Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of cytosolic calcium levels

CACNA1A CACNA1B

4.80e-049742GO:0099511
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

CACNA1A CACNA1B

4.80e-049742GO:0099626
GeneOntologyMolecularFunctionpoly(G) binding

HNRNPDL FMR1

5.98e-0410742GO:0034046
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1A CACNA1B CACNG8

6.61e-0446743GO:0005245
GeneOntologyMolecularFunctionUDP-xylosyltransferase activity

XYLT1 GXYLT1

7.29e-0411742GO:0035252
GeneOntologyMolecularFunctionxylosyltransferase activity

XYLT1 GXYLT1

7.29e-0411742GO:0042285
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

MMRN1 EMILIN1

8.73e-0412742GO:0030023
GeneOntologyMolecularFunctionsiRNA binding

FMR1 DHX9

8.73e-0412742GO:0035197
GeneOntologyMolecularFunctionionotropic glutamate receptor binding

CACNG8 SNX27 SHISA7

9.48e-0452743GO:0035255
GeneOntologyMolecularFunctionribonucleoprotein complex binding

DDX17 FMR1 DHX33 SNRNP70 DHX9

1.01e-03206745GO:0043021
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1A CACNA1B

1.20e-0314742GO:0008331
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

MMRN1 EMILIN1

1.20e-0314742GO:0097493
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1A CACNA1B CACNG8 MCU

1.35e-03129744GO:0005262
GeneOntologyMolecularFunctioncalcium-dependent cysteine-type endopeptidase activity

CAPNS1 CAPNS2

1.78e-0317742GO:0004198
GeneOntologyBiologicalProcessskeletal system development

XYLT1 ZBTB7A NPR3 TCF15 MTHFD1L GAS1 SHH GDF11 MED12 SMAD7

5.24e-056157210GO:0001501
GeneOntologyBiologicalProcessregulation of neurotransmitter secretion

CACNA1A CACNA1B FMR1 MCTP1 SYN1

5.80e-05118725GO:0046928
GeneOntologyBiologicalProcessspinal cord patterning

SOX1 SHH GDF11

5.99e-0522723GO:0021511
GeneOntologyBiologicalProcessspinal cord development

SOX1 CACNA1A SHH GDF11 MED12

6.04e-05119725GO:0021510
GeneOntologyCellularComponentcalpain complex

CAPNS1 CAPNS2

7.18e-054732GO:0110158
GeneOntologyCellularComponentcalcium channel complex

CACNA1A CACNA1B CACNG8 MCU

1.24e-0473734GO:0034704
GeneOntologyCellularComponentSchaffer collateral - CA1 synapse

CACNA1B CACNG8 FMR1 SYN1 SNX27

2.10e-04155735GO:0098685
GeneOntologyCellularComponentcaspase complex

CAPNS1 CAPNS2

5.32e-0410732GO:0008303
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1A CACNA1B CACNG8

5.57e-0446733GO:0005891
GeneOntologyCellularComponentdendrite

CACNA1A CACNA1B CACNG8 EPM2A FMR1 MARK4 SHH SYN1 KCNQ3 SHISA7

7.68e-048587310GO:0030425
GeneOntologyCellularComponentdendritic tree

CACNA1A CACNA1B CACNG8 EPM2A FMR1 MARK4 SHH SYN1 KCNQ3 SHISA7

7.82e-048607310GO:0097447
GeneOntologyCellularComponentrecycling endosome

RAB12 RELCH ACAP1 MCTP1 SNX27

1.08e-03222735GO:0055037
GeneOntologyCellularComponentcation channel complex

CACNA1A CACNA1B CACNG8 MCU KCNQ3

1.39e-03235735GO:0034703
GeneOntologyCellularComponentpresynaptic active zone

CACNA1A CACNA1B KCTD8 SYN1

1.51e-03141734GO:0048786
GeneOntologyCellularComponentprotein complex involved in cell-matrix adhesion

MMRN1 EMILIN1

1.58e-0317732GO:0098637
GeneOntologyCellularComponentmonoatomic ion channel complex

