Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	LRR_8	FLII ISLR2 LRCH2 MFHAS1 LRRC2 PRELP PHLPP1	5.11e-05	171	105	7	PF13855
Domain	Leu-rich_rpt_typical-subtyp	FLII ISLR2 LRCH2 MFHAS1 LRRC2 PRELP PHLPP1	6.36e-05	177	105	7	IPR003591
Domain	LRR_TYP	FLII ISLR2 LRCH2 MFHAS1 LRRC2 PRELP PHLPP1	6.36e-05	177	105	7	SM00369
Domain	Glyco_hydro_20	HEXB HEXD	9.36e-05	3	105	2	PF00728
Domain	Glyco_hydro_20_cat	HEXB HEXD	9.36e-05	3	105	2	IPR015883
Domain	TF_fork_head_CS_2	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.28e-04	46	105	4	IPR030456
Domain	TF_fork_head_CS_1	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.40e-04	47	105	4	IPR018122
Domain	LRR	FLII ISLR2 LRCH2 MFHAS1 LRRC2 PRELP PHLPP1	1.41e-04	201	105	7	PS51450
Domain	FH	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.64e-04	49	105	4	SM00339
Domain	FORK_HEAD_1	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.64e-04	49	105	4	PS00657
Domain	FORK_HEAD_2	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.64e-04	49	105	4	PS00658
Domain	Fork_head_dom	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.64e-04	49	105	4	IPR001766
Domain	FORK_HEAD_3	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.64e-04	49	105	4	PS50039
Domain	Forkhead	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.64e-04	49	105	4	PF00250
Domain	Multidrug-R_assoc	ABCC3 ABCC2	1.86e-04	4	105	2	IPR005292
Domain	LRR_1	FLII ISLR2 LRCH2 MFHAS1 LRRC2 PRELP PHLPP1	2.38e-04	219	105	7	PF00560
Domain	PROTEIN_KINASE_ATP	MOK MAP4K3 CLK4 ADCK1 ROR2 PAK4 STYK1 IRAK2 PTK2B STK10	2.62e-04	459	105	10	PS00107
Domain	Biotin_BS	ACACB PCCA	3.10e-04	5	105	2	IPR001882
Domain	Biotin_carb_C	ACACB PCCA	3.10e-04	5	105	2	SM00878
Domain	Biotin_carb_C	ACACB PCCA	3.10e-04	5	105	2	PF02785
Domain	Biotin_carboxylation_dom	ACACB PCCA	3.10e-04	5	105	2	IPR011764
Domain	CPSASE_1	ACACB PCCA	3.10e-04	5	105	2	PS00866
Domain	Biotin_COase_C	ACACB PCCA	3.10e-04	5	105	2	IPR005482
Domain	BIOTIN	ACACB PCCA	3.10e-04	5	105	2	PS00188
Domain	BC	ACACB PCCA	3.10e-04	5	105	2	PS50979
Domain	Prot_kinase_dom	MOK MAP4K3 CLK4 ADCK1 ROR2 PAK4 STYK1 IRAK2 PTK2B STK10	4.32e-04	489	105	10	IPR000719
Domain	PROTEIN_KINASE_DOM	MOK MAP4K3 CLK4 ADCK1 ROR2 PAK4 STYK1 IRAK2 PTK2B STK10	4.60e-04	493	105	10	PS50011
Domain	CPSASE_2	ACACB PCCA	4.63e-04	6	105	2	PS00867
Domain	Rudment_hybrid_motif	ACACB PCCA	4.63e-04	6	105	2	IPR011054
Domain	CPSase_L_D2	ACACB PCCA	6.45e-04	7	105	2	PF02786
Domain	CbamoylP_synth_lsu-like_ATP-bd	ACACB PCCA	6.45e-04	7	105	2	IPR005479
Domain	BC-like_N	ACACB PCCA	6.45e-04	7	105	2	IPR005481
Domain	Biotin_carb_N	ACACB PCCA	6.45e-04	7	105	2	PF00289
Domain	ARM-like	SETX CAND2 RTTN TOGARAM1 HEATR1 AP5Z1 TTI1	8.33e-04	270	105	7	IPR011989
Domain	Leu-rich_rpt	FLII ISLR2 LRCH2 MFHAS1 LRRC2 PRELP PHLPP1	8.51e-04	271	105	7	IPR001611
Domain	Kinase-like_dom	MOK MAP4K3 CLK4 ADCK1 ROR2 PAK4 STYK1 IRAK2 PTK2B STK10	9.53e-04	542	105	10	IPR011009
Domain	Band3_cytoplasmic_dom	SLC4A3 SLC4A9	1.10e-03	9	105	2	IPR013769
