Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionepidermal growth factor receptor activity

ERBB4 EGFR

1.60e-0441042GO:0005006
GeneOntologyMolecularFunctionATP-dependent activity

DNHD1 ABCA2 LONP2 NSF SMCHD1 RNF213 DHX57 ATP13A5 SRCAP DDX24 HSPA4

3.56e-0461410411GO:0140657
GeneOntologyMolecularFunctionATP hydrolysis activity

ABCA2 LONP2 NSF SMCHD1 RNF213 DHX57 ATP13A5 SRCAP DDX24

4.97e-044411049GO:0016887
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

CDK20 CDC42BPG SPEG LMTK3 NEK9 PIK3R4 ULK3 MAPK15 EGFR

5.39e-044461049GO:0004674
GeneOntologyMolecularFunctionprotein serine kinase activity

CDK20 CDC42BPG SPEG LMTK3 NEK9 PIK3R4 ULK3 MAPK15

6.24e-043631048GO:0106310
DomainHEAT

CAND2 PIK3R4 DNAAF5 MROH1 NCAPD2 GCN1 HEATR3

7.21e-09481027PF02985
DomainHEAT

CAND2 PIK3R4 DNAAF5 MROH1 NCAPD2 GCN1 HEATR3

2.82e-08581027IPR000357
DomainL_dom-like

NLRP12 ERBB4 PIDD1 PRAMEF12 TPBGL NYX EGFR LGI3 LRCH4 LRRC56 NLRP4

1.78e-0632810211IPR032675
DomainHEAT_type_2

PIK3R4 DNAAF5 MROH1 GCN1

1.89e-06171024IPR021133
DomainHEAT_REPEAT

CAND2 PIK3R4 DNAAF5 MROH1 GCN1 HEATR3

2.26e-06701026PS50077
Domain-

NLRP12 PIDD1 PRAMEF12 TPBGL NYX LGI3 LRCH4 LRRC56 NLRP4

6.60e-0532110293.80.10.10
DomainARM-type_fold

CAND2 APOB PIK3R4 DNAAF5 MROH1 NCAPD2 NOC4L GCN1 HEATR3

1.00e-043391029IPR016024
DomainARM-like

CAND2 PIK3R4 DNAAF5 MROH1 NCAPD2 NOC4L GCN1 HEATR3

1.17e-042701028IPR011989
DomainLeu-rich_rpt

NLRP12 PIDD1 TPBGL NYX LGI3 LRCH4 LRRC56 NLRP4

1.20e-042711028IPR001611
DomainTyr_kinase_EGF/ERB/XmrK_rcpt

ERBB4 EGFR

1.76e-0441022IPR016245
DomainPROTEIN_KINASE_ATP

CDK20 CDC42BPG ERBB4 SPEG LMTK3 NEK9 PIK3R4 ULK3 MAPK15 EGFR

2.06e-0445910210PS00107
Domain-

CAND2 PIK3R4 DNAAF5 MROH1 NCAPD2 GCN1 HEATR3

2.16e-0422210271.25.10.10
DomainPROTEIN_KINASE_DOM

CDK20 CDC42BPG ERBB4 SPEG LMTK3 NEK9 PIK3R4 ULK3 MAPK15 EGFR

3.64e-0449310210PS50011
DomainGF_recep_IV

ERBB4 EGFR

4.37e-0461022PF14843
DomainGF_recep_IV

ERBB4 EGFR

4.37e-0461022IPR032778
DomainRecep_L_domain

ERBB4 EGFR

6.09e-0471022PF01030
DomainFurin-like

ERBB4 EGFR

6.09e-0471022PF00757
DomainRcpt_L-dom

ERBB4 EGFR

6.09e-0471022IPR000494
DomainFurin-like_Cys-rich_dom

ERBB4 EGFR

6.09e-0471022IPR006211
Domain-

ERBB4 EGFR

6.09e-04710223.80.20.20
Domain-

DNHD1 NLRP12 ABCA2 LONP2 NSF RNF213 DHX57 SRCAP TRANK1 CHST2 DDX24 NLRP4

7.57e-04746102123.40.50.300
DomainProt_kinase_dom

CDK20 CDC42BPG ERBB4 SPEG NEK9 PIK3R4 ULK3 MAPK15 EGFR

1.43e-034891029IPR000719
Domain-

NLRP12 PIDD1 MALT1 NLRP4

1.69e-039310241.10.533.10
DomainQuinoprot_gluc/sorb_DH

HHIP LGI3

1.88e-03121022IPR011041
DomainDEATH-like_dom

NLRP12 PIDD1 MALT1 NLRP4

2.12e-03991024IPR011029
DomainP-loop_NTPase

DNHD1 NLRP12 ABCA2 LONP2 NSF RNF213 DHX57 SRCAP TRANK1 CHST2 DDX24 NLRP4

2.25e-0384810212IPR027417
DomainLRR_8

PIDD1 TPBGL NYX LGI3 LRCH4

2.47e-031711025PF13855
DomainKinase-like_dom

CDK20 CDC42BPG ERBB4 SPEG NEK9 PIK3R4 ULK3 MAPK15 EGFR

2.86e-035421029IPR011009
DomainLRR_TYP

PIDD1 TPBGL NYX LGI3 LRCH4

2.87e-031771025SM00369
DomainLeu-rich_rpt_typical-subtyp

PIDD1 TPBGL NYX LGI3 LRCH4

2.87e-031771025IPR003591
DomainSer/Thr_kinase_AS

CDK20 CDC42BPG SPEG NEK9 PIK3R4 ULK3 MAPK15

3.44e-033571027IPR008271
DomainS_TKc

CDK20 CDC42BPG SPEG NEK9 PIK3R4 ULK3 MAPK15

3.54e-033591027SM00220
DomainPROTEIN_KINASE_ST

CDK20 CDC42BPG SPEG NEK9 PIK3R4 ULK3 MAPK15

3.71e-033621027PS00108
DomainFurin_repeat

ERBB4 EGFR

4.27e-03181022IPR006212
DomainFU

ERBB4 EGFR

4.27e-03181022SM00261
DomainProtein_kinase_ATP_BS

CDK20 CDC42BPG ERBB4 SPEG ULK3 MAPK15 EGFR

4.76e-033791027IPR017441
DomainPkinase

CDK20 CDC42BPG SPEG NEK9 PIK3R4 ULK3 MAPK15

4.90e-033811027PF00069
DomainLRR

NLRP12 PIDD1 LGI3 LRCH4 LRRC56

4.92e-032011025PS51450
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ABCA2 ESYT1 SPEG CEP192 SRCAP BIRC6 CCDC88C INTS5 MROH1 RPAP1 PLA2G4B NCAPD2 LRRC56 PDCD11 ZFYVE26 DOCK6 ALKBH6 GCN1 ARHGAP33

