Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetyl-CoA carboxylase activity	ACACA ACACB	2.01e-05	2	90	2	GO:0003989
GeneOntologyMolecularFunction	glycogen phosphorylase activity	PYGB PYGL	6.01e-05	3	90	2	GO:0008184
GeneOntologyMolecularFunction	organic acid binding	SLC6A6 STX3 ACACA ACACB PYGL GRIN2A RYR2	1.51e-04	254	90	7	GO:0043177
GeneOntologyMolecularFunction	1,4-alpha-oligoglucan phosphorylase activity	PYGB PYGL	1.99e-04	5	90	2	GO:0004645
GeneOntologyMolecularFunction	CoA carboxylase activity	ACACA ACACB	2.98e-04	6	90	2	GO:0016421
GeneOntologyMolecularFunction	biotin binding	ACACA ACACB	2.98e-04	6	90	2	GO:0009374
GeneOntologyMolecularFunction	ligase activity, forming carbon-carbon bonds	ACACA ACACB	4.16e-04	7	90	2	GO:0016885
GeneOntologyBiologicalProcess	malonyl-CoA biosynthetic process	ACACA ACACB	1.88e-05	2	90	2	GO:2001295
GeneOntologyCellularComponent	protein phosphatase type 2A complex	PPP2R2B PPP2R2D IER5	5.81e-05	18	89	3	GO:0000159
Domain	AcCoA_COase_cen	ACACA ACACB	2.35e-05	2	91	2	IPR013537
Domain	ACC_central	ACACA ACACB	2.35e-05	2	91	2	PF08326
Domain	DVL-1	DVL1P1 DVL1	2.35e-05	2	91	2	IPR008340
Domain	PHOSPHORYLASE	PYGB PYGL	7.02e-05	3	91	2	PS00102
Domain	Phosphorylase	PYGB PYGL	7.02e-05	3	91	2	PF00343
Domain	Glycg_phsphrylas	PYGB PYGL	7.02e-05	3	91	2	IPR011833
Domain	Glyco_trans_35	PYGB PYGL	7.02e-05	3	91	2	IPR000811
Domain	PP2A_PR55	PPP2R2B PPP2R2D	1.40e-04	4	91	2	IPR000009
Domain	PP2A_PR55_CS	PPP2R2B PPP2R2D	1.40e-04	4	91	2	IPR018067
Domain	COA_CT_N	ACACA ACACB	1.40e-04	4	91	2	IPR011762
Domain	COA_CT_C	ACACA ACACB	1.40e-04	4	91	2	IPR011763
Domain	Dishevelled_fam	DVL1P1 DVL1	1.40e-04	4	91	2	IPR008339
Domain	Dishevelled	DVL1P1 DVL1	1.40e-04	4	91	2	PF02377
Domain	Carboxyl_trans	ACACA ACACB	1.40e-04	4	91	2	PF01039
Domain	Dishevelled_protein_dom	DVL1P1 DVL1	1.40e-04	4	91	2	IPR003351
Domain	COA_CT_CTER	ACACA ACACB	1.40e-04	4	91	2	PS50989
Domain	Carboxyl_trans	ACACA ACACB	1.40e-04	4	91	2	IPR000022
Domain	COA_CT_NTER	ACACA ACACB	1.40e-04	4	91	2	PS50980
Domain	PR55_2	PPP2R2B PPP2R2D	1.40e-04	4	91	2	PS01025
Domain	PR55_1	PPP2R2B PPP2R2D	1.40e-04	4	91	2	PS01024
Domain	Biotin_BS	ACACA ACACB	2.33e-04	5	91	2	IPR001882
Domain	Biotin_carb_C	ACACA ACACB	2.33e-04	5	91	2	SM00878
Domain	Biotin_carb_C	ACACA ACACB	2.33e-04	5	91	2	PF02785
Domain	Biotin_carboxylation_dom	ACACA ACACB	2.33e-04	5	91	2	IPR011764
Domain	CPSASE_1	ACACA ACACB	2.33e-04	5	91	2	PS00866
Domain	Biotin_COase_C	ACACA ACACB	2.33e-04	5	91	2	IPR005482
Domain	BIOTIN	ACACA ACACB	2.33e-04	5	91	2	PS00188
Domain	BC	ACACA ACACB	2.33e-04	5	91	2	PS50979
Domain	CPSASE_2	ACACA ACACB	3.48e-04	6	91	2	PS00867
Domain	Rudment_hybrid_motif	ACACA ACACB	3.48e-04	6	91	2	IPR011054
Domain	Znf_C2H2-like	ZNF823 ZNF311 ZNF136 ZNF143 ZNF878 ZNF555 MATR3 ZBTB40 ZNF622 ZNF101 ZBTB14 ZNF563	4.73e-04	796	91	12	IPR015880
Domain	CPSase_L_D2	ACACA ACACB	4.85e-04	7	91	2	PF02786
Domain	DIX	DVL1P1 DVL1	4.85e-04	7	91	2	PF00778
Domain	CbamoylP_synth_lsu-like_ATP-bd	ACACA ACACB	4.85e-04	7	91	2	IPR005479
Domain	BC-like_N	ACACA ACACB	4.85e-04	7	91	2	IPR005481
Domain	Biotin_carb_N	ACACA ACACB	4.85e-04	7	91	2	PF00289
Domain	DIX	DVL1P1 DVL1	4.85e-04	7	91	2	IPR001158
Domain	DIX	DVL1P1 DVL1	4.85e-04	7	91	2	PS50841
Domain	DAX	DVL1P1 DVL1	4.85e-04	7	91	2	SM00021
Domain	ZnF_C2H2	ZNF823 ZNF311 ZNF136 ZNF143 ZNF878 ZNF555 MATR3 ZBTB40 ZNF622 ZNF101 ZBTB14 ZNF563	5.41e-04	808	91	12	SM00355
Domain	Biotin_lipoyl	ACACA ACACB	8.27e-04	9	91	2	PF00364
Domain	Biotin_lipoyl	ACACA ACACB	1.03e-03	10	91	2	IPR000089
Domain	BIOTINYL_LIPOYL	ACACA ACACB	1.03e-03	10	91	2	PS50968
Domain	Single_hybrid_motif	ACACA ACACB	1.50e-03	12	91	2	IPR011053
Domain	-	ZNF823 ZNF311 ZNF136 ZNF143 ZNF878 ZNF555 ZBTB40 ZNF101 ZBTB14 ZNF563	1.71e-03	679	91	10	3.30.160.60
Domain	-	ACACA ACACB	1.77e-03	13	91	2	3.40.50.20
Domain	Znf_C2H2	ZNF823 ZNF311 ZNF136 ZNF143 ZNF878 ZNF555 ZBTB40 ZNF622 ZNF101 ZBTB14 ZNF563	1.82e-03	805	91	11	IPR007087
Domain	KRAB	ZNF823 ZNF311 ZNF136 ZNF878 ZNF555 ZNF101 ZNF563	1.83e-03	358	91	7	PS50805
Domain	KRAB	ZNF823 ZNF311 ZNF136 ZNF878 ZNF555 ZNF101 ZNF563	1.83e-03	358	91	7	PF01352