Domain	Band_3_cyto	SLC4A3 SLC4A9	1.10e-03	9	105	2	PF07565
Domain	Biotin_lipoyl	ACACB PCCA	1.10e-03	9	105	2	PF00364
Domain	-	SLC4A3 SLC4A9	1.10e-03	9	105	2	3.40.1100.10
Domain	HCO3_cotransp	SLC4A3 SLC4A9	1.37e-03	10	105	2	PF00955
Domain	HCO3_transpt_C	SLC4A3 SLC4A9	1.37e-03	10	105	2	IPR011531
Domain	PTrfase/Anion_transptr	SLC4A3 SLC4A9	1.37e-03	10	105	2	IPR016152
Domain	HCO3_transpt_euk	SLC4A3 SLC4A9	1.37e-03	10	105	2	IPR003020
Domain	Biotin_lipoyl	ACACB PCCA	1.37e-03	10	105	2	IPR000089
Domain	BIOTINYL_LIPOYL	ACACB PCCA	1.37e-03	10	105	2	PS50968
Domain	-	CAND2 RTTN TOGARAM1 HEATR1 AP5Z1 TTI1	1.60e-03	222	105	6	1.25.10.10
Domain	Single_hybrid_motif	ACACB PCCA	1.99e-03	12	105	2	IPR011053
Domain	-	FLII ISLR2 LRCH2 MFHAS1 LRRC2 PRELP PHLPP1	2.24e-03	321	105	7	3.80.10.10
Domain	-	ACACB PCCA	2.35e-03	13	105	2	3.40.50.20
Domain	L_dom-like	FLII ISLR2 LRCH2 MFHAS1 LRRC2 PRELP PHLPP1	2.53e-03	328	105	7	IPR032675
Domain	Dynein_HC_stalk	DNHD1 DNAH9	2.73e-03	14	105	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DNAH9	2.73e-03	14	105	2	IPR013602
Domain	TUDOR	TDRD15 TDRD7	2.73e-03	14	105	2	PF00567
Domain	ATP-grasp	ACACB PCCA	2.73e-03	14	105	2	IPR011761
Domain	DHC_N2	DNHD1 DNAH9	2.73e-03	14	105	2	PF08393
Domain	PreATP-grasp_dom	ACACB PCCA	2.73e-03	14	105	2	IPR016185
Domain	MT	DNHD1 DNAH9	2.73e-03	14	105	2	PF12777
Domain	ATP_GRASP	ACACB PCCA	2.73e-03	14	105	2	PS50975
Domain	ARM-type_fold	VPS11 CAND2 RTTN TOGARAM1 HEATR1 URB1 TTI1	3.04e-03	339	105	7	IPR016024
Domain	DHC_fam	DNHD1 DNAH9	3.13e-03	15	105	2	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DNAH9	3.13e-03	15	105	2	IPR004273
Domain	Dynein_heavy	DNHD1 DNAH9	3.13e-03	15	105	2	PF03028
Domain	-	ACACB PCCA	3.13e-03	15	105	2	3.30.1490.20
Domain	HEAT	CAND2 TOGARAM1 HEATR1	4.26e-03	58	105	3	IPR000357
Domain	ATP_grasp_subdomain_1	ACACB PCCA	4.52e-03	18	105	2	IPR013815
Domain	-	ACACB PCCA	4.52e-03	18	105	2	3.30.470.20
Pubmed	Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.36e-09	6	109	4	27092474
Pubmed	The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	6.33e-09	8	109	4	8530406
Pubmed	An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.14e-08	9	109	4	12412011
Pubmed	A genetic study of the suppressors of the Engrailed-1 cerebellar phenotype.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	6.39e-08	13	109	4	16884697
Pubmed	Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	6.39e-08	13	109	4	7957066
Pubmed	Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity.	LRCH2 MFHAS1 LRRC2	1.20e-07	4	109	3	20616063
Pubmed	Six members of the mouse forkhead gene family are developmentally regulated.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.21e-07	15	109	4	7689224
Pubmed	Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.21e-07	15	109	4	22045912
Pubmed	Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.61e-07	16	109	4	8861101
Pubmed	Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.61e-07	16	109	4	10208738
