Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium ion binding

SNED1 VLDLR SCUBE1 STAB2 FBN1 SCUBE2 SUSD1 DLL4 JAG1 SCUBE3 LRP4 LTBP1 LTBP2 ITGB1 LRP1B LDLR FBN3 EGFEM1P NOTCH2 LRP8

9.64e-167495220GO:0005509
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

VLDLR STAB2 LRP1B LDLR LRP8

4.20e-1016525GO:0005041
GeneOntologyMolecularFunctionextracellular matrix structural constituent

RELN FBN1 VWF COL19A1 LTBP1 LTBP2 TECTA MUC3A FBN3

1.25e-09188529GO:0005201
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

VLDLR STAB2 LRP1B LDLR LRP8

1.94e-0921525GO:0030228
GeneOntologyMolecularFunctionvery-low-density lipoprotein particle receptor activity

VLDLR LDLR LRP8

6.65e-084523GO:0030229
GeneOntologyMolecularFunctioncargo receptor activity

VLDLR STAB2 LRP1B LDLR EGFEM1P LRP8

8.66e-0885526GO:0038024
GeneOntologyMolecularFunctionlipoprotein particle binding

VLDLR STAB2 LDLR LRP8

2.02e-0635524GO:0071813
GeneOntologyMolecularFunctionprotein-lipid complex binding

VLDLR STAB2 LDLR LRP8

2.02e-0635524GO:0071814
GeneOntologyMolecularFunctionreelin receptor activity

VLDLR LRP8

6.65e-062522GO:0038025
GeneOntologyMolecularFunctionapolipoprotein binding

VLDLR LRP4 LRP8

1.84e-0520523GO:0034185
GeneOntologyMolecularFunctionextracellular matrix binding

ADAM9 LTBP1 LTBP2 ITGB1

3.90e-0573524GO:0050840
GeneOntologyMolecularFunctionNotch binding

SNED1 DLL4 JAG1

4.66e-0527523GO:0005112
GeneOntologyMolecularFunctionreceptor ligand activity

RELN FBN1 DEFB110 DLL4 WNT7A JAG1 WNT8B IL17F

7.84e-05547528GO:0048018
GeneOntologyMolecularFunctionstructural molecule activity

RELN FBN1 VWF COL19A1 JAG1 LTBP1 LTBP2 TECTA MUC3A FBN3

8.55e-058915210GO:0005198
GeneOntologyMolecularFunctionsignaling receptor activator activity

RELN FBN1 DEFB110 DLL4 WNT7A JAG1 WNT8B IL17F

8.57e-05554528GO:0030546
GeneOntologyMolecularFunctionintegrin binding

FBN1 VWF ADAM23 ADAM9 ITGB1

9.09e-05175525GO:0005178
GeneOntologyMolecularFunctionmicrofibril binding

LTBP1 LTBP2

9.91e-056522GO:0050436
GeneOntologyMolecularFunctionsignaling receptor regulator activity

RELN FBN1 DEFB110 DLL4 WNT7A JAG1 WNT8B IL17F

1.78e-04616528GO:0030545
GeneOntologyMolecularFunctioncytokine binding

SCUBE3 LTBP1 ITGB1 IL17F

7.42e-04157524GO:0019955
GeneOntologyMolecularFunctionlow-density lipoprotein particle binding

STAB2 LDLR

9.91e-0418522GO:0030169
GeneOntologyMolecularFunctioncollagen binding

VWF ADAM9 ITGB1

1.23e-0381523GO:0005518
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

CRIM1 TIE1 LTBP1

1.42e-0385523GO:0019199
GeneOntologyMolecularFunctionscavenger receptor activity

STAB2 EGFEM1P

2.24e-0327522GO:0005044
GeneOntologyMolecularFunctionlaminin binding

ADAM9 ITGB1

3.54e-0334522GO:0043236
GeneOntologyMolecularFunctionmetalloendopeptidase activity

ADAMTS19 ADAM23 ADAM9

3.77e-03120523GO:0004222
GeneOntologyMolecularFunctionmolecular function activator activity

RELN FBN1 DEFB110 DLL4 WNT7A JAG1 WNT8B LTF IL17F

4.20e-031233529GO:0140677
GeneOntologyMolecularFunctionglycosaminoglycan binding

STAB2 FBN1 LTBP2 LTF

5.18e-03268524GO:0005539
GeneOntologyMolecularFunctionfrizzled binding

WNT7A WNT8B

5.36e-0342522GO:0005109
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

FBN1 CRIM1 DLL4 ADAM9 SCUBE3 SHISA2 LTBP1 LTBP2 ITGB1 IL17F NOTCH2 STAT3 LRP8

1.29e-078505213GO:0071363
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

FBN1 CRIM1 ADAM9 SCUBE3 LTBP1 LTBP2 ITGB1 IL17F NOTCH2 STAT3

1.39e-074455210GO:0141091
GeneOntologyBiologicalProcesssemi-lunar valve development

ADAMTS19 TIE1 DLL4 JAG1 NOTCH2

1.63e-0750525GO:1905314
GeneOntologyBiologicalProcessresponse to growth factor

FBN1 CRIM1 DLL4 ADAM9 SCUBE3 SHISA2 LTBP1 LTBP2 ITGB1 IL17F NOTCH2 STAT3 LRP8

2.00e-078835213GO:0070848
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

FBN1 CRIM1 ADAM9 SCUBE3 LTBP1 LTBP2 ITGB1 IL17F NOTCH2 STAT3

2.90e-074825210GO:0007178
GeneOntologyBiologicalProcessheart valve morphogenesis

ADAMTS19 TIE1 DLL4 JAG1 NOTCH2

5.26e-0763525GO:0003179
GeneOntologyBiologicalProcessreelin-mediated signaling pathway

VLDLR RELN LRP8

8.39e-078523GO:0038026
GeneOntologyBiologicalProcessmorphogenesis of an epithelial sheet

DLL4 WNT7A JAG1 ITGB1 NOTCH2

1.18e-0674525GO:0002011
GeneOntologyBiologicalProcessheart valve development

ADAMTS19 TIE1 DLL4 JAG1 NOTCH2

1.54e-0678525GO:0003170
GeneOntologyBiologicalProcesscirculatory system development

ADAMTS19 SCUBE1 STAB2 FBN1 TIE1 APOLD1 DLL4 WNT7A JAG1 LTBP1 ITGB1 IL17F LDLR NOTCH2 STAT3

1.65e-0614425215GO:0072359
GeneOntologyBiologicalProcessblood vessel development

STAB2 TIE1 APOLD1 DLL4 WNT7A JAG1 LTBP1 ITGB1 IL17F LDLR NOTCH2 STAT3

2.53e-069295212GO:0001568
GeneOntologyBiologicalProcessaortic valve morphogenesis

ADAMTS19 TIE1 DLL4 JAG1

2.77e-0639524GO:0003180
GeneOntologyBiologicalProcessvasculature development

STAB2 TIE1 APOLD1 DLL4 WNT7A JAG1 LTBP1 ITGB1 IL17F LDLR NOTCH2 STAT3

3.91e-069695212GO:0001944
GeneOntologyBiologicalProcessregulation of osteoclast development

FBN1 LTF NOTCH2

4.25e-0613523GO:2001204
GeneOntologyBiologicalProcessblood vessel morphogenesis

STAB2 TIE1 APOLD1 DLL4 WNT7A JAG1 ITGB1 IL17F LDLR NOTCH2 STAT3

4.81e-068175211GO:0048514
GeneOntologyBiologicalProcessaortic valve development

ADAMTS19 TIE1 DLL4 JAG1

5.42e-0646524GO:0003176
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

FBN1 CRIM1 TIE1 ADAM9 SCUBE3 LRP4 SHISA2 LTBP1 LTBP2 ITGB1 IL17F NOTCH2 STAT3

5.45e-0611865213GO:0007167
GeneOntologyBiologicalProcesstransforming growth factor beta receptor signaling pathway

FBN1 ADAM9 LTBP1 LTBP2 ITGB1 IL17F STAT3

5.69e-06276527GO:0007179
GeneOntologyBiologicalProcesspositive regulation of kinase activity

VLDLR RELN FBN1 TIE1 ADAM9 LTF NOTCH2 LRP8

7.29e-06405528GO:0033674
GeneOntologyBiologicalProcessregulation of phosphate metabolic process

VLDLR RELN FBN1 MCPH1 TIE1 ADAM9 NSD1 LRP4 LTF ITGB1 LDLR NOTCH2 STAT3 LRP8

7.51e-0614215214GO:0019220
GeneOntologyBiologicalProcessregulation of phosphorus metabolic process

VLDLR RELN FBN1 MCPH1 TIE1 ADAM9 NSD1 LRP4 LTF ITGB1 LDLR NOTCH2 STAT3 LRP8

7.64e-0614235214GO:0051174
GeneOntologyBiologicalProcessregulation of cellular response to growth factor stimulus

FBN1 CRIM1 SCUBE3 SHISA2 LTBP1 ITGB1 IL17F NOTCH2

8.26e-06412528GO:0090287
GeneOntologyBiologicalProcessangiogenesis

STAB2 TIE1 APOLD1 DLL4 WNT7A JAG1 ITGB1 IL17F NOTCH2 STAT3

9.14e-067085210GO:0001525
GeneOntologyBiologicalProcesspositive regulation of phosphate metabolic process

VLDLR RELN FBN1 TIE1 ADAM9 LRP4 LTF ITGB1 NOTCH2 STAT3 LRP8

9.62e-068795211GO:0045937
GeneOntologyBiologicalProcesspositive regulation of phosphorus metabolic process

VLDLR RELN FBN1 TIE1 ADAM9 LRP4 LTF ITGB1 NOTCH2 STAT3 LRP8

9.62e-068795211GO:0010562
GeneOntologyBiologicalProcessdendrite morphogenesis

VLDLR RELN WNT7A LRP4 ITGB1 LRP8

1.02e-05198526GO:0048813
GeneOntologyBiologicalProcessventral spinal cord development

VLDLR RELN DLL4 LRP8

1.29e-0557524GO:0021517
GeneOntologyBiologicalProcessregulation of cell development

RELN FBN1 DLL4 WNT7A JAG1 LRP4 LTF ITGB1 LDLR NOTCH2 STAT3 LRP8

1.35e-0510955212GO:0060284
GeneOntologyBiologicalProcesspulmonary valve morphogenesis

ADAMTS19 JAG1 NOTCH2

1.67e-0520523GO:0003184
GeneOntologyBiologicalProcesscellular response to transforming growth factor beta stimulus

FBN1 ADAM9 LTBP1 LTBP2 ITGB1 IL17F STAT3

2.04e-05336527GO:0071560
GeneOntologyBiologicalProcesspositive regulation of phosphorylation

VLDLR RELN FBN1 TIE1 ADAM9 LRP4 LTF ITGB1 NOTCH2 LRP8

2.11e-057805210GO:0042327
GeneOntologyBiologicalProcesscell fate commitment

DLL4 WNT7A JAG1 WNT8B ITGB1 NOTCH2 STAT3

2.12e-05338527GO:0045165
GeneOntologyBiologicalProcessosteoclast development

FBN1 LTF NOTCH2

2.25e-0522523GO:0036035
GeneOntologyBiologicalProcessbone cell development

FBN1 LTF NOTCH2

2.25e-0522523GO:0098751
GeneOntologyBiologicalProcessresponse to transforming growth factor beta

FBN1 ADAM9 LTBP1 LTBP2 ITGB1 IL17F STAT3

2.33e-05343527GO:0071559
GeneOntologyBiologicalProcesspositive regulation of protein kinase activity

VLDLR RELN FBN1 ADAM9 LTF NOTCH2 LRP8

2.65e-05350527GO:0045860
GeneOntologyBiologicalProcesspositive regulation of transferase activity

VLDLR RELN FBN1 TIE1 ADAM9 LTF NOTCH2 LRP8

2.88e-05490528GO:0051347
GeneOntologyBiologicalProcesspulmonary valve development

ADAMTS19 JAG1 NOTCH2

2.95e-0524523GO:0003177
GeneOntologyBiologicalProcesstube development

STAB2 FBN1 TIE1 APOLD1 DLL4 WNT7A JAG1 MUC19 ITGB1 IL17F LDLR NOTCH2 STAT3

3.26e-0514025213GO:0035295
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

FBN1 LTBP1

3.73e-054522GO:0035583
GeneOntologyBiologicalProcessregulation of neurogenesis

RELN DLL4 WNT7A LRP4 ITGB1 LDLR NOTCH2 LRP8

4.10e-05515528GO:0050767
GeneOntologyBiologicalProcessregulation of phosphorylation

VLDLR RELN FBN1 MCPH1 TIE1 ADAM9 NSD1 LRP4 LTF ITGB1 NOTCH2 LRP8

4.14e-0512265212GO:0042325
GeneOntologyBiologicalProcessregulation of kinase activity

VLDLR RELN FBN1 MCPH1 TIE1 ADAM9 LTF NOTCH2 LRP8

4.83e-05686529GO:0043549
GeneOntologyBiologicalProcesspositive regulation of protein metabolic process

VLDLR RELN FBN1 ADAM9 WNT7A LRP4 LTF ITGB1 IL17F LDLR NOTCH2 STAT3 LRP8

4.90e-0514585213GO:0051247
GeneOntologyBiologicalProcessanimal organ morphogenesis

ADAMTS19 SCUBE2 DLL4 WNT7A JAG1 WNT8B MUC19 LRP4 LTF TECTA NOTCH2 STAT3

5.79e-0512695212GO:0009887
GeneOntologyBiologicalProcessanatomical structure formation involved in morphogenesis

RELN STAB2 TIE1 APOLD1 DLL4 ADAM9 WNT7A JAG1 ITGB1 IL17F NOTCH2 STAT3 LRP8

5.84e-0514835213GO:0048646
GeneOntologyBiologicalProcesspositive regulation of osteoblast differentiation

SCUBE2 JAG1 SCUBE3 LTF

7.16e-0588524GO:0045669
GeneOntologyBiologicalProcesspositive regulation of protein phosphorylation

VLDLR RELN FBN1 ADAM9 LRP4 LTF ITGB1 NOTCH2 LRP8

7.32e-05724529GO:0001934
GeneOntologyBiologicalProcesstube morphogenesis

STAB2 TIE1 APOLD1 DLL4 WNT7A JAG1 ITGB1 IL17F LDLR NOTCH2 STAT3

9.27e-0511255211GO:0035239
GeneOntologyBiologicalProcessciliary body morphogenesis

JAG1 NOTCH2

9.29e-056522GO:0061073
GeneOntologyBiologicalProcessnegative regulation of osteoclast development

FBN1 LTF

9.29e-056522GO:2001205
GeneOntologyBiologicalProcessendothelium development

SCUBE1 TIE1 APOLD1 DLL4 JAG1

9.40e-05182525GO:0003158
GeneOntologyBiologicalProcessheart development

ADAMTS19 SCUBE1 FBN1 TIE1 DLL4 JAG1 LTBP1 ITGB1 NOTCH2

1.03e-04757529GO:0007507
GeneOntologyBiologicalProcessregulation of osteoblast differentiation

SCUBE2 CRIM1 JAG1 SCUBE3 LTF

1.21e-04192525GO:0045667
GeneOntologyBiologicalProcessskeletal system development

FBN1 SCUBE2 COL19A1 MCPH1 WNT7A LTF IL17F NOTCH2

1.41e-04615528GO:0001501
GeneOntologyBiologicalProcessdorsal/ventral pattern formation

DLL4 WNT7A WNT8B LRP4

1.53e-04107524GO:0009953
GeneOntologyBiologicalProcessregulation of nervous system development

RELN DLL4 WNT7A LRP4 ITGB1 LDLR NOTCH2 LRP8

1.58e-04625528GO:0051960
GeneOntologyBiologicalProcessregulation of transferase activity

VLDLR RELN FBN1 MCPH1 TIE1 ADAM9 LTF NOTCH2 LRP8

1.71e-04810529GO:0051338
GeneOntologyBiologicalProcessmaintenance of protein location in extracellular region

FBN1 LTBP1

1.73e-048522GO:0071694
GeneOntologyBiologicalProcessamyloid-beta clearance by cellular catabolic process

LRP4 LDLR

1.73e-048522GO:0150094
GeneOntologyBiologicalProcessNotch signaling pathway

DLL4 JAG1 HERC2 NOTCH2 STAT3

1.84e-04210525GO:0007219
GeneOntologyBiologicalProcessnegative regulation of developmental process

FBN1 CRIM1 TIE1 WNT7A JAG1 LRP4 LTF ITGB1 IL17F LDLR STAT3

1.90e-0412205211GO:0051093
GeneOntologyBiologicalProcessdendrite development

VLDLR RELN WNT7A LRP4 ITGB1 LRP8

1.90e-04335526GO:0016358
GeneOntologyBiologicalProcesscardiac chamber development

ADAMTS19 DLL4 JAG1 LTBP1 NOTCH2

1.92e-04212525GO:0003205
GeneOntologyBiologicalProcessregulation of Notch signaling pathway

DLL4 JAG1 HERC2 STAT3

1.95e-04114524GO:0008593
GeneOntologyBiologicalProcesspositive regulation of smoothened signaling pathway

