Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	galactoside binding	LGALS9C LGALS9B GLB1	1.23e-05	9	107	3	GO:0016936
GeneOntologyMolecularFunction	tRNA (cytidine-3-)-methyltransferase activity	METTL2A METTL2B	1.69e-04	4	107	2	GO:0052735
Domain	SIM_C	SIM1 SIM2	3.25e-05	2	107	2	IPR010578
Domain	SIM_C	SIM1 SIM2	3.25e-05	2	107	2	PF06621
Domain	SIM_C	SIM1 SIM2	3.25e-05	2	107	2	PS51302
Domain	-	PRAMEF7 MXRA5 LRRC57 ECM2 PRAMEF12 PRAMEF8 LGR5 LHCGR GP1BA	9.59e-05	321	107	9	3.80.10.10
Domain	L_dom-like	PRAMEF7 MXRA5 LRRC57 ECM2 PRAMEF12 PRAMEF8 LGR5 LHCGR GP1BA	1.13e-04	328	107	9	IPR032675
Domain	PRAME_family	PRAMEF7 PRAMEF12 PRAMEF8	1.66e-04	19	107	3	IPR026271
Domain	MeTrfase	METTL2A METTL2B	1.94e-04	4	107	2	IPR026113
Domain	Methyltransf_12	METTL2A METTL2B	4.80e-04	6	107	2	PF08242
Domain	Surp	SF3A1 U2SURP	4.80e-04	6	107	2	PF01805
Domain	SWAP	SF3A1 U2SURP	4.80e-04	6	107	2	SM00648
Domain	SURP	SF3A1 U2SURP	4.80e-04	6	107	2	PS50128
Domain	Myb-like_dom	EP400 GON4L	4.80e-04	6	107	2	IPR017877
Domain	Surp	SF3A1 U2SURP	4.80e-04	6	107	2	IPR000061
Domain	Gphrmn_rcpt_fam	LGR5 LHCGR	4.80e-04	6	107	2	IPR002131
Domain	Methyltransf_12	METTL2A METTL2B	4.80e-04	6	107	2	IPR013217
Domain	Pectin_lyase_fold/virulence	CEMIP2 FBXO10	8.90e-04	8	107	2	IPR011050
Domain	Ank	TRPC6 ANKMY1 ASB13 TNNI3K ASB8 ANKRD11	2.01e-03	228	107	6	PF00023
Domain	-	LGALS9C LGALS9B ADGRV1 ADGRG4	2.17e-03	95	107	4	2.60.120.200
Domain	LRRNT	MXRA5 LGR5 LHCGR GP1BA	2.43e-03	98	107	4	IPR000372
Domain	LRRNT	MXRA5 LGR5 LHCGR GP1BA	2.43e-03	98	107	4	SM00013
Domain	LRR_8	MXRA5 LRRC57 ECM2 LGR5 GP1BA	3.04e-03	171	107	5	PF13855
Domain	ANK	TRPC6 ANKMY1 ASB13 TNNI3K ASB8 ANKRD11	3.24e-03	251	107	6	SM00248
Domain	Gal-bind_lectin	LGALS9C LGALS9B	3.25e-03	15	107	2	PF00337
Domain	Gal-bind_lectin	LGALS9C LGALS9B	3.25e-03	15	107	2	SM00908
Domain	GALECTIN	LGALS9C LGALS9B	3.25e-03	15	107	2	PS51304
Domain	Galectin_CRD	LGALS9C LGALS9B	3.25e-03	15	107	2	IPR001079
Domain	GLECT	LGALS9C LGALS9B	3.25e-03	15	107	2	SM00276
Domain	ANK_REPEAT	TRPC6 ANKMY1 ASB13 TNNI3K ASB8 ANKRD11	3.37e-03	253	107	6	PS50088
Domain	Ankyrin_rpt-contain_dom	TRPC6 ANKMY1 ASB13 TNNI3K ASB8 ANKRD11	3.43e-03	254	107	6	IPR020683
Domain	ANK_REP_REGION	TRPC6 ANKMY1 ASB13 TNNI3K ASB8 ANKRD11	3.43e-03	254	107	6	PS50297
Domain	Leu-rich_rpt_typical-subtyp	MXRA5 LRRC57 ECM2 LGR5 GP1BA	3.53e-03	177	107	5	IPR003591
Domain	LRR_TYP	MXRA5 LRRC57 ECM2 LGR5 GP1BA	3.53e-03	177	107	5	SM00369
Domain	Ankyrin_rpt	TRPC6 ANKMY1 ASB13 TNNI3K ASB8 ANKRD11	4.00e-03	262	107	6	IPR002110
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DNHD1 SF3A1 U2SURP SPTLC1 TRIM14 EHD4 DDX10 FANCI TBK1 RCL1 RBM15B UTP20 AFDN HADHB COASY KDM1A CDK2	1.66e-06	1425	107	17	30948266
Pubmed	Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region.	SIM1 SIM2	9.38e-06	2	107	2	9199934
Pubmed	Single-minded--two genes, three chromosomes.	SIM1 SIM2	9.38e-06	2	107	2	9199929
