Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF355P ZNF12 ZNF765 ZNF383 ZNF136 ZNF492 ZNF845 ZNF140 ZNF600 ZNF676 ZNF728 ZNF92 ZNF254 ZNF813 ZNF611 ZNF479 ZNF808 ZNF616 ZFP14 ZNF766 ZNF701 ZNF761 ZNF860 ZNF699 ZNF91 ADNP ZBTB11 ZNF107 ZNF98 ZNF354B ZNF850 ZNF714 ZNF730 ZNF354C ZNF682 ZNF284 ZNF124 ZNF445	9.08e-29	1412	61	38	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF355P ZNF12 ZNF765 ZNF383 ZNF136 ZNF492 ZNF845 ZNF140 ZNF600 ZNF676 ZNF728 ZNF92 ZNF254 ZNF813 ZNF611 ZNF479 ZNF808 ZNF616 ZFP14 ZNF766 ZNF701 ZNF761 ZNF860 ZNF699 ZNF91 ADNP ZBTB11 ZNF107 ZNF98 ZNF354B ZNF850 ZNF714 ZNF730 ZNF354C ZNF682 ZNF284 ZNF124 ZNF445	3.03e-28	1459	61	38	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF355P ZNF12 ZNF765 ZNF383 ZNF136 ZNF492 ZNF845 ZNF140 ZNF600 ZNF676 ZNF728 ZNF92 ZNF254 ZNF813 ZNF611 ZNF479 ZNF808 ZNF616 ZFP14 ZNF766 ZNF701 ZNF761 ZNF860 ZNF699 ZNF91 ZBTB11 ZNF107 ZNF98 ZNF354B ZNF850 ZNF714 ZNF730 ZNF354C ZNF682 ZNF284 ZNF445	4.76e-28	1244	61	36	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF355P ZNF12 ZNF765 ZNF383 ZNF136 ZNF492 ZNF845 ZNF140 ZNF600 ZNF676 ZNF728 ZNF92 ZNF254 ZNF813 ZNF611 ZNF479 ZNF808 ZNF616 ZFP14 ZNF766 ZNF701 ZNF761 ZNF860 ZNF699 ZNF91 ZBTB11 ZNF107 ZNF98 ZNF354B ZNF850 ZNF714 ZNF730 ZNF354C ZNF682 ZNF284 ZNF445	1.01e-27	1271	61	36	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF845 ZNF600 ZNF808 ZNF699 ZNF91 ZNF107 ZNF850 ZNF682 ZNF445	4.76e-05	560	61	9	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF845 ZNF600 ZNF808 ZNF699 ZNF91 ZNF107 ZNF850 ZNF682 ZNF445	5.17e-05	566	61	9	GO:0001216
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZNF140 ZNF699 ZNF91 ZNF107 ZNF354C ZNF682	4.28e-04	320	61	6	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZNF140 ZNF699 ZNF91 ZNF107 ZNF354C ZNF682	4.72e-04	326	61	6	GO:0001217
GeneOntologyMolecularFunction	NAD+-protein poly-ADP-ribosyltransferase activity	TNKS TNKS2	3.30e-03	28	61	2	GO:0003950
GeneOntologyMolecularFunction	NAD+-protein ADP-ribosyltransferase activity	TNKS TNKS2	3.78e-03	30	61	2	GO:1990404
GeneOntologyBiologicalProcess	negative regulation of cholangiocyte proliferation	LIMS1 LIMS2	2.58e-05	3	61	2	GO:1904055
Domain	zf-C2H2_6	ZNF12 ZNF765 ZNF136 ZNF492 ZNF845 ZNF140 ZNF600 ZNF676 ZNF728 ZNF92 ZNF813 ZNF611 ZNF479 ZNF808 ZNF616 ZFP14 ZNF766 ZNF701 ZNF761 ZNF860 ZNF699 ZNF91 ZBTB11 ZNF107 ZNF98 ZNF354B ZNF850 ZNF714 ZNF730 ZNF354C ZNF682 ZNF284 ZNF445	1.36e-43	314	59	33	PF13912
Domain	KRAB	ZNF12 ZNF765 ZNF383 ZNF136 ZNF492 ZNF845 ZNF140 ZNF676 ZNF728 ZNF92 ZNF254 ZNF813 ZNF611 ZNF479 ZNF808 ZNF616 ZFP14 ZNF766 ZNF701 ZNF761 ZNF860 ZNF699 ZNF91 ZNF98 ZNF354B ZNF738 ZNF850 ZNF714 ZNF730 ZNF354C ZNF682 ZNF284 ZNF124 ZNF445	1.64e-43	358	59	34	PS50805
Domain	KRAB	ZNF12 ZNF765 ZNF383 ZNF136 ZNF492 ZNF845 ZNF140 ZNF676 ZNF728 ZNF92 ZNF254 ZNF813 ZNF611 ZNF479 ZNF808 ZNF616 ZFP14 ZNF766 ZNF701 ZNF761 ZNF860 ZNF699 ZNF91 ZNF98 ZNF354B ZNF738 ZNF850 ZNF714 ZNF730 ZNF354C ZNF682 ZNF284 ZNF124 ZNF445	4.74e-43	369	59	34	SM00349