CACNA1A CACNA1B CACNG8 MCU KCNQ3 SHISA7

2.06e-03378736GO:0034702
DomainVDCC_a1su_IQ

CACNA1A CACNA1B

3.21e-047742IPR014873
DomainGPHH

CACNA1A CACNA1B

3.21e-047742PF16905
DomainGPHH_dom

CACNA1A CACNA1B

3.21e-047742IPR031649
DomainCa_chan_IQ

CACNA1A CACNA1B

3.21e-047742SM01062
DomainCa_chan_IQ

CACNA1A CACNA1B

3.21e-047742PF08763
DomainPTB

SHC1 TNS2 FAM43A

5.31e-0440743SM00462
DomainBPI1

BPIFB3 BPIFB4

5.48e-049742SM00328
DomainLBP_BPI_CETP

BPIFB3 BPIFB4

5.48e-049742PS00400
DomainBPI2

BPIFB3 BPIFB4

5.48e-049742SM00329
DomainPTB/PI_dom

SHC1 TNS2 FAM43A

5.71e-0441743IPR006020
DomainLBP_BPI_CETP_C

BPIFB3 BPIFB4

6.83e-0410742PF02886
DomainVDCCAlpha1

CACNA1A CACNA1B

6.83e-0410742IPR002077
DomainEMI

MMRN1 EMILIN1

6.83e-0410742PF07546
DomainLipid-bd_serum_glycop_C

BPIFB3 BPIFB4

9.96e-0412742IPR001124
DomainLBP_BPI_CETP

BPIFB3 BPIFB4

1.17e-0313742PF01273
DomainBPI/LBP/Plunc

BPIFB3 BPIFB4

1.17e-0313742IPR032942
DomainBactericidal_perm-incr_a/b_dom

BPIFB3 BPIFB4

1.17e-0313742IPR017943
DomainLipid-bd_serum_glycop_N

BPIFB3 BPIFB4

1.17e-0313742IPR017942
DomainEMI_domain

MMRN1 EMILIN1

1.79e-0316742IPR011489
DomainEMI

MMRN1 EMILIN1

2.03e-0317742PS51041
DomainDUF1605

DHX33 DHX9

2.03e-0317742IPR011709
DomainOB_NTP_bind

DHX33 DHX9

2.03e-0317742PF07717
DomainHA2

DHX33 DHX9

2.27e-0318742SM00847
DomainHA2

DHX33 DHX9

2.27e-0318742PF04408
DomainHelicase-assoc_dom

DHX33 DHX9

2.27e-0318742IPR007502
DomainDEAD/DEAH_box_helicase_dom

DDX17 DHX33 DHX9

3.04e-0373743IPR011545
DomainDEAD

DDX17 DHX33 DHX9

3.04e-0373743PF00270
Domain-

ACAP1 KRT12

6.27e-03307421.20.1270.60
DomainAH/BAR-dom

ACAP1 KRT12

6.27e-0330742IPR027267
DomainC1Q

MMRN1 EMILIN1

7.11e-0332742SM00110
DomainC1q

MMRN1 EMILIN1

7.11e-0332742PF00386
DomainEF-hand_8

CAPNS1 CAPNS2

8.00e-0334742PF13833
DomainC1q_dom

MMRN1 EMILIN1

8.00e-0334742IPR001073
DomainC1Q

MMRN1 EMILIN1

8.00e-0334742PS50871
DomainDNA/RNA_helicase_DEAH_CS

DHX33 DHX9

8.47e-0335742IPR002464
DomainHelicase_C

DDX17 DHX33 DHX9

8.83e-03107743PF00271
DomainHELICc

DDX17 DHX33 DHX9

8.83e-03107743SM00490
DomainHelicase_C

DDX17 DHX33 DHX9

9.05e-03108743IPR001650
DomainHELICASE_CTER

DDX17 DHX33 DHX9

9.28e-03109743PS51194
DomainHELICASE_ATP_BIND_1

DDX17 DHX33 DHX9

9.28e-03109743PS51192
DomainDEXDc

DDX17 DHX33 DHX9

9.28e-03109743SM00487
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1A CACNA1B MCU

6.25e-0523483M47666
PathwayBIOCARTA_INTEGRIN_PATHWAY

CAPNS1 SHC1 CAPNS2

2.06e-0434483M3342
PathwayREACTOME_LIGAND_RECEPTOR_INTERACTIONS

GAS1 SHH

2.36e-047482MM15224
PathwayREACTOME_LIGAND_RECEPTOR_INTERACTIONS

GAS1 SHH

3.14e-048482M27496
PathwayBIOCARTA_P35ALZHEIMERS_PATHWAY

CAPNS1 CAPNS2

3.14e-048482M12718
Pubmed

High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.

HNRNPDL ZBTB7A CACNG8 NPR3 DDX17 AKAP8 HNRNPA0 TNS2 TMEM214 DHX33 HACD2 SNRNP70 ANO8

2.62e-071021751326760575
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

HNRNPDL DDX17 FMR1 AKAP8 OTUD5 GAS1 HNRNPA0 AUTS2 SNX27 SNRNP70 DHX9 SMAD7

6.33e-07922751227609421
Pubmed

Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop.

HNRNPDL DDX17 FMR1 AKAP8 HNRNPA0 LSM4 DHX9

1.55e-0626075736199071
Pubmed

Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.

CACNA1A CACNA1B SYN1

3.45e-061475321228161
Pubmed

AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication.

CACNA1A SHH AUTS2

3.45e-061475333305180
Pubmed

Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels.

CACNA1A CACNA1B

4.59e-06275223426690
Pubmed

Gas1 inhibits cell proliferation and induces apoptosis of human primary gliomas in the absence of Shh.

GAS1 SHH

4.59e-06275219460624
Pubmed

Prdm8 regulates pMN progenitor specification for motor neuron and oligodendrocyte fates by modulating the Shh signaling response.

PRDM8 SHH

4.59e-06275232680935
Pubmed

Complex interplay between FMRP and DHX9 during DNA replication stress.

FMR1 DHX9

4.59e-06275238110032
Pubmed

Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers.

CACNA1A CACNA1B

4.59e-06275223376566
Pubmed

CaV 2.1 α1  subunit motifs that control presynaptic CaV 2.1 subtype abundance are distinct from CaV 2.1 preference.

CACNA1A CACNA1B

4.59e-06275238155373
Pubmed

A sonic hedgehog missense mutation associated with holoprosencephaly causes defective binding to GAS1.

GAS1 SHH

4.59e-06275219478089
Pubmed

Expression analysis of P/Q-type Ca2+ channel alpha 1A subunit mRNA in olfactory mitral cell in N-type Ca2+ channel alpha 1B subunit gene-deficient mice.

CACNA1A CACNA1B

4.59e-06275215050706
Pubmed

RH70, a bidirectional RNA helicase, co-purifies with U1snRNP.

DDX17 SNRNP70

4.59e-06275212193588
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

HNRNPDL DDX17 FMR1 AKAP8 HNRNPA0 KLHDC10 MED12 PURG

7.07e-0646275831138677
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

CACNA1A CACNA1B ZSWIM8 FMR1 TMEM121B SNX27 SHISA7 DHX9

8.65e-0647575831040226
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

HNRNPDL DDX17 TENT4B FMR1 AKAP8 HNRNPA0 LSM4 SNRNP70 PURG DHX9

9.10e-06807751022681889
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

RAB12 CACNA1A CACNA1B CACNG8 TMEM121B SYN1 DHX33

1.03e-0534775717114649
Pubmed

Munc13-3 Is Required for the Developmental Localization of Ca2+ Channels to Active Zones and the Nanopositioning of Cav2.1 Near Release Sensors.

CACNA1A CACNA1B

1.37e-05375229466725
Pubmed

Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides.

BPIFB3 BPIFB4

1.37e-05375212837268
Pubmed

The Primary Ciliary Deficits in Cerebellar Bergmann Glia of the Mouse Model of Fragile X Syndrome.

FMR1 SHH

1.37e-05375235438410
Pubmed

Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting.

CACNA1A CACNA1B

1.37e-05375224394417
Pubmed

The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.

CACNA1A CACNA1B

1.37e-05375238996073
Pubmed

MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling.

SHH MED12

1.37e-05375223091001
Pubmed

Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.

CACNA1A CACNA1B

1.37e-05375224523520
Pubmed

Molecular moieties masking Ca2+-dependent facilitation of voltage-gated Cav2.2 Ca2+ channels.

CACNA1A CACNA1B

1.37e-05375229208674
Pubmed

Early-onset Lafora body disease.

PRDM8 EPM2A

1.37e-05375222961547
Pubmed

Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.

CACNA1A CACNA1B

1.37e-05375226507659
Pubmed

Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.

