Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF132 SP3 SP4 CTCFL ZNF22 ZBTB6 ZIK1 HIVEP1 ZNF680 ZNF569 ZNF718 ZNF366 ZNF549 ZNF423 ZNF667 ZNF506 ZNF799 ZBTB41 ZNF81 ZBTB11 ZNF692 ZNF840P ZNF169 ZFX ZFY	6.83e-15	1459	54	25	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF132 SP3 SP4 CTCFL ZNF22 ZBTB6 ZIK1 HIVEP1 ZNF680 ZNF569 ZNF718 ZNF366 ZNF549 ZNF423 ZNF667 ZNF506 ZBTB41 ZNF81 ZBTB11 ZNF692 ZNF840P ZFX ZFY	2.59e-14	1244	54	23	GO:0000978
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF132 SP3 SP4 CTCFL ZNF22 ZBTB6 ZIK1 HIVEP1 ZNF680 ZNF569 ZNF718 ZNF549 ZNF423 ZNF506 ZNF799 ZBTB41 ZNF81 ZBTB11 ZNF692 ZNF840P ZNF169 ZFX ZFY ZNF292	3.59e-14	1412	54	24	GO:0000981
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF132 SP3 SP4 CTCFL ZNF22 ZBTB6 ZIK1 HIVEP1 ZNF680 ZNF569 ZNF718 ZNF366 ZNF549 ZNF423 ZNF667 ZNF506 ZBTB41 ZNF81 ZBTB11 ZNF692 ZNF840P ZFX ZFY	4.08e-14	1271	54	23	GO:0000987
GeneOntologyMolecularFunction	chromatin insulator sequence binding	CTCFL ZNF692 ZFX ZFY	1.66e-09	7	54	4	GO:0043035
GeneOntologyMolecularFunction	chloride:bicarbonate antiporter activity	SLC26A3 SLC4A8 SLC4A10	5.25e-06	13	54	3	GO:0140900
GeneOntologyMolecularFunction	bicarbonate:monoatomic anion antiporter activity	SLC26A3 SLC4A8 SLC4A10	5.25e-06	13	54	3	GO:0140829
GeneOntologyMolecularFunction	sodium,bicarbonate:chloride antiporter activity	SLC4A8 SLC4A10	2.15e-05	3	54	2	GO:0140892
GeneOntologyMolecularFunction	bicarbonate transmembrane transporter activity	SLC26A3 SLC4A8 SLC4A10	8.77e-05	32	54	3	GO:0015106
GeneOntologyMolecularFunction	solute:inorganic anion antiporter activity	SLC26A3 SLC4A8 SLC4A10	8.77e-05	32	54	3	GO:0005452
GeneOntologyMolecularFunction	sodium:bicarbonate symporter activity	SLC4A8 SLC4A10	1.07e-04	6	54	2	GO:0008510
GeneOntologyMolecularFunction	chromatin binding	SP3 CTCFL ERCC6 HPF1 MCM9 ASH1L ZNF692 ZFX ZFY	1.48e-04	739	54	9	GO:0003682
GeneOntologyMolecularFunction	monoatomic cation:bicarbonate symporter activity	SLC4A8 SLC4A10	5.49e-04	13	54	2	GO:0140410
GeneOntologyMolecularFunction	chromatin DNA binding	CTCFL ZNF692 ZFX ZFY	1.08e-03	167	54	4	GO:0031490
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	SETBP1 ASH1L	1.32e-03	20	54	2	GO:0042800
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	SP3 ZNF22 ZBTB6 HIVEP1 ZNF692	1.70e-03	320	54	5	GO:0001227
GeneOntologyMolecularFunction	histone H4 acetyltransferase activity	MEAF6 USP22	1.75e-03	23	54	2	GO:0010485
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	SP3 ZNF22 ZBTB6 HIVEP1 ZNF692	1.85e-03	326	54	5	GO:0001217
GeneOntologyMolecularFunction	histone modifying activity	MEAF6 USP22 SETBP1 ASH1L	3.40e-03	229	54	4	GO:0140993
GeneOntologyBiologicalProcess	post-embryonic development	TET2 ASH1L SLC4A10 ZFX ZFY	2.73e-05	135	54	5	GO:0009791
GeneOntologyBiologicalProcess	chromatin remodeling	MEAF6 TET2 CTCFL ERCC6 USP22 SETBP1 HPF1 ASH1L ZFY	1.19e-04	741	54	9	GO:0006338
GeneOntologyBiologicalProcess	bicarbonate transport	SLC26A3 SLC4A8 SLC4A10	1.34e-04	38	54	3	GO:0015701
MousePheno	decreased primordial germ cell number	MCM9 ZFX ZFY	4.60e-05	29	34	3	MP:0008392
MousePheno	abnormal primordial germ cell morphology	MCM9 ZFX ZFY	6.82e-05	33	34	3	MP:0008391
Domain	zf-C2H2	ZNF132 SP3 SP4 CTCFL ZNF22 ZBTB6 ZNF775 ZIK1 HIVEP1 ZNF680 ZNF569 ZNF718 ZNF366 ZNF549 ZNF423 ZNF667 ZNF506 ZNF799 ZBTB41 ZNF81 POGZ ZBTB11 ZNF692 ZNF169 ZFX ZFY ZXDB ZNF292	1.94e-26	693	53	28	PF00096
Domain	-	ZNF132 SP3 SP4 CTCFL ZNF22 ZBTB6 ZNF775 ZIK1 HIVEP1 ZNF680 ZNF569 ZNF718 ZNF366 ZNF549 ZNF423 ZNF667 ZNF506 ZNF799 ZBTB41 ZNF81 ZBTB11 ZNF692 ZNF169 ZFX ZFY ZXDB ZNF292	3.29e-25	679	53	27	3.30.160.60
