Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	pheromone receptor activity	VN1R2 VN1R1	9.91e-05	6	52	2	GO:0016503
Domain	NACHT-assoc	NLRP12 NLRP3	7.31e-06	2	51	2	IPR029495
Domain	FISNA	NLRP12 NLRP3	7.31e-06	2	51	2	PF14484
Domain	FISNA	NLRP12 NLRP3	7.31e-06	2	51	2	SM01288
Domain	Vmron_rcpt_1	VN1R2 VN1R1	7.27e-05	5	51	2	IPR004072
Domain	V1R	VN1R2 VN1R1	7.27e-05	5	51	2	PF03402
Domain	-	EYS NRXN2 LAMA3 ADGRG4	1.31e-04	95	51	4	2.60.120.200
Domain	LAM_G_DOMAIN	EYS NRXN2 LAMA3	1.51e-04	38	51	3	PS50025
Domain	Laminin_G_2	EYS NRXN2 LAMA3	1.76e-04	40	51	3	PF02210
Domain	LamG	EYS NRXN2 LAMA3	2.35e-04	44	51	3	SM00282
Domain	ConA-like_dom	TRIM69 EYS NRXN2 LAMA3 ADGRG4	3.21e-04	219	51	5	IPR013320
Domain	Laminin_G	EYS NRXN2 LAMA3	5.32e-04	58	51	3	IPR001791
Domain	DAPIN	NLRP12 NLRP3	1.63e-03	22	51	2	PS50824
Domain	PYRIN	NLRP12 NLRP3	1.63e-03	22	51	2	PF02758
Domain	DAPIN	NLRP12 NLRP3	1.63e-03	22	51	2	IPR004020
Domain	PYRIN	NLRP12 NLRP3	1.63e-03	22	51	2	SM01289
Domain	NACHT	NLRP12 NLRP3	1.78e-03	23	51	2	PS50837
Domain	NACHT_NTPase	NLRP12 NLRP3	1.78e-03	23	51	2	IPR007111
Domain	GPCR_Rhodpsn_7TM	OR2T8 VN1R2 OR2T33 OR8K5 OR8K3 OR2T12 VN1R1	2.17e-03	670	51	7	IPR017452
Domain	G_PROTEIN_RECEP_F1_1	OR2T8 VN1R2 OR2T33 OR8K5 OR8K3 OR2T12 VN1R1	2.46e-03	685	51	7	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2T8 VN1R2 OR2T33 OR8K5 OR8K3 OR2T12 VN1R1	2.59e-03	691	51	7	PS50262
Domain	GPCR_Rhodpsn	OR2T8 VN1R2 OR2T33 OR8K5 OR8K3 OR2T12 VN1R1	2.61e-03	692	51	7	IPR000276
Domain	EGF	FRAS1 EYS NRXN2 LAMA3	3.84e-03	235	51	4	SM00181
Domain	Olfact_rcpt	OR2T8 OR2T33 OR8K5 OR8K3 OR2T12	4.27e-03	393	51	5	IPR000725
Domain	EGF-like_dom	FRAS1 EYS NRXN2 LAMA3	4.72e-03	249	51	4	IPR000742
Domain	GDS_CDC24_CS	PLEKHG4 VAV2	5.08e-03	39	51	2	IPR001331
Pubmed	The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity.	PARP1 TOP1 HDAC1	8.92e-07	13	52	3	17158748
Pubmed	Interaction of DNA topoisomerase 1 with DNA intermediates and proteins of base excision repair.	PARP1 TOP1	2.19e-06	2	52	2	19916945
Pubmed	Poly(ADP-ribose) polymerase signaling of topoisomerase 1-dependent DNA damage in carcinoma cells.	PARP1 TOP1	2.19e-06	2	52	2	20875401
Pubmed	Xenobiotic pregnane X receptor (PXR) regulates innate immunity via activation of NLRP3 inflammasome in vascular endothelial cells.	NR1I2 NLRP3	2.19e-06	2	52	2	25202020
Pubmed	Inhibited CSF1R Alleviates Ischemia Injury via Inhibition of Microglia M1 Polarization and NLRP3 Pathway.	CSF1R NLRP3	2.19e-06	2	52	2	32908485
Pubmed	Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes.	PARP1 TOP1	2.19e-06	2	52	2	22158865
Pubmed	Rare mutations in NLRP3 and NLRP12 associated with familial cold autoinflammatory syndrome: two Chinese pedigrees.	NLRP12 NLRP3	2.19e-06	2	52	2	35852776
Pubmed	Mycoplasma fermentans inhibits the activity of cellular DNA topoisomerase I by activation of PARP1 and alters the efficacy of its anti-cancer inhibitor.	PARP1 TOP1	2.19e-06	2	52	2	24013388
Pubmed	A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes.	PARP1 TOP1	2.19e-06	2	52	2	18515798
Pubmed	NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome.	NLRP12 NLRP3	2.19e-06	2	52	2	38261657