HNRNPDL DDX17 AKAP8 HNRNPA0 SNRNP70 DHX9

1.51e-0524475629884807
Pubmed

Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.

CACNA1A CACNA1B KCNQ3

1.89e-052475322534482
Pubmed

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.

HNRNPDL DDX17 FMR1 AKAP8 HNRNPA0 SNRNP70

2.06e-0525875637794589
Pubmed

Proteomic analysis of the cullin 4B interactome using proximity-dependent biotinylation in living cells.

HNRNPDL DDX17 HNRNPA0 SNRNP70 DHX9

2.08e-0515375528225217
Pubmed

Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.

CACNA1A CACNA1B

2.75e-05475232616470
Pubmed

Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons.

CACNA1A CACNA1B

2.75e-05475226283199
Pubmed

A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.

CACNA1A CACNA1B

2.75e-05475215728831
Pubmed

Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite.

GAS1 SHH

2.75e-05475211572986
Pubmed

Gas1 is a modifier for holoprosencephaly and genetically interacts with sonic hedgehog.

GAS1 SHH

2.75e-05475217525797
Pubmed

The MAP1B-LC1/UBE2L3 complex catalyzes degradation of cell surface CaV2.2 channels.

CACNA1A CACNA1B

2.75e-05475225483588
Pubmed

Cerebellar granule cell signaling is indispensable for normal motor performance.

CACNA1A CACNA1B

2.75e-05475237141091
Pubmed

Interactions of Rabconnectin-3 with Cav2 calcium channels.

CACNA1A CACNA1B

2.75e-05475231253182
Pubmed

G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels.

CACNA1A CACNA1B

2.75e-05475215953418
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

CACNA1A CACNA1B RELCH CACNG8 DDX17 FMR1 HNRNPA0 KCNQ3 SNRNP70 SHISA7 ANO8

3.19e-051139751136417873
Pubmed

Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.

HNRNPDL DDX17 FMR1 AKAP8 HNRNPA0 SNRNP70 DHX9

3.54e-0542175734650049
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

HNRNPDL DDX17 TENT4B FMR1 AKAP8 DHX33 SNRNP70 MED12 DHX9

3.72e-0575975935915203
Pubmed

Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6.

HNRNPDL HNRNPA0 SNRNP70 DHX9

4.43e-059075423151878
Pubmed

The floor plate is sufficient for development of the sclerotome and spine without the notochord.

TCF15 SHH

4.57e-05575221111815
Pubmed

Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.

CACNA1A CACNA1B

4.57e-0557528825650
Pubmed

Genetic interactions between the hedgehog co-receptors Gas1 and Boc regulate cell proliferation during murine palatogenesis.

GAS1 SHH

4.57e-05575227811357
Pubmed

Vax1 Plays an Indirect Role in the Etiology of Murine Cleft Palate.

GAS1 SHH

4.57e-05575228771384
Pubmed

Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit.

CACNA1A CACNA1B

4.57e-05575216787652
Pubmed

Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.

CACNA1A CACNA1B

4.57e-05575215451373
Pubmed

Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains.

CAPNS1 CAPNS2

4.57e-05575217646163
Pubmed

Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.

CACNA1A CACNA1B

4.57e-05575211296258
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

HNRNPDL DDX17 TENT4B FBLL1 AKAP8 MTHFD1L HNRNPA0 DHX33 SNRNP70 DHX9

5.14e-05989751036424410
Pubmed

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.

DDX17 FMR1 MTHFD1L CAPNS1 SHC1 HNRNPA0 SNRNP70 DHX9

5.44e-0561575831048545
Pubmed

Overlapping, complementary and site-specific expression pattern of genes of the EMILIN/Multimerin family.

MMRN1 EMILIN1

6.84e-05675214996434
Pubmed

An action potential initiation mechanism in distal axons for the control of dopamine release.

CACNA1A CACNA1B

6.84e-05675235324301
Pubmed

GAS1 is required for NOTCH-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium.

GAS1 SHH

6.84e-05675234698766
Pubmed

Restriction of sonic hedgehog signalling during early tooth development.

GAS1 SHH

6.84e-05675215151988
Pubmed

Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.

CACNA1A CACNA1B

6.84e-05675212827191
Pubmed

Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.

CACNA1A CACNA1B

6.84e-0567529238069
Pubmed

Boc modifies the spectrum of holoprosencephaly in the absence of Gas1 function.

GAS1 SHH

6.84e-05675225063195
Pubmed

beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain.

CACNA1A CACNA1B

6.84e-05675210328888
Pubmed

Dynamic protein-protein interaction wiring of the human spliceosome.

DDX17 HNRNPA0 LSM4 SNRNP70 DHX9

6.93e-0519775522365833
Pubmed

Ion channel expression in the developing enteric nervous system.

CACNA1A CACNA1B KCNQ3

7.10e-053775325798587
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

HNRNPDL DDX17 AKAP8 MTHFD1L CAPNS1 HNRNPA0 LSM4 DHX33 SNRNP70 MED12 DHX9

7.73e-051257751137317656
Pubmed

LINKIN, a new transmembrane protein necessary for cell adhesion.

HNRNPDL DDX17 AKAP8 MTHFD1L HNRNPA0 SNRNP70 DHX9

8.07e-0548075725437307
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

DDX17 TENT4B FBLL1 FMR1 AKAP8 HNRNPA0 HACD2 SNRNP70 DHX9

8.63e-0584775935850772
Pubmed

ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.

HNRNPDL ZSWIM8 DDX17 KLHDC10 SNRNP70 DHX9

8.94e-0533675631253590
Pubmed

The von Hippel-Lindau Cullin-RING E3 ubiquitin ligase regulates APOBEC3 cytidine deaminases.

HNRNPDL AKAP8 SNRNP70

8.99e-054075334004371
Pubmed

Rebuilding essential active zone functions within a synapse.

CACNA1A CACNA1B

9.57e-05775235176221
Pubmed

Role of ciliopathy protein TMEM107 in eye development: insights from a mouse model and retinal organoid.

SOX1 SHH

9.57e-05775237863656
Pubmed

PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx.

BPIFB3 BPIFB4

9.57e-05775211971875
Pubmed

Transit-amplifying cells orchestrate stem cell activity and tissue regeneration.

GAS1 SHH

9.57e-05775224813615
Pubmed

Developmental expression and biochemical characterization of Emu family members.

