| MousePheno | abnormal postnatal growth | DLG5 HAP1 CWC27 KDM3B KIF4A FOXN3 AK7 NLRP3 CHRNE NEDD4 DST PTPRS RAPGEF3 KCNMA1 KIF4B EIF2AK3 | 1.97e-05 | 907 | 75 | 16 | MP:0001731 |
| MousePheno | postnatal growth retardation | DLG5 HAP1 CWC27 KDM3B KIF4A FOXN3 AK7 NLRP3 CHRNE NEDD4 DST PTPRS RAPGEF3 KIF4B EIF2AK3 | 5.63e-05 | 881 | 75 | 15 | MP:0001732 |
| MousePheno | increased dendritic spine number | KIF4A KIF4B | 8.49e-05 | 3 | 75 | 2 | MP:0021019 |
| MousePheno | slow postnatal weight gain | HAP1 KIF4A NLRP3 CHRNE DST RAPGEF3 KIF4B | 1.12e-04 | 205 | 75 | 7 | MP:0008489 |
| Domain | PAH | SIN3B GON4L | 7.49e-05 | 3 | 94 | 2 | IPR003822 |
| Domain | - | SIN3B GON4L | 7.49e-05 | 3 | 94 | 2 | 1.20.1160.11 |
| Domain | PAH | SIN3B GON4L | 7.49e-05 | 3 | 94 | 2 | PS51477 |
| Domain | PAH | SIN3B GON4L | 7.49e-05 | 3 | 94 | 2 | PF02671 |
| Domain | Spectrin/alpha-actinin | AKAP6 SPTBN4 DST | 5.51e-04 | 32 | 94 | 3 | IPR018159 |
| Domain | SPEC | AKAP6 SPTBN4 DST | 5.51e-04 | 32 | 94 | 3 | SM00150 |
| Domain | - | MYD88 DLG5 NLRP3 UNC5D | 1.25e-03 | 93 | 94 | 4 | 1.10.533.10 |
| Domain | DEATH-like_dom | MYD88 DLG5 NLRP3 UNC5D | 1.57e-03 | 99 | 94 | 4 | IPR011029 |
| Domain | ARM-like | GPRASP1 RANBP6 WDFY4 RSPRY1 PPP4R3A UTP20 | 2.43e-03 | 270 | 94 | 6 | IPR011989 |
| Domain | P-loop_NTPase | RAB23 DDX19B DDX19A DLG5 KIF4A ABCC11 AK7 NLRP3 GSPT2 EIF5B KIF4B | 3.52e-03 | 848 | 94 | 11 | IPR027417 |
| Domain | EFTu-like_2 | GSPT2 EIF5B | 3.64e-03 | 18 | 94 | 2 | IPR004161 |
| Domain | GTP_EFTU_D2 | GSPT2 EIF5B | 3.64e-03 | 18 | 94 | 2 | PF03144 |
| Domain | G_TR_2 | GSPT2 EIF5B | 3.64e-03 | 18 | 94 | 2 | PS51722 |
| Domain | TF_GTP-bd_dom | GSPT2 EIF5B | 4.05e-03 | 19 | 94 | 2 | IPR000795 |
| Domain | SH3_domain | DLG5 DST MIA2 SH3D19 HCLS1 | 5.09e-03 | 220 | 94 | 5 | IPR001452 |
| Domain | Cupredoxin | PRPF8 PKHD1L1 | 5.42e-03 | 22 | 94 | 2 | IPR008972 |
| Domain | Actinin_actin-bd_CS | SPTBN4 DST | 5.92e-03 | 23 | 94 | 2 | IPR001589 |
| Domain | Spectrin | SPTBN4 DST | 5.92e-03 | 23 | 94 | 2 | PF00435 |
| Domain | ACTININ_2 | SPTBN4 DST | 5.92e-03 | 23 | 94 | 2 | PS00020 |
| Domain | ACTININ_1 | SPTBN4 DST | 5.92e-03 | 23 | 94 | 2 | PS00019 |
| Domain | Znf_FYVE_PHD | PHF23 ZFYVE28 TAF3 SYTL4 | 6.50e-03 | 147 | 94 | 4 | IPR011011 |
| Domain | ARM-type_fold | GPRASP1 RANBP6 WDFY4 RSPRY1 PPP4R3A UTP20 | 7.32e-03 | 339 | 94 | 6 | IPR016024 |
| Domain | HECT | NEDD4L NEDD4 | 8.11e-03 | 27 | 94 | 2 | PF00632 |
| Pubmed | Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. | GPRASP1 SIN3B NEDD4L KIF4A NEDD4 SPTBN4 DST ZKSCAN1 UBE2V2 PTPRS SH3D19 KCNMA1 KIF4B EPHA4 | 5.35e-07 | 963 | 98 | 14 | 28671696 |
| Pubmed | Ndfip1 expression in developing neurons indicates a role for protein ubiquitination by Nedd4 E3 ligases during cortical development. | NEDD4L MAP2 NEDD4 | 1.20e-06 | 8 | 98 | 3 | 24036464 |
| Pubmed | N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective. | SART3 SIN3B RPS6 KDM3B KIF4A PRPF8 PPP4R3A DST R3HCC1L SH3D19 USP7 EIF5B EIF3A | 2.28e-06 | 934 | 98 | 13 | 33916271 |