SCUBE1 SCUBE2 SCUBE3

1.99e-0445523GO:0045880
GeneOntologyBiologicalProcesspositive regulation of catalytic activity

VLDLR RELN FBN1 TIE1 ADAM9 LTF ITGB1 NOTCH2 STAT3 LRP8

2.12e-0410285210GO:0043085
GeneOntologyBiologicalProcessspinal cord development

VLDLR RELN DLL4 LRP8

2.30e-04119524GO:0021510
GeneOntologyBiologicalProcessregulation of transmembrane receptor protein serine/threonine kinase signaling pathway

FBN1 CRIM1 SCUBE3 LTBP1 IL17F NOTCH2

2.30e-04347526GO:0090092
GeneOntologyBiologicalProcesscell fate determination

WNT7A JAG1 NOTCH2

2.72e-0450523GO:0001709
GeneOntologyBiologicalProcessglomerular epithelial cell development

JAG1 NOTCH2

2.77e-0410522GO:0072310
GeneOntologyBiologicalProcesspositive regulation of chondrocyte proliferation

SCUBE2 LTF

2.77e-0410522GO:1902732
GeneOntologyBiologicalProcesspodocyte development

JAG1 NOTCH2

2.77e-0410522GO:0072015
GeneOntologyBiologicalProcessnegative regulation of cell differentiation

FBN1 CRIM1 WNT7A JAG1 LRP4 LTF ITGB1 LDLR STAT3

3.04e-04875529GO:0045596
GeneOntologyBiologicalProcesspositive regulation of Notch signaling pathway

DLL4 JAG1 STAT3

3.24e-0453523GO:0045747
GeneOntologyBiologicalProcessregulation of BMP signaling pathway

FBN1 CRIM1 SCUBE3 NOTCH2

3.32e-04131524GO:0030510
GeneOntologyBiologicalProcesssequestering of extracellular ligand from receptor

FBN1 LTBP1

3.38e-0411522GO:0035581
GeneOntologyBiologicalProcessartery development

DLL4 JAG1 LTBP1 LDLR

3.52e-04133524GO:0060840
GeneOntologyBiologicalProcesscardiac septum development

ADAMTS19 JAG1 LTBP1 NOTCH2

3.62e-04134524GO:0003279
GeneOntologyBiologicalProcessregulation of synapse organization

VLDLR RELN WNT7A LRP4 ITGB1 LRP8

4.12e-04387526GO:0050807
GeneOntologyBiologicalProcessregulation of synapse structure or activity

VLDLR RELN WNT7A LRP4 ITGB1 LRP8

4.59e-04395526GO:0050803
GeneOntologyBiologicalProcessregulation of protein phosphorylation

VLDLR RELN FBN1 ADAM9 NSD1 LRP4 LTF ITGB1 NOTCH2 LRP8

4.60e-0411335210GO:0001932
GeneOntologyBiologicalProcessextracellular regulation of signal transduction

FBN1 LTBP1

4.78e-0413522GO:1900115
GeneOntologyBiologicalProcessextracellular negative regulation of signal transduction

FBN1 LTBP1

4.78e-0413522GO:1900116
GeneOntologyBiologicalProcesspositive regulation of protein modification process

VLDLR RELN FBN1 ADAM9 LRP4 LTF ITGB1 NOTCH2 LRP8

5.02e-04937529GO:0031401
GeneOntologyBiologicalProcessdefense response to bacterium

STAB2 DEFB110 MUC19 LTF IL17F NOTCH2

5.24e-04405526GO:0042742
GeneOntologyBiologicalProcessbone development

FBN1 SCUBE2 MCPH1 LTF NOTCH2

5.26e-04264525GO:0060348
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

VLDLR RELN WNT7A LRP4 TECTA ITGB1 NOTCH2 LRP8

5.28e-04748528GO:0048667
GeneOntologyBiologicalProcesscell-substrate adhesion

SNED1 VWF ADAM9 JAG1 TECTA ITGB1

5.59e-04410526GO:0031589
GeneOntologyBiologicalProcesscell-matrix adhesion

SNED1 ADAM9 JAG1 TECTA ITGB1

5.82e-04270525GO:0007160
GeneOntologyBiologicalProcessendothelial cell differentiation

SCUBE1 TIE1 APOLD1 JAG1

6.74e-04158524GO:0045446
GeneOntologyBiologicalProcesscentral nervous system development

VLDLR RELN MCPH1 DLL4 ADAM23 WNT7A ITGB1 LDLR STAT3 LRP8

7.07e-0411975210GO:0007417
GeneOntologyBiologicalProcesscardiac chamber morphogenesis

ADAMTS19 DLL4 JAG1 NOTCH2

7.23e-04161524GO:0003206
GeneOntologyBiologicalProcesscardiac ventricle development

ADAMTS19 DLL4 JAG1 LTBP1

7.23e-04161524GO:0003231
GeneOntologyBiologicalProcessembryo development

TIE1 DLL4 WNT7A JAG1 WNT8B NSD1 LRP4 TECTA ITGB1 LRP1B NOTCH2

7.66e-0414375211GO:0009790
GeneOntologyBiologicalProcessregulation of myeloid cell differentiation

FBN1 JAG1 LTF NOTCH2 STAT3

7.79e-04288525GO:0045637
GeneOntologyBiologicalProcessregulation of protein kinase activity

VLDLR RELN FBN1 ADAM9 LTF NOTCH2 LRP8

8.14e-04611527GO:0045859
GeneOntologyBiologicalProcesslayer formation in cerebral cortex

RELN LRP8

8.28e-0417522GO:0021819
GeneOntologyBiologicalProcesspositive regulation of CREB transcription factor activity

RELN LRP8

9.29e-0418522GO:0032793
GeneOntologyBiologicalProcessosteoblast differentiation

SCUBE2 CRIM1 JAG1 SCUBE3 LTF

9.64e-04302525GO:0001649
GeneOntologyCellularComponentextracellular matrix

SNED1 ADAMTS19 RELN FBN1 FCGBP VWF COL19A1 WNT7A LTBP1 LTBP2 TECTA ITGB1 FBN3

6.74e-096565313GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

SNED1 ADAMTS19 RELN FBN1 FCGBP VWF COL19A1 WNT7A LTBP1 LTBP2 TECTA ITGB1 FBN3

6.99e-096585313GO:0030312
GeneOntologyCellularComponentcell surface

VLDLR SCUBE1 STAB2 VWF SCUBE2 ADAM9 WNT7A SCUBE3 LRP4 ASTN1 LTF ITGB1 LDLR NOTCH2 LRP8

6.45e-0811115315GO:0009986
GeneOntologyCellularComponentmicrofibril

FBN1 LTBP1 FBN3

4.32e-0613533GO:0001527
GeneOntologyCellularComponentGolgi lumen

MUC3B WNT7A MUC19 MUC3A

1.68e-04109534GO:0005796
GeneOntologyCellularComponentexternal side of plasma membrane

SCUBE1 STAB2 VWF ADAM9 ASTN1 ITGB1 LDLR

3.20e-04519537GO:0009897
GeneOntologyCellularComponentcollagen-containing extracellular matrix

RELN FBN1 VWF COL19A1 LTBP1 LTBP2 ITGB1

3.63e-04530537GO:0062023
GeneOntologyCellularComponentreceptor complex

VLDLR TIE1 ITGB1 LRP1B LDLR NOTCH2 LRP8

6.29e-04581537GO:0043235
GeneOntologyCellularComponentSchaffer collateral - CA1 synapse

WNT7A ITGB1 STAT3 LRP8

6.42e-04155534GO:0098685
GeneOntologyCellularComponentside of membrane

SCUBE1 STAB2 VWF ADAM9 ASTN1 TECTA ITGB1 LDLR

1.52e-03875538GO:0098552
GeneOntologyCellularComponentlipoprotein particle

VLDLR LDLR

5.57e-0344532GO:1990777
GeneOntologyCellularComponentplasma lipoprotein particle

VLDLR LDLR

5.57e-0344532GO:0034358
GeneOntologyCellularComponentplasma membrane raft

LRP4 LDLR LRP8

6.17e-03147533GO:0044853
GeneOntologyCellularComponentprotein-lipid complex

VLDLR LDLR

6.34e-0347532GO:0032994
HumanPhenoAortic valve stenosis

ADAMTS19 FBN1 VWF LTBP1 LTBP2 LDLR NOTCH2

4.01e-07113237HP:0001650
HumanPhenoFoot oligodactyly

DLL4 WNT7A LRP4

1.30e-0511233HP:0001849
HumanPhenoAbnormal aortic valve physiology

ADAMTS19 FBN1 VWF LTBP1 LTBP2 LDLR NOTCH2

1.42e-05192237HP:0031652
HumanPhenoAbnormal pulmonary artery morphology

ADAMTS19 FBN1 DLL4 JAG1 LTBP1 NOTCH2

1.98e-05133236HP:0030966
HumanPhenoAbnormal heart valve physiology

ADAMTS19 FBN1 VWF DLL4 LRP4 LTBP1 LTBP2 LDLR NOTCH2

3.33e-05403239HP:0031653
HumanPhenoMicrospherophakia

FBN1 LTBP2

1.16e-044232HP:0030961
HumanPhenoAbnormal pulmonary valve morphology

ADAMTS19 FBN1 DLL4 LRP4 LTBP2 NOTCH2

1.85e-04198236HP:0001641
HumanPhenoIridodonesis

FBN1 LTBP2

1.93e-045232HP:0100693
HumanPhenoSpherophakia

FBN1 LTBP2

1.93e-045232HP:0034375
HumanPhenoAbnormal aortic valve morphology

ADAMTS19 FBN1 VWF LTBP1 LTBP2 LDLR NOTCH2

1.96e-04289237HP:0001646
HumanPhenoAbnormal atrioventricular valve physiology

ADAMTS19 FBN1 DLL4 LTBP2 LDLR NOTCH2

2.91e-04215236HP:0031650
HumanPhenoAplasia of the toes

DLL4 WNT7A LRP4 NOTCH2

2.95e-0474234HP:0011306
HumanPhenoAbsent toe

DLL4 WNT7A LRP4 NOTCH2

2.95e-0474234HP:0010760
HumanPhenoPulmonic stenosis

ADAMTS19 FBN1 LRP4 LTBP2 NOTCH2

3.08e-04138235HP:0001642
HumanPhenoAplasia/hypoplasia involving bones of the hand

FBN1 DLL4 WNT7A JAG1 SCUBE3 LRP4 LTBP2 HERC2 NOTCH2

3.20e-04538239HP:0005927
HumanPhenoDolichocephaly

RELN FBN1 JAG1 NSD1 HERC2 NOTCH2

3.22e-04219236HP:0000268
HumanPhenoBrachydactyly

FBN1 DLL4 WNT7A JAG1 NSD1 SCUBE3 LRP4 LTBP1 LTBP2 NOTCH2

3.30e-046702310HP:0001156
HumanPhenoShort digit

FBN1 DLL4 WNT7A JAG1 NSD1 SCUBE3 LRP4 LTBP1 LTBP2 NOTCH2

3.38e-046722310HP:0011927
HumanPhenoBowing of the long bones

FBN1 WNT7A NSD1 LRP4 LTBP1 HERC2 NOTCH2

3.41e-04316237HP:0006487
HumanPhenoBrachydactyly (hand)

FBN1 DLL4 WNT7A JAG1 NSD1 LRP4 LTBP2 NOTCH2

3.80e-04430238HP:0100667
HumanPhenoAnomaly of the limb diaphyses

FBN1 WNT7A NSD1 LRP4 LTBP1 HERC2 NOTCH2

3.83e-04322237HP:0006504
HumanPhenoOligodactyly

DLL4 WNT7A LRP4

4.02e-0433233HP:0012165
HumanPhenoIncreased arm span

FBN1 NSD1

4.04e-047232HP:0012771
HumanPhenoAbnormal fingernail morphology

DLL4 NSD1 LRP4 IL17F NOTCH2 STAT3

4.19e-04230236HP:0001231
HumanPhenoAplasia/hypoplasia involving bones of the upper limbs

FBN1 DLL4 WNT7A JAG1 SCUBE3 LRP4 LTBP2 HERC2 NOTCH2

5.10e-04572239HP:0006496
HumanPhenoAbnormal diaphysis morphology

FBN1 WNT7A NSD1 LRP4 LTBP1 HERC2 NOTCH2

5.64e-04343237HP:0000940
HumanPhenoAbnormal heart valve morphology

ADAMTS19 FBN1 VWF DLL4 LRP4 LTBP1 LTBP2 LDLR NOTCH2

6.27e-04588239HP:0001654
HumanPhenoAbnormal atrioventricular valve morphology

ADAMTS19 FBN1 VWF DLL4 LTBP2 LDLR NOTCH2

6.37e-04350237HP:0006705
HumanPhenoHeart murmur

ADAMTS19 FBN1 LDLR

6.61e-0439233HP:0030148
HumanPhenoAbnormal pulmonary valve physiology

ADAMTS19 FBN1 LRP4 LTBP2 NOTCH2

6.65e-04163235HP:0031654
HumanPhenoPeripheral pulmonary artery stenosis

JAG1 LTBP1 NOTCH2

7.13e-0440233HP:0004969
HumanPhenoBowing of the legs

FBN1 WNT7A NSD1 LTBP1 HERC2 NOTCH2

7.13e-04254236HP:0002979
HumanPhenoTriangular face

FBN1 JAG1 NSD1 SCUBE3 NOTCH2

7.43e-04167235HP:0000325
HumanPhenoAbnormal toenail morphology

DLL4 WNT7A NSD1 LRP4 IL17F

7.43e-04167235HP:0008388
HumanPhenoLong nose

JAG1 SCUBE3 NOTCH2

7.67e-0441233HP:0003189
HumanPhenoAbnormal heart sound

ADAMTS19 FBN1 LDLR

8.23e-0442233HP:0031657
HumanPhenoAplasia/Hypoplasia of fingers

FBN1 DLL4 WNT7A JAG1 LRP4 LTBP2 NOTCH2

8.34e-04366237HP:0006265
HumanPhenoNail dysplasia

WNT7A NSD1 LRP4 IL17F NOTCH2 STAT3

8.75e-04264236HP:0002164
MousePhenofused phalanges

WNT7A SCUBE3 LRP4

1.70e-0516453MP:0008730
MousePhenoabnormal bone trabecula morphology

FBN1 SCUBE2 MCPH1 LRP4 NOTCH2

6.74e-05134455MP:0010867
MousePhenodecreased bone trabecula number

FBN1 SCUBE2 MCPH1 NOTCH2

7.36e-0570454MP:0010869
MousePhenoabnormal phalanx morphology

FBN1 WNT7A SCUBE3 LRP4

1.02e-0476454MP:0005306
MousePhenoabnormal posture

RELN FBN1 CRIM1 SCUBE3 LRP4 ITGB1

1.20e-04243456MP:0001504
MousePhenolens dislocation

CRIM1 LTBP2

1.51e-046452MP:0031428
MousePhenoincreased embryonic neuroepithelium thickness

SCUBE1 ITGB1

2.11e-047452MP:0012702
MousePhenoabnormal short-term spatial reference memory

RELN LDLR

2.11e-047452MP:0008431
MousePhenoabnormal hyaloid artery morphology

MCPH1 NOTCH2

2.11e-047452MP:0012537
MousePhenosyndactyly

CRIM1 WNT7A SCUBE3 LRP4

2.22e-0493454MP:0000564
MousePhenoabnormal capillary morphology

CRIM1 DLL4 LDLR NOTCH2

2.22e-0493454MP:0003658
MousePhenoabnormal bone volume

FBN1 SCUBE2 MCPH1 LRP4 NOTCH2

2.24e-04173455MP:0010874
MousePhenoabnormal metacarpal bone morphology

FBN1 SCUBE3 LRP4

2.24e-0437453MP:0003073
MousePhenoabnormal blood vessel physiology

VLDLR FBN1 VWF CRIM1 MCPH1 DLL4 ADAM9

2.41e-04394457MP:0000249
MousePhenoretina neovascularization

VLDLR DLL4 ADAM9

2.43e-0438453MP:0008852
MousePhenoabnormal cerebellum development

VLDLR RELN ASTN1 LRP8

2.51e-0496454MP:0000854
MousePhenodecreased circulating unsaturated transferrin level

LRP1B LDLR

2.80e-048452MP:0011897
MousePhenoabnormal vasculature physiology

VLDLR FBN1 VWF CRIM1 MCPH1 DLL4 ADAM9

2.81e-04404457MP:0031170
MousePhenodecreased bone volume

FBN1 SCUBE2 MCPH1 NOTCH2

2.93e-04100454MP:0010876
MousePhenopathological neovascularization

VLDLR MCPH1 DLL4 ADAM9

3.93e-04108454MP:0003711
MousePhenodecreased body fat mass

FBN1 SCUBE3 HERC2

4.30e-0446453MP:0014143
MousePhenopericardial effusion

FBN1 DLL4 ITGB1 NOTCH2

4.37e-04111454MP:0005312
MousePhenodecreased circulating transferrin level

LRP1B LDLR

4.49e-0410452MP:0011894
MousePhenoabnormal trabecular bone volume

SCUBE2 MCPH1 LRP4 NOTCH2

4.67e-04113454MP:0010877
MousePhenosmall cerebellum

VLDLR RELN ASTN1 LRP8

5.68e-04119454MP:0000852
MousePhenodecreased urine protein level

SCUBE3 STAT3

6.55e-0412452MP:0002963
MousePhenoabnormal lens topology

CRIM1 LTBP2

6.55e-0412452MP:0020486
MousePhenolethality during fetal growth through weaning, incomplete penetrance