MMRN1 EMILIN1

9.57e-05775212221002
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

HNRNPDL ZBTB7A DDX17 FMR1 AKAP8 HNRNPA0 LSM4 TMEM214 DHX33 SNRNP70 DHX9

1.00e-041294751130804502
Pubmed

The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF.

DDX17 AKAP8 DHX9

1.04e-044275334244791
Pubmed

A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.

HNRNPDL FMR1 HNRNPA0 LSM4 SNRNP70 DHX9

1.07e-0434775616033648
Pubmed

Spatiotemporal expression of sonic hedgehog signalling molecules in the embryonic mesencephalic dopaminergic neurons.

GAS1 SHH

1.27e-04875234767969
Pubmed

Maintenance of somite borders in mice requires the Delta homologue DII1.

TCF15 SHH

1.27e-0487529109488
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

HNRNPDL DDX17 FMR1 AKAP8 HNRNPA0 LSM4 SNRNP70 DHX9

1.51e-0471375829802200
Pubmed

Distinct expression patterns of Hedgehog signaling components in mouse gustatory system during postnatal tongue development and adult homeostasis.

GAS1 SHH

1.64e-04975238848388
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1A CACNA1B

1.64e-04975216382099
Pubmed

Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development.

GAS1 SHH

1.64e-04975226186931
Pubmed

Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning.

SOX1 SHH

1.64e-04975223249739
Pubmed

Sox2 requirement in sonic hedgehog-associated medulloblastoma.

SOX1 SHH

1.64e-04975223596255
Pubmed

Genetic dissection of nodal function in patterning the mouse embryo.

TCF15 SHH

1.64e-04975211311163
Pubmed

Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes.

HNRNPDL MTHFD1L MARK4

1.65e-044975319019082
Pubmed

Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics.

HNRNPDL DDX17 MTHFD1L HNRNPA0 SNRNP70 DHX9

1.85e-0438475631059266
Pubmed

Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.

DDX17 HNRNPA0 SNRNP70 DHX9

1.90e-0413175434551306
Pubmed

Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.

DDX17 FMR1 AKAP8 HNRNPA0 DHX9

1.92e-0424575521182205
Pubmed

SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.

DDX17 FMR1 DHX33 SNRNP70 DHX9

1.92e-0424575535652658
Pubmed

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

HNRNPDL DDX17 CAPNS1 HNRNPA0 LSM4 DHX9

2.01e-0439075617643375
Pubmed

No turning, a mouse mutation causing left-right and axial patterning defects.

TCF15 SHH

2.04e-04107529466889
Pubmed

Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos.

TCF15 SHH

2.04e-041075217325035
Pubmed

Extracellular Fibrinogen-binding Protein (Efb) from Staphylococcus aureus Inhibits the Formation of Platelet-Leukocyte Complexes.

MMRN1 EMILIN1

2.04e-041075226627825
Pubmed

Gas1 Regulates Patterning of the Murine and Human Dentitions through Sonic Hedgehog.

GAS1 SHH

2.04e-041075234796774
Pubmed

Genetic and Molecular Analyses indicate independent effects of TGIFs on Nodal and Gli3 in neural tube patterning.

SHH SMAD7

2.04e-041075227924807
Pubmed

Tbx5 inhibits hedgehog signaling in determination of digit identity.

GAS1 SHH

2.04e-041075231373354
Pubmed

Screening for premutation in the FMR1 gene in male patients suspected of spinocerebellar ataxia.

CACNA1A FMR1

2.04e-041075219235102
InteractionDDX5 interactions

HNRNPDL PHF1 DDX17 FMR1 AKAP8 SHC1 HNRNPA0 SYN1 SNRNP70 MED12 DHX9 SMAD7

9.99e-075687412int:DDX5
CytobandEnsembl 112 genes in cytogenetic band chr19p13

CACNA1A ZBTB7A AKAP8 LSM4 MPND REXO1 ANO8

3.30e-04797757chr19p13
GeneFamilyCalcium voltage-gated channel subunits

CACNA1A CACNA1B CACNG8

4.95e-0526503253
GeneFamilyEMI domain containing

MMRN1 EMILIN1

1.56e-047502540
GeneFamilyBPI fold containing

BPIFB3 BPIFB4

8.77e-0416502456
GeneFamilyDEAH-box helicases

DHX33 DHX9

8.77e-0416502500
GeneFamilyEF-hand domain containing

CACNA1B CAPNS1 CAPNS2 TBC1D8B

3.12e-03219504863
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CACNA1A CACNG8 TCF15 TNS2 SHISA7

6.46e-0615575577fdae85d36efb776db977eb424b32487ef222e4
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPR3 MCTP1 CCM2L TNS2 SMAD7

1.44e-05183755fc9a7ba148c22d0c8a46f6bc56c772929ac496f7
ToppCellPCW_05-06-Endothelial-Endothelial_immature-endo_immature1_(0)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MMRN1 NPR3 TCF15 CCM2L FAM43A

1.87e-051937552661ad9107ed9231e4afea4442a79051139a31df
ToppCellTracheal-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NPR3 MCTP1 CCM2L KIF26A C3orf80

1.96e-05195755517af3e6784f02c382df6f5691945eefaa9ec4ae
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-cortical_neurons_2|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

PRDM8 CACNG8 NPR3 AUTS2 KCNQ3

2.21e-052007550cb0755a101ec655359d051d6a8807408d727c55
ToppCellControl-Epithelial_alveolar-Mes-Like|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KCTD8 MAP3K15 GIGYF1 DHX33

4.43e-05116754df7609503782d8d7e4f31ed2a626916e5474d5bc
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7-Slc17a6.Nptxr-Rorb_(Deep_layer_pyramidal_cells--Layer_5a)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SEC16B PRDM8 KRT12 BPIFB4

5.92e-05125754be820e4db3da737101f34ea9d2848a3ceb53f417
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Gpr139|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TCF15 CCM2L EMILIN1 FAM43A

7.76e-05134754917b8951dd4c870b6b92f2e73e02dac884330c30
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_dendritic-CD141-positive_myeloid_dendritic_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MCTP1 TMEM121B SYN1 PURG

1.03e-04144754a9305d2499189f23b942775285be9fb260ce4214
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb|Cerebellum / BrainAtlas - Mouse McCarroll V32

