Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K9me2/H3K9me3 demethylase activity	KDM4A KDM4C	4.46e-05	6	35	2	GO:0140684
GeneOntologyMolecularFunction	translation termination factor activity	GSPT2 GSPT1	6.23e-05	7	35	2	GO:0008079
GeneOntologyMolecularFunction	translation release factor activity	GSPT2 GSPT1	6.23e-05	7	35	2	GO:0003747
GeneOntologyMolecularFunction	histone H3K36 demethylase activity	KDM4A KDM4C	1.63e-04	11	35	2	GO:0051864
GeneOntologyMolecularFunction	dynein light chain binding	DYNC1I1 DYNC1I2	1.95e-04	12	35	2	GO:0045503
GeneOntologyMolecularFunction	histone H3K9 demethylase activity	KDM4A KDM4C	2.68e-04	14	35	2	GO:0032454
GeneOntologyMolecularFunction	GTPase activity	GSPT2 SEPTIN9 SEPTIN12 GSPT1 EEF1A2	3.01e-04	341	35	5	GO:0003924
GeneOntologyMolecularFunction	dynein heavy chain binding	DYNC1I1 DYNC1I2	3.99e-04	17	35	2	GO:0045504
GeneOntologyMolecularFunction	translation factor activity, RNA binding	GSPT2 GSPT1 EEF1A2	4.42e-04	85	35	3	GO:0008135
GeneOntologyMolecularFunction	GTP binding	GSPT2 SEPTIN9 SEPTIN12 GSPT1 EEF1A2	6.02e-04	397	35	5	GO:0005525
GeneOntologyMolecularFunction	guanyl ribonucleotide binding	GSPT2 SEPTIN9 SEPTIN12 GSPT1 EEF1A2	9.46e-04	439	35	5	GO:0032561
GeneOntologyMolecularFunction	guanyl nucleotide binding	GSPT2 SEPTIN9 SEPTIN12 GSPT1 EEF1A2	9.46e-04	439	35	5	GO:0019001
GeneOntologyMolecularFunction	translation regulator activity, nucleic acid binding	GSPT2 GSPT1 EEF1A2	9.86e-04	112	35	3	GO:0090079
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM4A KDM4C	1.10e-03	28	35	2	GO:0141052
GeneOntologyMolecularFunction	histone demethylase activity	KDM4A KDM4C	1.34e-03	31	35	2	GO:0032452
GeneOntologyMolecularFunction	protein demethylase activity	KDM4A KDM4C	1.43e-03	32	35	2	GO:0140457
GeneOntologyMolecularFunction	demethylase activity	KDM4A KDM4C	2.70e-03	44	35	2	GO:0032451
GeneOntologyMolecularFunction	2-oxoglutarate-dependent dioxygenase activity	KDM4A KDM4C	5.79e-03	65	35	2	GO:0016706
GeneOntologyMolecularFunction	microtubule motor activity	DYNC1I1 DYNC1I2	6.69e-03	70	35	2	GO:0003777
GeneOntologyCellularComponent	translation release factor complex	GSPT2 GSPT1	8.64e-06	3	36	2	GO:0018444
GeneOntologyCellularComponent	septin complex	SEPTIN9 SEPTIN12	2.59e-04	14	36	2	GO:0031105
GeneOntologyCellularComponent	septin ring	SEPTIN9 SEPTIN12	2.59e-04	14	36	2	GO:0005940
GeneOntologyCellularComponent	septin cytoskeleton	SEPTIN9 SEPTIN12	3.41e-04	16	36	2	GO:0032156
GeneOntologyCellularComponent	cytoplasmic dynein complex	DYNC1I1 DYNC1I2	7.77e-04	24	36	2	GO:0005868
GeneOntologyCellularComponent	pericentric heterochromatin	KDM4A KDM4C	1.38e-03	32	36	2	GO:0005721
GeneOntologyCellularComponent	dynein complex	DYNC1I1 DYNC1I2	3.90e-03	54	36	2	GO:0030286