Pubmed	FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines.	FOXD4L6 FOXD4L5 FOXD4L4	2.98e-07	5	109	3	12234674
Pubmed	Functional equivalency between Otx2 and Otx1 in development of the rostral head.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	3.41e-07	19	109	4	9895322
Pubmed	Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	4.25e-07	20	109	4	12812790
Pubmed	Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	5.24e-07	21	109	4	9449667
Pubmed	Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	6.39e-07	22	109	4	17389379
Pubmed	Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	9.24e-07	24	109	4	11820816
Pubmed	A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	9.24e-07	24	109	4	29992973
Pubmed	Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	1.29e-06	26	109	4	15857913
Pubmed	Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	2.04e-06	29	109	4	22972626
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	FLII AKAP8 LRCH2 YTHDC2 SYBU EML5 FNIP1	8.98e-06	232	109	7	25515538
Pubmed	Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions.	ABCC3 ABCC2	9.73e-06	2	109	2	12704183
Pubmed	Altered regulation of hepatic efflux transporters disrupts acetaminophen disposition in pediatric nonalcoholic steatohepatitis.	ABCC3 ABCC2	9.73e-06	2	109	2	25788542
Pubmed	Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma.	ABCC3 ABCC2	9.73e-06	2	109	2	11745434
Pubmed	Immunohistochemical Assessment of the Expression of Biliary Transportation Proteins MRP2 and MRP3 in Hepatocellular Carcinoma and in Cholangiocarcinoma.	ABCC3 ABCC2	9.73e-06	2	109	2	29464551
Pubmed	Major glucuronide metabolites of testosterone are primarily transported by MRP2 and MRP3 in human liver, intestine and kidney.	ABCC3 ABCC2	9.73e-06	2	109	2	30959153
Pubmed	Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models.	ABCC3 ABCC2	9.73e-06	2	109	2	21841039
Pubmed	Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the in vivo elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate.	ABCC3 ABCC2	9.73e-06	2	109	2	19088030
Pubmed	Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia.	SLC12A3 TRPV5	9.73e-06	2	109	2	15902302
Pubmed	Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells.	YTHDC2 TET1	9.73e-06	2	109	2	37474847
Pubmed	Leucine-rich repeat (LRR) proteins: integrators of pattern recognition and signaling in immunity.	LRCH2 LRRC2	9.73e-06	2	109	2	21606681
Pubmed	Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.	RNASE9 SLC4A3 DNAH9	1.06e-05	14	109	3	24811271
Pubmed	Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.	TOGARAM1 ZZEF1 AP5Z1 TTI1	2.20e-05	52	109	4	9455477
Pubmed	β-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells.	ROR2 ATF2	2.91e-05	3	109	2	29453334
Pubmed	The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis.	ABCC3 ABCC2	2.91e-05	3	109	2	12628490