Domain	zf-C2H2	ZNF823 ZNF311 ZNF136 ZNF143 ZNF878 ZNF555 ZBTB40 ZNF101 ZBTB14 ZNF563	1.99e-03	693	91	10	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF823 ZNF311 ZNF136 ZNF143 ZNF878 ZNF555 ZBTB40 ZNF101 ZBTB14 ZNF563	2.01e-03	694	91	10	IPR013087
Domain	Dynein_heavy_chain_D4_dom	DNAH5 DNAH7	2.06e-03	14	91	2	IPR024317
Domain	Dynein_HC_stalk	DNAH5 DNAH7	2.06e-03	14	91	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH5 DNAH7	2.06e-03	14	91	2	IPR013602
Domain	ATP-grasp	ACACA ACACB	2.06e-03	14	91	2	IPR011761
Domain	DHC_N2	DNAH5 DNAH7	2.06e-03	14	91	2	PF08393
Domain	PreATP-grasp_dom	ACACA ACACB	2.06e-03	14	91	2	IPR016185
Domain	MT	DNAH5 DNAH7	2.06e-03	14	91	2	PF12777
Domain	AAA_8	DNAH5 DNAH7	2.06e-03	14	91	2	PF12780
Domain	ATP_GRASP	ACACA ACACB	2.06e-03	14	91	2	PS50975
Domain	KRAB	ZNF823 ZNF311 ZNF136 ZNF878 ZNF555 ZNF101 ZNF563	2.17e-03	369	91	7	SM00349
Domain	KRAB	ZNF823 ZNF311 ZNF136 ZNF878 ZNF555 ZNF101 ZNF563	2.20e-03	370	91	7	IPR001909
Domain	DHC_fam	DNAH5 DNAH7	2.37e-03	15	91	2	IPR026983
Domain	Clathrin/coatomer_adapt-like_N	COPB1 AP1G1	2.37e-03	15	91	2	IPR002553
Domain	Adaptin_N	COPB1 AP1G1	2.37e-03	15	91	2	PF01602
Domain	Dynein_heavy_dom	DNAH5 DNAH7	2.37e-03	15	91	2	IPR004273
Domain	Dynein_heavy	DNAH5 DNAH7	2.37e-03	15	91	2	PF03028
Domain	-	ACACA ACACB	2.37e-03	15	91	2	3.30.1490.20
Domain	-	ATP2C2 ATP2A3	2.70e-03	16	91	2	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP2C2 ATP2A3	2.70e-03	16	91	2	IPR023298
Domain	ATPase_P-typ_cation-transptr_C	ATP2C2 ATP2A3	3.04e-03	17	91	2	IPR006068
Domain	Cation_ATPase_C	ATP2C2 ATP2A3	3.04e-03	17	91	2	PF00689
Domain	ATP_grasp_subdomain_1	ACACA ACACB	3.41e-03	18	91	2	IPR013815
Domain	Cation_ATPase_N	ATP2C2 ATP2A3	3.41e-03	18	91	2	PF00690
Domain	Cation_ATPase_N	ATP2C2 ATP2A3	3.41e-03	18	91	2	SM00831
Domain	-	ACACA ACACB	3.41e-03	18	91	2	3.30.470.20
Domain	ATPase_P-typ_cation-transptr_N	ATP2C2 ATP2A3	3.80e-03	19	91	2	IPR004014
Domain	ZINC_FINGER_C2H2_2	ZNF823 ZNF311 ZNF136 ZNF143 ZNF878 ZNF555 ZBTB40 ZNF101 ZBTB14 ZNF563	4.42e-03	775	91	10	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF823 ZNF311 ZNF136 ZNF143 ZNF878 ZNF555 ZBTB40 ZNF101 ZBTB14 ZNF563	4.51e-03	777	91	10	PS00028
Domain	-	ACACA ACACB	4.64e-03	21	91	2	3.90.226.10
Domain	ClpP/crotonase-like_dom	ACACA ACACB	4.64e-03	21	91	2	IPR029045
Pubmed	USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.	USP53 ACACA ACACB COPB1 PYGB TUFM	1.51e-07	90	92	6	35654790
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	FBLL1 ACACA BAZ2A ANLN RANBP3 MATR3 DVL1 SMARCE1 TAF4 TUFM PCM1	2.33e-07	549	92	11	38280479
Pubmed	An integrated workflow for charting the human interaction proteome: insights into the PP2A system.	ZNF136 PPP2R2B PPP2R2D IER5 CEP43 TUFM	3.79e-07	105	92	6	19156129
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF311 ZNF136 ZNF878 ZNF555 ZNF101 TFRC ZNF563	5.55e-07	181	92	7	37372979
Pubmed	HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.	PPP2R2B PPP2R2D IER5	6.22e-07	7	92	3	25816751
Pubmed	SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation.	AP1G1 MATR3 PYGB PYGL TFRC	7.82e-07	64	92	5	26511642
Pubmed	Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4.	COPB1 AP1G1 TFRC	9.94e-07	8	92	3	10444069
Pubmed	Human transcription factor protein interaction networks.	ZNF143 ESS2 ACACB COPB1 MATR3 SMARCA1 ZBTB40 RACGAP1 SMARCE1 TAF4 HAL GMEB2 PCM1 ZBTB14 CNOT8 TFRC	1.00e-06	1429	92	16	35140242
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ZNF823 PPP2R2B RNF123 ZNF143 ACACB POLE LAMC1 SMARCE1 DNAH7 RYR2 CNOT8	1.02e-06	638	92	11	31182584
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	FBLL1 ACACA ACACB COPB1 RANBP3 MATR3 SMARCA1 PYGL SMARCE1 PCM1 TFRC	1.52e-06	665	92	11	30457570
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	NAA35 URB1 ACACA COPB1 AP1G1 BAZ2A ANLN POLE MATR3 SMARCA1 RACGAP1 PYGB PYGL TUFM TFRC	2.58e-06	1353	92	15	29467282
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	ACACA COPB1 AP1G1 ANLN POLE SMARCA1 ZNF622 SMARCE1 DNAH5 ATP2A3 TUFM	2.63e-06	704	92	11	29955894