Domain	KRAB	ZNF12 ZNF765 ZNF383 ZNF136 ZNF492 ZNF845 ZNF140 ZNF676 ZNF728 ZNF92 ZNF254 ZNF813 ZNF611 ZNF479 ZNF808 ZNF616 ZFP14 ZNF766 ZNF701 ZNF761 ZNF860 ZNF699 ZNF91 ZNF98 ZNF354B ZNF738 ZNF850 ZNF714 ZNF730 ZNF354C ZNF682 ZNF284 ZNF124 ZNF445	5.22e-43	370	59	34	IPR001909
Domain	zf-C2H2	ZNF12 ZNF765 ZNF383 ZNF136 ZNF492 ZNF845 ZNF140 ZNF600 ZNF676 ZNF728 ZNF92 ZNF254 ZNF813 ZNF611 ZNF479 ZNF808 ZNF616 ZFP14 ZNF766 ZNF701 ZNF761 ZNF860 ZNF699 ZNF91 ADNP ZBTB11 ZNF107 ZNF98 ZNF354B ZNF850 ZNF714 ZNF730 ZNF354C ZNF682 ZNF702P ZNF284 ZNF124 ZNF445	4.01e-40	693	59	38	PF00096
Domain	KRAB	ZNF12 ZNF765 ZNF383 ZNF136 ZNF492 ZNF845 ZNF140 ZNF728 ZNF92 ZNF254 ZNF813 ZNF611 ZNF479 ZNF808 ZNF616 ZFP14 ZNF766 ZNF701 ZNF761 ZNF860 ZNF699 ZNF91 ZNF98 ZNF354B ZNF738 ZNF850 ZNF730 ZNF354C ZNF682 ZNF284 ZNF124 ZNF445	8.28e-40	358	59	32	PF01352
Domain	Znf_C2H2/integrase_DNA-bd	ZNF12 ZNF765 ZNF383 ZNF136 ZNF492 ZNF845 ZNF140 ZNF600 ZNF676 ZNF728 ZNF92 ZNF254 ZNF813 ZNF611 ZNF479 ZNF808 ZNF616 ZFP14 ZNF766 ZNF701 ZNF761 ZNF860 ZNF699 ZNF91 ADNP ZBTB11 ZNF107 ZNF98 ZNF354B ZNF850 ZNF714 ZNF730 ZNF354C ZNF682 ZNF284 ZNF124 ZNF445	2.00e-38	694	59	37	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF12 ZNF765 ZNF383 ZNF136 ZNF492 ZNF845 ZNF140 ZNF600 ZNF676 ZNF728 ZNF92 ZNF254 ZNF813 ZNF611 ZNF479 ZNF808 ZNF616 ZFP14 ZNF766 ZNF701 ZNF761 ZNF860 ZNF699 ZNF91 ADNP ZBTB11 ZNF107 ZNF98 ZNF354B ZNF850 ZNF714 ZNF730 ZNF354C ZNF682 ZNF702P ZNF284 ZNF124 ZNF445	2.86e-38	775	59	38	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF12 ZNF765 ZNF383 ZNF136 ZNF492 ZNF845 ZNF140 ZNF600 ZNF676 ZNF728 ZNF92 ZNF254 ZNF813 ZNF611 ZNF479 ZNF808 ZNF616 ZFP14 ZNF766 ZNF701 ZNF761 ZNF860 ZNF699 ZNF91 ADNP ZBTB11 ZNF107 ZNF98 ZNF354B ZNF850 ZNF714 ZNF730 ZNF354C ZNF682 ZNF702P ZNF284 ZNF124 ZNF445	3.16e-38	777	59	38	PS00028
Domain	Znf_C2H2	ZNF12 ZNF765 ZNF383 ZNF136 ZNF492 ZNF845 ZNF140 ZNF600 ZNF676 ZNF728 ZNF92 ZNF254 ZNF813 ZNF611 ZNF479 ZNF808 ZNF616 ZFP14 ZNF766 ZNF701 ZNF761 ZNF860 ZNF699 ZNF91 ADNP ZBTB11 ZNF107 ZNF98 ZNF354B ZNF850 ZNF714 ZNF730 ZNF354C ZNF682 ZNF702P ZNF284 ZNF124 ZNF445	1.21e-37	805	59	38	IPR007087
Domain	ZnF_C2H2	ZNF12 ZNF765 ZNF383 ZNF136 ZNF492 ZNF845 ZNF140 ZNF600 ZNF676 ZNF728 ZNF92 ZNF254 ZNF813 ZNF611 ZNF479 ZNF808 ZNF616 ZFP14 ZNF766 ZNF701 ZNF761 ZNF860 ZNF699 ZNF91 ADNP ZBTB11 ZNF107 ZNF98 ZNF354B ZNF850 ZNF714 ZNF730 ZNF354C ZNF682 ZNF702P ZNF284 ZNF124 ZNF445	1.40e-37	808	59	38	SM00355
Domain	-	ZNF12 ZNF765 ZNF383 ZNF136 ZNF492 ZNF845 ZNF140 ZNF600 ZNF676 ZNF728 ZNF92 ZNF254 ZNF813 ZNF611 ZNF479 ZNF808 ZNF616 ZFP14 ZNF766 ZNF701 ZNF761 ZNF860 ZNF699 ZNF91 ZBTB11 ZNF107 ZNF98 ZNF354B ZNF850 ZNF714 ZNF730 ZNF354C ZNF682 ZNF284 ZNF124 ZNF445	4.01e-37	679	59	36	3.30.160.60