Pubmed	Na(+)/H(+) antiporter (NHE1) and lactate/H(+) symporters (MCTs) in pH homeostasis and cancer metabolism.	SLC9A1 SLC16A4	2.91e-05	3	109	2	26944480
Pubmed	Increased multidrug resistance-associated protein activity in mononuclear cells of patients with systemic lupus erythematosus.	ABCC3 ABCC2	2.91e-05	3	109	2	18799096
Pubmed	MicroRNA-30c-2-3p negatively regulates NF-κB signaling and cell cycle progression through downregulation of TRADD and CCNE1 in breast cancer.	TRADD CCNE1	2.91e-05	3	109	2	25732226
Pubmed	Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice.	ABCC3 ABCC2	2.91e-05	3	109	2	17273943
Pubmed	Involvement of multiple efflux transporters in hepatic disposition of fexofenadine.	ABCC3 ABCC2	2.91e-05	3	109	2	18245269
Pubmed	Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b.	ABCC3 ABCC2	2.91e-05	3	109	2	25952649
Pubmed	Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2.	ABCC3 ABCC2	2.91e-05	3	109	2	19443695
Pubmed	Application of multivariate statistical procedures to identify transcription factors that correlate with MRP2, 3, and 4 mRNA in adult human livers.	ABCC3 ABCC2	2.91e-05	3	109	2	19480556
Pubmed	Multidrug resistance proteins 2 and 3 provide alternative routes for hepatic excretion of morphine-glucuronides.	ABCC3 ABCC2	2.91e-05	3	109	2	17485564
Pubmed	Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo.	ABCC3 ABCC2	2.91e-05	3	109	2	19996279
Pubmed	Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function.	ABCC3 ABCC2	2.91e-05	3	109	2	17494643
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FLII ABCC3 MFHAS1 RTTN EXTL3 TEP1 ZZEF1 ARHGEF10L CCNE1 STK10 URB1 BCL2L13 GAREM1	4.37e-05	1105	109	13	35748872
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ISLR2 SETX CAND2 SPAST PAK4 ZZEF1 ARHGEF10L AP5Z1 TET1	4.52e-05	529	109	9	14621295
Pubmed	The Organic Anion-Transporting Peptide 2B1 Is Localized in the Basolateral Membrane of the Human Jejunum and Caco-2 Monolayers.	ABCC3 ABCC2	5.82e-05	4	109	2	28408210
Pubmed	PAK4 functions in tumor necrosis factor (TNF) alpha-induced survival pathways by facilitating TRADD binding to the TNF receptor.	TRADD PAK4	5.82e-05	4	109	2	16227624
Pubmed	Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress.	ABCC3 ABCC2	5.82e-05	4	109	2	18038766
Pubmed	Polymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance.	ABCC3 ABCC2	5.82e-05	4	109	2	25162314
Pubmed	Inhibition of tetramethylpyrazine on P-gp, MRP2, MRP3 and MRP5 in multidrug resistant human hepatocellular carcinoma cells.	ABCC3 ABCC2	5.82e-05	4	109	2	19956884
Pubmed	Regulation of mRNA expression of MDR1, MRP1, MRP2 and MRP3 by prototypical microsomal enzyme inducers in primary cultures of human and rat hepatocytes.	ABCC3 ABCC2	5.82e-05	4	109	2	16946557
Pubmed	[Genetic study for diabetic microvascular complications--recent advances and future perspectives].	ACACB SLC12A3	5.82e-05	4	109	2	23156397
Pubmed	Genome-scale study of transcription factor expression in the branching mouse lung.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	6.01e-05	67	109	4	22711520