1.15e-0911051071935748872
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

AMFR CAND2 CORO2A NSF VPS45 ESYT1 RNF213 DHX57 TUBGCP2 PHGDH LGALS3BP DNAAF5 NCAPD2 PDCD11 NOC4L DDX24 GCN1 HSPA4 SLC39A7 HEATR3

1.48e-0814401072030833792
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DENND2A ABCA2 CAND2 SMCHD1 FASTKD2 INTS5 TRANK1 INTS2 NCAPD2 PDCD11 RIMS2 DOCK6

9.07e-085291071214621295
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

AMFR CAND2 NSF ESYT1 TUBGCP2 RTN2 PHGDH DNAAF5 INTS5 RPAP1 MOGS NCAPD2 GCN1 HSPA4 HEATR3

2.06e-079421071531073040
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

DNHD1 NSF ESYT1 SMCHD1 APOB FASTKD2 NEK9 PHGDH PIK3R4 MAPK15 MOGS NCAPD2 PDCD11 NOC4L CHST2 DDX24 GCN1 HSPA4

3.47e-0714251071830948266
Pubmed

Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.

NSF ESYT1 NELFB PHGDH NCAPD2 DOCK6 DDX24 GCN1 HSPA4 SLC39A7

4.62e-073991071037536630
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

NSF ESYT1 NELFB TUBGCP2 NEK9 PHGDH DNAAF5 NCAPD2 PDCD11 NOC4L GCN1 HSPA4

6.65e-076381071233239621
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

ESYT1 SMCHD1 APOB FASTKD2 BIRC6 MFF PHGDH LGALS3BP DNAAF5 MOGS EGFR PTRH1 PDCD11 NOC4L HSPA4 SLC39A7

2.27e-0612971071633545068
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

AMFR TUBGCP2 BIRC6 PHGDH DNAAF5 RPAP1 MOGS INTS2 NCAPD2 GCN1 HEATR3

6.04e-066571071136180527
Pubmed

Cooverexpression of ERBB1 and ERBB4 receptors predicts poor clinical outcome in pN+ oral squamous cell carcinoma with extranodal spread.

ERBB4 EGFR

9.38e-062107224338375
Pubmed

Regulation of β1 integrin-Klf2-mediated angiogenesis by CCM proteins.

KLF2 CCM2

9.38e-062107225625207
Pubmed

Induction of KLF2 by Exercise Activates eNOS to Improve Vasodilatation in Diabetic Mice.

KLF2 NOS3

9.38e-062107237347764
Pubmed

Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells.

AMFR APOB

9.38e-062107212670940
Pubmed

Trophoblast subtype-specific EGFR/ERBB4 expression correlates with cell cycle progression and hyperplasia in complete hydatidiform moles.

ERBB4 EGFR

9.38e-062107225740878
Pubmed

Genetic variations in EGFR and ERBB4 increase susceptibility to cervical cancer.

ERBB4 EGFR

9.38e-062107223927961
Pubmed

Cancer regulator EGFR-ErbB4 heterodimer is stabilized through glycans at the dimeric interface.

ERBB4 EGFR

9.38e-062107236427180
Pubmed

erbB-1 and erbB-4 receptors act in concert to facilitate female sexual development and mature reproductive function.

ERBB4 EGFR

9.38e-062107215591145
Pubmed

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.

DHX57 LMTK3 SRCAP

1.01e-0514107328263302
Pubmed

Defining the membrane proteome of NK cells.

AMFR ABCA2 LONP2 ESYT1 RNF213 TUBGCP2 BIRC6 PIK3R4 INTS5 MOGS INTS2 NCAPD2 DDX24 GCN1

1.43e-0511681071419946888
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

ESYT1 SMCHD1 DHX57 FASTKD2 SRCAP BIRC6 NEK9 PHGDH PIK3R4 TFB1M NCAPD2 PDCD11 DDX24 GCN1 HSPA4

1.72e-0513531071529467282
Pubmed

Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.

RNF213 PHGDH DNAAF5 EGFR GCN1 HEATR3

2.27e-05183107623956138
Pubmed

Heparin-binding epidermal growth factor and its receptors mediate decidualization and potentiate survival of human endometrial stromal cells.

ERBB4 EGFR

2.81e-053107215562026
Pubmed

Fractionated radiation suppresses Kruppel-like factor 2 pathway to a greater extent than by single exposure to the same total dose.

KLF2 NOS3

2.81e-053107232382091
Pubmed

Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells.

KLF2 NOS3

2.81e-053107216043642
Pubmed

Spontaneous activation and signaling by overexpressed epidermal growth factor receptors in glioblastoma cells.

ERBB4 EGFR

2.81e-053107212532415
Pubmed

ErbB receptor signaling directly controls oligodendrocyte progenitor cell transformation and spontaneous remyelination after spinal cord injury.

ERBB4 EGFR

2.81e-053107230637799
Pubmed

MALT1 is a potential therapeutic target in glioblastoma and plays a crucial role in EGFR-induced NF-κB activation.

MALT1 EGFR

2.81e-053107232452133
Pubmed

Angiotensin II-aldosterone interaction in human coronary microarteries involves GPR30, EGFR, and endothelial NO synthase.

EGFR NOS3

2.81e-053107222260839
Pubmed

ErbB1 and ErbB4 generate opposing signals regulating mesenchymal cell proliferation during valvulogenesis.

ERBB4 EGFR

2.81e-053107228232522
Pubmed

Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs.

CDH23 DCHS1

2.81e-053107211597768
Pubmed

Association of eNOS and HSP70 gene polymorphisms with glaucoma in Pakistani cohorts.