Domain	Transl_elong_EFTu/EF1A_C	GSPT2 GSPT1 EEF1A2	2.80e-07	8	33	3	IPR004160
Domain	GTP_EFTU_D3	GSPT2 GSPT1 EEF1A2	2.80e-07	8	33	3	PF03143
Domain	G_TR_CS	GSPT2 GSPT1 EEF1A2	4.19e-07	9	33	3	IPR031157
Domain	Transl_elong_EF1A/Init_IF2_C	GSPT2 GSPT1 EEF1A2	5.98e-07	10	33	3	IPR009001
Domain	EGF_3	SCUBE1 STAB2 SCUBE2	1.09e-06	12	33	3	PF12947
Domain	EGF_dom	SCUBE1 STAB2 SCUBE2	1.09e-06	12	33	3	IPR024731
Domain	G_TR_1	GSPT2 GSPT1 EEF1A2	1.42e-06	13	33	3	PS00301
Domain	EGF_CA	SCUBE1 STAB2 SCUBE2 F12 CRB2	2.25e-06	122	33	5	SM00179
Domain	EGF-like_Ca-bd_dom	SCUBE1 STAB2 SCUBE2 F12 CRB2	2.43e-06	124	33	5	IPR001881
Domain	DYNC1I1/DYNC1I2	DYNC1I1 DYNC1I2	3.03e-06	2	33	2	IPR025956
Domain	Dynein_IC2	DYNC1I1 DYNC1I2	3.03e-06	2	33	2	PF11540
Domain	EFTu-like_2	GSPT2 GSPT1 EEF1A2	4.03e-06	18	33	3	IPR004161
Domain	GTP_EFTU_D2	GSPT2 GSPT1 EEF1A2	4.03e-06	18	33	3	PF03144
Domain	G_TR_2	GSPT2 GSPT1 EEF1A2	4.03e-06	18	33	3	PS51722
Domain	TF_GTP-bd_dom	GSPT2 GSPT1 EEF1A2	4.78e-06	19	33	3	IPR000795
Domain	EPHD	MLLT6 KDM4A KDM4C	7.56e-06	22	33	3	PS51805
Domain	Transl_B-barrel	GSPT2 GSPT1 EEF1A2	1.43e-05	27	33	3	IPR009000
Domain	EGF_3	SCUBE1 STAB2 SCUBE2 F12 CRB2	5.38e-05	235	33	5	PS50026
Domain	EGF	SCUBE1 STAB2 SCUBE2 F12 CRB2	5.38e-05	235	33	5	SM00181
Domain	EGF	STAB2 SCUBE2 F12 CRB2	6.94e-05	126	33	4	PF00008
Domain	EGF-like_dom	SCUBE1 STAB2 SCUBE2 F12 CRB2	7.08e-05	249	33	5	IPR000742
Domain	EGF_1	SCUBE1 STAB2 SCUBE2 F12 CRB2	7.92e-05	255	33	5	PS00022
Domain	EGF-like_CS	SCUBE1 STAB2 SCUBE2 F12 CRB2	8.84e-05	261	33	5	IPR013032
Domain	EGF_2	SCUBE1 STAB2 SCUBE2 F12 CRB2	9.49e-05	265	33	5	PS01186
Domain	JmjN	KDM4A KDM4C	1.35e-04	10	33	2	PF02375
Domain	JmjN	KDM4A KDM4C	1.35e-04	10	33	2	SM00545
Domain	JMJN	KDM4A KDM4C	1.35e-04	10	33	2	PS51183
Domain	JmjN	KDM4A KDM4C	1.35e-04	10	33	2	IPR003349
Domain	Ephrin_rec_like	SCUBE1 SCUBE2	1.65e-04	11	33	2	PF07699
Domain	zf-C2H2	PRDM9 ZFP69B ZNF229 ZNF592 ZNF674 ZNF710 ZNF2	1.73e-04	693	33	7	PF00096
Domain	Septin	SEPTIN9 SEPTIN12	2.33e-04	13	33	2	PF00735
Domain	G_SEPTIN_dom	SEPTIN9 SEPTIN12	2.33e-04	13	33	2	IPR030379
Domain	G_SEPTIN	SEPTIN9 SEPTIN12	2.33e-04	13	33	2	PS51719
Domain	Septin	SEPTIN9 SEPTIN12	2.72e-04	14	33	2	IPR016491
Domain	ZINC_FINGER_C2H2_2	PRDM9 ZFP69B ZNF229 ZNF592 ZNF674 ZNF710 ZNF2	3.42e-04	775	33	7	PS50157
Domain	ZINC_FINGER_C2H2_1	PRDM9 ZFP69B ZNF229 ZNF592 ZNF674 ZNF710 ZNF2	3.48e-04	777	33	7	PS00028
Domain	VWFD	MUC2 SUSD2	3.58e-04	16	33	2	PS51233
Domain	VWD	MUC2 SUSD2	3.58e-04	16	33	2	SM00216
Domain	VWF_type-D	MUC2 SUSD2	3.58e-04	16	33	2	IPR001846
Domain	VWD	MUC2 SUSD2	3.58e-04	16	33	2	PF00094
Domain	KRAB	PRDM9 ZFP69B ZNF229 ZNF674 ZNF2	3.84e-04	358	33	5	PF01352
