Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein tyrosine kinase binding

DOCK4 ERBB2 SH2B1 PRR7 NEDD9 TJP2 BANK1

1.38e-051491057GO:1990782
GeneOntologyCellularComponentcell leading edge

MPP2 JCAD ERBB2 SORBS2 ATN1 MYO9B PSTPIP1 BCAR1 SH2B1 NEDD9 PAFAH1B1 MTMR9

1.42e-0550011112GO:0031252
GeneOntologyCellularComponentanchoring junction

MPP2 JCAD SORBS2 ATN1 ANK3 PARD3B PANX2 BCAR1 YES1 PRAG1 ZAP70 NEDD9 TJP2 ILDR1 CTNND2 MMP14 PCBP2

1.51e-0597611117GO:0070161
GeneOntologyCellularComponentcell cortex

ARHGAP32 MYO9B PARD3B PSTPIP1 NEDD9 FRY GYS2 PAFAH1B1 MICAL3 BSN

2.89e-0537111110GO:0005938
GeneOntologyCellularComponentperinuclear region of cytoplasm

DOK1 JCAD ERBB2 SORBS2 ATN1 MYO9B PSTPIP1 IRAG1 PRR7 MAP1S PAFAH1B1 SEC16A CACNA1G BANK1 DDX4 MTMR9

3.37e-0593411116GO:0048471
DomainSH3

MPP2 DOCK4 ARHGAP32 SORBS2 PSTPIP1 BCAR1 YES1 NEDD9 SASH3 TJP2

5.02e-0721610810SM00326
DomainSH3

MPP2 DOCK4 ARHGAP32 SORBS2 PSTPIP1 BCAR1 YES1 NEDD9 SASH3 TJP2

5.02e-0721610810PS50002
DomainSH3_domain

MPP2 DOCK4 ARHGAP32 SORBS2 PSTPIP1 BCAR1 YES1 NEDD9 SASH3 TJP2

5.93e-0722010810IPR001452
DomainLRRC37AB_C

LRRC37A3 LRRC37A2 LRRC37A

7.49e-0741083PF14914
DomainLRRC37_N

LRRC37A3 LRRC37A2 LRRC37A

7.49e-0741083IPR032754
DomainLRRC37AB_C

LRRC37A3 LRRC37A2 LRRC37A

7.49e-0741083IPR029423
DomainLRRC37

LRRC37A3 LRRC37A2 LRRC37A

7.49e-0741083PF15779
DomainLRRC37A/B-like

LRRC37A3 LRRC37A2 LRRC37A

7.49e-0741083IPR015753
DomainMed13_N

MED13L MED13

3.31e-0521082PF11597
DomainMediator_Med13_N_met/fun

MED13L MED13

3.31e-0521082IPR021643
DomainMediator_Med13

MED13L MED13

3.31e-0521082IPR009401
DomainMed13_C

MED13L MED13

3.31e-0521082PF06333
DomainSerine_rich

BCAR1 NEDD9

9.90e-0531082IPR014928
DomainSerine_rich

BCAR1 NEDD9

9.90e-0531082PF08824
DomainSH3_2

MPP2 DOCK4 SORBS2 SASH3 TJP2

1.41e-04861085IPR011511
DomainSH3_2

MPP2 DOCK4 SORBS2 SASH3 TJP2

1.41e-04861085PF07653
DomainDUF3513

BCAR1 NEDD9

1.97e-0441082PF12026
DomainCAS_DUF3513

BCAR1 NEDD9

1.97e-0441082IPR021901
DomainSH3_1

ARHGAP32 SORBS2 PSTPIP1 BCAR1 YES1 NEDD9

3.82e-041641086PF00018
DomainTLV_coat

ERVV-2 ERVV-1

6.83e-0471082PF00429
DomainTLV/ENV_coat_polyprotein

ERVV-2 ERVV-1

9.07e-0481082IPR018154
DomainSH3_9

ARHGAP32 SORBS2 PSTPIP1 NEDD9

1.09e-03781084PF14604
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

JCAD ARHGAP32 MAGEL2 ATN1 ANK3 BCAR1 YES1 SH2B1 PRR7 NEDD9 NCOR2 MAP1S BSN

1.32e-094301111335044719
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PALD1 ERBB2 KIF26A MYO9B PER1 MED13L PRAG1 FAM83H NCOR2 MAP1S EIF4G1 SEC16A ZFYVE26 MICAL3 MMP14 HECTD1 PLXNA1 MED13

1.39e-0811051111835748872
Pubmed

Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.

ARHGAP32 SORBS2 MARK1 PARD3B BCAR1 PRAG1 TJP2

4.01e-08102111715778465
Pubmed

Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.

LRRC37A3 LRRC37A2 LRRC37A

1.26e-074111322419166
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DOCK4 JCAD ARHGAP32 ERBB2 SORBS2 PARD3B BCAR1 PRAG1 FAM83H FSIP2 EIF4G1 SEC16A TJP2 HECTD1

6.67e-078611111436931259
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

ARHGAP32 ERBB2 ANK3 MARK1 PARD3B PLEKHA6 YES1 JPH1 SEC16A MICAL3

1.06e-064211111036976175
Pubmed

Evolutionary dynamism of the primate LRRC37 gene family.

LRRC37A3 LRRC37A2 LRRC37A

3.74e-0610111323064749
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ARHGAP32 DMXL2 MARK1 DHX38 RNF8 PER1 PLEKHA6 SH2B1 MICAL3 HECTD1

4.30e-064931111015368895
Pubmed

Regulation of membrane-type 1 matrix metalloproteinase expression by zonula occludens-2 in human lung cancer cells.

TJP2 MMP14

1.01e-052111223605953
Pubmed

The clinical significance of small copy number variants in neurodevelopmental disorders.

MED13L CTNND2

1.01e-052111225106414
Pubmed

NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer.

NEDD9 MMP14

1.01e-052111225241893
Pubmed

Sphingosine-1-phosphate induces the association of membrane-type 1 matrix metalloproteinase with p130Cas in endothelial cells.

BCAR1 MMP14

1.01e-052111218164686
Pubmed

Membrane-type I matrix metalloproteinase-dependent ectodomain shedding of mucin16/ CA-125 on ovarian cancer cells modulates adhesion and invasion of peritoneal mesothelium.

MUC16 MMP14

1.01e-052111225205731
Pubmed

Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.

ERVV-2 ERVV-1

1.01e-052111218826608
Pubmed

Aberrant expression of proteinase-activated receptor 4 promotes colon cancer cell proliferation through a persistent signaling that involves Src and ErbB-2 kinase.

ERBB2 F2RL3

1.01e-052111219058300
Pubmed

Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation.