Pubmed	Poly(ADP-ribosyl)ation as a DNA damage-induced post-translational modification regulating poly(ADP-ribose) polymerase-1-topoisomerase I interaction.	PARP1 TOP1	2.19e-06	2	52	2	15247263
Pubmed	Studies on the mechanism of local and extra-intestinal tissue manifestations in AOM-DSS-induced carcinogenesis in BALB/c mice: role of PARP-1, NLRP3, and autophagy.	PARP1 NLRP3	2.19e-06	2	52	2	38091080
Pubmed	Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity.	NLRP12 NLRP3	2.19e-06	2	52	2	20861349
Pubmed	ETO2 coordinates cellular proliferation and differentiation during erythropoiesis.	PARP1 TOP1 HDAC1	3.53e-06	20	52	3	16407974
Pubmed	Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors.	GPRC6A NLRP3	6.57e-06	3	52	2	23271661
Pubmed	Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation.	PARP1 NLRP3	6.57e-06	3	52	2	27010854
Pubmed	The involvement of Sting in exacerbating acute lung injury in sepsis via the PARP-1/NLRP3 signaling pathway.	PARP1 NLRP3	6.57e-06	3	52	2	38848887
Pubmed	PARP-1 regulates inflammasome activity by poly-ADP-ribosylation of NLRP3 and interaction with TXNIP in primary macrophages.	PARP1 NLRP3	6.57e-06	3	52	2	35098371
Pubmed	NLRP12 c.1382dup promotes the development of Crohn's disease through the ERK/NLRP3/ IL-1β pathway.	NLRP12 NLRP3	6.57e-06	3	52	2	39181275
Pubmed	Poly(ADP-ribosyl)ation of OVOL2 regulates aneuploidy and cell death in cancer cells.	PARP1 HDAC1	6.57e-06	3	52	2	30542118
Pubmed	Contribution of guanine nucleotide exchange factor Vav2 to NLRP3 inflammasome activation in mouse podocytes during hyperhomocysteinemia.	VAV2 NLRP3	6.57e-06	3	52	2	28193546
Pubmed	Cutting edge: proteolytic inactivation of poly(ADP-ribose) polymerase 1 by the Nlrp3 and Nlrc4 inflammasomes.	PARP1 NLRP3	1.31e-05	4	52	2	20713892
Pubmed	Association of EGF Receptor and NLRs signaling with Cardiac Inflammation and Fibrosis in Mice Exposed to Fine Particulate Matter.	NLRP12 NLRP3	1.31e-05	4	52	2	27158778
Pubmed	GPRC6A mediates Alum-induced Nlrp3 inflammasome activation but limits Th2 type antibody responses.	GPRC6A NLRP3	1.31e-05	4	52	2	26602597
Pubmed	NLRP3, NLRP12, and IFI16 Inflammasomes Induction and Caspase-1 Activation Triggered by Virulent HSV-1 Strains Are Associated With Severe Corneal Inflammatory Herpetic Disease.	NLRP12 NLRP3	1.31e-05	4	52	2	31367214
Pubmed	Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan.	PARP1 TOP1	1.31e-05	4	52	2	19604089
Pubmed	Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue.	PARP1 TOP1	1.31e-05	4	52	2	11756244
Pubmed	Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment.	NLRP12 NLRP3	2.19e-05	5	52	2	27779193
Pubmed	Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1.	NLRP12 NLRP3	2.19e-05	5	52	2	17046979
Pubmed	Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates.	VN1R2 VN1R1	2.19e-05	5	52	2	12826614
Pubmed	Analysis of Human Nuclear Protein Complexes by Quantitative Mass Spectrometry Profiling.	PARP1 HDAC1	2.19e-05	5	52	2	29655301
Pubmed	Downregulation of HERC5 E3 ligase attenuates the ubiquitination of CtBP1 to inhibit apoptosis in colorectal cancer cells.	USP34 NLRP3 HDAC1	2.36e-05	37	52	3	34147029