Domain	ZINC_FINGER_C2H2_2	ZNF132 SP3 SP4 CTCFL ZNF22 ZBTB6 ZNF775 ZIK1 HIVEP1 ZNF680 ZNF569 ZNF718 ZNF366 ZNF549 ZNF423 ZNF667 ZNF506 ZNF799 ZBTB41 ZNF81 POGZ ZBTB11 ZNF692 ZNF169 ZFX ZFY ZXDB ZNF292	4.23e-25	775	53	28	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF132 SP3 SP4 CTCFL ZNF22 ZBTB6 ZNF775 ZIK1 HIVEP1 ZNF680 ZNF569 ZNF718 ZNF366 ZNF549 ZNF423 ZNF667 ZNF506 ZNF799 ZBTB41 ZNF81 POGZ ZBTB11 ZNF692 ZNF169 ZFX ZFY ZXDB ZNF292	4.54e-25	777	53	28	PS00028
Domain	Znf_C2H2/integrase_DNA-bd	ZNF132 SP3 SP4 CTCFL ZNF22 ZBTB6 ZNF775 ZIK1 HIVEP1 ZNF680 ZNF569 ZNF718 ZNF366 ZNF549 ZNF423 ZNF667 ZNF506 ZNF799 ZBTB41 ZNF81 ZBTB11 ZNF692 ZNF169 ZFX ZFY ZXDB ZNF292	5.88e-25	694	53	27	IPR013087
Domain	Znf_C2H2-like	ZNF132 SP3 SP4 CTCFL ZNF22 ZBTB6 ZNF775 ZIK1 HIVEP1 ZNF680 ZNF569 ZNF718 ZNF366 ZNF549 ZNF423 ZNF667 ZNF506 ZNF799 ZBTB41 ZNF81 POGZ ZBTB11 ZNF692 ZNF169 ZFX ZFY ZXDB ZNF292	8.80e-25	796	53	28	IPR015880
Domain	Znf_C2H2	ZNF132 SP3 SP4 CTCFL ZNF22 ZBTB6 ZNF775 ZIK1 HIVEP1 ZNF680 ZNF569 ZNF718 ZNF366 ZNF549 ZNF423 ZNF667 ZNF506 ZNF799 ZBTB41 ZNF81 POGZ ZBTB11 ZNF692 ZNF169 ZFX ZFY ZXDB ZNF292	1.20e-24	805	53	28	IPR007087
Domain	ZnF_C2H2	ZNF132 SP3 SP4 CTCFL ZNF22 ZBTB6 ZNF775 ZIK1 HIVEP1 ZNF680 ZNF569 ZNF718 ZNF366 ZNF549 ZNF423 ZNF667 ZNF506 ZNF799 ZBTB41 ZNF81 POGZ ZBTB11 ZNF692 ZNF169 ZFX ZFY ZXDB ZNF292	1.33e-24	808	53	28	SM00355
Domain	zf-C2H2_6	ZNF680 ZNF569 ZNF718 ZNF366 ZNF549 ZNF423 ZNF667 ZNF506 ZNF799 ZBTB41 ZBTB11 ZNF169	5.96e-11	314	53	12	PF13912
Domain	KRAB	ZNF132 ZIK1 ZNF680 ZNF569 ZNF718 ZNF549 ZNF667 ZNF506 ZNF799 ZNF81 ZNF169	4.09e-09	358	53	11	PS50805
Domain	KRAB	ZNF132 ZIK1 ZNF680 ZNF569 ZNF718 ZNF549 ZNF667 ZNF506 ZNF799 ZNF81 ZNF169	4.09e-09	358	53	11	PF01352
Domain	KRAB	ZNF132 ZIK1 ZNF680 ZNF569 ZNF718 ZNF549 ZNF667 ZNF506 ZNF799 ZNF81 ZNF169	5.60e-09	369	53	11	SM00349
Domain	KRAB	ZNF132 ZIK1 ZNF680 ZNF569 ZNF718 ZNF549 ZNF667 ZNF506 ZNF799 ZNF81 ZNF169	5.76e-09	370	53	11	IPR001909
Domain	Transcrp_activ_Zfx/Zfy-dom	ZFX ZFY	2.37e-05	3	53	2	IPR006794
Domain	Zfx_Zfy_act	ZFX ZFY	2.37e-05	3	53	2	PF04704
Domain	Na/HCO3_transpt	SLC4A8 SLC4A10	7.86e-05	5	53	2	IPR003024
Domain	ANION_EXCHANGER_2	SLC4A8 SLC4A10	1.64e-04	7	53	2	PS00220
Domain	ANION_EXCHANGER_1	SLC4A8 SLC4A10	1.64e-04	7	53	2	PS00219
Domain	Band3_cytoplasmic_dom	SLC4A8 SLC4A10	2.81e-04	9	53	2	IPR013769
Domain	Band_3_cyto	SLC4A8 SLC4A10	2.81e-04	9	53	2	PF07565
Domain	-	SLC4A8 SLC4A10	2.81e-04	9	53	2	3.40.1100.10
Domain	Sp1_fam	SP3 SP4	3.50e-04	10	53	2	IPR030450
Domain	PTrfase/Anion_transptr	SLC4A8 SLC4A10	3.50e-04	10	53	2	IPR016152
Domain	HCO3_cotransp	SLC4A8 SLC4A10	3.50e-04	10	53	2	PF00955
Domain	HCO3_transpt_euk	SLC4A8 SLC4A10	3.50e-04	10	53	2	IPR003020
Domain	HCO3_transpt_C	SLC4A8 SLC4A10	3.50e-04	10	53	2	IPR011531
Domain	AT_hook	SETBP1 ASH1L	2.65e-03	27	53	2	SM00384
Domain	AT_hook_DNA-bd_motif	SETBP1 ASH1L	2.65e-03	27	53	2	IPR017956
Domain	BTB	ZBTB6 ZBTB41 ZBTB11	6.12e-03	131	53	3	PF00651
Domain	BTB	ZBTB6 ZBTB41 ZBTB11	1.06e-02	160	53	3	PS50097
Domain	BTB	ZBTB6 ZBTB41 ZBTB11	1.45e-02	180	53	3	SM00225
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	MEAF6 ZNF775 ZIK1 ZNF680 ZNF569 ZNF718 ZNF549 ZNF667 ZNF506 ZNF799 ZNF692 ZNF169	1.87e-04	1387	38	12	M734
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A8 SLC4A10	3.14e-04	10	38	2	M27335
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A8 SLC4A10	3.14e-04	10	38	2	MM15073
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	SP3 SP4 ZNF775 HIVEP1 ZNF569 ZNF718 ZNF423 ASH1L ZNF506 ZBTB41 POGZ ZNF292	3.20e-09	808	54	12	20412781
