Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	4 iron, 4 sulfur cluster binding	POLE CIAO3 DNA2 METTL17 MOCS1	1.72e-05	47	137	5	GO:0051539
GeneOntologyMolecularFunction	RNA polymerase II CTD heptapeptide repeat phosphatase activity	CTDSP1 CTDSP2 CTDSPL	8.59e-05	13	137	3	GO:0008420
GeneOntologyMolecularFunction	iron-sulfur cluster binding	POLE CIAO3 DNA2 METTL17 MOCS1	2.00e-04	78	137	5	GO:0051536
GeneOntologyMolecularFunction	metal cluster binding	POLE CIAO3 DNA2 METTL17 MOCS1	2.67e-04	83	137	5	GO:0051540
GeneOntologyMolecularFunction	phosphatidylinositol-3,4,5-trisphosphate binding	OBSCN HIP1R AKT1 DNM1	3.54e-04	49	137	4	GO:0005547
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate binding	OBSCN HIP1R SNX21 DNM1 DNM2	4.99e-04	95	137	5	GO:0005546
GeneOntologyMolecularFunction	RNA polymerase II CTD heptapeptide repeat modifying activity	CTDSP1 CTDSP2 CTDSPL	5.06e-04	23	137	3	GO:0140994
GeneOntologyMolecularFunction	protein serine/threonine kinase binding	AKT1 DNM1 DNM2	5.75e-04	24	137	3	GO:0120283
GeneOntologyBiologicalProcess	proteoglycan biosynthetic process	B4GALT7 MAN1C1 NDST2 CHST13 XYLT1 CHPF2	7.73e-06	70	139	6	GO:0030166
GeneOntologyBiologicalProcess	negative regulation of nodal receptor complex assembly	LEFTY2 LEFTY1	4.51e-05	2	139	2	GO:1900124
GeneOntologyBiologicalProcess	regulation of nodal receptor complex assembly	LEFTY2 LEFTY1	4.51e-05	2	139	2	GO:1900123
GeneOntologyBiologicalProcess	nodal receptor complex assembly	LEFTY2 LEFTY1	4.51e-05	2	139	2	GO:0038099
GeneOntologyBiologicalProcess	synaptic vesicle budding from presynaptic endocytic zone membrane	SLC2A4 DNM1 DNM2	4.75e-05	11	139	3	GO:0016185
GeneOntologyBiologicalProcess	proteoglycan metabolic process	B4GALT7 MAN1C1 NDST2 CHST13 XYLT1 CHPF2	5.02e-05	97	139	6	GO:0006029
GeneOntologyBiologicalProcess	synaptic vesicle budding	SLC2A4 DNM1 DNM2	1.28e-04	15	139	3	GO:0070142
GeneOntologyBiologicalProcess	vesicle scission	DNM1 DNM2	1.35e-04	3	139	2	GO:0099050
GeneOntologyBiologicalProcess	glycosaminoglycan biosynthetic process	B4GALT7 NDST2 CHST13 XYLT1 CHPF2	1.63e-04	76	139	5	GO:0006024
GeneOntologyBiologicalProcess	glycosaminoglycan metabolic process	B4GALT7 STAB2 NDST2 CHST13 XYLT1 CHPF2	1.71e-04	121	139	6	GO:0030203
MousePheno	accessory spleen	LEFTY2 LEFTY1 MEGF8 DNAH11	3.27e-07	9	102	4	MP:0003342
MousePheno	abnormal heart atrium arrangement	LEFTY2 LEFTY1 MEGF8 DNAH11	5.91e-06	17	102	4	MP:0014319
MousePheno	left atrial isomerism	LEFTY2 LEFTY1 DNAH11	2.06e-05	8	102	3	MP:0008461
MousePheno	complete atrioventricular septal defect	LEFTY2 LEFTY1 MEGF8 DNAH11	3.53e-05	26	102	4	MP:0010413
MousePheno	abnormal left renal vein morphology	LEFTY2 LEFTY1	5.27e-05	2	102	2	MP:0011327
MousePheno	abnormal renal vein morphology	LEFTY2 LEFTY1	5.27e-05	2	102	2	MP:0011323
MousePheno	abnormal atrioventricular valve morphology	LEFTY2 LEFTY1 MEGF8 PKD1 DNAH11	1.45e-04	69	102	5	MP:0002745
MousePheno	abnormal kidney venous blood vessel morphology	LEFTY2 LEFTY1	1.57e-04	3	102	2	MP:0011311
MousePheno	abnormal placenta development	SOCS3 KDM3B SLC34A2 LEFTY2 LEFTY1 PKD1 AKT1	1.68e-04	160	102	7	MP:0001712
MousePheno	abnormal hepatic portal vein morphology	LEFTY2 LEFTY1 DNAH11	1.97e-04	16	102	3	MP:0010668
MousePheno	abnormal heart atrium and ventricle connection	LEFTY2 LEFTY1 MEGF8 PKD1 DNAH11	2.16e-04	75	102	5	MP:0010435
Domain	Dullard_phosphatase	CTDSP1 CTDSP2 CTDSPL	3.90e-06	5	138	3	IPR011948
Domain	CPDc	CTDSP1 CTDSP2 CTDSPL	2.15e-05	8	138	3	SM00577
Domain	FCP1	CTDSP1 CTDSP2 CTDSPL	2.15e-05	8	138	3	PS50969
Domain	NIF	CTDSP1 CTDSP2 CTDSPL	3.21e-05	9	138	3	PF03031
Domain	FCP1_dom	CTDSP1 CTDSP2 CTDSPL	3.21e-05	9	138	3	IPR004274
Domain	LRDF	LEFTY2 LEFTY1	5.42e-05	2	138	2	IPR003942