Domain	Znf_C2H2-like	ZNF12 ZNF765 ZNF383 ZNF136 ZNF492 ZNF845 ZNF140 ZNF600 ZNF676 ZNF728 ZNF92 ZNF254 ZNF813 ZNF611 ZNF479 ZNF808 ZNF616 ZFP14 ZNF766 ZNF701 ZNF761 ZNF860 ZNF699 ZNF91 ADNP ZBTB11 ZNF107 ZNF98 ZNF354B ZNF850 ZNF714 ZNF730 ZNF354C ZNF682 ZNF284 ZNF124 ZNF445	3.22e-36	796	59	37	IPR015880
Domain	PINCH	LIMS1 LIMS2	2.94e-05	3	59	2	IPR017351
Domain	Poly(ADP-ribose)pol_cat_dom	TNKS TNKS2	1.29e-03	17	59	2	IPR012317
Domain	PARP_CATALYTIC	TNKS TNKS2	1.29e-03	17	59	2	PS51059
Domain	PARP	TNKS TNKS2	1.29e-03	17	59	2	PF00644
Domain	-	TNKS TNKS2	1.29e-03	17	59	2	3.90.228.10
Domain	WGR_domain	TNKS TNKS2	2.59e-03	24	59	2	IPR008893
Domain	SAM_2	TNKS TNKS2	8.15e-03	43	59	2	PF07647
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF12 ZNF383 ZNF136 ZNF492 ZNF140 ZNF600 ZNF676 RNGTT CAMK2B ZNF92 ZNF254 ZNF611 ZNF479 ZNF616 ZFP14 ZNF701 ZNF761 ZNF860 ZNF699 ZNF354B ZNF738 ZNF714 ZNF730 ZNF354C ZNF682 ZNF124 ZNF445	1.47e-15	1387	48	27	M734
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	ZNF355P ZNF12 ZNF383 ZNF136 ZNF845 ZNF254 ZNF808 ZNF616 ZFP14 ZNF699 ZNF91 ZNF107 ZNF354B ZNF850 ZNF354C ZNF682 ZNF284 ZNF445	2.29e-11	768	48	18	MM14851
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	ZNF355P ZNF12 ZNF383 ZNF136 ZNF845 RNGTT ZNF254 ZNF808 ZNF616 ZFP14 ZNF699 ZNF91 ZNF107 ZNF354B ZNF850 ZNF354C ZNF682 ZNF284 ZNF445	2.88e-10	1022	48	19	MM15436
Pathway	REACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS	ZNF355P ZNF254 ZNF616 ZNF699	3.82e-05	56	48	4	MM17236
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF383 ZNF136 ZNF845 ZNF140 ZNF728 ZNF92 ZNF813 ZNF611 ZNF766 ZNF701 ZNF699 ZNF91 ZBTB11 ZNF107 ZNF98 ZNF354B ZNF738 ZNF124 ZNF445	3.80e-29	181	61	19	37372979
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF355P ZNF616 ZNF91 ZNF107 ZNF850 ZNF682 ZNF445	2.90e-12	49	61	7	9630514
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF355P ZNF254 ZNF91 ZNF107 ZNF682	1.61e-09	29	61	5	14563677
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF355P ZNF254 ZNF91 ZNF107	1.15e-08	15	61	4	15885501
Pubmed	Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.	ZNF92 ZNF91 ZNF107 ZNF98	1.53e-08	16	61	4	8467795
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	ZNF813 ZNF616 ZNF766 ZNF701 ZNF91 ZNF107 ZNF714 ZNF682	1.21e-06	451	61	8	36168627
Pubmed	Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.	ZNF91 ZNF107 ZNF354C	1.45e-06	13	61	3	19850934
Pubmed	Tankyrase is necessary for canonical Wnt signaling during kidney development.	TNKS TNKS2	3.03e-06	2	61	2	20549720
Pubmed	Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.	TNKS TNKS2	3.03e-06	2	61	2	18612384
Pubmed	Characterization of the human Fc gamma RIIB gene promoter: human zinc-finger proteins (ZNF140 and ZNF91) that bind to different regions function as transcription repressors.	ZNF140 ZNF91	3.03e-06	2	61	2	11470777
Pubmed	Inhibition of Epstein-Barr virus OriP function by tankyrase, a telomere-associated poly-ADP ribose polymerase that binds and modifies EBNA1.	TNKS TNKS2	3.03e-06	2	61	2	15795250