ERVV-2 ERVV-1

1.01e-052111223555306
Pubmed

YES1 activation induces acquired resistance to neratinib in HER2-amplified breast and lung cancers.

ERBB2 YES1

1.01e-052111231856375
Pubmed

Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development in the mouse.

MED13L MED13

1.01e-052111229325037
Pubmed

p130Cas is an essential transducer element in ErbB2 transformation.

ERBB2 BCAR1

1.01e-052111220505116
Pubmed

Comparative analysis of ZAP-70 expression and Ig VH mutational status in B-cell chronic lymphocytic leukemia.

ZAP70 SLC7A4

1.01e-052111217051526
Pubmed

Identification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells.

ERBB2 BCAR1

1.01e-052111223839042
Pubmed

Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts.

PSTPIP1 BCAR1 TJP2

1.40e-0515111316601135
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

JCAD ARHGAP32 ERBB2 ANK3 PLEKHA6 FAM83H EIF4G1 TJP2 EIF2A PCBP2

1.40e-055651111025468996
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

MPP2 DOCK4 JCAD ARHGAP32 DMXL2 SORBS2 ANK3 MARK1 PER1 PANX2 MAP1S TJP2 CTNND2 BSN

1.65e-0511391111436417873
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

DOCK4 MYO9B DHX38 RNF8 RIOK3 BCAR1 NCOR2 SEC16A BSN PCBP2

1.98e-055881111038580884
Pubmed

Clinical evaluation of the simultaneous determination of CA 15-3, CA 125 and sHER2 in breast cancer.

ERBB2 MUC16

3.02e-053111217852076
Pubmed

LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration.

PAFAH1B1 MMP14

3.02e-053111229934494
Pubmed

Dysregulation of Blimp1 transcriptional repressor unleashes p130Cas/ErbB2 breast cancer invasion.

ERBB2 BCAR1

3.02e-053111228442738
Pubmed

NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis.

NEDD9 MMP14

3.02e-053111224202705
Pubmed

The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42.

BCAR1 NEDD9

3.02e-053111212517963
Pubmed

Immunohistochemical comparison of MUC1, CA125, and Her2Neu in invasive micropapillary carcinoma of the urinary tract and typical invasive urothelial carcinoma with retraction artifact.

ERBB2 MUC16

3.02e-053111219270645
Pubmed

NEDD9 and BCAR1 negatively regulate E-cadherin membrane localization, and promote E-cadherin degradation.

BCAR1 NEDD9

3.02e-053111221765937
Pubmed

Isolation of cDNAs from the Cri-du-chat critical region by direct screening of a chromosome 5-specific cDNA library.

MARCHF6 CTNND2

3.02e-05311129049630
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

JCAD ARHGAP32 LRRC37A3 MUC16 SMOC2 NCOR2 ASXL3 AGK CTNND2 BSN

3.94e-056381111031182584
Pubmed

NRG1 signalling regulates the establishment of Sertoli cell stock in the mouse testis.

ERBB2 NR5A1 DDX4

4.04e-0521111330040984
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

MPP2 ARHGAP32 DMXL2 SORBS2 ANK3 MARK1 PLEKHA6 MAP1S PAFAH1B1 EIF4G1 SEC16A TJP2 MICAL3 CTNND2 BSN

5.08e-0514311111537142655
Pubmed

Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity.

MYT1 ETV6 SEC16A

5.35e-0523111322792062
Pubmed

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.

CCNL2 ETV6 MED13L NCOR2 RALBP1 TJP2 PCBP2 HECTD1 MED13

5.76e-05536111915840001
Pubmed

Exchangeable gene trap using the Cre/mutated lox system.

CCNL2 ETV6 MED13L NCOR2 RALBP1 TJP2 PCBP2 HECTD1 MED13

5.93e-05538111910512203
Pubmed

Clinical value of p53, c-erbB-2, CEA and CA125 regarding relapse, metastasis and death in resectable non-small cell lung cancer.

ERBB2 MUC16

6.03e-054111214566828
Pubmed

A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins.

PCBP4 PCBP2

6.03e-054111214612387
Pubmed

Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae.

BCAR1 NEDD9

6.03e-05411128668148
Pubmed

p130Cas promotes invasiveness of three-dimensional ErbB2-transformed mammary acinar structures by enhanced activation of mTOR/p70S6K and Rac1.

ERBB2 BCAR1

6.03e-054111220961652
Pubmed

Nephrocystin-1 interacts directly with Ack1 and is expressed in human collecting duct.

ARHGAP32 BCAR1

6.03e-054111218477472
Pubmed

Alpha 4 beta 1 integrin-mediated tyrosine phosphorylation in human T cells: characterization of Crk- and Fyn-associated substrates (pp105, pp115, and human enhancer of filamentation-1) and integrin-dependent activation of p59fyn1.

BCAR1 NEDD9

6.03e-05411129366405
Pubmed

Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as a model.

BCAR1 NEDD9

6.03e-05411129748319
Pubmed

FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment.

MED13L MED13

6.03e-054111229809150
Pubmed

Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells.

BCAR1 NEDD9

6.03e-05411129498705
Pubmed

Ligation of the T cell antigen receptor induces tyrosine phosphorylation of p105CasL, a member of the p130Cas-related docking protein family, and its subsequent binding to the Src homology 2 domain of c-Crk.

BCAR1 NEDD9

6.03e-05411129295052
Pubmed

p130Cas scaffold protein regulates ErbB2 stability by altering breast cancer cell sensitivity to autophagy.

ERBB2 BCAR1

6.03e-054111226716506
Pubmed

TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion.

ERBB2 MMP14

6.03e-054111226899482
Pubmed

Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates.

BCAR1 NEDD9

6.03e-05411129360983
Pubmed

Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate.

ATN1 CTNND2

6.03e-054111210332026
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

MPP2 ARHGAP32 DMXL2 SORBS2 ANK3 NHSL2 NCOR2 FRY EIF4G1 SEC16A CTNND2 BSN

6.07e-059631111228671696
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

JCAD DMXL2 SORBS2 ANK3 MED13L SH2B1 JPH1 FRY MAP1S RALBP1 EIF4G1 CTNND2 HECTD1 MED13

6.13e-0512851111435914814
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

ARHGAP32 SORBS2 SH2B1 HECTD1 MED13

6.30e-05130111512421765
Pubmed

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

DOK1 DMXL2 ZAP70 NEDD9 TJP2

7.02e-05133111515144186
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

ARHGAP32 ATN1 MYO9B MUC16 PCDHA1 PLEKHA6 PSTPIP1 ASXL3 MICAL3

7.21e-05552111910737800
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

DOCK4 JCAD ARHGAP32 PARD3B YES1 FAM83H TJP2 MICAL3 EIF2A PCBP2 MTMR9

9.25e-058531111128718761
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

PALD1 ARHGAP32 ERBB2 ANK3 JPH1 EIF4G1 SEC16A AGK MICAL3 EIF2A

9.33e-057081111039231216
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

CCNL2 DONSON MYO9B BCAR1 UST EIF4G1 SEC16A

9.85e-05332111737433992
Pubmed

Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.