Domain	EGF_LAM_2	STAB2 CELSR1 CELSR2 MEGF8	6.74e-05	30	138	4	PS50027
Domain	EGF_LAM_1	STAB2 CELSR1 CELSR2 MEGF8	6.74e-05	30	138	4	PS01248
Domain	EGF_Lam	STAB2 CELSR1 CELSR2 MEGF8	1.25e-04	35	138	4	SM00180
Domain	Laminin_EGF	STAB2 CELSR1 CELSR2 MEGF8	1.73e-04	38	138	4	IPR002049
Domain	Dynamin_central	DNM1 DNM2	7.97e-04	6	138	2	IPR000375
Domain	GED	DNM1 DNM2	7.97e-04	6	138	2	SM00302
Domain	Dynamin_M	DNM1 DNM2	7.97e-04	6	138	2	PF01031
Domain	GED_dom	DNM1 DNM2	7.97e-04	6	138	2	IPR020850
Domain	GED	DNM1 DNM2	7.97e-04	6	138	2	PS51388
Domain	Dynamin_GTPase_CS	DNM1 DNM2	7.97e-04	6	138	2	IPR019762
Domain	GED	DNM1 DNM2	7.97e-04	6	138	2	PF02212
Domain	GED	DNM1 DNM2	7.97e-04	6	138	2	IPR003130
Domain	PH	AKT3 ARHGAP23 OBSCN NIBAN3 OSBPL7 AKT1 DNM1 DNM2	1.09e-03	278	138	8	SM00233
Domain	tRNA_SAD	TARS3 AARS2	1.11e-03	7	138	2	IPR012947
Domain	G_DYNAMIN_1	DNM1 DNM2	1.11e-03	7	138	2	PS00410
Domain	tRNA_SAD	TARS3 AARS2	1.11e-03	7	138	2	SM00863
Domain	DYNc	DNM1 DNM2	1.11e-03	7	138	2	SM00053
Domain	tRNA_SAD	TARS3 AARS2	1.11e-03	7	138	2	PF07973
Domain	PH_domain	AKT3 ARHGAP23 OBSCN NIBAN3 OSBPL7 AKT1 DNM1 DNM2	1.14e-03	280	138	8	IPR001849
Pathway	WP_GLYCOSAMINOGLYCAN_SYNTHESIS_IN_FIBROBLASTS	B4GALT7 NDST2 CHST13 XYLT1 CHPF2	1.38e-05	41	107	5	M48095
Pathway	KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE	B4GALT7 CHST13 XYLT1 CHPF2	2.07e-05	22	107	4	M19166
Pathway	REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM	B4GALT7 CHST13 XYLT1 CHPF2 GPC2	3.03e-05	48	107	5	MM14696
Pathway	WP_REGULATION_OF_APOPTOSIS_BY_PARATHYROID_HORMONERELATED_PROTEIN	AKT3 BCL2L10 BCL2L2 AKT1	3.51e-05	25	107	4	M39533
Pathway	REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM	B4GALT7 CHST13 XYLT1 CHPF2 GPC2	3.70e-05	50	107	5	M678
Pathway	REACTOME_GLYCOSAMINOGLYCAN_METABOLISM	B4GALT7 STAB2 NDST2 CHST13 XYLT1 CHPF2 GPC2	4.11e-05	123	107	7	MM14623
Pathway	REACTOME_GLYCOSAMINOGLYCAN_METABOLISM	B4GALT7 STAB2 NDST2 CHST13 XYLT1 CHPF2 GPC2	4.79e-05	126	107	7	M695
Pathway	KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY	AKT3 SOCS3 SLC2A4 CPT1C AKT1	1.52e-04	67	107	5	M10462
Pathway	PID_SMAD2_3PATHWAY	CTDSP1 CTDSP2 CTDSPL	2.22e-04	16	107	3	M228
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	POLE SOCS3 OBSCN HIP1R KDM3B RHOT2 ADCY7 FAM83H CTDSP2 FANCA ZNF263 CELSR1 MDN1 CELSR2 MEGF8 XPO6 RBM19 PKD1 EHMT1 AKT1 GPC2 MMP14 IGSF3	9.27e-11	1105	139	23	35748872
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	ARHGAP23 POLE SREBF2 KDM3B ANKRD27 FANCA GTPBP2 RECQL4 CHPF2 TMEM223 DNM1 DNA2 PBXIP1 DNM2 SORL1	5.83e-08	650	139	15	38777146
Pubmed	Gene variants in AKT1, GCKR and SOCS3 are differentially associated with metabolic traits in Mexican Amerindians and Mestizos.	SOCS3 GCKR AKT1	6.25e-08	3	139	3	30176313
Pubmed	Tumor suppressor properties of the small C-terminal domain phosphatases in non-small cell lung cancer.	CTDSP1 CTDSP2 CTDSPL	6.25e-08	3	139	3	31774910
Pubmed	Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system.	LEFTY2 LEFTY1 DNAH11	6.25e-08	3	139	3	17011489
Pubmed	Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways.	CTDSP1 CTDSP2 CTDSPL	6.25e-08	3	139	3	17085434
Pubmed	Optogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action.	AKT3 SLC2A4 AKT1	6.25e-08	3	139	3	27076519
Pubmed	Genetic Analysis Reveals a Hierarchy of Interactions between Polycystin-Encoding Genes and Genes Controlling Cilia Function during Left-Right Determination.	LEFTY2 LEFTY1 PKD1 DNAH11	7.89e-08	11	139	4	27272319
Pubmed	Small C-terminal domain phosphatase enhances snail activity through dephosphorylation.	CTDSP1 CTDSP2 CTDSPL	2.49e-07	4	139	3	19004823
Pubmed	Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos.	LEFTY2 LEFTY1 DNAH11	2.49e-07	4	139	3	9348041