SCRT2 PRDM8 MTHFD1L MARK4

1.17e-041497546e9ca280a599d96f8956ef26f2a46b9484de5488
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Tnc|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SEC16B PRDM8 KRT12 RRAD

1.33e-041547540066b2b8cfc74603e97f271ef5efc7ec512110dc
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_CCDC184|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCRT2 NPR3 TCF15 KIF26A

1.36e-041557540d7410092b2e8bab7aa9181b9780b9331e483b17
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Lypd1_Gpr88|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SEC16B PRDM8 KRT12 TMEM121B

1.43e-041577545aee90ad7aaa65fdabc23597451da5e48db8f4e6
ToppCelldroplet-Heart-nan-24m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A ZSWIM8 GAS1 DHX33

1.50e-041597547ad3a91d29639b32f6264c91f401c14a35469ac0
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Cbln4_Fezf2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SEC16B PRDM8 KRT12 TMEM121B

1.54e-04160754d8241404d775f9a709abdf17988f36293fcf4c58
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMRN1 CACNG8 CCM2L SMAD7

1.54e-0416075433050dc646762dc7e9dcc4a12c618e1ba1ce5a4d
ToppCellLeuk-UTI-Myeloid-tDC|Leuk-UTI / Disease, Lineage and Cell Type

MMRN1 AVEN SYN1 EMILIN1

1.58e-0416175451b9f60986ed2e8e2297d31c80462c3ab65a2e5e
ToppCellEndothelial-B-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

MMRN1 CCM2L KIF26A FAM43A

1.73e-04165754b6893882472aeb0d18e26f47eaec9d53688afcde
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPR3 MCTP1 CCM2L SMAD7

1.77e-041667547a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCell356C-Endothelial_cells-Endothelial-F_(Lymphatics)-|356C / Donor, Lineage, Cell class and subclass (all cells)

MMRN1 FBLL1 CCM2L KIF26A

1.77e-041667545ba45407a47207ff01e4a3f9f5d91d8247fe9b6f
ToppCell10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor_MEMP|bone_marrow / Manually curated celltypes from each tissue

MMRN1 NPR3 TCF15 C3orf80

1.77e-041667549788486582cc2c5f28b9ea015e235732f9fefb1e
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_SSTR1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCRT2 NPR3 TCF15 CAPNS2

1.77e-041667544547d997afc43e647b1a08e70d5c7fff0e42048f
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_bronchial_vessel-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FMR1 MCTP1 KIF26A FAM43A

1.77e-04166754a697460dfe72e08fbf7d8e734a16b7dd2c6d86f9
ToppCell356C-Endothelial_cells-Endothelial-F_(Lymphatics)|356C / Donor, Lineage, Cell class and subclass (all cells)

MMRN1 FBLL1 CCM2L KIF26A

1.77e-041667546bd5aa205b6e4b88ba9f8cd0999e2191d7d1d16c
ToppCelldroplet-Heart-nan-18m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GAS1 SYN1 DHX33 PURG

1.77e-041667549adceb746e67e955fd8b3e0984f4eed44b64a270
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPR3 MCTP1 CCM2L SMAD7

1.77e-04166754bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCellE16.5-Endothelial-Endothelial_lymphatic|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MMRN1 CCM2L C3orf80 FAM43A

1.81e-04167754b93103a868fba63a8910bffb690a6242b9252833
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MMRN1 CCM2L C3orf80 FAM43A

1.81e-04167754fcd583b1efd0ac883379982ea8e6c54f2c0be268
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MMRN1 CCM2L C3orf80 FAM43A

1.81e-04167754f6bc63138b7239211fa5f27a8dc799b6e022c0f8
ToppCellE16.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MMRN1 CCM2L C3orf80 FAM43A

1.81e-0416775426cd8ee5e826e71eaf58d10a906543a6932fb3f9
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-N_cells_(NTS+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A FBLL1 TMEM121B C3orf80

1.94e-0417075402f0be0aab8ba2d35a83238609352ef3677511c9
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SOX1 NPR3 TCF15 KIF26A

2.03e-041727548b396d1e9173da104d467e42286379fe07cee257
ToppCelldroplet-Mammary_Gland-nan-3m-Endothelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMRN1 TCF15 KIF26A MARK4

2.07e-04173754fbc8ed566ea36c39c258dd6b3823c82f5d6eb17f
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1A SEC16B RELCH SHH

2.17e-0417575496219e58dcb327fd27190be78193e7a0d611e62b
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CACNA1A SEC16B RELCH SHH

2.17e-04175754cb974fbebe8cb58c7d3f7defabb4e056f2fee5fa
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial-N_cells_(NTS+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A FBLL1 SYN1 C3orf80

2.17e-0417575497a58bc6ed2e8e359283d4214172c990c6e3755e
ToppCell3'_v3-lymph-node_spleen-Hematopoietic_progenitors-HSC-MPP|lymph-node_spleen / Manually curated celltypes from each tissue

NPR3 TCF15 C3orf80 EMILIN1

2.21e-0417675432ed5623b8809b9f1aaf7a42dff9807d9376e9c2
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NPR3 CCM2L KIF26A SMAD7

2.26e-041777545ff8dcfb030312126695d53a026d2e104a401b83
ToppCellcontrol-Others-CD34+_GATA2+_cells|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

MMRN1 NPR3 TCF15 C3orf80

2.31e-041787542120bd3e099b0b271bf079db9827a2f3eee2f909
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6|TCGA-Ovary / Sample_Type by Project: Shred V9

XYLT1 PRDM8 C3orf80 EMILIN1

2.31e-04178754142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCellEndothelial-A-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

MMRN1 NPR3 CCM2L FAM43A

2.36e-04179754138fd6ba6bdbd0ad01c574168addf720b67a0fea
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Endothelial-endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMRN1 TCF15 KIF26A CAPNS1

2.41e-041807542405aa5699a8d8cf4c6b3dca07510e774728ac50
ToppCell3'_v3-bone_marrow-Hematopoietic_Erythro-Mega-Erythrocytic-Meg|bone_marrow / Manually curated celltypes from each tissue

MMRN1 NPR3 BPIFB3 EMILIN1

2.41e-0418075444ba37bead1ac39bce4d3eef00961063c50ced0d
ToppCellfacs-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XYLT1 KCNQ3 RRAD SMAD7

2.41e-0418075412537d8a569faa69f474284d2c201475722b8ca1
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