PLEKHA6 BCAR1 YES1 PRAG1

1.00e-0475111415951569
Pubmed

Each member of the poly-r(C)-binding protein 1 (PCBP) family exhibits iron chaperone activity toward ferritin.

PCBP4 PCBP2

1.00e-045111223640898
Pubmed

Cyanidin-3-glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2.

ERBB2 BCAR1

1.00e-045111221034468
Pubmed

Coregulatory protein-orphan nuclear receptor interactions in the human adrenal cortex.

NCOR2 NR5A1

1.00e-045111216002533
Pubmed

Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain.

BCAR1 NEDD9

1.00e-045111210502414
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

MARK1 PLEKHA6 JPH1 TJP2 CTNND2 BSN

1.02e-04231111616452087
Pubmed

Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors.

ERBB2 YES1 ZAP70 SH2B1

1.11e-0477111422973453
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

ERBB2 DMXL2 MARK1 RIOK3 YES1 PAFAH1B1 TPSG1 MMP14 PLXNA1 MTMR9

1.20e-047301111034857952
Pubmed

Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.

DOK1 ZAP70 NEDD9

1.21e-0430111312522270
Pubmed

Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.

DOK1 YES1 ZAP70 PCBP2

1.29e-0480111416094384
Pubmed

SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome.

DOK1 BCAR1 SH2B1

1.47e-0432111322974441
Pubmed

The mouse kinome: discovery and comparative genomics of all mouse protein kinases.

PRAG1 PXK

1.50e-046111215289607
Pubmed

Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways.

BCAR1 NEDD9

1.50e-046111210692442
Pubmed

Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets.

ERVV-2 ERVV-1

1.50e-046111223085571
Pubmed

Loss of PGC-specific expression of the orphan nuclear receptor ERR-beta results in reduction of germ cell number in mouse embryos.

NR5A1 DDX4

1.50e-046111215003627
Pubmed

Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas.

DOK1 BCAR1

1.50e-046111211278335
Pubmed

Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins.

PCBP4 PCBP2

1.50e-046111210936052
Pubmed

Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.

F2RL3 DDX4

1.50e-046111220561531
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

MPP2 ARHGAP32 DMXL2 SORBS2 ANK3 CTNND2

1.60e-04251111627507650
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

CCNL2 F2RL3 MARK1 BCAR1 YES1 PRAG1 FAM83H NCOR2 MAP1S RALBP1 EIF4G1

1.63e-049101111136736316
Pubmed

A quantitative protein interaction network for the ErbB receptors using protein microarrays.

DOK1 ERBB2 ZAP70 SH2B1

2.03e-0490111416273093
Pubmed

Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors.

ATN1 NCOR2

2.10e-047111216481466
Pubmed

Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality.

ERBB2 PAFAH1B1

2.10e-047111216107726
Pubmed

The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development.

MED13L MED13

2.10e-047111212093747
Pubmed

Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells.

BCAR1 NEDD9

2.10e-04711129020138
Pubmed

CMS: an adapter molecule involved in cytoskeletal rearrangements.

BCAR1 YES1

2.10e-047111210339567
Pubmed

Steroidogenic Factor 1 (Nr5a1) is Required for Sertoli Cell Survival Post Sex Determination.

NR5A1 DDX4

2.10e-047111230872705
Pubmed

LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

CMTM1 PARP6 FSIP2 NCOR2 ALDH16A1

2.10e-04168111530631154
Pubmed

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.

PALD1 SORBS2 YES1 UST CTNND2 PLXNA1

2.15e-04265111619240061
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

DOK1 MARK1 JPH1 CMTM1 ASXL3 PARPBP PCBP2 HECTD1

2.48e-04513111825798074
Pubmed

Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.

SORBS2 ANK3 PXK

2.66e-0439111322802532
Pubmed

Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.

BCAR1 NEDD9

2.79e-048111220442405
Pubmed

Cas Adaptor Proteins Coordinate Sensory Axon Fasciculation.

BCAR1 NEDD9

2.79e-048111229662228
Pubmed

The matricellular protein SPARC is internalized in Sertoli, Leydig, and germ cells during testis differentiation.

NR5A1 DDX4

2.79e-048111216425238
Pubmed

Syncytins expressed in human placental trophoblast.

ERVV-2 ERVV-1

2.79e-048111233504453
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

ARHGAP32 ERBB2 YES1 NCOR2 SEC16A

2.89e-04180111535198878
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

ARHGAP32 DMXL2 SORBS2 ANK3 PRAG1 CTNND2

2.94e-04281111628706196
Pubmed

Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin.

ERBB2 MED13

3.58e-049111220011118
Pubmed

Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells.