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	PELP1 BAZ2A MATR3 SMARCA1 SMARCE1 TAF4	3.06e-06	150	92	6	28242625
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	ZNF311 COPB1 AP1G1 MATR3 SMARCA1 PYGB PYGL TUFM TFRC	3.21e-06	451	92	9	36168627
Pubmed	Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.	PPP2R2B RNF123 COPB1 PPP2R2D PYGB	3.61e-06	87	92	5	17148452
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	FBXO38 ZNF136 ESS2 BAZ2A ANLN SMARCA1 ZBTB40 RACGAP1 SMARCE1 TAF4	4.94e-06	608	92	10	36089195
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	MIA3 ANLN RANBP3 KIAA1217 MATR3 RB1CC1 ATPAF1 TUFM	5.33e-06	360	92	8	33111431
Pubmed	De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.	ACACA ACACB	6.92e-06	2	92	2	25282359
Pubmed	Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.	ACACA ACACB	6.92e-06	2	92	2	27693630
Pubmed	Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue.	ACACA ACACB	6.92e-06	2	92	2	32215608
Pubmed	Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor.	ACACA ACACB	6.92e-06	2	92	2	29772612
Pubmed	Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin.	ACACA ACACB	6.92e-06	2	92	2	29976587
Pubmed	Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.	ACACA ACACB	6.92e-06	2	92	2	24944901
Pubmed	Structure and regulation of acetyl-CoA carboxylase genes of metazoa.	ACACA ACACB	6.92e-06	2	92	2	15749055
Pubmed	Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription.	ACACA ACACB	6.92e-06	2	92	2	20139635
Pubmed	Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.	ACACA ACACB	6.92e-06	2	92	2	28081256
Pubmed	Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.	ACACA ACACB	6.92e-06	2	92	2	26976583
Pubmed	AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis.	ACACA ACACB	6.92e-06	2	92	2	29433631
Pubmed	Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin.	ACACA ACACB	6.92e-06	2	92	2	36076520
Pubmed	AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation.	ACACA ACACB	6.92e-06	2	92	2	25001074
Pubmed	Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.	DVL1P1 DVL1	6.92e-06	2	92	2	8644734
Pubmed	The subcellular localization of acetyl-CoA carboxylase 2.	ACACA ACACB	6.92e-06	2	92	2	10677481
Pubmed	Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.	ACACA ACACB	6.92e-06	2	92	2	28290443
Pubmed	Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.	ACACA ACACB	6.92e-06	2	92	2	30244972
Pubmed	Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA carboxylases 1 and 2.	ACACA ACACB	6.92e-06	2	92	2	24338821
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	URB1 ACACA PELP1 COPB1 BAZ2A POLE PYGB PYGL TUFM PCM1	9.20e-06	653	92	10	22586326
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	FBXO38 URB1 COPB1 PPP2R2D ANLN MATR3 IFFO2 RACGAP1 SMARCE1 CEP43 PCM1 CNOT8 TFRC	1.10e-05	1155	92	13	20360068
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	MIA3 STX3 ESS2 ACACB AP1G1 RACGAP1 LAMC1 STAM CEP43 ATPAF1 PCM1 TFRC	1.41e-05	1007	92	12	34597346
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	ACACA PELP1 COPB1 AP1G1 ANLN RANBP3 NAE1 PYGB LAMC1 PYGL SMARCE1 HAL TUFM TFRC	1.41e-05	1367	92	14	32687490
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	URB1 FBLL1 PELP1 MATR3 LAMC1 TFRC	1.68e-05	202	92	6	24639526
Pubmed	Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches.	ACACA ACACB AP1G1 DVL1 TAF4 VPS37B	1.68e-05	202	92	6	29540532
Pubmed	Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development.	PPP2R2B PPP2R2D LAMC1	1.68e-05	19	92	3	32582689
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	USP53 ACACA ANLN RANBP3 KIAA1217 MATR3 RACGAP1 LAMC1 DNAH7 ABTB2 PCM1	1.74e-05	861	92	11	36931259
Pubmed	AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue.	ACACA ACACB	2.07e-05	3	92	2	34668531
Pubmed	AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation.	ACACA ACACB	2.07e-05	3	92	2	30018077
Pubmed	Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels.	ACACA ACACB	2.07e-05	3	92	2	19846279
Pubmed	Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels.	ACACA ACACB	2.07e-05	3	92	2	18031993