Pubmed	Distinct transcriptional regulatory mechanisms underlie left-right asymmetric expression of lefty-1 and lefty-2.	LEFTY2 LEFTY1 DNAH11	2.49e-07	4	139	3	9990851
Pubmed	Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry.	LEFTY2 LEFTY1 DNAH11	2.49e-07	4	139	3	9708732
Pubmed	Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos.	LEFTY2 LEFTY1 DNAH11	2.49e-07	4	139	3	8610011
Pubmed	Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling.	CTDSP1 CTDSP2 CTDSPL	2.49e-07	4	139	3	16882717
Pubmed	PI3K-Akt signaling pathway upregulates hepatitis C virus RNA translation through the activation of SREBPs.	AKT3 SREBF2 AKT1	6.21e-07	5	139	3	26855332
Pubmed	Determination of left/right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty-2 enhancer.	LEFTY2 LEFTY1 DNAH11	6.21e-07	5	139	3	10385627
Pubmed	Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein.	CTDSP1 CTDSP2 CTDSPL	6.21e-07	5	139	3	32973332
Pubmed	MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein.	CTDSP1 CTDSP2 CTDSPL	1.24e-06	6	139	3	22210897
Pubmed	Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2.	LEFTY2 LEFTY1 DNAH11	1.24e-06	6	139	3	10678167
Pubmed	Nef inhibits glucose uptake in adipocytes and contributes to insulin resistance in human immunodeficiency virus type I infection.	AKT3 SLC2A4 AKT1	1.24e-06	6	139	3	21606541
Pubmed	Wnt3a links left-right determination with segmentation and anteroposterior axis elongation.	LEFTY2 LEFTY1 PKD1 DNAH11	1.39e-06	21	139	4	16291790
Pubmed	Molecular mechanisms of vertebrate left-right development.	LEFTY2 LEFTY1 DNAH11	2.16e-06	7	139	3	9825674
Pubmed	PIERCE1 is critical for specification of left-right asymmetry in mice.	LEFTY2 LEFTY1 DNAH11	3.45e-06	8	139	3	27305836
Pubmed	Two nodal-responsive enhancers control left-right asymmetric expression of Nodal.	LEFTY2 LEFTY1 DNAH11	3.45e-06	8	139	3	15736223
Pubmed	Major histocompatibility complex class-II molecules promote targeting of human immunodeficiency virus type 1 virions in late endosomes by enhancing internalization of nascent particles from the plasma membrane.	HLA-DRB5 DNM1 DNM2	5.16e-06	9	139	3	23170932
Pubmed	A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5.	CTDSP1 CTDSP2 CTDSPL	7.34e-06	10	139	3	12721286
Pubmed	IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway.	POLE CIAO3 MMS19	7.34e-06	10	139	3	23585563
Pubmed	Loss of ciliary transition zone protein TMEM107 leads to heterotaxy in mice.	LEFTY2 LEFTY1 DNAH11	1.34e-05	12	139	3	31887266
Pubmed	Insulin signaling diverges into Akt-dependent and -independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membrane.	SLC2A4 AKT1	1.59e-05	2	139	2	16914513
Pubmed	LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway.	LEFTY2 LEFTY1	1.59e-05	2	139	2	32745796
Pubmed	Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation.	DNM1 DNM2	1.59e-05	2	139	2	21670293
Pubmed	Differential appearance of dynamin in constitutive and regulated exo-endocytosis: a single-cell multiplex RT-PCR study.	DNM1 DNM2	1.59e-05	2	139	2	16028072
Pubmed	A novel function of protein kinase B as an inducer of the mismatch repair gene hPMS2 degradation.	PMS2 AKT1	1.59e-05	2	139	2	23499907
Pubmed	AKT has an anti-apoptotic role in ABCA12-deficient keratinocytes.	ABCA12 AKT1	1.59e-05	2	139	2	21633372
Pubmed	LEFTY, a member of the transforming growth factor-beta superfamily, inhibits uterine stromal cell differentiation: a novel autocrine role.	LEFTY2 LEFTY1	1.59e-05	2	139	2	20056823
Pubmed	Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development.	LEFTY2 LEFTY1	1.59e-05	2	139	2	10053005
Pubmed	Mutation analysis of human LEFTY A and LEFTY B genes in children with Ivemark syndrome.	LEFTY2 LEFTY1	1.59e-05	2	139	2	11100524
Pubmed	Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking.	CELSR1 CELSR2	1.59e-05	2	139	2	23292348
