Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone methyltransferase binding

PAXBP1 WIZ

2.09e-0418242GO:1990226
GeneOntologyBiologicalProcessregulation of canonical Wnt signaling pathway

CSNK1E GLI1 PPM1N WNK2

3.05e-04285244GO:0060828
GeneOntologyBiologicalProcesspositive regulation of canonical Wnt signaling pathway

CSNK1E PPM1N WNK2

3.64e-04121243GO:0090263
GeneOntologyBiologicalProcesscanonical Wnt signaling pathway

CSNK1E GLI1 PPM1N WNK2

6.20e-04344244GO:0060070
GeneOntologyBiologicalProcesspositive regulation of Wnt signaling pathway

CSNK1E PPM1N WNK2

7.93e-04158243GO:0030177
GeneOntologyBiologicalProcessregulation of Wnt signaling pathway

CSNK1E GLI1 PPM1N WNK2

7.98e-04368244GO:0030111
GeneOntologyBiologicalProcesspositive regulation of smoothened signaling pathway

GLI1 KIF7

1.25e-0345242GO:0045880
GeneOntologyBiologicalProcesscerebellar cortex morphogenesis

GLI1 HERC1

1.42e-0348242GO:0021696
DomainTMEM132

TMEM132C TMEM132E

1.58e-055242PF16070
DomainTMEM132D_N

TMEM132C TMEM132E

1.58e-055242PF15705
DomainTMEM132D_C

TMEM132C TMEM132E

1.58e-055242PF15706
DomainTMEM132

TMEM132C TMEM132E

1.58e-055242IPR026307
DomainTMEM132_M

TMEM132C TMEM132E

1.58e-055242IPR031437
DomainTMEM132_C

TMEM132C TMEM132E

1.58e-055242IPR031436
DomainTMEM132_N

TMEM132C TMEM132E

1.58e-055242IPR031435
DomainARM-type_fold

VIRMA NCAPG2 NOC3L

9.04e-03339243IPR016024
PathwayWP_HEDGEHOG_SIGNALING_WP4249

CSNK1E GLI1 KIF7

9.40e-0643143M39706
PathwayKEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY

GLI1 KIF7

8.28e-0514142M47414
PathwayWP_HEDGEHOG_SIGNALING_WP47

GLI1 KIF7

1.09e-0416142M39675
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PTCH1_TO_HEDGEHOG_SIGNALING_PATHWAY

GLI1 KIF7

3.66e-0429142M47372
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_SMO_TO_HEDGEHOG_SIGNALING_PATHWAY

GLI1 KIF7

3.66e-0429142M47377
PathwayPID_HEDGEHOG_GLI_PATHWAY

CSNK1E GLI1

1.01e-0348142M219
PathwayKEGG_HEDGEHOG_SIGNALING_PATHWAY

CSNK1E GLI1

1.37e-0356142M1053
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

NCAPG2 MFAP1 CSNK1E TSPYL1 WIZ

3.90e-0722224537071664
Pubmed

Neogenin, a regulator of adult hippocampal neurogenesis, prevents depressive-like behavior.

NEUROD6 GLI1

2.74e-06424229311593
Pubmed

Identification of novel candidate genes in heterotaxy syndrome patients with congenital heart diseases by whole exome sequencing.

GLI1 KIF7

2.74e-06424232738303
Pubmed

TMEM132: an ancient architecture of cohesin and immunoglobulin domains define a new family of neural adhesion molecules.

TMEM132C TMEM132E

4.56e-06524229088312
Pubmed

Mapping of the mouse corticotropin-releasing hormone receptor 2 gene (Crhr2) to chromosome 6.

NEUROD6 USP39

6.83e-0662429383293
Pubmed

Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.

VIRMA MFAP1 CSNK1E PAXBP1 USP39 NOC3L

8.23e-0673124629298432
Pubmed

Kif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu.

GLI1 KIF7

1.64e-05924221795282
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

MFAP1 PAXBP1 USP39 TSPYL1 WIZ NOC3L

1.90e-0584724635850772
Pubmed

The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling.

GLI1 KIF7

2.05e-051024219549984
Pubmed

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.

GLI1 KIF7

3.54e-051324219592253
Pubmed

Sufu and Kif7 in limb patterning and development.

GLI1 KIF7

4.13e-051424225581370
Pubmed

KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms.

GLI1 KIF7

4.77e-051524226439735
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

VIRMA MFAP1 PAXBP1 USP39 NOC3L

5.06e-0560524528977666
Pubmed

The ventral hippocampus is the embryonic origin for adult neural stem cells in the dentate gyrus.

NEUROD6 GLI1

5.44e-051624223643936
Pubmed

Differential expression of the Tmem132 family genes in the developing mouse nervous system.

TMEM132C TMEM132E

5.44e-051624235690356
Pubmed

Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis.

GLI1 KIF7

5.44e-051624223034632
Pubmed

Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling.

GLI1 KIF7

6.17e-051724224726282
Pubmed

Loss of Wiz Function Affects Methylation Pattern in Palate Development and Leads to Cleft Palate.

GLI1 WIZ

7.75e-051924234150743
Pubmed

Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia.