RELN COL19A1 CRIM1 MCPH1 JAG1 SHISA2 LTBP1 HERC2 ITGB1 NOTCH2 STAT3

6.85e-0411244511MP:0011112
MousePhenoabnormal pericardium morphology

FBN1 DLL4 JAG1 ITGB1 NOTCH2

7.47e-04225455MP:0000288
DomainEGF

SNED1 VLDLR RELN SCUBE1 MUC3B STAB2 FBN1 FCGBP SCUBE2 TIE1 SUSD1 DLL4 ADAM23 ADAM9 JAG1 SCUBE3 LRP4 ASTN1 LTBP1 LTBP2 TECTA MUC3A LRP1B LDLR FBN3 NOTCH2 LRP8

7.82e-382355327SM00181
DomainEGF-like_dom

SNED1 VLDLR RELN SCUBE1 MUC3B STAB2 FBN1 FCGBP SCUBE2 TIE1 SUSD1 DLL4 ADAM23 ADAM9 JAG1 SCUBE3 LRP4 ASTN1 LTBP1 LTBP2 TECTA MUC3A LRP1B LDLR FBN3 NOTCH2 LRP8

4.01e-372495327IPR000742
DomainEGF_1

SNED1 VLDLR RELN SCUBE1 MUC3B STAB2 FBN1 SCUBE2 TIE1 SUSD1 DLL4 ADAM23 ADAM9 JAG1 SCUBE3 LRP4 ASTN1 LTBP1 LTBP2 MUC3A ITGB1 LRP1B LDLR FBN3 NOTCH2 LRP8

6.30e-352555326PS00022
DomainEGF-like_CS

SNED1 VLDLR RELN SCUBE1 MUC3B STAB2 FBN1 SCUBE2 TIE1 SUSD1 DLL4 ADAM23 ADAM9 JAG1 SCUBE3 LRP4 ASTN1 LTBP1 LTBP2 MUC3A ITGB1 LRP1B LDLR FBN3 NOTCH2 LRP8

1.18e-342615326IPR013032
DomainEGF_3

SNED1 VLDLR RELN SCUBE1 MUC3B STAB2 FBN1 SCUBE2 TIE1 SUSD1 DLL4 ADAM23 ADAM9 JAG1 SCUBE3 LRP4 ASTN1 LTBP1 LTBP2 MUC3A LRP1B LDLR FBN3 NOTCH2 LRP8

5.62e-342355325PS50026
DomainEGF_2

SNED1 VLDLR RELN SCUBE1 MUC3B STAB2 FBN1 SCUBE2 TIE1 SUSD1 DLL4 ADAM23 ADAM9 JAG1 SCUBE3 LRP4 ASTN1 LTBP1 LTBP2 MUC3A LRP1B LDLR FBN3 NOTCH2 LRP8

1.27e-322655325PS01186
DomainEGF_CA

SNED1 VLDLR SCUBE1 STAB2 FBN1 SCUBE2 SUSD1 DLL4 JAG1 SCUBE3 LRP4 LTBP1 LTBP2 LRP1B LDLR FBN3 NOTCH2 LRP8

6.79e-271225318SM00179
DomainEGF-like_Ca-bd_dom

SNED1 VLDLR SCUBE1 STAB2 FBN1 SCUBE2 SUSD1 DLL4 JAG1 SCUBE3 LRP4 LTBP1 LTBP2 LRP1B LDLR FBN3 NOTCH2 LRP8

9.27e-271245318IPR001881
DomainGrowth_fac_rcpt_

VLDLR SCUBE1 STAB2 FBN1 SCUBE2 CRIM1 TIE1 SUSD1 DLL4 JAG1 SCUBE3 LRP4 LTBP1 LTBP2 LRP1B LDLR FBN3 NOTCH2 LRP8

9.88e-271565319IPR009030
DomainASX_HYDROXYL

SNED1 VLDLR SCUBE1 FBN1 SCUBE2 SUSD1 DLL4 JAG1 SCUBE3 LRP4 LTBP1 LTBP2 LRP1B LDLR FBN3 NOTCH2 LRP8

1.62e-261005317PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

SNED1 VLDLR SCUBE1 FBN1 SCUBE2 SUSD1 DLL4 JAG1 SCUBE3 LRP4 LTBP1 LTBP2 LRP1B LDLR FBN3 NOTCH2 LRP8

4.69e-261065317IPR000152
DomainEGF_Ca-bd_CS

SNED1 VLDLR SCUBE1 FBN1 SCUBE2 SUSD1 JAG1 SCUBE3 LRP4 LTBP1 LTBP2 LRP1B LDLR FBN3 NOTCH2 LRP8

9.72e-25975316IPR018097
DomainEGF_CA

SNED1 VLDLR SCUBE1 FBN1 SCUBE2 SUSD1 JAG1 SCUBE3 LRP4 LTBP1 LTBP2 LRP1B LDLR FBN3 NOTCH2 LRP8

1.38e-24995316PS01187
DomainEGF_CA

VLDLR SCUBE1 FBN1 SCUBE2 SUSD1 JAG1 SCUBE3 LRP4 LTBP1 LTBP2 LRP1B LDLR FBN3 NOTCH2 LRP8

1.33e-23865315PF07645
DomainEGF

SNED1 VLDLR STAB2 SCUBE2 TIE1 DLL4 JAG1 SCUBE3 LRP4 LTBP1 LTBP2 TECTA LRP1B FBN3 NOTCH2 LRP8

8.28e-231265316PF00008
DomainEGF_extracell

RELN STAB2 TIE1 DLL4 ADAM23 ADAM9 JAG1 LTBP2 ITGB1 LRP1B

9.32e-16605310IPR013111
DomainEGF_2

RELN STAB2 TIE1 DLL4 ADAM23 ADAM9 JAG1 LTBP2 ITGB1 LRP1B

9.32e-16605310PF07974
DomaincEGF

SCUBE1 FBN1 SCUBE2 SCUBE3 LRP4 LTBP1 LRP1B FBN3

3.63e-1526538IPR026823
DomaincEGF

SCUBE1 FBN1 SCUBE2 SCUBE3 LRP4 LTBP1 LRP1B FBN3

3.63e-1526538PF12662
DomainVWC_out

FCGBP VWF CRIM1 JAG1 MUC19 TECTA

1.03e-1119536SM00215
DomainLdl_recept_b

VLDLR LRP4 LRP1B LDLR LRP8

2.98e-1014535PF00058
DomainLDLRB

VLDLR LRP4 LRP1B LDLR LRP8

2.98e-1014535PS51120
DomainLY

VLDLR LRP4 LRP1B LDLR LRP8

4.46e-1015535SM00135
DomainLDLR_classB_rpt

VLDLR LRP4 LRP1B LDLR LRP8

4.46e-1015535IPR000033
DomainVWC

FCGBP VWF CRIM1 JAG1 MUC19 TECTA

1.00e-0938536SM00214
DomainVWF_dom

FCGBP VWF CRIM1 JAG1 MUC19 TECTA

1.89e-0942536IPR001007
DomainTB

FBN1 LTBP1 LTBP2 FBN3

2.01e-097534PF00683
Domain-

FBN1 LTBP1 LTBP2 FBN3

4.01e-0985343.90.290.10
DomainTB

FBN1 LTBP1 LTBP2 FBN3

7.20e-099534PS51364
DomainTB_dom

FBN1 LTBP1 LTBP2 FBN3

7.20e-099534IPR017878
DomainEGF_3

SCUBE1 STAB2 SCUBE2 SCUBE3

2.81e-0812534PF12947
DomainTIL

FCGBP VWF MUC19 TECTA

2.81e-0812534PF01826
DomainEGF_dom

SCUBE1 STAB2 SCUBE2 SCUBE3

2.81e-0812534IPR024731
DomainC8

FCGBP VWF MUC19 TECTA

2.81e-0812534PF08742
DomainUnchr_dom_Cys-rich

FCGBP VWF MUC19 TECTA

4.05e-0813534IPR014853
DomainC8

FCGBP VWF MUC19 TECTA

4.05e-0813534SM00832
DomainTIL_dom

FCGBP VWF MUC19 TECTA

5.66e-0814534IPR002919
Domain-

VLDLR LRP4 LRP1B LDLR LRP8

8.12e-08395352.120.10.30
DomainLDLR_class-A_CS

VLDLR LRP4 LRP1B LDLR LRP8

9.25e-0840535IPR023415
DomainVWD

FCGBP VWF MUC19 TECTA

1.03e-0716534SM00216
DomainVWF_type-D

FCGBP VWF MUC19 TECTA

1.03e-0716534IPR001846
DomainVWFD

FCGBP VWF MUC19 TECTA

1.03e-0716534PS51233
DomainVWD

FCGBP VWF MUC19 TECTA

1.03e-0716534PF00094
DomainLdl_recept_a

VLDLR LRP4 LRP1B LDLR LRP8

1.70e-0745535PF00057
Domain-

VLDLR LRP4 LRP1B LDLR LRP8

1.90e-07465354.10.400.10
Domain6-blade_b-propeller_TolB-like

VLDLR LRP4 LRP1B LDLR LRP8

1.90e-0746535IPR011042
DomainLDLRA_1

VLDLR LRP4 LRP1B LDLR LRP8

2.37e-0748535PS01209
DomainLDLRA_2

VLDLR LRP4 LRP1B LDLR LRP8

2.63e-0749535PS50068
DomainLDrepeatLR_classA_rpt

VLDLR LRP4 LRP1B LDLR LRP8

2.63e-0749535IPR002172
DomainLDLa

VLDLR LRP4 LRP1B LDLR LRP8

2.63e-0749535SM00192
DomainhEGF

SNED1 JAG1 FBN3 NOTCH2

1.12e-0628534PF12661
DomainEphrin_rec_like

SCUBE1 SCUBE2 SCUBE3

3.50e-0611533PF07699
DomainVWFC_2

VWF CRIM1 MUC19 TECTA

3.97e-0638534PS50184
DomainTILa

FCGBP TECTA

2.37e-053532PF12714
DomainTILa_dom

FCGBP TECTA

2.37e-053532IPR025615
DomainFBN

FBN1 FBN3

2.37e-053532IPR011398
DomainDSL

DLL4 JAG1

4.72e-054532PF01414
DomainDSL

DLL4 JAG1

4.72e-054532SM00051
DomainEphrin_rec_like

SCUBE1 SCUBE2 SCUBE3

4.75e-0525533SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

SCUBE1 SCUBE2 SCUBE3

4.75e-0525533IPR011641
DomainACR

ADAMTS19 ADAM23 ADAM9

6.01e-0527533SM00608
DomainADAM_Cys-rich

ADAMTS19 ADAM23 ADAM9

6.01e-0527533IPR006586
DomainNIDO_dom

SNED1 TECTA

7.86e-055532IPR003886
DomainDSL

DLL4 JAG1

7.86e-055532IPR001774
DomainNIDO

SNED1 TECTA

7.86e-055532SM00539
DomainNIDO

SNED1 TECTA

7.86e-055532PF06119
DomainDSL

DLL4 JAG1

7.86e-055532PS51051
DomainNotch_ligand_N

DLL4 JAG1

7.86e-055532IPR011651
DomainNIDO

SNED1 TECTA

7.86e-055532PS51220
DomainMNNL

DLL4 JAG1

7.86e-055532PF07657
DomainPeptidase_M12B_N

ADAMTS19 ADAM23 ADAM9

1.83e-0439533IPR002870
DomainPep_M12B_propep

ADAMTS19 ADAM23 ADAM9

1.83e-0439533PF01562
DomainDISINTEGRIN_1

ADAMTS19 ADAM23 ADAM9

1.98e-0440533PS00427
DomainReprolysin

ADAMTS19 ADAM23 ADAM9

1.98e-0440533PF01421
DomainADAM_MEPRO

ADAMTS19 ADAM23 ADAM9

1.98e-0440533PS50215
DomainDISINTEGRIN_2

ADAMTS19 ADAM23 ADAM9

1.98e-0440533PS50214
DomainPeptidase_M12B

ADAMTS19 ADAM23 ADAM9

1.98e-0440533IPR001590
DomainDisintegrin_dom

ADAMTS19 ADAM23 ADAM9

2.13e-0441533IPR001762
DomainCUB

SCUBE1 SCUBE2 SCUBE3

3.62e-0449533PF00431
DomainCUB

SCUBE1 SCUBE2 SCUBE3

3.85e-0450533SM00042
DomainFol_N

SNED1 FCGBP

4.27e-0411532IPR003645
Domain-

STAB2 SUSD1

4.27e-04115322.40.155.10
DomainGFP-like

STAB2 SUSD1

4.27e-0411532IPR023413
DomainFOLN

SNED1 FCGBP

4.27e-0411532SM00274
Domain-

SCUBE1 SCUBE2 SCUBE3

4.32e-04525332.60.120.290
DomainCUB

SCUBE1 SCUBE2 SCUBE3

4.57e-0453533PS01180
DomainCUB_dom

SCUBE1 SCUBE2 SCUBE3

5.67e-0457533IPR000859
DomainSEA

MUC3B MUC3A

7.03e-0414532SM00200
DomainCTCK_1

VWF MUC19

1.17e-0318532PS01185
DomainADAM_CR

ADAM23 ADAM9

1.17e-0318532PF08516
DomainWnt

WNT7A WNT8B

1.31e-0319532IPR005817
DomainWnt_CS

WNT7A WNT8B

1.31e-0319532IPR018161
Domainwnt

WNT7A WNT8B

1.31e-0319532PF00110
DomainWNT1

WNT7A WNT8B

1.31e-0319532SM00097
DomainWNT1

WNT7A WNT8B

1.31e-0319532PS00246
Domain-

ADAM23 ADAM9

1.45e-03205324.10.70.10
DomainMetalloPept_cat_dom

ADAMTS19 ADAM23 ADAM9

1.57e-0381533IPR024079
Domain-

ADAMTS19 ADAM23 ADAM9

1.57e-03815333.40.390.10
DomainDisintegrin

ADAM23 ADAM9

1.60e-0321532PF00200
DomainDISIN

ADAM23 ADAM9

1.60e-0321532SM00050
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

SCUBE1 FBN1 VWF COL19A1 ADAM9 SCUBE3 LRP4 LTBP1 LTBP2 ITGB1 FBN3

2.32e-093004611M610
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBN1 LTBP1 LTBP2 ITGB1 FBN3

1.19e-0737465M27134
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBN1 LTBP1 LTBP2 ITGB1 FBN3

2.92e-0744465M26969
PathwayWP_NEUROGENESIS_REGULATION_IN_THE_OLFACTORY_EPITHELIUM

VLDLR RELN JAG1 STAT3 LRP8

1.09e-0657465M48326
PathwayBIOCARTA_REELIN_PATHWAY

VLDLR RELN LRP8

1.13e-067463MM1566
PathwayBIOCARTA_REELIN_PATHWAY

VLDLR RELN LRP8

1.13e-067463M22049
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

FBN1 LTBP1 LTBP2 FBN3

1.19e-0625464M39713
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

SCUBE1 FBN1 VWF COL19A1 SCUBE3 LTBP1 LTBP2 ITGB1

1.61e-06258468MM14572
PathwayPID_REELIN_PATHWAY

VLDLR RELN ITGB1 LRP8

1.92e-0628464M69
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

FBN1 LTBP1 LTBP2 ITGB1

3.34e-0632464MM14854
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

SCUBE1 FBN1 COL19A1 ADAM9 SCUBE3 FBN3

5.82e-06140466M587
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

FBN1 LTBP1 LTBP2 ITGB1

6.75e-0638464MM14874
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

FBN1 LTBP1 LTBP2 ITGB1

7.51e-0639464MM14601
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

DLL4 JAG1 NOTCH2

9.09e-0613463M47423
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

FBN1 LTBP1 LTBP2 ITGB1

1.60e-0547464M646
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

DLL4 WNT7A JAG1 WNT8B NOTCH2

3.93e-05118465M39852
PathwayWP_NOTCH_SIGNALING_WP61

DLL4 JAG1 NOTCH2 STAT3

4.52e-0561464M39540
PathwayREACTOME_NOTCH2_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

DLL4 JAG1 NOTCH2

4.79e-0522463M27210
PathwayWP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING

DLL4 JAG1 NOTCH2

9.00e-0527463M39545
PathwayPID_LIS1_PATHWAY

VLDLR RELN LRP8

1.01e-0428463M163
PathwayREACTOME_REELIN_SIGNALLING_PATHWAY

VLDLR RELN

1.04e-045462M27759
PathwayREACTOME_REELIN_SIGNALLING_PATHWAY

VLDLR RELN

1.04e-045462MM15504
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

FBN1 LTBP1 LTBP2 ITGB1

1.13e-0477464MM14670
PathwayWP_DELTANOTCH_SIGNALING_PATHWAY

DLL4 JAG1 NOTCH2 STAT3

1.44e-0482464MM15922
PathwayREACTOME_SIGNALING_BY_NOTCH2

DLL4 JAG1 NOTCH2

1.66e-0433463M604
PathwayWP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER

DLL4 WNT7A JAG1 WNT8B NOTCH2

1.71e-04161465M39770
PathwayREACTOME_SIGNALING_BY_NOTCH1_T_7_9_NOTCH1_M1580_K2555_TRANSLOCATION_MUTANT

DLL4 JAG1

2.16e-047462M27199
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

FBN1 LTBP1 LTBP2 ITGB1

2.44e-0494464M1041
PathwayKEGG_MEDICUS_REFERENCE_PLASMIN_MEDIATED_ACTIVATION_OF_LATENT_TGF_BETA

FBN1 LTBP1

2.88e-048462M47850
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_LIGAND_UBIQUITYLATION

DLL4 JAG1

3.70e-049462M47866
PathwayWP_NOTCH_SIGNALING_WP268

DLL4 JAG1 NOTCH2

4.19e-0445463M39571
PathwayWP_NOTCH_SIGNALING_PATHWAY

DLL4 JAG1 NOTCH2

4.47e-0446463MM15971
PathwayWP_VEGFAVEGFR2_SIGNALING

SCUBE2 APOLD1 DLL4 ADAM9 JAG1 ITGB1 STAT3

4.54e-04431467M39729
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

DLL4 JAG1 NOTCH2

4.77e-0447463M7946
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

SCUBE1 FBN1 COL19A1 SCUBE3

5.09e-04114464MM14571
PathwayREACTOME_NOTCH4_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

DLL4 JAG1

5.62e-0411462M27882
PathwayWP_PAFAH1B1_COPY_NUMBER_VARIATION

VLDLR RELN

5.62e-0411462M48106
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

FBN1 LTBP1 LTBP2 ITGB1

5.80e-04118464MM15588
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380

JAG1 NOTCH2

6.73e-0412462M47532
PathwayWP_FAMILIAL_HYPERLIPIDEMIA_TYPE_3

VLDLR LDLR

7.94e-0413462M42551
PathwayBIOCARTA_LIS1_PATHWAY

RELN LRP8

9.25e-0414462MM1531
PathwayWP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS

FBN1 LTBP1 STAT3

9.30e-0459463M39886
PathwayPID_NOTCH_PATHWAY

DLL4 JAG1 NOTCH2

9.30e-0459463M17
PathwayKEGG_MEDICUS_REFERENCE_RELN_VLDLR_PI3K_SIGNALING_PATHWAY

VLDLR RELN

1.06e-0315462M47663
PathwayREACTOME_SIGNALING_BY_NOTCH1_HD_DOMAIN_MUTANTS_IN_CANCER

DLL4 JAG1

1.06e-0315462M27202
PathwayWP_CANCER_PATHWAYS

DLL4 WNT7A JAG1 WNT8B ITGB1 NOTCH2 STAT3

1.18e-03507467M48302
PathwayKEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY

DLL4 JAG1

1.21e-0316462M47424
PathwayREACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN

VWF ITGB1

1.21e-0316462M9450
PathwayWP_NOTCH1_REGULATION_OF_ENDOTHELIAL_CELL_CALCIFICATION

DLL4 JAG1

1.37e-0317462M39389
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS19 MUC3A NOTCH2

1.40e-0368463M27303
PathwayWP_RAC1PAK1P38MMP2_PATHWAY

TIE1 ITGB1 STAT3

1.40e-0368463M39456
PathwayWP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES

VLDLR STAB2 LRP4 LRP1B LDLR LRP8

1.41e-03381466M48063
PathwayWP_NEPHROGENESIS

JAG1 NOTCH2

1.54e-0318462M40045
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_ACYLATION

WNT7A WNT8B

1.72e-0319462M47836
PathwayREACTOME_SIGNALING_BY_NOTCH3

DLL4 JAG1

1.72e-0319462MM15594
PathwayBIOCARTA_LIS1_PATHWAY

RELN LRP8

1.72e-0319462M22005
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

FBN1 LTBP1 LTBP2 ITGB1

1.84e-03161464M27871
PathwayREACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS

FBN1 VWF ITGB1

1.94e-0376463MM14867
PathwayREACTOME_SIGNALING_BY_NOTCH4

DLL4 JAG1 NOTCH2

2.40e-0382463M594
PathwayKEGG_ECM_RECEPTOR_INTERACTION

RELN VWF ITGB1

2.58e-0384463M7098
PathwayREACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS

FBN1 VWF ITGB1

2.66e-0385463M16441
PathwayREACTOME_WNT_LIGAND_BIOGENESIS_AND_TRAFFICKING

WNT7A WNT8B

2.98e-0325462MM14940
PathwayREACTOME_NOTCH3_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

DLL4 JAG1

2.98e-0325462M27879
PathwayREACTOME_WNT_LIGAND_BIOGENESIS_AND_TRAFFICKING

WNT7A WNT8B

3.22e-0326462M27239
PathwayBIOCARTA_ERK_PATHWAY

ITGB1 STAT3

3.47e-0327462M287
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_INHIBITOR

WNT7A WNT8B

3.73e-0328462M47835
PathwayBIOCARTA_ERK_PATHWAY

ITGB1 STAT3

3.73e-0328462MM1391
PathwayWP_NEURAL_CREST_DIFFERENTIATION

DLL4 ITGB1 NOTCH2

3.87e-0397463MM15926
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PTCH1_TO_HEDGEHOG_SIGNALING_PATHWAY

WNT7A WNT8B

4.00e-0329462M47372
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_SMO_TO_HEDGEHOG_SIGNALING_PATHWAY

WNT7A WNT8B

4.00e-0329462M47377
PathwayWP_NEURAL_CREST_DIFFERENTIATION

DLL4 ITGB1 NOTCH2

4.33e-03101463M39448
Pubmed

Reelin is a ligand for lipoprotein receptors.

VLDLR RELN LDLR LRP8

5.19e-12454410571240
Pubmed

PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide.

VLDLR RELN LDLR LRP8

2.59e-11554418675252
Pubmed

Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex.

VLDLR RELN NOTCH2 LRP8

7.76e-11654418957219
Pubmed

Reelin binds alpha3beta1 integrin and inhibits neuronal migration.

VLDLR RELN ITGB1 LRP8

7.76e-11654410939329
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

VLDLR LRP4 LRP1B LDLR LRP8

1.49e-102154521337463
Pubmed

Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.

VLDLR RELN LDLR LRP8

3.62e-10854410380922
Pubmed

Reelin together with ApoER2 regulates interneuron migration in the olfactory bulb.

VLDLR RELN LRP8

3.54e-09354323209795
Pubmed

Identification of a novel family of cell-surface proteins expressed in human vascular endothelium.

SCUBE1 SCUBE2 SCUBE3

3.54e-09354312270931
Pubmed

Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse.

VLDLR RELN LRP8

3.54e-09354318778775
Pubmed

C-Terminal Region Truncation of RELN Disrupts an Interaction with VLDLR, Causing Abnormal Development of the Cerebral Cortex and Hippocampus.

VLDLR RELN LRP8

3.54e-09354328123028
Pubmed

Abnormal positioning of granule cells alters afferent fiber distribution in the mouse fascia dentata: morphologic evidence from reeler, apolipoprotein E receptor 2-, and very low density lipoprotein receptor knockout mice.

VLDLR RELN LRP8

3.54e-09354311920707
Pubmed

Differential functions of ApoER2 and very low density lipoprotein receptor in Reelin signaling depend on differential sorting of the receptors.

RELN LDLR LRP8

3.54e-09354319948739
Pubmed

Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1.

VLDLR RELN LRP8

3.54e-09354312670700
Pubmed

Functional importance of covalent homodimer of reelin protein linked via its central region.

VLDLR RELN LRP8

3.54e-09354321844191
Pubmed

The relationship of serum SCUBE-1, -2 and -3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients.

SCUBE1 SCUBE2 SCUBE3

3.54e-09354331991528
Pubmed

Reelin controls neuronal positioning by promoting cell-matrix adhesion via inside-out activation of integrin α5β1.

VLDLR RELN LRP8

3.54e-09354323083738
Pubmed

Contributions of VLDLR and LRP8 in the establishment of retinogeniculate projections.

VLDLR RELN LRP8

3.54e-09354323758727
Pubmed

ApoER2 function in the establishment and maintenance of retinal synaptic connectivity.

VLDLR RELN LRP8

3.54e-09354321976526
Pubmed

Reelin and its receptors, VLDLR and ApoER2, in melanocytic nevi.

VLDLR RELN LRP8

3.54e-09354328255385
Pubmed

LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein.

FBN1 LTBP1 LTBP2

3.54e-09354317293099
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

VLDLR ITGB1 LRP1B LDLR NOTCH2 LRP8

1.19e-0810154623382219
Pubmed

Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity.

VLDLR RELN LRP8

1.41e-08454316481437
Pubmed

Disabled1 regulates the intracellular trafficking of reelin receptors.

VLDLR RELN LRP8

1.41e-08454315718228
Pubmed

The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development.

VLDLR RELN LRP8

1.41e-08454314724251
Pubmed

Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors.

VLDLR RELN LRP8

1.41e-08454317548821
Pubmed

Structural basis for specific recognition of reelin by its receptors.

VLDLR RELN LRP8

1.41e-08454320223215
Pubmed

Processing of Reelin by embryonic neurons is important for function in tissue but not in dissociated cultured neurons.

VLDLR RELN LRP8

1.41e-08454317442808
Pubmed

Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation.

VLDLR RELN LRP8

1.41e-08454310571241
Pubmed

Expression and regulation of reelin and its receptors in the enteric nervous system.

VLDLR RELN LRP8

1.41e-08454324844606
Pubmed

Reelin receptors in developing laminated brain structures of mouse and human.

VLDLR RELN LRP8

1.41e-08454315548227
Pubmed

FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors.

VLDLR LDLR LRP8

1.41e-08454322109552
Pubmed

Differential binding of ligands to the apolipoprotein E receptor 2.

VLDLR RELN LRP8

1.41e-08454312899622
Pubmed

Components of the reelin signaling pathway are expressed in the spinal cord.

VLDLR RELN LRP8

1.41e-08454314750162
Pubmed

Role for Reelin-induced cofilin phosphorylation in the assembly of sympathetic preganglionic neurons in the murine intermediolateral column.

VLDLR RELN LRP8

1.41e-08454321039973
Pubmed

Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning.

VLDLR RELN LRP8

1.41e-08454312167620
Pubmed

Clusterin is a ligand for apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and signals via the Reelin-signaling pathway.

VLDLR RELN LRP8

1.41e-08454324381170
Pubmed

Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient mice.

VLDLR RELN LRP8

1.41e-08454312687696
Pubmed

Reelin provides an inhibitory signal in the migration of gonadotropin-releasing hormone neurons.

VLDLR RELN LRP8

1.41e-08454316207762
Pubmed

Contribution of the Reelin signaling pathways to nociceptive processing.

VLDLR RELN LRP8

1.41e-08454318279306
Pubmed

Interaction of reelin signaling and Lis1 in brain development.

VLDLR RELN LRP8

3.53e-08554314578885
Pubmed

ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin.

VLDLR RELN LRP8

3.53e-08554317494763
Pubmed

Scube3 is expressed in multiple tissues during development but is dispensable for embryonic survival in the mouse.

SCUBE1 SCUBE2 SCUBE3

3.53e-08554323383134
Pubmed

Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission.

VLDLR RELN LRP8

3.53e-08554314985430
Pubmed

A Unique "Reversed" Migration of Neurons in the Developing Claustrum.

VLDLR RELN LRP8

3.53e-08554336631266
Pubmed

Splicing variations in the ligand-binding domain of ApoER2 results in functional differences in the binding properties to Reelin.

VLDLR RELN LRP8

3.53e-08554319167437
Pubmed

Mice with Dab1 or Vldlr insufficiency exhibit abnormal neonatal vocalization patterns.

VLDLR RELN LRP8

3.53e-08554327184477
Pubmed

Impact of the Reelin signaling cascade (ligands-receptors-adaptor complex) on cognition in schizophrenia.

VLDLR RELN LRP8

3.53e-08554322419519
Pubmed

Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice.

DLL4 JAG1 NOTCH2

3.53e-08554335064244
Pubmed

PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain.

VLDLR LDLR LRP8

7.05e-08654320453200
Pubmed

Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation.

VLDLR RELN LRP8

7.05e-08654321048135
Pubmed

Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus.

VLDLR RELN LRP8

7.05e-08654328484035
Pubmed

Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS.

VLDLR RELN LRP8

7.05e-08654310557205
Pubmed

Reelin controls the positioning of brainstem serotonergic raphe neurons.

VLDLR RELN LRP8

7.05e-08654330001399
Pubmed

Localization of ApoER2, VLDLR and Dab1 in radial glia: groundwork for a new model of reelin action during cortical development.

VLDLR RELN LRP8

7.05e-08654312586425
Pubmed

ApoER2 and VLDLr are required for mediating reelin signalling pathway for normal migration and positioning of mesencephalic dopaminergic neurons.

VLDLR RELN LRP8

7.05e-08654323976984
Pubmed

Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches.

DLL4 JAG1 NOTCH2

7.05e-08654319217325
Pubmed

Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex.

VLDLR RELN LRP8

7.05e-08654325308109
Pubmed

The Pafah1b complex interacts with the reelin receptor VLDLR.

VLDLR RELN LRP8

1.23e-07754317330141
Pubmed

High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons.

VLDLR RELN LRP8

1.23e-07754315249135
Pubmed

Disruption of Scube2 Impairs Endochondral Bone Formation.

SCUBE1 SCUBE2 SCUBE3

1.23e-07754325639508
Pubmed

Downregulation of functional Reelin receptors in projection neurons implies that primary Reelin action occurs at early/premigratory stages.

VLDLR RELN LRP8

1.23e-07754319710317
Pubmed

The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.

VLDLR LDLR LRP8

1.23e-07754312169628
Pubmed

Reelin activates SRC family tyrosine kinases in neurons.

VLDLR RELN LRP8

1.97e-07854312526740
Pubmed

Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice.

VLDLR RELN LRP8

1.97e-07854311856531
Pubmed

Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.

FBN1 VWF JAG1

2.95e-07954312122015
Pubmed

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.

DLL4 JAG1 NOTCH2

2.95e-07954316245338
Pubmed

Disruption of reelin signaling alters mammary gland morphogenesis.

VLDLR RELN LRP8

2.95e-07954321266412
Pubmed

Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3.

VLDLR RELN LRP8

2.95e-07954319129405
Pubmed

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.

VLDLR LDLR LRP8

2.95e-07954320005821
Pubmed

Proteolytic cleavage of transmembrane cell adhesion molecule L1 by extracellular matrix molecule Reelin is important for mouse brain development.

VLDLR RELN LRP8

4.21e-071054329127326
Pubmed

Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.

DLL4 JAG1 NOTCH2

4.21e-071054323665443
Pubmed

Reelin Can Modulate Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Neurons via the Canonical Pathway.

VLDLR RELN LRP8

4.21e-071054330127721
Pubmed

Dynamics of Notch pathway expression during mouse testis post-natal development and along the spermatogenic cycle.

DLL4 JAG1 NOTCH2

4.21e-071054324015274
Pubmed

Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum.

VLDLR RELN LRP8

4.21e-071054320809939
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

VLDLR RELN FBN1 VWF CRIM1 ADAM23 ADAM9 LRP4 ASTN1 HERC2 LRP1B STAT3

5.01e-071285541235914814
Pubmed

Localization of reelin signaling pathway components in murine midbrain and striatum.

VLDLR RELN LRP8

5.79e-071154325418135
Pubmed

Reelin signaling is necessary for a specific step in the migration of hindbrain efferent neurons.

VLDLR RELN LRP8

5.79e-071154315703280
Pubmed

Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.

DLL4 JAG1 NOTCH2

7.71e-071254315465494
Pubmed

Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1.

VWF TIE1 DLL4 JAG1

9.60e-074854428924218
Pubmed

Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

DLL4 JAG1 NOTCH2

1.00e-061354311578869
Pubmed

Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.

VWF JAG1 NOTCH2

1.00e-061354320558824
Pubmed

Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration.

VLDLR RELN LRP8

1.27e-061454321460838
Pubmed

Stage-specific association of apolipoprotein A-I and E in developing mouse retina.

VLDLR LDLR LRP8

1.27e-061454317389516
Pubmed

Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.

DLL4 JAG1 NOTCH2

1.27e-061454314757642
Pubmed

Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system.

VLDLR RELN LRP8

1.59e-061554324449842
Pubmed

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.

DLL4 JAG1 NOTCH2

1.59e-061554312971992
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

FBN1 CRIM1 ADAM9 LRP4 LTBP1 LTBP2 ITGB1 LRP1B LDLR NOTCH2 LRP8

1.95e-061201541135696571
Pubmed

Expression of Notch pathway components in fetal and adult mouse small intestine.

DLL4 JAG1 NOTCH2

1.95e-061654312617809
Pubmed

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

DLL4 JAG1 NOTCH2

1.95e-061654317273555
Pubmed

Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.

MUC19 HERC2 STAT3

1.95e-061654319068216
Pubmed

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.

TIE1 DLL4 WNT7A JAG1

2.22e-065954421421844
Pubmed

Decreased generation of C-terminal fragments of ApoER2 and increased reelin expression in Alzheimer's disease.