MMRN1 NPR3 CCM2L C3orf80

2.41e-0418075427e8bbee388e64dd79d70b160b76d45b1f398006
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMRN1 TCF15 KIF26A CAPNS1

2.41e-041807549c47852c0a723e2f5cd6898afff4c31a0da06905
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Endothelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMRN1 TCF15 KIF26A CAPNS1

2.41e-04180754499d5fe71e0dc20cffdf85e3b3f14eb4e83e3a3d
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPR3 MCTP1 KIF26A SMAD7

2.46e-041817544d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

XYLT1 NPR3 AUTS2 PURG

2.46e-041817545f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

XYLT1 NPR3 AUTS2 PURG

2.46e-04181754c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCell3'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMRN1 NPR3 MCTP1 TNS2

2.52e-04182754d996ceb77c83591df4cef144ca72862f31d9777f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SOX1 NPR3 TCF15 KIF26A

2.52e-04182754724c33ad2fb525cbcfa5efa3362675eb42a5636d
ToppCellhealthy_donor-Myeloid-Monocytic-SC_&_Eosinophil|healthy_donor / Disease condition, Lineage, Cell class and subclass

MMRN1 CACNG8 NPR3 C3orf80

2.52e-041827546bd6c32c48fecd6d03ac8a09e405b3b99bdc12ae
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NPR3 MCTP1 KIF26A SMAD7

2.57e-041837543427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-hematologic|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NPR3 KIF26A C3orf80 SHISA7

2.57e-041837541db466cf757813322db1cdcc0bf1d91c062fd9de
ToppCell5'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMRN1 MCTP1 SHC1 TNS2

2.57e-04183754a644258ba90acc62d571623e429d72ffc4b69203
ToppCellLPS_only|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

XYLT1 ACAP1 MTHFD1L SLC25A28

2.68e-04185754a72ccb147ca505880e2da8f6a70b9d570464a691
ToppCellEndothelial-A-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

MMRN1 NPR3 CCM2L FAM43A

2.73e-04186754796cbae2a417502aaf0891fc9c382bbfd88967fe
ToppCellPCW_05-06-Endothelial-Endothelial_cycling-endo_proliferating2_(14)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MMRN1 NPR3 TCF15 CCM2L

2.73e-041867542cbf1aaff87cd9fba01f814a119fe86e5af82290
ToppCellSubstantia_nigra-Neuronal|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CACNA1B ZBTB7A FBLL1 SYN1

2.73e-041867543f889083fcffe516388e9b03a5e23af2010ced33
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A KRT12 TMEM121B SHISA7

2.73e-041867547278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCelldroplet-Liver-Npc-21m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF142 SYN1 RRAD

2.76e-04757537f3be37cc378ee115fcb4b0eb9653fc77447aa0a
ToppCelltumor_Lung-Endothelial_cells-Lymphatic_ECs|tumor_Lung / Location, Cell class and cell subclass

MMRN1 CCM2L SHC1 FAM43A

2.79e-0418775487ecdc5f24aced95a37e653429f0fc493ff4aa3e
ToppCellEndothelial-A-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

MMRN1 NPR3 CCM2L FAM43A

2.79e-04187754fd93f3f4b82dae3bf4eef245bfedc2a9e3251b61
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MMRN1 SHC1 EMILIN1 FAM43A

2.79e-0418775465d406122dffe18279f14a1ed35ba091730b97be
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MMRN1 SHC1 EMILIN1 FAM43A

2.79e-041877544c15c0ed41a55271fc793cb76fee97fa64190369
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MMRN1 SHC1 EMILIN1 FAM43A

2.79e-041877545274f2b302bbf7fed30c480af4f35058d2cf61e0
ToppCellFrontal_cortex-Endothelial|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CAPNS1 SHC1 TNS2 EMILIN1

2.85e-04188754a43392dbd10fc7dbfb31be39b8af8a7ea121c894
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MCTP1 CCM2L TNS2 C3orf80

2.85e-04188754a37edd8f9e4a4e336b5acbb0407d3d275975cee8
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MMRN1 SHC1 EMILIN1 FAM43A

2.85e-0418875426915db8863f4115b46a81982e187322e21600fd
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MMRN1 SHC1 EMILIN1 FAM43A

2.85e-041887543f76c0f912f8f023ea425be7f43593b3d7f967e3
ToppCellPCW_13-14-Endothelial-Endothelial_mature-endo_bronchial_(8)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

MMRN1 NPR3 TCF15 CCM2L

2.85e-04188754986aaf31161ec3d1e6c76ee2dd17f44848a21f7e
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MMRN1 SHC1 EMILIN1 FAM43A

2.85e-0418875461ee7b152745164293d8a44ef91ee2393efbdca5
ToppCellCOVID-19_Convalescent-Classical_Monocyte-cMono_3|Classical_Monocyte / Disease condition and Cell class

TMEM121B MARK4 REXO1 SMAD7

2.90e-041897548b6f92ccfffc743c07201bc971b3dc1a6fa14ccc
ToppCell3'-Adult-Distal_Rectal-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMRN1 NPR3 MCTP1 TNS2

2.90e-041897540c612ff5f882f2d8ec744a347780bbbe7cc471bd
ToppCellPBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MCTP1 TMEM121B MARK4 SMAD7

2.90e-04189754a2f4f1dd5452f7efb7427919a0b90875cf2e1dc7
ToppCellCOVID-19_Convalescent-Classical_Monocyte-cMono_3|COVID-19_Convalescent / Disease condition and Cell class

TMEM121B MARK4 REXO1 SMAD7

2.90e-04189754732e8dcffcb634ca2968f9170c9c4b31dd5d4206
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature-endo_bronchial_(8)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MMRN1 NPR3 TCF15 CCM2L

2.90e-041897544bc3826e0515b3cf2e2ef72a7b2cf9c32ade1812
ToppCellStriatum-Endothelial|Striatum / BrainAtlas - Mouse McCarroll V32

CAPNS1 TNS2 RRAD EMILIN1

2.90e-0418975495ee3b6d7fbbfcf91c780dfcd0926acec05f0a2d
ToppCellRA-10._Endothelium_II|World / Chamber and Cluster_Paper

MMRN1 NPR3 MTHFD1L MCU

2.90e-0418975475c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCellPBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MCTP1 TMEM121B MARK4 SMAD7

2.90e-0418975454a45b0cb7dea01caf1cf0a2664c40e5779a0b61
ToppCell3'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MMRN1 NPR3 MCTP1 TNS2

