Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	metalloendopeptidase activity	ADAMTS10 ADAM15 ADAM2 ADAMTS5 ADAM32	6.84e-05	120	71	5	GO:0004222
GeneOntologyMolecularFunction	receptor ligand activity	SEMA3F CGB1 CGB2 PENK WNT9B PROK1 PRLH CRLF2 SEMA4G	1.34e-04	547	71	9	GO:0048018
GeneOntologyMolecularFunction	signaling receptor activator activity	SEMA3F CGB1 CGB2 PENK WNT9B PROK1 PRLH CRLF2 SEMA4G	1.47e-04	554	71	9	GO:0030546
GeneOntologyMolecularFunction	signaling receptor regulator activity	SEMA3F CGB1 CGB2 PENK WNT9B PROK1 PRLH CRLF2 SEMA4G	3.23e-04	616	71	9	GO:0030545
GeneOntologyMolecularFunction	metallopeptidase activity	ADAMTS10 ADAM15 ADAM2 ADAMTS5 ADAM32	7.31e-04	200	71	5	GO:0008237
GeneOntologyCellularComponent	mitochondrial permeability transition pore complex	BAX PPIF	2.30e-04	7	70	2	GO:0005757
GeneOntologyCellularComponent	pituitary gonadotropin complex	CGB1 CGB2	3.06e-04	8	70	2	GO:0061696
GeneOntologyCellularComponent	mitochondrial matrix	LRPPRC GLRX5 CYP27A1 PUS1 NME4 ELAC2 NDUFS8 PPIF	3.52e-04	523	70	8	GO:0005759
Domain	Peptidase_M12B_N	ADAMTS10 ADAM15 ADAM2 ADAMTS5 ADAM32	3.10e-07	39	69	5	IPR002870
Domain	Pep_M12B_propep	ADAMTS10 ADAM15 ADAM2 ADAMTS5 ADAM32	3.10e-07	39	69	5	PF01562
Domain	DISINTEGRIN_1	ADAMTS10 ADAM15 ADAM2 ADAMTS5 ADAM32	3.53e-07	40	69	5	PS00427
Domain	Reprolysin	ADAMTS10 ADAM15 ADAM2 ADAMTS5 ADAM32	3.53e-07	40	69	5	PF01421
Domain	ADAM_MEPRO	ADAMTS10 ADAM15 ADAM2 ADAMTS5 ADAM32	3.53e-07	40	69	5	PS50215
Domain	DISINTEGRIN_2	ADAMTS10 ADAM15 ADAM2 ADAMTS5 ADAM32	3.53e-07	40	69	5	PS50214
Domain	Peptidase_M12B	ADAMTS10 ADAM15 ADAM2 ADAMTS5 ADAM32	3.53e-07	40	69	5	IPR001590
Domain	Disintegrin_dom	ADAMTS10 ADAM15 ADAM2 ADAMTS5 ADAM32	4.01e-07	41	69	5	IPR001762
Domain	ACR	ADAM15 ADAM2 ADAMTS5 ADAM32	2.81e-06	27	69	4	SM00608
Domain	ADAM_Cys-rich	ADAM15 ADAM2 ADAMTS5 ADAM32	2.81e-06	27	69	4	IPR006586
Domain	MetalloPept_cat_dom	ADAMTS10 ADAM15 ADAM2 ADAMTS5 ADAM32	1.22e-05	81	69	5	IPR024079
Domain	-	ADAMTS10 ADAM15 ADAM2 ADAMTS5 ADAM32	1.22e-05	81	69	5	3.40.390.10
Domain	ADAM_CR	ADAM15 ADAM2 ADAM32	3.78e-05	18	69	3	PF08516
Domain	-	ADAM15 ADAM2 ADAM32	5.26e-05	20	69	3	4.10.70.10
Domain	Disintegrin	ADAM15 ADAM2 ADAM32	6.12e-05	21	69	3	PF00200
Domain	DISIN	ADAM15 ADAM2 ADAM32	6.12e-05	21	69	3	SM00050
Domain	HEMATOPO_REC_S_F1	CSF2RB CRLF2	3.71e-04	8	69	2	PS01355
Domain	Hempt_rcpt_S_F1_CS	CSF2RB CRLF2	4.76e-04	9	69	2	IPR003531
Domain	Disintegrin_CS	ADAM2 ADAM32	1.56e-03	16	69	2	IPR018358
Domain	EGF_3	HSPG2 ADAM15 LRP4 ADAM2 ADAM32	1.77e-03	235	69	5	PS50026
Domain	Semaphorin	SEMA3F SEMA4G	2.45e-03	20	69	2	IPR027231
Domain	EGF_1	HSPG2 ADAM15 LRP4 ADAM2 ADAM32	2.52e-03	255	69	5	PS00022
Domain	EGF_2	HSPG2 ADAM15 LRP4 ADAM2 ADAM32	2.97e-03	265	69	5	PS01186
Domain	ADAM_spacer1	ADAMTS10 ADAMTS5	3.24e-03	23	69	2	IPR010294
Domain	ADAM_spacer1	ADAMTS10 ADAMTS5	3.24e-03	23	69	2	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS10 ADAMTS5	3.52e-03	24	69	2	IPR013273