Pubmed	CBB1003, a lysine-specific demethylase 1 inhibitor, suppresses colorectal cancer cells growth through down-regulation of leucine-rich repeat-containing G-protein-coupled receptor 5 expression.	LGR5 KDM1A	9.38e-06	2	107	2	25060070
Pubmed	Overexpression of mSim2 gene in the zona limitans of the diencephalon of segmental trisomy 16 Ts1Cje fetuses, a mouse model for trisomy 21: a novel whole-mount based RNA hybridization study.	SIM1 SIM2	9.38e-06	2	107	2	10837894
Pubmed	Increased protein expression of LHCG receptor and 17α-hydroxylase/17-20-lyase in human polycystic ovaries.	CYP17A1 LHCGR	9.38e-06	2	107	2	24014605
Pubmed	A novel nuclear localization signal in the human single-minded proteins SIM1 and SIM2.	SIM1 SIM2	9.38e-06	2	107	2	14697214
Pubmed	Regulation of colonic epithelial cell homeostasis by mTORC1.	TSC2 LGR5	9.38e-06	2	107	2	32796887
Pubmed	Cell Cycle-Dependent Switch of TopBP1 Functions by Cdk2 and Akt.	TOPBP1 CDK2	9.38e-06	2	107	2	31964753
Pubmed	Transposable elements-mediated recruitment of KDM1A epigenetically silences HNF4A expression to promote hepatocellular carcinoma.	HNF4A KDM1A	9.38e-06	2	107	2	38965210
Pubmed	Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.	PRAMEF7 PRAMEF12 PRAMEF8	1.87e-05	17	107	3	23565261
Pubmed	Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.	PRAMEF7 PRAMEF12 PRAMEF8	1.87e-05	17	107	3	37781892
Pubmed	The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.	PRAMEF7 PRAMEF12 PRAMEF8	2.23e-05	18	107	3	23894331
Pubmed	Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.	PRAMEF7 PRAMEF12 PRAMEF8	2.23e-05	18	107	3	39181896
Pubmed	Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.	PRAMEF7 PRAMEF12 PRAMEF8	2.23e-05	18	107	3	12890732
Pubmed	Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.	PRAMEF7 PRAMEF12 PRAMEF8	2.23e-05	18	107	3	29731491
Pubmed	Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.	PRAMEF7 PRAMEF12 PRAMEF8	2.23e-05	18	107	3	14675769
Pubmed	Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.	PRAMEF7 PRAMEF12 PRAMEF8	2.65e-05	19	107	3	28604677
Pubmed	Galectin-9 is a high affinity IgE-binding lectin with anti-allergic effect by blocking IgE-antigen complex formation.	LGALS9C LGALS9B	2.81e-05	3	107	2	19776007
Pubmed	Galectin-9 regulates follicular helper T cells to inhibit humoral autoimmunity-induced pulmonary fibrosis.	LGALS9C LGALS9B	2.81e-05	3	107	2	33316546
Pubmed	Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectin.	LGALS9C LGALS9B	2.81e-05	3	107	2	9038233
Pubmed	Protective effect of Galectin-9 in murine model of lung emphysema: Involvement of neutrophil migration and MMP-9 production.	LGALS9C LGALS9B	2.81e-05	3	107	2	28704475
Pubmed	BAP1 expression is prognostic in breast and uveal melanoma but not colon cancer and is highly positively correlated with RBM15B and USP19.	BAP1 RBM15B	2.81e-05	3	107	2	30716094