Pubmed	Structural insights into SAM domain-mediated tankyrase oligomerization.	TNKS TNKS2	3.03e-06	2	61	2	27328430
Pubmed	Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy.	TNKS TNKS2	3.03e-06	2	61	2	28723574
Pubmed	LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice.	LIMS1 LIMS2	3.03e-06	2	61	2	33083097
Pubmed	Signaling via PINCH: Functions, binding partners and implications in human diseases.	LIMS1 LIMS2	3.03e-06	2	61	2	27590440
Pubmed	Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling.	TNKS TNKS2	3.03e-06	2	61	2	27494558
Pubmed	Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation.	TNKS TNKS2	3.03e-06	2	61	2	29263426
Pubmed	Regulation of tankyrase activity by a catalytic domain dimer interface.	TNKS TNKS2	3.03e-06	2	61	2	30055800
Pubmed	Molecular insights on TNKS1/TNKS2 and inhibitor-IWR1 interactions.	TNKS TNKS2	3.03e-06	2	61	2	24291818
Pubmed	Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity.	TNKS TNKS2	3.03e-06	2	61	2	24116873
Pubmed	Requirement for PINCH in skeletal myoblast differentiation.	LIMS1 LIMS2	3.03e-06	2	61	2	36385586
Pubmed	Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients.	TNKS TNKS2	3.03e-06	2	61	2	18026951
Pubmed	Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis.	LIMS1 LIMS2	3.03e-06	2	61	2	24058607
Pubmed	Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice.	LIMS1 LIMS2	3.03e-06	2	61	2	31723057
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZNF355P ZNF254 ZNF850	5.73e-06	20	61	3	2542606
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZNF355P ZNF254 ZNF850	5.73e-06	20	61	3	7479878
Pubmed	Tankyrase inhibition aggravates kidney injury in the absence of CD2AP.	TNKS TNKS2	9.07e-06	3	61	2	27441654
Pubmed	Consequences of loss of PINCH2 expression in mice.	LIMS1 LIMS2	9.07e-06	3	61	2	16317048
Pubmed	Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.	TNKS TNKS2	9.07e-06	3	61	2	33361107
Pubmed	Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration.	LIMS1 LIMS2	9.07e-06	3	61	2	12167643
Pubmed	Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation.	TNKS TNKS2	9.07e-06	3	61	2	32442396
Pubmed	Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex.	TNKS TNKS2	9.07e-06	3	61	2	33923443
Pubmed	Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.	TNKS TNKS2	9.07e-06	3	61	2	11739745
Pubmed	Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells.	TNKS TNKS2	9.07e-06	3	61	2	26246473
Pubmed	TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression.	TNKS TNKS2	9.07e-06	3	61	2	11454873
Pubmed	Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.	TNKS TNKS2	9.07e-06	3	61	2	21251231
Pubmed	Brief research report: Effects of Pinch deficiency on cartilage homeostasis in adult mice.	LIMS1 LIMS2	9.07e-06	3	61	2	36743414
Pubmed	Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.	TNKS TNKS2	9.07e-06	3	61	2	25939383
