Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionalpha-tocopherol omega-hydroxylase activity

CYP4F2 CYP4F3 CYP4F11

6.64e-075823GO:0052871
GeneOntologyMolecularFunctionleukotriene-B4 20-monooxygenase activity

CYP4F2 CYP4F3 CYP4F11

2.31e-067823GO:0050051
GeneOntologyMolecularFunctionalkane 1-monooxygenase activity

CYP4F2 CYP4F3 CYP4F11

2.31e-067823GO:0018685
GeneOntologyMolecularFunctionarachidonate omega-hydroxylase activity

CYP4F2 CYP4F3 CYP4F11

7.85e-0610823GO:0052869
GeneOntologyMolecularFunctionfatty acid omega-hydroxylase activity

CYP4F2 CYP4F3 CYP4F11

7.85e-0610823GO:0120250
GeneOntologyMolecularFunctionlong-chain fatty acid omega-hydroxylase activity

CYP4F2 CYP4F3 CYP4F11

7.85e-0610823GO:0102033
GeneOntologyMolecularFunctioncholine-phosphate cytidylyltransferase activity

PCYT1A PCYT1B

1.67e-052822GO:0004105
GeneOntologyMolecularFunction20-hydroxy-leukotriene B4 omega oxidase activity

CYP4F2 CYP4F3

1.67e-052822GO:0097258
GeneOntologyMolecularFunction20-aldehyde-leukotriene B4 20-monooxygenase activity

CYP4F2 CYP4F3

1.67e-052822GO:0097259
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

CYP4F2 CYP4F3 CYP4F11

1.85e-0513823GO:0016713
GeneOntologyMolecularFunctionarachidonate epoxygenase activity

CYP4F2 CYP4F3 CYP4F11

1.27e-0424823GO:0008392
GeneOntologyMolecularFunctionarachidonate monooxygenase activity

CYP4F2 CYP4F3 CYP4F11

1.82e-0427823GO:0008391
GeneOntologyMolecularFunctionphosphatidylinositol-3,5-bisphosphate 5-phosphatase activity

PIKFYVE SYNJ1

2.47e-046822GO:0043813
GeneOntologyMolecularFunctioncentromeric DNA binding

MLH3 MSH2

3.45e-047822GO:0019237
GeneOntologyMolecularFunctionaromatase activity

CYP4F2 CYP4F3 CYP4F11

3.97e-0435823GO:0070330
GeneOntologyMolecularFunctionheme binding

NOX5 CYP4F22 CYP4F2 CYP4F3 CYP4F11

4.33e-04154825GO:0020037
GeneOntologyMolecularFunction3-hydroxyacyl-CoA dehydratase activity

HADHA HACD1

4.59e-048822GO:0018812
GeneOntologyMolecularFunctiontetrapyrrole binding

NOX5 CYP4F22 CYP4F2 CYP4F3 CYP4F11

5.76e-04164825GO:0046906
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

CYP4F2 CYP4F3 CYP4F11

5.91e-0440823GO:0016709
GeneOntologyMolecularFunctioniron ion binding

XDH CYP4F22 CYP4F2 CYP4F3 CYP4F11

6.09e-04166825GO:0005506
GeneOntologyMolecularFunctionDNA secondary structure binding

NEIL3 MSH2 FANCM

6.36e-0441823GO:0000217
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

MLH3 UNG NEIL3 MSH2 NME1 FANCM

7.33e-04262826GO:0140097
GeneOntologyMolecularFunctioncytidylyltransferase activity

PCYT1A PCYT1B

7.34e-0410822GO:0070567
GeneOntologyMolecularFunctionenoyl-CoA hydratase activity

HADHA HACD1

1.07e-0312822GO:0004300
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP4F2 CYP4F3 CYP4F11

1.07e-0349823GO:0016712
GeneOntologyMolecularFunctionphosphatidylinositol phosphate 5-phosphatase activity

PIKFYVE SYNJ1

1.26e-0313822GO:0034595
GeneOntologyMolecularFunctionmonooxygenase activity

CYP4F22 CYP4F2 CYP4F3 CYP4F11

1.29e-03115824GO:0004497
GeneOntologyMolecularFunctionmismatched DNA binding

MLH3 MSH2

1.47e-0314822GO:0030983
GeneOntologyMolecularFunctionDNA N-glycosylase activity

UNG NEIL3

1.47e-0314822GO:0019104
GeneOntologyMolecularFunctionarachidonate binding

CYP4F2 CYP4F11

1.69e-0315822GO:0050544
GeneOntologyMolecularFunctionphosphatidylinositol-3,5-bisphosphate phosphatase activity