Pubmed	Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis.	LGALS9C LGALS9B	2.81e-05	3	107	2	23836896
Pubmed	Sequence and mapping of galectin-5, a beta-galactoside-binding lectin, found in rat erythrocytes.	LGALS9C LGALS9B	2.81e-05	3	107	2	7890611
Pubmed	Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner.	LGALS9C LGALS9B	2.81e-05	3	107	2	22341088
Pubmed	Galectin-9 Is a Novel Regulator of Epithelial Restitution.	LGALS9C LGALS9B	2.81e-05	3	107	2	32380082
Pubmed	Galectin-9-mediated protection from allo-specific T cells as a mechanism of immune privilege of corneal allografts.	LGALS9C LGALS9B	2.81e-05	3	107	2	23667648
Pubmed	Regulatory T Cell-Mediated Suppression of Inflammation Induced by DR3 Signaling Is Dependent on Galectin-9.	LGALS9C LGALS9B	2.81e-05	3	107	2	28877989
Pubmed	Galectin-9 ameliorates immune complex-induced arthritis by regulating Fc gamma R expression on macrophages.	LGALS9C LGALS9B	2.81e-05	3	107	2	19800850
Pubmed	The effect of Toxoplasma gondii infection on galectin-9 expression in decidual macrophages contributing to dysfunction of decidual NK cells during pregnancy.	LGALS9C LGALS9B	2.81e-05	3	107	2	38987795
Pubmed	Physical mapping of the holoprosencephaly critical region in 21q22.3, exclusion of SIM2 as a candidate gene for holoprosencephaly, and mapping of SIM2 to a region of chromosome 21 important for Down syndrome.	SIM1 SIM2	2.81e-05	3	107	2	7485157
Pubmed	Oncogenic miR-93-5p/Gal-9 axis drives CD8 (+) T-cell inactivation and is a therapeutic target for hepatocellular carcinoma immunotherapy.	LGALS9C LGALS9B	2.81e-05	3	107	2	37105392
Pubmed	cDNA cloning of a murine homologue of Drosophila single-minded, its mRNA expression in mouse development, and chromosome localization.	SIM1 SIM2	2.81e-05	3	107	2	8561800
Pubmed	Galectin-9/Tim-3 pathway mediates dopaminergic neurodegeneration in MPTP-induced mouse model of Parkinson's disease.	LGALS9C LGALS9B	2.81e-05	3	107	2	36479526
Pubmed	Profiling Lgals9 splice variant expression at the fetal-maternal interface: implications in normal and pathological human pregnancy.	LGALS9C LGALS9B	2.81e-05	3	107	2	23242525
Pubmed	Galectin-9 in allergic airway inflammation and hyper-responsiveness in mice.	LGALS9C LGALS9B	2.81e-05	3	107	2	19851072
Pubmed	The Role of Galectin-9 as Mediator of Atopic Dermatitis: Effect on Keratinocytes.	LGALS9C LGALS9B	2.81e-05	3	107	2	33923930
Pubmed	Intracellular Galectin-9 Enhances Proximal TCR Signaling and Potentiates Autoimmune Diseases.	LGALS9C LGALS9B	2.81e-05	3	107	2	31969388
Pubmed	Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia.	LGALS9C LGALS9B	2.81e-05	3	107	2	35241678
Pubmed	Possible regulatory role of galectin-9 on Ascaris suum-induced eosinophilic lung inflammation in mice.	LGALS9C LGALS9B	2.81e-05	3	107	2	22627368
Pubmed	Galectin-9 is required for endometrial regenerative cells to induce long-term cardiac allograft survival in mice.	LGALS9C LGALS9B	2.81e-05	3	107	2	33153471