ERBB2 YES1

3.58e-049111223866081
InteractionCRKL interactions

DOK1 ARHGAP32 ERBB2 MAGEL2 ETV6 BCAR1 YES1 PRAG1 ZAP70 NEDD9

4.73e-0722711010int:CRKL
InteractionNCK2 interactions

DOK1 ARHGAP32 ERBB2 SORBS2 ATN1 NHSL2 BCAR1 FAM83H TJP2 NR5A1

1.74e-0626211010int:NCK2
InteractionABL1 interactions

DOK1 ERBB2 SORBS2 PSTPIP1 BCAR1 ZAP70 NEDD9 CTNND2 EIF2A

1.25e-052591109int:ABL1
InteractionCDH1 interactions

JCAD ARHGAP32 ERBB2 ANK3 PLEKHA6 BCAR1 YES1 FAM83H NEDD9 EIF4G1 TJP2 CTNND2 EIF2A PCBP2 HECTD1

1.84e-0576811015int:CDH1
InteractionSLC7A4 interactions

ERBB2 SLC7A4

2.95e-0521102int:SLC7A4
InteractionLCK interactions

DOK1 ARHGAP32 ERBB2 ANK3 PLEKHA6 BCAR1 YES1 ZAP70 JPH1 NEDD9 CTNND2

4.61e-0546311011int:LCK
InteractionPTK2B interactions

DOK1 ERBB2 SORBS2 BCAR1 ZAP70 NEDD9

4.85e-051191106int:PTK2B
CytobandEnsembl 112 genes in cytogenetic band chr6q25

GINM1 MYCT1 ZDHHC14 PNLDC1 UST

5.17e-051641115chr6q25
Cytoband8q21

MSC JPH1

3.76e-041211128q21
CytobandEnsembl 112 genes in cytogenetic band chr17q21

MPP2 LRRC37A2 ADAM11 LRRC37A UBTF CACNA1G

1.06e-034731116chr17q21
Cytoband17q21.31

LRRC37A2 LRRC37A UBTF

1.06e-0382111317q21.31
Cytoband5p15.2

MARCHF6 CTNND2

1.95e-032711125p15.2
GeneFamilyCas scaffolding proteins

BCAR1 NEDD9

8.08e-054672469
CoexpressionHALLMARK_MITOTIC_SPINDLE

DOCK4 SORBS2 MYO9B BCAR1 NEDD9 MAP1S RALBP1 PAFAH1B1

2.03e-061991108M5893
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

DOCK4 ANK3 MARK1 MYT1 PLEKHA6 MED13L PXK JPH1 FSIP2 FRY ASXL3 DACT3 MICAL3 CACNA1G CTNND2 BSN PLXNA1

3.59e-06110611017M39071
CoexpressionGSE17721_CTRL_VS_LPS_4H_BMDC_UP

PALD1 MYO9B NCOR2 RALBP1 SEC16A NR5A1 BSN

2.22e-052001107M3689
CoexpressionHEVNER_CORTICAL_PLATE_POSTMITOTIC_NEURONS

ANK3 FRY SLC7A4 ASXL3 MICAL3 BSN

2.40e-051361106MM407
CoexpressionFAELT_B_CLL_WITH_VH3_21_UP

MYO9B SASH3 UBTF EIF4G1

3.83e-05451104M15164
ToppCellpdx-Tumor_cells-T0|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

SORBS2 ZDHHC14 PARD3B MED13L SMOC2 SLC13A5 CTNND2

4.20e-0718511171d874608aa2062024323512f68889219471b2f00
ToppCellControl-Endothelial-Endothelial-Alv_Gen_Intermediate|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK4 JCAD MYCT1 ZDHHC14 YES1 LTC4S CTNND2

4.85e-0718911175d7ae1ead7f4fbaeec26f651833c9c2106e1e4d1
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK4 ARHGAP32 ANK3 LRRC37A3 PARD3B MED13L UST

6.63e-0719811171996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellNS-control|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ARHGAP32 ERBB2 SORBS2 ANK3 MUC16 TJP2 HECTD1

7.09e-072001117ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCellCOVID-19_Moderate-B_cell|COVID-19_Moderate / disease group, cell group and cell class

MARK1 MYT1 ADAM11 PRR7 MICAL3 BANK1

1.53e-06142111688bb8d9bca66131df4ee7021b88248e146aa7aa6
ToppCell3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JCAD NHSL2 F2RL3 MYCT1 PCDHA1 TJP2

3.06e-06160111633050dc646762dc7e9dcc4a12c618e1ba1ce5a4d
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ZNF597 SORBS2 NHSL2 MYCT1 YES1 ASXL3

4.49e-0617111161ae4b6a25bc9c1065cf5d95998ebcc70aee21ab5
ToppCellwk_20-22-Epithelial-Proximal_epithelial-Proximal_secretory_3|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

MPP2 ARHGAP32 MUC16 SLC7A4 ILDR1 PLXNA1

4.97e-0617411169e5fae9ecc7c0111fc8a252e72b89dc89c0d3a7c
ToppCellCOVID-19-Heart-CM_3|Heart / Disease (COVID-19 only), tissue and cell type

SORBS2 ANK3 JPH1 FRY MICAL3 CTNND2

6.42e-061821116287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

MARK1 PRAG1 JPH1 TJP2 MMP14 RAI2

7.05e-061851116427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORBS2 ANK3 MARK1 GPRC5C IRAG1 CACNA1G

7.05e-06185111630df02fbe2828e3c4f3e5c4cda855e74fb31be39
ToppCelldroplet-Liver-Hepatocytes-21m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB2 KIF26A MYCT1 BCAR1 PRAG1 LTC4S

7.05e-061851116efcfbf5a48b3ea9a425183e5c2eec6a9585415a0
ToppCelldroplet-Liver-Hepatocytes-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERBB2 KIF26A MYCT1 BCAR1 PRAG1 LTC4S

7.05e-061851116642088ace9230d38b0579853c54ff4dd8b5d5df4
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORBS2 ANK3 MARK1 GPRC5C IRAG1 CACNA1G

7.50e-0618711168ff9f771d10c372d771c92dfa9006aa81aec4681
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JCAD KIF26A NHSL2 F2RL3 MYCT1 NEDD9

7.73e-0618811160026c9479b30fb39daa91cfa220a88f9c9e65fe7
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

RHCG JCAD PSTPIP1 IRAG1 PRAG1 UST

7.97e-0618911160abc7a4900cc9033bc1be69b770ccc54a6bf41b4
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

PALD1 F2RL3 MYCT1 ZDHHC14 BCAR1 MICAL3

8.21e-0619011166e6ce6dd549d1c38cfef5b3f8be06ab01ce344b7
ToppCellControl-Endothelial-Endothelial|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK4 JCAD ZDHHC14 YES1 NEDD9 CTNND2

8.98e-061931116aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCellControl-Endothelial|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK4 JCAD ZDHHC14 YES1 NEDD9 CTNND2

8.98e-061931116c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCellControl-Endothelial-Endothelial-Gen_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK4 MYCT1 ZDHHC14 YES1 NEDD9 CTNND2

8.98e-061931116e1d546165dcc2392f540162206852c4717d7306f
ToppCell(6)_Endothelial-C_(Capillary_Aerocyte_)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

DOCK4 PALD1 JCAD F2RL3 MYCT1 FRY

8.98e-061931116f7f2dc6aff02d096a282835094d26d12b3b73e61
ToppCellCOVID-19-Heart-EC_1|Heart / Disease (COVID-19 only), tissue and cell type

DOCK4 JCAD MYCT1 YES1 PRAG1 NEDD9

9.52e-06195111650a193475db1bb1e05b8590225a553688c372c14
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK4 ANK3 LRRC37A3 PARD3B MED13L UST

9.80e-061961116ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellCOVID-19-lung-Capillary_Aerocytes|COVID-19 / Disease (COVID-19 only), tissue and cell type

DOCK4 PALD1 JCAD F2RL3 ZDHHC14 NEDD9

9.80e-06196111649cc0a2b9739abad61dff7292ea0b14d28ff35c4
ToppCellCOVID-19-lung-Capillary_Aerocytes|lung / Disease (COVID-19 only), tissue and cell type

PALD1 JCAD F2RL3 ZDHHC14 NEDD9 FRY

9.80e-0619611164ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MARK1 SMOC2 IRAG1 FRY DACT3 MICAL3