HSPA4 NOS3

2.81e-053107220069064
Pubmed

ErbB receptors protect the perfused heart against injury induced by epinephrine combined with low-flow ischemia.

ERBB4 EGFR

2.81e-053107219370475
Pubmed

Differential Expression Patterns of EGF, EGFR, and ERBB4 in Nasal Polyp Epithelium.

ERBB4 EGFR

2.81e-053107227285994
Pubmed

NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis.

NCOA1 NLRP4

2.81e-053107238730334
Pubmed

Changes in the expression and cytological localization of betacellulin and its receptors (ErbB-1 and ErbB-4) in the trophoblasts in human placenta over the course of pregnancy.

ERBB4 EGFR

2.81e-053107215248827
Pubmed

Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation.

EEF1AKMT4-ECE2 EEF1AKMT4

2.81e-053107228520920
Pubmed

Lifestyle and socioeconomic-status modify the effects of ADRB2 and NOS3 on adiposity in European-American and African-American adolescents.

APOB NOS3

2.81e-053107220930716
Pubmed

Epiregulin promotes hair growth via EGFR-medicated epidermal and ErbB4-mediated dermal stimulation.

ERBB4 EGFR

2.81e-053107232700456
Pubmed

SP1-induced upregulation of the long noncoding RNA TINCR regulates cell proliferation and apoptosis by affecting KLF2 mRNA stability in gastric cancer.

KLF2 TINCR

2.81e-053107225728677
Pubmed

Absence of EGFR, ERBB2 and ERBB4 mutation homologous to the oncogenic ERBB3 Val-104 mutation in colorectal cancers.

ERBB4 EGFR

2.81e-053107224862237
Pubmed

Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma.

ERBB4 EGFR

2.81e-053107215026342
Pubmed

The protective effect of betacellulin against acute pancreatitis is ERBB4 dependent.

ERBB4 EGFR

2.81e-053107231456099
Pubmed

Molecular cloning of a mouse submaxillary gland renin cDNA fragment.

PAPPA2 LRCH4

2.81e-05310726171818
Pubmed

Evaluation of type 1 growth factor receptor family expression in benign and malignant thyroid lesions.

ERBB4 EGFR

2.81e-053107218424286
Pubmed

Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS.

KLF2 NOS3

2.81e-053107220042720
Pubmed

Association of ErbB1-4 expression in invasive breast cancer with clinicopathological characteristics and prognosis.

ERBB4 EGFR

2.81e-053107223100016
Pubmed

Kinase activator-receiver preference in ErbB heterodimers is determined by intracellular regions and is not coupled to extracellular asymmetry.

ERBB4 EGFR

2.81e-053107225468910
Pubmed

Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4.

ERBB4 EGFR

2.81e-05310729419975
Pubmed

Neuregulin 1-erbB signaling is necessary for normal myelination and sensory function.

ERBB4 EGFR

2.81e-053107216554459
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

SMCHD1 DHX57 EGFR NCAPD2 DOCK6 GCN1

3.96e-05202107633005030
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ERBB4 IL16 ZNF219 PRSS56 RNF213 TUBGCP2 SRCAP LGALS3BP MALT1 FOXL2NB DDX24 SLC39A7 ARHGAP33

3.97e-0511161071331753913
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

LONP2 NSF VPS45 ESYT1 DHX57 MFF PHGDH INTS5 TFB1M INTS2 NCAPD2 PTRH1 LRCH4 PDCD11 NOC4L

5.49e-0514971071531527615
Pubmed

The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4: a study in bladder cancer patients.

ERBB4 EGFR

5.60e-054107216685269
Pubmed

Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay.

ERBB4 EGFR

5.60e-054107224557338
Pubmed

Inverse regulation of EGFR/HER1 and HER2-4 in normal and malignant human breast tissue.

ERBB4 EGFR

5.60e-054107223991224
Pubmed

Expression of epidermal growth factors, erbBs, in the nasal mucosa of patients with chronic hypertrophic rhinitis.

ERBB4 EGFR

5.60e-054107222327010
Pubmed

Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.

ERBB4 EGFR

5.60e-054107217177598
Pubmed

The relevance of EGFR, ErbB receptors and neuregulins in human adipocytes and adipose tissue in obesity.

ERBB4 EGFR

5.60e-054107236411648
Pubmed

Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation.

ERBB4 EGFR

5.60e-05410729135143
Pubmed

Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy.

EGFR HSPA4

5.60e-054107212006493
Pubmed

HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer.

ERBB4 EGFR

5.60e-054107221203579
Pubmed

Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase.

NLRP12 HSPA4

5.60e-054107217947705
Pubmed

ErbB2 and ErbB4 Cbl binding sites can functionally replace the ErbB1 Cbl binding site.

ERBB4 EGFR

5.60e-054107219263517
Pubmed

WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function.

ERBB4 EGFR

5.60e-054107216061658
Pubmed

The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases.

ERBB4 EGFR

5.60e-054107215345710
Pubmed

Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells.

DCHS2 DCHS1

5.60e-054107235420656
Pubmed

Analysis of ErbB receptors in pulmonary carcinoid tumors.

ERBB4 EGFR

5.60e-054107219447869
Pubmed

Evaluation of the prognostic and predictive value of HER family mRNA expression in high-risk early breast cancer: a Hellenic Cooperative Oncology Group (HeCOG) study.

ERBB4 EGFR

5.60e-054107218985033
Pubmed

Association of EGF Receptor and NLRs signaling with Cardiac Inflammation and Fibrosis in Mice Exposed to Fine Particulate Matter.

NLRP12 EGFR

5.60e-054107227158778
Pubmed

Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function.

ERBB4 EGFR

5.60e-054107212621152
Pubmed

Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2.

ERBB4 EGFR

5.60e-05410729556621
Pubmed

Activated HER-receptors in predicting outcome of ER-positive breast cancer patients treated with adjuvant endocrine therapy.

ERBB4 EGFR

5.60e-054107222854050
Pubmed

The erbB/HER type 1 tyrosine kinase receptor family.

ERBB4 EGFR

5.60e-05410729771475
Pubmed

Expression of the HER-1-4 family of receptor tyrosine kinases in neuroendocrine tumours.

