Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cAMP-dependent protein kinase activity	PRKX PRKY	1.18e-04	7	48	2	GO:0004691
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1B CACNA1E NCS1	1.84e-04	46	48	3	GO:0005245
GeneOntologyMolecularFunction	cyclic nucleotide-dependent protein kinase activity	PRKX PRKY	2.02e-04	9	48	2	GO:0004690
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	CACNA1B CACNA1E	2.02e-04	9	48	2	GO:0099511
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	CACNA1B CACNA1E	2.02e-04	9	48	2	GO:0099626
GeneOntologyMolecularFunction	P-type sodium transporter activity	ATP1A1 ATP1A4	2.52e-04	10	48	2	GO:0008554
GeneOntologyMolecularFunction	P-type sodium:potassium-exchanging transporter activity	ATP1A1 ATP1A4	2.52e-04	10	48	2	GO:0005391
GeneOntologyMolecularFunction	P-type potassium transmembrane transporter activity	ATP1A1 ATP1A4	3.07e-04	11	48	2	GO:0008556
GeneOntologyMolecularFunction	calcium ion binding	CACNA1B PLA2G4A CACNA1E EPS15 OTOL1 OCM2 OCM NCS1	3.77e-04	749	48	8	GO:0005509
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1B CACNA1E	5.06e-04	14	48	2	GO:0008331
GeneOntologyMolecularFunction	K48-linked deubiquitinase activity	USP26 MINDY3	1.15e-03	21	48	2	GO:1990380
GeneOntologyMolecularFunction	protein serine kinase activity	PIK3R4 AATK ULK2 PRKX PRKY	1.74e-03	363	48	5	GO:0106310
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP26 USP10 MINDY3	2.60e-03	114	48	3	GO:0004843
GeneOntologyMolecularFunction	protein kinase activity	PIK3R4 AATK ULK2 PRKX PRKY PLK5	3.01e-03	600	48	6	GO:0004672
GeneOntologyMolecularFunction	deubiquitinase activity	USP26 USP10 MINDY3	3.30e-03	124	48	3	GO:0101005
GeneOntologyMolecularFunction	P-type transmembrane transporter activity	ATP1A1 ATP1A4	3.38e-03	36	48	2	GO:0140358
GeneOntologyMolecularFunction	P-type ion transporter activity	ATP1A1 ATP1A4	3.38e-03	36	48	2	GO:0015662
GeneOntologyMolecularFunction	calcium channel activity	CACNA1B CACNA1E NCS1	3.69e-03	129	48	3	GO:0005262
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	PIK3R4 AATK ULK2 PRKX PRKY	4.23e-03	446	48	5	GO:0004674
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP26 USP10 MINDY3	4.36e-03	137	48	3	GO:0019783
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA1B CACNA1E ATP1A1 ATP1A4 NCS1	5.04e-03	465	48	5	GO:0046873
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1B CACNA1E NCS1	5.72e-03	151	48	3	GO:0015085
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNA1B CACNA1E NCS1	5.82e-03	152	48	3	GO:0022843
GeneOntologyMolecularFunction	heme binding	CAT DGCR8 CYP11A1	6.04e-03	154	48	3	GO:0020037
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	PIK3R4 AATK GALT ULK2 PRKX PRKY PLK5	6.75e-03	938	48	7	GO:0016772
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	PIK3R4 AATK ULK2 PRKX PRKY PLK5	6.77e-03	709	48	6	GO:0016773
GeneOntologyMolecularFunction	tetrapyrrole binding	CAT DGCR8 CYP11A1	7.18e-03	164	48	3	GO:0046906
GeneOntologyCellularComponent	cilium	PIK3R4 USP26 CC2D2A EPS15 ATP1A1 ATP1A4 HYDIN CYRIB PCM1	1.77e-04	898	48	9	GO:0005929
GeneOntologyCellularComponent	sodium:potassium-exchanging ATPase complex	ATP1A1 ATP1A4	3.36e-04	12	48	2	GO:0005890
GeneOntologyCellularComponent	cuticular plate	OCM2 OCM	3.96e-04	13	48	2	GO:0032437
GeneOntologyCellularComponent	AP-2 adaptor complex	EPS15 STON2	4.62e-04	14	48	2	GO:0030122
GeneOntologyCellularComponent	clathrin coat of endocytic vesicle	EPS15 STON2	5.32e-04	15	48	2	GO:0030128