Domain	ZINC_PROTEASE	ADAMTS10 ADAM15 ADAMTS5	5.71e-03	98	69	3	PS00142
Domain	Sema	SEMA3F SEMA4G	5.84e-03	31	69	2	SM00630
Domain	Semap_dom	SEMA3F SEMA4G	5.84e-03	31	69	2	IPR001627
Domain	Sema	SEMA3F SEMA4G	5.84e-03	31	69	2	PF01403
Domain	SEMA	SEMA3F SEMA4G	5.84e-03	31	69	2	PS51004
Domain	MFS	SLC37A3 SLC2A6 SLC22A31	7.47e-03	108	69	3	PS50850
Domain	MFS_sugar_transport-like	SLC2A6 SLC22A31	7.81e-03	36	69	2	IPR005828
Domain	Sugar_tr	SLC2A6 SLC22A31	7.81e-03	36	69	2	PF00083
Domain	7TM_GPCR_Srsx	ADRA1A OR56B1 S1PR2	8.25e-03	112	69	3	SM01381
Domain	-	LRP4 HHIPL1	9.13e-03	39	69	2	2.120.10.30
Domain	LDLR_class-A_CS	HSPG2 LRP4	9.58e-03	40	69	2	IPR023415
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	ADRA1A CGB1 CGB2 PENK S1PR2 PROK1 PRLH CHRM5	3.13e-05	333	53	8	MM14963
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	MSRB2 LRPPRC GLRX5 METTL9 CYP27A1 PUS1 BAX NME4 ELAC2 SPRYD4 NDUFS8 PPIF	3.01e-06	1136	71	12	34800366
Pubmed	The evolution and genomic landscape of CGB1 and CGB2 genes.	CGB1 CGB2	4.11e-06	2	71	2	17055150
Pubmed	Expression of the human chorionic gonadotropin-beta gene cluster in human pituitaries and alternate use of exon 1.	CGB1 CGB2	4.11e-06	2	71	2	8954017
Pubmed	Human chorionic gonadotropin beta subunit genes CGB1 and CGB2 are transcriptionally active in ovarian cancer.	CGB1 CGB2	4.11e-06	2	71	2	23774837
Pubmed	BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress.	BAX TMBIM6	4.11e-06	2	71	2	15304216
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	SEMA3F HSPG2 ENDOD1 ERBB2 MELTF METTL9 ADAM15 LRP4 TOR1B POMT1 ZZEF1 ELAC2	5.31e-06	1201	71	12	35696571
Pubmed	TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis.	CGB1 CGB2 BAX	5.43e-06	17	71	3	36856110
Pubmed	Molecular cloning, characterization and expression of thyroid-stimulating hormone receptor in channel catfish.	CGB1 CGB2	1.23e-05	3	71	2	19523396
Pubmed	ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers.	ADAMTS10 ADAM15	1.23e-05	3	71	2	15358598
Pubmed	Inner Mitochondrial Membrane Disruption Links Apoptotic and Agonist-Initiated Phosphatidylserine Externalization in Platelets.	BAX PPIF	1.23e-05	3	71	2	28663253
Pubmed	Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues.	CGB1 CGB2	1.23e-05	3	71	2	18048458
Pubmed	[Correlations of HER-2, PCNA, Bcl-2, and Bax expression to prognosis of breast cancer].	ERBB2 BAX	1.23e-05	3	71	2	17626754
Pubmed	Novel insights into the expression of CGB1 & 2 genes by epithelial cancer cell lines secreting ectopic free hCGβ.	CGB1 CGB2	1.23e-05	3	71	2	24778026
Pubmed	The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation.	ERBB2 ADAM15	1.23e-05	3	71	2	18434311
Pubmed	Blockade of the erbB2 receptor induces cardiomyocyte death through mitochondrial and reactive oxygen species-dependent pathways.	ERBB2 BAX	1.23e-05	3	71	2	19017630
Pubmed	A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway.	BAX PPIF	1.23e-05	3	71	2	22719850