ERBB4 EGFR

5.60e-054107220204273
Pubmed

Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formation.

ERBB4 EGFR

5.60e-054107215733067
Pubmed

HB-EGF regulates Prss56 expression during mouse decidualization via EGFR/ERK/EGR2 signaling pathway.

PRSS56 EGFR

5.60e-054107228611210
Pubmed

WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus.

ERBB4 EGFR

5.60e-054107212807903
Pubmed

HER Family Protein Expression in a Greek Population with Gastric Cancer. A Retrospective Hellenic Cooperative Oncology Group Study.

ERBB4 EGFR

5.60e-054107227069134
Pubmed

The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility.

ERBB4 EGFR

5.60e-054107225140053
Pubmed

Inhibition of Epidermal Growth Factor Receptor Activation Is Associated With Improved Diabetic Nephropathy and Insulin Resistance in Type 2 Diabetes.

EGFR NOS3

5.60e-054107229959129
Pubmed

Vorinostat combined with brigatinib overcomes acquired resistance in EGFR-C797S-mutated lung cancer.

EGFR HSPA4

5.60e-054107233775711
Pubmed

A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor.

ERBB4 EGFR

5.60e-05410728816440
Pubmed

Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors.

NSF EGFR

5.60e-054107222045810
Pubmed

Evaluation of the prognostic significance of HER family mRNA expression in high-risk early breast cancer: a Hellenic Cooperative Oncology Group (HeCOG) validation study.

ERBB4 EGFR

5.60e-054107226021752
Pubmed

Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase.

CYP4A22 NOS3

5.60e-054107221161333
Pubmed

Cilostazol Induces eNOS and TM Expression via Activation with Sirtuin 1/Krüppel-like Factor 2 Pathway in Endothelial Cells.

KLF2 NOS3

5.60e-054107234638626
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

NELFB CEP192 TUBGCP2 BIRC6 CCDC88C LRCH4 DOCK6 HSPA4

7.40e-05446107824255178
Pubmed

Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2.

ESYT1 DHX57 PHGDH MOGS TFB1M PDCD11 DDX24

7.96e-05333107736779763
Pubmed

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.

PDZD7 LMTK3 NEK9 NCOA1 UAP1L1 SLC39A7

8.72e-05233107637704626
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

NLRP12 PRAMEF12 NLRP4

8.77e-0528107325089626
Pubmed

Genome-wide association study of maternal and inherited loci for conotruncal heart defects.

SMCHD1 SLC22A24

9.32e-055107224800985
Pubmed

Tissue interaction mediated by neuregulin-1 and ErbB receptors regulates epithelial morphogenesis of mouse embryonic submandibular gland.

ERBB4 EGFR

9.32e-055107215254894
Pubmed

Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity.

ERBB4 EGFR

9.32e-055107210572067
Pubmed

Expression of epidermal growth factors and a tight junction protein in the nasal mucosa of patients with chronic hypertrophic rhinitis.

ERBB4 EGFR

9.32e-055107223137868
Pubmed

Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.

KLF2 CCM2

9.32e-055107227027284
Pubmed

Gene expression pattern of the epidermal growth factor receptor family and LRIG1 in renal cell carcinoma.

ERBB4 EGFR

9.32e-055107222554477
Pubmed

Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions.

ERBB4 EGFR

9.32e-055107215682390
Pubmed

Neuregulin-1 induces branching morphogenesis in the developing lung through a P13K signal pathway.

ERBB4 EGFR

9.32e-055107215524405
Pubmed

Segregation of receptor and ligand regulates activation of epithelial growth factor receptor.

ERBB4 EGFR

9.32e-055107212646923
Pubmed

Hepatitis C Virus Activates a Neuregulin-Driven Circuit to Modify Surface Expression of Growth Factor Receptors of the ErbB Family.

ERBB4 EGFR

9.32e-055107226886748
InteractionTOP3B interactions

ABCA2 ESYT1 SPEG DHX57 APOB CEP192 SRCAP BIRC6 PHGDH CCNF CCDC88C INTS5 MROH1 RPAP1 MOGS PLA2G4B NCAPD2 LRRC56 PDCD11 ZFYVE26 DOCK6 ALKBH6 GCN1 ARHGAP33

