Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF705A NTN1 ZNF721 ZNF80 ZNF600 ZNF716 ZNF676 ZNF225 ZNF782 ZNF700 ZNF556 ZNF442 ZNF25 ZNF709 ZNF850 ZNF416 ZNF726 ZNF730 ZNF682 ZNF722 ZNF705G ZNF790 ZNF563	1.36e-19	1412	33	23	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF705A NTN1 ZNF721 ZNF80 ZNF600 ZNF716 ZNF676 ZNF225 ZNF782 ZNF700 ZNF556 ZNF442 ZNF25 ZNF709 ZNF850 ZNF416 ZNF726 ZNF730 ZNF682 ZNF722 ZNF705G ZNF790 ZNF563	2.83e-19	1459	33	23	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	NTN1 ZNF721 ZNF600 ZNF716 ZNF676 ZNF225 ZNF782 ZNF709 ZNF850 ZNF416 ZNF726 ZNF730 ZNF682 ZNF722 ZNF790	2.72e-10	1244	33	15	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	NTN1 ZNF721 ZNF600 ZNF716 ZNF676 ZNF225 ZNF782 ZNF709 ZNF850 ZNF416 ZNF726 ZNF730 ZNF682 ZNF722 ZNF790	3.67e-10	1271	33	15	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF721 ZNF600 ZNF225 ZNF782 ZNF709 ZNF850 ZNF726 ZNF682	2.72e-06	560	33	8	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF721 ZNF600 ZNF225 ZNF782 ZNF709 ZNF850 ZNF726 ZNF682	2.95e-06	566	33	8	GO:0001216
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZNF721 ZNF782 ZNF709 ZNF726 ZNF682	1.68e-04	320	33	5	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZNF721 ZNF782 ZNF709 ZNF726 ZNF682	1.83e-04	326	33	5	GO:0001217
GeneOntologyMolecularFunction	FAD binding	KDM1B MICAL2	2.40e-03	44	33	2	GO:0071949
GeneOntologyMolecularFunction	damaged DNA binding	ZNF782 ZNF709	8.48e-03	84	33	2	GO:0003684
GeneOntologyMolecularFunction	flavin adenine dinucleotide binding	KDM1B MICAL2	1.05e-02	94	33	2	GO:0050660
Domain	KRAB	ZNF705A ZNF716 ZNF676 ZNF225 ZNF782 ZNF700 ZNF556 ZNF442 ZNF25 ZNF709 ZNF850 ZNF416 ZNF726 ZNF730 ZNF682 ZNF705G ZNF790 ZNF563	2.94e-23	358	32	18	PS50805
Domain	-	ZNF705A ZNF721 ZNF80 ZNF600 ZNF716 ZNF676 ZNF225 ZNF782 ZNF700 ZNF556 ZNF442 ZNF25 ZNF709 ZNF850 ZNF416 ZNF726 ZNF730 ZNF682 ZNF705G ZNF790 ZNF563	3.87e-23	679	32	21	3.30.160.60
Domain	KRAB	ZNF705A ZNF716 ZNF676 ZNF225 ZNF782 ZNF700 ZNF556 ZNF442 ZNF25 ZNF709 ZNF850 ZNF416 ZNF726 ZNF730 ZNF682 ZNF705G ZNF790 ZNF563	5.10e-23	369	32	18	SM00349
Domain	KRAB	ZNF705A ZNF716 ZNF676 ZNF225 ZNF782 ZNF700 ZNF556 ZNF442 ZNF25 ZNF709 ZNF850 ZNF416 ZNF726 ZNF730 ZNF682 ZNF705G ZNF790 ZNF563	5.36e-23	370	32	18	IPR001909
Domain	Znf_C2H2/integrase_DNA-bd	ZNF705A ZNF721 ZNF80 ZNF600 ZNF716 ZNF676 ZNF225 ZNF782 ZNF700 ZNF556 ZNF442 ZNF25 ZNF709 ZNF850 ZNF416 ZNF726 ZNF730 ZNF682 ZNF705G ZNF790 ZNF563	6.12e-23	694	32	21	IPR013087
Domain	zf-C2H2_6	ZNF721 ZNF80 ZNF600 ZNF676 ZNF225 ZNF782 ZNF700 ZNF556 ZNF442 ZNF25 ZNF709 ZNF850 ZNF416 ZNF726 ZNF730 ZNF682 ZNF790	2.00e-22	314	32	17	PF13912