| Pubmed | Human transcription factor protein interaction networks. | SIN3B PHF23 DIABLO SCAF8 BCORL1 GON4L TNRC6C GTF3C3 MFAP1 TAF3 DST ZFHX4 ZKSCAN1 USP7 GMEB1 EIF3A | 2.39e-06 | 1429 | 98 | 16 | 35140242 |
| Pubmed | Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. | AKAP6 KDM3B TNRC6C DSCAML1 PHLDB1 DST ARHGEF10 | 3.63e-06 | 225 | 98 | 7 | 12168954 |
| Pubmed | Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains. | SART3 DLG5 MAP2 PRPF8 CCDC61 GTF3C3 MFAP1 CACTIN R3HCC1L CEP89 ARHGEF10 EIF5B CENPV IFT122 EIF2AK3 MAST3 | 3.98e-06 | 1487 | 98 | 16 | 33957083 |
| Pubmed | Defining the human deubiquitinating enzyme interaction landscape. | DDX19B SART3 GPRASP1 NEDD4L DIABLO COPRS KDM3B PRPF8 KLHL22 ARHGEF10 SYTL4 USP7 EIF3A | 5.04e-06 | 1005 | 98 | 13 | 19615732 |
| Pubmed | MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis. | SIN3B BCORL1 KDM3B PRPF8 GTF3C3 MFAP1 CACTIN USP7 | 5.51e-06 | 339 | 98 | 8 | 30415952 |
| Pubmed | Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer. | SART3 PHF23 KDM3B KIF4A PRPF8 GTF3C3 PPP4R3A MFAP1 CACTIN TAF3 USP7 EIF5B EIF3A | 5.55e-06 | 1014 | 98 | 13 | 32416067 |
| Pubmed | Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. | SART3 MAGEA4 UBR1 DDX19A RPS6 KIF4A PRPF8 GTF3C3 MFAP1 PHLDB1 DST USP7 EIF5B UTP20 EIF3A | 5.78e-06 | 1353 | 98 | 15 | 29467282 |
| Pubmed | KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway. | KIF4A KIF4B | 7.86e-06 | 2 | 98 | 2 | 36482480 |
| Pubmed | The multiple functions of kinesin-4 family motor protein KIF4 and its clinical potential. | KIF4A KIF4B | 7.86e-06 | 2 | 98 | 2 | 30081192 |
| Pubmed | Chromokinesin Kif4 promotes proper anaphase in mouse oocyte meiosis. | KIF4A KIF4B | 7.86e-06 | 2 | 98 | 2 | 31067151 |
| Pubmed | A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel. | NEDD4L NEDD4 | 7.86e-06 | 2 | 98 | 2 | 11149908 |
| Pubmed | Cellular motor protein KIF-4 associates with retroviral Gag. | KIF4A KIF4B | 7.86e-06 | 2 | 98 | 2 | 10559369 |
| Pubmed | Dietary sodium modulates nephropathy in Nedd4-2-deficient mice. | NEDD4L NEDD4 | 7.86e-06 | 2 | 98 | 2 | 31802037 |
| Pubmed | KIF4 regulates midzone length during cytokinesis. | KIF4A KIF4B | 7.86e-06 | 2 | 98 | 2 | 21565503 |
| Pubmed | A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally. | KIF4A KIF4B | 7.86e-06 | 2 | 98 | 2 | 7929562 |
| Pubmed | Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2. | NEDD4L NEDD4 | 7.86e-06 | 2 | 98 | 2 | 37962894 |
| Pubmed | USP7 Promotes deubiquitination and stabilization of MyD88 to enhance immune responses. | MYD88 USP7 | 7.86e-06 | 2 | 98 | 2 | 36032091 |
| Pubmed | Whole genome expression microarray reveals novel roles for Kif4 in monocyte/macrophage cells. | KIF4A KIF4B | 7.86e-06 | 2 | 98 | 2 | 31486502 |
| Pubmed | Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na(+) channel regulation. | NEDD4L NEDD4 | 7.86e-06 | 2 | 98 | 2 | 11502596 |
| Pubmed | Analysis of WDFY4 rs7097397 and PHLDB1 rs7389 polymorphisms in Chinese patients with systemic lupus erythematosus. | WDFY4 PHLDB1 | 7.86e-06 | 2 | 98 | 2 | 35188604 |