2.29e-07147010224int:TOP3B
InteractionTMEM9B interactions

ABCA2 VPS45 ESYT1 RNF213 INTS5 INTS2 DDX24

1.53e-061111027int:TMEM9B
InteractionGPR45 interactions

AMFR ABCA2 RNF213 TUBGCP2 DNAAF5 INTS5 MROH1 INTS2 MMP15 GCN1

2.93e-0630010210int:GPR45
InteractionGPR182 interactions

AMFR ABCA2 CAND2 RNF213 TUBGCP2 PIK3R4 DNAAF5 INTS5 MROH1 RPAP1 NCAPD2 GCN1

3.27e-0645510212int:GPR182
InteractionSLC33A1 interactions

NAAA VPS45 ESYT1 PHGDH MOGS EGFR DOCK6 SLC39A7

5.33e-061891028int:SLC33A1
InteractionCHRM4 interactions

CAND2 TUBGCP2 DNAAF5 INTS5 GCN1 HEATR3

8.23e-06941026int:CHRM4
InteractionSTIP1 interactions

CDK20 NSF ESYT1 NELFB TUBGCP2 NEK9 PHGDH PIK3R4 CCNF DNAAF5 MAPK15 EGFR NCAPD2 PDCD11 NOC4L GCN1 HSPA4

1.13e-05100610217int:STIP1
InteractionGPR17 interactions

CAND2 RNF213 TUBGCP2 PIK3R4 DNAAF5 INTS5 INTS2 NCAPD2 HEATR3

1.37e-052831029int:GPR17
InteractionNPY2R interactions

CAND2 TUBGCP2 DNAAF5 INTS5 GCN1

2.10e-05661025int:NPY2R
InteractionGYPA interactions

NELFB FASTKD2 DNAAF5 INTS5 INTS2 NCAPD2 HEATR3

2.94e-051741027int:GYPA
InteractionP2RY8 interactions

ABCA2 TUBGCP2 PIK3R4 DNAAF5 MROH1 INTS2 GCN1

3.52e-051791027int:P2RY8
InteractionPOLR2C interactions

NMRAL1 NELFB BIRC6 CCNF DNAAF5 INTS5 RPAP1 EGFR ASB6

5.50e-053381029int:POLR2C
InteractionPTPRH interactions

AMFR ERBB4 CAND2 EGFR GCN1

6.77e-05841025int:PTPRH
InteractionMAS1 interactions

TUBGCP2 DNAAF5 EGFR NCAPD2 GCN1

7.57e-05861025int:MAS1
InteractionLMBR1L interactions

AMFR CAND2 NSF ESYT1 TUBGCP2 RTN2 PHGDH DNAAF5 INTS5 RPAP1 MOGS NCAPD2 GCN1 HSPA4 HEATR3

8.08e-0594610215int:LMBR1L
InteractionNPTN interactions

CAND2 RNF213 DNAAF5 INTS5 MROH1 NOC4L ZFYVE26 GCN1

8.48e-052781028int:NPTN
InteractionNT5C3A interactions

ABCA2 NMRAL1 CDH23 LGALS3BP CCNF

8.92e-05891025int:NT5C3A
InteractionCBX6 interactions

CDH23 RNF213 DHX57 FASTKD2 CCNF TFB1M DDX24 HEATR3

9.60e-052831028int:CBX6
InteractionMOB3C interactions

NSF ESYT1 NELFB PHGDH NCAPD2 DOCK6 DDX24 GCN1 HSPA4

9.69e-053641029int:MOB3C
InteractionFPR1 interactions

AMFR RNF213 TUBGCP2 DNAAF5 INTS2 GCN1

1.03e-041471026int:FPR1
InteractionPOLR2B interactions

CDK20 NELFB PIDD1 CCNF INTS5 RPAP1 INTS2 EGFR ASB6

1.12e-043711029int:POLR2B
InteractionBIRC3 interactions

DNHD1 NSF ESYT1 SMCHD1 APOB FASTKD2 NEK9 PHGDH MAPK15 MOGS EGFR NCAPD2 PDCD11 NOC4L CHST2 DDX24 GCN1 HSPA4

1.17e-04133410218int:BIRC3
InteractionSCN2B interactions

CAND2 RNF213 INTS2 GCN1 HEATR3

1.22e-04951025int:SCN2B
InteractionCD40 interactions

RNF213 DNAAF5 INTS2 GCN1 HSPA4 SLC39A7

1.28e-041531026int:CD40
InteractionC5AR1 interactions

CAND2 RNF213 APOB TUBGCP2 DNAAF5 HEATR3

1.33e-041541026int:C5AR1
GeneFamilyCadherin related

DCHS2 CDH23 DCHS1

3.05e-051766324
GeneFamilyErb-b2 receptor tyrosine kinases

ERBB4 EGFR

7.84e-0546621096
GeneFamilyIntegrator complex

INTS5 INTS2

1.34e-03156621366
GeneFamilyZinc fingers C2H2-type|Kruppel like factors

KLF2 KLF7

1.93e-0318662624
GeneFamilyNLR family

NLRP12 NLRP4

3.73e-0325662666
GeneFamilyPyrin domain containing|Pyrin and HIN domain family

NLRP12 NLRP4

3.73e-0325662994
ToppCellLPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DCHS2 CAND2 SPEG NCAPD2 DCHS1 CHST2

1.98e-06154107616fdafb5c64d2db321554f87129a962d113f1668
ToppCelldroplet-Liver-LIVER-NPC-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPBGL GALNT18 KLF7 DCHS1 CHST2 NOS3

7.71e-06195107685df110f753f58ab017018c54ee454edb4428e29
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DENND2A ERBB4 TPBGL PHGDH EGFR

2.56e-0514410750322fef818a963be00535d5f141f028d43de5c6a
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-Pleural_Mac|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

NAAA PDZD7 TPBGL DCHS1 ZFYVE26

6.14e-0517310758384d533a1071fc65a06e6d9f5f17d8ab00c3966
ToppCellfacs-Aorta-Heart-24m-Myeloid-macrophage|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAAA EID3 CORO2A PTRH1 NOC4L

6.14e-051731075d0d1c8bcef3d9c28ee9a7c64076624b836cb2580
ToppCellfacs-Lung-Endomucin-24m-Myeloid-Myeloid_Dendritic_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NMRAL1 PIDD1 MOGS NOC4L ZFYVE26

6.31e-0517410757565f6d1c743809807d248ab0e098a2474d9c5b9
ToppCellE18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNF213 LGALS3BP EGFR DCHS1 NOC4L

6.84e-0517710758dfadd9852e0c256363471a7cfe6af120c8c51e0
ToppCellE18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNF213 LGALS3BP EGFR DCHS1 NOC4L

6.84e-051771075767b2af5f224d100b22bed32f86cec1cd17e8711
ToppCellfacs-Skin-Anagen-24m-Epithelial-actively_dividing_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMNTD2 FAM186B CCNF NCAPD2 LRRC56

6.84e-0517710758a0f0fbb06cdacb99a3fdba0da3e0494b891db4f
ToppCellE18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNF213 LGALS3BP EGFR DCHS1 NOC4L

6.84e-0517710755ef2527e9b41e62f1724cdabaad9d8979266bb7d
ToppCellE18.5-Endothelial-Endothelial_lymphatic|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNF213 LGALS3BP EGFR DCHS1 NOC4L

6.84e-051771075ae1d2fdd4f67f50c906b27ea084de058c6908aa2
ToppCellfacs-Skin-Anagen-24m-Epithelial-keratinocyte_stem_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LMNTD2 FAM186B CCNF NCAPD2 LRRC56

6.84e-051771075e9d7682517fb30fd2ad535d59779d718a7024c13
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-proliferating_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

GALNT18 DCHS1 MMP15 DOCK6 NOS3

7.81e-051821075997d37ca2af661c92a56add888762724dfccc890
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_SCP_(0)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ERBB4 CORO2A PRSS56 RIMS2 MMP15

8.01e-051831075f517215ff45dec914af52dfdbc4579c19654c3aa
ToppCellPCW_05-06-Neuronal|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ERBB4 CORO2A PRSS56 RIMS2 MMP15