RELN LRP8

2.37e-06254229442527
Pubmed

Latent transforming growth factor-β binding proteins (LTBP-1 and LTBP-2) and gingiva keratinization.

LTBP1 LTBP2

2.37e-06254225858550
Pubmed

Association analysis of polymorphic CGG repeat in 5' UTR of the reelin and VLDLR genes with schizophrenia.

VLDLR RELN

2.37e-06254212363388
Pubmed

A neuronal VLDLR variant lacking the third complement-type repeat exhibits high capacity binding of apoE containing lipoproteins.

VLDLR LDLR

2.37e-06254219393635
Pubmed

The N-Terminal Region of Fibrillin-1 Mediates a Bipartite Interaction with LTBP1.

FBN1 LTBP1

2.37e-06254228669633
Pubmed

The expression profile of Jagged1 and Delta-like 4 in hepatocellular carcinoma.

DLL4 JAG1

2.37e-06254230660174
Pubmed

Clinical features, outcomes, and genetic analysis in Korean children with Alagille syndrome.

JAG1 NOTCH2

2.37e-06254225676721
Pubmed

Renal involvement and the role of Notch signalling in Alagille syndrome.

JAG1 NOTCH2

2.37e-06254223752887
Pubmed

The reelin receptors VLDLR and ApoER2 regulate sensorimotor gating in mice.

VLDLR LRP8

2.37e-06254217261317
InteractionNTN5 interactions

FBN1 LRP4 LTBP1 LRP1B LDLR NOTCH2

2.84e-1124526int:NTN5
InteractionZNF408 interactions

VLDLR FBN1 LRP4 LTBP1 LTBP2 LRP1B LDLR NOTCH2

3.41e-09145528int:ZNF408
InteractionZFP41 interactions

FBN1 LRP4 LTBP1 LRP1B LDLR NOTCH2

7.19e-0957526int:ZFP41
InteractionIGFL3 interactions

VLDLR ADAM9 LRP4 LRP1B LDLR NOTCH2

3.85e-0875526int:IGFL3
InteractionFBXO2 interactions

SNED1 FBN1 SUSD1 ADAM23 ADAM9 WNT7A JAG1 ITGB1 LRP1B NOTCH2

8.22e-084115210int:FBXO2
InteractionSCUBE1 interactions

SCUBE1 SCUBE2 SCUBE3

1.61e-075523int:SCUBE1
InteractionRELN interactions

VLDLR RELN ITGB1 LRP8

6.62e-0727524int:RELN
InteractionFBN2 interactions

FBN1 WNT7A LTBP1 LTBP2 NOTCH2

6.90e-0765525int:FBN2
InteractionST14 interactions

VLDLR FBN1 CRIM1 ADAM9 GALNT6 LDLR NOTCH2

9.85e-07207527int:ST14
InteractionZNF778 interactions

LRP4 ZNF778 LTBP2

2.63e-0611523int:ZNF778
InteractionVLDLR interactions

VLDLR RELN LDLR LRP8

3.03e-0639524int:VLDLR
InteractionIGSF5 interactions

LRP4 LDLR NOTCH2

5.78e-0614523int:IGSF5
InteractionDEFB123 interactions

LRP4 LRP1B LDLR

8.86e-0616523int:DEFB123
InteractionMFAP5 interactions

FBN1 VWF JAG1 LDLR

9.73e-0652524int:MFAP5
InteractionDYRK1A interactions

SNED1 VLDLR FBN1 CRIM1 ADAM23 ADAM9 LRP4 LRP1B NOTCH2

1.05e-05552529int:DYRK1A
InteractionSCUBE2 interactions

SCUBE1 SCUBE2

3.91e-054522int:SCUBE2
InteractionFEZF1 interactions

LRP4 HERC2 LRP1B

5.07e-0528523int:FEZF1
InteractionSNX17 interactions

VLDLR ITGB1 LDLR LRP8

5.66e-0581524int:SNX17
InteractionLRP8 interactions

VLDLR RELN LDLR LRP8

7.16e-0586524int:LRP8
InteractionEPPIN interactions

ADAM9 LTF

9.73e-056522int:EPPIN
InteractionLRPAP1 interactions

VLDLR LRP4 LRP1B LDLR LRP8

9.95e-05180525int:LRPAP1
InteractionDLK2 interactions

ADAM9 LDLR STAT3

1.09e-0436523int:DLK2
InteractionEDDM3A interactions

SUSD1 GALNT6 LDLR

1.18e-0437523int:EDDM3A
InteractionZNF594 interactions

LTBP2 NOTCH2

1.36e-047522int:ZNF594
InteractionCD36 interactions

VLDLR ITGB1 LDLR

1.39e-0439523int:CD36
InteractionDAB1 interactions

VLDLR RELN LDLR LRP8

1.67e-04107524int:DAB1
InteractionSCUBE3 interactions

SCUBE1 SCUBE3

1.81e-048522int:SCUBE3
InteractionZNF398 interactions

LRP4 LTBP2 NOTCH2

1.86e-0443523int:ZNF398
InteractionZNF480 interactions

LTBP2 NOTCH2

2.32e-049522int:ZNF480
InteractionSLC25A36 interactions

LDLR STAT3

2.32e-049522int:SLC25A36
InteractionZKSCAN2 interactions

LTBP2 NOTCH2

2.32e-049522int:ZKSCAN2
InteractionPATE1 interactions

SUSD1 ADAM9 LRP1B

2.75e-0449523int:PATE1
InteractionFOXD4L6 interactions

LRP1B LDLR NOTCH2

2.75e-0449523int:FOXD4L6
InteractionZNF766 interactions

LTBP2 NOTCH2

2.90e-0410522int:ZNF766
InteractionZSCAN21 interactions

LRP4 LTBP2 LRP1B NOTCH2

3.32e-04128524int:ZSCAN21
InteractionFBLN1 interactions

MCPH1 WNT7A ITGB1 NOTCH2

3.42e-04129524int:FBLN1
InteractionNPNT interactions

SCUBE3 NOTCH2

3.54e-0411522int:NPNT
InteractionNDUFAF6 interactions

GALNT6 LDLR

3.54e-0411522int:NDUFAF6
InteractionVCAN interactions

FBN1 ITGB1 IL17F

3.66e-0454523int:VCAN
InteractionEFNB3 interactions

VLDLR RELN LRP8

3.87e-0455523int:EFNB3
InteractionMYLIP interactions

VLDLR LDLR LRP8

4.08e-0456523int:MYLIP
InteractionZNF555 interactions

LTBP2 NOTCH2

4.24e-0412522int:ZNF555
InteractionZNF563 interactions

LRP4 LRP1B

4.24e-0412522int:ZNF563
InteractionMFAP2 interactions

FBN1 JAG1

4.24e-0412522int:MFAP2
InteractionZNF611 interactions

LTBP2 NOTCH2

4.24e-0412522int:ZNF611
InteractionANKRD36B interactions

VLDLR LRP4 LRP1B

5.00e-0460523int:ANKRD36B
InteractionZNF709 interactions

LTBP2 NOTCH2

5.00e-0413522int:ZNF709
InteractionPHKB interactions

HERC2 ITGB1 RAVER1

5.77e-0463523int:PHKB
InteractionRNASE4 interactions

LRP1B NOTCH2

5.83e-0414522int:RNASE4
InteractionRAB25 interactions

ADAM9 MUC19 ITGB1 NOTCH2 LRP8

5.94e-04265525int:RAB25
InteractionITGA3 interactions

RELN ADAM9 ITGB1

7.21e-0468523int:ITGA3
InteractionTIMP2 interactions

FBN1 CRIM1 LTBP1 LTF ITGB1

7.25e-04277525int:TIMP2
InteractionZNF260 interactions

LTBP2 NOTCH2

7.66e-0416522int:ZNF260
InteractionZNF628 interactions

LTBP2 NOTCH2

7.66e-0416522int:ZNF628
InteractionLGALS3BP interactions

GALNT6 HERC2 ITGB1 STAT3 RAVER1

8.37e-04286525int:LGALS3BP
InteractionADAM2 interactions

ADAM23 ADAM9

8.66e-0417522int:ADAM2
InteractionNEURL1 interactions

DLL4 JAG1

8.66e-0417522int:NEURL1
InteractionZNF708 interactions

LTBP2 NOTCH2

9.73e-0418522int:ZNF708
Cytoband7q22

RELN MUC3B MUC3A

1.26e-05385437q22
GeneFamilyLow density lipoprotein receptors

VLDLR LRP4 LRP1B LDLR LRP8

5.20e-1113405634
GeneFamilyCD molecules|Mucins

MUC3B MUC19 MUC3A

1.30e-0521403648
GeneFamilyLatent transforming growth factor beta binding proteins

LTBP1 LTBP2

2.86e-054402628
GeneFamilyWnt family|Endogenous ligands

WNT7A WNT8B

7.97e-0419402360
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ADAM23 ADAM9

1.62e-032740247
GeneFamilyFibronectin type III domain containing

SNED1 TIE1 ASTN1

5.29e-03160403555
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

SNED1 SUSD1

7.05e-03574021179
GeneFamilyPHD finger proteins

BAZ2B NSD1

1.69e-029040288
CoexpressionNABA_MATRISOME

SNED1 ADAMTS19 RELN SCUBE1 FBN1 VWF SCUBE2 COL19A1 CRIM1 ADAM23 ADAM9 WNT7A WNT8B MUC19 SCUBE3 LTBP1 LTBP2 TECTA MUC3A IL17F FBN3

2.21e-1610265321M5889
CoexpressionNABA_MATRISOME

SNED1 ADAMTS19 RELN SCUBE1 FBN1 VWF SCUBE2 COL19A1 CRIM1 ADAM23 ADAM9 WNT7A WNT8B MUC19 SCUBE3 LTBP1 LTBP2 TECTA IL17F EGFEM1P

2.53e-1510085320MM17056
CoexpressionNABA_CORE_MATRISOME

SNED1 RELN FBN1 VWF COL19A1 CRIM1 LTBP1 LTBP2 TECTA EGFEM1P

1.50e-102705310MM17057
CoexpressionNABA_ECM_GLYCOPROTEINS

SNED1 RELN FBN1 VWF CRIM1 LTBP1 LTBP2 TECTA EGFEM1P

1.61e-10191539MM17059
CoexpressionNABA_CORE_MATRISOME

SNED1 RELN FBN1 VWF COL19A1 CRIM1 LTBP1 LTBP2 TECTA FBN3

1.80e-102755310M5884
CoexpressionNABA_ECM_GLYCOPROTEINS

SNED1 RELN FBN1 VWF CRIM1 LTBP1 LTBP2 TECTA FBN3

2.03e-10196539M3008
CoexpressionNABA_MATRISOME_ASSOCIATED

ADAMTS19 SCUBE1 SCUBE2 ADAM23 ADAM9 WNT7A WNT8B MUC19 SCUBE3 MUC3A IL17F

2.53e-077515311M5885
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3

SNED1 ADAMTS19 RELN SCUBE1 SCUBE2 COL19A1 DLL4 WNT7A JAG1 SCUBE3 SHISA2 GALNT6

1.19e-0610745312M1941
CoexpressionNABA_MATRISOME_ASSOCIATED

ADAMTS19 SCUBE1 SCUBE2 ADAM23 ADAM9 WNT7A WNT8B MUC19 SCUBE3 IL17F

1.92e-067385310MM17058
CoexpressionHORIUCHI_WTAP_TARGETS_UP

VLDLR FBN1 APOLD1 ADAM23 JAG1 PCGF5 PDZD2

2.86e-06309537M1973
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

DLL4 JAG1 NOTCH2

4.29e-0616533MM1296
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

DLL4 JAG1 NOTCH2

4.29e-0616533M2207
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HENDO

VWF CRIM1 TIE1 APOLD1 DLL4 JAG1 ITGB1 LDLR STAT3 LRP8

9.85e-068885310M39049
CoexpressionHU_FETAL_RETINA_FIBROBLAST

SNED1 SCUBE1 FBN1 JAG1 SHISA2 ITGB1 NOTCH2

1.20e-05385537M39264
CoexpressionWONG_ADULT_TISSUE_STEM_MODULE

VLDLR RELN VWF CRIM1 TIE1 LRP4 ASTN1 LTBP1 LTBP2

1.29e-05721539M1999
CoexpressionJONES_OVARY_ENDOTHELIAL

VWF CRIM1 TIE1 JAG1 ITGB1

1.91e-05162535M48350
CoexpressionVART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP

STAB2 TIE1 DLL4 JAG1 NOTCH2

1.97e-05163535M12112
CoexpressionAIZARANI_LIVER_C20_LSECS_3

RELN STAB2 CRIM1 TIE1 APOLD1 ADAM9

2.84e-05295536M39121
CoexpressionJONES_OVARY_NK_CELL

FBN1 CRIM1 TIE1 ITGB1

3.20e-0589534M48353
CoexpressionBENPORATH_EED_TARGETS

RELN COL19A1 DLL4 WNT7A STK32B SCUBE3 ASTN1 SHISA2 LTBP2 PDZD2

4.45e-0510595310M7617
CoexpressionCLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_DN

FBN1 LTBP1 LTBP2

4.88e-0535533M11788
CoexpressionHALLMARK_APICAL_JUNCTION

FBN1 VWF ADAM23 ADAM9 ITGB1

5.24e-05200535M5915
CoexpressionGSE20715_WT_VS_TLR4_KO_24H_OZONE_LUNG_DN

RELN FBN1 VWF TUT1 LTBP2

5.24e-05200535M4354
CoexpressionCLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_DN

FBN1 LTBP1 LTBP2

5.32e-0536533MM1212
CoexpressionNABA_SECRETED_FACTORS

SCUBE1 SCUBE2 WNT7A WNT8B SCUBE3 IL17F

6.06e-05338536MM17064
CoexpressionNABA_SECRETED_FACTORS

SCUBE1 SCUBE2 WNT7A WNT8B SCUBE3 IL17F

6.57e-05343536M5883
CoexpressionNABA_MATRISOME_HIGHLY_METASTATIC_BREAST_CANCER

SNED1 VWF ADAM9

7.88e-0541533M47988
CoexpressionFAN_EMBRYONIC_CTX_BIG_GROUPS_BRAIN_ENDOTHELIAL

VWF TIE1 APOLD1 JAG1 ITGB1 PDZD2

9.25e-05365536M39018
CoexpressionBRUNEAU_HEART_GREAT_VESSELS_AND_VALVULOGENESIS

JAG1 NOTCH2

1.11e-048532M9884
CoexpressionHOSHIDA_LIVER_CANCER_SUBCLASS_S1

FBN1 FCGBP ADAM9 LTBP2 LTF

1.12e-04235535M5311
CoexpressionZHAN_MULTIPLE_MYELOMA_LB_UP

SCUBE1 ITGB1 PCGF5

1.19e-0447533M14744
CoexpressionJONES_OVARY_MAST_CELL

CRIM1 TIE1 JAG1

1.19e-0447533M48356
CoexpressionSASAI_RESISTANCE_TO_NEOPLASTIC_TRANSFROMATION

VLDLR FBN1 LTBP2

1.43e-0450533M1259
CoexpressionDESCARTES_FETAL_THYMUS_VASCULAR_ENDOTHELIAL_CELLS

RELN STAB2 VWF TIE1

1.44e-04131534M40316
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HRGL3

CRIM1 ADAM9 WNT7A MUC19 LRP1B NOTCH2 STAT3

1.50e-04574537M39056
CoexpressionSASAI_RESISTANCE_TO_NEOPLASTIC_TRANSFROMATION

VLDLR FBN1 LTBP2

1.61e-0452533MM1118
CoexpressionGSE3720_UNSTIM_VS_PMA_STIM_VD1_GAMMADELTA_TCELL_DN

ADAMTS19 MCPH1 TIE1 SHISA2

1.62e-04135534M6344
CoexpressionVART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN

TIE1 WNT7A IL17F NOTCH2

1.62e-04135534M5825
CoexpressionCHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_CDC25_DN

ADAM23 LTBP2 STAT3

1.80e-0454533M5312
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HPERIC

FBN1 APOLD1 ADAM9 JAG1 ITGB1 NOTCH2 STAT3 PDZD2

1.83e-04795538M39050
CoexpressionLU_AGING_BRAIN_UP

VWF BAZ2B LRP4 LTBP1 ITGB1

1.90e-04263535M5547
CoexpressionHE_LIM_SUN_FETAL_LUNG_C7_MID_SCHWANN_CELL

VLDLR RELN COL19A1 ADAM9 JAG1

2.07e-04268535M45796
CoexpressionHALLMARK_UV_RESPONSE_DN

VLDLR LTBP1 LDLR NOTCH2

2.08e-04144534M5942
CoexpressionBENPORATH_SUZ12_TARGETS

FBN1 DLL4 WNT7A STK32B ASTN1 SHISA2 LTBP2 NOTCH2 PDZD2

2.09e-041035539M9898
CoexpressionCHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_CDC25_DN