GeneOntologyCellularComponent	clathrin coat of coated pit	EPS15 STON2	1.05e-03	21	48	2	GO:0030132
Domain	EF_HAND_2	CACNA1B CACNA1E EPS15 OCM2 OCM NCS1	2.67e-05	231	48	6	PS50222
Domain	EF_hand_dom	CACNA1B CACNA1E EPS15 OCM2 OCM NCS1	2.73e-05	232	48	6	IPR002048
Domain	Parvalbumin	OCM2 OCM	6.44e-05	5	48	2	IPR008080
Domain	EF-hand-dom_pair	CACNA1B EPS15 MINDY3 OCM2 OCM NCS1	8.92e-05	287	48	6	IPR011992
Domain	P-type_ATPase_IIC	ATP1A1 ATP1A4	9.64e-05	6	48	2	IPR005775
Domain	VDCC_a1su_IQ	CACNA1B CACNA1E	1.35e-04	7	48	2	IPR014873
Domain	GPHH	CACNA1B CACNA1E	1.35e-04	7	48	2	PF16905
Domain	GPHH_dom	CACNA1B CACNA1E	1.35e-04	7	48	2	IPR031649
Domain	Ca_chan_IQ	CACNA1B CACNA1E	1.35e-04	7	48	2	SM01062
Domain	Ca_chan_IQ	CACNA1B CACNA1E	1.35e-04	7	48	2	PF08763
Domain	VDCCAlpha1	CACNA1B CACNA1E	2.87e-04	10	48	2	IPR002077
Domain	Kinase-like_dom	PIK3R4 KNDC1 AATK ULK2 PRKX PRKY PLK5	4.37e-04	542	48	7	IPR011009
Domain	-	EPS15 MINDY3 OCM2 OCM NCS1	5.38e-04	261	48	5	1.10.238.10
Domain	EFh	EPS15 OCM2 OCM NCS1	7.18e-04	158	48	4	SM00054
Domain	-	ATP1A1 ATP1A4	7.58e-04	16	48	2	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP1A1 ATP1A4	7.58e-04	16	48	2	IPR023298
Domain	ATPase_P-typ_cation-transptr_C	ATP1A1 ATP1A4	8.58e-04	17	48	2	IPR006068
Domain	Cation_ATPase_C	ATP1A1 ATP1A4	8.58e-04	17	48	2	PF00689
Domain	Cation_ATPase_N	ATP1A1 ATP1A4	9.64e-04	18	48	2	PF00690
Domain	Cation_ATPase_N	ATP1A1 ATP1A4	9.64e-04	18	48	2	SM00831
Domain	EF_Hand_1_Ca_BS	EPS15 OCM2 OCM NCS1	1.05e-03	175	48	4	IPR018247
Domain	ATPase_P-typ_cation-transptr_N	ATP1A1 ATP1A4	1.08e-03	19	48	2	IPR004014
Domain	EF-hand_7	OCM2 OCM NCS1	1.36e-03	85	48	3	PF13499
Domain	Prot_kinase_dom	PIK3R4 AATK ULK2 PRKX PRKY PLK5	1.51e-03	489	48	6	IPR000719
Domain	PROTEIN_KINASE_DOM	PIK3R4 AATK ULK2 PRKX PRKY PLK5	1.57e-03	493	48	6	PS50011
Domain	EF_HAND_1	EPS15 OCM2 OCM NCS1	1.85e-03	204	48	4	PS00018
Domain	-	ATP1A1 ATP1A4	3.05e-03	32	48	2	3.40.1110.10
Domain	-	ATP1A1 ATP1A4	3.05e-03	32	48	2	2.70.150.10
Domain	ATPase_P-typ_cyto_domN	ATP1A1 ATP1A4	3.65e-03	35	48	2	IPR023299
Domain	P_typ_ATPase	ATP1A1 ATP1A4	3.85e-03	36	48	2	IPR001757
Domain	ATPase_P-typ_P_site	ATP1A1 ATP1A4	3.85e-03	36	48	2	IPR018303
Domain	ATPASE_E1_E2	ATP1A1 ATP1A4	3.85e-03	36	48	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP1A1 ATP1A4	4.07e-03	37	48	2	IPR008250
Domain	E1-E2_ATPase	ATP1A1 ATP1A4	4.07e-03	37	48	2	PF00122
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	CACNA1B CACNA1E	4.04e-04	11	39	2	M47958
Pathway	WP_ARSENIC_METABOLISM_AND_REACTIVE_OXYGEN_SPECIES_GENERATION	CAT ATP1A1	4.04e-04	11	39	2	M45561
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNA1B CACNA1E	4.04e-04	11	39	2	MM14498
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNA1B CACNA1E	4.04e-04	11	39	2	M26913
Pubmed	Green fluorescence protein driven by the Na,K-ATPase α4 isoform promoter is expressed only in male germ cells of mouse testis.	ATP1A1 ATP1A4 DMRT1	4.92e-08	6	48	3	23229519
Pubmed	Emx2 lineage tracing reveals antecedent patterns of planar polarity in the mouse inner ear.	OTOL1 OCM2 OCM	2.94e-07	10	48	3	38682291
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	NAP1L1 PLA2G4A USP10 ATP1A1 EIF4ENIF1 PCM1	1.42e-06	256	48	6	33397691
Pubmed	The Ca2+(-)binding proteins parvalbumin and oncomodulin and their genes: new structural and functional findings.	OCM2 OCM	1.87e-06	2	48	2	8611623
Pubmed	The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability.	PRKX PRKY	1.87e-06	2	48	2	7633447
Pubmed	Structure and chromosomal localization of the mouse oncomodulin gene.	OCM2 OCM	1.87e-06	2	48	2	8597631