8.87e-05187107503a2ed85b171c887d4f3b0f4fe2e1cb4a853e658
ToppCellCOPD-Myeloid-ncMonocyte|Myeloid / Disease state, Lineage and Cell class

NAAA SMCHD1 CCDC88C MALT1 HEATR3

9.56e-051901075ed978cd5d9da87b49878a330e362762c487f849f
ToppCellMild/Remission-B_activate-7|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SMCHD1 RNF213 LGALS3BP KLF2 TRANK1

9.80e-051911075382686d62f7b8576c44bb9726a4e10dc26fd348e
ToppCellfacs-Marrow-KLS-18m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL11RA CORO2A PHGDH LGALS3BP MOGS

9.80e-05191107551327ba28b2e3052087fa0fc9b7c0339dc09a1e3
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

GALNT18 KLF2 KLF7 DOCK6 NOS3

1.00e-04192107527ff3621e177e7932dd44dd6baa81551ea75a874
ToppCellControl-Myeloid-ncMonocyte|Myeloid / Disease state, Lineage and Cell class

SMCHD1 CCDC88C MALT1 CHST2 HEATR3

1.03e-0419310753479c01aaae7afd7e02d00e0cb21951c0106a0fd
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PAPPA2 DENND2A ERBB4 RNF213 GALNT18

1.05e-041941075e577d9e88390b36b5a09b97fe1026089892275a3
ToppCellCOVID-19_Severe-Non-classical_Monocyte-|COVID-19_Severe / Disease condition and Cell class

NAAA CDH23 KLF2 CCDC88C CCM2

1.05e-041941075d70b9039fd2fef3e4be086513b94fb7e9bc1f670
ToppCellMild/Remission-B_activate-7|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SMCHD1 RNF213 LGALS3BP KLF2 TRANK1

1.05e-04194107501c97543972159a9468272da06e7e611e2c21fae
ToppCellCOVID-19_Severe-Non-classical_Monocyte|COVID-19_Severe / Disease condition and Cell class

NAAA CDH23 KLF2 CCDC88C CCM2

1.05e-0419410755151546812678ae85cb22224084d27b29e3c4724
ToppCelldroplet-Liver-LIVER-NPC-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPBGL GALNT18 KLF7 DCHS1 CHST2

1.08e-041951075f55ab1018a6cde7d517b53e6ce44c3f7bde485c4
ToppCelldroplet-Liver-LIVER-NPC-1m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPBGL GALNT18 KLF7 DCHS1 CHST2

1.08e-041951075ea1b00805391dca8be0883b635768b296369919a
ToppCellCOVID-19_Mild-Non-classical_Monocyte|COVID-19_Mild / Disease condition and Cell class

NAAA CDH23 KLF2 CCM2 CHST2

1.08e-041951075dd00facd20a661ef23fa7fd9a02ee377b8f2d1b9
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SMCHD1 NEK9 KLF2 CCDC88C DDX24

1.08e-041951075ed5f772c82d4dfd1c8735224446ec9feae3fb8c2
ToppCellCOVID-19_Mild-Non-classical_Monocyte-|COVID-19_Mild / Disease condition and Cell class

NAAA CDH23 KLF2 CCM2 CHST2

1.08e-0419510750295d9897830987eec74f51178e14fb0a83723dc
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Macroglial-Glia_progenitor_cell|GW09 / Sample Type, Dataset, Time_group, and Cell type.

NELFB FASTKD2 MAPK15 NCOA1 CHST2

1.11e-0419610757be50b9156394dea44d7b8b476d4dd516abfafae
ToppCellCOVID_non-vent-Lymphocytic-T_cell-CD8+_Memory_T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

ABCA2 RNF213 KLF2 CCDC88C TRANK1

1.13e-041971075836061acd7f0d5de89b16f52ec679bdf09eac9db
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial-oligodendrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA2 NMRAL1 PHGDH HHIP LGI3

1.16e-041981075a183afe4c2034323f77abfa080f359d67da35e8f
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AMFR ABCA2 PHGDH LGI3 CHST2

1.16e-041981075a7e5de81eb7d3d23812c179a001adbaab1506596
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

GALNT18 KLF2 KLF7 DOCK6 NOS3

1.16e-0419810758689090bce9ab6e8f122426a404037e572c6713b
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA2 NMRAL1 PHGDH HHIP LGI3

1.16e-04198107527f0654fb0857e93f030e1a4b1c307b31576bbcd
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Macroglial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA2 NMRAL1 PHGDH HHIP LGI3

1.16e-041981075fef9a4c96450078527b94d25e681410e4ea01b13
ToppCellVE-CD4-antiviral_CD4|VE / Condition, Cell_class and T cell subcluster

SMCHD1 RNF213 LGALS3BP KLF2 TRANK1

1.19e-041991075056a0538ca5e825ae6195b4c76c208708a014533
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Macroglial-oligodendrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA2 NMRAL1 PHGDH HHIP LGI3

1.19e-04199107567d8c7e5356f5d409d4f98e8338cf6c499fd7aee
ToppCellCOVID-19_Moderate|World / disease group, cell group and cell class

NSF SMCHD1 RNF213 TRANK1 DDX24

1.19e-041991075952fac67588ad5676f5939e3c7f8bac803c27064
ToppCellTracheal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CDH23 RNF187 GALNT18 HHIP NOS3

1.19e-041991075079931e7196719f22a89cfad82f452ec67219ee5
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-dn_T|COVID-19_Mild / Disease, condition lineage and cell class

IL16 ESYT1 GALNT18 TRANK1 NCOA1

1.19e-041991075f307d4887b28cf60a591439e278fd668409cb104
ToppCellmild-CD8+_Tem|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SMCHD1 RNF213 CCDC88C TRANK1 DDX24

1.22e-042001075d8aec4904c9420b8f9d7508658ba1e36c66cdfcc
ToppCell10x5'v1-week_14-16-Endothelial-stroma-tip_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

GALNT18 DCHS1 MMP15 DOCK6 NOS3

1.22e-04200107577ac1aa73c16a4f595ff01c6b4e171e0b8fed1e6
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-oligodendrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA2 NMRAL1 PHGDH HHIP LGI3