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	MEAF6 ORC5 HIVEP1 ZNF680 ERCC6 POGZ ZBTB11 ZNF292 PAPOLG	3.79e-07	608	54	9	36089195
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF22 ZNF680 ZNF569 ZNF718 ZNF799 ZBTB11	3.84e-07	181	54	6	37372979
Pubmed	Differential rates of evolution for the ZFY-related zinc finger genes, Zfy, Zfx, and Zfa in the mouse genus Mus.	ZFX ZFY	2.37e-06	2	54	2	12716983
Pubmed	Intron/exon structure confirms that mouse Zfy1 and Zfy2 are members of the ZFY gene family.	ZFX ZFY	2.37e-06	2	54	2	9126493
Pubmed	Transcription factor Zfx controls BCR-induced proliferation and survival of B lymphocytes.	ZFX ZFY	2.37e-06	2	54	2	19329779
Pubmed	K+-Driven Cl-/HCO3- Exchange Mediated by Slc4a8 and Slc4a10.	SLC4A8 SLC4A10	2.37e-06	2	54	2	38674160
Pubmed	Chromosomal localization of ZFX--a human gene that escapes X inactivation--and its murine homologs.	ZFX ZFY	2.37e-06	2	54	2	1970799
Pubmed	Evolution of the Zfx and Zfy genes: rates and interdependence between the genes.	ZFX ZFY	2.37e-06	2	54	2	8487630
Pubmed	Zfa is an expressed retroposon derived from an alternative transcript of the Zfx gene.	ZFX ZFY	2.37e-06	2	54	2	1691708
Pubmed	The structure of the Zfx gene on the mouse X chromosome.	ZFX ZFY	2.37e-06	2	54	2	8188262
Pubmed	Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes.	SP3 SP4	2.37e-06	2	54	2	1454515
Pubmed	Comparison of human ZFY and ZFX transcripts.	ZFX ZFY	2.37e-06	2	54	2	2308929
Pubmed	Mapping the human ZFX locus to Xp21.3 by in situ hybridization.	ZFX ZFY	2.37e-06	2	54	2	2497060
Pubmed	RNAi as a tool to control the sex ratio of mouse offspring by interrupting Zfx/Zfy genes in the testis.	ZFX ZFY	2.37e-06	2	54	2	28251288
Pubmed	Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY.	ZFX ZFY	2.37e-06	2	54	2	2041734
Pubmed	Gene expression, X-inactivation, and methylation during spermatogenesis: the case of Zfa, Zfx, and Zfy in mice.	ZFX ZFY	2.37e-06	2	54	2	8318216
Pubmed	Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating domain and 13 zinc fingers.	ZFX ZFY	2.37e-06	2	54	2	2105457
Pubmed	Circ_0000520 contributes to triple-negative breast cancer progression through mediating the miR-1296/ZFX axis.	ZFX ZFY	2.37e-06	2	54	2	34324278
Pubmed	Zfx mutation results in small animal size and reduced germ cell number in male and female mice.	ZFX ZFY	2.37e-06	2	54	2	9187153
Pubmed	[Expression of Zfx in mouse testicular spermatogenic cells].	ZFX ZFY	2.37e-06	2	54	2	38602753
Pubmed	Regional assignments of the zinc finger Y-linked gene (ZFY) and related sequences on human and mouse chromosomes.	ZFX ZFY	2.37e-06	2	54	2	2265557
Pubmed	Zfy gene expression patterns are not compatible with a primary role in mouse sex determination.	ZFX ZFY	7.09e-06	3	54	2	2480529
Pubmed	Genetic dissection of mammalian fertility pathways.	ZFX ZFY	7.09e-06	3	54	2	12479614
Pubmed	Analysis of Sp transcription factors in the postmortem brain of chronic schizophrenia: a pilot study of relationship to negative symptoms.	SP3 SP4	7.09e-06	3	54	2	23540600
Pubmed	Isolation of monochromosomal hybrids for mouse chromosomes 3, 6, 10, 12, 14, and 18.	ZFX ZFY	7.09e-06	3	54	2	9060403
Pubmed	Blockade of ZFX Alleviates Hypoxia-Induced Pulmonary Vascular Remodeling by Regulating the YAP Signaling.	ZFX ZFY	7.09e-06	3	54	2	38310188
Pubmed	Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells.	SP3 SP4	7.09e-06	3	54	2	26967243
Pubmed	Curcumin decreases specificity protein expression in bladder cancer cells.	SP3 SP4	7.09e-06	3	54	2	18593936