| Pubmed | Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization. | KIF4A KIF4B | 7.86e-06 | 2 | 98 | 2 | 10773663 |
| Pubmed | USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway. | NEDD4L USP7 | 7.86e-06 | 2 | 98 | 2 | 33106424 |
| Pubmed | Missense Pathogenic variants in KIF4A Affect Dental Morphogenesis Resulting in X-linked Taurodontism, Microdontia and Dens-Invaginatus. | KIF4A KIF4B | 7.86e-06 | 2 | 98 | 2 | 31616463 |
| Pubmed | Nedd4 and Nedd4-2: ubiquitin ligases at work in the neuron. | NEDD4L NEDD4 | 7.86e-06 | 2 | 98 | 2 | 23262292 |
| Pubmed | Kif4 regulates the expression of VEGFR1 through the PI3K/Akt signaling pathway in RAW264.7 monocytes/macrophages. | KIF4A KIF4B | 7.86e-06 | 2 | 98 | 2 | 28350061 |
| Pubmed | Down-regulating destruction: phosphorylation regulates the E3 ubiquitin ligase Nedd4-2. | NEDD4L NEDD4 | 7.86e-06 | 2 | 98 | 2 | 19602703 |
| Pubmed | Kif4 interacts with EB1 and stabilizes microtubules downstream of Rho-mDia in migrating fibroblasts. | KIF4A KIF4B | 7.86e-06 | 2 | 98 | 2 | 24658398 |
| Pubmed | Hemorrhagic shock augments Nlrp3 inflammasome activation in the lung through impaired pyrin induction. | MYD88 NLRP3 | 7.86e-06 | 2 | 98 | 2 | 23585683 |
| Pubmed | Structural basis for the ATP-induced isomerization of kinesin. | KIF4A KIF4B | 7.86e-06 | 2 | 98 | 2 | 23500491 |
| Pubmed | Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88. | MYD88 NLRP3 | 7.86e-06 | 2 | 98 | 2 | 21690334 |
| Pubmed | Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein. | KIF4A KIF4B | 7.86e-06 | 2 | 98 | 2 | 9658142 |
| Pubmed | DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKKε-IRF3 Interactions and Promoting TBK1 and IKKε Degradation. | DDX19B DDX19A | 7.86e-06 | 2 | 98 | 2 | 30699353 |
| Pubmed | The in vivo Interaction Landscape of Histones H3.1 and H3.3. | SIN3B CWC27 BCORL1 KDM3B KIF4A GTF3C3 CACTIN TAF3 USP7 CENPV | 8.73e-06 | 608 | 98 | 10 | 36089195 |
| Pubmed | Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. | GON4L TNRC6C WDFY4 SPTBN4 ZFYVE28 | 1.02e-05 | 101 | 98 | 5 | 10997877 |
| Pubmed | Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development. | MAP2 RPS6 KLHL22 | 1.18e-05 | 16 | 98 | 3 | 36440598 |
| Pubmed | Large-scale characterization of HeLa cell nuclear phosphoproteins. | UBR1 SCAF8 KDM3B PPP4R3A MFAP1 CACTIN TAF3 USP7 EIF5B UTP20 UNC5D | 1.19e-05 | 774 | 98 | 11 | 15302935 |
| Pubmed | In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker. | SART3 IL12RB1 CWC27 RPS6 PRPF8 SPTBN4 MFAP1 DST GSPT2 MIA2 EIF5B IFT122 EIF3A HCLS1 EPHA4 | 1.23e-05 | 1442 | 98 | 15 | 35575683 |
| Pubmed | Wrapping up the bad news: HIV assembly and release. | NEDD4L KIF4A NEDD4 | 1.72e-05 | 18 | 98 | 3 | 23305486 |
| Pubmed | Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain. | NEDD4L NEDD4 | 2.35e-05 | 3 | 98 | 2 | 18498246 |
| Pubmed | Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway. | NEDD4L NEDD4 | 2.35e-05 | 3 | 98 | 2 | 21852580 |
| Pubmed | Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination. | NEDD4L NEDD4 | 2.35e-05 | 3 | 98 | 2 | 15217910 |