Pubmed	Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression.	SLC16A4 ABCC2	9.67e-05	5	109	2	20658178
Pubmed	Noxin promotes proliferation of breast cancer cells via P38-ATF2 signaling pathway.	ATF2 CCNE1	9.67e-05	5	109	2	28618963
Pubmed	Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.	ABCC3 ABCC2	1.45e-04	6	109	2	22232210
Pubmed	Genetic variations associated with diabetic nephropathy and type II diabetes in a Japanese population.	SLC12A3 AGT	1.45e-04	6	109	2	17653210
Pubmed	Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese.	TRADD ERAP1	1.45e-04	6	109	2	21068102
Pubmed	Expressions of hepatobiliary organic anion transporters and bilirubin-conjugating enzyme in differentiating embryonic stem cells.	ABCC3 ABCC2	1.45e-04	6	109	2	12951053
Pubmed	A human MAP kinase interactome.	SETX MAP4K3 TOM1L1 PAK4 EXTL3 SLC9A1 WDR44 GAREM1	1.52e-04	486	109	8	20936779
Pubmed	Genetic susceptibility to febrile seizures: case-control association studies.	SLC4A3 SLC9A1	2.02e-04	7	109	2	19854014
Pubmed	HIV-1 Nef binds with human GCC185 protein and regulates mannose 6 phosphate receptor recycling.	HEXB HEXD	2.02e-04	7	109	2	27105913
Pubmed	The internal Cdc20 binding site in BubR1 facilitates both spindle assembly checkpoint signalling and silencing.	MAD2L1BP ANAPC1	2.02e-04	7	109	2	25482201
Pubmed	Association of multi-drug resistance gene polymorphisms with pancreatic cancer outcome.	ABCC3 ABCC2	2.02e-04	7	109	2	20922799
Pubmed	The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity.	CAND2 PAQR6 P4HTM	2.52e-04	39	109	3	23864651
Pubmed	SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery.	VPS11 VIPAS39	2.69e-04	8	109	2	19109425
Pubmed	Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes.	VPS11 VIPAS39	2.69e-04	8	109	2	25783203
Pubmed	Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects.	SLC12A3 TRPV5	2.69e-04	8	109	2	33859252
Pubmed	Structural basis of Vps33A recruitment to the human HOPS complex by Vps16.	VPS11 VIPAS39	2.69e-04	8	109	2	23901104
Pubmed	Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.	ABCC3 ABCC2	2.69e-04	8	109	2	15802388
Pubmed	Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia.	ACSL6 FNIP1	2.69e-04	8	109	2	18804346
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ERAP1 EXTL3 URB1 PHLPP1	3.42e-04	105	109	4	9628581
Pubmed	Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity.	VPS11 VIPAS39	4.31e-04	10	109	2	26463206
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	ABCC3 VPS11 MAP4K3 PPFIBP2 RTTN PAK4 STK10 SLC9A1 ABCC2	4.46e-04	719	109	9	35337019
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	HEXB SETX IRAK2 TEP1 PTK2B TTI1	4.72e-04	313	109	6	20800603
Pubmed	Confirmation of genomewide association signals in Chinese Han population reveals risk loci for ischemic stroke.	UBR3 KCNK17	5.26e-04	11	109	2	19910543