Pubmed	Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.	ACACA ACACB	2.07e-05	3	92	2	28877461
Pubmed	Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis.	ACACA ACACB	2.07e-05	3	92	2	20457939
Pubmed	Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism.	ACACA ACACB	2.07e-05	3	92	2	36417534
Pubmed	MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis.	ANLN RACGAP1	2.07e-05	3	92	2	16129829
Pubmed	Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas.	ACACA ACACB	2.07e-05	3	92	2	17521700
Pubmed	Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate.	ACACA ACACB	2.07e-05	3	92	2	18455495
Pubmed	Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis.	ACACA ACACB	2.07e-05	3	92	2	31990961
Pubmed	The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels.	ACACA ACACB	2.07e-05	3	92	2	27381369
Pubmed	Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice.	ACACA ACACB	2.07e-05	3	92	2	17210641
Pubmed	Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.	ACACA ACACB	2.07e-05	3	92	2	28768177
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	ACACA ACACB COPB1 BAZ2A RANBP3 KIAA1217 MATR3 ZNF622 SMARCE1 STAM PCM1	3.66e-05	934	92	11	33916271
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	FBXO38 ACACB PELP1 MATR3 DNAH5 TUFM	3.83e-05	234	92	6	36243803
Pubmed	cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.	DVL1P1 DVL1	4.14e-05	4	92	2	8817329
Pubmed	Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease.	HAP1 PCM1	4.14e-05	4	92	2	21985783
Pubmed	Human dishevelled genes constitute a DHR-containing multigene family.	DVL1P1 DVL1	4.14e-05	4	92	2	9192851
Pubmed	Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability.	ACACA ACACB	4.14e-05	4	92	2	38447582
Pubmed	Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4.	DVL1P1 DVL1	4.14e-05	4	92	2	20639201
Pubmed	An integrated somatic cell hybrid, YAC, and BAC map of the Rmc1 region of mouse chromosome 1.	LAMC1 IER5	4.14e-05	4	92	2	10373331
Pubmed	Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.	ACACA ACACB	4.14e-05	4	92	2	24185692
Pubmed	Crystal structure of Spot 14, a modulator of fatty acid synthesis.	ACACA ACACB	4.14e-05	4	92	2	20952656
Pubmed	Interaction network of human early embryonic transcription factors.	ACACB SMARCA1 SMARCE1 TAF4 TUFM ZBTB14 TFRC	4.22e-05	351	92	7	38297188
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	ZNF143 ACACA RANBP3 IFFO2 SMARCE1 RB1CC1 DYSF	5.21e-05	363	92	7	14691545
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	NAA35 MIA3 ACACA COPB1 PPP2R2D AP1G1 MATR3 PYGB TUFM TFRC	5.56e-05	807	92	10	30575818
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	COPB1 ANLN RANBP3 DVL1 PCM1 TFRC	6.30e-05	256	92	6	33397691
Pubmed	Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.	HAP1 PCM1	6.89e-05	5	92	2	9361024
Pubmed	Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.	ACACA ACACB	6.89e-05	5	92	2	37163372
Pubmed	Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?	HJV TFRC	6.89e-05	5	92	2	25860887
Pubmed	Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta.	HJV SLC6A6	6.89e-05	5	92	2	8010975
Pubmed	Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss.	ACACA ACACB	6.89e-05	5	92	2	32694673
Pubmed	TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.	ACACA ACACB	6.89e-05	5	92	2	16794074
Pubmed	Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling.	DVL1P1 AP1G1 DVL1 PLD1 TUFM	7.10e-05	161	92	5	36398662
Pubmed	Secretory protein trafficking and organelle dynamics in living cells.	COPB1 AP1G1 STAM VPS37B	7.88e-05	85	92	4	11031247
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	USP53 MIA3 ACACA ACACB IFFO1 KIAA1217 IFFO2 LRRCC1 DNAH7 PCM1	8.79e-05	853	92	10	28718761
Pubmed	The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.	ACACA COPB1 AP1G1	9.23e-05	33	92	3	26296893
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	URB1 ACACA PELP1 COPB1 AP1G1 POLE MATR3 SMARCA1 RACGAP1 SMARCE1 DNAH5 TUFM TFRC	9.55e-05	1425	92	13	30948266
Pubmed	LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.	ACACA ACACB RYR2	1.01e-04	34	92	3	26378152