Pubmed	Evaluation of Nod-like receptor (NLR) effector domain interactions.	NLRP12 NLRP3	3.28e-05	6	52	2	19337385
Pubmed	SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1.	PARP1 HDAC1	3.28e-05	6	52	2	19470756
Pubmed	NLRC4 suppresses melanoma tumor progression independently of inflammasome activation.	NLRP12 NLRP3	3.28e-05	6	52	2	27617861
Pubmed	Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells.	PARP1 NLRP3	3.28e-05	6	52	2	28687790
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	ZNF462 EPRS1 HDAC1	3.73e-05	43	52	3	33472061
Pubmed	Identification of G protein-coupled receptor genes from the human genome sequence.	VN1R2 GPRC6A VN1R1	4.57e-05	46	52	3	12044878
Pubmed	Polymorphisms in NACHT-LRR (NLR) genes in atopic dermatitis.	NLRP12 NLRP3	4.58e-05	7	52	2	17620097
Pubmed	Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1α) docking protein.	PARP1 TOP1	4.58e-05	7	52	2	23213405
Pubmed	Hdac1 and Hdac2 regulate the quiescent state and survival of hair-follicle mesenchymal niche.	NLRP12 HDAC1	4.58e-05	7	52	2	37563109
Pubmed	AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.	NLRP12 NLRP3	4.58e-05	7	52	2	19158675
Pubmed	Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase.	PARP1 TOP1	4.58e-05	7	52	2	12519782
Pubmed	Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells.	PARP1 TOP1	6.10e-05	8	52	2	15640154
Pubmed	The Effect of the NFκB-USP9X-Cx43 Axis on the Dynamic Balance of Bone Formation/Degradation during Ossification of the Posterior Longitudinal Ligament of the Cervical Spine.	PARP1 TRIM69 ACTN1	7.41e-05	54	52	3	35391932
Pubmed	Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.	NLRP12 NLRP3	7.84e-05	9	52	2	24799678
Pubmed	Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.	NLRP12 NLRP3	7.84e-05	9	52	2	24453977
Pubmed	Aerobic glycolysis tunes YAP/TAZ transcriptional activity.	EPRS1 PARP1 ACTN1 HDAC1	1.03e-04	162	52	4	25796446
Pubmed	Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock.	NLRP12 NLRP3	1.20e-04	11	52	2	26572062
Pubmed	USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair.	PARP1 HDAC1	1.43e-04	12	52	2	31504778
Pubmed	Shox2 is required for the proper development of the facial motor nucleus and the establishment of the facial nerves.	SLC18A2 CNTN2	1.43e-04	12	52	2	26156498
Pubmed	The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes.	PARP1 HDAC1	1.43e-04	12	52	2	23708667
Pubmed	Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin.	PARP1 TOP1	1.43e-04	12	52	2	21679440
Pubmed	NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis.	NLRP12 NLRP3	1.43e-04	12	52	2	21565393
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR2T8 OR2T33 OR8K5 OR8K3 OR2T12	1.55e-04	340	52	5	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR2T8 OR2T33 OR8K5 OR8K3 OR2T12	1.55e-04	340	52	5	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR2T8 OR2T33 OR8K5 OR8K3 OR2T12	1.61e-04	343	52	5	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR2T8 OR2T33 OR8K5 OR8K3 OR2T12	1.68e-04	346	52	5	14611657
Pubmed	Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.	PARP1 TOP1 HDAC1	1.68e-04	71	52	3	28319113
Pubmed	Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression.	SLC18A2 HDAC1	1.69e-04	13	52	2	19144721