Domain	Znf_C2H2-like	PRDM9 ZFP69B ZNF229 ZNF592 ZNF674 ZNF710 ZNF2	4.02e-04	796	33	7	IPR015880
Domain	Znf_C2H2	PRDM9 ZFP69B ZNF229 ZNF592 ZNF674 ZNF710 ZNF2	4.31e-04	805	33	7	IPR007087
Domain	ZnF_C2H2	PRDM9 ZFP69B ZNF229 ZNF592 ZNF674 ZNF710 ZNF2	4.40e-04	808	33	7	SM00355
Domain	KRAB	PRDM9 ZFP69B ZNF229 ZNF674 ZNF2	4.41e-04	369	33	5	SM00349
Domain	KRAB	PRDM9 ZFP69B ZNF229 ZNF674 ZNF2	4.46e-04	370	33	5	IPR001909
Domain	PHD	MLLT6 KDM4A KDM4C	5.15e-04	89	33	3	SM00249
Domain	Znf_PHD	MLLT6 KDM4A KDM4C	5.49e-04	91	33	3	IPR001965
Domain	ZF_PHD_2	MLLT6 KDM4A KDM4C	6.23e-04	95	33	3	PS50016
Domain	ZF_PHD_1	MLLT6 KDM4A KDM4C	6.42e-04	96	33	3	PS01359
Domain	EGF_Ca-bd_CS	SCUBE1 SCUBE2 CRB2	6.62e-04	97	33	3	IPR018097
Domain	EGF_CA	SCUBE1 SCUBE2 CRB2	7.02e-04	99	33	3	PS01187
Domain	ASX_HYDROXYL	SCUBE1 SCUBE2 CRB2	7.23e-04	100	33	3	PS00010
Domain	TUDOR	KDM4A KDM4C	7.48e-04	23	33	2	PS50304
Domain	JmjC	KDM4A KDM4C	8.15e-04	24	33	2	PF02373
Domain	EGF-type_Asp/Asn_hydroxyl_site	SCUBE1 SCUBE2 CRB2	8.57e-04	106	33	3	IPR000152
Domain	Ephrin_rec_like	SCUBE1 SCUBE2	8.85e-04	25	33	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	SCUBE1 SCUBE2	8.85e-04	25	33	2	IPR011641
Domain	cEGF	SCUBE1 SCUBE2	9.58e-04	26	33	2	IPR026823
Domain	cEGF	SCUBE1 SCUBE2	9.58e-04	26	33	2	PF12662
Domain	TUDOR	KDM4A KDM4C	1.03e-03	27	33	2	SM00333
Domain	-	PRDM9 ZFP69B ZNF229 ZNF674 ZNF710 ZNF2	1.08e-03	679	33	6	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	PRDM9 ZFP69B ZNF229 ZNF674 ZNF710 ZNF2	1.21e-03	694	33	6	IPR013087
Domain	Tudor	KDM4A KDM4C	1.28e-03	30	33	2	IPR002999
Domain	JMJC	KDM4A KDM4C	1.45e-03	32	33	2	PS51184
Domain	JmjC_dom	KDM4A KDM4C	1.45e-03	32	33	2	IPR003347
Domain	JmjC	KDM4A KDM4C	1.54e-03	33	33	2	SM00558
Domain	zf-C2H2_6	PRDM9 ZFP69B ZNF229 ZNF710	2.18e-03	314	33	4	PF13912
Domain	Znf_FYVE_PHD	MLLT6 KDM4A KDM4C	2.19e-03	147	33	3	IPR011011
Domain	Growth_fac_rcpt_	SCUBE1 STAB2 SCUBE2	2.59e-03	156	33	3	IPR009030
Domain	CUB	SCUBE1 SCUBE2	3.38e-03	49	33	2	PF00431
Domain	KRAB	ZFP69B ZNF229 ZNF674 ZNF2	3.50e-03	358	33	4	PS50805
Domain	CUB	SCUBE1 SCUBE2	3.52e-03	50	33	2	SM00042
Domain	-	SCUBE1 SCUBE2	3.80e-03	52	33	2	2.60.120.290
Domain	CUB	SCUBE1 SCUBE2	3.94e-03	53	33	2	PS01180
Domain	CUB_dom	SCUBE1 SCUBE2	4.55e-03	57	33	2	IPR000859
Pathway	REACTOME_EUKARYOTIC_TRANSLATION_TERMINATION	GSPT2 GSPT1	6.10e-05	6	29	2	MM15419
Pubmed	Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human.	DYNC1I1 DYNC1I2	1.04e-06	2	36	2	10049579
Pubmed	Functional role of Tia1/Pub1 and Sup35 prion domains: directing protein synthesis machinery to the tubulin cytoskeleton.	GSPT2 GSPT1	1.04e-06	2	36	2	24981173