Pubmed	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	MSRB2 LRPPRC GLRX5 CYP27A1 BAX NME4 ELAC2 SPRYD4 NDUFS8 PPIF	1.81e-05	926	71	10	20877624
Pubmed	TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation.	CSF2RB CRLF2	2.46e-05	4	71	2	21841801
Pubmed	Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation.	SEMA3F HSPG2	2.46e-05	4	71	2	21924961
Pubmed	Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast.	BAX TMBIM6	2.46e-05	4	71	2	9660918
Pubmed	BI-1 regulates endoplasmic reticulum Ca2+ homeostasis downstream of Bcl-2 family proteins.	BAX TMBIM6	2.46e-05	4	71	2	18299329
Pubmed	Immunophenotyping and oncogene amplifications in tumors of the papilla of Vater.	ERBB2 BAX	2.46e-05	4	71	2	18936968
Pubmed	Mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice.	BAX PPIF	2.46e-05	4	71	2	24325796
Pubmed	Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab.	ERBB2 HLA-G	2.46e-05	4	71	2	34158475
Pubmed	Variability in Streptavidin-Sepharose Matrix Quality Can Significantly Affect Proximity-Dependent Biotinylation (BioID) Data.	LRPPRC GLRX5 NME4 ELAC2 SPRYD4 NDUFS8 PPIF	3.18e-05	438	71	7	32628020
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	SEMA3F HSPG2 ENDOD1 LRPPRC CLCN5 METTL9 HLA-G ADAMTS5 TMBIM6 NME4 NDUFS8 PPIF	3.48e-05	1451	71	12	30550785
Pubmed	Expression and relationship of male reproductive ADAMs in mouse.	ADAM2 ADAM32	4.09e-05	5	71	2	16407499
Pubmed	Androgen-responsive microRNAs in mouse Sertoli cells.	CGB1 CGB2	4.09e-05	5	71	2	22911753
Pubmed	The pleiotropic effects of excessive luteinizing hormone secretion in transgenic mice.	CGB1 CGB2	4.09e-05	5	71	2	17710732
Pubmed	Stress levels of glucocorticoids inhibit LHβ-subunit gene expression in gonadotrope cells.	CGB1 CGB2	4.09e-05	5	71	2	22851703
Pubmed	Luteinizing hormone induction of ovarian tumors: oligogenic differences between mouse strains dictates tumor disposition.	CGB1 CGB2	4.09e-05	5	71	2	10618427
Pubmed	Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation.	CRLF2 NOD2	4.09e-05	5	71	2	21856952
Pubmed	Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations.	GLRX5 PUS1	4.09e-05	5	71	2	19731322
Pubmed	Ovulatory surges of human CG prevent hormone-induced granulosa cell tumor formation leading to the identification of tumor-associated changes in the transcriptome.	CGB1 CGB2	4.09e-05	5	71	2	12040011
Pubmed	An Otx-related homeodomain protein binds an LHbeta promoter element important for activation during gonadotrope maturation.	CGB1 CGB2	4.09e-05	5	71	2	12040015
Pubmed	Transgenic mice with chronically elevated luteinizing hormone are infertile due to anovulation, defects in uterine receptivity, and midgestation pregnancy failure.	CGB1 CGB2	4.09e-05	5	71	2	10342846
Pubmed	Cloning of the mouse gonadotropin beta-subunit-encoding genes, II. Structure of the luteinizing hormone beta-subunit-encoding genes.	CGB1 CGB2	4.09e-05	5	71	2	8543188