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	EPRS1 PARP1 TMED2 ACTN1 TOP1 DISP1 VAV2	1.90e-04	807	52	7	30575818
Pubmed	The NLRP12 inflammasome recognizes Yersinia pestis.	NLRP12 NLRP3	1.97e-04	14	52	2	22840842
Pubmed	The genetics of NOD-like receptors in Crohn's disease.	NLRP12 NLRP3	1.97e-04	14	52	2	20403135
Pubmed	NALPs: a novel protein family involved in inflammation.	NLRP12 NLRP3	1.97e-04	14	52	2	12563287
Pubmed	Chfr is linked to tumour metastasis through the downregulation of HDAC1.	PARP1 HDAC1	2.60e-04	16	52	2	19182791
Pubmed	Targeting USP9X-AMPK Axis in ARID1A-Deficient Hepatocellular Carcinoma.	ACTN1 HDAC1	2.60e-04	16	52	2	35390516
Pubmed	Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.	CSF1R VAV2	2.60e-04	16	52	2	10022833
Pubmed	Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.	FRAS1 LAMA3	2.60e-04	16	52	2	16880404
Pubmed	Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.	NLRP12 NLRP3	2.94e-04	17	52	2	22297845
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	PARP1 FRAS1 TOP1 HDAC1	3.27e-04	219	52	4	31353912
Pubmed	IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α.	NRXN2 IGSF21	3.30e-04	18	52	2	28864826
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	ZNF462 USP34 PARP1 HDAC1	3.32e-04	220	52	4	35785414
Pubmed	The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.	PARP1 TOP1	3.69e-04	19	52	2	20504901
Pubmed	Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.	PARP1 HDAC1	3.69e-04	19	52	2	16204234
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	USP34 PARP1 EYS CSF1R HDAC1	4.09e-04	420	52	5	28065597
Pubmed	Ubiquitin-protein ligase E3C maintains non-small-cell lung cancer stemness by targeting AHNAK-p53 complex.	ACTN1 TOP1	4.52e-04	21	52	2	30503554
Pubmed	Oxidized thioredoxin-1 restrains the NLRP1 inflammasome.	DPP9 NLRP3	4.52e-04	21	52	2	36332009
Pubmed	Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.	GPRC6A NLRP3	4.52e-04	21	52	2	21300955
Pubmed	Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.	SCAF11 DISP1	4.97e-04	22	52	2	26631746
Pubmed	Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage.	PARP1 TOP1	4.97e-04	22	52	2	24780295
Pubmed	Cbln1 regulates axon growth and guidance in multiple neural regions.	NRXN2 CNTN2	4.97e-04	22	52	2	36395107
Pubmed	Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.	PARP1 ACTN1 TOP1 HDAC1	4.99e-04	245	52	4	21182205
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	ZNF462 TOP1 HDAC1	5.02e-04	103	52	3	32744500
Pubmed	BDNF and NT4 play interchangeable roles in gustatory development.	CSF1R CNTN2	5.44e-04	23	52	2	24378336
Pubmed	Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.	EPRS1 PARP1 TOP1 HDAC1	6.06e-04	258	52	4	21081666
Pubmed	Chromatin regulation by Brg1 underlies heart muscle development and disease.	PARP1 HDAC1	6.43e-04	25	52	2	20596014
Pubmed	A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.	EPRS1 TRIM69 ACTN1	7.45e-04	118	52	3	27377895
Pubmed	TRAIP regulates replication fork recovery and progression via PCNA.	PARP1 TOP1	7.51e-04	27	52	2	27462463
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	EPRS1 PARP1 ACTN1 TOP1	7.58e-04	274	52	4	34244482