Pubmed	Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions.	FOXD4L4 FOXD4L3	5.26e-04	11	109	2	12421752
Pubmed	Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice.	PTK2B AGT	5.26e-04	11	109	2	16374517
Pubmed	Genetic factors are relevant and independent determinants of antihypertensive drug effects in a multiracial population.	SLC12A3 AGT	5.26e-04	11	109	2	19779464
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	FLII VPS11 AKAP8 LRCH2 YTHDC2 HEATR1 MAD2L1BP URB1 TTI1	6.26e-04	754	109	9	33060197
Pubmed	Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.	CCNE1 PTK2B	7.42e-04	13	109	2	18206965
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	FLII AKAP8 YTHDC2 ATF2 EMSY STK10 ANAPC1 IQCK WDR44	7.53e-04	774	109	9	15302935
Pubmed	Hereditary Spastic Paraplegia Overview	SPAST AP5Z1 DDHD2	1.04e-03	63	109	3	20301682
Pubmed	The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.	SLC12A3 AGT	1.13e-03	16	109	2	15824464
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	FLII VPS11 LRCH2 VIPAS39 DDHD2	1.19e-03	251	109	5	29778605
Pubmed	SH3RF2 functions as an oncogene by mediating PAK4 protein stability.	TRADD PAK4	1.44e-03	18	109	2	24130170
Pubmed	Degradation of NLRP3 by p62-dependent-autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia.	FLII ARHGEF10L	1.78e-03	20	109	2	37072933
Pubmed	Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.	PAK4 PTK2B STK10	1.92e-03	78	109	3	17192257
Pubmed	Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?	MRPL37 RTTN P4HTM ANAPC1	2.06e-03	170	109	4	23314748
Pubmed	Comparative analysis of apoptosis and inflammation genes of mice and humans.	TRADD IRAK2 BCL2L13	2.06e-03	80	109	3	12819136
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	ABCC3 PPFIBP2 PAK4 FERMT1 STK10 SLC9A1 ABCC2	2.14e-03	569	109	7	30639242
Pubmed	Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.	ABCC3 ABCC2	2.16e-03	22	109	2	8894702
Pubmed	Diverse fates of paralogs following segmental duplication of telomeric genes.	FOXD4L4 FOXD4L3	2.16e-03	22	109	2	15233989
Pubmed	SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.	PDSS2 SPAST ROR2 STYK1 CCNE1 SLC16A4 CFAP74 SLC27A5 GAREM1	2.38e-03	915	109	9	32393512
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	FLII PDSS2 MRPL37 YTHDC2 SYBU HEATR1 ZZEF1 VIPAS39 DDHD2 IMP3 BCL2L13 WDR44	2.57e-03	1496	109	12	32877691
Pubmed	Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.	FOXD4L6 HEATR1 FOXD4L5 FOXD4L4 FOXD4L3	2.83e-03	306	109	5	18973680
Pubmed	USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.	ACACB PCCA IMP3	2.89e-03	90	109	3	35654790
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	DNHD1 MAP4K3 RTTN ZZEF1	2.90e-03	187	109	4	26460568
Cytoband	9q21.11	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	7.86e-07	30	109	4	9q21.11
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	ERAP1 HEATR1 PTK2B	9.72e-04	51	69	3	870
GeneFamily	ATP binding cassette subfamily C	ABCC3 ABCC2	1.09e-03	13	69	2	807