Pubmed	Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells.	SP3 SP4	7.09e-06	3	54	2	21919647
Pubmed	Transcriptional regulation of the mouse gene encoding the alpha-4 subunit of the GABAA receptor.	SP3 SP4	7.09e-06	3	54	2	15265862
Pubmed	O-GlcNAc modification of Sp3 and Sp4 transcription factors negatively regulates their transcriptional activities.	SP3 SP4	7.09e-06	3	54	2	26431879
Pubmed	YAC clone contigs surrounding the Zfx and Pola loci on the mouse X chromosome.	ZFX ZFY	7.09e-06	3	54	2	8406471
Pubmed	X chromosome genes and premature ovarian failure.	ZFX ZFY	7.09e-06	3	54	2	11299520
Pubmed	Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene.	SP3 SP4	7.09e-06	3	54	2	11532028
Pubmed	Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters.	ZFX ZFY	7.09e-06	3	54	2	32406922
Pubmed	Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3.	SP3 SP4	7.09e-06	3	54	2	7559627
Pubmed	A census of human transcription factors: function, expression and evolution.	SP3 SP4 CTCFL ZNF22 HIVEP1 SETBP1 ASH1L ZFX ZFY	1.00e-05	908	54	9	19274049
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	SP3 ZBTB6 HIVEP1 POGZ ZNF692 ZFX ZFY ZNF292	1.30e-05	709	54	8	22988430
Pubmed	Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx.	SP3 SP4	1.42e-05	4	54	2	15781457
Pubmed	Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia.	SP3 SP4	1.42e-05	4	54	2	27889927
Pubmed	ZFX controls propagation and prevents differentiation of acute T-lymphoblastic and myeloid leukemia.	ZFX ZFY	1.42e-05	4	54	2	24485662
Pubmed	Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins.	SP3 SP4	1.42e-05	4	54	2	16574784
Pubmed	Zfx controls the self-renewal of embryonic and hematopoietic stem cells.	ZFX ZFY	1.42e-05	4	54	2	17448993
Pubmed	Immunocytochemical identification of electroneutral Na⁺-coupled HCO₃⁻ transporters in freshly dissociated mouse medullary raphé neurons.	SLC4A8 SLC4A10	2.36e-05	5	54	2	23500099
Pubmed	The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (Chr 17) and Zfp161-rs1 (X Chr).	ZFX ZFY	2.36e-05	5	54	2	9244432
Pubmed	Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway.	ZFX ZFY	2.36e-05	5	54	2	25164012
Pubmed	Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors.	SP3 SP4	2.36e-05	5	54	2	12560508
Pubmed	Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation.	SP3 SP4	2.36e-05	5	54	2	20538607
Pubmed	Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter.	SP3 SP4	2.36e-05	5	54	2	10547281
Pubmed	Chromosome mapping and expression of a putative testis-determining gene in mouse.	ZFX ZFY	2.36e-05	5	54	2	2563174
Pubmed	MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis.	ZFX ZFY	2.36e-05	5	54	2	9721210
Pubmed	Maintenance of X inactivation of the Rps4, Zfx, and Ube1 genes in a mouse in vitro system.	ZFX ZFY	2.36e-05	5	54	2	7681608
Pubmed	Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases.	ASH1L ZNF292	2.36e-05	5	54	2	28191889
Pubmed	Sequence and expression of murine cDNAs encoding Xlr3a and Xlr3b, defining a new X-linked lymphocyte-regulated Xlr gene subfamily.	ZFX ZFY	3.54e-05	6	54	2	7821804
Pubmed	Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1.	SP3 SP4	3.54e-05	6	54	2	7800480
Pubmed	Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells.	SP3 SP4	3.54e-05	6	54	2	16201967
Pubmed	An evaluation of the inactive mouse X chromosome in somatic cell hybrids.	ZFX ZFY	4.94e-05	7	54	2	8460399
Pubmed	Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.	ZFX ZFY	4.94e-05	7	54	2	8378320
Pubmed	Embryonic growth and the evolution of the mammalian Y chromosome. II. Suppression of selfish Y-linked growth factors may explain escape from X-inactivation and rapid evolution of Sry.	ZFX ZFY	4.94e-05	7	54	2	7928394