ADAM23 LTBP2 STAT3

2.11e-0457533MM463
CoexpressionSASAKI_TARGETS_OF_TP73_AND_TP63

JAG1 ITGB1

2.61e-0412532M17374
CoexpressionGSE7509_FCGRIIB_VS_TNFA_IL1B_IL6_PGE_STIM_DC_DN

SCUBE1 STAB2 BAZ2B SHISA2

2.68e-04154534M6824
CoexpressionBENPORATH_ES_WITH_H3K27ME3

FBN1 DLL4 WNT7A STK32B SCUBE3 ASTN1 LTBP2 PCGF5 PDZD2

3.62e-041115539M10371
CoexpressionAIZARANI_LIVER_C9_LSECS_1

RELN STAB2 CRIM1 TIE1 APOLD1

3.70e-04304535M39113
CoexpressionGSE37605_FOXP3_FUSION_GFP_VS_IRES_GFP_TREG_NOD_DN

NSD1 TECTA MUC3A LDLR

3.99e-04171534M8820
CoexpressionJONES_OVARY_PERICYTE

FBN1 CRIM1 JAG1 ITGB1

4.08e-04172534M48351
CoexpressionCUI_DEVELOPING_HEART_TRABECULAR_ATRIAL_CARDIOMYOCYTE

RELN JAG1 LTBP1 ITGB1

4.74e-04179534M39308
CoexpressionFARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL

VLDLR SCUBE2 ADAM9 STK32B PDZD2

5.15e-04327535M4008
CoexpressionMOREIRA_RESPONSE_TO_TSA_DN

WNT7A NOTCH2

6.01e-0418532M3506
CoexpressionGSE46242_CTRL_VS_EGR2_DELETED_TH1_CD4_TCELL_DN

VLDLR CRIM1 STK32B STAT3

6.54e-04195534M9706
CoexpressionONDER_CDH1_SIGNALING_VIA_CTNNB1

FBN1 LTBP1 LTBP2

6.63e-0484533M15484
CoexpressionMTOR_UP.N4.V1_UP

VLDLR MCPH1 ADAM9 LDLR

6.67e-04196534M2757
CoexpressionGSE46606_UNSTIM_VS_CD40L_IL2_IL5_DAY3_STIMULATED_BCELL_UP

FBN1 APOLD1 BAZ2B HERC2

6.67e-04196534M9867
CoexpressionVERRECCHIA_RESPONSE_TO_TGFB1_C1

ADAM9 NOTCH2

6.71e-0419532M16026
CoexpressionHEVNER_CORTEX_VASCULAR_ENDOTHELIAL_CELLS

VWF DLL4

6.71e-0419532MM420
CoexpressionGSE22033_UNTREATED_VS_MRL24_TREATED_MEF_DN

SNED1 GALNT6 ITGB1 STAT3

6.80e-04197534M7696
CoexpressionGSE22886_NAIVE_CD8_TCELL_VS_NKCELL_DN

CRIM1 BAZ2B LTF NOTCH2

6.80e-04197534M4421
CoexpressionGSE3337_CTRL_VS_4H_IFNG_IN_CD8POS_DC_DN

LTBP2 HERC2 PCGF5 STAT3

7.19e-04200534M5099
CoexpressionGSE3039_CD4_TCELL_VS_NKT_CELL_UP

LTF NOTCH2 LRP8 PDZD2

7.19e-04200534M6426
CoexpressionGSE27786_NKTCELL_VS_NEUTROPHIL_DN

SNED1 SUSD1 STK32B STAT3

7.19e-04200534M4869
CoexpressionGSE2826_WT_VS_XID_BCELL_DN

VWF COL19A1 TIE1 ASTN1

7.19e-04200534M4897
CoexpressionGSE5589_LPS_VS_LPS_AND_IL6_STIM_IL6_KO_MACROPHAGE_45MIN_UP

VWF ADAM9 SHISA2 GALNT6

7.19e-04200534M6620
CoexpressionGSE17721_CTRL_VS_CPG_4H_BMDC_DN

DLL4 TUT1 LDLR NOTCH2

7.19e-04200534M3763
CoexpressionGSE3203_INFLUENZA_INF_VS_IFNB_TREATED_LN_BCELL_UP

ADAM23 SCUBE3 LTBP1 LDLR

7.19e-04200534M6790
CoexpressionGSE17721_CPG_VS_GARDIQUIMOD_8H_BMDC_DN

ADAM23 ADAM9 ITGB1 LRP8

7.19e-04200534M3893
CoexpressionAtlasStromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4

RELN STAB2 FBN1 CRIM1 TIE1 APOLD1 DLL4 JAG1 ASTN1 LTBP1 LTBP2

9.09e-094395311GSM777059_500
CoexpressionAtlasStromal Cells, LEC.SLN, gp38+ CD31+, Lymph Node, avg-4

RELN STAB2 FBN1 CRIM1 TIE1 APOLD1 DLL4 JAG1 LTBP1 LTBP2

1.43e-074505310GSM777063_500
CoexpressionAtlasECTO blastocyst_vs_ECTO cord blood-Confounder_removed-fold2.0_adjp0.05

RELN SCUBE2 ASTN1 SHISA2 LTBP1 LTBP2 FBN3

4.32e-07189537PCBC_ratio_ECTO blastocyst_vs_ECTO cord blood_cfr-2X-p05
CoexpressionAtlasEctoderm Differentiated Cells_vs_Mesoderm Day 5-Confounder_removed-fold2.0_adjp0.05

SCUBE1 FBN1 SCUBE2 ADSS2 ADAM23 JAG1 WNT8B SCUBE3 LRP4 ASTN1 LTBP2 NOTCH2 STAT3

5.16e-079675313PCBC_ratio_ECTO_vs_MESO-5_cfr-2X-p05
CoexpressionAtlaskidney_P3_CapMes_Crym_k-means-cluster#4_top-relative-expression-ranked_200

JAG1 SCUBE3 LRP4 LTBP1 NOTCH2

5.89e-0765535gudmap_kidney_P3_CapMes_Crym_k4_200
CoexpressionAtlaskidney_P3_CapMes_Crym_top-relative-expression-ranked_200

ADAM23 JAG1 SCUBE3 LRP4 LTBP1 NOTCH2

3.53e-06166536gudmap_kidney_P3_CapMes_Crym_200
CoexpressionAtlaskidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_500

VLDLR CRIM1 JAG1 SCUBE3 LRP4 LTBP1 NOTCH2 PDZD2

6.02e-06398538gudmap_kidney_P4_CapMesRenVes_Crym_500
CoexpressionAtlasJC_hmvEC_top-relative-expression-ranked_1000_k-means-cluster#4

SNED1 RELN VWF CRIM1 TIE1 DLL4 LTBP2 GALNT6

1.02e-05428538JC_hmvEC_1000_K4
CoexpressionAtlasEctoderm Differentiated Cells_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05

SCUBE1 FBN1 SCUBE2 ADAM23 ADAM9 JAG1 WNT8B SCUBE3 LRP4 ASTN1 LTBP2 NOTCH2

1.04e-0510755312PCBC_ratio_ECTO_vs_DE_cfr-2X-p05
CoexpressionAtlaskidney_P0_JuxtaGlom_Ren1_top-relative-expression-ranked_1000

VLDLR RELN FBN1 CRIM1 ADAM23 ADAM9 JAG1 SCUBE3 LTBP1 ITGB1 NOTCH2

1.17e-059055311gudmap_kidney_P0_JuxtaGlom_Ren1_1000
CoexpressionAtlaskidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_1000

VLDLR FBN1 CRIM1 SUSD1 JAG1 SCUBE3 LRP4 LTBP1 NOTCH2 PDZD2

2.03e-057835310gudmap_kidney_P4_CapMesRenVes_Crym_1000
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_induced-Ectoderm_fromBlastocyst-derived-humanEmbryonicStemCells_top-relative-expression-ranked_1000

ADAMTS19 RELN SCUBE1 SCUBE2 WNT8B MUC19 SCUBE3 ASTN1 SHISA2 MUC3A FBN3

2.36e-059765311PCBC_ECTO_blastocyst_1000
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_induced-Ectoderm_fromBlastocyst-derived-humanEmbryonicStemCells_top-relative-expression-ranked_500

ADAMTS19 RELN SCUBE1 SCUBE2 WNT8B SCUBE3 ASTN1 FBN3

2.59e-05487538PCBC_ECTO_blastocyst_500
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_induced-Ectoderm_top-relative-expression-ranked_500

ADAMTS19 SCUBE1 SCUBE2 WNT8B SCUBE3 ASTN1 SHISA2 FBN3

2.91e-05495538PCBC_ECTO_500
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_induced-Ectoderm_from_inducedPluripotentialStemCells_derived from_from_fibroblast_top-relative-expression-ranked_500

ADAMTS19 SCUBE1 SCUBE2 WNT8B SCUBE3 ASTN1 SHISA2 FBN3

2.99e-05497538PCBC_ECTO_fibroblast_500
CoexpressionAtlasDevelopingKidney_e12.5_renal vesicle_emap-27679_k-means-cluster#2_top-relative-expression-ranked_500

JAG1 WNT8B SCUBE3 LRP4 LTBP1

3.37e-05148535gudmap_developingKidney_e12.5_renal vesicle_500_k2
CoexpressionAtlaskidney_P3_CapMes_Crym_top-relative-expression-ranked_500

CRIM1 ADAM23 JAG1 SCUBE3 LRP4 LTBP1 NOTCH2

3.56e-05370537gudmap_kidney_P3_CapMes_Crym_500
CoexpressionAtlasEctoderm Differentiated Cells_vs_Pluripotent Stem Cells-Confounder_removed-fold2.0_adjp0.05

SCUBE1 FBN1 SCUBE2 ADAM9 JAG1 WNT8B SCUBE3 ASTN1 SHISA2 LTBP1 LTBP2 FBN3 NOTCH2

4.77e-0514665313PCBC_ratio_ECTO_vs_SC_cfr-2X-p05
CoexpressionAtlasStem Cells, SC.STSL.BM, CD117+ IL7R- CD150- CD48- AA4.1+ CD43+, Bone marrow, avg-3

VLDLR TIE1 SUSD1 LTF

6.03e-0585534GSM399454_100
CoexpressionAtlasStem Cells, SC.LTSL.BM, IgM- CD24- CD117+ IL7R- CD150+ CD48- AA4.1+ CD43+, Bone marrow, avg-2

VWF TIE1 SUSD1 LTF

6.31e-0586534GSM399442_100
CoexpressionAtlaskidney_P4_CapMesRenVes_Crym_top-relative-expression-ranked_200

CRIM1 JAG1 SCUBE3 LRP4 LTBP1

7.48e-05175535gudmap_kidney_P4_CapMesRenVes_Crym_200
CoexpressionAtlasStromal Cells, LEC.MLN, gp38+ CD31+, Lymph Node, avg-4

STAB2 FBN1 TIE1 APOLD1

7.87e-0591534GSM777059_100
CoexpressionAtlaskidney_P3_CapMes_Crym_top-relative-expression-ranked_1000

FBN1 CRIM1 ADAM23 JAG1 SCUBE3 LRP4 LTBP1 NOTCH2 PDZD2

8.88e-05749539gudmap_kidney_P3_CapMes_Crym_1000
CoexpressionAtlasJC_hmvEC_top-relative-expression-ranked_2500_k-means-cluster#1

SNED1 RELN VWF CRIM1 TIE1 APOLD1 DLL4 LTBP2 GALNT6 PCGF5

9.16e-059365310JC_hmvEC_2500_K1
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_reference_PulmonMicrovasc_top-relative-expression-ranked_100

RELN VWF TIE1 DLL4

1.09e-0499534PCBC_ctl_PulmonMicrovasc_100
CoexpressionAtlasStromal Cells, BEC.MLN, gp38- CD31+, Lymph Node, avg-5

VWF CRIM1 TIE1 APOLD1 DLL4 JAG1 LTBP2

1.32e-04456537GSM777032_500
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_reference_PulmonMicrovasc_top-relative-expression-ranked_1000

SNED1 RELN VWF CRIM1 TIE1 APOLD1 DLL4 STK32B LTBP2 GALNT6

1.35e-049815310PCBC_ctl_PulmonMicrovasc_1000
CoexpressionAtlasMesoderm Day 30_vs_Mesoderm Day 15-Confounder_removed-fold2.0_adjp0.05

FBN1 LTBP2 STAT3

1.36e-0440533PCBC_ratio_MESO-30_vs_MESO-15_cfr-2X-p05
CoexpressionAtlasStromal Cells, BEC.SLN, gp38- CD31+, Lymph Node, avg-4

VWF CRIM1 TIE1 APOLD1 DLL4 JAG1 LTBP2

1.38e-04459537GSM777037_500
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_EmbryoidBody_fromBlastocyst-derived-humanEmbryonicStemCells_top-relative-expression-ranked_1000

ADAMTS19 RELN SCUBE1 DLL4 WNT7A WNT8B SCUBE3 SHISA2 LRP1B FBN3

1.48e-049925310PCBC_EB_blastocyst_1000
CoexpressionAtlasDevelopingKidney_e15.5_Endothelial cells_emap-29977_k-means-cluster#3_top-relative-expression-ranked_100

STAB2 TIE1 APOLD1

2.07e-0446533DevelopingKidney_e15.5_Endothelial cells_emap-29977_k3_100
CoexpressionAtlasJC_hmvEC_top-relative-expression-ranked_500_k-means-cluster#1

RELN VWF TIE1 DLL4 LTBP2

2.14e-04219535JC_hmvEC_500_K1
CoexpressionAtlasDevelopingKidney_e11.5_metaneph mesench_emap-3843_k-means-cluster#1_top-relative-expression-ranked_200

APOLD1 ADAM23 LRP8

2.81e-0451533gudmap_developingKidney_e11.5_metaneph mesench_200_k1
CoexpressionAtlasthyroid gland

SCUBE3 SHISA2 LRP1B FBN3 LRP8

3.26e-04240535thyroid gland
CoexpressionAtlasDevelopingKidney_e15.5_Cap mesenchyme_emap-27738_k-means-cluster#3_top-relative-expression-ranked_500

SCUBE3 LRP4 LTBP1

3.91e-0457533gudmap_developingKidney_e15.5_Cap mesenchyme_500_k3
CoexpressionAtlaskidney_P4_CapMesRenVes_Crym_k-means-cluster#3_top-relative-expression-ranked_200

JAG1 SCUBE3 LRP4

5.00e-0462533gudmap_kidney_P4_CapMesRenVes_Crym_k3_200
CoexpressionAtlaskidney_P3_CapMes_Crym_k-means-cluster#2_top-relative-expression-ranked_500

JAG1 SCUBE3 LRP4 LTBP1

5.09e-04148534gudmap_kidney_P3_CapMes_Crym_k2_500
CoexpressionAtlasDevelopingKidney_e12.5_renal vesicle_emap-27679_top-relative-expression-ranked_500

JAG1 WNT8B SCUBE3 LRP4 LTBP1 LRP8

5.40e-04411536gudmap_developingKidney_e12.5_renal vesicle_500
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_reference_CardiacMyocyte_top-relative-expression-ranked_1000

SNED1 RELN FBN1 CRIM1 APOLD1 ADAM9 SCUBE3 LTBP2 ITGB1

6.27e-04975539PCBC_ctl_CardiacMyocyte_1000
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_reference_CardioEndothel_top-relative-expression-ranked_1000

SNED1 VWF CRIM1 TIE1 APOLD1 DLL4 STK32B LTBP2 GALNT6

6.41e-04978539PCBC_ctl_CardioEndothel_1000
CoexpressionAtlasratio_induced-Ectoderm_vs_StemCell_top-relative-expression-ranked_1000

RELN SCUBE1 FBN1 VWF SCUBE2 APOLD1 WNT8B SCUBE3 LTBP2

6.80e-04986539PCBC_ratio_ECTO_vs_SC_1000
CoexpressionAtlasDevelopingKidney_e11.5_metaneph mesench_emap-3843_top-relative-expression-ranked_500

VWF APOLD1 ADAM23 SCUBE3 ASTN1 LRP8

6.92e-04431536gudmap_developingKidney_e11.5_metaneph mesench_500
CoexpressionAtlasDevelopingKidney_e13.5_podocyte cells_emap-27773_top-relative-expression-ranked_500

SNED1 STAB2 WNT8B SCUBE3 ASTN1 LRP8

6.92e-04431536gudmap_developingKidney_e13.5_podocyte cells_500
CoexpressionAtlasDevelopingKidney_e12.5_renal vesicle_emap-27679_top-relative-expression-ranked_200

JAG1 SCUBE3 LTBP1 LRP8

6.98e-04161534gudmap_developingKidney_e12.5_renal vesicle_200
CoexpressionAtlasJC_hmvEC_top-relative-expression-ranked_1000

SNED1 RELN VWF CRIM1 TIE1 DLL4 LTBP2 LTF GALNT6

7.00e-04990539JC_hmvEC_1000
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_induced-Ectoderm_from_inducedPluripotentialStemCells_derived from_from_fibroblast_top-relative-expression-ranked_1000

ADAMTS19 SCUBE1 SCUBE2 WNT8B SCUBE3 ASTN1 SHISA2 MUC3A FBN3

7.05e-04991539PCBC_ECTO_fibroblast_1000
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_EmbryoidBody_top-relative-expression-ranked_1000