Pubmed	Expression of transketolase-like 1 and activation of Akt in grade IV glioblastomas compared with grades II and III astrocytic gliomas.	TKTL1 AKT1	1.59e-05	2	139	2	18550470
Pubmed	AKT isoforms 1 and 3 regulate basal and epidermal growth factor-stimulated SGHPL-5 trophoblast cell migration in humans.	AKT3 AKT1	1.59e-05	2	139	2	23303682
Pubmed	Akt3 deletion in mice impairs spatial cognition and hippocampal CA1 long long-term potentiation through downregulation of mTOR.	AKT3 AKT1	1.59e-05	2	139	2	30053339
Pubmed	Dynamin regulates L cell secretion in human gut.	DNM1 DNM2	1.59e-05	2	139	2	34274446
Pubmed	Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells.	SLC2A4 AKT1	1.59e-05	2	139	2	18779333
Pubmed	TRIM58 functions as a tumor suppressor in colorectal cancer by promoting RECQL4 ubiquitination to inhibit the AKT signaling pathway.	TRIM58 RECQL4	1.59e-05	2	139	2	37516854
Pubmed	Lefty1 and lefty2 control the balance between self-renewal and pluripotent differentiation of mouse embryonic stem cells.	LEFTY2 LEFTY1	1.59e-05	2	139	2	24147624
Pubmed	PMS2 expression in epithelial ovarian cancer is posttranslationally regulated by Akt and essential for platinum-induced apoptosis.	PMS2 AKT1	1.59e-05	2	139	2	26423401
Pubmed	Akt1 and akt3 exert opposing roles in the regulation of vascular tumor growth.	AKT3 AKT1	1.59e-05	2	139	2	25388284
Pubmed	An intramolecular signaling element that modulates dynamin function in vitro and in vivo.	DNM1 DNM2	1.59e-05	2	139	2	19515832
Pubmed	Lefty antagonises TGF-beta1 induced epithelial-mesenchymal transition in tubular epithelial cells.	LEFTY2 LEFTY1	1.59e-05	2	139	2	20171171
Pubmed	Stra3/lefty, a retinoic acid-inducible novel member of the transforming growth factor-beta superfamily.	LEFTY2 LEFTY1	1.59e-05	2	139	2	9496783
Pubmed	A functional role of LEFTY during progesterone therapy for endometrial carcinoma.	LEFTY2 LEFTY1	1.59e-05	2	139	2	29268772
Pubmed	Expression of transketolase-like 1 (TKTL1) and p-Akt correlates with the progression of cervical neoplasia.	TKTL1 AKT1	1.59e-05	2	139	2	18686341
Pubmed	Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa.	DNM1 DNM2	1.59e-05	2	139	2	22977254
Pubmed	Phosphorylation of Fanconi anemia protein, FANCA, is regulated by Akt kinase.	FANCA AKT1	1.59e-05	2	139	2	11855836
Pubmed	Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways.	LEFTY2 LEFTY1	1.59e-05	2	139	2	33409963
Pubmed	LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca2+ entry.	LEFTY2 LEFTY1	1.59e-05	2	139	2	29230527
Pubmed	Molecular analysis of LEFTY-expressing cells in early human embryoid bodies.	LEFTY2 LEFTY1	1.59e-05	2	139	2	17038673
Pubmed	Rarity of AKT1 and AKT3 E17K mutations in squamous cell carcinoma of lung.	AKT3 AKT1	1.59e-05	2	139	2	20980808
Pubmed	Impaired Spatial Learning is Associated with Disrupted Integrity of the White Matter in Akt3 Knockout Mice.	AKT3 AKT1	1.59e-05	2	139	2	27671373
Pubmed	Passive stretching produces Akt- and MAPK-dependent augmentations of GLUT4 translocation and glucose uptake in skeletal muscles of mice.	SLC2A4 AKT1	1.59e-05	2	139	2	16244881
Pubmed	Dynamin-mediated lipid acquisition is essential for Chlamydia trachomatis development.	DNM1 DNM2	1.59e-05	2	139	2	25116793
Pubmed	Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells.	AKT3 AKT1	1.59e-05	2	139	2	21777670
Pubmed	Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-κB pathway.	LEFTY2 LEFTY1	1.59e-05	2	139	2	29286065
Pubmed	Germline PMS2 and somatic POLE exonuclease mutations cause hypermutability of the leading DNA strand in biallelic mismatch repair deficiency syndrome brain tumours.	PMS2 POLE	1.59e-05	2	139	2	28805995
Pubmed	Dynamin at actin tails.	DNM1 DNM2	1.59e-05	2	139	2	11782545