Pubmed	POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1.	SP3 SP4	4.94e-05	7	54	2	12004059
Pubmed	The Dazh gene is expressed in male and female embryonic gonads before germ cell sex differentiation.	ZFX ZFY	4.94e-05	7	54	2	9588208
Pubmed	Genetic mapping in the mouse of Kif4, a gene encoding a kinesin-like motor protein.	ZFX ZFY	4.94e-05	7	54	2	9196009
Pubmed	Genome-wide association study identifies loci affecting blood copper, selenium and zinc.	USP22 POGZ ZXDB	6.20e-05	49	54	3	23720494
Pubmed	Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome.	ZFX ZFY	6.59e-05	8	54	2	2034279
Pubmed	Genetic mapping in the region of the mouse X-inactivation center.	ZFX ZFY	6.59e-05	8	54	2	1974879
Pubmed	High-density molecular map of the central span of the mouse X chromosome.	ZFX ZFY	6.59e-05	8	54	2	1675191
Pubmed	exma: an X-linked insertional mutation that disrupts forebrain and eye development.	ZFX ZFY	8.46e-05	9	54	2	11956759
Pubmed	Structure, chromosomal location, and expression pattern of three mouse genes homologous to the human MAGE genes.	ZFX ZFY	8.46e-05	9	54	2	7590750
Pubmed	Cloning and characterization of a new human Xq13 gene, encoding a putative helicase.	ZFX ZFY	8.46e-05	9	54	2	7874112
Pubmed	The mouse genes encoding the third pair of beta-type proteasome subunits regulated reciprocally by IFN-gamma: structural comparison, chromosomal localization, and analysis of the promoter.	ZFX ZFY	8.46e-05	9	54	2	9300697
Pubmed	Praja1, a novel gene encoding a RING-H2 motif in mouse development.	ZFX ZFY	8.46e-05	9	54	2	9393880
Pubmed	Genetic and molecular evidence of an X-chromosome deletion spanning the tabby (Ta) and testicular feminization (Tfm) loci in the mouse.	ZFX ZFY	1.06e-04	10	54	2	2055107
Pubmed	Mapping of the phosphorylase kinase alpha subunit gene on the mouse X chromosome.	ZFX ZFY	1.06e-04	10	54	2	1973380
Pubmed	Characterization of a murine gene expressed from the inactive X chromosome.	ZFX ZFY	1.29e-04	11	54	2	2034278
Pubmed	ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.	ZBTB6 ZBTB41 ZBTB11	1.32e-04	63	54	3	34351428
Pubmed	Zinc finger protein genes in the mouse genome.	ZFX ZFY	1.55e-04	12	54	2	1797234
Pubmed	The construction of human somatic cell hybrids containing portions of the mouse X chromosome and their use to generate DNA probes via interspersed repetitive sequence polymerase chain reaction.	ZFX ZFY	1.55e-04	12	54	2	1916827
Pubmed	Identification and genetic mapping of differentially expressed genes in mice differing at the If1 interferon regulatory locus.	HIVEP1 ZFX ZFY	1.58e-04	67	54	3	10441734
Pubmed	The murine interleukin-2 receptor gamma chain gene: organization, chromosomal localization and expression in the adult thymus.	ZFX ZFY	1.83e-04	13	54	2	7805729
Pubmed	Localization of murine X and autosomal sequences homologous to the human Y located testis-determining region.	ZFX ZFY	1.83e-04	13	54	2	2721933
Pubmed	Rps4 maps near the inactivation center on the mouse X chromosome.	ZFX ZFY	1.83e-04	13	54	2	1740345
Pubmed	XIST and the mapping of the X chromosome inactivation centre.	ZFX ZFY	1.83e-04	13	54	2	1772416
Pubmed	Mapping of a liver phosphorylase kinase alpha-subunit gene on the mouse X chromosome.	ZFX ZFY	2.13e-04	14	54	2	8432533
Pubmed	Interaction network of human early embryonic transcription factors.	MEAF6 TET2 HIVEP1 ZNF423 POGZ	2.15e-04	351	54	5	38297188
Pubmed	Molecular phylogenetics and the origins of placental mammals.	ZFX ZFY	2.45e-04	15	54	2	11214319