Pubmed	A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading.	LIMS1 LIMS2	1.81e-05	4	61	2	11331308
Pubmed	Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death.	TNKS TNKS2	1.81e-05	4	61	2	30260955
Pubmed	PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis.	TNKS TNKS2	1.81e-05	4	61	2	38272024
Pubmed	Poly-ADP ribosylation of p21 by tankyrases promotes p21 degradation and regulates cell cycle progression.	TNKS TNKS2	1.81e-05	4	61	2	36383218
Pubmed	Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14.	TNKS TNKS2	1.81e-05	4	61	2	11278563
Pubmed	E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling.	TNKS TNKS2	1.81e-05	4	61	2	26513298
Pubmed	The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182).	TNKS TNKS2	1.81e-05	4	61	2	11854288
Pubmed	Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages.	ZNF600 PDCD11 ZBTB11	2.46e-05	32	61	3	26142281
Pubmed	Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase).	TNKS TNKS2	3.02e-05	5	61	2	11802774
Pubmed	Tankyrase represses autoinflammation through the attenuation of TLR2 signaling.	TNKS TNKS2	3.02e-05	5	61	2	35362478
Pubmed	The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation.	TNKS TNKS2	3.02e-05	5	61	2	22473005
Pubmed	Dissecting integrin-dependent regulation of neural stem cell proliferation in the adult brain.	LIMS1 LIMS2	3.02e-05	5	61	2	24719101
Pubmed	Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs.	TNKS TNKS2	4.52e-05	6	61	2	34128958
Pubmed	Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.	TNKS TNKS2	4.52e-05	6	61	2	19759537
Pubmed	Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.	TNKS TNKS2	4.52e-05	6	61	2	21799911
Pubmed	Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles.	TNKS TNKS2	4.52e-05	6	61	2	10988299
Pubmed	Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs.	TNKS TNKS2	4.52e-05	6	61	2	26845027
Pubmed	PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions.	LIMS1 LIMS2	4.52e-05	6	61	2	12651156
Pubmed	The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons.	ZNF355P ZNF254	4.52e-05	6	61	2	30846446
Pubmed	Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins.	ZNF136 ZNF140	4.52e-05	6	61	2	7649249
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	ZNF92 TNKS TNKS2 ZNF445	6.04e-05	120	61	4	31413325
Pubmed	Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth.	TNKS TNKS2	6.32e-05	7	61	2	25547115
Pubmed	Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling.	TNKS TNKS2	6.32e-05	7	61	2	31554794
Pubmed	RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.	TNKS TNKS2	6.32e-05	7	61	2	21478859
Pubmed	Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism.	TNKS TNKS2	6.32e-05	7	61	2	22153076
Pubmed	Mutations in the paxillin-binding site of integrin-linked kinase (ILK) destabilize the pseudokinase domain and cause embryonic lethality in mice.	LIMS1 LIMS2	8.42e-05	8	61	2	23658024
Pubmed	The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.	ZNF92 ZNF91	8.42e-05	8	61	2	2023909