Pubmed	A multiscale study of the role of dynamin in the regulation of glucose uptake.	SLC2A4 DNM1	1.59e-05	2	139	2	28853753
Pubmed	Isolation, characterization, and function of EBAF/LEFTY B: role in infertility.	LEFTY2 LEFTY1	1.59e-05	2	139	2	21401636
Pubmed	Dynamin 2-dependent endocytosis is essential for mouse oocyte development and fertility.	DNM1 DNM2	1.59e-05	2	139	2	32065700
Pubmed	Lefty is expressed in mouse endometrium in estrous cycle and peri-implantation period.	LEFTY2 LEFTY1	1.59e-05	2	139	2	15640253
Pubmed	The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.	LEFTY2 LEFTY1 DNAH11	1.74e-05	13	139	3	17884984
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	B4GALT7 WARS1 H6PD USP19 DMAP1 FANCA CELSR1 GANAB CELSR2 MEGF8 XPO6 RNFT1 CHPF2 PBXIP1 IGSF3 SORL1	2.61e-05	1201	139	16	35696571
Pubmed	MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.	CIAO3 MMS19 DNA2	2.74e-05	15	139	3	22678361
Pubmed	Rotatin is a novel gene required for axial rotation and left-right specification in mouse embryos.	LEFTY2 LEFTY1 DNAH11	3.37e-05	16	139	3	11900971
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	POLE HIP1R RHOT2 ANKRD27 FAM83H MDN1 FAF2 AARS2 DNA2 DNM2 NSMCE4A	3.43e-05	606	139	11	36538041
Pubmed	Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1.	LEFTY2 LEFTY1 DNAH11	4.08e-05	17	139	3	22357932
Pubmed	Deletion of PKBalpha/Akt1 affects thymic development.	AKT3 AKT1	4.75e-05	3	139	2	17912369
Pubmed	Differential activation of AKT isoforms by growth factors in human myotubes.	AKT3 AKT1	4.75e-05	3	139	2	37879895
Pubmed	Nodal and lefty signaling regulates the growth of pancreatic cells.	LEFTY2 LEFTY1	4.75e-05	3	139	2	18393305
Pubmed	Lefty-1 inhibits renal epithelial-mesenchymal transition by antagonizing the TGF-β/Smad signaling pathway.	LEFTY2 LEFTY1	4.75e-05	3	139	2	32065356
Pubmed	Differential prognostic values of the three AKT isoforms in acute myeloid leukemia.	AKT3 AKT1	4.75e-05	3	139	2	38528080
Pubmed	GSK3α phosphorylates dynamin-2 to promote GLUT4 endocytosis in muscle cells.	SLC2A4 DNM2	4.75e-05	3	139	2	36445308
Pubmed	Role of asymmetric signals in left-right patterning in the mouse.	LEFTY2 LEFTY1	4.75e-05	3	139	2	11471154
Pubmed	Decidual differentiation of stromal cells promotes Proprotein Convertase 5/6 expression and lefty processing.	LEFTY2 LEFTY1	4.75e-05	3	139	2	16141390
Pubmed	Increased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2.	AKT3 AKT1	4.75e-05	3	139	2	15987444
Pubmed	IFT46 plays an essential role in cilia development.	LEFTY2 LEFTY1	4.75e-05	3	139	2	25722189
Pubmed	Distinct transcriptional regulation and phylogenetic divergence of human LEFTY genes.	LEFTY2 LEFTY1	4.75e-05	3	139	2	10886363
Pubmed	Bone marrow mesenchymal stem cell-derived exosomes reduce insulin resistance and obesity in mice via the PI3K/AKT signaling pathway.	SLC2A4 AKT1	4.75e-05	3	139	2	37073893
Pubmed	Role of Akt isoforms in IGF-I-mediated signaling and survival in myoblasts.	AKT3 AKT1	4.75e-05	3	139	2	19703413
Pubmed	MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells.	AKT3 AKT1	4.75e-05	3	139	2	19825827
Pubmed	Kinetic mechanism of AKT/PKB enzyme family.	AKT3 AKT1	4.75e-05	3	139	2	16540465
Pubmed	Association of maternal hypertension and diabetes with variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital heart defects: a case-control study from Pakistani Population.	LEFTY2 LEFTY1	4.75e-05	3	139	2	37097539
Pubmed	Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice.	AKT3 AKT1	4.75e-05	3	139	2	22632897
Pubmed	Molecular alterations in AKT1, AKT2 and AKT3 detected in breast and prostatic cancer by FISH.	AKT3 AKT1	4.75e-05	3	139	2	20102399