Pubmed	Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system.	COPB1 AP1G1	1.03e-04	6	92	2	11409905
Pubmed	The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding.	HJV TFRC	1.03e-04	6	92	2	9465039
Pubmed	WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci.	BAZ2A SMARCA1	1.03e-04	6	92	2	11980720
Pubmed	mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells.	PPP2R2B PLD1	1.03e-04	6	92	2	16109716
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	FBLL1 ACACA BAZ2A MATR3 SMARCA1 SMARCE1 TUFM	1.13e-04	411	92	7	35182466
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	URB1 MIA3 COPB1 ABCB11 ATP2A3 PCM1	1.14e-04	285	92	6	32838362
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	ESS2 ACACA ACACB MATR3 RAVER2	1.20e-04	180	92	5	35198878
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	PELP1 COPB1 AP1G1 RANBP3 MATR3 RACGAP1 PYGB TUFM	1.22e-04	560	92	8	35241646
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	COL6A1 ACACA ACACB DVL1 LAMC1 RB1CC1 PCM1	1.25e-04	418	92	7	34709266
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	SLFN12L URB1 MIA3 AP1G1 ANLN MATR3 ZBTB40 ZNF101 PLD1 F13A1 CNOT8	1.38e-04	1084	92	11	11544199
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	PPP2R2B ACACB PPP2R2D PYGL IER5 CEP43 TUFM TFRC	1.43e-04	573	92	8	28330616
Pubmed	Selective proteasomal degradation of the B'β subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15.	PPP2R2B PPP2R2D	1.44e-04	7	92	2	23135275
Pubmed	Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78).	PYGB TUFM	1.44e-04	7	92	2	32606430
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	ESS2 COPB1 RAVER2 RACGAP1 ATP2A3 TFRC	1.45e-04	298	92	6	30737378
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	NAA35 URB1 MIA3 BAZ2A RANBP3 POLE NAE1 ZNF622 LAMC1 RB1CC1 ATPAF1 PCM1 TFRC	1.46e-04	1487	92	13	33957083
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	USP53 ESS2 RASAL3 ACACB TRO RANBP3 VPS37B	1.49e-04	430	92	7	35044719
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	NAA35 MIA3 ACACA PELP1 ANLN RACGAP1 LAMC1 STAM RB1CC1 ATPAF1 PCM1 TFRC	1.59e-04	1297	92	12	33545068
Interaction	TRIM28 interactions	ZNF823 ZNF311 ZNF136 PPP2R2B ZNF878 ZNF555 ACACA COPB1 AP1G1 ANLN POLE MATR3 SMARCA1 ZNF622 SMARCE1 ZNF101 TAF4 DNAH5 ATP2A3 TUFM TFRC ZNF563	4.59e-07	1474	91	22	int:TRIM28
Interaction	NR3C1 interactions	ZNF823 PPP2R2B RNF123 ZNF143 ACACB PELP1 ANLN POLE PSMC3IP LAMC1 SMARCE1 DNAH7 CEP43 TUFM RYR2 CNOT8 TFRC	1.46e-06	974	91	17	int:NR3C1
Interaction	NTF3 interactions	COL6A1 PYGB LAMC1 PYGL	6.30e-06	27	91	4	int:NTF3
Interaction	IER5 interactions	PPP2R2B PPP2R2D IER5	2.47e-05	13	91	3	int:IER5
Interaction	SNRNP40 interactions	URB1 ESS2 ACACA ACACB PELP1 BAZ2A ANLN RAVER2 DVL1 SMARCA1 TAF4 GMEB2	2.89e-05	637	91	12	int:SNRNP40
Interaction	USP53 interactions	USP53 ACACA ACACB COPB1 PYGB TUFM	3.82e-05	138	91	6	int:USP53
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ZNF823 ZNF136 ZNF878 ZNF555 RASAL3 RANBP3 ZNF101 ZNF563	2.06e-04	797	92	8	chr19p13
GeneFamily	Intermediate filament family orphans	IFFO1 IFFO2	1.16e-05	2	62	2	614
GeneFamily	Glycogen phosphorylases	PYGB PYGL	3.46e-05	3	62	2	437
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF823 ZNF311 ZNF136 ZNF143 ZNF878 ZNF555 ZBTB40 ZNF101 ZBTB14 ZNF563	1.52e-04	718	62	10	28
GeneFamily	ATPases Ca2+ transporting	ATP2C2 ATP2A3	4.10e-04	9	62	2	1209
GeneFamily	WD repeat domain containing\|Protein phosphatase 2 regulatory subunits	PPP2R2B PPP2R2D	1.18e-03	15	62	2	696
GeneFamily	Dyneins, axonemal	DNAH5 DNAH7	1.52e-03	17	62	2	536
Coexpression	GSE45739_NRAS_KO_VS_WT_ACD3_ACD28_STIM_CD4_TCELL_DN	ZBTB40 RACGAP1 LAMC1 PLD1 STAM RB1CC1 ATPAF1	5.98e-06	198	91	7	M9882
Drug	H-AKH	HJV PYGB PYGL RB1CC1	7.00e-07	18	91	4	CID000123821
Drug	xenon	AP1G1 BAZ2A ATP2C2 GRIN2A ATP2A3 CNOT8	1.44e-06	88	91	6	CID000023991
Drug	9 Da	ACACA PYGB PYGL	9.96e-06	11	91	3	CID005287565
Drug	Captopril [62571-86-2]; Down 200; 17.2uM; PC3; HG-U133A	COL6A1 NAA35 RNF123 ACACA BAZ2A PYGB ABTB2	1.53e-05	199	91	7	1907_DN