PIKFYVE SYNJ1

1.93e-0316822GO:0106018
GeneOntologyMolecularFunctionicosanoid binding

CYP4F2 CYP4F11

1.93e-0316822GO:0050542
GeneOntologyMolecularFunctionicosatetraenoic acid binding

CYP4F2 CYP4F11

1.93e-0316822GO:0050543
GeneOntologyMolecularFunctionribosomal small subunit binding

UNG NME1

2.18e-0317822GO:0043024
GeneOntologyMolecularFunctionfour-way junction DNA binding

MSH2 FANCM

2.72e-0319822GO:0000400
GeneOntologyMolecularFunctionhydrolase activity, acting on glycosyl bonds

BPHL ACER3 UNG NEIL3

2.94e-03144824GO:0016798
GeneOntologyMolecularFunctionnuclear import signal receptor activity

IPO5 RANBP6

3.02e-0320822GO:0061608
GeneOntologyMolecularFunctionATP-dependent DNA damage sensor activity

MLH3 MSH2

3.02e-0320822GO:0140664
GeneOntologyMolecularFunctionmagnesium ion binding

MSH2 PGP NME1 OPA1 ADSS1

3.50e-03247825GO:0000287
GeneOntologyMolecularFunctionclathrin adaptor activity

AP1M2 AP1M1

3.65e-0322822GO:0035615
GeneOntologyMolecularFunctionDNA damage sensor activity

MLH3 MSH2

4.34e-0324822GO:0140612
GeneOntologyMolecularFunctioncarbon-oxygen lyase activity

NEIL3 HADHA HACD1

4.68e-0382823GO:0016835
GeneOntologyMolecularFunctioncargo adaptor activity

AP1M2 AP1M1

4.70e-0325822GO:0140312
GeneOntologyMolecularFunctiondamaged DNA binding

UNG NEIL3 MSH2

5.01e-0384823GO:0003684
GeneOntologyMolecularFunctionnuclear localization sequence binding

IPO5 RANBP6

5.47e-0327822GO:0008139
GeneOntologyMolecularFunctionphosphatidylinositol bisphosphate phosphatase activity

PIKFYVE SYNJ1

5.47e-0327822GO:0034593
GeneOntologyMolecularFunctionlong-chain fatty acid binding

CYP4F2 CYP4F11

5.88e-0328822GO:0036041
GeneOntologyMolecularFunctionphosphatidylinositol phosphate phosphatase activity

PIKFYVE SYNJ1

6.73e-0330822GO:0052866
GeneOntologyMolecularFunctionnucleocytoplasmic carrier activity

IPO5 RANBP6

7.63e-0332822GO:0140142
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

CYP4F22 CYP4F2 CYP4F3 CYP4F11

8.38e-03194824GO:0016705
GeneOntologyMolecularFunctionphosphatidylcholine binding

PCYT1A PCYT1B

8.58e-0334822GO:0031210
GeneOntologyBiologicalProcessleukotriene B4 catabolic process

CYP4F2 CYP4F3 CYP4F11

1.16e-066813GO:0036101
GeneOntologyBiologicalProcessleukotriene B4 metabolic process

CYP4F2 CYP4F3 CYP4F11

2.02e-067813GO:0036102
GeneOntologyBiologicalProcessleukotriene catabolic process

CYP4F2 CYP4F3 CYP4F11

3.22e-068813GO:0036100
GeneOntologyBiologicalProcessorganophosphate metabolic process

PIKFYVE PCYT1A TPST1 HK2 BPHL SYNJ1 PIGK XDH UNG HADHA PGP NME1 OPA1 HACD1 PCYT1B ADSS1

7.82e-0611428116GO:0019637
GeneOntologyBiologicalProcessicosanoid catabolic process

CYP4F2 CYP4F3 CYP4F11

9.41e-0611813GO:1901523
GeneOntologyBiologicalProcesslong-chain fatty acid catabolic process

CYP4F2 CYP4F3 CYP4F11

1.25e-0512813GO:0042758
GeneOntologyBiologicalProcessmenaquinone catabolic process

CYP4F2 CYP4F11

4.56e-053812GO:0042361
GeneOntologyBiologicalProcessfatty acid derivative catabolic process

CYP4F2 CYP4F3 CYP4F11

8.51e-0522813GO:1901569
GeneOntologyBiologicalProcessmenaquinone metabolic process

CYP4F2 CYP4F11

9.09e-054812GO:0009233
GeneOntologyBiologicalProcessphylloquinone metabolic process

CYP4F2 CYP4F11

9.09e-054812GO:0042374
GeneOntologyBiologicalProcessphylloquinone catabolic process