2.90e-04189754bc8949bd4f425ed36e2c05e653c94cb1593c5bee
ToppCellGlobus_pallidus-Neuronal|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SCRT2 CACNA1B ZBTB7A SYN1

2.96e-04190754416de85d8841dac883faa6f5339b2fb461a09e82
ToppCellPCW_05-06-Endothelial-Endothelial_cycling-endo_proliferating1_(10)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MMRN1 NPR3 TCF15 CCM2L

2.96e-041907549a2244c3973aee7270646bf00db7727edb9decc5
ToppCellPCW_07-8.5-Endothelial-Endothelial_cycling-endo_proliferating1_(10)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MMRN1 NPR3 TCF15 CCM2L

3.02e-04191754edfd5eeff69b5de19c5df3d899e42acd7e015913
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MCTP1 CCM2L KIF26A SMAD7

3.02e-04191754b270c3dd5952f56b9bdceabe13e298fe6757563b
ToppCellPCW_07-8.5-Endothelial-Endothelial_immature-endo_immature3_(11)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MMRN1 NPR3 TCF15 CCM2L

3.08e-041927547dbe3117a0f58ff2e838963d49f788a59a4351d7
ToppCellPCW_05-06-Endothelial-Endothelial_immature-endo_immature2_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MMRN1 NPR3 TCF15 CCM2L

3.08e-04192754f68e6cbde87678122da1b5c0061904cfb7d04bf5
ToppCellPCW_07-8.5-Endothelial-Endothelial_cycling-endo_proliferating2_(14)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MMRN1 NPR3 TCF15 CCM2L

3.08e-04192754ac3d87aa301d30515c369bd7fc16f33b82173a85
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MCTP1 MCU KCTD8 MAP3K15

3.08e-04192754bae236c9f1fac77bce28d0a9cf090100d391ff77
ToppCellE15.5-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MMRN1 PRDM8 TCF15 FAM43A

3.14e-041937549f4ffce4e1440b009b0b5947ebf52b12a644704d
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A KRT12 TMEM121B SHISA7

3.14e-04193754be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellLAM-Endothelial-LymEndo|LAM / Condition, Lineage and Cell class

MMRN1 SHC1 EMILIN1 FAM43A

3.14e-0419375468eadc91c2d89edd2412e86dfe134dd7c0ef6ee9
ToppCellRV-10._Endothelium_II|RV / Chamber and Cluster_Paper

MMRN1 NPR3 MTHFD1L MCU

3.14e-0419375401c2df9206f1527c578e808978e58196c35e72f5
ToppCellPCW_10-12-Endothelial-Endothelial_cycling-endo_proliferating1_(10)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MMRN1 NPR3 TCF15 CCM2L

3.14e-04193754643f992dbce639e7d147924d8b8f455fcebf215a
ToppCellPCW_05-06-Endothelial-Endothelial_cycling-endo_proliferating3_(3)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MMRN1 NPR3 TCF15 CCM2L

3.14e-04193754f7e4a390921780587b9bd084e495e646fa1ec74f
ToppCellPCW_07-8.5-Endothelial-Endothelial_cycling-endo_proliferating3_(3)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MMRN1 NPR3 TCF15 CCM2L

3.14e-0419375472128ece598070f8e752a0691e024e26ab364989
ToppCellE15.5-Endothelial-proliferative_endothelial_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MMRN1 PRDM8 TCF15 FAM43A

3.14e-04193754ed6fc4f731624be702563d7d2f0bf366bec1e042
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MCTP1 CCM2L TNS2 C3orf80

3.14e-04193754cc355b2ed6510619cad969ae074126d7c8db784d
ToppCellPCW_07-8.5-Endothelial-Endothelial_immature-endo_immature4_(5)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

MMRN1 NPR3 TCF15 CCM2L

3.14e-0419375472d20ee257149b238016b44d183ce3fc24b8f621
Diseasepreeclampsia, hypertension, pregnancy-induced

PRDM8 NPR3 TNS2

7.62e-0616723EFO_0000668, MONDO_0024664
Diseasefamilial hemiplegic migraine 1 (implicated_via_orthology)

CACNA1A CACNA1B

1.76e-053722DOID:0111181 (implicated_via_orthology)
Diseasemigraine (implicated_via_orthology)

CACNA1A CACNA1B

3.51e-054722DOID:6364 (implicated_via_orthology)
Diseasehereditary ataxia (implicated_via_orthology)