Drug	2-Chloropyrazine [14508-49-7]; Up 200; 35uM; MCF7; HT_HG-U133A	COL6A1 RNF123 BAZ2A LAMC1 ATP2A3 ZBTB14 CNOT8	1.58e-05	200	91	7	6227_UP
Drug	5-(2-chloroethyl)uracil	PYGB PYGL	1.58e-05	2	91	2	CID010442204
Drug	6878P	PYGB PYGL	1.58e-05	2	91	2	CID002725013
Drug	AC1LBRFU	PYGB PYGL	1.58e-05	2	91	2	CID000562981
Drug	1,2-dimethoxyethane	ESS2 ACACA PYGB PYGL	2.38e-05	42	91	4	CID000008071
Drug	europium	ACACA BAZ2A DNAH5 RYR2 CNOT8	2.60e-05	87	91	5	CID000023981
Drug	Gvapspat amide	PYGB PYGL RYR2	2.71e-05	15	91	3	CID000125015
Drug	3,5-dimethylphenyl isocyanate	PYGB PYGL	4.73e-05	3	91	2	CID000521488
Drug	5'-deoxy-5'-fluoro-5'-(methylthio)adenosine	PYGB PYGL	4.73e-05	3	91	2	CID000147839
Drug	NSC758405	PYGB PYGL	4.73e-05	3	91	2	CID000003201
Drug	3,5-dinitrophenyl phosphate	PYGB PYGL	4.73e-05	3	91	2	CID000151920
Drug	pyridoxal phosphoglucose	PYGB PYGL	4.73e-05	3	91	2	CID000196007
Drug	Aspaminol	PYGB PYGL	4.73e-05	3	91	2	CID003084278
Drug	5-ethyl-4-hydroxy-2-methyl-3(2H)-furanone	PYGB PYGL	4.73e-05	3	91	2	CID000093111
Drug	adenosine-5'-chloromethylphosphonate	PYGB PYGL	4.73e-05	3	91	2	CID000191554
Drug	hydan	PYGB PYGL	4.73e-05	3	91	2	CID000008360
Drug	EHMF	PYGB PYGL	4.73e-05	3	91	2	CID000033931
Drug	AC1L29EX	PYGB PYGL	4.73e-05	3	91	2	CID000043221
Drug	pyridoxal 5'-methylenephosphonate	PYGB PYGL	4.73e-05	3	91	2	CID003082249
Drug	Plp 5'-mpa	PYGB PYGL	4.73e-05	3	91	2	CID003082151
Drug	glucose-1,2-cyclic phosphate	PYGB PYGL	4.73e-05	3	91	2	CID000191723
Drug	N,N'-diethylethylenediamine	ACACA TRO	4.73e-05	3	91	2	CID000067105
Drug	3'-FFdUrd	PYGB PYGL	4.73e-05	3	91	2	CID000072260
Drug	2',3',4',5,5'-pentachloro-2-biphenylol	PYGB PYGL	4.73e-05	3	91	2	CID000119518
Drug	AC1L8XK3	PYGB PYGL	4.73e-05	3	91	2	CID000409735
Drug	N-acetyl-N'-beta-D-glucopyranosyl urea	PYGB PYGL	4.73e-05	3	91	2	CID000446801
Drug	riboflavin tetraacetate	PYGB PYGL	4.73e-05	3	91	2	CID000094186
Drug	2,5-dimethyl-3-furanone	PYGB PYGL	4.73e-05	3	91	2	CID000085730
Drug	3,5-dinitrophenol	PYGB PYGL	4.73e-05	3	91	2	CID000011459
Drug	sucrose-6-phosphate	ANLN PYGB PYGL	4.83e-05	18	91	3	CID000644101
Drug	Digoxin [20830-75-5]; Up 200; 5.2uM; MCF7; HT_HG-U133A	SLC6A6 COL6A1 ZNF143 STX3 BAZ2A ZBTB40	5.48e-05	166	91	6	3283_UP
Drug	dhpta	ZNF143 HAL DNAH5 MUC4 CNOT8	6.15e-05	104	91	5	CID000018465
Drug	I0329	HJV PYGB PYGL	7.80e-05	21	91	3	CID000439668
Drug	2-deoxy-D-glucose 6-phosphate	HJV PYGB PYGL	7.80e-05	21	91	3	CID000440992
Drug	galocitabine	PYGB PYGL	9.43e-05	4	91	2	CID000065950
Drug	5-deoxyribose-1-phosphate	PYGB PYGL	9.43e-05	4	91	2	CID000135786
Drug	ingliforib	PYGB PYGL	9.43e-05	4	91	2	CID006451325
Drug	uric acid riboside	PYGB PYGL	9.43e-05	4	91	2	CID000164933
Drug	pseudo-dl-glucose	PYGB PYGL	9.43e-05	4	91	2	CID000125259
Drug	pyridoxal diphosphate	PYGB PYGL	9.43e-05	4	91	2	CID000125696
Drug	2,5-anhydro-D-mannitol 1-phosphate	PYGB PYGL	9.43e-05	4	91	2	CID000189134
Drug	AC1LAMW2	PYGB PYGL	9.43e-05	4	91	2	CID000491364
Drug	FdUrd-C8	PYGB PYGL	9.43e-05	4	91	2	CID000094262
Drug	N,N-diethylethylenediamine	ACACA TRO	9.43e-05	4	91	2	CID000060993
Drug	Mem-CC	PYGB PYGL	9.43e-05	4	91	2	CID003081269
Drug	2H-5a	PYGB PYGL	9.43e-05	4	91	2	CID000440102
Drug	BCIp4A	PYGB PYGL	9.43e-05	4	91	2	CID000192417
Drug	3'-chloromethotrexate	PYGB PYGL	9.43e-05	4	91	2	CID000097703
Drug	magnesium oxide	ZNF143 BAZ2A CNOT8	1.03e-04	23	91	3	CID000014792
Drug	Digoxigenin [1672-46-4]; Down 200; 10.2uM; PC3; HT_HG-U133A	MIA3 ESS2 ACACB RANBP3 RPUSD2 CEP43	1.16e-04	190	91	6	4680_DN
Drug	BrVarafUTP	POLE PYGB PYGL	1.18e-04	24	91	3	CID005273539
Drug	octadec-9-en-1-amine	ACACA PLD1 CNOT8	1.18e-04	24	91	3	CID000008219
Drug	15(S)-15-methyl Prostaglandin E2; Up 200; 10uM; PC3; HT_HG-U133A	FBXO38 COL6A1 ATP2C2 CEP43 ZBTB14 CNOT8	1.22e-04	192	91	6	7526_UP
Drug	alpha-estradiol; Down 200; 0.01uM; MCF7; HT_HG-U133A_EA	RANBP3 RPUSD2 PYGB GMEB2 ATP2A3 CEP43	1.26e-04	193	91	6	1048_DN
Drug	Chlortetracycline hydrochloride [64-72-2]; Down 200; 7.8uM; HL60; HG-U133A	ACACA BAZ2A RANBP3 ZBTB40 GMEB2 ATP2A3	1.29e-04	194	91	6	2042_DN