Pubmed	Distinct roles of the three Akt isoforms in lactogenic differentiation and involution.	AKT3 AKT1	4.75e-05	3	139	2	18561256
Pubmed	Differential effects of Akt isoforms on somatic cell reprogramming.	AKT3 AKT1	4.75e-05	3	139	2	25037569
Pubmed	All Three AKT Isoforms Can Upregulate Oxygen Metabolism and Lactate Production in Human Hepatocellular Carcinoma Cell Lines.	AKT3 AKT1	4.75e-05	3	139	2	38396845
Pubmed	Dynamin: characteristics, mechanism of action and function.	DNM1 DNM2	4.75e-05	3	139	2	12511974
Pubmed	AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity.	AKT3 AKT1	4.75e-05	3	139	2	29173281
Pubmed	Akt/PKB isoforms expression in the human lumbar herniated disc: correlation with clinical and MRI findings.	AKT3 AKT1	4.75e-05	3	139	2	21590431
Pubmed	Protein kinase Akt activity in human thyroid tumors.	AKT3 AKT1	4.75e-05	3	139	2	29235817
Interaction	ZBBX interactions	POLE CELSR1 CELSR2 DNM1 DNM2 SORL1	4.74e-08	31	133	6	int:ZBBX
Interaction	TOP3B interactions	POLE SOCS3 OBSCN HIP1R KDM3B RHOT2 ADCY7 FAM83H CTDSP2 FANCA ZNF263 CELSR1 MDN1 CELSR2 MEGF8 XPO6 RBM19 PKD1 EHMT1 AKT1 MMS19 GPC2 MMP14 DNA2 NOP2 IGSF3	3.26e-06	1470	133	26	int:TOP3B
GeneFamily	CTD family phosphatases	CTDSP1 CTDSP2 CTDSPL	8.74e-06	8	99	3	1041
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR1 CELSR2	8.87e-05	3	99	2	913
GeneFamily	Adhesion G protein-coupled receptors, subfamily C\|CELSR cadherins	CELSR1 CELSR2	8.87e-05	3	99	2	1189
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	AKT3 ARHGAP23 OSBPL7 AKT1 DNM1 DNM2	9.46e-04	206	99	6	682
GeneFamily	BCL2 family	BCL2L10 BCL2L2	2.59e-03	14	99	2	1057
Disease	Autosomal dominant polycystic kidney disease	GANAB PKD1	6.40e-05	3	137	2	cv:C0085413
Disease	centronuclear myopathy 1 (implicated_via_orthology)	DNM1 DNM2	2.12e-04	5	137	2	DOID:0111223 (implicated_via_orthology)
Disease	microcytic anemia (implicated_via_orthology)	DNM1 DNM2	2.12e-04	5	137	2	DOID:11252 (implicated_via_orthology)
Disease	Charcot-Marie-Tooth disease dominant intermediate B (implicated_via_orthology)	DNM1 DNM2	2.12e-04	5	137	2	DOID:0110197 (implicated_via_orthology)
Disease	insulin-like growth factor-binding protein 1 measurement	GCKR CELSR2	2.12e-04	5	137	2	EFO_0020474
Disease	monocyte count	AKT3 STAB2 ARHGAP23 HLA-DRB5 CCRL2 ZYG11B NUF2 GCKR CHST13 FANCA XPO6 PKD1 EXOC3L1 GSG1L CTDSPL SORL1	4.27e-04	1320	137	16	EFO_0005091
Disease	Polycystic kidney disease, type 2	GANAB PKD1	4.43e-04	7	137	2	C2751306
Disease	group XIIB secretory phospholipase A2-like protein measurement	GCKR CELSR2	4.43e-04	7	137	2	EFO_0801657
Disease	Polycystic Kidney, Type 1 Autosomal Dominant Disease	GANAB PKD1	5.88e-04	8	137	2	C0887850
Disease	Polycystic Kidney, Autosomal Dominant	GANAB PKD1	7.54e-04	9	137	2	C0085413
Disease	Nephroblastoma	NBAS NHS	9.40e-04	10	137	2	Orphanet_654
Disease	lung non-small cell carcinoma (is_marker_for)	AKT3 KDM3B NUF2 AKT1 CTDSPL	1.18e-03	169	137	5	DOID:3908 (is_marker_for)
Disease	chronic musculoskeletal pain	FAF2 AMIGO3	1.37e-03	12	137	2	EFO_0022195
Disease	mismatch repair cancer syndrome (is_implicated_in)	PMS2 POLE	1.37e-03	12	137	2	DOID:0112182 (is_implicated_in)
Disease	collagen disease (implicated_via_orthology)	DNM1 DNM2	1.37e-03	12	137	2	DOID:854 (implicated_via_orthology)
Disease	AL amyloidosis	CHPF2 DNAH11	1.37e-03	12	137	2	MONDO_0019438
Disease	C-reactive protein measurement	AKT3 ZPLD1 OR10J3 SOCS3 NDST2 RTN4RL1 GPRC6A GCKR HSF5 FANCA CELSR2 PKD1 SYT4 DNAH11	1.49e-03	1206	137	14	EFO_0004458
Disease	developmental and epileptic encephalopathy (implicated_via_orthology)	DNM1 DNM2	1.61e-03	13	137	2	DOID:0112202 (implicated_via_orthology)
Disease	apolipoprotein A 1 measurement	AKT3 HLA-DRB5 TECTB HIP1R GCKR CELSR2 XPO6 SYT4 AKT1 GSG1L SORL1	2.06e-03	848	137	11	EFO_0004614