ADAMTS19 RELN SCUBE1 DLL4 WNT7A WNT8B SCUBE3 LRP1B FBN3

7.20e-04994539PCBC_EB_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#2

RELN SCUBE1 CRIM1 SCUBE3 HERC2 NOTCH2

7.44e-04437536Facebase_RNAseq_e10.5_Lateral Nasal Eminence_2500_K2
CoexpressionAtlaskidney_P4_CapMesRenVes_Crym_k-means-cluster#3_top-relative-expression-ranked_500

JAG1 SCUBE3 LRP4 PDZD2

7.65e-04165534gudmap_kidney_P4_CapMesRenVes_Crym_k3_500
CoexpressionAtlaskidney_P0_JuxtaGlom_Ren1_k-means-cluster#3_top-relative-expression-ranked_1000

RELN JAG1 SCUBE3 LTBP1 NOTCH2

8.07e-04293535gudmap_kidney_P0_JuxtaGlom_Ren1_k3_1000
CoexpressionAtlasgudmap_RNAseq_e15.5_Podocytes_2500_K3

SCUBE2 SCUBE3 SHISA2

9.08e-0476533gudmap_RNAseq_e15.5_Podocytes_2500_K3
CoexpressionAtlaskidney_P0_JuxtaGlom_Ren1_top-relative-expression-ranked_500

VLDLR RELN FBN1 CRIM1 JAG1 NOTCH2

9.28e-04456536gudmap_kidney_P0_JuxtaGlom_Ren1_500
CoexpressionAtlasDevelopingKidney_e15.5_Endothelial cells_emap-29977_k-means-cluster#3_top-relative-expression-ranked_200

STAB2 TIE1 APOLD1

1.02e-0379533DevelopingKidney_e15.5_Endothelial cells_emap-29977_k3_200
CoexpressionAtlasStem Cells, SC.LT34F.BM, Lineage- cKit+ Sca-1+ flk2- CD34-, Bone marrow, avg-3

VLDLR TIE1 SUSD1

1.05e-0380533GSM791102_100
CoexpressionAtlasDevelopingKidney_e11.5_metaneph mesench_emap-3843_top-relative-expression-ranked_1000

SNED1 VWF APOLD1 ADAM23 SCUBE3 ASTN1 TUT1 LRP8

1.14e-03850538gudmap_developingKidney_e11.5_metaneph mesench_1000
CoexpressionAtlasStem Cells, SC.LTSL.BM, CD117+ IL7R- CD150+ CD48- AA4.1+ CD43+, Bone marrow, avg-1

TIE1 SUSD1 LTF

1.17e-0383533GSM476663_100
CoexpressionAtlasDevelopingKidney_e15.5_Endothelial cells_emap-29977_top-relative-expression-ranked_100

STAB2 TIE1 APOLD1

1.21e-0384533DevelopingKidney_e15.5_Endothelial cells_emap-29977_100
CoexpressionAtlasDevelopingKidney_e15.5_Endothelial cells_emap-29965_k-means-cluster#4_top-relative-expression-ranked_200

STAB2 TIE1 APOLD1

1.30e-0386533gudmap_developingKidney_e15.5_Endothelial cells_200_k4
CoexpressionAtlasJC_iEC_top-relative-expression-ranked_2500_k-means-cluster#1

VLDLR RELN SCUBE2 TIE1 STK32B LRP4 EGFEM1P

1.34e-03672537JC_iEC_2500_K1
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_inducedDefinitiveEndoderm_fromFibroblast-derived-iPSC_top-relative-expression-ranked_500

ADAMTS19 VWF WNT8B SHISA2 MUC3A FBN3

1.37e-03492536PCBC_DE_fibroblast_500
CoexpressionAtlasStem Cells, SC.ST34F.BM, Lineage- cKit+ Sca-1+ flk2- CD34+, Bone marrow, avg-2

VLDLR TIE1 SUSD1

1.58e-0392533GSM791112_100
ToppCelldroplet-Bladder-nan-24m-Endothelial|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN VWF COL19A1 TIE1 APOLD1 DLL4 LTBP1

3.48e-091965379a90dd26e7a43e3fd55e7c5d8354cfa4cdd5a6cc
ToppCelldroplet-Bladder-nan-24m-Endothelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN VWF COL19A1 TIE1 APOLD1 DLL4 LTBP1

3.48e-0919653704dfef1bd4ebb0e9469ae80024dc177e469a2560
ToppCellLPS_IL1RA-Endothelial-Endothelial-Artery|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

VLDLR FBN1 VWF TIE1 DLL4 JAG1 LTBP1

4.00e-09200537ac9ead34afa14067171833f5c277eaf06db7b02e
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / Treatment groups by lineage, cell group, cell type

VLDLR FBN1 VWF TIE1 DLL4 JAG1 LTBP1

4.00e-09200537b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCellControl_saline-Endothelial-Endothelial-Vein|Control_saline / Treatment groups by lineage, cell group, cell type

FBN1 VWF TIE1 JAG1 LTBP1 LTF LRP1B

4.00e-09200537e5f876910bc8cb390d9b46a48d9b6d4d57235551
ToppCellEndothelial-B-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

RELN STAB2 FBN1 TIE1 APOLD1 DLL4

5.46e-0817153607ff7059071da83da1d8f266a586573920d75b58
ToppCellE15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

VWF TIE1 APOLD1 JAG1 ITGB1 PDZD2

5.46e-081715363112d15f2a28cf4a71992db4971d960716dc1264
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel|Adult / Lineage, Cell type, age group and donor

VWF TIE1 DLL4 ADAM23 STK32B LRP1B

5.66e-08172536ad4ffdb3fc0c560a9cbaa2bc048476cbc43e8fd6
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel-D175|Adult / Lineage, Cell type, age group and donor

VWF TIE1 APOLD1 DLL4 STK32B LRP1B

6.71e-08177536c9f269765c7d5d29caab75910e51645606ed562e
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN STAB2 VWF TIE1 APOLD1 FBN3

6.71e-08177536b1775e05c28883a15c56628028770bc59d3233fb
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF CRIM1 TIE1 DLL4 JAG1 IL17F

7.65e-081815364d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCellEndothelial-B-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

RELN STAB2 TIE1 ADAM23 STK32B LTF

7.65e-081815364fe0215d08f03d4e24749d70fce01b7aa22906fd
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF CRIM1 TIE1 DLL4 JAG1 IL17F

8.17e-081835363427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCellEndothelial-E|World / shred on cell class and cell subclass (v4)

VWF CRIM1 TIE1 JAG1 LTBP1 ITGB1

8.44e-08184536b4c561924c508536fd2112e91e32176b95fdf63a
ToppCellCOVID-19-Endothelial_cells-Arterial_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

VWF CRIM1 TIE1 DLL4 LTBP1 PDZD2

8.44e-081845360f19494789f38ab1a420545e15e748ca7eb345c3
ToppCelldroplet-Bladder-nan-24m-Endothelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN VWF COL19A1 TIE1 APOLD1 DLL4

8.71e-0818553690caab8d9361a541c5d5121c97c3f1cdffeeae4a
ToppCellControl-Endothelial-Endothelial-Artery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF TIE1 DLL4 JAG1 LTBP1 LRP1B

8.99e-081865362d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCelldroplet-Lung-3m-Endothelial-arterial_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF TIE1 APOLD1 DLL4 JAG1 STK32B

8.99e-08186536b80aaeebc03a318052076d2f02c123f5ddc5e73a
ToppCelldroplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF TIE1 APOLD1 DLL4 JAG1 STK32B

8.99e-081865368a8ed1502542d4895cba3fd5d534256206578716
ToppCellControl-Endothelial-Endothelial-Vein|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

VWF TIE1 LTBP1 LTF LRP1B LRP8

8.99e-0818653692092f11ecce22c14f244e42c499af0822977e6f
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Artery|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 VWF TIE1 DLL4 JAG1 LTBP1

9.89e-08189536c45734970036e6d28d5e3fe7c9458fae38a3f624
ToppCellLPS-IL1RA-Endothelial-Endothelial-Artery|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 VWF TIE1 DLL4 JAG1 LTBP1

1.02e-07190536aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal|E16.5-samps / Age Group, Lineage, Cell class and subclass

VLDLR FBN1 SCUBE2 LRP4 SHISA2 NOTCH2

1.05e-071915363379d145d34f89150f7b06d1340022cfc6b4a6ce
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FBN1 VWF TIE1 DLL4 JAG1 LTBP1

1.05e-071915364b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 TIE1 APOLD1 DLL4 JAG1 LTBP1

1.05e-07191536b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 CRIM1 TIE1 APOLD1 DLL4 ADAM23

1.09e-071925362bfac6b3956265205ca47d06888851ed68b65999
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 CRIM1 TIE1 APOLD1 DLL4 ADAM23

1.09e-07192536d525f7f088a53110912600a7c9f6d33b9270d534
ToppCellfacs-MAT-Fat-24m-Endothelial-nan|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF CRIM1 TIE1 APOLD1 DLL4 JAG1

1.12e-07193536ba9a47e2dc01efa6d2a99b1631d4951fac2648d4
ToppCellfacs-MAT-Fat-24m-Endothelial-endothelial_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF CRIM1 TIE1 APOLD1 DLL4 JAG1

1.12e-07193536724bb613fa434add5b1c5586b629328f819fbdfe
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SNED1 FBN1 TIE1 DLL4 JAG1 LTBP1

1.12e-071935362e72309607902dabe3218888b22a77fe941f3570
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF CRIM1 TIE1 JAG1 LTBP1 ITGB1

1.12e-0719353658c590dd6f21bc7ae58ae1729dd574c0f1069592
ToppCellfacs-MAT-Fat-24m-Endothelial|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF CRIM1 TIE1 APOLD1 DLL4 JAG1

1.12e-07193536737e540c72a3cfe8dbd4c0f139f7d729a166793a
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 CRIM1 TIE1 APOLD1 DLL4 ADAM23

1.15e-07194536c8b9551b93a5aed62154b487db90130604a6125c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF CRIM1 TIE1 APOLD1 DLL4 ITGB1

1.15e-07194536ea5e1bc8d9e27cabfe1fb833ca47ec0893593b12
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF CRIM1 TIE1 APOLD1 DLL4 ITGB1

1.15e-07194536cceb7c88492bb6cd531e1c2651638da1ddf30931
ToppCellCOVID-19-kidney-PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

SNED1 SCUBE1 VWF TIE1 APOLD1 DLL4

1.19e-07195536a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FBN1 MUC19 LRP4 LTF MUC3A LRP1B

1.19e-07195536d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

FBN1 MUC19 LRP4 LTF MUC3A LRP1B

1.19e-0719553619853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCellfacs-Lung-nan-3m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SNED1 RELN TIE1 APOLD1 DLL4 ITGB1

1.19e-071955367f9b7f15006610ad591063d90e90367bd6083c7f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SNED1 FBN1 VWF TIE1 DLL4 JAG1

1.19e-0719553677e47d2e8b3eb7f7c9620369ccaf87581f923bdb
ToppCellTracheal-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RELN STAB2 VWF TIE1 DLL4 STK32B

1.23e-0719653609a7edf4a7defb7fe70d9777dd9500ee8421ff31
ToppCellTracheal-NucSeq-Endothelial-Endothelia_lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RELN STAB2 VWF TIE1 DLL4 STK32B

1.23e-07196536e50d2c66d5c5cd25fdfecdcc4c8506a1d0a85755
ToppCellproximal-Endothelial-Lymphatic|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RELN STAB2 TIE1 APOLD1 DLL4 STK32B

1.26e-071975368835961bd734a86063fd854cd2fb7028aefb7a72
ToppCellproximal-Endothelial-Lymphatic-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RELN STAB2 TIE1 APOLD1 DLL4 STK32B

1.26e-071975368d79e747e344656e2bfc7fe872b4430dca941196
ToppCellproximal-3-Endothelial-Lymphatic|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RELN STAB2 TIE1 APOLD1 DLL4 STK32B

1.26e-071975361c64e4eb9bfbaf5d6b4349642858f83a00d4d4c6
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF CRIM1 TIE1 APOLD1 DLL4 ITGB1

1.26e-071975369244f087ba4b60fdc81d54ce91860de715b3e12c
ToppCelldroplet-Bladder-nan-24m-Endothelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RELN VWF TIE1 APOLD1 DLL4 LTBP1

1.26e-07197536488e85991c5e668afb7672942726d9295b8fc7d8
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF CRIM1 TIE1 APOLD1 DLL4 ITGB1

1.30e-07198536218f33e068eb126458ec33176de3cfa6fc06ddf0
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

VWF CRIM1 TIE1 APOLD1 DLL4 ITGB1

1.30e-071985367cddd474416651088a4e08edfc0ac420ff10a5fe
ToppCellParenchyma_COVID-19-Endothelial-TX-Lymphatic|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

RELN STAB2 CRIM1 TIE1 APOLD1 STK32B

1.34e-0719953688f33b8dcd837abfa1d12c28719e073a7da6e979
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RELN STAB2 CRIM1 TIE1 APOLD1 STK32B

1.34e-0719953664b19aff72e2a109cb5857cb248bd4712dd49b43
ToppCellLung_Parenchyma-Severe-Endothelial-Endothelial-Lymphatic-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RELN STAB2 CRIM1 TIE1 APOLD1 STK32B

1.34e-071995362b9e1e069b36b3a61cc3e384f4523687b0e03905
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Artery|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FBN1 VWF TIE1 DLL4 JAG1 LTBP1

1.38e-0720053677ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCellControl_saline-Endothelial-Endothelial-Artery|Control_saline / Treatment groups by lineage, cell group, cell type

FBN1 VWF TIE1 DLL4 JAG1 LTBP1

1.38e-0720053665b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Artery|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FBN1 VWF TIE1 DLL4 JAG1 LTBP1

1.38e-07200536b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCellEndothelial-G|World / shred on cell class and cell subclass (v4)

SNED1 RELN STAB2 TIE1 APOLD1

3.78e-071245354b72809463f2986b7d1b7ab9de633ac4d7854a92
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS19 MUC19 ASTN1 TECTA LRP1B

1.34e-06160535c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS19 MUC19 ASTN1 TECTA LRP1B

1.34e-0616053525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellfacs-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FCGBP MUC19 LRP4 LTF GALNT6

1.38e-06161535b9a17f41426bf715f30bf544a6795afaf37a3aa6
ToppCellfacs-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FCGBP MUC19 LRP4 LTF GALNT6

1.38e-06161535f7a89c481f789f624102857be722c95fbeb47595
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

VWF TIE1 DLL4 JAG1 MUC19

1.42e-0616253525bb1b9709f960fdf90faff56e874f52a8f5d17e
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RELN STAB2 TIE1 APOLD1 ASTN1

1.55e-06165535347b59aa625a8a960828b8620824d8ac48990e07
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RELN STAB2 TIE1 APOLD1 ASTN1

1.55e-06165535507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RELN STAB2 TIE1 APOLD1 ASTN1

1.55e-0616553539a25be081a5d59c7cf107a997d352793d5025fb
ToppCellPND03-Endothelial-Endothelial_lymphatic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RELN STAB2 TIE1 APOLD1 ASTN1

1.55e-061655351890f9c33b0c5b381d57f97042da2610a093a6de
ToppCellCOVID-19-kidney-Lymphatic_EC|kidney / Disease (COVID-19 only), tissue and cell type

RELN STAB2 FBN1 TIE1 DLL4

1.65e-0616753597d0fea1f41c1c00e36d9b5c4c1f0dd85087056f
ToppCellEndothelial-B-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

RELN STAB2 VWF TIE1 APOLD1

1.75e-061695358889c9e8af1ab0b093d57b69abd80b59b3461be9
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF TIE1 JAG1 ASTN1 SHISA2

1.80e-0617053550c6c571591aa4b218caefe5778c570c809f567e
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF TIE1 JAG1 ASTN1 SHISA2

1.80e-061705358fe32dcf924d5f6665f7febbc9647d96b1e96f06
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF TIE1 JAG1 ASTN1 SHISA2

1.80e-061705353232db50b1a40f861e981a1b9c9073b81af9f832
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-arterial_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

VWF TIE1 DLL4 JAG1 MUC19

1.96e-061735353a9e9a09b3eeb37cbe56d650e112a8398879477f
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF TIE1 JAG1 LTBP1 ITGB1

2.07e-061755352e54961846c65b185d9bd6e305dd81205579d890
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF TIE1 JAG1 LTBP1 ITGB1

2.07e-06175535efa6a05f7417d46141b6e635f258c126b7a03aa1
ToppCell(0)_Normal/No_Treatment-(3)_LEPR+_perivascular_cells|World / Stress and Cell class

SNED1 FBN1 LRP4 LTBP1 ITGB1

2.13e-06176535ce2c32b5ce0da848eb4da35ce4d215cdf74d9113
ToppCellControl-Neuronal_cells-Neuronal_cells|Control / group, cell type (main and fine annotations)

RELN STAB2 TIE1 APOLD1 STK32B

2.13e-0617653598c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCellControl-Neuronal_cells|Control / group, cell type (main and fine annotations)

RELN STAB2 TIE1 APOLD1 STK32B

2.13e-06176535c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 VWF TIE1 DLL4 JAG1

2.13e-0617653527e6b3ae41068d6cfdda3d46da7df2a27567140e
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FBN1 VWF TIE1 DLL4 JAG1

2.13e-06176535d6a5470af9592f34a741265f2ea9651c05c3add3
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