Pubmed	T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses.	LGALS9C LGALS9B	2.81e-05	3	107	2	22052881
Pubmed	Galectin-9 supports primary T cell transendothelial migration in a glycan and integrin dependent manner.	LGALS9C LGALS9B	2.81e-05	3	107	2	35643073
Pubmed	Galectin-9 functionally impairs natural killer cells in humans and mice.	LGALS9C LGALS9B	2.81e-05	3	107	2	23408620
Pubmed	DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification.	METTL2A METTL2B	2.81e-05	3	107	2	32427860
Pubmed	Galectin-9 Is Critical for Mucosal Adaptive Immunity through the T Helper 17-IgA Axis.	LGALS9C LGALS9B	2.81e-05	3	107	2	29458010
Pubmed	Cooperative Interactions of Oligosaccharide and Peptide Moieties of a Glycopeptide Derived from IgE with Galectin-9.	LGALS9C LGALS9B	2.81e-05	3	107	2	26582205
Pubmed	Developmental regulation, expression, and apoptotic potential of galectin-9, a beta-galactoside binding lectin.	LGALS9C LGALS9B	2.81e-05	3	107	2	9153289
Pubmed	Galectin-9 expands unique macrophages exhibiting plasmacytoid dendritic cell-like phenotypes that activate NK cells in tumor-bearing mice.	LGALS9C LGALS9B	2.81e-05	3	107	2	18974023
Pubmed	Cell surface galectin-9 expressing Th cells regulate Th17 and Foxp3+ Treg development by galectin-9 secretion.	LGALS9C LGALS9B	2.81e-05	3	107	2	23144904
Pubmed	Impaired Gal-9 Dysregulates the PBMC-Induced Th1/Th2 Imbalance in Abortion-Prone Matings.	LGALS9C LGALS9B	2.81e-05	3	107	2	29651447
Pubmed	The N- and C-terminal carbohydrate recognition domains of galectin-9 contribute differently to its multiple functions in innate immunity and adaptive immunity.	LGALS9C LGALS9B	2.81e-05	3	107	2	21146220
Pubmed	Regulation of M1‑type and M2‑type macrophage polarization in RAW264.7 cells by Galectin‑9.	LGALS9C LGALS9B	2.81e-05	3	107	2	28990062
Pubmed	Galectin-9 suppresses tumor metastasis by blocking adhesion to endothelium and extracellular matrices.	LGALS9C LGALS9B	2.81e-05	3	107	2	18579572
Pubmed	Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.	SIM1 SIM2	2.81e-05	3	107	2	24814368
Pubmed	Crystal structure of the galectin-9 N-terminal carbohydrate recognition domain from Mus musculus reveals the basic mechanism of carbohydrate recognition.	LGALS9C LGALS9B	2.81e-05	3	107	2	16990264
Pubmed	Structural analysis of the human galectin-9 N-terminal carbohydrate recognition domain reveals unexpected properties that differ from the mouse orthologue.	LGALS9C LGALS9B	2.81e-05	3	107	2	18005988
Pubmed	Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3.	LGALS9C LGALS9B	2.81e-05	3	107	2	23585851
Pubmed	Galectin-9 ameliorates anti-GBM glomerulonephritis by inhibiting Th1 and Th17 immune responses in mice.	LGALS9C LGALS9B	2.81e-05	3	107	2	24477688
Pubmed	A unique role for galectin-9 in angiogenesis and inflammatory arthritis.	LGALS9C LGALS9B	2.81e-05	3	107	2	29433546