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MBOAT1 MFHAS1 MAP4K3 ARHGEF10L TMEM178A TRPV5 GAREM1	4.29e-07	189	109	7	90aae7e806882bebfad78a78e9a16cf56af3ecd4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MBOAT1 ROR2 ARHGEF10L TMEM178A TRPV5 GAREM1	3.18e-06	164	109	6	6fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MBOAT1 MAP4K3 PPFIBP2 TMEM178A TRPV5 SLC4A9	3.53e-06	167	109	6	edc5f04584b44f99ff9a62bbe0dab6fc044fb334
ToppCell	LPS_only-Epithelial_airway-airway_epithelial-Ciliated\|LPS_only / Treatment groups by lineage, cell group, cell type	MOK TTC16 CFAP54 P4HTM EML5 DNAH9	9.36e-06	198	109	6	6d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Mesenchymal\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	MOK NFKBID CCNE1 PTK2B SLC9A1 EML5	9.91e-06	200	109	6	be83f442179ba4217d12f0458059586ff3130991
Computational	Neighborhood of MSH3	GPR19 SPAST EXTL3 ATF2 SLC4A3 TTI1 IQCK	1.21e-04	243	50	7	MORF_MSH3
Disease	short QT syndrome (implicated_via_orthology)	SLC4A3 KCNH6	3.40e-05	3	100	2	DOID:0050793 (implicated_via_orthology)
Disease	bilirubin metabolic disorder (biomarker_via_orthology)	ABCC3 ABCC2	2.36e-04	7	100	2	DOID:2741 (biomarker_via_orthology)
Disease	colorectal cancer, particulate matter air pollution measurement	STK10 TRIM48	3.14e-04	8	100	2	EFO_0008255, MONDO_0005575
Disease	Heart Diseases	SLC4A3 AGT ABCC2	5.16e-04	46	100	3	C0018799
Disease	Cholestasis	ABCC3 MBOAT1 AGT ABCC2	5.44e-04	110	100	4	C0008370
Disease	glycochenodeoxycholate glucuronide (1) measurement	ABCC3 ABCC2	8.66e-04	13	100	2	EFO_0800474
Disease	X-24588 measurement	ABCC3 ABCC2	8.66e-04	13	100	2	EFO_0800898
Disease	anemia (implicated_via_orthology)	SLC4A3 SLC4A9	1.16e-03	15	100	2	DOID:2355 (implicated_via_orthology)
Disease	X-21441 measurement	ABCC3 ABCC2	1.50e-03	17	100	2	EFO_0800814
Disease	Left Ventricle Remodeling	SLC9A1 AGT	2.29e-03	21	100	2	C0600520
Disease	Ventricular Remodeling	SLC9A1 AGT	2.29e-03	21	100	2	C0600519
Disease	free cholesterol:total lipids ratio, intermediate density lipoprotein measurement	TDRD15 ACACB MFHAS1	3.15e-03	86	100	3	EFO_0008595, EFO_0020945

Protein segments in the cluster

Peptide	Gene	Start	Entry
KEPLHKALQMLLSQP	BCL2L13	116	Q9BXK5
QLSQRLLLILMPAKH	SLC4A3	1126	P48751
MPAKHQPDLLLLRHV	SLC4A9	866	Q96Q91
HLLNHVPRQMLLILK	ADCK1	426	Q86TW2
ILLLQDMLKNTPRGH	ARHGEF10L	466	Q9HCE6
QPLKNIYLPHVMLLA	CFAP54	2541	Q96N23
MLIPAQPQLLQRHLH	AKAP8	486	O43823
RMDNSKPHLIIPTLL	GPR19	6	Q15760
TPQHKMLRLRLPNLK	FERMT1	91	Q9BQL6
QHPLLQPKMRAILLD	CCNE1	136	P24864
MRLKAALTQQHPPVT	ATF2	276	P15336
RHLLPVMAKVVVLSP	AP5Z1	151	O43299
QSRNIVMHLPLPTKL	DNHD1	4721	Q96M86
AMQVRKLVGTQHPLL	PDSS2	81	Q86YH6
RMHLLEKQRNPEVIP	CBY3	196	A6NI87
KKLSPRTIHLTMPQL	AGT	361	P01019
QLLKMNHNRLGSLPR	ISLR2	126	Q6UXK2
HLAQMKGLQRSQILP	P4HTM	161	Q9NXG6
MAAPRQIPSHIVRLK	IQCK	1	Q8N0W5
NILRLPLNMLPQLIS	ABCC3	576	O15438
QKLMMTLRHPSLPLL	ACACB	1026	O00763
LMAPTLLPELHLLKQ	ANAPC1	1651	Q9H1A4
ARQMQKLPVAIPAHK	MAP4K3	636	Q8IVH8