Pubmed	Structural investigations of the nickel-induced inhibition of truncated constructs of the JMJD2 family of histone demethylases using X-ray absorption spectroscopy.	KDM4A KDM4C	1.04e-06	2	36	2	23692052
Pubmed	Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation.	GSPT2 GSPT1	1.04e-06	2	36	2	15987998
Pubmed	Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts.	DYNC1I1 DYNC1I2	1.04e-06	2	36	2	20657784
Pubmed	Identification of a novel family of cell-surface proteins expressed in human vascular endothelium.	SCUBE1 SCUBE2	3.12e-06	3	36	2	12270931
Pubmed	Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1.	GSPT2 GSPT1	3.12e-06	3	36	2	9712840
Pubmed	The processed isoform of the translation termination factor eRF3 localizes to the nucleus to interact with the ARF tumor suppressor.	GSPT2 GSPT1	3.12e-06	3	36	2	24569073
Pubmed	Diversity within the JMJD2 histone demethylase family.	KDM4A KDM4C	3.12e-06	3	36	2	17207460
Pubmed	Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells.	KDM4A KDM4C	3.12e-06	3	36	2	17611647
Pubmed	The relationship of serum SCUBE-1, -2 and -3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients.	SCUBE1 SCUBE2	3.12e-06	3	36	2	31991528
Pubmed	Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development.	KDM4A KDM4C	3.12e-06	3	36	2	27266524
Pubmed	The histone demethylase JMJD2C is stage-specifically expressed in preimplantation mouse embryos and is required for embryonic development.	KDM4A KDM4C	3.12e-06	3	36	2	19696013
Pubmed	The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance.	KDM4A KDM4C	3.12e-06	3	36	2	31434704
Pubmed	Polypeptide chain release factor eRF3 is a novel molecular partner of survivin.	GSPT2 GSPT1	3.12e-06	3	36	2	23377885
Pubmed	The histone demethylase Kdm4 suppresses activation of hepatic stellate cell by inducing MiR-29 transcription.	KDM4A KDM4C	6.24e-06	4	36	2	31014673
Pubmed	Histone demethylase KDM4C controls tumorigenesis of glioblastoma by epigenetically regulating p53 and c-Myc.	KDM4A KDM4C	6.24e-06	4	36	2	33462212
Pubmed	Histone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells.	KDM4A KDM4C	6.24e-06	4	36	2	26120059
Pubmed	Structural insights into eRF3 and stop codon recognition by eRF1.	GSPT2 GSPT1	6.24e-06	4	36	2	19417105
Pubmed	Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells.	KDM4A KDM4C	6.24e-06	4	36	2	27257215
Pubmed	Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase.	GSPT2 GSPT1	1.04e-05	5	36	2	14685257
Pubmed	Interaction of SQSTM1 with the motor protein dynein--SQSTM1 is required for normal dynein function and trafficking.	DYNC1I1 DYNC1I2	1.04e-05	5	36	2	25015291
Pubmed	Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma.	DYNC1I1 DYNC1I2	1.04e-05	5	36	2	30250299
Pubmed	Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells.	KDM4A KDM4C	1.04e-05	5	36	2	16738407