Pubmed	Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson's disease.	CACNA1E NCS1	1.87e-06	2	48	2	31704946
Pubmed	Isolation and expression of two zebrafish homologues of parvalbumin genes related to chicken CPV3 and mammalian oncomodulin.	OCM2 OCM	1.87e-06	2	48	2	14516679
Pubmed	Blocking the R-type (Cav2.3) Ca2+ channel enhanced morphine analgesia and reduced morphine tolerance.	CACNA1B CACNA1E	1.87e-06	2	48	2	15610184
Pubmed	Retroviral long terminal repeat is the promoter of the gene encoding the tumor-associated calcium-binding protein oncomodulin in the rat.	OCM2 OCM	1.87e-06	2	48	2	2474657
Pubmed	Effects of ablation of N- and R-type Ca(2+) channels on pain transmission.	CACNA1B CACNA1E	1.87e-06	2	48	2	12074836
Pubmed	NCS-1 Deficiency Affects mRNA Levels of Genes Involved in Regulation of ATP Synthesis and Mitochondrial Stress in Highly Vulnerable Substantia nigra Dopaminergic Neurons.	CACNA1E NCS1	1.87e-06	2	48	2	31827421
Pubmed	PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation.	PRKX PRKY	1.87e-06	2	48	2	21684272
Pubmed	Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females.	PRKX PRKY	1.87e-06	2	48	2	9302280
Pubmed	Disulfide-linked dimer of oncomodulin: comparison to calmodulin.	OCM2 OCM	1.87e-06	2	48	2	3179268
Pubmed	Man to mouse--lessons learned from the distal end of the human X chromosome.	PRKX PRKY	1.87e-06	2	48	2	9414316
Pubmed	Profiles of PrKX expression in developmental mouse embryo and human tissues.	PRKX PRKY	1.87e-06	2	48	2	15879576
Pubmed	Oncomodulin regulates spontaneous calcium signalling and maturation of afferent innervation in cochlear outer hair cells.	OCM2 OCM	1.87e-06	2	48	2	37642186
Pubmed	A novel murine PKA-related protein kinase involved in neuronal differentiation.	PRKX PRKY	1.87e-06	2	48	2	10729225
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	CACNA1B CACNA1E USP10 CAT CHD6 TRAPPC9 PCM1	3.85e-06	475	48	7	31040226
Pubmed	The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.	CACNA1B CACNA1E	5.59e-06	3	48	2	38996073
Pubmed	Human alpha and beta parvalbumins. Structure and tissue-specific expression.	OCM2 OCM	5.59e-06	3	48	2	8354278
Pubmed	The intracisternal A particle derived solo LTR promoter of the rat oncomodulin gene is not present in the mouse gene.	OCM2 OCM	5.59e-06	3	48	2	1468649
Pubmed	Deletion of Oncomodulin Gives Rise to Early Progressive Cochlear Dysfunction in C57 and CBA Mice.	OCM2 OCM	5.59e-06	3	48	2	34867279
Pubmed	Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency.	PRKX PRKY	5.59e-06	3	48	2	17980165
Pubmed	The Conditioning Lesion Response in Dorsal Root Ganglion Neurons Is Inhibited in Oncomodulin Knock-Out Mice.	OCM2 OCM	5.59e-06	3	48	2	35131866
Pubmed	Inhibition of glutathione reductase by oncomodulin.	OCM2 OCM	5.59e-06	3	48	2	2306116
Pubmed	Identification of a VxP Targeting Signal in the Flagellar Na+ /K+ -ATPase.	ATP1A1 ATP1A4	5.59e-06	3	48	2	26373354
Pubmed	Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.	CACNA1B CACNA1E	5.59e-06	3	48	2	24523520
Pubmed	FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12-->q13.	PRKX PRKY	5.59e-06	3	48	2	9154127
Pubmed	Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors.	OCM2 OCM	5.59e-06	3	48	2	22615390
Pubmed	Upregulated expression of oncomodulin, the beta isoform of parvalbumin, in perikarya and axons in the diencephalon of parvalbumin knockout mice.	OCM2 OCM	5.59e-06	3	48	2	19874871
Pubmed	Oncomodulin, an EF-Hand Ca2+ Buffer, Is Critical for Maintaining Cochlear Function in Mice.	OCM2 OCM	5.59e-06	3	48	2	26843644