Drug	Triamcinolone [124-94-7]; Down 200; 10.2uM; MCF7; HT_HG-U133A	SLC6A6 COL6A1 PPP2R2B URB1 PCM1 RYR2	1.33e-04	195	91	6	2241_DN
Drug	Thomsen-Friedenreich antigen	PYGB PYGL RB1CC1 MUC4	1.34e-04	65	91	4	CID000065121
Drug	rosiglitazone; Up 200; 10uM; MCF7; HT_HG-U133A	SLC6A6 COL6A1 HAP1 PLD1 RB1CC1 ATP2A3	1.37e-04	196	91	6	5230_UP
Drug	Pentamidine isethionate [140-64-7]; Down 200; 6.8uM; HL60; HT_HG-U133A	STX3 BAZ2A ZBTB40 PYGB DYSF PCM1	1.37e-04	196	91	6	2473_DN
Drug	Antipyrine, 4-hydroxy [1672-63-5]; Up 200; 19.6uM; MCF7; HT_HG-U133A	COL6A1 ZNF136 HAP1 IFFO1 RANBP3 PCDH1	1.37e-04	196	91	6	1497_UP
Drug	Naloxone hydrochloride [357-08-4]; Up 200; 11uM; MCF7; HT_HG-U133A	SLC6A6 FBXO38 PPP2R2B ACACB DYSF ATP2A3	1.41e-04	197	91	6	1506_UP
Drug	deferoxamine mesylate salt; Down 200; 100uM; PC3; HG-U133A	NAA35 RPUSD2 IER5 STAM CEP43 PCM1	1.41e-04	197	91	6	460_DN
Drug	Atropine sulfate monohydrate [5908-99-6]; Down 200; 5.8uM; PC3; HT_HG-U133A	ESS2 ACACB BAZ2A RANBP3 RYR2 CNOT8	1.41e-04	197	91	6	5865_DN
Drug	5707885; Down 200; 50uM; MCF7; HT_HG-U133A	SLC6A6 BAZ2A TRO RAVER2 PCDH1 F13A1	1.41e-04	197	91	6	6385_DN
Drug	Sulfachloropyridazine [80-32-0]; Down 200; 14uM; MCF7; HT_HG-U133A	SLC6A6 MIA3 HAP1 RANBP3 PCM1 RYR2	1.45e-04	198	91	6	3944_DN
Drug	wortmannin from Penicillium funiculosum; Down 200; 0.01uM; HL60; HT_HG-U133A	URB1 BAZ2A POLE RPUSD2 LAMC1 STAM	1.45e-04	198	91	6	1184_DN
Drug	Sulpiride [15676-16-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A	SLC6A6 ACACB BAZ2A PCDH1 F13A1 CNOT8	1.49e-04	199	91	6	4389_UP
Drug	glycine ethyl ester	PYGB PYGL F13A1	1.50e-04	26	91	3	CID000012175
Drug	Cephalosporanic acid, 7-amino [957-68-6]; Up 200; 14.6uM; PC3; HT_HG-U133A	BAZ2A HAP1 RAVER2 ATP2C2 PLD1 F13A1	1.53e-04	200	91	6	4242_UP
Drug	heptulose-2-P	PYGB PYGL	1.57e-04	5	91	2	CID000124823
Drug	6-FPLP	PYGB PYGL	1.57e-04	5	91	2	CID000146246
Drug	gluconohydroximo-1,5-lactone	PYGB PYGL	1.57e-04	5	91	2	CID009576855
Drug	DHPBU	PYGB PYGL	1.57e-04	5	91	2	CID000125914
Drug	5'-isobutylthioinosine	PYGB PYGL	1.57e-04	5	91	2	CID003080910
Drug	indirubin-5-sulphonate	PYGB PYGL	1.57e-04	5	91	2	CID005288641
Drug	VaraU	PYGB PYGL	1.57e-04	5	91	2	CID000126501
Drug	AC1LCUXJ	PYGB PYGL	1.57e-04	5	91	2	CID000656425
Drug	6-amino-5-bromouracil	PYGB PYGL	1.57e-04	5	91	2	CID000080578
Drug	etafenone	PYGB PYGL	1.57e-04	5	91	2	CID000003275
Drug	ddEtUrd	PYGB PYGL	1.57e-04	5	91	2	CID000451452
Drug	5-trifluoromethyl-2'-deoxycytidine	PYGB PYGL	1.57e-04	5	91	2	CID000125618
Drug	BrdAdo	PYGB PYGL	1.57e-04	5	91	2	CID000055914
Drug	m-anisidine	PYGB PYGL	1.57e-04	5	91	2	CID000010824
Drug	2-hydroxypropylphosphonate	PYGB PYGL	1.57e-04	5	91	2	CID000441028
Drug	6-FDPL	PYGB PYGL	1.57e-04	5	91	2	CID000129578
Drug	MBBA	ACACA STAM	1.57e-04	5	91	2	CID000033363
Drug	3'-O-methylpyridoxal 5'-phosphate	PYGB PYGL	1.57e-04	5	91	2	CID003082179
Drug	GlcMan	PYGB PYGL	1.57e-04	5	91	2	CID000152120
Drug	U66985	PYGB PYGL	1.57e-04	5	91	2	CID000127224
Drug	AC1O3M08	PYGB PYGL	1.57e-04	5	91	2	CID006331955
Drug	2-chloropropionate	GRIN2A RB1CC1 DNAH5	1.69e-04	27	91	3	CID000011734
Drug	cantharidic acid	PPP2R2D PYGB PYGL	2.09e-04	29	91	3	CID000002544
Drug	AC1L3NLD	ACACA PYGB PYGL	2.09e-04	29	91	3	CID000092184
Drug	MRK 003	PPP2R2B ATP2C2 CPLX1 IFFO2 ABCB11 PYGL IER5 HAL DYSF ABTB2 F13A1	2.22e-04	760	91	11	ctd:C523799
Drug	norstatine	PYGB PYGL	2.35e-04	6	91	2	CID000173844
Drug	CV-araU	PYGB PYGL	2.35e-04	6	91	2	CID006441877
Disease	DiGeorge syndrome (is_implicated_in)	DVL1P1 DVL1	9.56e-05	5	92	2	DOID:11198 (is_implicated_in)
Disease	muscular disease (implicated_via_orthology)	ACACA ACACB	9.56e-05	5	92	2	DOID:0080000 (implicated_via_orthology)
Disease	heart disease (implicated_via_orthology)	ATP2A3 RYR2 CNOT8	2.29e-04	38	92	3	DOID:114 (implicated_via_orthology)
Disease	rectum cancer	SCOC LAMC1 PYGL	3.08e-04	42	92	3	EFO_1000657
Disease	quality of life during menstruation measurement, dysmenorrheic pain measurement	GRIN2A RB1CC1	5.19e-04	11	92	2	EFO_0007889, EFO_0009366
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	PPP2R2B PPP2R2D	6.22e-04	12	92	2	DOID:1441 (implicated_via_orthology)