Pubmed	Scube3 is expressed in multiple tissues during development but is dispensable for embryonic survival in the mouse.	SCUBE1 SCUBE2	1.04e-05	5	36	2	23383134
Pubmed	Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.	KDM4A KDM4C	1.04e-05	5	36	2	21914792
Pubmed	Animal models of lysosomal disease: an overview.	DYNC1I1 DYNC1I2	1.56e-05	6	36	2	9728334
Pubmed	Identification and characterization of JMJD2 family genes in silico.	KDM4A KDM4C	1.56e-05	6	36	2	15138608
Pubmed	The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein.	GSPT2 GSPT1	1.56e-05	6	36	2	10358005
Pubmed	Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.	KDM4A CRB2	1.56e-05	6	36	2	17190600
Pubmed	Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development.	KDM4A KDM4C	2.18e-05	7	36	2	21445275
Pubmed	A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins.	DYNC1I1 DYNC1I2	2.18e-05	7	36	2	11751894
Pubmed	Disruption of Scube2 Impairs Endochondral Bone Formation.	SCUBE1 SCUBE2	2.18e-05	7	36	2	25639508
Pubmed	Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice.	DYNC1I1 DYNC1I2	2.18e-05	7	36	2	12142566
Pubmed	A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system.	DYNC1I1 DYNC1I2	2.18e-05	7	36	2	11163259
Pubmed	HIV-1 uncoating is facilitated by dynein and kinesin 1.	DYNC1I1 DYNC1I2	2.91e-05	8	36	2	25231297
Pubmed	HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.	DYNC1I1 DYNC1I2	2.91e-05	8	36	2	25818806
Pubmed	Mammalian hyperplastic discs homolog EDD regulates miRNA-mediated gene silencing.	GSPT2 GSPT1	3.73e-05	9	36	2	21726813
Pubmed	Transport of the outer dynein arm complex to cilia requires a cytoplasmic protein Lrrc6.	DYNC1I1 DYNC1I2	3.73e-05	9	36	2	27353389
Pubmed	Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.	KDM4A KDM4C	5.70e-05	11	36	2	19144645
Pubmed	Cytoplasmic dynein nomenclature.	DYNC1I1 DYNC1I2	8.07e-05	13	36	2	16260502
Pubmed	Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.	GSPT2 GSPT1	9.41e-05	14	36	2	16452507
Pubmed	Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.	KDM4A KDM4C	9.41e-05	14	36	2	16603238
Pubmed	BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures.	DYNC1I1 DYNC1I2	9.41e-05	14	36	2	22956769
Pubmed	Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse.	DYNC1I1 DYNC1I2	9.41e-05	14	36	2	21471385
Pubmed	Localization of septin proteins in the mouse cochlea.	SEPTIN9 SEPTIN12	1.24e-04	16	36	2	22575789
Pubmed	SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling.	SCUBE1 SCUBE2	1.58e-04	18	36	2	33308444
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	MLLT6 KDM4A ZNF592 KDM4C ZNF710 ZNF2	1.66e-04	808	36	6	20412781
Pubmed	Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.	SCUBE1 KDM4C	1.76e-04	19	36	2	23149075