Pubmed	Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse.	ZFX ZFY	2.45e-04	15	54	2	11353388
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	ZFX ZFY	2.45e-04	15	54	2	14762062
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	TET2 ORC5 SP4 HIVEP1 ZNF680 USP22 POGZ ZNF292	2.84e-04	1103	54	8	34189442
Pubmed	Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation.	ZFX ZFY	3.17e-04	17	54	2	19571810
Pubmed	Characterization and mapping of human genes encoding zinc finger proteins.	ZNF22 ZNF569	5.36e-04	22	54	2	1946370
Pubmed	Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes.	ZNF22 ZNF569	5.36e-04	22	54	2	1505991
Pubmed	A germline-specific class of small RNAs binds mammalian Piwi proteins.	ZNF132 USP22 ASH1L ANKRD12 ZNF169	6.66e-04	450	54	5	16751776
Pubmed	Mammalian SP/KLF transcription factors: bring in the family.	SP3 SP4	6.94e-04	25	54	2	15820306
Pubmed	Positioning of five genes (CASK, ARX, SAT, IMAGE cDNAs 248928 and 253949) from the human X chromosome short arm with respect to evolutionary breakpoints on the mouse X chromosome.	ZFX ZFY	7.51e-04	26	54	2	10920247
Pubmed	Gene knockouts that cause female infertility: search for novel contraceptive targets.	ZFX ZFY	8.72e-04	28	54	2	15970507
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF718 ZNF506	9.35e-04	29	54	2	14563677
Pubmed	Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.	ORC5 USP22 POGZ	9.61e-04	124	54	3	20850016
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ZBTB6 ZNF569 FARP1 POP1 ASH1L ZBTB41 ANKRD12	1.38e-03	1084	54	7	11544199
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	ASH1L POGZ ZBTB11 ZFX ZFY	1.41e-03	533	54	5	30554943
Interaction	ZNF710 interactions	CTCFL ZNF423 ZNF667 POGZ	1.11e-06	30	53	4	int:ZNF710
Interaction	SP4 interactions	SP3 SP4 HIVEP1 POGZ	6.41e-06	46	53	4	int:SP4
Interaction	H3-3A interactions	MEAF6 ORC5 HIVEP1 ERCC6 HPF1 ASH1L POGZ ZBTB11 ZNF292 PAPOLG	2.17e-05	749	53	10	int:H3-3A
Interaction	ZSCAN10 interactions	CTCFL ZNF423 ZNF667	4.28e-05	26	53	3	int:ZSCAN10
Interaction	RBAK interactions	CTCFL ZNF423 ZNF667 ZNF169	6.10e-05	81	53	4	int:RBAK
Interaction	ZFP3 interactions	CTCFL ZNF423 ZNF667	6.63e-05	30	53	3	int:ZFP3
Interaction	ZNF382 interactions	CTCFL ZNF423 ZNF667	8.86e-05	33	53	3	int:ZNF382
Interaction	ZNF513 interactions	CTCFL ZNF423 ZNF667	9.70e-05	34	53	3	int:ZNF513
Interaction	ZNF652 interactions	CTCFL ZNF423 ZNF667	1.06e-04	35	53	3	int:ZNF652
Interaction	ZFP28 interactions	CTCFL ZNF423 ZNF667	1.25e-04	37	53	3	int:ZFP28
Cytoband	19q13.43	ZIK1 ZNF549 ZNF667	1.52e-04	87	54	3	19q13.43
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF132 SP3 SP4 CTCFL ZNF22 ZBTB6 ZNF775 ZIK1 HIVEP1 ZNF680 ZNF569 ZNF718 ZNF366 ZNF549 ZNF423 ZNF667 ZNF506 ZNF799 ZBTB41 ZNF81 ZBTB11 ZNF692 ZNF169 ZFX ZFY ZXDB ZNF292	1.34e-27	718	43	27	28
GeneFamily	Zinc fingers C2H2-type\|Sp transcription factors	SP3 SP4	1.97e-04	9	43	2	755
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB6 ZBTB41 ZBTB11	3.96e-03	134	43	3	861
Coexpression	GSE2706_UNSTIM_VS_2H_LPS_DC_UP	CACNA2D4 ZIK1 ZBTB41 ZNF692 PAPOLG	4.45e-05	197	52	5	M4695
Coexpression	BLANCO_MELO_COVID19_SARS_COV_2_INFECTION_A594_ACE2_EXPRESSING_CELLS_RUXOLITINIB_UP	TET2 SLC26A3 ZBTB6 HIVEP1 PDGFB ZNF799 ANKRD12	4.69e-05	486	52	7	M34018
Coexpression	GSE21546_WT_VS_SAP1A_KO_ANTI_CD3_STIM_DP_THYMOCYTES_DN	ORC5 ZNF569 MCM9 ASH1L ANKRD12	4.78e-05	200	52	5	M7532
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ Genital tubercle M_emap-6706_k-means-cluster#4_top-relative-expression-ranked_500	SP3 ZIK1 MCM9 ZBTB41 ZXDB ZNF292	3.39e-05	247	53	6	gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle M_500_k4