1.01e-051971116bf0520a94ebb1d2f94de9f526d17e0b0e8fe7052
ToppCellBronchial_Biopsy-Mesenchymal-Smooth_muscle|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X

SORBS2 KIF26A GPRC5C SMOC2 ZAP70 FRY

1.01e-05197111698f0184a09563a544f0c2d4df22c9db2fbc95019
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

DOCK4 PALD1 JCAD NHSL2 F2RL3 MYCT1

1.04e-0519811168689090bce9ab6e8f122426a404037e572c6713b
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

ARHGAP32 ANK3 LRRC37A3 ETV6 PARD3B MED13L

1.07e-05199111694b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JCAD KIF26A NHSL2 F2RL3 MYCT1 NEDD9

1.07e-051991116f0bf75bfae7b288ecb6801be458b03ebd0108ea7
ToppCellcontrol|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ARHGAP32 ERBB2 SORBS2 ANK3 TJP2 HECTD1

1.10e-05200111697f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCellmedial-Endothelial|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PALD1 JCAD F2RL3 MYCT1 NEDD9 FRY

1.10e-052001116e889b593c2ae53c42944213ce8672cd886917105
ToppCelldistal-1-Endothelial|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

JCAD F2RL3 MYCT1 NEDD9 FRY LTC4S

1.10e-0520011168f25b27c10e89cf9d0091bd53c24ce63ed7d6222
ToppCellmedial-2-Endothelial|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PALD1 JCAD F2RL3 MYCT1 NEDD9 FRY

1.10e-05200111670440db2d8be1e29aeb34ea5e8ac72641b5c056f
ToppCelldistal-2-Endothelial-Capillary_Intermediate_1|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PALD1 JCAD F2RL3 ZDHHC14 NEDD9 FRY

1.10e-0520011167a99f28670ffb8ece7873d8a9bcd2a3936d0255d
ToppCelldistal-Endothelial-Capillary_Intermediate_1-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PALD1 JCAD F2RL3 ZDHHC14 NEDD9 FRY

1.10e-05200111643bc48413b100a06f8edd9acd812296788fcbf5b
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JCAD KIF26A NHSL2 F2RL3 MYCT1 NEDD9

1.10e-05200111690061284a80d29a4ca6078f578e13d32b8cc80e1
ToppCelldistal-Endothelial-Capillary_Intermediate_1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PALD1 JCAD F2RL3 ZDHHC14 NEDD9 FRY

1.10e-0520011164d6714d48738cdee7d535923f6dd2431e5304741
ToppCellCOVID-19_Moderate-B_cell|World / disease group, cell group and cell class

MARK1 MYT1 ADAM11 MICAL3 BANK1

2.58e-051391115b93e1da87d44e55d75e8cc1b87c2970645679c01
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Neuroendocrine_Carcinoma-2|TCGA-Pancreas / Sample_Type by Project: Shred V9

MPP2 LRRC37A3 MYT1 PCDHA1 BSN

3.27e-051461115bc2adef529d0bbfcccef7435401a47a6ffcc1832
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Neuroendocrine_Carcinoma|TCGA-Pancreas / Sample_Type by Project: Shred V9

MPP2 LRRC37A3 MYT1 PCDHA1 BSN

3.27e-05146111572c1e7e0c2b6ff6c4084af61fa19c2b8eab16eda
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

MPP2 MARK1 SMOC2 IRAG1 DACT3

5.05e-051601115fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D122|Adult / Lineage, Cell type, age group and donor

MPP2 MARK1 PNLDC1 IRAG1 DACT3

5.20e-05161111564891f6f2ee1693c8481e951b9346e2f92d602e3
ToppCell367C-Myeloid-Monocyte-CD16+_Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ZNF597 LRRC37A2 PRR7 LRRC37A MED13

5.68e-0516411151aff83fc73b4e41e6f0d4b04dbca153bcc7a3518
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 RIOK3 IRAG1 UST CACNA1G

5.68e-051641115f9a2cc12179d5621c9174ec01d7418a71edd28d1
ToppCelldroplet-Lung-LUNG-1m-Myeloid-plasmacytoid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP32 ZDHHC14 ADAM11 IRAG1 CTNND2

6.02e-0516611156e6075d0c913e2516083f6dcab21d5878bcef7a4
ToppCelldroplet-Lung-1m-Hematologic-myeloid-plasmacytoid_dendritic_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARHGAP32 ZDHHC14 ADAM11 IRAG1 CTNND2

6.02e-0516611151ca888ae8168707493f19ee52a89d7c70e6cb51d
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Plasmacytoid_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP32 ZDHHC14 ADAM11 IRAG1 CTNND2

6.02e-0516611154fbe44e0aea197893614cd55f83119aa0f73ee53
ToppCelldroplet-Lung-1m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ARHGAP32 ZDHHC14 ADAM11 IRAG1 CTNND2

6.02e-0516611154cba4ca1aa2321b9ef7cd230932b890d2434a252
ToppCellBronchial_Biopsy-Immune-T_and_NK|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

JCAD MSC SMOC2 FSIP2 FRY

6.37e-051681115435b2f238fbb3f50427e8cdecf2220615015153c
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 GPRC5C IRAG1 UST DACT3

7.12e-0517211157fb31ccbcd0204c3612986a6bc20d57ed6825e9c
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 GPRC5C IRAG1 UST DACT3

7.12e-0517211152a4614b3d25e8c6b095e6992d8ca35371dcdb5e1
ToppCelldroplet-Lung-nan-21m-Myeloid-Proliferating_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZDHHC14 IRAG1 CTNND2 PARPBP XKR5

7.31e-0517311152eb6e9fc3a3654f6f86fbd112e80a18814afd103
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

MARK1 SMOC2 IRAG1 DACT3 MICAL3

7.31e-051731115a5331721bd9f9a66530dd4ffe28cb3a5a8cad8fc
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Myeloid-microglial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLCA4 SASH3 ILDR1 LTC4S BANK1

7.52e-0517411158d6df5938cef542f23259ce471eea1a1afbed03c
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Myeloid|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLCA4 SASH3 ILDR1 LTC4S BANK1

7.52e-0517411152af54c3427aacfa232e2aca6003b4a8ecb8bba66
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Myeloid-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLCA4 SASH3 ILDR1 LTC4S BANK1

7.52e-051741115eca643b8f5b92aeed5a77c94b4301fd8100f9401
ToppCellCOVID-19-Heart-VSMC|COVID-19 / Disease (COVID-19 only), tissue and cell type

