Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	intraciliary transport particle A	IFT140 IFT122	2.24e-04	8	60	2	GO:0030991
GeneOntologyCellularComponent	acrosomal vesicle	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	3.11e-04	206	60	5	GO:0001669
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31C2 SPATA31A6 SPATA31A5	1.89e-10	12	58	5	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31C2 SPATA31A6 SPATA31A5	1.89e-10	12	58	5	IPR027970
Domain	zf-C2H2_6	ZNF823 ZNF502 ZNF490 ZNF20 ZNF780B ZNF546	4.18e-04	314	58	6	PF13912
Domain	-	KDM5B ARID5B	9.70e-04	15	58	2	1.10.150.60
Domain	BRIGHT	KDM5B ARID5B	9.70e-04	15	58	2	SM00501
Domain	ARID_dom	KDM5B ARID5B	9.70e-04	15	58	2	IPR001606
Domain	ARID	KDM5B ARID5B	9.70e-04	15	58	2	PS51011
Domain	ARID	KDM5B ARID5B	9.70e-04	15	58	2	PF01388
Domain	FA58C	CNTNAP1 SSPOP	1.92e-03	21	58	2	SM00231
Domain	FA58C_3	CNTNAP1 SSPOP	1.92e-03	21	58	2	PS50022
Domain	FA58C_1	CNTNAP1 SSPOP	1.92e-03	21	58	2	PS01285
Domain	FA58C_2	CNTNAP1 SSPOP	1.92e-03	21	58	2	PS01286
Domain	F5_F8_type_C	CNTNAP1 SSPOP	2.50e-03	24	58	2	PF00754
Domain	FA58C	CNTNAP1 SSPOP	2.50e-03	24	58	2	IPR000421
Domain	KRAB	ZNF823 ZNF490 ZNF20 ZNF780B ZNF546	5.02e-03	358	58	5	PS50805
Domain	KRAB	ZNF823 ZNF490 ZNF20 ZNF780B ZNF546	5.02e-03	358	58	5	PF01352
Domain	KRAB	ZNF823 ZNF490 ZNF20 ZNF780B ZNF546	5.70e-03	369	58	5	SM00349
Domain	KRAB	ZNF823 ZNF490 ZNF20 ZNF780B ZNF546	5.76e-03	370	58	5	IPR001909
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	7.72e-14	6	60	5	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	7.72e-14	6	60	5	25930072
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A1 SPATA31A3 SPATA31A7 SPATA31A6 SPATA31A5	5.34e-10	24	60	5	32212159
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ATRN IFT140 SSPOP ADCY9 LARGE1	1.09e-06	105	60	5	9628581
Pubmed	Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing.	CXCR5 PIK3CG	2.93e-06	2	60	2	15294934
Pubmed	Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA.	KDM5B ARID5B	2.93e-06	2	60	2	11478881
Pubmed	Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs.	KDM5B ARID5B	2.93e-06	2	60	2	11483573
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	STK36 IFT140 CLSTN1 SSPOP DSCAML1	3.13e-06	130	60	5	12421765
Pubmed	MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma.	HDAC6 CABIN1	1.75e-05	4	60	2	23974956
Pubmed	PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells.	CXCR5 PIK3CG	1.75e-05	4	60	2	20412587
Pubmed	Cranioectodermal Dysplasia	IFT140 IFT122	4.37e-05	6	60	2	24027799
Pubmed	Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis.	IFT140 IFT122	4.37e-05	6	60	2	29220510
Pubmed	Role for the IFT-A Complex in Selective Transport to the Primary Cilium.	IFT140 IFT122	4.37e-05	6	60	2	27806291
Pubmed	Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein-coupled receptors.	IFT140 IFT122	6.11e-05	7	60	2	27932497
Pubmed	DNA-binding properties of ARID family proteins.	KDM5B ARID5B	6.11e-05	7	60	2	15640446