Pubmed	Characterization of a mouse multigene family that encodes zinc finger structures.	ZNF12 ZFP14	8.42e-05	8	61	2	2452975
Pubmed	Comparative analysis of KRAB zinc finger proteins in rodents and man: evidence for several evolutionarily distinct subfamilies of KRAB zinc finger genes.	ZNF254 ZNF699	1.08e-04	9	61	2	10360839
Pubmed	Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis.	TNKS TNKS2	1.08e-04	9	61	2	19766477
Pubmed	Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.	TNKS TNKS2	1.08e-04	9	61	2	12080061
Pubmed	Functional analysis of the SRY-KRAB interaction in mouse sex determination.	ZNF91 ZNF107	1.35e-04	10	61	2	18588511
Pubmed	Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.	ZNF91 ZNF107	1.65e-04	11	61	2	15469996
Pubmed	Genetic variants in eleven telomere-associated genes and the risk of incident cardio/cerebrovascular disease: The Women's Genome Health Study.	TNKS TNKS2	1.65e-04	11	61	2	20937264
Pubmed	Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci.	ZNF355P ZNF254 ZNF850	1.72e-04	61	61	3	8662221
Pubmed	Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.	TNKS TNKS2	2.72e-04	14	61	2	35733260
Pubmed	Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality.	LIMS1 LIMS2	2.72e-04	14	61	2	19652092
Pubmed	High-throughput RNAi screening reveals novel regulators of telomerase.	TNKS TNKS2	3.57e-04	16	61	2	21531765
Pubmed	Family-wide analysis of poly(ADP-ribose) polymerase activity.	TNKS TNKS2	3.57e-04	16	61	2	25043379
Pubmed	USP25 regulates Wnt signaling by controlling the stability of tankyrases.	TNKS TNKS2	3.57e-04	16	61	2	28619731
Pubmed	Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.	ZNF136 ZNF140	4.05e-04	17	61	2	7557990
Pubmed	Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system.	LIMS1 LIMS2	5.08e-04	19	61	2	19349584
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	LIMS1 ZNF254 ZNF616 ZNF91 ZNF354C ZNF445 LIMS2	5.22e-04	808	61	7	20412781
Pubmed	Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.	ZNF12 ZNF136	6.22e-04	21	61	2	7865130
Pubmed	Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary development†.	FST VCAM1	6.22e-04	21	61	2	32301970
Pubmed	The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification.	ZNF765 ZNF136	6.83e-04	22	61	2	31403225
Pubmed	The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin.	TNKS TNKS2	6.83e-04	22	61	2	27521426
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZNF12 ZNF136 ZNF845 ZNF813 ADNP ZBTB11	6.84e-04	608	61	6	36089195
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ZNF12 ZNF765 ZNF845 FAM111A ZNF813 ZNF808 TNKS ZNF850	1.16e-03	1203	61	8	29180619
Interaction	TRIM28 interactions	ZNF12 ZNF765 ZNF383 ZNF136 ZNF492 ZNF845 ZNF140 LIMS1 ZNF600 ZNF728 ZNF92 ZNF254 ZNF813 ZNF611 PDCD11 ZNF808 ZNF616 ZNF766 ZNF701 ZNF761 ZNF699 ZNF91 ZBTB11 ZNF107 ZNF98 ZNF354B ZNF738 ZNF354C ZNF682 VCAM1 ZNF284 ZNF124 ZNF445	6.01e-22	1474	61	33	int:TRIM28