Pubmed	Luteinizing hormone beta promoter stimulation by adenylyl cyclase and cooperation with gonadotropin-releasing hormone 1 in transgenic mice and LBetaT2 Cells.	CGB1 CGB2	4.09e-05	5	71	2	17699734
Pubmed	Bax regulates primary necrosis through mitochondrial dynamics.	BAX PPIF	4.09e-05	5	71	2	22493254
Pubmed	Sulfation of LH does not affect intracellular trafficking.	CGB1 CGB2	4.09e-05	5	71	2	19647136
Pubmed	Expression of the beta subunit of chorionic gonadotropin in transgenic mice.	CGB1 CGB2	4.09e-05	5	71	2	7508931
Pubmed	Targeted overexpression of luteinizing hormone causes ovary-dependent functional adenomas restricted to cells of the Pit-1 lineage.	CGB1 CGB2	4.09e-05	5	71	2	12960102
Pubmed	The role of luteinizing hormone-beta gene polymorphism in the onset and progression of puberty in healthy boys.	CGB1 CGB2	4.09e-05	5	71	2	8784083
Pubmed	An i-motif-regulated enhancer, eRNA and adjacent lncRNA affect Lhb expression through distinct mechanisms in a sex-specific context.	CGB1 CGB2	4.09e-05	5	71	2	39158745
Pubmed	Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone.	CGB1 CGB2	4.09e-05	5	71	2	1727547
Pubmed	Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors.	CGB1 CGB2	4.09e-05	5	71	2	7877975
Pubmed	Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility.	CGB1 CGB2	4.09e-05	5	71	2	15569941
Pubmed	Elevated luteinizing hormone in prepubertal transgenic mice causes hyperandrogenemia, precocious puberty, and substantial ovarian pathology.	CGB1 CGB2	4.09e-05	5	71	2	9231809
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	MSRB2 LRPPRC GLRX5 CYP27A1 BAX NME4 ELAC2 SPRYD4 NDUFS8 PPIF	5.12e-05	1047	71	10	18614015
Pubmed	Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition.	CGB1 CGB2	6.13e-05	6	71	2	14871891
Pubmed	Distinct mechanisms involving diverse histone deacetylases repress expression of the two gonadotropin beta-subunit genes in immature gonadotropes, and their actions are overcome by gonadotropin-releasing hormone.	CGB1 CGB2	6.13e-05	6	71	2	17371839
Pubmed	Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death.	BAX PPIF	6.13e-05	6	71	2	17417626
Pubmed	Luteinizing hormone promotes gonadal tumorigenesis in inhibin-deficient mice.	CGB1 CGB2	6.13e-05	6	71	2	18657590
Pubmed	The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19.	CGB1 CGB2	6.13e-05	6	71	2	6204923
Pubmed	Effect of Soluble Adenylyl Cyclase (ADCY10) Inhibitors on the LH-Stimulated cAMP Synthesis in Mltc-1 Leydig Cell Line.	CGB1 CGB2	6.13e-05	6	71	2	33924969
Pubmed	AMP-activated protein kinase is a key intermediary in GnRH-stimulated LHβ gene transcription.	CGB1 CGB2	6.13e-05	6	71	2	23518923
Pubmed	Dependence of uterine cyclooxygenase2 expression on luteinizing hormone signaling.	CGB1 CGB2	6.13e-05	6	71	2	15814897
Pubmed	Ablation of GalNAc-4-sulfotransferase-1 enhances reproduction by altering the carbohydrate structures of luteinizing hormone in mice.	CGB1 CGB2	6.13e-05	6	71	2	18431515