ToppCell	ILEUM-non-inflamed-(3)_MNP-(3)_moDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ASH1L NKTR ANKRD12 ZNF292 PAPOLG	5.77e-07	135	53	5	b7a792a7c0c22d8b703509f134115f0e394d7de0
ToppCell	droplet-Lung-nan-18m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ORC5 HIVEP1 SLC4A8 MCM9 ZNF692	2.13e-06	176	53	5	24b2e94ee5defcefb64a1f2447a2cc71b015b0fd
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 ASH1L NKTR ANKRD12 ZNF292	3.98e-06	200	53	5	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_D\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	SP3 SLC4A8 ZNF718 ZNF549	2.90e-05	148	53	4	10dcbdb47cac908648d9d652c8095b536db19b8a
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_memory_T_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ZNF569 NKTR ANKRD12 ZFY	3.31e-05	153	53	4	64d0f37d7af9b76234f683379e3689771f71fe70
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	MCM9 ZNF169 ZXDB PAPOLG	3.94e-05	160	53	4	8aaf6ac4f33ea291387fdbf9ff1a91d559391774
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	ASH1L ZNF506 NKTR ANKRD12	4.13e-05	162	53	4	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_D\|367C / Donor, Lineage, Cell class and subclass (all cells)	SP3 SLC4A8 ZNF718 ZNF549	5.22e-05	172	53	4	6379ae0aca9007c3a8a87e3330908fc90961ad3f
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l44\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TET2 ZBTB6 MCM9 POP1	5.34e-05	173	53	4	b6bb2a136a40f0946bbcde8d5972d3f059d080c7
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL36B SETBP1 CNKSR2 ANKRD12	5.58e-05	175	53	4	65571d775d26a40e979dbf290a8e4320c0d9fb3f
ToppCell	droplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ORC5 HIVEP1 SLC4A8 MCM9	5.83e-05	177	53	4	f360f7099570d248531897b96e0de282e58f59e9
ToppCell	droplet-Fat-Bat-18m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF22 SLC4A8 PDGFB MCM9	6.09e-05	179	53	4	9863ab3ceb160a4b1d9790033a4ac48845863d65
ToppCell	droplet-Fat-Bat-18m-Endothelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF22 SLC4A8 PDGFB MCM9	6.09e-05	179	53	4	dfe110add7228cd834b35916cbcc849769a01bb9
ToppCell	droplet-Fat-Bat-18m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF22 SLC4A8 PDGFB MCM9	6.09e-05	179	53	4	e6224864eb76a2e9c1fc0c61513d9e936bb5c72c
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_neural-B\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CTCFL SETBP1 CNKSR2 ZNF692	6.78e-05	184	53	4	cd2919dc8e90d03f57eb43f59f7da9bcd676496e
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	ASH1L NKTR ANKRD12 ZBTB11	7.37e-05	188	53	4	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	cellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	HIVEP1 ZNF423 SETBP1 PAPOLG	7.52e-05	189	53	4	bccb3481ffed597c845fe860da658505316105b5
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	MCM9 NKTR ZNF169 ZNF292	7.83e-05	191	53	4	9454f642c3621370fa23640b631301346b300950
ToppCell	H1299-infected\|H1299 / Cell line, Condition and Strain	ASH1L NKTR ANKRD12 ZNF292	7.99e-05	192	53	4	9cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	NKTR ZNF81 ZNF169 ZFY	8.32e-05	194	53	4	6be74e4ba631b0c46cef2c580553f4c1ed29579e
ToppCell	mild-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HIVEP1 ZNF680 POGZ ZBTB11	8.49e-05	195	53	4	1e5f1967bcc898318f4e970b844b4a944eb168e5
ToppCell	COVID-19-lung-Capillary_2\|lung / Disease (COVID-19 only), tissue and cell type	SLC26A3 PDGFB ZNF366 ZNF423	9.18e-05	199	53	4	793ce71b78a68033ef4419ed571e1dd86b40124f