Pubmed	Alarmin function of galectin-9 in murine respiratory tularemia.	LGALS9C LGALS9B	2.81e-05	3	107	2	25898318
Pubmed	Amelioration of bleomycin-induced pulmonary fibrosis via TGF-β-induced Smad and non-Smad signaling pathways in galectin-9-deficient mice and fibroblast cells.	LGALS9C LGALS9B	2.81e-05	3	107	2	31937306
Pubmed	Intestinal epithelial cells express galectin-9 in patients with food allergy that plays a critical role in sustaining allergic status in mouse intestine.	LGALS9C LGALS9B	2.81e-05	3	107	2	21426359
Pubmed	Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis.	LGALS9C LGALS9B	2.81e-05	3	107	2	18282810
Pubmed	Galectin-9 is a suppressor of T and B cells and predicts the immune modulatory potential of mesenchymal stromal cell preparations.	LGALS9C LGALS9B	2.81e-05	3	107	2	24083426
Pubmed	Galectin-9 in synergy with NF-κB inhibition restores immune regulatory capability in dendritic cells of subjects with food allergy.	LGALS9C LGALS9B	2.81e-05	3	107	2	37279535
Pubmed	The protective function of galectin-9 in liver ischemia and reperfusion injury in mice.	LGALS9C LGALS9B	2.81e-05	3	107	2	25931247
Pubmed	Galectin-9 protects mice from the Shwartzman reaction by attracting prostaglandin E2-producing polymorphonuclear leukocytes.	LGALS9C LGALS9B	2.81e-05	3	107	2	17560833
Pubmed	Characterization of msim, a murine homologue of the Drosophila sim transcription factor.	SIM1 SIM2	2.81e-05	3	107	2	8661115
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	TDRD9 SF3A1 U2SURP TEX15 AFDN HADHB JHY	2.92e-05	284	107	7	29459677
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF7 PRAMEF12 PRAMEF8	3.11e-05	20	107	3	26694250
Pubmed	Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.	PRAMEF7 PRAMEF12 PRAMEF8	3.11e-05	20	107	3	16580637
Pubmed	Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.	PRAMEF7 PRAMEF12 PRAMEF8	3.11e-05	20	107	3	21425410
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	GON4L CEMIP2 GLB1 TBK1 AACS AFDN QSER1 ANAPC5 CLEC16A SLC33A1	3.35e-05	650	107	10	38777146
Pubmed	An abundance of X-linked genes expressed in spermatogonia.	PRAMEF7 PRAMEF12 TEX15 PRAMEF8	3.38e-05	59	107	4	11279525
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	SPTLC1 TSC2 DDX10 GLB1 FANCI TBK1 UTP20 UBAC2 HADHB ANAPC5 SLC33A1 CDK2	3.41e-05	942	107	12	31073040
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF7 PRAMEF12 PRAMEF8	4.18e-05	22	107	3	31729367
Pubmed	Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.	PRAMEF7 PRAMEF12 PRAMEF8	4.79e-05	23	107	3	19480014
Pubmed	SARS-Cov-2 spike induces intestinal barrier dysfunction through the interaction between CEACAM5 and Galectin-9.	LGALS9C LGALS9B	5.60e-05	4	107	2	38686388
Pubmed	Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells.	LGALS9C LGALS9B	5.60e-05	4	107	2	22677125