Pubmed	The genes for the highly homologous Ca(2+)-binding proteins oncomodulin and parvalbumin are not linked in the human genome.	OCM2 OCM	5.59e-06	3	48	2	1559707
Pubmed	SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.	NAP1L1 USP10 CAT ATP1A1 MYH13 ATP1A4 MGA	1.10e-05	558	48	7	27591049
Pubmed	Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.	CACNA1B CACNA1E	1.12e-05	4	48	2	32616470
Pubmed	Cerebellar granule cell signaling is indispensable for normal motor performance.	CACNA1B CACNA1E	1.12e-05	4	48	2	37141091
Pubmed	The Na,K-ATPase alpha4 isoform from humans has distinct enzymatic properties and is important for sperm motility.	ATP1A1 ATP1A4	1.12e-05	4	48	2	16861705
Pubmed	Structure of the Eps15-stonin2 complex provides a molecular explanation for EH-domain ligand specificity.	EPS15 STON2	1.12e-05	4	48	2	18200045
Pubmed	Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia.	ATP1A1 ATP1A4	1.12e-05	4	48	2	21849490
Pubmed	Nanogel-mediated delivery of oncomodulin secreted from regeneration-associated macrophages promotes sensory axon regeneration in the spinal cord.	OCM2 OCM	1.12e-05	4	48	2	35966584
Pubmed	Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism.	ATP1A1 ATP1A4	1.12e-05	4	48	2	2887455
Pubmed	Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells.	OCM2 OCM	1.12e-05	4	48	2	35797824
Pubmed	Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.	CACNA1B CACNA1E	1.86e-05	5	48	2	8825650
Pubmed	Multiple genes encode the human Na+,K+-ATPase catalytic subunit.	ATP1A1 ATP1A4	1.86e-05	5	48	2	3035563
Pubmed	Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.	CACNA1B CACNA1E	1.86e-05	5	48	2	11296258
Pubmed	Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.	CACNA1B CACNA1E	1.86e-05	5	48	2	15451373
Pubmed	Advanced glycation end products inhibit Na+ K+ ATPase in proximal tubule epithelial cells: role of cytosolic phospholipase A2alpha and phosphatidylinositol 4-phosphate 5-kinase gamma.	PLA2G4A ATP1A1	1.86e-05	5	48	2	20435073
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	NAP1L1 PIK3R4 KNDC1 USP10 ATP1A1 ELP3 TRAPPC9 CYRIB PCM1 STON2	2.11e-05	1431	48	10	37142655
Pubmed	The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit.	ATP1A1 ATP1A4	2.79e-05	6	48	2	3036582
Pubmed	An action potential initiation mechanism in distal axons for the control of dopamine release.	CACNA1B CACNA1E	2.79e-05	6	48	2	35324301
Pubmed	Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.	CACNA1B CACNA1E	2.79e-05	6	48	2	9238069
Pubmed	Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.	CACNA1B CACNA1E	2.79e-05	6	48	2	12827191
Pubmed	Celsr1 coordinates the planar polarity of vestibular hair cells during inner ear development.	OCM2 OCM	2.79e-05	6	48	2	28159525
Pubmed	Differential involvement of Na(+),K(+)-ATPase isozymes in preimplantation development of the mouse.	ATP1A1 ATP1A4	3.90e-05	7	48	2	10837135
Pubmed	Oncomodulin identifies different hair cell types in the mammalian inner ear.	OCM2 OCM	3.90e-05	7	48	2	20653034
Pubmed	Rebuilding essential active zone functions within a synapse.	CACNA1B CACNA1E	3.90e-05	7	48	2	35176221
Pubmed	Molecular genetics of Na,K-ATPase.	ATP1A1 ATP1A4	3.90e-05	7	48	2	2158121
Pubmed	Comparison of phenotypes between different vangl2 mutants demonstrates dominant effects of the Looptail mutation during hair cell development.	OCM2 OCM	5.19e-05	8	48	2	22363783
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1B CACNA1E	5.19e-05	8	48	2	28330839