| Pubmed | Role of caspase-1 in regulation of triglyceride metabolism. | MYD88 NLRP3 | 2.35e-05 | 3 | 98 | 2 | 23487794 |
| Pubmed | Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein. | NEDD4L NEDD4 | 2.35e-05 | 3 | 98 | 2 | 12050153 |
| Pubmed | Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation. | NEDD4L NEDD4 | 2.35e-05 | 3 | 98 | 2 | 20730100 |
| Pubmed | Tumor formation via loss of a molecular motor protein. | KIF4A KIF4B | 2.35e-05 | 3 | 98 | 2 | 16890532 |
| Pubmed | KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons. | KIF4A KIF4B | 2.35e-05 | 3 | 98 | 2 | 19158085 |
| Pubmed | Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein. | KIF4A KIF4B | 2.35e-05 | 3 | 98 | 2 | 10978527 |
| Pubmed | Characterization of the interactions between Nedd4-2, ENaC, and sgk-1 using surface plasmon resonance. | NEDD4L NEDD4 | 2.35e-05 | 3 | 98 | 2 | 12729930 |
| Pubmed | NEDD4 ameliorates myocardial reperfusion injury by preventing macrophages pyroptosis. | NLRP3 NEDD4 | 2.35e-05 | 3 | 98 | 2 | 36732831 |
| Pubmed | The high-affinity choline transporter CHT1 is regulated by the ubiquitin ligase Nedd4-2. | NEDD4L NEDD4 | 2.35e-05 | 3 | 98 | 2 | 22361880 |
| Pubmed | Differential expression of NLRP3 among hematopoietic cells. | MYD88 NLRP3 | 2.35e-05 | 3 | 98 | 2 | 21257968 |
| Pubmed | Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C. | NEDD4L NEDD4 | 2.35e-05 | 3 | 98 | 2 | 19423771 |
| Pubmed | Nedd4-2 but not Nedd4-1 is critical for protein kinase C-regulated ubiquitination, expression, and transport activity of human organic anion transporter 1. | NEDD4L NEDD4 | 2.35e-05 | 3 | 98 | 2 | 26823285 |
| Pubmed | USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation. | NLRP3 USP7 | 2.35e-05 | 3 | 98 | 2 | 30206189 |
| Pubmed | Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy. | NEDD4L NEDD4 | 2.35e-05 | 3 | 98 | 2 | 23686771 |
| Pubmed | RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1. | DDX19B DDX19A | 2.35e-05 | 3 | 98 | 2 | 25585691 |
| Pubmed | Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein. | NEDD4L NEDD4 | 2.35e-05 | 3 | 98 | 2 | 11779188 |
| Pubmed | KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity. | KIF4A KIF4B | 2.35e-05 | 3 | 98 | 2 | 16630823 |
| Pubmed | Rab23 Regulates Radial Migration of Projection Neurons via N-cadherin. | RAB23 MAP2 | 2.35e-05 | 3 | 98 | 2 | 29420702 |
| Pubmed | CircKIF4A enhances osteosarcoma proliferation and metastasis by sponging MiR-515-5p and upregulating SLC7A11. | KIF4A KIF4B | 2.35e-05 | 3 | 98 | 2 | 35579738 |
| Pubmed | 14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase. | NEDD4L NEDD4 | 2.35e-05 | 3 | 98 | 2 | 15677482 |
| Pubmed | Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1-Inhibiting Therapy for Prevention of Atrial and Ventricular Arrhythmias in Mice. | CASQ2 RAPGEF3 | 2.35e-05 | 3 | 98 | 2 | 30518738 |
| Pubmed | Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer. | NEDD4L NEDD4 SYTL4 | 2.78e-05 | 21 | 98 | 3 | 37005481 |
| Pubmed | Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. | SART3 SIN3B PHF23 KIF4A FOXN3 PRPF8 GTF3C3 ZFHX4 EIF5B UTP20 EIF2AK3 | 3.04e-05 | 857 | 98 | 11 | 25609649 |