Pubmed	Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.	EPRS1 PARP1 CSF1R TOP1	7.79e-04	276	52	4	28319085
Pubmed	Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.	EPRS1 PARP1 LAMA3 ACTN1 TOP1	8.05e-04	488	52	5	31324722
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	CCNL2 EVI5 OR2T33 OR2T12 IGSF21 CNTN2 NLRP3	8.24e-04	1031	52	7	16710414
Pubmed	Interactome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL.	PARP1 TOP1 HDAC1	8.41e-04	123	52	3	35583604
Pubmed	Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.	FRAS1 LAMA3	8.67e-04	29	52	2	22613833
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	ZNF462 PARP1 FRAS1 CNGB3 TOP1	1.01e-03	513	52	5	25798074
Pubmed	Proteomic analysis of complexes formed by human topoisomerase I.	PARP1 TOP1	1.06e-03	32	52	2	15848144
Pubmed	TXLNA enhances TBK1 phosphorylation by suppressing PPM1B recruitment.	PARP1 SCAMP3 TOP1	1.17e-03	138	52	3	37506885
Pubmed	Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.	ACTN1 NLRP3	1.26e-03	35	52	2	23969696
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	USP34 EPRS1 DPP9 PLPP3 ELOVL5 TMED2 TOP1 HDAC1	1.32e-03	1451	52	8	30550785
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	EPRS1 PARP1 SCAF11 TOP1 HDAC1	1.38e-03	551	52	5	34728620
Interaction	OR2T12 interactions	OR2T33 OR2T12	5.55e-06	2	48	2	int:OR2T12
Interaction	OR2T33 interactions	OR2T33 OR2T12	1.66e-05	3	48	2	int:OR2T33
Interaction	NFYB interactions	PARP1 TOP1 CNTN2 HDAC1	1.72e-05	65	48	4	int:NFYB
Cytoband	1q44	OR2T8 OR2T33 OR2T12 NLRP3	7.73e-06	110	52	4	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2T8 OR2T33 OR2T12 NLRP3	1.41e-05	128	52	4	chr1q44
Cytoband	14q24	ENTPD5 ACTN1	6.88e-05	11	52	2	14q24
Cytoband	1q41	EPRS1 DISP1	2.58e-03	66	52	2	1q41
Cytoband	Ensembl 112 genes in cytogenetic band chr1q41	EPRS1 DISP1	5.04e-03	93	52	2	chr1q41
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP12 NLRP3	1.25e-03	25	38	2	994
GeneFamily	NLR family	NLRP12 NLRP3	1.25e-03	25	38	2	666
GeneFamily	Olfactory receptors, family 2	OR2T8 OR2T33 OR2T12	1.71e-03	113	38	3	149
GeneFamily	Olfactory receptors, family 8	OR8K5 OR8K3	4.75e-03	49	38	2	155
GeneFamily	Immunoglobulin like domain containing	CSF1R IGSF21 CNTN2	7.68e-03	193	38	3	594
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG4 VAV2	8.48e-03	66	38	2	722
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CSF1R NRXN2 UGT1A6 IGSF21 NLRP3	2.05e-06	178	52	5	aa9f68a66e292f331faef881bbd0d028f0f2b0c5
Drug	quinazolin-4(3H)-one	EPRS1 PARP1 PPEF1	4.73e-06	15	51	3	CID000063112
Disease	Familial cold autoinflammatory syndrome	NLRP12 NLRP3	1.55e-05	4	48	2	cv:C0343068
Disease	Arterial Fatty Streak	PARP1 NR1I2	2.58e-05	5	48	2	C0015697
Disease	Atheroma	PARP1 NR1I2	2.58e-05	5	48	2	C0264956
Disease	Plaque, Atherosclerotic	PARP1 NR1I2	2.58e-05	5	48	2	C2936350
Disease	Fibroatheroma	PARP1 NR1I2	2.58e-05	5	48	2	C2936351
Disease	response to platinum based chemotherapy, cytotoxicity measurement	FRAS1 EYS	2.58e-05	5	48	2	EFO_0004647, EFO_0006952
Disease	low density lipoprotein cholesterol measurement, body fat percentage	EVI5 UGT1A6	3.47e-04	17	48	2	EFO_0004611, EFO_0007800