GLI1 KIF7

9.51e-052124223650387
Pubmed

T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number.

GLI1 KIF7

1.36e-042524227046536
Pubmed

Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.

GLI1 KIF7

1.36e-042524227340223
Pubmed

The small GTPase RSG1 controls a final step in primary cilia initiation.

GLI1 KIF7

1.71e-042824229038301
Pubmed

WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.

DCAF11 HERC1

3.50e-044024229078390
Pubmed

Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production.

MFAP1 PAXBP1 USP39

3.78e-0420624322174317
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

NCAPG2 MFAP1 NOC3L

4.00e-0421024316565220
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

NCAPG2 MFAP1 CSNK1E PAXBP1 KIF7 NOC3L

4.19e-04148724633957083
Pubmed

SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.

MFAP1 USP39 HERC1

6.26e-0424524335652658
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

MFAP1 PAXBP1 USP39

6.72e-0425124331076518
InteractionPRPF3 interactions

VIRMA MFAP1 CSNK1E PAXBP1 USP39 TSPYL1

9.31e-07291246int:PRPF3
InteractionGLI2 interactions

VIRMA GLI1 KIF7 HERC1

5.40e-0699244int:GLI2
InteractionBRD3 interactions

VIRMA MFAP1 PSMG1 USP39 TSPYL1 WIZ

1.95e-05494246int:BRD3
InteractionZNF571 interactions

VIRMA HERC1

2.03e-056242int:ZNF571
InteractionMTMR4 interactions

VIRMA NCAPG2 CSNK1E KIF7

3.42e-05158244int:MTMR4
InteractionSLX4 interactions

VIRMA NCAPG2 MFAP1 CSNK1E TSPYL1 WIZ

4.43e-05572246int:SLX4
InteractionZC3H18 interactions

VIRMA MFAP1 CSNK1E PAXBP1 USP39 TSPYL1 NOC3L

5.21e-05877247int:ZC3H18
InteractionSRPK3 interactions

MFAP1 PAXBP1 USP39 NOC3L

7.02e-05190244int:SRPK3
InteractionCOPRS interactions

VIRMA USP39 WIZ

8.04e-0571243int:COPRS
InteractionPIBF1 interactions

VIRMA MFAP1 BFSP1 KIF7

8.56e-05200244int:PIBF1
InteractionZNF555 interactions

VIRMA HERC1

8.91e-0512242int:ZNF555
InteractionRNU6ATAC interactions

VIRMA USP39

1.23e-0414242int:RNU6ATAC
InteractionBICD2 interactions

VIRMA MFAP1 CSNK1E BFSP1 KIF7

1.26e-04426245int:BICD2
InteractionPCM1 interactions

VIRMA CSNK1E BFSP1 KIF7 TSPYL1

1.37e-04434245int:PCM1
InteractionFBXL17 interactions

VIRMA GLI1 DCAF11

1.37e-0485243int:FBXL17
InteractionCD2BP2 interactions

VIRMA MFAP1 PAXBP1 USP39

1.52e-04232244int:CD2BP2
InteractionDHX40 interactions

VIRMA MFAP1 PAXBP1 HERC1

1.99e-04249244int:DHX40
GeneFamilyWD repeat domain containing

DCAF11 HERC1

1.47e-02262132362

Protein segments in the cluster

PeptideGeneStartEntry
EEGDRDEDSEERELP

CCDC27

376

Q2M243
EEEEIDDEEIERRRG

MFAP1

136

P55081
REEGHPEPEDEEEER

HERC1

1361

Q15751
GLRRSEEEEEEDEDV

DCAF11

26

Q8TEB1
REEEEEEEAGRRAPE

PPM1N

26

Q8N819
AASEEEEEEEEPPRR

KIF7

621

Q2M1P5
DGREDLEREEKREPE

GLI1

216

P08151
SEEEERERDEEQEPP

PAXBP1

16

Q9Y5B6
EEEEEEGRRETPEDR

PSMG1

21

O95456
PEEKREGEERDEESR

BFSP1

556

Q12934
RPGKRIEREEEEEEE

NOC3L

71

Q8WTT2
RVKREREVDEDSEPE

USP39

71

Q53GS9
REVDEDSEPEREVRA

USP39

76

Q53GS9
KRPTRESEDEDEEER

TMEM132C

551

Q8N3T6
RESEDEDEEEEERRQ

TMEM132E

566

Q6IEE7
EAERIEELEPEAEER

RHBDL3

16

P58872
RRRPWSEEEEEEEEE

WIZ

561

O95785
VREPPEDEEEEDGRE

NCAPG2

586

Q86XI2
EEDRLEEEAREEEGP

TSPYL1

206

Q9H0U9
GRTRRDEPEEEEDDE

WNK2

166

Q9Y3S1
RDEEPEEEGEEDLRD

VASH1

41

Q7L8A9
DDRRTVDSIPEEEEE

VIRMA

266

Q69YN4
PEDVDRERREHEREE

CSNK1E

301

P49674
EEEEEDGSREERLPS

SLC8A2

706

Q9UPR5
EEEDREEEDENGLPR

NEUROD6

61

Q96NK8