Disease	eosinophil count	SLFN12L RASAL3 PELP1 RAVER2 ZBTB40 SMARCE1 IER5 PLD1 GMEB2 DYSF ATP2A3 DNAH7 CEP43	7.04e-04	1488	92	13	EFO_0004842
Disease	Coffin-Siris syndrome	SMARCA1 SMARCE1	7.33e-04	13	92	2	C0265338
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	ACACA ACACB TFRC	1.11e-03	65	92	3	DOID:0080208 (biomarker_via_orthology)
Disease	Cannabis use, age at onset	ATP2C2 RYR2	1.59e-03	19	92	2	EFO_0004847, EFO_0007585
Disease	beverage consumption measurement	ZNF143 PCDH1 RYR2	2.25e-03	83	92	3	EFO_0010088
Disease	Myocardial Ischemia	SLC6A6 PYGB RYR2 TFRC	2.27e-03	176	92	4	C0151744
Disease	Huntington's disease (is_implicated_in)	HAP1 GRIN2A	2.33e-03	23	92	2	DOID:12858 (is_implicated_in)
Disease	unipolar depression, neuroticism measurement	ANO4 KIAA1217	2.54e-03	24	92	2	EFO_0003761, EFO_0007660

Protein segments in the cluster

Peptide	Gene	Start	Entry
ANMEELTEVITAAEF	PPP2R2B	216	Q00005
DEAAEKEMTSVVAEN	BAZ2A	216	Q9UIF9
EDATMEDIVQAAKEA	ABCB11	521	O95342
LEAMDELEVAFNNTN	ACACA	1451	Q13085
ANMEELTEVITAAEF	PPP2R2D	226	Q66LE6
DVDFSEILNAIQEMA	ANO4	41	Q32M45
VAKSAAEMVLSDDNF	ATP2A3	726	Q93084
EAANMILVDDDFSAI	ATP2C2	701	O75185
ILVDDDFSAIMNAVE	ATP2C2	706	O75185
DLTEDNMETENAAAA	GMEB2	46	Q9UKD1
KLINESVDEADMENA	RANBP3	271	Q9H6Z4
QCFLDQVAMVDVDAA	RASAL3	676	Q86YV0
TAEQAEEVQQAADGM	RAVER2	281	Q9HCJ3
AEDVAMAFSAEQDLQ	HJV	301	Q6ZVN8
EAMDELEVAFNNTSV	ACACB	1571	O00763
DDSSEAMNDILAQVA	AP1G1	261	O43747
NVSAMIEEVFEATDI	OARD1	131	Q9Y530
DFMSAVNEFVIEENL	RB1CC1	731	Q8TDY2
SEEENASMAEVNASV	MUC4	5181	Q99102
EAFIEMATTEDAQAA	MATR3	436	P43243
DQFDMVSDADLQVLD	PSMC3IP	76	Q9P2W1
NEFDSDVDVGDLQMV	PNLIP	401	P16233
EKSQEEMDQALAESS	ANLN	581	Q9NQW6
EEREAEAQAAMEANS	CPLX1	76	O14810
MVDVIFADVAQPDQS	FBLL1	241	A6NHQ2
EQAIAVMDDSVVAET	PCM1	311	Q15154
QLQDLVAMVQDDDAA	PCM1	671	Q15154
MANISEDVAEETAVA	PCDH1	401	Q08174
MEFLSDNNEAAAADV	COPB1	406	P53618
RSNVDMDFEVENAVL	F13A1	516	P00488
QAMEQEGATAAETEE	NLRP5	211	P59047
DNCLVMEFDDQATVE	POLE	1701	Q07864
NKADAVQDSEMVELV	TUFM	181	P49411
ALQEKEQDDTAAMLA	PELP1	1096	Q8IZL8
AMAAAEAQGEQEDSL	IFFO1	441	Q0D2I5
FAADALNEMEDIVQE	FBXO38	536	Q6PIJ6
TSEDNASFQEIMEVA	ESS2	156	Q96DF8
NNEFVEVVIEGDAMS	HAL	76	P42357
MAATAAAVVAEEDTE	CEP43	1	O95684
AMDFINDATDVNDAL	COL6A1	906	P12109
TAEMDSTFLNVAEAQ	ATPAF1	256	Q5TC12
ECVEQFSEASQQMAE	HAP1	351	P54257
ADETIANEQAMASKA	DNAH7	2646	Q8WXX0
MVDTLQEAAQEADAI	IFFO2	236	Q5TF58
FAEVTDLDNEVNNML	LAMC1	1451	P11047
NEDVDSAQEKMSILA	CNOT8	271	Q9UFF9
DVNFENMSNDDAVRV	DVL1	306	O14640
DVNFENMSNDDAVRV	DVL1P1	306	P54792
DVAAASVMDNNELAL	RYR2	2241	Q92736
ATMLQDVDDAIQFEV	DYSF	601	O75923
AELDVVQAEYEQAMT	DNAH5	3456	Q8TE73
DDAEEMETGNVANLI	IER5	256	Q5VY09
ELAAAAQKMEEVAEA	RPUSD2	456	Q8IZ73
DDDINDVASMAGVNL	TAF4	831	O00268
AMQDHVFVDTSAEEQ	TRIM42	271	Q8IWZ5
MAQEQGVDIADVAES	SLC6A6	351	P31641
MEQDTAAVAATVAAA	SMARCA1	1	P28370
DMEKIAAEIAQAEEQ	SMARCE1	281	Q969G3
MNENNIFEEAAVLDD	MIA3	1006	Q5JRA6
ANAMEEANEEIFITD	PLD1	366	Q13393
NMANATVVKADAEVD	SLC26A5	586	P58743
NDSEDQDVAMKSFAA	NEXMIF	26	Q5QGS0
QDVAMKSFAALEAAA	NEXMIF	31	Q5QGS0
EADDIIQEKTMDATQ	SHISAL2B	141	A6NKW6
ENAATDNIAFMITET	KIAA1217	1376	Q5T5P2
ADMDAVDAENQVELE	SCOC	81	Q9UIL1
AFMEAAEITDEDNSI	RACGAP1	441	Q9H0H5
VEMKLAVDEEENADN	TFRC	36	P02786
DKASDFVQEASMLQA	URB1	716	O60287
AVEIAIDNTAFMDEF	STX3	21	Q13277
EVSAEALEMVINNDA	ABTB2	261	Q8N961
EMFAELLQAANTTDD	USP53	206	Q70EK8
ETEQLQAAAMAAEAE	ZBTB14	426	O43829
MDSVAFEDVAVNFTQ	ZNF823	1	P16415
TEAVTVADGDNLENM	ZNF143	31	P52747
DVMLETFQNLASVDD	ZNF555	31	Q8NEP9
MDSVAFEDVDVNFTQ	ZNF136	1	P52737
SAVAEAQKLMVQAAD	NAA35	256	Q5VZE5
CVDVQEESNMEALAA	SLFN12L	186	Q6IEE8
DLEQQAVEFMSTSAV	RAPGEF1	66	Q13905
EAVEMEVQAAAVAVA	TRO	641	Q12816
ADYISADELAQVEQM	RNF123	1216	Q5XPI4
ANVEMAEEAGAENLF	PYGB	696	P11216
QDVEKATSEMNTAED	STAM	11	Q92783
MDAVAFEDVAVNFTQ	ZNF563	1	Q8TA94
MDSVAFEDVAVNFTQ	ZNF101	1	Q8IZC7
DSVDKDAMNAAIQQA	ZNF622	121	Q969S3
QAEGAKIEEDTENMA	VPS37B	111	Q9H9H4
AEAAMEFLQELNSDV	NAE1	86	Q13564
ANVEMAEEAGEENLF	PYGL	696	P06737
ENEGVFSDALMVTQD	ZBTB40	246	Q9NUA8
MDSVAFEDVAVNFTQ	ZNF878	1	C9JN71
LMSQAQESVTFEDVA	ZNF311	56	Q5JNZ3
MEAAAAVVAAEAEVE	LRRCC1	1	Q9C099
GDDTDQEAVAQMLDF	GRIN2A	101	Q12879