Disease	C-reactive protein measurement	USP34 NR1I2 TRANK1 SCAF11 GPRC6A MFSD4B TOP1 NLRP3	6.70e-04	1206	48	8	EFO_0004458
Disease	eosinophil measurement	USP34 NLRP12 VAV2	7.32e-04	108	48	3	EFO_0803540
Disease	bilirubin measurement	NR1I2 UGT1A6 MFSD4B TOP1 NLRP3	7.43e-04	442	48	5	EFO_0004570
Disease	Autosomal Dominant Parkinsonism	PARP1 SLC18A2	9.53e-04	28	48	2	C0752098
Disease	Autosomal Dominant Juvenile Parkinson Disease	PARP1 SLC18A2	9.53e-04	28	48	2	C0752097
Disease	prostate carcinoma in situ (is_marker_for)	CSF1R HDAC1	9.53e-04	28	48	2	DOID:8634 (is_marker_for)
Disease	Parkinsonism, Experimental	PARP1 SLC18A2	9.53e-04	28	48	2	C0752101
Disease	Autosomal Recessive Parkinsonism	PARP1 SLC18A2	9.53e-04	28	48	2	C0752100
Disease	Familial Juvenile Parkinsonism	PARP1 SLC18A2	9.53e-04	28	48	2	C0752104
Disease	Ramsay Hunt Paralysis Syndrome	PARP1 SLC18A2	9.53e-04	28	48	2	C0242423
Disease	PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE	PARP1 SLC18A2	9.53e-04	28	48	2	C1868675
Disease	non-high density lipoprotein cholesterol measurement	EVI5 USP34 NR1I2 CSF1R UGT1A6 VN1R1	1.01e-03	713	48	6	EFO_0005689
Disease	Parkinsonism, Juvenile	PARP1 SLC18A2	1.09e-03	30	48	2	C0752105
Disease	Parkinsonian Disorders	PARP1 SLC18A2	1.09e-03	30	48	2	C0242422
Disease	Autoinflammatory disorder	NLRP12 NLRP3	1.49e-03	35	48	2	C3860213
Disease	Spinocerebellar Ataxia Type 4	PLEKHG4 ELOVL5	1.49e-03	35	48	2	C0752122

Protein segments in the cluster

Peptide	Gene	Start	Entry
GAYFLFSKMHTSQDF	CEBPZOS	26	A8MTT3
KAIMTYVSSFYHAFS	ACTN1	236	P12814
STVSFYNVEMSFSVF	ADGRG4	2241	Q8IZF6
LSMFVTSFTTAAAFY	DISP1	606	Q96F81
YFADMVSKSANYCHT	PARP1	896	P09874
HFFDTDKMASVFYTL	OR8K5	266	Q8NH50
TNHDKVVSAFYTMFT	OR2T12	266	Q8NG77
TSFEMFNSTYKLYTH	ENTPD5	226	O75356
VTDSFYFSVSDMDHN	FRAS1	1801	Q86XX4
TEISHASQAYFESMF	EYS	2271	Q5T1H1
FHTGTKNSFMALYLS	LAMA3	3026	Q16787
AFYTTDRVMTVSFHK	HDAC1	186	Q13547
MEHFDASLSTYFKAL	ELOVL5	1	Q9NYP7
TNHDKVVSAFYTMFT	OR2T8	266	A6NH00
MESGFTSKDTYLSHF	NNMT	1	P40261
FVHFQSQSFHTSMYA	EVI5	306	O60447
AYASMHLFFQFKTTA	NRXN2	936	Q9P2S2
DAQMKTFDTTFSHFK	NR1I2	156	O75469
TNHDKVVSAFYTMFT	OR2T33	266	Q8NG76
YVFSFATTHAGMKES	MFSD4B	251	Q5TF39
KSAFLKMIYSYSSHS	GPRC6A	846	Q5T6X5
KHSTSMFFRVVESAY	CSF1R	286	P07333
KIFTFDAMFSTNYSH	IGSF21	71	Q96ID5
SMSQNFDMFVSHYSS	DPP9	551	Q86TI2
FQRFFYTKSFVKHSM	CCNL2	106	Q96S94
SHMDFSTKSVFSKFA	CNTN2	211	Q02246
FRNFFSNMFSSVSHS	SCAF11	186	Q99590
MYKAFRSDSSFNFFV	SCAMP3	221	O14828
MFAFSTFEESVSNYS	DSEL	16	Q8IZU8
MKSGDHTAAFSYFQK	DELE1	256	Q14154
TFFSFMLENYTHIHK	PPEF1	61	O14829
KFYSFIHMTFQEFFA	NLRP3	516	Q96P20
FTYTSDHFETIMKYA	EPRS1	266	P07814
FFSTFAKTSMFVLYL	SLC35F5	101	Q8WV83
SDALMSSYGHTFFKD	PLEKHG4	831	Q58EX7
ARKSFFSGHASFSMY	PLPP3	191	O14495
FMYVQPKSSHSFDTD	OR8K3	256	Q8NH51
YTSFFEFNHHLESIM	CNGB3	331	Q9NQW8
FYNAKTMTHIYTFSN	TRIM69	456	Q86WT6
TFFMVTFAALYSTHK	XPR1	486	Q9UBH6
MVLVSSFFVFYSVHS	VN1R1	276	Q9GZP7
TFAAHMDGTYKFCFS	TMED2	81	Q15363
SFYTGFKSAFTMHVE	ZNF462	2226	Q96JM2
HLTSMATSYFGKQFL	TVP23B	181	Q9NYZ1
MDFSFEKTHSAYMLF	USP34	2221	Q70CQ2
ANHHSFQMYTFDKTT	VAV2	521	P52735
YTKFSDHMTFSQRVA	UGT1A6	196	P19224
VETEYNIMKFHSFST	TRANK1	976	O15050
VSTIMFAFSSSYAFL	SLC18A2	171	Q05940
VATFFAKMLDHEYTT	TOP1	256	P11387
ETMATFGLKHFDNYF	VN1R2	146	Q8NFZ6
SFIHLSFQEFFAAMY	NLRP12	511	P59046