Pubmed	Differential activation of the luteinizing hormone beta-subunit promoter by activin and gonadotropin-releasing hormone: a role for the mitogen-activated protein kinase signaling pathway in LbetaT2 gonadotrophs.	CGB1 CGB2	6.13e-05	6	71	2	13679314
Pubmed	The role of endocannabinoids in the regulation of luteinizing hormone and prolactin release. Differences between the effects of AEA and 2AG.	CGB1 CGB2	6.13e-05	6	71	2	18308464
Pubmed	CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice.	CGB1 CGB2	6.13e-05	6	71	2	22508984
Pubmed	A new role for wilms tumor protein 1: differential activities of + KTS and -KTS variants to regulate LHβ transcription.	CGB1 CGB2	6.13e-05	6	71	2	25617744
Pubmed	A map of the hCG beta-LH beta gene cluster.	CGB1 CGB2	6.13e-05	6	71	2	2422163
Pubmed	The beta subunit of human chorionic gonadotropin is encoded by multiple genes.	CGB1 CGB2	6.13e-05	6	71	2	6194155
Pubmed	Development of a methodology for and assessment of pulsatile luteinizing hormone secretion in juvenile and adult male mice.	CGB1 CGB2	6.13e-05	6	71	2	24092638
Pubmed	Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo.	CGB1 CGB2	6.13e-05	6	71	2	1371113
Pubmed	Free fatty acids induce Lhb mRNA but suppress Fshb mRNA in pituitary LβT2 gonadotropes and diet-induced obesity reduces FSH levels in male mice and disrupts the proestrous LH/FSH surge in female mice.	CGB1 CGB2	6.13e-05	6	71	2	23525221
Pubmed	The role of amino acid neurotransmitters in the regulation of pituitary gonadotropin release in fish.	CGB1 CGB2	6.13e-05	6	71	2	10949077
Pubmed	Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions.	ADAM15 ADAM2	6.13e-05	6	71	2	11882657
Pubmed	Secretoneurin stimulates the production and release of luteinizing hormone in mouse L{beta}T2 gonadotropin cells.	CGB1 CGB2	6.13e-05	6	71	2	21521715
Pubmed	Functional analysis of LHbeta knockout mice.	CGB1 CGB2	6.13e-05	6	71	2	17350160
Pubmed	Increases in luteinizing hormone are associated with declines in cognitive performance.	CGB1 CGB2	6.13e-05	6	71	2	17376589
Pubmed	Development of leydig cells in the insulin-like growth factor-I (igf-I) knockout mouse: effects of igf-I replacement and gonadotropic stimulation.	CGB1 CGB2	6.13e-05	6	71	2	14585811
Pubmed	The lack of estrogen and excess luteinizing hormone are responsible for the female ArKO mouse phenotype.	CGB1 CGB2	6.13e-05	6	71	2	20546829
Pubmed	Maximal activity of the luteinizing hormone beta-subunit gene requires beta-catenin.	CGB1 CGB2	6.13e-05	6	71	2	17244763
Pubmed	The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone.	CGB1 CGB2	6.13e-05	6	71	2	6319099
Pubmed	Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice.	CGB1 CGB2	6.13e-05	6	71	2	17569755
Pubmed	The calcium component of gonadotropin-releasing hormone-stimulated luteinizing hormone subunit gene transcription is mediated by calcium/calmodulin-dependent protein kinase type II.	CGB1 CGB2	6.13e-05	6	71	2	12746302