Pubmed	Fgf8 genetic labeling reveals the early specification of vestibular hair cell type in mouse utricle.	OCM2 OCM	5.19e-05	8	48	2	33046506
Pubmed	Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery.	EPS15 STON2	5.19e-05	8	48	2	11381094
Pubmed	Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing.	PRKX PRKY	5.19e-05	8	48	2	22641646
Pubmed	Increased Type I and Decreased Type II Hair Cells after Deletion of Sox2 in the Developing Mouse Utricle.	OCM2 OCM	5.19e-05	8	48	2	31678344
Pubmed	NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer.	USP10 CAT DGCR8 EIF4ENIF1	6.34e-05	155	48	4	33838681
Pubmed	Retinoic acid synthesis and autoregulation mediate zonal patterning of vestibular organs and inner ear morphogenesis.	OCM2 OCM	6.67e-05	9	48	2	32665247
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1B CACNA1E	6.67e-05	9	48	2	16382099
Pubmed	The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea.	OCM2 OCM	6.67e-05	9	48	2	30157434
Pubmed	The postnatal accumulation of junctional E-cadherin is inversely correlated with the capacity for supporting cells to convert directly into sensory hair cells in mammalian balance organs.	OCM2 OCM	6.67e-05	9	48	2	21849546
Pubmed	Domineering non-autonomy in Vangl1;Vangl2 double mutants demonstrates intercellular PCP signaling in the vertebrate inner ear.	OCM2 OCM	8.33e-05	10	48	2	29510119
Pubmed	Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus.	ATP1A1 ATP1A4	1.02e-04	11	48	2	28746879
Pubmed	Gonadal Identity in the Absence of Pro-Testis Factor SOX9 and Pro-Ovary Factor Beta-Catenin in Mice.	DMRT1 CYP11A1	1.22e-04	12	48	2	26108792
Pubmed	Characterization of spatial and temporal development of Type I and Type II hair cells in the mouse utricle using new cell-type-specific markers.	OCM2 OCM	1.22e-04	12	48	2	30455179
Pubmed	Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations.	OCM2 OCM	1.22e-04	12	48	2	31896743
Pubmed	USP51 promotes deubiquitination and stabilization of ZEB1.	USP26 USP10	1.44e-04	13	48	2	29119051
Pubmed	Fbxo2VHC mouse and embryonic stem cell reporter lines delineate in vitro-generated inner ear sensory epithelia cells and enable otic lineage selection and Cre-recombination.	OCM2 OCM	1.44e-04	13	48	2	30179592
Pubmed	Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells.	OCM2 OCM	1.68e-04	14	48	2	28266911
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	KNDC1 USP10 EPS15 KMT2C CHD6 PRKX TRAPPC9 PCM1 NCS1	1.75e-04	1489	48	9	28611215
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1B CACNA1E	1.94e-04	15	48	2	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1B CACNA1E	1.94e-04	15	48	2	24453333
Pubmed	A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.	CACNA1B OCM2 OCM	2.25e-04	85	48	3	23055939
Pubmed	Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development.	NDST3 GALT SGSH	2.66e-04	90	48	3	30228991
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	EPS15 CHD6 EIF4ENIF1 MGA PCM1	2.74e-04	418	48	5	34709266
Pubmed	RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation.	USP10 PCM1	2.81e-04	18	48	2	27558965
Pubmed	Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse.	OCM2 OCM	2.81e-04	18	48	2	33087486
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	CACNA1E KMT2C MYH13 PLK5	3.03e-04	233	48	4	37704626
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	EPS15 AATK EIF4ENIF1 MGA STON2	3.12e-04	430	48	5	35044719
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNA1E USP10 EPS15 MGA CYRIB PCM1 STON2	3.34e-04	963	48	7	28671696