Interaction	LTBP2 interactions	ZNF12 ZNF765 ZNF136 ZNF92 ZNF254 ZNF611 ZNF766 ZNF107 ZNF714	3.97e-12	85	61	9	int:LTBP2
Interaction	PURG interactions	ZNF492 ZNF845 FAM111A ZNF92 ZNF813 PDCD11 ZNF616 ZNF91 ZBTB11 ZNF107 ZNF445	6.12e-11	223	61	11	int:PURG
Interaction	ZNF467 interactions	ZNF765 ZNF845 ZNF92 ZNF254 ZNF813 PDCD11 ZNF761 ZNF107 ZNF445	3.28e-09	179	61	9	int:ZNF467
Interaction	CUL9 interactions	ZNF765 ZNF845 ZNF92 ZNF616 ZNF761 ZNF107 ZNF445	8.31e-07	171	61	7	int:CUL9
Interaction	NOTCH2 interactions	ZNF765 ZNF136 ZNF92 ZNF813 ZNF611 ZNF766 ZNF761 ZNF107 ZNF445	4.79e-06	423	61	9	int:NOTCH2
Interaction	ZNF324B interactions	ZNF92 ZNF813 ZBTB11 ZNF107 ZNF445	7.34e-06	89	61	5	int:ZNF324B
Interaction	TRIM44 interactions	ZNF92 ZNF254 ZNF761 ZNF91	6.00e-05	70	61	4	int:TRIM44
Interaction	ZNF223 interactions	ZNF92 ZNF714 ZNF284	1.01e-04	30	61	3	int:ZNF223
Interaction	ARHGAP24 interactions	ZNF813 ZNF616 ZNF766 ZNF701 ZNF91 ZNF107 ZNF714 ZNF682	1.04e-04	486	61	8	int:ARHGAP24
Interaction	RBM4B interactions	ZNF845 FAM111A PDCD11 ZNF701 ZNF761 ZBTB11	1.39e-04	262	61	6	int:RBM4B
Interaction	CELF5 interactions	CELF3 TNKS TNKS2	1.91e-04	37	61	3	int:CELF5
Interaction	ZNF479 interactions	ZNF254 ZNF479	2.49e-04	8	61	2	int:ZNF479
Cytoband	19p12	ZNF492 ZNF676 ZNF728 ZNF254 ZNF91 ZNF98 ZNF738 ZNF714 ZNF730 ZNF682	4.16e-17	90	61	10	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF492 ZNF676 ZNF728 ZNF254 ZNF91 ZNF98 ZNF738 ZNF714 ZNF730 ZNF682	9.69e-16	122	61	10	chr19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF765 ZNF383 ZNF845 ZNF600 SIPA1L3 ZNF813 ZNF611 ZNF808 ZNF616 ZFP14 ZNF766 ZNF701 ZNF761 ZNF850 ZNF702P ZNF284	2.62e-12	1192	61	16	chr19q13
Cytoband	19q13.41	ZNF600 ZNF611 ZNF808 ZNF616 ZNF766 ZNF701 ZNF702P	1.26e-11	78	61	7	19q13.41
Cytoband	19q13.42	ZNF765 ZNF845 ZNF813 ZNF761	2.42e-05	125	61	4	19q13.42
Cytoband	19q13.12	ZNF383 ZFP14 ZNF850	1.25e-04	72	61	3	19q13.12
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF12 ZNF765 ZNF383 ZNF136 ZNF492 ZNF845 ZNF140 ZNF600 ZNF676 ZNF728 ZNF92 ZNF254 ZNF813 ZNF611 ZNF479 ZNF808 ZNF616 ZFP14 ZNF766 ZNF701 ZNF761 ZNF860 ZNF699 ZNF91 ZBTB11 ZNF107 ZNF98 ZNF354B ZNF850 ZNF714 ZNF730 ZNF354C ZNF682 ZNF284 ZNF124 ZNF445	2.81e-39	718	51	36	28
GeneFamily	LIM zinc finger domain containing\|LIM domain containing	LIMS1 LIMS2	4.66e-05	4	51	2	1163
GeneFamily	Zinc fingers\|Zinc fingers PARP-type\|Poly(ADP-ribose) polymerases	TNKS TNKS2	1.03e-03	17	51	2	684
Coexpression	MIKKELSEN_NPC_ICP_WITH_H3K4ME3	ZNF355P FAM111A ARHGEF9 ZNF254 ZNF699 ZNF91 ZNF107 ZNF354B ZNF682 VCAM1	2.08e-07	497	61	10	MM863
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8\|TCGA-Bladder / Sample_Type by Project: Shred V9	ZNF92 ZNF254 ZNF107 ZNF738 ZNF714 ZNF682	5.93e-08	150	61	6	1aa9320d97ff10994ea024751790524fe133aba9
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Papillary-5\|TCGA-Stomach / Sample_Type by Project: Shred V9	ZNF136 ZNF492 ZNF98 ZNF730 ZNF682	4.45e-07	111	61	5	eb737146969b70c619649f244998d4183237c763