Pubmed	Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH.	CGB1 CGB2	6.13e-05	6	71	2	12193554
Pubmed	Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.	HSPG2 ERBB2 ADAMTS5	6.53e-05	38	71	3	29743679
Pubmed	Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis.	HSPG2 ERBB2 ADAMTS5	6.53e-05	38	71	3	18267097
Pubmed	Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.	GLRX5 NME4 SPRYD4 NDUFS8 PPIF	6.73e-05	207	71	5	31056398
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	LRPPRC GLRX5 DUSP9 PUS1 BAX TOR1B ELAC2 NDUFS8	7.84e-05	686	71	8	28380382
Pubmed	Early growth response protein 1 binds to the luteinizing hormone-beta promoter and mediates gonadotropin-releasing hormone-stimulated gene expression.	CGB1 CGB2	8.57e-05	7	71	2	10319325
Pubmed	Expression of the pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1R) potentiates the effects of GnRH on gonadotropin subunit gene expression.	CGB1 CGB2	8.57e-05	7	71	2	21658369
Pubmed	Disruption of the single copy gonadotropin-releasing hormone receptor in mice by gene trap: severe reduction of reproductive organs and functions in developing and adult mice.	CGB1 CGB2	8.57e-05	7	71	2	20068010
Pubmed	Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice.	CGB1 CGB2	8.57e-05	7	71	2	12748296
Pubmed	Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3.	ADAM15 ADAM2	8.57e-05	7	71	2	14516789
Pubmed	Biphasic Roles of Clock Genes and Bone Morphogenetic Proteins in Gonadotropin Expression by Mouse Gonadotrope Cells.	CGB1 CGB2	8.57e-05	7	71	2	34681844
Pubmed	Ovulation involves the luteinizing hormone-dependent activation of G(q/11) in granulosa cells.	CGB1 CGB2	8.57e-05	7	71	2	23836924
Pubmed	Cyclic GMP signaling is involved in the luteinizing hormone-dependent meiotic maturation of mouse oocytes.	CGB1 CGB2	8.57e-05	7	71	2	19474061
Pubmed	Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21.	ERBB2 WNT9B	8.57e-05	7	71	2	9441749
Pubmed	Assignment of the genes for the alpha and beta subunits of thyrotropin to different mouse chromosomes.	CGB1 CGB2	8.57e-05	7	71	2	6582507
Pubmed	FOXO1 transcription factor inhibits luteinizing hormone β gene expression in pituitary gonadotrope cells.	CGB1 CGB2	8.57e-05	7	71	2	22865884
Pubmed	Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone.	CGB1 CGB2	8.57e-05	7	71	2	6690982
Pubmed	Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2.	CGB1 CGB2	8.57e-05	7	71	2	17299135
Pubmed	Anterior pituitary development: short tales from dwarf mice.	CGB1 CGB2	8.57e-05	7	71	2	1505020
Pubmed	Stress rapidly suppresses in vivo LH pulses and increases activation of RFRP-3 neurons in male mice.	CGB1 CGB2	8.57e-05	7	71	2	30382693
Pubmed	Embryonic expression of the luteinizing hormone beta gene appears to be coupled to the transient appearance of p8, a high mobility group-related transcription factor.	CGB1 CGB2	8.57e-05	7	71	2	12429736
Pubmed	PPARγ co-activator-1α co-activates steroidogenic factor 1 to stimulate the synthesis of luteinizing hormone and aldosterone.	CGB1 CGB2	8.57e-05	7	71	2	21108604