Pubmed	Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation.	DMRT1 CYP11A1	3.49e-04	20	48	2	21385577
Pubmed	In silico QTL mapping of basal liver iron levels in inbred mouse strains.	OCM2 OCM	3.85e-04	21	48	2	21062905
Pubmed	Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model.	CAT CYP11A1	3.85e-04	21	48	2	9616220
Pubmed	Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals.	DMRT1 CYP11A1	3.85e-04	21	48	2	23300469
Pubmed	TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway.	DMRT1 CYP11A1	4.23e-04	22	48	2	35906245
Pubmed	Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1.	OCM2 OCM	4.23e-04	22	48	2	30305733
Pubmed	Tbx2 is a master regulator of inner versus outer hair cell differentiation.	OCM2 OCM	4.63e-04	23	48	2	35508658
Pubmed	Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation.	DMRT1 CYP11A1	4.63e-04	23	48	2	25775596
Pubmed	Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis.	ATP1A1 PCM1	5.05e-04	24	48	2	22333836
Pubmed	Insights into the ubiquitin-proteasome system of human embryonic stem cells.	PIK3R4 ATP1A1 ATP1A4 PCM1	5.21e-04	269	48	4	29511261
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	NAP1L1 PIK3R4 KNDC1 EPS15 EIF4ENIF1 PRKX NCS1	5.23e-04	1038	48	7	26673895
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	PIK3R4 KMT2C ATP1A1 MYH13 HYDIN	6.03e-04	497	48	5	36774506
GeneFamily	EF-hand domain containing	CACNA1B CACNA1E EPS15 OCM2 OCM NCS1	1.37e-06	219	30	6	863
GeneFamily	ATPase Na+/K+ transporting subunits	ATP1A1 ATP1A4	5.56e-05	7	30	2	1208
GeneFamily	Calcium voltage-gated channel subunits	CACNA1B CACNA1E	8.44e-04	26	30	2	253
GeneFamily	Ubiquitin specific peptidases	USP26 USP10	3.88e-03	56	30	2	366
Coexpression	GSE2770_IL12_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_6H_DN	NAP1L1 USP10 EPS15 GALC EIF4ENIF1 TRAPPC9	1.67e-06	199	48	6	M6060
ToppCell	LPS_only-Epithelial_alveolar-AT_2\|LPS_only / Treatment groups by lineage, cell group, cell type	PLA2G4A CAT PPA1 ATP1A1 PLXNB2	2.30e-06	198	48	5	d087e738d69ca9853553fde46d4e7a8906439d32
ToppCell	Influenza_Severe-Neutrophil\|Influenza_Severe / Disease group and Cell class	NDST3 CACNA1E USP10 AATK	2.72e-05	161	48	4	98c95b1b85d5427415af2ca8fb14849e97f6e8b5
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1B PLA2G4A KMT2C CHD6	3.21e-05	168	48	4	8072d0496b7b730c4601009eaa69ec5366d26d73
ToppCell	Influenza_Severe-Neutrophil\|World / Disease group and Cell class	NDST3 CACNA1E USP10 AATK	3.29e-05	169	48	4	6e8e2580e19c96bcf7fa6a6d8c183df65f428396
ToppCell	severe_influenza-Neutrophil\|severe_influenza / disease group, cell group and cell class (v2)	NDST3 CACNA1E USP10 AATK	3.60e-05	173	48	4	615e266419b9f06e964eff73cb466f05451ba0dd
ToppCell	facs-Trachea-24m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KNDC1 DMRT1 DNAJB3 PLK5	3.68e-05	174	48	4	f1510b0f7771936adf29ae3572feab55db31832b
ToppCell	facs-Trachea-24m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell-ciliated_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KNDC1 DMRT1 DNAJB3 PLK5	3.68e-05	174	48	4	5d5d2fc60afff47f997751e8e9ca1367a22d19ec
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NAP1L1 CC2D2A CACNA1E PCM1	4.11e-05	179	48	4	d15182c668d7c37be8214cad9f1fe35d1409c9a1
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NAP1L1 CC2D2A CACNA1E PCM1	4.11e-05	179	48	4	e22a275a7c0ed19113c833a75d6c49fcc19aa13a
ToppCell	Influenza_Severe-Non-classical_Monocyte\|Influenza_Severe / Disease group and Cell class	NAP1L1 KNDC1 PLXNB2 ULK2	5.29e-05	191	48	4	197edf6feb1cfc71d88e532d74f77305a42a3486