| Pubmed | Comparative interactome analysis of α-arrestin families in human and Drosophila. | SART3 NEDD4L CWC27 GTF3C3 NEDD4 MFAP1 PTPRS | 3.07e-05 | 313 | 98 | 7 | 38270169 |
| Pubmed | Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. | CCDC125 RANBP6 GTF3C3 NEDD4 PTPRS CERCAM IFT122 EIF3A | 3.15e-05 | 432 | 98 | 8 | 7671812 |
| Pubmed | A central chaperone-like role for 14-3-3 proteins in human cells. | DDX19B DLG5 NEDD4L MAP2 KDM3B NEDD4 PHLDB1 DST CEP89 ARHGEF10 SH3D19 | 3.18e-05 | 861 | 98 | 11 | 36931259 |
| Pubmed | Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. | SART3 DSCAML1 SPTBN4 DST MAST3 | 3.47e-05 | 130 | 98 | 5 | 12421765 |
| Pubmed | FAM188B enhances cell survival via interaction with USP7. | RPS6 PRPF8 USP7 EIF3A | 3.52e-05 | 65 | 98 | 4 | 29795372 |
| Pubmed | E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. | RAB23 SIN3B BCORL1 PRPF8 DSCAML1 ZFYVE28 DST R3HCC1L UTP20 EIF3A | 4.45e-05 | 736 | 98 | 10 | 29676528 |
| Pubmed | The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4. | TBKBP1 DONSON RPS6 PRPF8 DST ARHGEF10 HMGXB3 | 4.46e-05 | 332 | 98 | 7 | 37433992 |
| Pubmed | SGK1/Nedd4-2 signaling pathway regulates the activity of human organic anion transporters 3. | NEDD4L NEDD4 | 4.70e-05 | 4 | 98 | 2 | 28608480 |
| Pubmed | C2-lacking isoform of Nedd4-2 regulates excitatory synaptic strength through GluA1 ubiquitination-independent mechanisms. | NEDD4L NEDD4 | 4.70e-05 | 4 | 98 | 2 | 31357244 |
| Pubmed | Kir5.1 regulates Nedd4-2-mediated ubiquitination of Kir4.1 in distal nephron. | NEDD4L NEDD4 | 4.70e-05 | 4 | 98 | 2 | 29897283 |
| Pubmed | Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal beta-glucan. | MYD88 NLRP3 | 4.70e-05 | 4 | 98 | 2 | 20007575 |
| Pubmed | The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. | AKAP6 RAPGEF3 | 4.70e-05 | 4 | 98 | 2 | 16177794 |
| Pubmed | Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. | MYD88 NLRP3 | 4.70e-05 | 4 | 98 | 2 | 18768827 |
| Pubmed | Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein. | KIF4A KIF4B | 4.70e-05 | 4 | 98 | 2 | 18684836 |
| Pubmed | The NLRP3/ASC inflammasome promotes T-cell-dependent immune complex glomerulonephritis by canonical and noncanonical mechanisms. | MYD88 NLRP3 | 4.70e-05 | 4 | 98 | 2 | 24805106 |
| Pubmed | Ubiquitin-specific protease 7 is a regulator of ubiquitin-conjugating enzyme UbE2E1. | NEDD4 USP7 | 4.70e-05 | 4 | 98 | 2 | 23603909 |
| Pubmed | Kif4 Is Essential for Mouse Oocyte Meiosis. | KIF4A KIF4B | 4.70e-05 | 4 | 98 | 2 | 28125646 |
| Pubmed | PTEN phosphorylation and nuclear export mediate free fatty acid-induced oxidative stress. | NEDD4 USP7 | 4.70e-05 | 4 | 98 | 2 | 24063548 |
| Pubmed | Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels. | NEDD4L NEDD4 | 4.70e-05 | 4 | 98 | 2 | 22024150 |
| Pubmed | Mechanism of impaired NLRP3 inflammasome priming by monophosphoryl lipid A. | MYD88 NLRP3 | 4.70e-05 | 4 | 98 | 2 | 21540455 |
| Pubmed | Inflammasome-independent NLRP3 augments TGF-β signaling in kidney epithelium. | MYD88 NLRP3 | 4.70e-05 | 4 | 98 | 2 | 23264657 |