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KDM4A KDM4C	2.16e-04	21	36	2	27626377
Pubmed	Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration.	DYNC1I1 DYNC1I2	2.16e-04	21	36	2	30110642
Pubmed	Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin.	KDM4A KDM4C	2.38e-04	22	36	2	28963472
Pubmed	Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity.	DYNC1I1 DYNC1I2	2.60e-04	23	36	2	36973253
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	KDM4A KDM4C	5.39e-04	33	36	2	26864203
Pubmed	Differential impact of Lhx2 deficiency on expression of class I and class II odorant receptor genes in mouse.	OR52I1 OR52B2	5.39e-04	33	36	2	17350283
Pubmed	Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking.	SEPTIN9 EEF1A2	6.07e-04	35	36	2	22337587
Pubmed	Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.	SEPTIN9 DYNC1I2 EEF1A2	7.28e-04	170	36	3	16159877
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	GSPT2 SEPTIN9 DYNC1I2 GSPT1	7.52e-04	399	36	4	37536630
Pubmed	Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.	KDM4A KDM4C	9.59e-04	44	36	2	24183668
Interaction	SCUBE2 interactions	SCUBE1 SCUBE2	1.65e-05	4	34	2	int:SCUBE2
Interaction	SCUBE1 interactions	SCUBE1 SCUBE2	2.75e-05	5	34	2	int:SCUBE1
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	OR52E4 OR52I1 SCUBE2 MUC2 OR52B2	7.57e-05	564	36	5	chr11p15
Cytoband	11p15.4	OR52E4 OR52I1 OR52B2	5.23e-04	200	36	3	11p15.4
GeneFamily	Olfactory receptors, family 52	OR52E4 OR52I1 OR52B2	5.84e-05	49	28	3	165
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	PRDM9 ZFP69B ZNF229 ZNF592 ZNF674 ZNF710 ZNF2	8.63e-05	718	28	7	28
GeneFamily	Dyneins, cytoplasmic	DYNC1I1 DYNC1I2	1.79e-04	13	28	2	538
GeneFamily	Septins	SEPTIN9 SEPTIN12	1.79e-04	13	28	2	732
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM4A KDM4C	6.25e-04	24	28	2	485
GeneFamily	Tudor domain containing	KDM4A KDM4C	1.49e-03	37	28	2	780
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_TBC1D26\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEMA3D SCUBE1 ZNF229 F12	1.03e-05	169	36	4	6e132fdd73b3a9c702eccf5a1a620ec6384b556e
ToppCell	5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SEMA3D STAB2 SCUBE2 DYNC1I1	1.29e-05	179	36	4	9fd9b136ecbcbd4e4f0d5875ede98d8d48608afb
Computational	Neighborhood of RAN	DYNC1I2 GSPT1 USP33 ZNF710	9.30e-05	196	14	4	GCM_RAN
Computational	Neighborhood of NF2	DYNC1I2 GSPT1 USP33 ZNF710	4.89e-04	302	14	4	GCM_NF2
Computational	Neighborhood of PTK2	DYNC1I2 USP33 ZNF710	7.85e-04	145	14	3	GCM_PTK2
Computational	Neighborhood of BAG5	DYNC1I2 USP33	1.08e-03	38	14	2	GCM_BAG5
Computational	Neighborhood of GSPT1	DYNC1I2 GSPT1 USP33	1.22e-03	169	14	3	GCM_GSPT1