VWF TIE1 DLL4 JAG1 MUC19

2.19e-061775355ff8dcfb030312126695d53a026d2e104a401b83
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RELN STK32B LTF FBN3 EGFEM1P

2.32e-06179535cd7f0e8f4abb2a2bac366c8910c8c5fda841dbce
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

VWF TIE1 DLL4 JAG1 PDZD2

2.32e-061795352a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCellfacs-Lung-24m-Endothelial-venous_endothelial-vein_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF CRIM1 TIE1 APOLD1 JAG1

2.38e-06180535178648429686e6d4e6f3aafc350130e819788ecf
ToppCellfacs-Lung-24m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF CRIM1 TIE1 APOLD1 JAG1

2.38e-06180535fcd5d5bf00ee728162b0aac4c81eb78e742cf6f2
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SCUBE1 VWF TIE1 STK32B ITGB1

2.38e-0618053540d4838a0ccb10d5e49266bc8a0037d27b75ccc2
ToppCellfacs-Lung-24m-Endothelial-venous_endothelial|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWF CRIM1 TIE1 APOLD1 JAG1

2.38e-06180535c2a8f61c806f6f6f47743e9f7c9700705db43386
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SNED1 COL19A1 MUC19 LRP1B PDZD2

2.45e-061815359de2f2cc5f02e0ca599c9e0d2cb1e1e4b5aac112
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SCUBE1 FBN1 LRP4 LTBP1 LTBP2

2.45e-06181535b116c68393d8836bac080f81a8fcbeb52e0403e7
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 VWF TIE1 APOLD1 DLL4

2.45e-061815352e15c46e8260bb04d8264478c19a707221996026
ToppCellCOVID-19-Heart-EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

VWF APOLD1 JAG1 MUC3A PDZD2

2.51e-06182535e67f3234165199085c793915ebb1f9bbd845e933
ToppCell5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN STAB2 VWF TIE1 APOLD1

2.51e-06182535fd786c88826ad3d5cc5c3d80f8e392d6be1b5267
ToppCelldroplet-Kidney-nan-3m-Endothelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIE1 APOLD1 DLL4 ASTN1 LTBP1

2.51e-06182535f4a5f1c3a04c0566eb96607dab7a0d9a5ebc3fd1
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RELN STAB2 TIE1 APOLD1 STK32B

2.58e-061835354d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCellP03-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RELN STAB2 TIE1 APOLD1 ASTN1

2.58e-0618353589727b4f65949ed2dce9d2e0228c79fe4280230c
ToppCellP03-Endothelial-lymphatic_endothelial_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RELN STAB2 TIE1 APOLD1 ASTN1

2.58e-06183535113e6d8d4bb271be984af06cd6c22b180425dcfc
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF CRIM1 TIE1 APOLD1 JAG1

2.58e-06183535fc9a7ba148c22d0c8a46f6bc56c772929ac496f7
ToppCell5'-Adult-Appendix-Endothelial-lymphatic_endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RELN STAB2 VWF TIE1 APOLD1

2.65e-06184535453295362888c9a59d0e73c7a5b15914c50ff591
ToppCellmetastatic_Brain-Endothelial_cells-Stalk-like_ECs|metastatic_Brain / Location, Cell class and cell subclass

VWF CRIM1 TIE1 APOLD1 DLL4

2.72e-06185535ad52970e88e8947ef256095bd4b40229b912d58a
ToppCelldroplet-Lung-nan-3m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF TIE1 DLL4 JAG1 STK32B

2.72e-06185535eeb6f55a6f79adf80247baa2c4b0df44553557ad
ToppCelldroplet-Fat-Mat-18m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF COL19A1 CRIM1 TIE1 APOLD1

2.72e-06185535d9be5853acdda7b1ac819cf50c7940d1d2362d15
ToppCelldroplet-Marrow-nan-18m-Hematologic-hematopoietic_precursor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VLDLR VWF TIE1 LTBP1 GALNT6

2.72e-06185535de353368f4f6a7a0a66e391d586879876fbe2734
ComputationalMetal / Ca ion binding.

FBN1 ADAM9 LTBP1 LTBP2 LTF LDLR

3.87e-06133356MODULE_324
ComputationalGenes in the cancer module 236.

VLDLR LDLR LRP8

2.50e-0518353MODULE_236
ComputationalECM and collagens.

FBN1 VWF TIE1 ADAM9 LTBP1 LTBP2

7.68e-05225356MODULE_47
ComputationalOvary genes.

FBN1 VWF CRIM1 LTBP1 LTBP2 LDLR STAT3

1.53e-04368357MODULE_1
DrugVerteporfin [129497-78-5]; Down 200; 2.8uM; MCF7; HT_HG-U133A

CRIM1 ADAM9 LTBP1 GALNT6 ITGB1 NOTCH2

2.22e-061615463556_DN
Drug12-tungstophosphate

HERC2 LDLR

5.52e-062542CID006398471
DrugAC1L1GUQ

DLL4 JAG1 LDLR NOTCH2

6.00e-0650544CID000003849
Drugnapabucasin

JAG1 ITGB1 NOTCH2 STAT3

1.62e-0564544ctd:C000621033
Drugtriple sulfa

MCPH1 JAG1

1.65e-053542CID000060896
DiseaseHepatic ductular hypoplasia

JAG1 NOTCH2

3.17e-062532C2930797
DiseaseAlagille syndrome (is_implicated_in)

JAG1 NOTCH2

3.17e-062532DOID:9245 (is_implicated_in)
DiseaseAlagille Syndrome 2

JAG1 NOTCH2

3.17e-062532C1857761
DiseaseAlagille Syndrome

JAG1 NOTCH2

3.17e-062532C0085280
DiseaseArteriohepatic dysplasia

JAG1 NOTCH2

3.17e-062532cv:C0085280
DiseaseAlagille Syndrome 1

JAG1 NOTCH2

3.17e-062532C1956125
Diseaseintraocular pressure measurement

RELN FBN1 ADSS2 MCPH1 LRP4 LTBP1 LTBP2 HERC2

3.33e-06509538EFO_0004695
Diseaseglomerulonephritis (biomarker_via_orthology)

FBN1 LTBP1 ITGB1

6.10e-0620533DOID:2921 (biomarker_via_orthology)
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN3

9.49e-063532DOID:65 (implicated_via_orthology)
DiseaseWeill-Marchesani syndrome

FBN1 LTBP2

9.49e-063532C0265313
DiseaseWeill-Marchesani Syndrome, Autosomal Dominant

FBN1 LTBP2

9.49e-063532C1869115
DiseaseWeill-Marchesani Syndrome, Autosomal Recessive

FBN1 LTBP2

9.49e-063532C1869114
Diseasesevere acute respiratory syndrome, COVID-19

RELN SCUBE1 ADSS2 ADAM23 LTBP2 LRP1B PDZD2

1.48e-05447537EFO_0000694, MONDO_0100096
DiseaseWeill-Marchesani syndrome

FBN1 LTBP2

1.89e-054532cv:C0265313
DiseaseWeill-Marchesani syndrome (is_implicated_in)

FBN1 LTBP2

1.89e-054532DOID:0050475 (is_implicated_in)
Diseasecentral corneal thickness

ADAMTS19 FBN1 CRIM1 LTBP1 GALNT6 HERC2

1.91e-05309536EFO_0005213
Diseasecortical surface area measurement

ADAMTS19 RELN SCUBE1 FBN1 MCPH1 BAZ2B WNT7A JAG1 FBN3 LRP8 PDZD2

2.21e-0513455311EFO_0010736
Diseasecortical thickness

RELN SCUBE1 FBN1 CRIM1 MCPH1 WNT7A JAG1 LRP4 LRP8 PDZD2

2.49e-0511135310EFO_0004840
Diseasefactor VIII measurement, venous thromboembolism

STAB2 VWF LRP4

3.15e-0534533EFO_0004286, EFO_0004630
Diseasemesangial proliferative glomerulonephritis (biomarker_via_orthology)

FBN1 VWF

8.80e-058532DOID:4783 (biomarker_via_orthology)
Diseasemicrocephaly (is_implicated_in)

MCPH1 NSD1

8.80e-058532DOID:10907 (is_implicated_in)
DiseaseAlzheimer's disease (is_implicated_in)

VLDLR LDLR STAT3 LRP8

9.45e-05132534DOID:10652 (is_implicated_in)
DiseaseGastrointestinal Hemorrhage

RELN LTF

1.13e-049532C0017181
DiseaseMalignant neoplasm of breast

ADAMTS19 VWF COL19A1 DLL4 JAG1 HERC2 TECTA NOTCH2 STAT3

1.14e-041074539C0006142
Diseaseglaucoma

LTBP1 LTBP2 HERC2 LRP1B

1.71e-04154534MONDO_0005041
DiseaseMarfan Syndrome

FBN1 LTBP2

1.72e-0411532C0024796
DiseaseUlcerative Colitis

LTF HERC2 STAT3

2.01e-0463533C0009324
Diseasedementia (is_implicated_in)

VLDLR LRP8

2.07e-0412532DOID:1307 (is_implicated_in)
Diseaseautistic disorder (is_marker_for)

VLDLR RELN

2.07e-0412532DOID:12849 (is_marker_for)
DiseaseFEV/FEC ratio

FBN1 FCGBP CRIM1 WNT7A NSD1 SCUBE3 LTBP1 TUT1 LTBP2

3.09e-041228539EFO_0004713
DiseaseProteinuria

VWF STK32B

3.27e-0415532HP_0000093
Diseasedilated cardiomyopathy (implicated_via_orthology)

DLL4 JAG1 LTBP2

4.08e-0480533DOID:12930 (implicated_via_orthology)
Diseasefactor VIII measurement, Ischemic stroke

STAB2 VWF

5.31e-0419532EFO_0004630, HP_0002140
Diseasebipolar disorder (is_marker_for)

RELN VWF

5.31e-0419532DOID:3312 (is_marker_for)
Diseasecortisol measurement

LDLR EGFEM1P

5.89e-0420532EFO_0005843
Diseasebirth weight

VLDLR MCPH1 APOLD1 BAZ2B JAG1

7.42e-04399535EFO_0004344
Diseasevenous thromboembolism, tissue plasminogen activator measurement

VWF LRP4

7.82e-0423532EFO_0004286, EFO_0004791
Diseaseinflammatory bowel disease (implicated_via_orthology)

STAT3 PDZD2

9.25e-0425532DOID:0050589 (implicated_via_orthology)
Diseasecorpus collosum mid-posterior volume measurement

VLDLR JAG1

9.25e-0425532EFO_0010300
Diseaseresponse to gemcitabine

MCPH1 IL17F

9.25e-0425532GO_0036272
Diseasebody surface area

FBN1 CRIM1 MCPH1 NSD1 LTBP1 LTBP2

1.01e-03643536EFO_0022196
DiseaseRS-10-hydroxywarfarin to RS-warfarin ratio measurement

MUC3B MUC3A FBN3

1.03e-03110533EFO_0803335
Diseasefactor VIII measurement, von Willebrand factor measurement

STAB2 VWF

1.08e-0327532EFO_0004629, EFO_0004630
Diseasecorpus callosum central volume measurement

JAG1 PDZD2

1.16e-0328532EFO_0010296
Diseasecorneal resistance factor

ADAMTS19 FBN1 LTBP1 GALNT6 HERC2

1.28e-03451535EFO_0010067
Diseasecolorectal cancer (implicated_via_orthology)

NOTCH2 STAT3

1.33e-0330532DOID:9256 (implicated_via_orthology)
Diseasefactor XI measurement, venous thromboembolism

VWF LRP4

1.33e-0330532EFO_0004286, EFO_0004694
DiseaseIschemic stroke, von Willebrand factor measurement

STAB2 VWF

1.33e-0330532EFO_0004629, HP_0002140
DiseaseSquamous cell carcinoma

ITGB1 NOTCH2 STAT3

1.46e-03124533C0007137
Diseasevital capacity

ADAMTS19 CRIM1 WNT7A LTBP1 LTBP2 PCGF5 FBN3 PDZD2

1.54e-031236538EFO_0004312
Diseaserenal cell carcinoma (is_marker_for)

VWF DLL4 STAT3

1.59e-03128533DOID:4450 (is_marker_for)
Diseasedisease recurrence, unipolar depression, bipolar disorder, schizophrenia, sex interaction measurement

ADAMTS19 LRP1B

1.61e-0333532EFO_0003761, EFO_0004952, EFO_0008343, MONDO_0004985, MONDO_0005090
Diseasecervical cancer

NOTCH2 STAT3

1.71e-0334532C4048328

Protein segments in the cluster

PeptideGeneStartEntry
ACNQNQGRCYNGECK

ADAM23

591

O75077
GGGNRKCNQEQSKNQ

BAZ2B

206

Q9UIF8
CFNGGSCRERNQGAN

DLL4

371

Q9NR61
VDCGLDKSNCGKQQN

DLL4

596

Q9NR61
QGCVDINECRVQNGG

FBN3

1151

Q75N90
SDGFNGGCEQLCLQQ

ASTN1

661

O14525
CQLACGQDGQLKGFA

RAVER1

251

Q8IY67
GGGAALKENVCQNCE

NSD1

1536

Q96L73
QGLDICANGRCQKVG

ADAMTS19

751

Q8TE59
CKNGVNGTGENGRKC

ITGB1

401

P05556
QGCGDRQLLQCGRNA

APOLD1

176

Q96LR9
NHRCQNGGVCVDGVN

NOTCH2

266

Q04721
ICLDCLRNNGQSGDN

PCGF5

141

Q86SE9
KQQGDNMCRVNNGGC

LRP1B

791

Q9NZR2
DDLCGNSGCGNQERK

MCPH1

236

Q8NEM0
RLNGQGVCQIECGAQ

HERC2

3201

O95714
DECQQGNLCVNGQCK

LTBP1

1081

Q14766
GNLCVNGQCKNTEGS

LTBP1

1086

Q14766
QAEECGILNGCENGR

LTBP1

1621

Q14766
KVCGLCGNNNGDLKD

MUC19

1406

Q7Z5P9
SGDRCQLQTRCQNGG

MUC3A

2976

Q02505
ESDRRGGCLAQGNCQ

PDZD2

2111

O15018
GGCLAQGNCQEKSEI

PDZD2

2116

O15018
QCRNLGCINAQGKED

IL17F

101

Q96PD4
QCEEMCNGQGSCING

RELN

2131

P78509
RIGNGQCKNQCHENE

DEFB110

36

Q30KQ9
GDIGALLKNFCGNCQ

COL19A1

686

Q14993
VCGLCGNMDRNPNND

FCGBP

1811

Q9Y6R7
AVCGLCGNMDRNPNN

FCGBP

3011

Q9Y6R7
QNGRICNNGRCINTD

FBN1

536

P35555
VDECASGNGNLCRNG

FBN1

1931

P35555
SGNGNLCRNGQCINT

FBN1

1936

P35555
TNQCLDVGENNRGGK

GALNT6

506

Q8NCL4
NENLIAGCNIINGKC

CRIM1

126

Q9NZV1
GNALCGKLQCENVQE

ADAM9

566

Q13443
GLQAEECGILNGCEN

LTBP2

1731

Q14767
NGGQCNKKTGNCDCT

EGFEM1P

116

Q0D2K5
CQDNNGGCQQICVNA

SCUBE1

121

Q8IWY4
QGACGAGQVLQDSKC

SCUBE1

616

Q8IWY4
GNELNGGCVHDCLNI

SCUBE2

91

Q9NQ36
VAQCKNRQCGGELGE

SCUBE3

796

Q8IX30
AGCLQGLNECLHNNG

LRP8

331

Q14114
NGELQNGNCCGGARN

JAG1

46

P78504
GQCQNDASCRDLVNG

JAG1

456

P78504
GDRCQLQTRCQNGGQ

MUC3B

891

Q9H195
NLCALCIGDEQGENK

LTF

521

P02788
ARLDQGGCDNDRQQG

SHISA2

81

Q6UWI4
AQDADIVCRCQGGNN

ADSS2

51

P30520
KECQHGGQCQVENGS

SNED1

356

Q8TER0
NGECGDLLKACNNDS

TECTA

886

O75443
NKVCGLCGNFNGDLT

TECTA

1616

O75443
NCGCDDSRNGQLGGQ

WNT8B

111

Q93098
HNGGQLCDRTQCGEA

ZNF778

111

Q96MU6
KVCGLCGNFDGIQNN

VWF

991

P04275
FGADCRLQCQCQNGG

TIE1

311

P35590
QKNCCEEGKEEQQGC

TUT1

666

Q9H6E5
QRCGNGGRANCDASL

STAT3

416

P40763
NGRTQCVDKNECQFG

SUSD1

66

Q6UWL2
NAQNVCFGNGICLDG

STAB2

1351

Q8WWQ8
GNLSDCGCDKEKQGQ

WNT7A

126

O00755
RGGGQAQSKLQDGCN

STK32B

386

Q9NY57
GSDEVNCKNVNQCLG

VLDLR

306

P98155
KECGTNECLDNNGGC

LDLR

311

P01130
GQRKLCNGVNDCGDN

LRP4

326

O75096
ENCNVNNGGCAQKCQ

LRP4

356

O75096
NNGGCAQKCQMVRGA

LRP4

361

O75096