| Pubmed | The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1. | NEDD4L NEDD4 | 4.70e-05 | 4 | 98 | 2 | 20026598 |
| Pubmed | Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid. | MYD88 NLRP3 | 4.70e-05 | 4 | 98 | 2 | 19783673 |
| Pubmed | The protein dendrite arborization and synapse maturation 1 (Dasm-1) is dispensable for dendrite arborization. | MAP2 EPHA4 | 4.70e-05 | 4 | 98 | 2 | 18268009 |
| Pubmed | The Ubiquitin Ligase Itch and Ubiquitination Regulate BFRF1-Mediated Nuclear Envelope Modification for Epstein-Barr Virus Maturation. | NEDD4L NEDD4 | 4.70e-05 | 4 | 98 | 2 | 27466427 |
| Pubmed | GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2. | NEDD4L NEDD4 | 4.70e-05 | 4 | 98 | 2 | 17544362 |
| Pubmed | Genetic and age related models of neurodegeneration in mice: dystrophic axons. | SPTBN4 DST | 4.70e-05 | 4 | 98 | 2 | 1634998 |
| Pubmed | TLR2/MyD88/NF-κB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection. | MYD88 NLRP3 | 4.70e-05 | 4 | 98 | 2 | 22295065 |
| Pubmed | Role of EphA4 and EphrinB3 in local neuronal circuits that control walking. | SIN3B EPHA4 | 4.70e-05 | 4 | 98 | 2 | 12649481 |
| Pubmed | NEDD4-2 associates with gamma(c) and regulates its degradation rate. | NEDD4L NEDD4 | 4.70e-05 | 4 | 98 | 2 | 19615332 |
| Pubmed | α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Staphylococcus aureus-Infected Wounds. | MYD88 NLRP3 | 4.70e-05 | 4 | 98 | 2 | 28733486 |
| Pubmed | Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel. | NEDD4L NEDD4 | 4.70e-05 | 4 | 98 | 2 | 11696533 |
| Pubmed | Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1. | NEDD4L NEDD4 | 4.70e-05 | 4 | 98 | 2 | 21463633 |
| Interaction | SCN2A interactions | SIN3B NEDD4L NEDD4 USP7 | 1.93e-06 | 19 | 98 | 4 | int:SCN2A |
| ToppCell | E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif | AKAP6 ABRA CASQ2 ZFHX4 UBE2V2 CERCAM ADAMTS14 | 1.27e-07 | 176 | 98 | 7 | 4ed73c73972334f6dc4229920205547823252fa0 |
| ToppCell | 368C-Lymphocytic-NK_cells-NK_cell_E|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells) | RAB23 POLM MIER3 BCORL1 PHLDB1 DST MIA2 | 1.33e-07 | 177 | 98 | 7 | 946803293a7955116c80f403e99e4093e798ca3f |
| ToppCell | Fibroblasts|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues | PHLDB1 DST ZFHX4 PTPRS SH3D19 CERCAM | 5.21e-06 | 199 | 98 | 6 | 40de6d4a31cf22efa2864f79e4ec8e2b7bfc9d4a |
| Disease | Liddle syndrome (implicated_via_orthology) | NEDD4L NEDD4 | 6.26e-05 | 4 | 96 | 2 | DOID:0050477 (implicated_via_orthology) |
| Disease | Abnormal behavior | BCORL1 KDM3B | 1.22e-03 | 16 | 96 | 2 | C0233514 |
| Disease | syndrome (implicated_via_orthology) | DONSON SCAF8 | 1.55e-03 | 18 | 96 | 2 | DOID:225 (implicated_via_orthology) |
| Disease | lung non-small cell carcinoma (is_marker_for) | MYD88 DIABLO BCORL1 KDM3B | 2.29e-03 | 169 | 96 | 4 | DOID:3908 (is_marker_for) |
| Disease | Dwarfism | DONSON KDM3B | 2.99e-03 | 25 | 96 | 2 | C0013336 |
| Disease | left ventricular structural measurement | ABRA CASQ2 EPHA4 | 3.00e-03 | 88 | 96 | 3 | EFO_0008205 |