Domain	ZINC_FINGER_C2H2_2	ZNF705A ZNF721 ZNF80 ZNF600 ZNF716 ZNF676 ZNF225 ZNF782 ZNF700 ZNF556 ZNF442 ZNF25 ZNF709 ZNF850 ZNF416 ZNF726 ZNF730 ZNF682 ZNF705G ZNF790 ZNF563	6.12e-22	775	32	21	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF705A ZNF721 ZNF80 ZNF600 ZNF716 ZNF676 ZNF225 ZNF782 ZNF700 ZNF556 ZNF442 ZNF25 ZNF709 ZNF850 ZNF416 ZNF726 ZNF730 ZNF682 ZNF705G ZNF790 ZNF563	6.46e-22	777	32	21	PS00028
Domain	Znf_C2H2-like	ZNF705A ZNF721 ZNF80 ZNF600 ZNF716 ZNF676 ZNF225 ZNF782 ZNF700 ZNF556 ZNF442 ZNF25 ZNF709 ZNF850 ZNF416 ZNF726 ZNF730 ZNF682 ZNF705G ZNF790 ZNF563	1.07e-21	796	32	21	IPR015880
Domain	Znf_C2H2	ZNF705A ZNF721 ZNF80 ZNF600 ZNF716 ZNF676 ZNF225 ZNF782 ZNF700 ZNF556 ZNF442 ZNF25 ZNF709 ZNF850 ZNF416 ZNF726 ZNF730 ZNF682 ZNF705G ZNF790 ZNF563	1.35e-21	805	32	21	IPR007087
Domain	ZnF_C2H2	ZNF705A ZNF721 ZNF80 ZNF600 ZNF716 ZNF676 ZNF225 ZNF782 ZNF700 ZNF556 ZNF442 ZNF25 ZNF709 ZNF850 ZNF416 ZNF726 ZNF730 ZNF682 ZNF705G ZNF790 ZNF563	1.46e-21	808	32	21	SM00355
Domain	KRAB	ZNF705A ZNF716 ZNF225 ZNF782 ZNF700 ZNF556 ZNF442 ZNF25 ZNF709 ZNF850 ZNF416 ZNF726 ZNF730 ZNF682 ZNF705G ZNF790 ZNF563	1.90e-21	358	32	17	PF01352
Domain	zf-C2H2	ZNF705A ZNF721 ZNF80 ZNF600 ZNF716 ZNF676 ZNF225 ZNF782 ZNF700 ZNF556 ZNF442 ZNF25 ZNF709 ZNF850 ZNF416 ZNF726 ZNF730 ZNF682 ZNF790 ZNF563	2.78e-21	693	32	20	PF00096
Domain	-	KDM1B MICAL2	4.13e-03	56	32	2	3.50.50.60
Domain	FAD/NAD-binding_dom	KDM1B MICAL2	4.28e-03	57	32	2	IPR023753
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF705A ZNF721 ZNF600 ZNF716 ZNF676 ZNF225 ZNF782 ZNF700 ZNF556 ZNF442 ZNF25 ZNF709 ZNF416 ZNF726 ZNF730 ZNF682 ZNF705G ZNF790 ZNF563	5.00e-13	1387	29	19	M734
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	ZNF721 ZNF782 ZNF442 ZNF25 ZNF709 ZNF850 ZNF416 ZNF726 ZNF682 ZNF563	1.69e-06	768	29	10	MM14851
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	ZNF721 ZNF782 ZNF442 ZNF25 ZNF709 ZNF850 ZNF416 ZNF726 ZNF682 ZNF563	2.15e-05	1022	29	10	MM15436
Pathway	REACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS	ZNF782 ZNF709 ZNF726	2.02e-04	56	29	3	MM17236
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF721 ZNF25 ZNF850 ZNF726 ZNF682	1.04e-09	49	33	5	9630514
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF721 ZNF716 ZNF726 ZNF682	1.57e-08	29	33	4	14563677
Pubmed	Pax6 is required for the normal development of the forebrain axonal connections.	SEMA5A NTN1	1.83e-05	7	33	2	12397112
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF721 ZNF25 ZNF726 ZNF563	2.58e-05	181	33	4	37372979
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF721 ZNF726	9.10e-05	15	33	2	15885501
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZNF850 ZNF726	1.64e-04	20	33	2	2542606