Disease	phospholipids in medium HDL measurement	TECTB GCKR CELSR2	2.15e-03	55	137	3	EFO_0022295
Disease	Hypertriglyceridemia	GCKR CELSR2	2.16e-03	15	137	2	C0020557
Disease	ovarian cancer (is_implicated_in)	PMS2 FANCA AKT1	2.27e-03	56	137	3	DOID:2394 (is_implicated_in)
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	PKD1 AKT1	2.46e-03	16	137	2	DOID:0110861 (implicated_via_orthology)
Disease	total lipids in medium HDL measurement	TECTB GCKR CELSR2	2.51e-03	58	137	3	EFO_0022310
Disease	cholesterol in medium HDL measurement	TECTB GCKR CELSR2	2.63e-03	59	137	3	EFO_0021903
Disease	IGF-1 measurement, IGFBP-3 measurement	GCKR CELSR2	2.78e-03	17	137	2	EFO_0004626, EFO_0004627
Disease	phospholipids in HDL measurement	TECTB GCKR CELSR2	2.89e-03	61	137	3	EFO_0022293
Disease	Malignant neoplasm of endometrium	PMS2 POLE	3.12e-03	18	137	2	C0007103
Disease	Carcinoma in situ of endometrium	PMS2 POLE	3.12e-03	18	137	2	C0346191
Disease	phospholipids:total lipids ratio, high density lipoprotein cholesterol measurement	HLA-DRB5 GCKR CELSR2 GFOD2 AKT1 DNAH11	3.18e-03	307	137	6	EFO_0004612, EFO_0020946
Disease	Global developmental delay	KDM3B NBAS GTPBP2 FBXW11	3.49e-03	133	137	4	C0557874
Disease	non-word reading	COX20 B4GALT7 SORL1	3.78e-03	67	137	3	EFO_0005299
Disease	prostate adenocarcinoma (is_implicated_in)	AKT3 AKT1	3.85e-03	20	137	2	DOID:2526 (is_implicated_in)
Disease	Adenocarcinoma of prostate	FANCA AKT1	3.85e-03	20	137	2	C0007112
Disease	total cholesterol measurement, hematocrit, stroke, ventricular rate measurement, body mass index, atrial fibrillation, high density lipoprotein cholesterol measurement, coronary artery disease, diastolic blood pressure, triglyceride measurement, systolic blood pressure, heart failure, diabetes mellitus, glucose measurement, mortality, cancer	ABCA12 GCKR CELSR2	4.10e-03	69	137	3	EFO_0000275, EFO_0000400, EFO_0000712, EFO_0001645, EFO_0003144, EFO_0004340, EFO_0004348, EFO_0004352, EFO_0004468, EFO_0004530, EFO_0004574, EFO_0004612, EFO_0006335, EFO_0006336, EFO_0007928, MONDO_0004992
Disease	kidney disease (biomarker_via_orthology)	SREBF2 XYLT1	4.24e-03	21	137	2	DOID:557 (biomarker_via_orthology)
Disease	activities of daily living score measurement	RTN4RL1 FZD10	4.24e-03	21	137	2	EFO_0008451
Disease	Malignant neoplasm of breast	WARS1 OBSCN SREBF2 H6PD MCOLN1 EHMT1 NHS EXOC3L1 AKT1 GPC2 MMP14 SORL1	4.39e-03	1074	137	12	C0006142
Disease	Endometrial Carcinoma	PMS2 POLE SOCS3	4.62e-03	72	137	3	C0476089

Protein segments in the cluster

Peptide	Gene	Start	Entry
VLHFLVLSFDRFSRD	SYT11	241	Q9BT88
LGFFRSSYVLHGERR	TRHDE	246	Q9UKU6
NGGELFFHLSRERVF	AKT1	231	P31749
FFHLSRERVFSEDRA	AKT1	236	P31749
RSFSDALIRFSRDHF	EXOC3L1	461	Q86VI1
VFLHKGNFFSARRRV	CCRL2	131	O00421
GFAFISFHRREDAAR	EIF3G	281	O75821
EFHSRLRFNRRGLVA	CWC27	86	Q6UX04
SAAARLRQIHRSFFS	BCL2L10	51	Q9HD36
RLFFRKFNSSHVRET	ABCA12	2216	Q86UK0
VLLFHATTFRRGFQV	GTPBP2	511	Q9BX10
TGDDRFLFRNFHTGI	GSG1L	91	Q6UXU4
RLQRHFTVFAFNFPS	DNAH11	2636	Q96DT5
RFRRTFSDLAAQLHV	BCL2L2	56	Q92843
SFVTFRGLRQRFHFT	CELSR1	1451	Q9NYQ6
RGLRQRFHFTISLTF	CELSR1	1456	Q9NYQ6
SFITFRGLRQRFHFT	CELSR2	1376	Q9HCU4
RGLRQRFHFTLALSF	CELSR2	1381	Q9HCU4
DGINRHSFNSFRLRV	ADCY7	976	P51828
VPASRVRFFQHSRVF	AMIGO3	256	Q86WK7
EGLRRRFLQAFFISH	HSD11B2	356	P80365
GELFFHLSRERVFSE	AKT3	231	Q9Y243
LVLAVGLAVFFFRRH	MMP14	551	P50281
AFHDLRRLTTLFLFN	RTN4RL1	216	Q86UN2
FQAHSREIRELFSTF	RBM19	841	Q9Y4C8
IFAAIFRIRSAEGRH	OR5M10	221	Q6IEU7
SQRLFIDRDGSTFRH	KCTD19	51	Q17RG1
CFRSGFHRDSRVFLV	NIBAN3	656	Q86XR2
VTFREENTIAFRHLF	MCOLN1	91	Q9GZU1
AHDLRGFLNFTLARA	ANO7	801	Q6IWH7
VREFLGRHSERFDRN	ANKRD27	141	Q96NW4
RFDRNIASFHRTFRE	ANKRD27	151	Q96NW4
RLLTSAFIRNRADFF	OTUB2	136	Q96DC9
AFIRNRADFFRHFID	OTUB2	141	Q96DC9
FERFHALIQKRSFRS	MINDY3	146	Q9H8M7
VLSRAFRNRFVELHF	MDN1	1206	Q9NU22