Pubmed	Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators.	LGALS9C LGALS9B	5.60e-05	4	107	2	19234217
Pubmed	Tim-3/Galectin-9 signaling pathway is involved in the cytokine changes in mice with alveolar echinococcosis.	LGALS9C LGALS9B	5.60e-05	4	107	2	35715604
Pubmed	Sim1 and Sim2 expression during chick and mouse limb development.	SIM1 SIM2	5.60e-05	4	107	2	19123137
Pubmed	Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions.	LGALS9C LGALS9B	5.60e-05	4	107	2	19017954
Pubmed	The genetics of human infertility by functional interrogation of SNPs in mice.	TEX15 CDK2	5.60e-05	4	107	2	26240362
Pubmed	Galectin-9: A novel promoter of atherosclerosis progression.	LGALS9C LGALS9B	5.60e-05	4	107	2	36459823
Pubmed	Galectin-9 inhibits TLR7-mediated autoimmunity in murine lupus models.	LGALS9C LGALS9B	5.60e-05	4	107	2	29611821
Pubmed	Lgals9 deficiency ameliorates obesity by modulating redox state of PRDX2.	LGALS9C LGALS9B	5.60e-05	4	107	2	33727589
Pubmed	The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy.	LGALS9C LGALS9B	5.60e-05	4	107	2	25578313
Pubmed	[Expression and significance of galectin-3 and galectin-9 in mice nasal mucosa with allergic rhinitis].	LGALS9C LGALS9B	5.60e-05	4	107	2	18826117
Pubmed	The expression of Galectin-9 correlates with mTOR and AMPK in murine colony-forming erythroid progenitors.	LGALS9C LGALS9B	5.60e-05	4	107	2	38853593
Pubmed	[Expression of Galectin-9 and Tim-3 in lungs of mice with asthma].	LGALS9C LGALS9B	5.60e-05	4	107	2	21575348
Pubmed	Activation of Tim-3-Galectin-9 pathway improves survival of fully allogeneic skin grafts.	LGALS9C LGALS9B	5.60e-05	4	107	2	18346632
Pubmed	Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins.	METTL2A METTL2B	5.60e-05	4	107	2	11738826
Pubmed	Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice.	LGALS9C LGALS9B	5.60e-05	4	107	2	19670381
Pubmed	Recipient T cell TIM-3 and hepatocyte galectin-9 signalling protects mouse liver transplants against ischemia-reperfusion injury.	LGALS9C LGALS9B	5.60e-05	4	107	2	25450716
Pubmed	The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity.	LGALS9C LGALS9B	5.60e-05	4	107	2	16286920
Pubmed	Galectin-9 regulates the threshold of B cell activation and autoimmunity.	LGALS9C LGALS9B	5.60e-05	4	107	2	34369876
Pubmed	Targeting the CD146/Galectin-9 axis protects the integrity of the blood-brain barrier in experimental cerebral malaria.	LGALS9C LGALS9B	5.60e-05	4	107	2	33203936
GeneFamily	PRAME family	PRAMEF7 PRAMEF12 PRAMEF8	1.46e-04	24	78	3	686
Disease	hereditary sensory neuropathy (implicated_via_orthology)	SCN11A SPTLC1	1.06e-04	5	97	2	DOID:0050548 (implicated_via_orthology)
Disease	basophil count, eosinophil count	SCD5 CD200R1 GLB1 UBAC2 N4BP1 CLEC16A	1.48e-04	241	97	6	EFO_0004842, EFO_0005090
Disease	eosinophil percentage of leukocytes	SF3A1 SCD5 SLC39A8 CD200R1 GLB1 RCL1 UBAC2 N4BP1 CLEC16A IL9R	1.75e-04	746	97	10	EFO_0007991