Computational	Neighborhood of MLL	DYNC1I2 GSPT1 USP33	1.33e-03	174	14	3	GCM_MLL
Drug	Pyridoxine hydrochloride [58-56-0]; Up 200; 19.4uM; PC3; HT_HG-U133A	PRDM9 STAB2 KDM4C ANGPT4 ZNF710	1.33e-05	195	36	5	5813_UP
Drug	Vincamine [1617-90-9]; Up 200; 11.2uM; HL60; HT_HG-U133A	KDM4C F12 GSPT1 ZNF710 EEF1A2	1.47e-05	199	36	5	2367_UP
Disease	alopecia areata (is_marker_for)	KDM4A KDM4C	5.77e-05	10	34	2	DOID:986 (is_marker_for)
Disease	respiratory symptom measurement, COVID-19	KDM4A SCUBE2 SEPTIN9	8.57e-05	74	34	3	EFO_0007939, MONDO_0100096
Disease	stem Cell Growth Factor beta measurement	STAB2 KDM4C F12	8.92e-05	75	34	3	EFO_0008292
Disease	stomach carcinoma (is_marker_for)	KDM4A KDM4C	3.50e-04	24	34	2	DOID:5517 (is_marker_for)
Disease	energy expenditure	KDM4C DYNC1I1	4.44e-04	27	34	2	EFO_0005109
Disease	factor VIII measurement	STAB2 F12	9.78e-04	40	34	2	EFO_0004630
Disease	response to fenofibrate	SCUBE1 KDM4C	1.52e-03	50	34	2	GO_1901557
Disease	melanoma	SAC3D1 KDM4A KDM4C	2.90e-03	248	34	3	C0025202
Disease	chemokine (C-C motif) ligand 27 measurement	KDM4C F12	2.96e-03	70	34	2	EFO_0008082
Disease	multisite chronic pain	OR52B2 DYNC1I1	5.38e-03	95	34	2	EFO_0010100
Disease	autism spectrum disorder, schizophrenia	KDM4A ZNF592 EEF1A2	6.26e-03	327	34	3	EFO_0003756, MONDO_0005090

Protein segments in the cluster

Peptide	Gene	Start	Entry
PLVYCDGHACSVAVH	MLLT6	21	P55198
VPQHRGHVCYLGVCR	ADM5	31	C9JUS6
CGVVSLHCFQHVVAV	ANKLE1	531	Q8NAG6
CGHNIVPHTYCEHRG	OR52E4	171	Q8NGH9
CIPIFESGVHSYVCH	CRB2	411	Q5IJ48
AAHTHPVYCVNVVGT	DYNC1I1	386	O14576
SAAAHTHPVYCVNVV	DYNC1I2	376	Q13409
CPGYNAVLHIHTCIE	GSPT2	536	Q8IYD1
CLTNIVPHSYCEHIG	OR52B2	171	Q96RD2
VPVSQCHCRLHGHLY	MUC2	346	Q02817
CSVRVHASCYGVPPA	KDM4A	741	O75164
CCVRVHASCYGIPSH	KDM4C	721	Q9H3R0
RPVCGRVSCHVTCYH	KRTAP4-16	131	G5E9R7
RVSCHVTCYHPTCVI	KRTAP4-16	136	G5E9R7
ICPGYNAVLHIHTCI	GSPT1	406	P15170
CYHQRTHTGEKPYVC	PRDM9	876	Q9NQV7
GYSPVIDCHTAHIAC	EEF1A2	356	Q05639
RGCETLVVQHGHCSY	ANGPT4	31	Q9Y264
GHHYNTTTHRCIRCP	SCUBE1	746	Q8IWY4
PGHFYNTTTHRCIRC	SCUBE2	756	Q9NQ36
YLPSCAVQCHVGHAR	SAC3D1	286	A6NKF1
CPSRYHCTHEAGVHS	NUP88	401	Q99567
PFCGSNVVVHSYCKH	OR52I1	171	Q8NGK6
EVEGHRLCHCPVGYT	F12	191	P00748
VRPLCCHYGAVVGLH	TAF6L	301	Q9Y6J9
EQGSVCTYHPGAVHC	SUSD2	336	Q9UGT4
CTYHPGAVHCVRSVQ	SUSD2	341	Q9UGT4
TRVHCCLYFIPATGH	SEPTIN9	406	Q9UHD8
THIYVCGTGAFHPIC	SEMA3D	141	O95025
QRIHTGESPYECHQC	ZNF2	276	Q9BSG1
KVGYRCIHCGVVHLT	ZNF592	796	Q92610
TRVHCCVYFVPPTGH	SEPTIN12	156	Q8IYM1
LIHTSVRPYQCHICF	ZNF710	511	Q8N1W2
HCTYLGPNRHSCTCQ	STAB2	251	Q8WWQ8
QTSACGPYVQFCHIH	STAB2	826	Q8WWQ8
THQRLHTGEKPYTCC	ZNF229	701	Q9UJW7
CQYVHPCVHVYVTVG	USP41	11	Q3LFD5
QRVHTGVKPYECSHC	ZFP69B	466	Q9UJL9
VHQRTHTGEKPYECC	ZNF674	241	Q2M3X9
GPAVNHLYICHTCQI	USP33	801	Q8TEY7