ToppCell	severe-Myeloid-CD16_Monocytes\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	NAP1L1 KNDC1 ATP1A1 PLXNB2	5.62e-05	194	48	4	1b33248b8a7cb914783bcf9e6a80481b4db7e0e8
ToppCell	356C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	NAP1L1 USP10 PPA1 ATP1A1	5.62e-05	194	48	4	01eab9f799a0bf4af1f2bffedaa1d926d98abe0f
ToppCell	severe_influenza-Non-classical_Monocyte\|severe_influenza / disease group, cell group and cell class (v2)	NAP1L1 KNDC1 PLXNB2 ULK2	5.62e-05	194	48	4	7630e223666fb65743e21e045478f687dd739a54
ToppCell	severe-Myeloid-CD16_Monocytes\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	NAP1L1 KNDC1 ATP1A1 PLXNB2	5.73e-05	195	48	4	5badcfdeed2fb7453a9c144506ca91c5475cd35f
ToppCell	control-Myeloid-CD16_Monocytes\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	NAP1L1 KNDC1 PLXNB2 ULK2	5.73e-05	195	48	4	f398d08a23fdfa6202f73a7aeac3ff4c997fbdfd
ToppCell	Multiple_Sclerosis-Lymphocyte-T_NK-CD4_TCM\|Multiple_Sclerosis / Disease, Lineage and Cell Type	NAP1L1 USP10 PPA1 GALT	5.85e-05	196	48	4	30c31f3d2c1fb3667c5c7f2057eca067dcd69e4d
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2-AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PLA2G4A CAT PPA1 ATP1A1	5.97e-05	197	48	4	ad6f047d003c08413264f39a30ba0f7639a257cd
ToppCell	control-Myeloid-CD16_Monocytes\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	NAP1L1 KNDC1 PLXNB2 ULK2	5.97e-05	197	48	4	cdb2866d5a8fbf39847309124479ad49c88852d4
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PLA2G4A CAT PPA1 ATP1A1	6.08e-05	198	48	4	c4e7512f0e1d115f2be8acae6048eda8b6b640b2
ToppCell	356C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	NAP1L1 USP10 PPA1 GALT	6.08e-05	198	48	4	0f25a3bf2af543267b43e56064ad06dfc18c7bd7
ToppCell	LPS_only-Epithelial_alveolar\|LPS_only / Treatment groups by lineage, cell group, cell type	CAT PPA1 ATP1A1 PLXNB2	6.08e-05	198	48	4	655df75b9692d815c7f6910275e1f684ac63bf62
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PLA2G4A CAT ATP1A1 PLXNB2	6.08e-05	198	48	4	285f729140b1df029c24f6ca1d2438470ac51794
ToppCell	LPS_only-Epithelial_alveolar-AT_1-2_Progenitor-AT2_Progenitor\|LPS_only / Treatment groups by lineage, cell group, cell type	CAT PPA1 ATP1A1 PLXNB2	6.20e-05	199	48	4	7b21447bb39cdba37539a12cb475f463010fc23f
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Mast_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PLA2G4A GALC PRKX NCS1	6.33e-05	200	48	4	9156f8fd61a833891d2f7b7fadd693b81b1e2d5a
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	NDST3 PLA2G4A CAT HYDIN	6.33e-05	200	48	4	0f23e72649a274043bf23e0952a9b5707c516acf
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Mast_cell-Mast_cell\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PLA2G4A GALC PRKX NCS1	6.33e-05	200	48	4	566fe2e78e6f35399ec6aad5964f6d4d8ade82c6
ToppCell	Influenza-Influenza_Severe-Myeloid-CD16+_Monocyte\|Influenza_Severe / Disease, condition lineage and cell class	NAP1L1 KNDC1 PLXNB2 ULK2	6.33e-05	200	48	4	1efdcfcd86e99fbe03db19a2a5ab10808eec282d
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Cortical_neuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	NDST3 CACNA1E PTPRO NCS1	6.33e-05	200	48	4	44bc4d6616fc8d0ad8498e56125939034e8cff01
ToppCell	MS-Multiple_Sclerosis-Lymphocyte-T/NK-CD4+_Tcm\|Multiple_Sclerosis / Disease, condition lineage and cell class	NAP1L1 USP10 PPA1 GALT	6.33e-05	200	48	4	33546f8d533c7e7ebd29b917b868352fb5bf24a9