Disease	melanocyte protein PMEL measurement	MAN2A1 CDK2	2.96e-04	8	97	2	EFO_0801792
Disease	sphingomyelin measurement	SPTLC1 HNF4A SLC39A8 ASB8 ANKRD11 UBASH3B	3.20e-04	278	97	6	EFO_0010118
Disease	alopecia areata (is_marker_for)	KDM1A KDM4B	4.73e-04	10	97	2	DOID:986 (is_marker_for)
Disease	Squamous cell carcinoma of the head and neck	TSC2 TNNI3K CDK2	6.77e-04	52	97	3	C1168401
Disease	neutrophil count, eosinophil count	RASA2 SCD5 HNF4A EHD4 TGFBRAP1	7.03e-04	213	97	5	EFO_0004833, EFO_0004842
Disease	Malignant neoplasm of breast	RCE1 CYP17A1 MCF2L2 SPTLC1 SIM1 BAP1 DDX10 LHCGR UTP20 HADHB ANAPC5	8.06e-04	1074	97	11	C0006142
Disease	IGFBP-1 measurement	ANO5 TGFBRAP1	8.15e-04	13	97	2	EFO_0005118
Disease	neutrophil percentage of leukocytes	SCD5 HNF4A EHD4 TGFBRAP1 RCL1 UBASH3B CLEC16A KDM4B	9.18e-04	610	97	8	EFO_0007990
Disease	nausea and vomiting of pregnancy severity measurement	TRPC6 CD200R1	9.49e-04	14	97	2	EFO_0009265
Disease	neutrophil percentage of granulocytes	SCD5 GLB1 UBAC2 N4BP1 CLEC16A	9.54e-04	228	97	5	EFO_0007994
Disease	eosinophil percentage of granulocytes	SCD5 GLB1 UBAC2 N4BP1 CLEC16A	1.07e-03	234	97	5	EFO_0007996
Disease	monocyte count	RASA2 U2SURP TRPC6 GON4L ADGRV1 SCD5 SLC39A8 EHD4 UBASH3B KDM4B METTL2B CREB3L2	1.30e-03	1320	97	12	EFO_0005091
Disease	melanoma	RASA2 BAP1 KDM1A KDM4B CDK2	1.38e-03	248	97	5	C0025202
Disease	theta wave measurement	SLC39A8 CLEC16A	1.41e-03	17	97	2	EFO_0006873
Disease	granulocyte count	RASA2 SCD5 HNF4A EHD4 TGFBRAP1	1.54e-03	254	97	5	EFO_0007987
Disease	gait measurement	SIM1 SLC39A8 TGFBRAP1 KDM4B	1.54e-03	150	97	4	EFO_0007680
Disease	anxiety disorder (implicated_via_orthology)	TSC2 SLC18A2	2.37e-03	22	97	2	DOID:2030 (implicated_via_orthology)
Disease	red blood cell density measurement	EP400 ADGRV1 HNF4A SLC39A8 CHRNB3 CD200R1 RCL1 AFDN UBASH3B	2.47e-03	880	97	9	EFO_0007978
Disease	body weight	DPY19L2 RASA2 GON4L ANO5 ADGRV1 SIM1 LHCGR TNNI3K MKX FGR KDM4B	2.87e-03	1261	97	11	EFO_0004338

Protein segments in the cluster

Peptide	Gene	Start	Entry
QIILPLIISKYTAGP	SLC33A1	356	O00400
SLKPNIPYKTILLST	AFDN	256	P55196
GPLEYPSASLILKAL	EP400	1386	Q96L91
IPSSSKVIPLIGEYL	CHRNB3	286	Q05901
SVGKRLESLPKALYP	C9orf50	316	Q5SZB4
ISYVLGPVRLPLSVK	ANO5	166	Q75V66
YLLDGKPLSKLHIPV	ANKRD11	2476	Q6UB99
PLGISVLPLKSRLYQ	CCDC33	511	Q8N5R6
VPSLILETKGIPYTL	AACS	616	Q86V21
SIYLPKSLTERIPLS	ADGRG4	2606	Q8IZF6
VKLLLSYGAKVNPPL	ASB13	101	Q8WXK3
KYLLGLIKSSPTFLP	FBXO10	271	Q9UK96
KKTYSEPLALEGPLL	ADGRV1	4651	Q8WXG9
PLSGEKYSPKELLAL	BAP1	621	Q92560
YLPLLTKLGSLHPQS	DNHD1	1086	Q96M86
LLLGPTYATPKVLEK	HADHB	351	P55084
PTLYSVKEALLGKPT	AGBL1	666	Q96MI9
DVSKVLLGPLSPYTI	RCL1	311	Q9Y2P8
PEYKTLLISSLSPAL	RBM15B	136	Q8NDT2
YGPLKTLLLKSPDVQ	RASA2	326	Q15283
VEKLPPLYKTLTFSG	QSER1	366	Q2KHR3
ESLPPLLIGKFTLLK	LRRC57	51	Q8N9N7
PLLQGPDITLSKLYK	ANAPC5	66	Q9UJX4
VKGLPLPASLKEYLL	ASB8	271	Q9H765
PPLVYQLLVLSSKGS	FANCI	211	Q9NVI1