CACNA1A CACNA1B

1.22e-047722DOID:0050951 (implicated_via_orthology)
DiseaseArhinencephaly

GAS1 SHH

1.63e-048722C0078982
Diseasemean arterial pressure

PRDM8 NPR3 MARK4 AUTS2 TNS2 SNRNP70 REXO1

2.16e-04499727EFO_0006340
Diseaseessential hypertension, age at diagnosis

GXYLT1 REXO1 PURG

3.52e-0456723EFO_0004918, MONDO_0001134
DiseaseAlobar Holoprosencephaly

GAS1 SHH

6.04e-0415722C0431363
DiseaseLobar Holoprosencephaly

GAS1 SHH

6.89e-0416722C0431362
DiseaseSemilobar Holoprosencephaly

GAS1 SHH

6.89e-0416722C0751617
DiseaseHoloprosencephaly

GAS1 SHH

7.80e-0417722C0079541
DiseaseFamilial Progressive Myoclonic Epilepsy

PRDM8 EPM2A

7.80e-0417722C0751777
DiseaseAtypical Inclusion-Body Disease

PRDM8 EPM2A

7.80e-0417722C0751776
DiseaseMyoclonic Epilepsies, Progressive

PRDM8 EPM2A

7.80e-0417722C0751778
DiseaseBiotin-Responsive Encephalopathy

PRDM8 EPM2A

7.80e-0417722C0751780
DiseaseMay-White Syndrome

PRDM8 EPM2A

7.80e-0417722C0751782
DiseaseDentatorubral-Pallidoluysian Atrophy

PRDM8 EPM2A

7.80e-0417722C0751781
DiseaseAction Myoclonus-Renal Failure Syndrome

PRDM8 EPM2A

8.76e-0418722C0751779

Protein segments in the cluster

PeptideGeneStartEntry
AGVVVGSGGGRGAGG

CACNA1A

21

O00555
AGAGPVARGGGAGGR

EPM2A

106

B3EWF7
VARGGGAGGRGGGAG

EPM2A

111

B3EWF7
RGLLGSGGLLGGGGL

BPIFB3

61

P59826
EGGRGGSGGGGEGIQ

AKAP8

106

O43823
GQGGLLGGGGLLGDG

BPIFB4

186

P59827
GSGGMARGREPGGVG

ACAP1

391

Q15027
AGGGGGGSLERQRAG

CCM2L

216

Q9NUG4
GGGGGGGREGLLGQR

MTHFD1L

36

Q6UB35
GGGERARGGGAGGAG

CACNA1B

16

Q00975
DEGGGGGSGGGGRRC

ANO8

531

Q9HCE9
GGGGGAGIGGGRQER

NPR3

31

P17342
ALQRRAGGGGGLGAG

RAB12

6

Q6IQ22
QKGGRGAAAGGRGGT

HNRNPDL

321

O14979
GGSGAGGSRGGGQER

RRAD

6

P55042
SGGRAAGGGRADGGG

TENT4B

86

Q8NDF8
GVPGAAGVGGAGGRE

RELCH

151

Q9P260
GAHGGGGGGGAQDKR

KCTD8

191

Q6ZWB6
GVGRSKGGGGGRAGG

MCTP1

31

Q6DN14
RGGGGGGAGGCGALT

MCU

16

Q8NE86
GDRGGCGEEEGRGGG

GIGYF1

256

O75420
GRALGGGSFGGLGMG

KRT12

86

Q99456
GGVGGTGGVGNRAPR

MMRN1

166

Q13201
RRAAGAAGGGGDGGG

KCNQ3

6

O43525
GGGQGGKGGFGARAR

FBLL1

41

A6NHQ2
RGGGDGKDRGGGGQR

FBLL1

66

A6NHQ2
GKDRGGGGQRRGGVA

FBLL1

71

A6NHQ2
RRRGGGAAGAGGGGS

KLHDC10

11

Q6PID8
GGGRGAVRGAGVAGP

GXYLT1

51

Q4G148
SRGGLGAGAAGGGGA

AUTS2

26

Q8WXX7
GVGRGAGGGEAGACR

SLC25A28

36

Q96A46
GGGKGRGLVAGGSRA

KIF26A

1496

Q9ULI4
EEEGGGGSGGRRQGG

MED12

1251

Q93074
LGGGGEARGGTVPGA

GAS1

6

P54826
ERPNAGAGGGRSGGG

MPND

31

Q8N594
AEGGGSGGGGGLRRS

PABIR1

21

Q96E09
GGGGGGGAGAERDRG

CACNG8

346

Q8WXS5
QGGRGRGGGFKGNDD

FMR1

541

Q06787
AAAAVARGGGGGGGG

AVEN

31

Q9NQS1
KGNGGGGGRAGAGDA

HACD2

11

Q6Y1H2
GEALGGLFGGGGQRR

CAPNS2

16

Q96L46
GLFGGGGQRREGGGR

CAPNS2

21

Q96L46
GGGGGGTAMRILGGV

CAPNS1

51

P04632
EGTAGGGGGGRRHIR

GDF11

206

O95390
SLLDSGGGGRGRGGG

C3orf80

156

F5H4A9
LTAGSGGRGGGGGRR

DHX33

36

Q9H6R0
TLENGRGEALGGGGG

FAM43A

316

Q8N2R8
GGQVRDRRAGGGGGG

MARK4

571

Q96L34
DRRAGGGGGGGVQNG

MARK4

576

Q96L34
GAGRGVFGGRGRGGI

LSM4

106

Q9Y4Z0
GRRGTELGGAAGQGG

EMILIN1

381

Q9Y6C2
DRDRGGFGARGGGGL

DDX17

91

Q92841
LVDHRGGGGGGGGRS

DDX17

551

Q92841
GAGVGGGYRGVSRGG

DHX9

1211

Q08211
RRGGGVGVGGGGTGV

OTUD5

31

Q96G74
VGVGGGGTGVGGGDR

OTUD5

36

Q96G74
GGRGRGGKNVGGSGL

PURG

11

Q9UJV8
GGGVRGGVGYLSRGD

PHF1

526

O43189
GGSGEGESGGGPRRA

MAP3K15

46

Q6ZN16
RLGGGLGGTRRGGAD

SNRNP70

191

P08621
SEQVGGGSGGAGRGG

SYN1

96

P17600
DRGQGRGGGGGGALE

REXO1

186

Q8N1G1
RRGGGGGDAGGSGDA

SCRT2

121

Q9NQ03
GGAGGRAGRAGAQAG

SCRT2

136

Q9NQ03
SGGGDRGGGGGRVAL

SHH

401

Q15465
AKARGARGGAGGAGG

TMEM121B

286

Q9BXQ6
ARGGAGGAGGGLGAA

TMEM121B

291

Q9BXQ6
EEARGGGGGLGARGS

NKX1-1

211

Q15270
GGGGLGARGSGCQGA

NKX1-1

216

Q15270
AEGGGGAGLVGGRGR

PRDM8

321

Q9NQV8
EGGRTGGAGGRGGEG

SHISA7

166

A6NL88
GGGGGGGGAKANQDR

SOX1

36

O00570
GRRAGGGGGAGPVVV

TCF15

56

Q12870
EGAGGGGGGGELRGE

SMAD7

26

O15105
GAGERRGGAAVGGGE

XYLT1

41

Q86Y38
RRGYGEEGGGGLTGL

TBC1D8B

31

Q0IIM8
GGRGRGGGRDQNGLS

HNRNPA0

196

Q13151
GGGRDQNGLSKGGGG

HNRNPA0

201

Q13151
GVGAGAGGRGGGRNR

TMEM214

21

Q6NUQ4
AGNGGGGGGGPRVVR

SNX27

31

Q96L92
QASQIGGGGGGGGGR

nan

86

Q8N1X5
GRGGGEGRGSASSGG

SEC16B

976

Q96JE7
GGGGGGGSGGTRMRD

ZSWIM8

56

A7E2V4
AEGCRGGRGGGGKRG

ZNF142

1046

P52746
GGGGARTGGGEGEDR

nan

101

Q6ZS46
GGGGRRTRVEGGQLG

SHC1

116

P29353
GGCGVASGGRGAGRE

TNS2

546

Q63HR2
DGLGRLNVAGAGGGG

ZBTB7A

551

O95365