MARK1 SMOC2 IRAG1 FRY DACT3

7.72e-0517511151125f0d3a5b2388fa77a820dea0288e824d84a82
ToppCellpdx-Tumor_cells-T2|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

SORBS2 ZDHHC14 PARD3B SLC13A5 CTNND2

7.93e-0517611151e21f80cf0e695ffdd63e4a72cf1e3fa41b60341
ToppCell390C-Fibroblasts-Fibroblast-B_(Myofibroblast)|390C / Donor, Lineage, Cell class and subclass (all cells)

MARK1 IRAG1 CACNA1G PCBP4 RAI2

7.93e-051761115852d3da0907fe87c0ef23d75a63ce07619cf0c54
ToppCell390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-|390C / Donor, Lineage, Cell class and subclass (all cells)

MARK1 IRAG1 CACNA1G PCBP4 RAI2

7.93e-051761115d2df1e435996c51213e88270af9f928e9e09a6f5
ToppCelltumor_Lung-Endothelial_cells-EPCs|tumor_Lung / Location, Cell class and cell subclass

JCAD LRRC37A3 KIF26A F2RL3 MYCT1

8.15e-051771115f8b152c09d56a97e8c0482fb1a3964c05f9dc8c5
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6|TCGA-Ovary / Sample_Type by Project: Shred V9

MSC IRAG1 DACT3 KLF17 MMP14

8.37e-051781115142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCelldroplet-Spleen-SPLEEN-1m-Myeloid-macrophage_dendritic_cell_progenitor|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 MYCT1 ADAM11 IRAG1 CTNND2

8.37e-051781115742ee0cb8cb585a5e34bd5b20aebe9bb99756e0c
ToppCelldroplet-Liver-LIVER_NPC-30m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK4 ARHGAP32 KIF26A MYCT1 BCAR1

8.59e-051791115025d414ec88d5680d99c8173e70ee3bb0b694f74
ToppCellfacs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORBS2 MARK1 GPRC5C IRAG1 FRY

8.59e-0517911158da6863edc756540bb097cc7221c1408640d9bb4
ToppCellfacs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORBS2 MARK1 GPRC5C IRAG1 FRY

8.59e-051791115f39c13c99a07d009cc677e363ffe089089c64916
ToppCell5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JCAD NHSL2 F2RL3 MYCT1 NEDD9

9.29e-05182111563b41b538b26bc899558807fd035e543611f8c52
ToppCell5'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SORBS2 SMOC2 IRAG1 DACT3 CTNND2

9.53e-05183111561a73de857f4ae02dcba3af348f436f602b28ff2
ToppCellCOPD-Epithelial-Mesothelial|World / Disease state, Lineage and Cell class

MUC16 PARD3B SMOC2 SLC7A4 TJP2

1.00e-04185111523579988036fc1925992c31919750f9b3fe9f790
ToppCelldroplet-Marrow-nan-18m-Hematologic-hematopoietic_precursor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

F2RL3 MYCT1 IRAG1 ZAP70 BSN

1.00e-041851115de353368f4f6a7a0a66e391d586879876fbe2734
ToppCell343B-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

DOCK4 PALD1 ZDHHC14 LTC4S MMP14

1.03e-0418611159673367cb53bafb873a01ef6bda11d9f392ce648
ToppCelldroplet-Heart-nan-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MPP2 MARK1 GPRC5C IRAG1 DACT3

1.05e-04187111559313a47a6012b2413d7d3673bb05fb7e49fd88f
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

RHCG JCAD IRAG1 PRAG1 UST

1.05e-041871115387cb27c8a20031cd87381a9e1172f1f62e1488b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 PALD1 JCAD F2RL3 MYCT1

1.05e-04187111535c382c0aabd46906113e5db30ea24bb8e658899
ToppCelldroplet-Heart-nan-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MPP2 MARK1 GPRC5C IRAG1 DACT3

1.05e-0418711152591fe1552cd10925ad1d8d1f062a057ce6bdad9
ToppCelldroplet-Large_Intestine-COLON:P+D-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLCA4 SORBS2 SMOC2 TPSG1 MMP14

1.05e-041871115a63fa3255ad58f3a73c596df99ce9649fdbaeb39
ToppCellFetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PALD1 JCAD F2RL3 ZDHHC14 NEDD9

1.05e-04187111597b2463fb37e7196dd2f92553acf8e7bc3ec40dd
ToppCelldroplet-Large_Intestine-COLON:P+D|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLCA4 SORBS2 SMOC2 TPSG1 MMP14

1.05e-041871115b1bb5c48258a9d058614d23001899dbe44857a1f
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SORBS2 ANK3 DHX38 MUC16 ILDR1

1.05e-041871115f5a202d5f8eb57b57d80815ce98774e04c387383
ToppCellfacs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RHCG SORBS2 GPRC5C IRAG1 SLC7A4

1.08e-041881115340f0e3e65c7a00d82d26621ff37107458bebc41
ToppCelldroplet-Large_Intestine-COLON:P+D-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLCA4 SORBS2 SMOC2 TPSG1 MMP14

1.08e-041881115bfd3b4f57785596b2bd2c657e0d2d8b0f40ba36d
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

ZDHHC14 ETV6 IRAG1 NEDD9 FRY

1.08e-04188111534e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCellCOPD-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

PALD1 F2RL3 ZDHHC14 MED13L FRY

1.08e-0418811151aa0e35b1c28ac847886fece16c3ef7fc6fcdd51
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel|Children_(3_yrs) / Lineage, Cell type, age group and donor

PALD1 MYCT1 ZDHHC14 BCAR1 MICAL3

1.08e-041881115c2805232618a7b6f844d34e37ad458a9923dbfe1
ToppCellfacs-Trachea-18m-Mesenchymal-myofibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RHCG SORBS2 GPRC5C IRAG1 SLC7A4

1.08e-0418811159d384c0934f1461bc37b1f83e0877d7bee2116ee
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

PALD1 MAGEL2 PRAG1 SLC1A7 DACT3

1.08e-041881115c90669b51e1902fe7726555290c91c92a911df83
ToppCellfacs-Trachea-nan-3m-Mesenchymal-smooth_muscle_cell_of_trachea|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORBS2 ANK3 MARK1 ADAM11 IRAG1

1.08e-041881115794fc1d9a726945c42f7eac221eed938309b47a9
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

PALD1 MYCT1 ZDHHC14 BCAR1 MICAL3

1.08e-041881115aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PALD1 JCAD F2RL3 ZDHHC14 FRY

1.11e-041891115b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCellControl|World / Disease state, Lineage and Cell class

DOCK4 DMXL2 MYO9B NCOR2 MMP14

1.11e-041891115fb8dddd3b901081c6bb9ed6f32dafc5cce5f30be
ToppCellLA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