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ASH1L NKTR ANKRD12 ZNF292	9.18e-05	199	53	4	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	USP22 PDGFB ASH1L NKTR	9.36e-05	200	53	4	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	USP22 PDGFB ZNF366 NKTR	9.36e-05	200	53	4	a2b9d1cd291d17abddc3ee2e242121412c864b8b
Drug	vinylene	ZNF132 SP4 ZNF22 ZNF569 ZNF423 ZNF667 ZNF81 ZFX ZFY	4.90e-09	245	53	9	CID000006326
Drug	Decamethonium bromide [541-22-0]; Up 200; 9.6uM; MCF7; HT_HG-U133A	SP3 ZBTB6 ERCC6 PDGFB FARP1 ZFX	6.55e-06	198	53	6	7353_UP
Disease	Neurodevelopmental Disorders	SETBP1 ASH1L POGZ ZNF292	1.49e-05	93	47	4	C1535926
Disease	Intellectual Disability	SETBP1 ASH1L SLC4A10 POGZ ZBTB11 ZNF292	7.42e-05	447	47	6	C3714756
Disease	Colorectal Carcinoma	TET2 ERCC6 ZNF569 SETBP1 CNKSR2 IQUB ZNF292	1.15e-04	702	47	7	C0009402
Disease	Thrombocythemia, Essential	TET2 PDGFB	1.62e-04	12	47	2	C0040028
Disease	anemia (implicated_via_orthology)	SLC4A8 SLC4A10	2.57e-04	15	47	2	DOID:2355 (implicated_via_orthology)
Disease	Mental Retardation, X-Linked 1	CNKSR2 ZNF81	1.19e-03	32	47	2	C2931498
Disease	neutrophil count	TET2 HIVEP1 PDGFB ZNF366 ZNF423 ASH1L POGZ ZNF292	1.40e-03	1382	47	8	EFO_0004833
Disease	Malignant neoplasm of breast	ZNF22 ERCC6 ZNF569 ZNF366 FARP1 SETBP1 POP1	1.46e-03	1074	47	7	C0006142
Disease	balding measurement	TET2 SP3 ZNF549 ZNF423 SETBP1 CNKSR2	1.54e-03	792	47	6	EFO_0007825

Protein segments in the cluster

Peptide	Gene	Start	Entry
LHLQKNKSQKEKHRH	nan	61	A8MVM7
HLLLNPAKYHKKKHK	ASH1L	1431	Q9NR48
HQKTHKNEKRFKCKH	CTCFL	476	Q8NI51
FHKHLNGKKSVKHSK	ACOT6	406	Q3I5F7
KHKEKSKHQKDFHLE	ANKRD12	601	Q6UB98
NNFYKHKSKTKHHSV	ERCC6	1176	Q03468
HKTKKKSTGLNFNLH	HPF1	91	Q9NWY4
LNSHHNKKHGVFSKL	LEXM	271	Q3ZCV2
GKHRKFKHTHDKTAL	PDGFB	221	P01127
AVHQKKEHSKNKCHK	POP1	166	Q99575
KIEATHVKKKQLHHY	PAPOLG	481	Q9BWT3
KSSFQHHHLRKKDKD	IL36B	136	Q9NZH7
HKKVQFERKHSKIHS	FARP1	356	Q9Y4F1
EAKSVFHHSHKHKKQ	CACNA2D4	991	Q7Z3S7
SFIHKIKHKHILAKN	IQUB	736	Q8NA54
SGSHHSSHKKRKNKN	MEAF6	161	Q9HAF1
KQKSKLIHSFEDHSH	MCM9	926	Q9NXL9
HLSKHVKTHQNKKGG	SP4	721	Q02446
KHKHGSKENLKREHT	NKTR	976	P30414
HAHHASKVNQHKQKF	SPATA31A6	1221	Q5VVP1
HHGKIKKTNFLKKHE	ORC5	331	O43913
KKTNFLKKHEKTSNH	ORC5	336	O43913
DKIEHKLQHHKTFRK	POGZ	661	Q7Z3K3
KKTGRHHKTFLDHLK	SLC26A3	26	P40879
LLKKHHHQNEKKRNN	SLC4A8	216	Q2Y0W8
HTFQQSSLQHKSKKK	CNKSR2	536	Q8WXI2
HKKIHNGKKTHKYNK	ZNF667	271	Q5HYK9
SHSSKLRKHQKFHTE	ZNF132	301	P52740
TFAKKHQLKVHLLTH	ZXDB	281	P98169
AFKQSSHLNKHKKIH	ZNF718	431	Q3SXZ3
SHLNKHKKIHTVDKP	ZNF718	436	Q3SXZ3
TKKHIHEHAKAKRHN	USP22	86	Q9UPT9
KHGLKLHQSLHQSQK	ZBTB11	691	O95625
AFISKQTLLKHHKIH	ZNF549	481	Q6P9A3
LAKHIKTHQNKKGIH	SP3	696	Q02447
VHRKKHSNETEFHKK	ZBTB41	406	Q5SVQ8
HASKKTLAKHVKRFH	ZBTB41	431	Q5SVQ8
NHHQHQKHHSAKKSL	ZIK1	131	Q3SY52
ALMKQHHHQNQKKLT	SLC4A10	216	Q6U841
HIFNKHNDKHKAHLI	ZNF292	2276	O60281
RFSQKQHLLKHQKTH	ZNF775	171	Q96BV0
SNLNKHKKIHTGEKH	ZNF840P	486	A6NDX5
LSKHKKIHTGEKHFV	ZNF840P	676	A6NDX5
SSLHRHKKTHWKKTH	ZNF799	601	Q96GE5
RKAFSHKKNFITHQK	ZNF569	416	Q5MCW4
HKKNFITHQKIHTRE	ZNF569	421	Q5MCW4
LKQHSLTHKGVKEHK	ZNF366	436	Q8N895
FQHQKIHTGKKSHKC	ZNF22	71	P17026
NKKISLHNHLESHKL	ZFX	466	P17010
SLQSHMQAHKKNKEH	ZNF423	236	Q2M1K9
SEKNKHKEKQKHQHS	SETBP1	1201	Q9Y6X0
HKEKQKHQHSEAGHK	SETBP1	1206	Q9Y6X0
HLKQFHAKSLFDHKA	TET2	1031	Q6N021
KVFHKFSNSNSHKKR	ZNF680	161	Q8NEM1
KSNLYKHKKSHAHTI	HIVEP1	446	P15822
VKFLHKFSNSNKHKI	ZNF506	151	Q5JVG8
LSKKSSLFSHQKHHV	ZNF169	221	Q14929
EVHPKQHAHKQSFAK	TWF1	311	Q12792
NFKKHLKEHMKLHSD	ZNF692	371	Q9BU19
GKSFKHNLDLHIHNK	ZNF81	196	P51508
TNKKISLHNHLESHK	ZFY	461	P08048
FKHKSALKKHLTSVH	ZBTB6	391	Q15916