KRFSQSFREVAGRFL	LEFTY1	76	O75610
FFNGTERVRFLHRDI	HLA-DRB5	46	Q30154
TRGRTFDQISAAFHR	SLC2A4	471	P14672
QHALIFNGLFSRLRD	GPC2	136	Q8N158
GHAEVRIMFRQRFFT	MMS19	856	Q96T76
LSGGARINRIFHERF	DNM1	356	Q05193
LAADFSITQFRHIGR	ATP9B	901	O43861
TRFTFELPNHRLRFT	KIAA1109	3016	Q2LD37
HFRFNRAALINVGFL	B4GALT7	136	Q9UBV7
RLRFAVFTGAFHALS	GPR26	166	Q8NDV2
RTSRFLSGIINFIHF	NUF2	116	Q9BZD4
RVANVFTLAFRFGHT	EPX	461	P11678
AFRARLFRESCVFHR	CTDSP1	171	Q9GZU7
HSGRVFRLQFDEFQI	FBXW11	491	Q9UKB1
FLFFLTGRDRLHARG	HERC6	946	Q8IVU3
HDLFSSGLFRFRLDS	MEGF8	356	Q7Z7M0
LSLHFLFVRRNQGAE	NCKAP1L	206	P55160
DDSTVACRFFHFRRL	KDM3B	931	Q7LBC6
RVFRIFKFSRHSQGL	KCND2	296	Q9NZV8
FQRHRLHLAGFSSVR	LY75	1691	O60449
EVHFLSRNTQAFFRV	KCNRG	111	Q8N5I3
TFGSDLFFARHLQRH	POLE	1666	Q07864
LSGGARINRIFHERF	DNM2	356	P50570
RGTHQAFRTFSTALR	NBAS	2351	A2RRP1
RRQFLREHAAPFSAF	MOCS1	46	Q9NZB8
HTFGADFRDVRGFLI	GCKR	351	Q14397
FAFRRGNISSFHSFL	GPRC6A	326	Q5T6X5
FRNVRDIGRFHSSFL	OBSCN	5741	Q5VST9
ARYFSPQARRRFHAA	HHAT	416	Q5VTY9
LFQAGQHFKRRFRGS	CPT1C	761	Q8TCG5
SFILSGFVALFHIRR	FZD10	411	Q9ULW2
DRFHEQFHSLRNFFR	HIP1R	251	O75146
RARLQFERHVSGGLF	IGSF3	751	O75054
RESVDAFTFRHFLQI	KLHL26	181	Q53HC5
FGHFLFTSRIRRSCD	COX20	46	Q5RI15
FDLSRRFDLRFVVIH	DMAP1	161	Q9NPF5
GVFRARLFRESCVFH	CTDSPL	186	O15194
GVFRARLFRESCVFH	CTDSP2	181	O14595
TPSQEHFLFEIFRRR	FANCA	1041	O15360
IRGIRHVTSDDFCFF	GFOD2	211	Q3B7J2
KRFSQSFREVAGRFL	LEFTY2	76	O00292
HFNTFGAERLFRLAS	MBLAC2	231	Q68D91
FRFDFNAFRSRLRHP	MAN1C1	141	Q9NR34
MFEHGSFLRRRRRFT	FOXS1	101	O43638
LAFFFFTHRIRIVQD	SLC44A2	616	Q8IWA5
RQTFLSHGDDFRFQT	FAM83H	431	Q6ZRV2
VRAVRRFGQFHLALS	H6PD	576	O95479
LFFSRRFVLVGDHQQ	DNA2	776	P51530
HQDLRFPRIAFFSTR	EHMT1	1216	Q9H9B1
GFAAVSRAFHEIRAR	METTL17	166	Q9H7H0
GDRAFHRNSLDIFRI	PKD1	3156	P98161
HQARFFRRQTDSSGK	OSBPL7	801	Q9BZF2
GFSSFRRQHKLVFFV	OR10J3	16	Q5JRS4
RFLARFLANTSFQGR	GRIN3B	336	O60391
LALHFTILSFDRFSR	SYT4	236	Q9H2B2
IRFADFGVLHRNELS	TARS3	511	A2RTX5
FLRRGIFFSHRDMNQ	WARS1	131	P23381
VAVGQFHRSFRRDSL	HSF5	186	Q4G112
FDTHKQERRTLNFRG	SORL1	1786	Q92673
RLNRFRVEISFHFEV	TRIM43	281	Q96BQ3
DQSTFLGRARHFFTV	SFXN3	16	Q9BWM7
SQRRREFKDRHFLTF	NHS	271	Q6T4R5
FLFLNTLFIQRGRHE	RHOT2	251	Q8IXI1
ALARLRRTFQAFHSV	RECQL4	1066	O94761
FARGSRFSVAEHQER	TAF1L	1066	Q8IZX4
FIFFAILRIHSAEGR	OR5AL1	236	P0C617
IFAAIFRIRSAEGRH	OR5M1	221	Q8NGP8
TRQEFLLRRFSFSGN	GANAB	856	Q14697
RRFHFSQSLTVIHDF	FAF2	376	Q96CS3
FHVSFIIRDGFARIR	NSMCE4A	306	Q9NXX6
ASFFTAQEARRVRHL	OCSTAMP	431	Q9BR26
NGRDHRATFQFNAFR	TECTB	236	Q96PL2
FGQEGFTRFRERRFH	NOP2	546	P46087
AVRAAFLNFFRDRHG	AARS2	41	Q5JTZ9
FSRHFSLLESQREFV	CIAO3	156	Q9H6Q4
ARARGHDVRFAEFLA	CHST13	216	Q8NET6
DVFLRFSGLHLFRAV	CHPF2	706	Q9P2E5
DRSEFRRAFAGATVH	SLC34A2	206	O95436
GESFSQSFNLIRHRR	ZNF572	446	Q7Z3I7
GHLRTFRQVLRIFFT	RNFT1	341	Q5M7Z0
ERAFFVREALFHLFS	ZYG11B	336	Q9C0D3
QRDVLLFEHDRGRFF	TMEM223	31	A0PJW6
SNTRELRDFFHDRSF	USP19	516	O94966
NFLKSHGRDNARFIR	XYLT1	446	Q86Y38
NGRSQRGRFSFEVFR	ZPLD1	266	Q8TCW7
AFFGEDGIFRHDRLR	PBXIP1	641	Q96AQ6
DGIFRHDRLRFRDFV	PBXIP1	646	Q96AQ6
FQRRTGLLHALSFRD	ARHGAP23	426	Q9P227
RRSRAFEQFLGHLQA	SNX21	211	Q969T3
FQRDLGSLRRLAHSF	SREBF2	1011	Q12772
CGRAFRALSGFFRHQ	ZNF696	326	Q9H7X3
TESRLFLTDFFRNHN	NDST2	841	P52849
GTFLIRDSSDQRHFF	SOCS3	66	O14543
SYFRINRRTIGFQHF	STAB2	2481	Q8WWQ8
NSHFFVATFVRERAA	TBCC	56	Q15814
GKRFSFRSSFRIHER	ZNF709	146	Q8N972
GRSSTDRQFFFINRR	PMS2	281	P54278
FFQRSDLFRHLRIHT	ZNF41	406	P51814
NFRGNRIHFSIFRDL	SLC9C2	201	Q5TAH2
RLNRFRVEISFHFEV	TRIM43B	281	A6NCK2
HRFQLSETNRTLFLF	PSG2	191	P11465
LTTIFHFARFGCDIR	XPO6	271	Q96QU8
FTDFLRLFVSVHLRR	XPO6	371	Q96QU8
FRHLQRDFEFDARGG	ZC3H10	156	Q96K80
GTNSETFRQRFRRFH	ZSCAN29	11	Q8IWY8
QAARAALHFFNFRSG	RARRES1	61	P49788
GRDALDHFVFFFFRR	PXT1	106	Q8NFP0
GSRVRHSFLSNAFFL	SIGLEC11	136	Q96RL6
STFAAFLTRAFDHIR	TKTL1	361	P51854
RFRLEFEKHRGFLAQ	TRIM58	181	Q8NG06
SPEASHLRFRRFRFQ	ZNF263	36	O14978