ZDHHC14 ETV6 IRAG1 NEDD9 FRY

1.11e-0418911156b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KIF26A MYT1 PCDHA1 SKOR2 BSN

1.11e-041891115cceca3d14dd559bbb2cb4b81ea12c2b62d18ee49
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

SORBS2 ANK3 ZDHHC14 JPH1 MICAL3

1.14e-04190111593c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCellrenal_medulla_nuclei-Adult_normal_reference|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK4 LRRC37A3 PER1 NEDD9 FRY

1.14e-041901115f1363f7806cfc4f14fbc1b0e8dac2de813a88eee
ToppCellCOVID-19-kidney-VWF+PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

DOCK4 PALD1 JCAD F2RL3 YES1

1.16e-0419111152f00d0b7b2ffce8eb3eb5bbae49a0d425b23c982
ToppCellhuman_hepatoblastoma-Tumor_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

PARD3B MED13L PRAG1 NEDD9 MED13

1.19e-041921115916fbec1c7ab7969bda711886ac88e877e30c280
ToppCellfacs-Marrow-KLS-3m-Hematologic-MPP_Fraction_A_+_HSC|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP32 F2RL3 MYCT1 ETV6 SLC7A4

1.19e-041921115959c28d28397bc0b9d3970d1fe3293d2750e63d4
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SORBS2 GPRC5C SMOC2 IRAG1 RAI2

1.19e-041921115fee99ca7e658963acf968aa724ef8c96cfc00a5d
ToppCellLPS-IL1RA+antiTNF-Endothelial|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

JCAD MYCT1 ZDHHC14 YES1 CTNND2

1.19e-04192111504f5a2e3dd6beff027b89d66eefdd92036e041af
DrugRemoxipride Hydrochloride [73220-03-8]; Up 200; 9.8uM; HL60; HT_HG-U133A

ANK3 MYO9B MARK1 ZDHHC14 PLEKHA6 SH2B1 PRR7 MMP14 PLXNA1

4.20e-0719510993124_UP
DrugGossypol [303-45-7]; Down 200; 7.8uM; MCF7; HT_HG-U133A

DMXL2 ATN1 MYO9B ZDHHC14 PLEKHA6 NCOR2 UBTF RAI2

5.09e-0619810984762_DN
Diseaseplexin-A1 measurement

MMP14 PLXNA1

3.97e-0531082EFO_0801892
Diseasecortical surface area measurement

PALD1 ANK3 MYO9B MYT1 PARD3B PSTPIP1 MED13L SMOC2 IRAG1 UBTF RALBP1 PAFAH1B1 PCBP2 BANK1

3.98e-04134510814EFO_0010736
Diseaseasthma

ERBB2 DMXL2 MYO9B MYT1 MUC16 ETV6 IRAG1 PRAG1 ILDR1 CTNND2

4.42e-0475110810MONDO_0004979
Diseasenon-alcoholic fatty liver disease, type 2 diabetes mellitus

MPP2 ETV6 NEDD9 TJP2

7.27e-041101084EFO_0003095, MONDO_0005148
Diseaserheumatoid arthritis (implicated_via_orthology)

ZAP70 MMP14

8.55e-04121082DOID:7148 (implicated_via_orthology)
Diseasepost-traumatic stress disorder

DOCK4 ZDHHC14 PCDHA1 UST DPY19L2P1

9.01e-042021085EFO_0001358
DiseaseCarcinogenesis

ERBB2 PAFAH1B1

1.01e-03131082C0596263
Diseaseovarian neoplasm

DOK1 ERBB2 MUC16 NR5A1

1.51e-031341084C0919267
DiseaseMalignant neoplasm of ovary

DOK1 ERBB2 MUC16 NR5A1

1.64e-031371084C1140680
Diseasesporadic amyotrophic lateral sclerosis

ANK3 ZFYVE26 CTNND2 PLXNA1

1.78e-031401084EFO_0001357
Diseasepeak expiratory flow

JCAD ANK3 IRAG1 UST FRY MICAL3 MMP14

2.41e-034981087EFO_0009718
DiseaseAutistic Disorder

DOCK4 MAGEL2 MARK1 RNF8 PER1

2.77e-032611085C0004352
DiseaseCorneal astigmatism

MED13L SMOC2 CTNND2

2.87e-03771083EFO_1002040
Diseaseschizophrenia (is_implicated_in)