LPPQMRRLVHLQTLV	FLII	166	Q13045
LLKHIMYQRQQLPLP	MAD2L1BP	76	Q15013
PLLQLVPHLHERRMK	NMU	126	P48645
HSQPAVQPRLKLLLM	MFHAS1	401	Q9Y4C4
VLLDQNLTPKLAHPM	IRAK2	341	O43187
PLHTAILALNVAMRP	NFKBID	156	Q8NI38
LITMAILQNPHKRLT	FOXD4L4	116	Q8WXT5
LITMAILQNPHKRLT	FOXD4L3	116	Q6VB84
LEPLPNNVVLTMKLH	HORMAD2	171	Q8N7B1
RILQLLQKPMPQGHA	KCNH6	846	Q9H252
PRHLAISNMPLVKSV	ERAP1	211	Q9NZ08
IPLNLVVLNRLGHLM	KCNK17	141	Q96T54
VLRNNKILPMHFPLH	GAREM1	286	Q9H706
PNREIIILHNPKLMV	DDHD2	156	O94830
RKLIHPVMVQHIQPA	HEXD	401	Q8WVB3
MRILDLPKNQISHLP	LRRC2	146	Q9BYS8
RLMSKVNPEPNVIHI	NSMF	446	Q6X4W1
LHKQLLNNILRAPMR	ABCC2	1056	Q92887
IQALRRLNPHPNILM	MOK	51	Q9UQ07
PPQQLMLSAALRTLK	PCCA	21	P05165
MLSLKLPQLLQVHQV	PAQR6	1	Q6TCH4
GIPMLNLLIHSLRNK	OR5J2	281	Q8NH18
PHRLQPDQLRAKMIL	MRPL37	301	Q9BZE1
AMLLNIPPQKTLLRR	PPFIBP2	761	Q8ND30
VPRMLSDLLVPHKVI	OR6V1	76	Q8N148
LKIHQIRSPPQLMLS	FNIP1	146	Q8TF40
MAQNQPKLSLPIRLL	EXTL3	146	O43909
EHKPPLLIRRNNMKI	C4orf17	296	Q53FE4
LIILFLPMKPQAHTQ	MBOAT1	466	Q6ZNC8
LPTVLLKLRMAQHLQ	IMP3	111	Q9NV31
SLNHPLAPVRILAMN	HEATR1	486	Q9H583
QLQHKLPQMPQLSIR	EMSY	986	Q7Z589
LPQMPQLSIRHQKLT	EMSY	991	Q7Z589
LSTNIRPMLGIKPHL	EML5	1311	Q05BV3
ASNERIPLNPTMKLL	DNAH9	2251	Q9NYC9
RILGPIPQHMIQKTR	CLK4	391	Q9HAZ1
LPQIPMLNLEARRSH	PTK2B	376	Q14289
LLVKMTPNLLHLAPE	HEXB	61	P07686
NLHMLRGQVPLVVKA	CAND2	426	O75155
KPDHPLMVSALLQLR	CFAP74	1551	Q9C0B2
VLPQQMGKLHSLREL	LRCH2	216	Q5VUJ6
MIRDNLPPRLKNLHK	PAK4	526	O96013
IILAIRFNPHLQTPM	OR1L8	46	Q8NGR8
QKVLLHMLSHPLPRV	RTTN	616	Q86VV8
SVLLHMPQPLNLALR	TRIM48	196	Q8IWZ4
LQPLNLGIIHTMKVL	TIGD6	311	Q17RP2
NLKPSLHPQMNLLAL	TOM1L1	356	O75674
MLKIHRSDPQLIVQL	TRADD	61	Q15628
LKHMPPNLQKVDLFR	GINS4	146	Q9BRT9
PQQMPDLLQHKRPEL	TDRD15	201	B5MCY1
KNRLMPLSHLPLRDS	TMEM178A	56	Q8NBL3
LITMAILQNPHKRLT	FOXD4L5	116	Q5VV16
LITMAILQNPHKRLT	FOXD4L6	116	Q3SYB3
PVHDQLQDPRLLKRM	SETX	2531	Q7Z333
LNLAHNILRKMPPRV	PRELP	226	P51888
ARSNPLILMRLQLPK	ROR2	271	Q01974
KRRVLIEPGMPLNHI	RNASE9	66	P60153
RLQLLEKMQPVLPFS	SPAST	191	Q9UBP0
PKASLQPPLQMHLSR	TDRD7	191	Q8NHU6
ILLVLQNRPLHKPMY	OR6B1	46	O95007
LMKHLRPTLAPVQLT	URB1	1926	O60287
KEQLMHQRLPTLPGI	TET1	1326	Q8NFU7
HRPKALQPPCNLLMQ	ACSL6	46	Q9UKU0
PPTSILEHLQRRKIM	STYK1	331	Q6J9G0
VLKHIENKNLMPPLL	VPS11	741	Q9H270
MDQLPQKNLLRLHPA	ARHGAP40	1	Q5TG30
PRLLQDTVQRLMLPH	TEP1	1146	Q99973
LNLVPSSMLLRPIHI	SLC16A4	186	O15374
LPKPAILTHERVLQM	SLC27A5	301	Q9Y2P5
PRLILRPHMPQQQHK	SYBU	26	Q9NX95
SLAPELQAQRMLAPK	WDR97	1411	A6NE52
PHHELNPMRVLLKIA	STK10	236	O94804
MLIQKQISHPLHPKI	ZNF546	196	Q86UE3
KLPTGINPLTLHIMR	WDR44	376	Q5JSH3
MRIPHLRGKFNLQLP	nan	46	A8MX80
PHKQRMPELQLIANG	SLC12A3	681	P55017
MQNIHPKSLPSERIL	SLC9A1	606	P19634
KHPRKASILNMPLVT	VIPAS39	321	Q9H9C1
MPLQELCLHTKLLAP	YTHDC2	771	Q9H6S0
PHMRIRLSNITPNIK	ZBED5	666	Q49AG3
LIQILMMPQPLRKDH	UBR3	1541	Q6ZT12
VLHNTQKALRHMPPL	ZZEF1	421	O43149
HNQLLELPPNLLMKA	PHLPP1	971	O60346
LLLNPKHPQARMLLQ	TTC16	231	Q8NEE8
KMIPLLRDHLSPIIN	TOGARAM1	1556	Q9Y4F4
IQPQLPLLMHLQAAM	UBQLN3	501	Q9H347
LHMLQQKRILESPLL	TRPV5	36	Q9NQA5
LHPHTPKVLEVMLRN	TTI1	711	O43156