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZNF850 ZNF726	1.64e-04	20	33	2	7479878
Pubmed	Expansion of the piriform cortex contributes to corticothalamic pathfinding defects in Gli3 conditional mutants.	SEMA5A NTN1	3.99e-04	31	33	2	24014668
Pubmed	Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant.	SEMA5A NTN1	4.25e-04	32	33	2	36737666
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF721 ZNF716 ZNF25 ZNF726 ZNF790	9.25e-04	808	33	5	20412781
Interaction	ZNF716 interactions	ZNF716 ZNF726	6.86e-06	3	31	2	int:ZNF716
Cytoband	19p12	ZNF676 ZNF726 ZNF730 ZNF682	5.41e-07	90	33	4	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF676 ZNF726 ZNF730 ZNF682	1.83e-06	122	33	4	chr19p12
Cytoband	19p13.2	ZNF700 ZNF442 ZNF709 ZNF563	2.20e-05	229	33	4	19p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ZNF700 ZNF556 ZNF442 ZNF709 ZNF563	2.47e-04	797	33	5	chr19p13
Cytoband	19q13.12	ZNF850 ZNF790	1.24e-03	72	33	2	19q13.12
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF600 ZNF225 ZNF850 ZNF416 ZNF790	1.52e-03	1192	33	5	chr19q13
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF705A ZNF721 ZNF80 ZNF600 ZNF716 ZNF676 ZNF225 ZNF782 ZNF700 ZNF556 ZNF442 ZNF25 ZNF709 ZNF850 ZNF416 ZNF726 ZNF730 ZNF682 ZNF705G ZNF790 ZNF563	9.05e-24	718	29	21	28
Disease	interleukin-2 receptor subunit alpha measurement	NTN1 RBM17	1.94e-04	21	29	2	EFO_0010587
Disease	stem Cell Growth Factor beta measurement	ZNF700 ZNF563	2.48e-03	75	29	2	EFO_0008292

Protein segments in the cluster

Peptide	Gene	Start	Entry
DCDSYCKASKGKLKI	NTN1	471	O95631
DYAKRGTAGCKKCKE	LIG3	96	P49916
DEDGGSEKKYRKCEK	KDM1B	41	Q8NB78
SEKKYRKCEKAGCTA	KDM1B	46	Q8NB78
NKVTGYCRKKCKVGE	DEFB128	26	Q7Z7B8
GKDCKKIICDKYKTG	DIPK1A	56	Q5T7M9
KEYKRGKSCTNTKCL	MICAL2	76	O94851
IDGCKKYMRKTCGDV	SMS	226	P52788
CDEATKKACYSKGKS	SEMA5A	96	Q13591
KKKECKDRGFEYDGK	NLN	341	Q9BYT8
KKEKIFTYRCSKEGC	ZFAND2A	91	Q8N6M9
EKTHTGEKRYKCKQC	ZNF700	381	Q9H0M5
LGKKCYECDKSGKAF	ZNF705A	251	Q6ZN79
GEKRYKCEECGKAFS	ZNF676	501	Q8N7Q3
TKEECEKYGKVGKCV	RBM17	326	Q96I25
TGDKLYKCKECGKVF	ZNF721	736	Q8TF20
REKVYKCETCGKTYG	ZNF556	366	Q9HAH1
RGEKSCKYKKCGEAF	ZNF682	476	O95780
TGEKLYKCKECGKAF	ZNF716	431	A6NP11
LGKKCYECDKSGKAF	ZNF705G	251	A8MUZ8
GEKSYECKECGKRFS	ZNF709	136	Q8N972
GEKIYKCKECGKAFR	ZNF730	476	Q6ZMV8
GEKTSKCEDCGKRYK	ZNF225	676	Q9UK10
TTEKSYKCKECGKTF	ZNF726	196	A6NNF4
TLVREGKTYKCKECG	ZNF80	41	P51504
TGKKRYDCKECGKTF	ZNF442	176	Q9H7R0
KKRYECKECGKTFSS	ZNF563	166	Q8TA94
SKGKSYDCDKCGKSF	ZNF25	141	P17030
CTGKRLYESSKCGKA	ZNF416	236	Q9BWM5
TVKKTYECKECGKSF	ZNF790	221	Q6PG37
YKCDECGKAFKLKSG	ZNF782	506	Q6ZMW2
GGEKSYKCKVCDKAF	ZNF600	381	Q6ZNG1
TGEKRYSCKECGKSF	ZNF850	836	A8MQ14
KSYKCEECGKSFKRS	ZNF722	211	A0A1W2PQL4