1.22e-042001075e5b4821fff40566c4a7dc3f74a14e27eb06b165d
DrugCorticosterone [50-22-6]; Down 200; 11.6uM; HL60; HT_HG-U133A

AMFR CORO2A PIDD1 PHGDH CCNF MOGS NCOA1 PDCD11 CHST2 ARHGAP33

2.29e-08194105101307_DN
Drugprochlorperazine dimaleate salt; Down 200; 10uM; PC3; HT_HG-U133A

IL11RA SPEG PIDD1 CCNF INTS5 MOGS PDCD11 IL17RA

3.71e-0619710581215_DN
DrugChloramphenicol [56-75-7]; Down 200; 12.4uM; MCF7; HT_HG-U133A

AMFR KLF2 CCNF MOGS EGFR NCOA1 ZFYVE26 IL17RA

4.00e-0619910585466_DN
Diseasecerebral cavernous malformation (implicated_via_orthology)

CDC42BPG RNF213 CCM2

6.30e-06111013DOID:0060669 (implicated_via_orthology)
Diseaseinterleukin-16 measurement

NLRP12 IL16

3.47e-0531012EFO_0801717
Diseaseprotein-tyrosine kinase 2-beta measurement

NLRP12 APOB

6.93e-0541012EFO_0801969
DiseasenmrA-like family domain-containing protein 1 measurement

NLRP12 NMRAL1

1.15e-0451012EFO_0801844
Diseasecentral nervous system cancer

PAPPA2 KLF7 EGFR

1.63e-04311013EFO_0000326
Diseaseaortic valve disease (implicated_via_orthology)

EGFR NOS3

1.72e-0461012DOID:62 (implicated_via_orthology)
Diseasegallbladder neoplasm

ERBB4 EGFR

6.25e-04111012C0016978
DiseaseMalignant neoplasm of gallbladder

ERBB4 EGFR

6.25e-04111012C0153452
Diseasepro‐interleukin‐16 measurement

NLRP12 IL16

6.25e-04111012EFO_0010629
Diseasebreast carcinoma

AMFR ERBB4 NSF PIDD1 CEP192 PHGDH CCDC88C EGFR FOXL2NB NCOA1 HSPA4

7.38e-04101910111EFO_0000305
DiseaseDEAFNESS, AUTOSOMAL RECESSIVE (disorder)

CDH23 PDZD7

8.83e-04131012C1846647
DiseaseMuscular Dystrophy, Facioscapulohumeral

SMCHD1 HSPA4

8.83e-04131012C0238288
Diseasecentral nervous system cancer, glioblastoma multiforme

EGFR HEATR3

1.03e-03141012EFO_0000326, EFO_0000519
Diseasemedian neuropathy (biomarker_via_orthology)

ERBB4 EGFR

1.03e-03141012DOID:571 (biomarker_via_orthology)
Diseasetransitional cell carcinoma (is_marker_for)

ERBB4 EGFR MMP15

1.33e-03631013DOID:2671 (is_marker_for)
Diseaseoral squamous cell carcinoma (is_marker_for)

ERBB4 EGFR DOCK6

1.33e-03631013DOID:0050866 (is_marker_for)
Diseasesickle cell anemia (is_implicated_in)

APOB NOS3

1.35e-03161012DOID:10923 (is_implicated_in)
DiseaseLipidemias

APOB NOS3

1.53e-03171012C1706412
DiseaseHyperlipidemia

APOB NOS3

1.53e-03171012C0020473
Diseaselaryngeal squamous cell carcinoma (is_marker_for)