Interaction	MRM1 interactions	LRPPRC GLRX5 PUS1 NME4 ZZEF1 ELAC2 SPRYD4 NDUFS8 PPIF	2.29e-06	350	67	9	int:MRM1
Interaction	TRMT61B interactions	LRPPRC GLRX5 NME4 ELAC2 SPRYD4 NDUFS8 PPIF SHISA3	4.14e-06	281	67	8	int:TRMT61B
Interaction	DCAKD interactions	OR1M1 HLA-G TMEM9B CRLF2 SHISA3	9.87e-06	86	67	5	int:DCAKD
Interaction	CRYZ interactions	LRPPRC GLRX5 NME4 ELAC2 NDUFS8 PPIF	1.53e-05	160	67	6	int:CRYZ
Interaction	OTC interactions	LRPPRC NME4 ELAC2 NDUFS8 PPIF	2.49e-05	104	67	5	int:OTC
Interaction	PMPCA interactions	LRPPRC GLRX5 CGB2 NME4 ELAC2 SPRYD4 NDUFS8 PPIF	3.95e-05	384	67	8	int:PMPCA
Interaction	MTRES1 interactions	LRPPRC PUS1 NME4 ZZEF1 ELAC2 NDUFS8 PPIF	4.83e-05	289	67	7	int:MTRES1
Interaction	VTI1A interactions	ENDOD1 CLCN5 TMBIM6 TMEM9B	7.30e-05	67	67	4	int:VTI1A
Interaction	FASTKD3 interactions	LRPPRC NME4 ELAC2 NDUFS8 PPIF	8.37e-05	134	67	5	int:FASTKD3
Interaction	TEFM interactions	LRPPRC NME4 ZZEF1 ELAC2 NDUFS8 PPIF	9.28e-05	221	67	6	int:TEFM
Cytoband	9q34	SLC2A6 NELFB TOR1B	8.31e-05	54	71	3	9q34
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	SLC2A6 ANAPC2 NELFB TOR1B POMT1	1.53e-04	325	71	5	chr9q34
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	ADAM15 ADAM2 ADAM32	5.90e-05	27	51	3	47
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS10 ADAMTS5	1.29e-03	19	51	2	50
GeneFamily	Immunoglobulin like domain containing\|Semaphorins	SEMA3F SEMA4G	1.43e-03	20	51	2	736
Disease	Benign neoplasm of stomach	ERBB2 UBR5	5.98e-04	17	63	2	C0153943
Disease	Cannabis Dependence	ADRA1A PENK	5.98e-04	17	63	2	C0006870
Disease	allergic rhinitis (is_marker_for)	HLA-G NOD2	5.98e-04	17	63	2	DOID:4481 (is_marker_for)
Disease	Neoplasm of uncertain or unknown behavior of stomach	ERBB2 UBR5	5.98e-04	17	63	2	C0496905
Disease	Carcinoma in situ of stomach	ERBB2 UBR5	5.98e-04	17	63	2	C0154060
Disease	haptoglobin measurement	ZNF19 HPR	9.18e-04	21	63	2	EFO_0004640
Disease	Stomach Carcinoma	ERBB2 UBR5	9.18e-04	21	63	2	C0699791
Disease	cervical squamous cell carcinoma (is_marker_for)	BAX TMBIM6	1.01e-03	22	63	2	DOID:3744 (is_marker_for)
Disease	eosinophil percentage of leukocytes	CSF2RB ADAM15 ANAPC2 HLA-G BAX TOX2 CRLF2	1.04e-03	746	63	7	EFO_0007991
Disease	middle cerebral artery infarction (biomarker_via_orthology)	HPR BAX NOD2	1.05e-03	93	63	3	DOID:3525 (biomarker_via_orthology)
Disease	prostate carcinoma (is_marker_for)	BAX TMBIM6	1.10e-03	23	63	2	DOID:10286 (is_marker_for)
Disease	Adenocarcinoma of large intestine	ERBB2 UBR5 BAX	1.15e-03	96	63	3	C1319315
Disease	colon adenocarcinoma (is_implicated_in)	UBR5 BAX	1.41e-03	26	63	2	DOID:234 (is_implicated_in)
Disease	isthmus cingulate cortex volume measurement	GLRX5 ADRA1A	1.41e-03	26	63	2	EFO_0010310
Disease	hypertension (biomarker_via_orthology)	HSPG2 ADRA1A HPR BAX	1.42e-03	227	63	4	DOID:10763 (biomarker_via_orthology)
