREVCRAVLSFLCCG

S1PR4

311

O95977
VLCSLCVCNGVAVRS

RYR1

601

P21817
LDVLCSLCVCHGVAV

RYR2

611

Q92736
VVRTACCEGLVALVA

FOCAD

61

Q5VW36
GACLSISCFICIVIS

OR14A2

201

Q96R54
CGTVCSLIHLCLALR

OR5L1

151

Q8NGL2
FCVRVCSGCAVLAVL

RETREG2

186

Q8NC44
VAFIILGSLVAACCC

SHISA2

126

Q6UWI4
GRCTLVAFCCLQLVA

NKAIN1

6

Q4KMZ8
CCLVSEGLCRLLGQE

STK36

721

Q9NRP7
ASINLCVVICKRCAG

ARAP1

561

Q96P48
VGGSLCLTAVIVCCI

CMTM1

111

Q8IZ96
GRCALVVLCAFQLVA

NKAIN4

6

Q8IVV8
CSSKAVVSLRCIACG

TMPRSS2

231

O15393
RGLCCVLLLCGAVFV

PLAT

6

P00750
LCCAVICLLGAGLSN

TRBV18

6

A0A087X0M5
LCSLCLCNGVAVRAN

RYR3

601

Q15413
GGKIVTRICCLCCLN

USP35

571

Q9P2H5
KCVRTVITRECCAGF

STAB2

1326

Q8WWQ8
TAVSQSRICLCAVLC

RFPL2

11

O75678
VSSCCLHICQGIRGL

PKD2L1

66

Q9P0L9
IIGCCGIALTAECIF

UPK1B

21

O75841
ACRLAENCVCGLTTR

PLIN5

56

Q00G26
CARCVGLSLITLCLV

TM4SF5

6

O14894
VLANFLIICCLCGSG

TMC2

431

Q8TDI7
VAALLCGAVVLCLQC

TMEM207

61

Q6UWW9
CGQGVRTRLLSCVCS

THSD7B

1201

Q9C0I4
ALIGQLVVCTLCSCV

RNF145

126

Q96MT1
LCAAALLCVCRPGAV

ELFN2

6

Q5R3F8
CCARCLVGAPFASLV

PLP1

6

P60201