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Papillary_Adenocarcinoma-4\|TCGA-Lung / Sample_Type by Project: Shred V9	ZNF676 ZNF728 ZNF479 ZNF98	1.64e-05	111	61	4	bcecf3498a5fbd52dcdf56e68858b2da39d96ba9
Drug	vinylene	ZNF492 LIMS1 ARHGEF9 ZNF91 ZNF107 ZNF98 ZNF445	3.64e-06	245	60	7	CID000006326
Disease	pulmonary embolism	ZNF808 ZNF701	9.96e-04	25	55	2	EFO_0003827
Disease	hypertension, white matter hyperintensity measurement	TNKS ZNF107	6.00e-03	62	55	2	EFO_0000537, EFO_0005665

Protein segments in the cluster

Peptide	Gene	Start	Entry
IHTGEKLYKCGECEK	ZNF354C	321	Q86Y25
VEKKLTYKCIHCLGV	ADNP	656	Q9H2P0
LTVIKDKYTGLHKGC	CELF3	36	Q5SZQ8
HLKDICEGYLKQCRK	ARHGEF9	121	O43307
CHNREKAKGLGKYIC	LIMS2	126	Q7Z4I7
KAKGLGKYICQRCHL	LIMS2	131	Q7Z4I7
KEGIKYIKLQCKGHG	RNGTT	81	O60942
KCACYKIVGALLHFG	MYH7B	391	A7E2Y1
IGLAYEGKCIKAKSC	FST	231	P19883
TDGKIKILCHKYLIG	CENPL	316	Q8N0S6
CVKFYIHAIGIGKCK	FAM111A	181	Q96PZ2
IYLKLSEDHKGKSCG	OTOGL	241	Q3ZCN5
CVKLCTGHEYAAKII	CAMK2B	31	Q13554
YLCTVTCGHKKLEKG	VCAM1	381	P19320
EQGLCRKHKVGILYC	SIPA1L3	616	O60292
KARGLGKYICQKCHA	LIMS1	126	P48059
VCDLTKVKLKYCGVH	PHAF1	81	Q9BSU1
VYSECGLHKKAILCL	CLHC1	426	Q8NHS4
IHLGAKQYKCDVCGK	ZNF845	236	Q96IR2
IHTGEKLYKCNECGK	ZNF845	516	Q96IR2
KYHIGDEVKCRVLLC	PDCD11	496	Q14690
GKKCLDFRKIYAVCH	WFDC6	66	Q9BQY6
ILHTGENLYKCKECG	ZNF107	236	Q9UII5
IHAGEKHYKCEKCGK	ZNF738	281	Q8NE65
IIHTGEKLYKCEECG	ZNF714	416	Q96N38
CQVCGKTFIYKHGLK	ZBTB11	681	O95625
IIHTEGKSYKCEKCG	ZNF92	501	Q03936
IHLADKYKCDVCGKL	ZNF761	236	Q86XN6
KIIHTGEKRYKCEEC	ZNF676	496	Q8N7Q3
HTGEKRYKCIECGKA	ZNF616	711	Q08AN1
IHIGEKSYECKECGK	ZNF383	191	Q8NA42
IHTGEKLYDCKECGK	ZNF136	161	P52737
IIHLGEKKYKCDICG	ZNF702P	26	Q9H963
GKYEICKLLLKHGAD	TNKS	761	O95271
KAIHAGEKLYKCEEC	ZNF728	471	P0DKX0
IHTAVKRYKCEECGK	ZNF682	446	O95780
RLHGGEKSYKCKVCD	ZNF808	671	Q8N4W9
AKGKYEICKLLLQHG	TNKS2	601	Q9H2K2
IHLGEKQYKCDVCGK	ZNF813	236	Q6ZN06
KIIHSGEKIYKCKEC	ZNF730	471	Q6ZMV8
KKCCKSVGEYEVHKG	ZNF479	126	Q96JC4
IHTGEKRYECKQCGK	ZNF124	171	Q15973
KRIHAGEKFYKCEVC	ZNF492	356	Q9P255
IIHAGKKLYKCEECG	ZNF91	566	Q05481
IIHAGEKLYKCEECG	ZNF91	706	Q05481
IIHAGEKLYKCEECG	ZNF91	846	Q05481
IHSGEKRYKCNLCGK	ZNF445	861	P59923
IHIGKKQYICRKCGK	ZNF140	266	P52738
KIIHTGEKFYKCEEC	ZNF98	341	A6NK75
IHLGEKQYKCDICGK	ZNF765	236	Q7L2R6
RLHGGEKSYKCKVCD	ZNF611	446	Q8N823
LRIHTGEKPYKCKEC	ZFP14	191	Q9HCL3
HTAEKLYECKECGKA	ZFP14	306	Q9HCL3
VHTEEKLYKCEECGK	ZNF355P	356	Q9NSJ1
IHGIGKLYKCNDCHK	ZNF860	391	A6NHJ4
KIHTGVKLYKCSECG	ZNF12	401	P17014
IIHLGDKQYKCDVCG	ZNF701	301	Q9NV72
HTGEKLYKCNKCGKE	ZNF766	321	Q5HY98
LLIHTGEKPYKCKEC	ZNF766	346	Q5HY98
KIHLRKKSYLCNECG	ZNF354B	346	Q96LW1
KIHIGKTNYECKECG	ZNF699	271	Q32M78
IHAGEKLYKCETCDK	ZNF600	631	Q6ZNG1
GIYDCAKKILKHEGL	SLC25A24	326	Q6NUK1
HTGEKLYKCKECGKA	ZNF850	191	A8MQ14
IHTGEKRYKCLECGK	ZNF254	371	O75437
DHTKEKLYKCEECGR	ZNF284	336	Q2VY69
GEQIGHKVKKICDCY	ATP6V0A2	231	Q9Y487