Disease	congestive heart failure (biomarker_via_orthology)	ERBB2 HPR BAX	1.57e-03	107	63	3	DOID:6000 (biomarker_via_orthology)
Disease	Streptozotocin Diabetes	ADRA1A BAX S1PR2	1.61e-03	108	63	3	C0038433
Disease	Diabetes Mellitus, Experimental	ADRA1A BAX S1PR2	1.61e-03	108	63	3	C0011853
Disease	Alloxan Diabetes	ADRA1A BAX S1PR2	1.61e-03	108	63	3	C0002152
Disease	MITOCHONDRIAL COMPLEX I DEFICIENCY	ELAC2 NDUFS8	1.88e-03	30	63	2	C1838979
Disease	Marijuana Abuse	PENK CHRM5	1.88e-03	30	63	2	C0024809

Protein segments in the cluster

Peptide	Gene	Start	Entry
MELAALCRWGLLLAL	ERBB2	1	P04626
LLEKWTRLGLLMGTG	ANAPC2	131	Q9UJX6
MRLALLWALGLLGAG	ADAM15	1	Q13444
MWRVLFLLSGLGGLR	ADAM2	1	Q99965
MLLGWASLLLCAFRL	ADAMTS5	1	Q9UNA0
RRGLMALLCVWALSL	ADRA1A	141	P35348
RLLLLLLLSMGGTWA	CGB1	36	A6NKQ9
MFRLWLLLAGLCGLL	ADAM32	1	Q8TC27
LSMLGADKLGRLWRL	CDAN1	531	Q8IWY9
QILRWALALGLGLMF	ADAMTS10	6	Q9H324
MGWRAAGALLLALLL	HSPG2	1	P98160
MARFLTLCTWLLLLG	PENK	1	P01210
WMIGCDLGSDGRLLR	HLA-G	121	P17693
MARARAGALLALWVL	HHIPL1	1	Q96JK4
MSDLGAVISLLLWGR	HPR	1	P00739
MGTARWLALGSLFAL	ENDOD1	1	O94919
QLMALSWLNRGALGL	OR14K1	141	Q8NGZ2
RMNLSCWLLGAADGL	OR2T8	141	A6NH00
GRLVLLCSLLGMLWE	PCDHGA9	11	Q9Y5G4
LCSLLGMLWEARASQ	PCDHGA9	16	Q9Y5G4
LAWLGMGSDLSLIIL	OR56B1	211	Q8NGI3
MEGLGRSCLWLRREL	DUSP9	1	Q99956
LLRLLALGQGAWDMI	NELFB	341	Q8WX92
RRLGLDWCLITMGKS	PMS2P11	241	Q13670
GDLISRGLEKMLWAR	EVC2	1201	Q86UK5
MRLLAGWLCLSLASV	METTL9	1	Q9H1A3
MAALLRSARWLLRAG	LRPPRC	1	P42704
MGRLVLLWGAAVFLL	CRLF2	1	Q9HC73
GLWMLLLGRTLTGFA	SLC2A6	131	Q9UGQ3
ARTLLWTELFRGLGM	NDUFS8	56	O00217
LAWTLMGSDLGLIIL	OR56B2P	211	Q8NGI1
ALTGMGLLSRLWRLT	POMT1	21	Q9Y6A1
SLWLRGLRMCTPLGR	PROK1	41	P58294
LLLLLLSMGGTWASK	CGB2	6	Q6NT52
GLLSMALLALCWERS	CSF2RB	6	P32927
RTQAGWLLLGALMTL	HEATR5B	551	Q9P2D3
MSGSLGRAAAALLRW	GLRX5	1	Q86SX6
IMGWTLDFLRERLLG	BAX	136	Q07812
SGWLLMLLIGLLSGS	CLCN5	126	P51795
MAALGCARLRWALRG	CYP27A1	1	Q02318
AGLLSALGSLILMIW	TMBIM6	56	P55061
DWRLLQGLGALMSGL	SLC22A31	241	A6NKX4
CRMLLLIGASWLISL	S1PR2	146	O95136
RLWGLQQGMLSRLSL	LINGO4	71	Q6UY18
MSLRLCRLLVGALWA	OR1M1	136	Q8NGA1
MLVAGLLLWASLLTG	SEMA3F	1	Q13275
MALLFARSLRLCRWG	SPRYD4	1	Q8WW59
MRGPSGALWLLLALR	MELTF	1	P08582
MGLQLRALLGAFGRW	PUS1	1	Q9Y606
MGGLFWRSALRGLRC	NME4	1	O00746
VALGLMLLSWLHGRS	PIGQ	286	Q9BRB3
MRALLALCLLLGWLR	SHISA3	1	A0PJX4
MLALRCGSRWLGLLS	PPIF	1	P30405
ILMGRWALGSLACDL	CHRM5	91	P08912
MATLWGGLLRLGSLL	TMEM9B	1	Q9NQ34
ALISLLERGDMAWGL	ZNF19	61	P17023
MWALCSLLRSAAGRT	ELAC2	1	Q9BQ52
ARALWLLNGSMGLSD	SEMA4G	591	Q9NTN9
RGRCLLFTEGMWLSA	TMEM179	36	Q6ZVK1
MARLLWLLRGLTLGT	MSRB2	1	Q9Y3D2
TLLHLGRLALWGLGM	NOD2	546	Q9HC29
GDRLNLRWVLSFGMC	SLC37A3	106	Q8NCC5
AWLLCLLMLGLALRG	PRLH	6	P81277
TGSLWSILLMIGILR	SLC7A13	366	Q8TCU3
GMRLGLLLLARHWCI	TOX2	21	Q96NM4
SWGLDLQLLVSRLMG	ZZEF1	1201	O43149
MWSARGAELALLLGK	WDR27	581	A2RRH5
IGDGMRLWDLRTLRC	WDR27	731	A2RRH5
ERWNCSLEGRMGLLK	WNT9B	96	O14905
SMLLWGDAGLSLELR	VRTN	91	Q9H8Y1
MLRAGWLRGAAALAL	TOR1B	1	O14657
SHDMLLGRWRLSLEL	UBR5	2181	O95071
MPWSSRGALLRDLVL	XKR8	1	Q9H6D3
MRRQWGALLLGALLC	LRP4	1	O75096