ERBB4 EGFR

1.91e-03191012DOID:2876 (is_marker_for)
Diseasebrain age measurement

EEF1AKMT4-ECE2 EEF1AKMT4

2.12e-03201012EFO_0010602
Diseasewaist-hip ratio

PAPPA2 ERBB4 CAND2 SMCHD1 CEP192 BIRC6 HHIP CCM2 TFB1M DOCK6 HSPA4

3.18e-03122610111EFO_0004343

Protein segments in the cluster

PeptideGeneStartEntry
SPAEQELLPLLLDRA

PTRH1

181

Q86Y79
SLLLEPRSLLVLRGP

ALKBH6

161

Q3KRA9
ELRAELDALRALLPP

FAM246A

141

A0A494C0Y3
ELRAELDALRALLPP

FAM246B

141

A0A494C0N9
LRRFLETELVEPLTP

ERBB4

686

Q15303
ALTLPLARLLTAPEL

ESYT1

556

Q9BSJ8
DRPLEESLLNPELIR

CDK20

326

Q8IZL9
LESRLLVPGDILILP

ATP13A5

276

Q4VNC0
ITSLILLPPDILDNR

BIRC6

856

Q9NR09
VLSLPERVEPDRLLS

CCM2

46

Q9BSQ5
EEPERLPCLQRLLDL

ASB6

146

Q9NWX5
ESLEPVLLPLVDRRF

FAM186B

411

Q8IYM0
PERPALVLLLALEEV

DNHD1

1666

Q96M86
IIDREAFSPPILELL

CDH23

2026

Q9H251
LLTLLSRFEDRLPPE

CDC42BPG

156

Q6DT37
TLPEELGDLPLVRLD

LRCH4

196

O75427
LQTLRPLDRELLGPV

DCHS1

846

Q96JQ0
RLLDVSLQSILRPDP

IL11RA

206

Q14626
LPLSPEDLESLRSLQ

IL17RA

826

Q96F46
LRRLLDSLPREALPD

LONP2

171

Q86WA8
NDLLARVEPPLRSVL

HSPA4

311

P34932
LLLPRSDLAVPSELA

LGALS3BP

306

Q08380
LRPDRDIELTLRLNP

NMRAL1

266

Q9HBL8
RPTADELLDRPLLRK

NEK9

296

Q8TD19
TLSERPLDFLDLERP

MFF

121

Q9GZY8
PLLRRLSELLDQAPE

MALT1

36

Q9UDY8
REARPGLPSLLLLLL

NAAA

6

Q02083
PDTSPEALDLLRRLL

MAPK15

271

Q8TD08
LPAPERERIELAATL

FOXL2NB

141

Q6ZUU3
REEAARPRLLPLLLV

MMP15

21

P51511
QPPDLDRIRTLLELE

KDM5D

1411

Q9BY66
LSPELPPRDLRTLQR

LMTK3

231

Q96Q04
DLIPSRDLATLPREA

CCDC88C

1606

Q9P219
ARIRLDEDRLPILEP

EID3

271

Q8N140
EDLVRPLLAILDRPE

PDZD7

591

Q9H5P4
SLSDPELRLLLPCLV

INTS2

36

Q9H0H0
ARELLPLLLPQEDTA

IL16

636

Q14005
LPRDSPDLLLLLRLL

NELFB

331

Q8WX92
PDLIDEALLRPGRLE

NSF

376

P46459
ITPPRLEALLELALR

TUBGCP2

546

Q9BSJ2
PRTLREILPTLFGLL

GCN1

1916

Q92616
EESFRRLDPLLLPVE

KLF7

71

O75840
DPQLALESLDPRTLR

LMNTD2

51

Q8IXW0
RELRELPPTSLADLI

NLRP4

191

Q96MN2
PLLQPTRDVDLILSL

PLA2G4B

626

P0C869
APEREQLASLLRLTP

NKX2-8

111

O15522
SPDRLLAFLLPRLDT

MROH1

346

Q8NDA8
PLLLRLLDPTSSRLG

MOGS

696

Q13724
PQLLRLLSTLAEEPR

NOS3

871

P29474
SPLEPLDLVLLRRLD

DCHS2

241

Q6V1P9
PLPIDRPDLRRTDSL

RIMS2

471

Q9UQ26
LRPPLALLELSSRVE

PRSS36

676

Q5K4E3
PPRLLELAEQSLLRD

PRAMEF12

6

O95522
RALAIPTLEELPREL

PRAMEF12

21

O95522
RLLLRPEVLAEIPRE

PAPPA2

271

Q9BXP8
LIPLLLRGAEAPLTD

ARHGAP33

836

O14559
LLEPELRPEDRILVL

EEF1AKMT4-ECE2

51

P0DPD8
RLLQERELVEPLTPS

EGFR

681

P00533
IPLARITLPDFRLPE

APOB

2701

P04114
VRRLGPLLLDPSLAV

HEATR3

81

Q7Z4Q2
SLLPSLLERAAPEDV

DOCK6

201

Q96HP0
RPRNLTILSLPEDVL

CCNF

26

P41002
LSSSLPLLRELPLEE

DENND2A

821

Q9ULE3
RDLGALTPDERLTPL

DHX57

1041

Q6P158
RALTLLRFELLPDPT

CYP4A22

471

Q5TCH4
DPILVSLRPGSELLR

CORO2A

391

Q92828
LSDRLPLDRPLPDLR

GALNT18

126

Q6P9A2
LLSLLRPRSAPTELR

ABCA2

2386

Q9BZC7
TSNPEELDPIRLALL

CEP192

1156

Q8TEP8
RPLLGLVLTPTRELA

DDX24

386

Q9GZR7
LLLPRLLRCLSDPAE

DNAAF5

76

Q86Y56
VLSELLRLLRSPLLP

CAND2

736

O75155
RLARLALTAPPEALL

NOC4L

371

Q9BVI4
PADLARLPLLTRLDL

PIDD1

256

Q9HB75
GLEPATLARSLPRLL

PRSS56

541

P0CW18
PERLLAELPALRELA

NYX

151

Q9GZU5
PPSERPLEDLRLRLD

RTN2

131

O75298
EELDLRLRLAQPSSP

RTN2

186

O75298
IVFEPRLPLLSRTLE

SMCHD1

1591

A6NHR9
PPLSRRLLALEEAAA

RNF187

66

Q5TA31
DLLRISIPLDSNLRP

SLC22A24

71

Q8N4F4
APIRRLDPELSLPET

LRRC56

271

Q8IYG6
PTSRLNRLPELELEA

NCOA1

861

Q15788
RDIALSLPQLPRELP

FASTKD2

556

Q9NYY8
LELADIDPTLRPRQL

TFB1M

281

Q8WVM0
LLLRSLPPARAAVLD

INTS5

61

Q6P9B9
REGELPLEELLRSLP

SRCAP

326

Q6ZRS2
PLEELLRSLPPQLLE

SRCAP

331

Q6ZRS2
LLEPELRPEDRILVL

EEF1AKMT4

51

P0DPD7
PEREVLERDLVLPLL

HHIP

126

Q96QV1
RVPLDLSPRLEETLD

AMFR

536

Q9UKV5
VAVLAPLLRDPALDL

CHST2

311

Q9Y4C5
LLPDIISRLSDPELG

NCAPD2

1166

Q15021
APRLSVEILLDRITP

PIK3R4

406

Q99570
DRGLPPVVFLLIRLL

RNF213

4571

Q63HN8
APDIRGRIPLLLTSL

PDCD11

1171

Q14690
ELERLSIPDFLRPLQ

SPEG

1181

Q15772
LVLPEAPRLRLAEPL

SPATC1

221

Q76KD6
LPELLREASPLQSLL

SLC39A7

436

Q92504
LAPEPRAALLAELAL

UAP1L1

26

Q3KQV9
RTEVPPLLLILDRCD

VPS45

206

Q9NRW7
RLSEELLLPLLSQPT

RPAP1

826

Q9BWH6
ADEALLLPLTVRPRD

TINCR

21

A0A2R8Y7D0
LLPLTVRPRDTLSDL

TINCR

26

A0A2R8Y7D0
LLPSDLSERPGLRLA

nan

71

Q6Q795
LSERPGLRLAPLALV

nan

76

Q6Q795
APRALLDRPLLDLDG

TPBGL

266

P0DKB5
EVPLRRDLPLLLFRT

PHGDH

456

O43175
FLRLLSTLQEIPPDL

TRANK1

361

O15050
LQSLREALELPEPRT

ZFYVE26

1091

Q68DK2
RPRSPAARLLLELEE

ZNF219

111

Q9P2Y4
IELPLRPLLSRDCRD

ULK3

231

Q6PHR2
LVSELLRPELDAPLG

KLF2

91

Q9Y5W3
LPRDIFRPLDILNDL

LGI3

151

Q8N145
SAPLQELIRVPERLL

NLRP12

276

P59046