SPTYGIPTLLQKILT	OR11H4	271	Q8NGC9
LTRLSLAYLPVKVIP	LHCGR	51	P22888
IFLKKTLYIPILTEP	LYSMD1	76	Q96S90
LTLGLPTPKTDSYLQ	JHY	261	Q6NUN7
PPLGLKVYKILESAS	MAN2A1	711	Q16706
ILLTELITKGRIPYP	FGR	446	P09769
LYPSKSIILSGTVLP	LGALS9C	236	Q6DKI2
LLISTNPKYGAPLVL	KIAA2026	1911	Q5HYC2
LYPSKSIILSGTVLP	LGALS9B	236	Q3B8N2
LPPLLKTESIYLNGL	KCNK2	396	O95069
GPIKSLYPLTFIQVK	GLB1	396	P16278
YKLLPGAVATIVKPL	HNF4A	446	P41235
LPLFKYLKGPSQRLI	MCF2L2	746	Q86YR7
LLLLQPLTDPKLYGS	RCE1	296	Q9Y256
PYPTKTEKILLALGS	MKX	96	Q8IYA7
SYPVPKGSLDIIILI	METTL2B	246	Q6P1Q9
ISPIILKKYGIPFSR	KDM4B	246	O94953
LTGNKSLYIELLPVP	CD200R1	221	Q8TD46
SLYIELLPVPGAKKS	CD200R1	226	Q8TD46
IKIKLDGYELPSSLP	EHD4	511	Q9H223
KATPLRYTKTLLLPV	DPY19L2	486	Q6NUT2
NSVPLLSYLIVSLPK	OOSP4A	161	A0A2R8YFL7
SYPVPKGSLDIIILI	METTL2A	246	Q96IZ6
VGLSKLSLELYPAPL	PRAMEF12	401	O95522
TAYLLDKLLPTLVPG	EFCAB5	171	A4FU69
ILPSLKGKTYLDVPQ	CBLIF	271	P27352
LINFGIYKRIKPLPT	KDM1A	261	O60341
PTKLEPISILYLDKG	BMP10	391	O95393
KYPKSLLSLPLVGSL	CYP17A1	26	P05093
ESRYPLLLPKGVVLK	GON4L	966	Q3T8J9
TYKPGKLDLLPSSLK	ANKMY1	621	Q9P2S6
YLKTGIPPRSIVLLS	CEMIP2	1276	Q9UHN6
PSYLPKSLLHLVLLG	ECM2	551	O94769
YLKGNELKTLPPGLL	GP1BA	146	P07359
SKLPIPEYALSLGLA	DDX10	491	Q13206
LTGIPLPLIKSYLFQ	CDK2	96	P24941
VGLSKLSLELYPAPL	PRAMEF8	401	Q5VWM4
VTLNLLPKLSKPYIT	PSG4	231	Q00888
LPLNLAIKPYLALKG	PMCH	96	P20382
KRTLIAEGYPIPTKL	CREB3L2	271	Q70SY1
LQPLGYEVPSKTLLS	FEZF2	76	Q8TBJ5
PLYISPIKLLIGVIA	LGR5	586	O75473
YAGDPVSKVLLKPLT	RPUSD1	156	Q9UJJ7
LPSRGLLALSLKYVP	SYTL1	396	Q8IYJ3
LSIIKLPPNKDTTYL	UTP20	501	O75691
RPLKPGEVLSILLYL	TMEM132E	301	Q6IEE7
LYPLPKSVLGALIAV	SLC26A9	426	Q7LBE3
FLSPVPGYRKIILST	TDRD9	431	Q8NDG6
YELAKLLPLPSAITS	SIM2	21	Q14190
YELAKLLPLPSAITS	SIM1	21	P81133
VYSLVLIPKAKPLTL	SCD5	61	Q86SK9
IYPPLLSKTLQGTLL	SLC25A53	81	Q5H9E4
LLLTGPTYLLFKLSP	IL9R	281	Q01113
LVEQYTKILIPPKGL	SF3A1	211	Q15459
AKKLYSIILSAPIPE	STX3	56	Q13277
TGTICPLPELVKLKY	SPTLC1	251	O15269
LPHYLLSSKPKSQPL	SPAG17	2031	Q6Q759
TPLPKKIARLYLVSD	U2SURP	586	O15042
LLKSKLLPELLQPYT	COASY	231	Q13057
PKISLPVSLYLLSQV	CLEC16A	306	Q2KHT3
FLLPGKKNLVTISYP	UFSP2	201	Q9NUQ7
VGLSKLSLELYPAPL	PRAMEF7	401	Q5VXH5
TSKGVYILVPLPLEK	TGFBRAP1	301	Q8WUH2
FITNPRTLLGKKPYI	ZNF343	256	Q6P1L6
GALLKYIGPLTITPT	SLC23A2	236	Q9UGH3
PLLKLGVNYLPSIFI	TMC4	386	Q7Z404
LSTYLPQDTLKLLPL	TMEM79	301	Q9BSE2
IYLLLIPLFSEPTKT	PIEZO2	36	Q9H5I5
LKTSPSPERSLLLKY	TRIM14	251	Q14142
TAVPTLLKYGTPQKL	TXNDC17	91	Q9BRA2
GLILTPLIKKSYFPK	SLC39A8	146	Q9C0K1
AIVSYIPGITIKLLP	SCN11A	206	Q9UI33
YKAPLSKSLLLVPSA	UBAC2	11	Q8NBM4
PLSITNKTLIYILGL	UBAC2	156	Q8NBM4
VLYLRPTGPLAQKLS	UBASH3B	91	Q8TF42
LVPSPKSLFYLLLKL	TRPC6	766	Q9Y210
PLNLTLIASKKYSIP	TEX15	1321	Q9BXT5
KGTPLTTLLKDPYIL	SLC18A2	281	Q05940
IGYSIPKPISSLLIR	TNNI3K	686	Q59H18
YLVAANLKKPILLPS	TOPBP1	156	Q92547
PLNTIGLIYEKISLP	TBK1	386	Q9UHD2
GLLVILQTKLYTLPA	TSC2	566	P49815
LSLLLGYLKLLGPKI	TTI1	401	O43156
ILLPRTVSLKTEGPY	MXRA5	1276	Q9NR99
KVIKVYGPSTEPLLL	N4BP1	366	O75113
LLIHPKTKDLLTTYP	MYO7B	2036	Q6PIF6