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ATRN KDM5B HDAC6 COPA CNTNAP1 ARID5B ADNP2 IFT122 CABIN1 DSCAML1	6.42e-05	1285	60	10	35914814
Pubmed	TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.	IFT140 IFT122	1.05e-04	9	60	2	20889716
Pubmed	HDAC6 interacts with PTPN1 to enhance melanoma cells progression.	HDAC6 CNTNAP1	1.31e-04	10	60	2	29278704
Pubmed	14-3-3ε mediates the cell fate decision-making pathways in response of hepatocellular carcinoma to Bleomycin-induced DNA damage.	HDAC6 COPA TSC1	2.07e-04	66	60	3	23472066
Pubmed	Genomic analysis of mouse retinal development.	ARHGAP31 TBC1D1 ADNP2 TSC1 CLSTN1 FAM135A CCNK LARGE1	3.22e-04	1006	60	8	15226823
Pubmed	Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women.	CNTNAP1 ALOX12B	3.91e-04	17	60	2	19372141
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ATRN ADNP2 DSCAML1	4.67e-04	87	60	3	12465718
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	ARID5B TSC1 TWF2 FAM135A PLRG1 ZNF546	5.26e-04	588	60	6	38580884
Pubmed	ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.	IFT140 IFT122	6.61e-04	22	60	2	25294941
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	HDAC6 ADNP2 CLSTN1	7.01e-04	100	60	3	10048485
Pubmed	Phospho-tyrosine dependent protein-protein interaction network.	STK36 IFT140 PLEKHS1 TSC1 C22orf39	7.13e-04	410	60	5	25814554
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZNF490 STK36 ARHGAP31	7.64e-04	103	60	3	10574462
Pubmed	Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle.	ATRN PLRG1	1.07e-03	28	60	2	28655764
Pubmed	Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components.	IFT140 IFT122	1.15e-03	29	60	2	21209331
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	4.68e-05	8	60	2	chr9q12
Cytoband	9p13.1	SPATA31A1 SPATA31A3	4.55e-04	24	60	2	9p13.1
Cytoband	9q34	ENTPD2 TSC1	2.30e-03	54	60	2	9q34
Cytoband	17q21	CNTNAP1 AOC3	3.12e-03	63	60	2	17q21
Cytoband	19p13.2	ZNF823 ZNF490 ZNF20	3.40e-03	229	60	3	19p13.2
GeneFamily	AT-rich interaction domain containing	KDM5B ARID5B	4.44e-04	15	38	2	418
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF823 ZNF502 ZNF490 ZNF20 ZNF780B ADNP2 ZNF546	6.51e-04	718	38	7	28
GeneFamily	Intraflagellar transport proteins\|Tetratricopeptide repeat domain containing	IFT140 IFT122	1.15e-03	24	38	2	615
GeneFamily	WD repeat domain containing	IFT140 COPA IFT122 PLRG1	2.16e-03	262	38	4	362
Coexpression	GSE5589_LPS_VS_LPS_AND_IL6_STIM_MACROPHAGE_45MIN_UP	IFT140 SLC11A1 PIK3CG PAFAH1B3 TWF2 ADCY9	5.33e-06	200	58	6	M6611
Disease	autism spectrum disorder (implicated_via_orthology)	KDM5B CNTNAP1 TSC1 DSCAML1	1.75e-04	152	54	4	DOID:0060041 (implicated_via_orthology)
Disease	RS-10-hydroxywarfarin measurement	ZNF823 PIK3CG DSCAML1	7.79e-04	98	54	3	EFO_0803330
Disease	lymphocyte measurement	TBC1D1 ENTPD2 ARID5B	1.30e-03	117	54	3	EFO_0803546
Disease	asthma, response to diisocyanate	ATRN IFT122 CLSTN1 ADCY9	1.34e-03	261	54	4	EFO_0006995, MONDO_0004979