ATN1 ANK3 CTNND2

2.97e-03781083DOID:5419 (is_implicated_in)
DiseaseAbnormality of refraction

MPP2 JCAD ARHGAP32 ANK3 PCDHA1 FRY TJP2 CTNND2

3.36e-036731088HP_0000539

Protein segments in the cluster

PeptideGeneStartEntry
PRPTSIPPKEETTPY

BANK1

616

Q8NDB2
PTVPLPSETDGYVAP

ERBB2

1116

P04626
SISYTGPTERPPNEP

AGK

251

Q53H12
VLDKDSPVYPGPARP

CDX1

6

P47902
SSDTQGPKVTYIPPP

DDX4

236

Q9NQI0
RPEGVYDIPPTCTKP

NEDD9

256

Q14511
GDVPSERPFYPPTLV

ALDH16A1

371

Q8IZ83
VYDVPPSVEKGLPPS

BCAR1

286

P56945
YDVPPSVSKDVPDGP

BCAR1

306

P56945
TEGFKYPRPSSVPPS

GYS2

631

P54840
KRAPSPGAYKTATPP

ATN1

641

P54259
PTSPPTGETERYKGP

ADAM11

716

O75078
PFDGSPKITYSTPPV

ERVV-2

266

B6SEH9
KDATPPPVPAERPSY

DMXL2

2431

Q8TDJ6
SVPEPGELKPALRPY

SLC7A4

451

O43246
SVESPYSKSGPALPP

CTNND2

511

Q9UQB3
VEIPPSSPNPDGKGY

ASXL3

1796

Q9C0F0
SRPSVPDKPKNPTYG

MMP14

301

P50281
RKSEPPPETLYDSGA

RAI2

351

Q9Y5P3
TKFPGLYRTGEPSPP

RALBP1

36

Q15311
PRPPEKYALSGHRSP

PAFAH1B1

96

P43034
KGYAPPPSDPLRTHV

PARPBP

236

Q9NWS1
SEPPPGKEGPLTYRF

PALD1

586

Q9ULE6
KQERISYTPPESPVP

ETV6

11

P41212
YPGLPEPSKVTSPVV

MUC16

8956

Q8WXI7
PPPPSRDLTEAYKTQ

NCOR2

1386

Q9Y618
AKSTGTEPPAPVPYQ

PSTPIP1

271

O43586
LESPPKGATIPYHPS

PCBP4

171

P57723
PPKGSYPRPTELRVA

PARD3B

1121

Q8TEW8
PSPSKRPYGASPARE

DPY19L2P1

16

Q6NXN4
STDTPYPGSLPPELR

LRRC37A3

186

O60309
TPVDRSKGPEPSFPT

MICAL3

1341

Q7RTP6
PGVSATPPKSPVYLD

MAP1S

936

Q66K74
YGSEESPEPLPIPTL

MED13L

1371

Q71F56
SSPPAEAPKPPVYSR

MAGEL2

11

Q9UJ55
STDTPYPGSLPPELR

LRRC37A2

186

A6NM11
STDTPYPGSLPPELR

LRRC37A

186

A6NMS7
PSYPPIVTVPKSIDD

MTMR9

156

Q96QG7
PETPLRAEPPSSYKV

GINM1

226

Q9NU53
SYPAEPREPQESPKI

JCAD

991

Q9P266
YRKGTTPPRSPEASP

JPH1

456

Q9HDC5
SSVPPAEGPVYLGKP

BSN

2271

Q9UPA5
VPPRYKEPTTDEAPS

FSIP2

5866

Q5CZC0
PFDGSPKITYSTPPV

ERVV-1

266

B6SEH8
DPLQYPETTPKGLAP

IRAG1

286

Q9Y6F6
PDPAPDAYRPVGLTK

PER1

766

O15534
TGPVEDNEKCYPPPS

PLXNA1

86

Q9UIW2
SPPLTTGPPEFERVY

LTC4S

36

Q16873
EEKPPSYRSLDITPG

ILDR1

506

Q86SU0
YERKSGKQGSSPPPP

MARCHF6

891

O60337
GPALPSPYSKVTAPR

KIF26A

1606

Q9ULI4
SKTYETPPPSPGLDP

MPP2

136

Q14168
PSDKIYPPSGSPEEN

ARHGAP32

1241

A7KAX9
PYRPKPSSSPVIFAG

PCBP2

181

Q15366
PPTEGAYVPGKPTLV

PCDHA1

726

Q9Y5I3
EPPPPYSEVLTDTRG

PRR7

161

Q8TB68
DEPVAAKRPVSPYSG

GPRC5C

346

Q9NQ84
DDSTPSILPAPRGYP

F2RL3

36

Q96RI0
VQGEEKYPKTSPPPT

CEFIP

106

Q711Q0
PGYDPDTVASPKPVS

HECTD1

1336

Q9ULT8
PSEPRGIYASERPKS

DACT3

151

Q96B18
AVPSGPPKYPTAERE

DACT3

436

Q96B18
PVPVPSYGGEEPVRK

DOCK4

1881

Q8N1I0
TDDYAVPPPRSTKPL

DOK1

406

Q99704
DLTPPPEVVYKSEPG

SLC1A7

201

O00341
SGKVYPTVHTSPPPE

CACNA1G

586

O43497
DSPPRQAPRSAPYKG

CCNL2

426

Q96S94
AYIPGKPSPIPEVSE

ANK3

3191

Q12955
ETGEPYRLSPEPTPL

EIF4G1

306

Q04637
AGPSIPPAVSYTKRP

MARK1

426

Q9P0L2
PGYSPGFRKPPEVVR

DONSON

6

Q9NYP3
PVPYPGLSTVPSDET

KLF17

176

Q5JT82
YIKPPVPPASGTHRE

FRY

31

Q5TBA9
PNEEPKVATAYRPPA

EIF2A

436

Q9BY44
PTSAYPERKGSPTPG

FAM83H

871

Q6ZRV2
SQTEEERKTPFYPPP

SLC13A5

381

Q86YT5
PTSPDYSLDSPGPEK

SASH3

111

O75995
KYRPEAPGPSVSLSP

SCNM1

131

Q9BWG6
SVYRPRLSKPEEPPS

PRIMPOL

26

Q96LW4
EPYPSVVDPTDPKTL

PARP6

356

Q2NL67
EIPYPTEPARAGLPS

PANX2

571

Q96RD6
SAPYPPLDTPETATG

SH2B1

491

Q9NRF2
PAFPGRAIKSEYPEP

NR5A1

186

Q13285
EPLPPPYSLREVKVS

TPSG1

171

Q9NRR2
EPSKTTGAPIYPGFP

RNF8

211

O76064
HKPPSVPEEYALTSP

NHSL2

886

Q5HYW2
GLSTPPPPAYESIIK

MYCT1

216

Q8N699
PKINFSGPDYPSIRP

PNLDC1

406

Q8NA58
SYGTDESPEPLPIPT

MED13

1321

Q9UHV7
RPIHPSKAPNYPTEG

NIF3L1

151

Q9GZT8
TKGAEDYPDPPIPHS

SORBS2

1001

O94875
SPAKDAYPETGPDAP

CMTM1

151

Q8IZ96
APPTLPGRDEPYTKQ

CLCA4

106

Q14CN2
DTRDDPYRPAKPVPT

RIOK3

136

O14730
TYLDDHGPPPSKVLP

UST

86

Q9Y2C2
RRSISSPKVPPYPEV

PLEKHA6

501

Q9Y2H5
GYTPEPARITSPDKP

ZAP70

291

P43403
SSRPPEPQKAPSRPY

TJP2

1136

Q9UDY2
LPLYPDPSRVPGTKT

nan

6

Q6ZSR9
PLDTVYPAPEKRPSA

SEC16A

696

O15027
YPAPEKRPSARTQGP

SEC16A

701

O15027
GRPIPGTSTRYEQPK

SMOC2

266

Q9H3U7
TYGRPPDSVPVDSFP

PXK

346

Q7Z7A4
SVRGKYSDDTPLPTP

DHX38

256

Q92620
FPKDRSGIETFSPPP

PRAG1

701

Q86YV5
GPRSYPVIPVPSKGS

SKOR2

376

Q2VWA4
YIPEDPTFKPSGPSV

RHCG

446

Q9UBD6
TSSGGYRPPPRTKEV

ZDHHC14

141

Q8IZN3
PIAAPLVPYPEKSSE

ZNF597

81

Q96LX8
GASYEPTILGKPPTP

XKR5

366

Q6UX68
DKFDGRPTKPPPNSY

UBTF

291

P17480
PSHVKAEPKDSYPGP

ZFYVE26

646

Q68DK2
SPAIKYRPENTPEPV

YES1

11

P07947
YPVPASKRPPLRGVE

MSC

21

O60682
GQPPGAKRRYSDPPT

MYO9B

2131

Q13459
PELRGPESPSPKPEY

MYT1

326

Q01538
PESPSPKPEYSVIVE

MYT1

331

Q01538