Drug	norcepharadione B	CACNA1B CACNA1E	4.35e-06	2	48	2	CID000189168
Drug	aristolactam AII	CACNA1B CACNA1E	4.35e-06	2	48	2	CID000148657
Drug	alkosin	CACNA1B CACNA1E	4.35e-06	2	48	2	CID005488638
Drug	piperolactam A	CACNA1B CACNA1E	4.35e-06	2	48	2	CID003081016
Disease	Seizures	CACNA1B CACNA1E CAT GALC ATP1A1 CYP11A1 SGSH	4.57e-08	218	46	7	C0036572
Disease	familial hemiplegic migraine 1 (implicated_via_orthology)	CACNA1B CACNA1E	7.13e-06	3	46	2	DOID:0111181 (implicated_via_orthology)
Disease	migraine (implicated_via_orthology)	CACNA1B CACNA1E	1.42e-05	4	46	2	DOID:6364 (implicated_via_orthology)
Disease	cups of coffee per day measurement	ATP1A1 ATP1A4 CYP11A1	3.36e-05	40	46	3	EFO_0006782
Disease	familial hemiplegic migraine (implicated_via_orthology)	ATP1A1 ATP1A4	4.97e-05	7	46	2	DOID:0060178 (implicated_via_orthology)
Disease	hereditary ataxia (implicated_via_orthology)	CACNA1B CACNA1E	4.97e-05	7	46	2	DOID:0050951 (implicated_via_orthology)
Disease	sensorineural hearing loss (biomarker_via_orthology)	CAT ATP1A1	6.62e-05	8	46	2	DOID:10003 (biomarker_via_orthology)
Disease	epilepsy (implicated_via_orthology)	CACNA1B CACNA1E ATP1A1 ATP1A4	1.22e-04	163	46	4	DOID:1826 (implicated_via_orthology)
Disease	nervous system disease (implicated_via_orthology)	ATP1A1 ATP1A4	1.55e-04	12	46	2	DOID:863 (implicated_via_orthology)
Disease	Schizophrenia	NDST3 CACNA1B PLA2G4A DGCR8 PCM1 NCS1 STON2	4.06e-04	883	46	7	C0036341
Disease	Intellectual Disability	CACNA1B CACNA1E KMT2C ATP1A1 GALT	6.41e-04	447	46	5	C3714756
Disease	peptide measurement	CACNA1B PLA2G4A DMRT1	6.63e-04	109	46	3	EFO_0010520
Disease	Bipolar Disorder	NDST3 CACNA1B PLA2G4A ATP1A1 NCS1	8.58e-04	477	46	5	C0005586

Protein segments in the cluster

Peptide	Gene	Start	Entry
FPKQVFADDPDTSGF	USP26	416	Q9BXU7
FNQAETFPFNPFDLT	CAT	286	P04040
FNDGTPSANFDTFPA	CACNA1E	631	Q15878
QFNFFETPALFQDPS	ADGRG2	511	Q8IZP9
NFFECENPSEPFGAS	DGCR8	531	Q8WYQ5
NFQDETPTTNFDTFP	CACNA1B	636	Q00975
DFFPVPSNVTTDFLF	NDST3	651	O95803
TVSNDSFFNFFAPPE	NAP1L1	291	P55209
SFFNFFAPPEVPESG	NAP1L1	296	P55209
QEFFPDQGSSGPESF	MINDY3	366	Q9H8M7
PRVEFDDNNPFSESF	KMT2C	3381	Q8NEZ4
FPFGDPTKFATFVFN	NCS1	56	P62166
PGVHTFTFPQTEFFA	MGA	221	Q8IWI9
PDEQFPEGFQFDTDD	ATP1A1	561	P05023
PEGFQFDTDDVNFPI	ATP1A1	566	P05023
FSPLFPSNFGDFSQN	PCM1	1141	Q15154
AGAFEYVPDPTFENF	PLXNB2	1086	O15031
VTFFDVSEQNAPAPF	FAM214B	391	Q7L5A3
QDDFFTQGFTPDRLP	PLK5	61	Q496M5
DPDTFEPQKFFQTSG	OCM2	21	P0CE71
NYFFEFEEFNSTLPP	PTPRO	66	Q16827
DPDTFEPQKFFQTSG	OCM	21	P0CE72
VPANSEGTFSFEFQP	HYDIN	4881	Q4G0P3
AYNFFTFNFDPEPEG	CC2D2A	191	Q9P2K1
PSQFPSETAFLEEFG	CHD6	646	Q8TD26
PADVFREFFGGQDPF	DNAJB3	96	Q8WWF6
NPQYDSTFLFDNDFP	GALT	86	P07902
ALGREPTFFFDPENF	CYP11A1	421	P05108
FTEFFENPAFRPDGL	ELP3	301	Q9H9T3
PDGKPENEFAFNAEF	PPA1	196	Q15181
AFVPPEFDVTGNTFE	KNDC1	106	Q76NI1
GPNFFLDFENAQPTE	CYRIB	16	Q9NUQ9
PVADTNLDFFQSDPF	EPS15	611	P42566
NLDFFQSDPFVGSDP	EPS15	616	P42566
VDYPFFSEAPNFADQ	GALC	496	P54803
GQSVPQFFTFEDAPS	DMRT1	301	Q9Y5R6
PFENFTLDPADFFLN	OTOL1	86	A6NHN0
FDDPESPFSTFNFQY	PLA2G4A	671	P47712
FNPSFAFSSHFDPDG	AATK	6	Q6ZMQ8
EMLSGFPPFFDDNPF	PRKY	236	O43930
FPIDQDFYVSPTFQD	SGSH	396	P51688
SPINPFSAFFEEQER	STON2	326	Q8WXE9
VLPEQSPGDFDFNEF	EIF4ENIF1	296	Q9NRA8
FSKGFPFNTDEINFP	ATP1A4	571	Q13733
PEDNPADFNYFFDTS	PIK3R4	176	Q99570
FPFSDPEDDFQTDFS	ZC3H6	406	P61129
STNPFDFPFVSQGEV	MYH13	306	Q9UKX3
EMLSGFPPFFDDNPF	PRKX	236	P51817
FASAQFPNGPQFAED	TIMM17A	136	Q99595
DFEAFFSHPFLEQGP	ULK2	261	Q8IYT8
PQYIFGDFSPDEFNQ	USP10	6	Q14694
GDFSPDEFNQFFVTP	USP10	11	Q14694
QVDKFNFESFPESPG	TRAPPC9	941	Q96Q05