Disease	celiac disease	CXCR5 ARHGAP31 TLR8	1.61e-03	126	54	3	EFO_0001060
Disease	diverticulitis	CXCR5 SLC25A38	2.10e-03	37	54	2	EFO_1001460
Disease	high grade glioma (is_implicated_in)	KDM5B ENTPD2	2.70e-03	42	54	2	DOID:3070 (is_implicated_in)
Disease	Secondary Biliary Cholangitis	CXCR5 ENTPD2	2.70e-03	42	54	2	C0238065
Disease	Biliary cirrhosis	CXCR5 ENTPD2	2.70e-03	42	54	2	C0023892
Disease	Biliary Cirrhosis, Primary, 1	CXCR5 ENTPD2	2.70e-03	42	54	2	C4551595
Disease	primary immunodeficiency disease (is_implicated_in)	PIK3CG TLR8	2.70e-03	42	54	2	DOID:612 (is_implicated_in)
Disease	nose morphology measurement	TBC1D1 ARID5B DSCAML1 LARGE1	3.10e-03	329	54	4	EFO_0007843
Disease	Primary Ciliary Dyskinesia	STK36 IFT122	3.37e-03	47	54	2	C4551720
Disease	Primary biliary cirrhosis	CXCR5 ENTPD2	3.37e-03	47	54	2	C0008312

Protein segments in the cluster

Peptide	Gene	Start	Entry
RSARHFLHHYYVHGE	C22orf39	61	Q6P5X5
RIVYYYHDADGHFHL	PGM3	281	O95394
AVVRHDLHFHFTARY	CNTNAP1	131	P78357
DRYLAIVHAVHAYRH	CXCR5	146	P32302
LHYDTLATGIIYFHR	CCNK	66	O75909
HHYSLYVHGCRLIFL	CLSTN1	416	O94985
LIYFSYGIRHSLEGH	SLC7A2	596	P52569
VCRYLLHHYLGHFFQ	ATG2A	16	Q2TAZ0
VAHFHYLINSYFGLR	ADNP2	176	Q6IQ32
RRHHSDLYSHYFGGL	AOC3	441	Q16853
SDHTFRHYAYLRDSL	INTS4	566	Q96HW7
IDRDGSTFRHVHYYL	KCTD19	56	Q17RG1
SHHDMYDYLHLSRLG	PAFAH1B3	186	Q15102
GGYSHRTYALSHLIH	KLHL33	471	A6NCF5
FTVHRTHLYFLHYEY	LARGE1	451	O95461
QRLAELYHGYHAIHR	IFT122	946	Q9HBG6
VYDHRTRALYVHGGY	ATRN	506	O75882
LHLYGQHYRVYTHSF	ENTPD2	226	Q9Y5L3
DSFLHHAYRFHYTLC	FAM135A	231	Q9P2D6
IRHYHGHLSAVYGLD	PLRG1	281	O43660
FLAHSSHHHFLYGLL	SLC11A1	526	P49279
EHYRLLHRYCVFSHD	KDM5B	616	Q9UGL1
HYVTRLGHRFINHIF	NUDT7	161	P0C024
RELHIAYRYGEHYDS	OTUD3	171	Q5T2D3
IEEVLFYYSHRLLHH	FAXDC2	181	Q96IV6
YLLHYRQAGHYLHEE	CABIN1	1226	Q9Y6J0
EHRFFITYHGGLYIS	DSCAML1	171	Q8TD84
GHLDYIRTTFFHHEY	COPA	91	P53621
HRYLISTYDDHYNRH	CFAP107	91	Q8N1D5
LNREFEVSYRLHYHG	ADCY9	996	O60503
RYAEFYSHEAIAHLL	ALOX12B	386	O75342
VLYVSLHRYDHGTFF	HDAC6	666	Q9UBN7
VHLHYYGLRDSRSEH	POLR3E	206	Q9NVU0
DRVHLRSTYHRYAGH	IFT140	896	Q96RY7
HRHPFYSEHSRMLSY	SPATA31C2	1096	B4DYI2
FHYRTFDGRHYHFLG	SSPOP	201	A2VEC9
FDGRHYHFLGRCTYL	SSPOP	206	A2VEC9
REHDHIYRGIHSYLR	RNF113B	141	Q8IZP6
HRHLFYSEHGRILSY	SPATA31A6	1246	Q5VVP1
RHLFYSEHGRILSYA	SPATA31A7	1251	Q8IWB4
HHAFLQDLYLRARYH	SIX5	156	Q8N196
IYAALRSIYHSEGHR	SLC25A38	161	Q96DW6
SALYYLHSHRILHRD	STK36	111	Q9NRP7
FYSSPHLHSLYRHTE	ARID5B	831	Q14865
DFYHRLGPHHFLLLY	PIK3CG	86	P48736
FSLSYYKDHHHRGSI	PLEKHS1	51	Q5SXH7
RHLFYSEHGRILSYA	SPATA31A3	1251	Q5VYP0
HYFRIAGVTHHLEFI	TLR8	566	Q9NR97
FYSSYLRHERIHTGE	ZNF823	231	P16415
YLVHLHASVYALFHR	TSC1	176	Q92574
AFRYFSSLHIHERTH	ZNF20	431	P17024
AFLYSTHFRIHERTH	ZNF490	426	Q9ULM2
RHLFYSEHGRILSYA	SPATA31A1	1251	Q5TZJ5
RHLFYSEHGRILSYA	SPATA31A5	1251	Q5VU36
SRLLHDYHRDLYNHL	TBC1D1	941	Q86TI0
FSSRYHLTQHYRIHT	ZNF546	506	Q86UE3
SHYRTLEYLIRHLAH	ARHGAP31	141	Q2M1Z3
FRYHYQLTEHYRIHT	ZNF780B	706	Q9Y6R6
RKYAHLSEHYRIHTG	ZNF502	501	Q8TBZ5
RDAARYHFFLYKHTH	TWF2	231	Q6IBS0
HYHTFYDFIIARARG	FAM50B	246	Q9Y247