CYP4F2 CYP4F11

9.09e-054812GO:0042376
GeneOntologyBiologicalProcessvitamin K catabolic process

CYP4F2 CYP4F11

9.09e-054812GO:0042377
GeneOntologyBiologicalProcesspolyol metabolic process

EPHX1 ACER3 SYNJ1 DHFR PGP

1.24e-04123815GO:0019751
GeneOntologyBiologicalProcessdiol biosynthetic process

EPHX1 ACER3 DHFR

1.26e-0425813GO:0034312
GeneOntologyBiologicalProcessarachidonate metabolic process

EPHX1 CYP4F2 CYP4F3 CYP4F11

1.48e-0468814GO:0019369
GeneOntologyBiologicalProcesspolyol biosynthetic process

EPHX1 ACER3 DHFR PGP

1.57e-0469814GO:0046173
GeneOntologyBiologicalProcessprostaglandin catabolic process

CYP4F2 CYP4F11

2.26e-046812GO:1905344
GeneOntologyBiologicalProcessprostanoid catabolic process

CYP4F2 CYP4F11

2.26e-046812GO:0062232
GeneOntologyBiologicalProcessoxoacid metabolic process

EPHX1 TPST1 HK2 SGPL1 DHFR CYP4F22 CYP4F2 CYP4F3 HADHA GPT2 CYP4F11 HACD1 ADSS1

2.31e-0410588113GO:0043436
GeneOntologyBiologicalProcessicosanoid metabolic process

EPHX1 CYP4F22 CYP4F2 CYP4F3 CYP4F11

2.43e-04142815GO:0006690
GeneOntologyBiologicalProcessorganic acid metabolic process

EPHX1 TPST1 HK2 SGPL1 DHFR CYP4F22 CYP4F2 CYP4F3 HADHA GPT2 CYP4F11 HACD1 ADSS1

2.44e-0410648113GO:0006082
GeneOntologyBiologicalProcessglycerophospholipid metabolic process

PIKFYVE PCYT1A SYNJ1 PIGK HADHA PGP PCYT1B

2.64e-04320817GO:0006650
GeneOntologyBiologicalProcessglycerolipid metabolic process

PIKFYVE PCYT1A SYNJ1 PIGK HADHA PGP SERPINA12 PCYT1B

2.80e-04429818GO:0046486
GeneOntologyBiologicalProcessfatty acid derivative metabolic process

CYP4F2 CYP4F3 CYP4F11 HACD1

3.06e-0482814GO:1901568
GeneOntologyBiologicalProcessCDP-choline pathway

PCYT1A PCYT1B

3.16e-047812GO:0006657
GeneOntologyBiologicalProcesscementum mineralization

WLS HACD1

3.16e-047812GO:0071529
GeneOntologyBiologicalProcessdiol metabolic process

EPHX1 ACER3 DHFR

3.20e-0434813GO:0034311
GeneOntologyBiologicalProcesspositive regulation of cellular response to insulin stimulus

ESRRA OPA1 SERPINA12

4.46e-0438813GO:1900078
GeneOntologyBiologicalProcessleukotriene metabolic process

CYP4F2 CYP4F3 CYP4F11

5.59e-0441813GO:0006691
GeneOntologyBiologicalProcesscarboxylic acid metabolic process

EPHX1 HK2 SGPL1 DHFR CYP4F22 CYP4F2 CYP4F3 HADHA GPT2 CYP4F11 HACD1 ADSS1

6.89e-0410358112GO:0019752
GeneOntologyBiologicalProcesslipid catabolic process

ACER3 LIPM SGPL1 CYP4F2 CYP4F3 HADHA CYP4F11

7.59e-04382817GO:0016042
GeneOntologyBiologicalProcessvitamin K metabolic process

CYP4F2 CYP4F11

8.19e-0411812GO:0042373
GeneOntologyBiologicalProcesslactation

HK2 XDH NME1

8.88e-0448813GO:0007595
GeneOntologyBiologicalProcesspurine ribonucleotide metabolic process

TPST1 HK2 BPHL XDH NME1 OPA1 HACD1 ADSS1

8.98e-04512818GO:0009150
GeneOntologyBiologicalProcessorganic hydroxy compound metabolic process

EPHX1 ACER3 SYNJ1 DHFR CYP4F2 CYP4F3 PGP CYP4F11 SERPINA12

9.09e-04641819GO:1901615
GeneOntologyBiologicalProcessbase-excision repair, AP site formation

UNG NEIL3

9.80e-0412812GO:0006285
GeneOntologyBiologicalProcessfat-soluble vitamin catabolic process

CYP4F2 CYP4F11

9.80e-0412812GO:0042363
GeneOntologyCellularComponentMon1-Ccz1 complex

CCZ1B CCZ1

1.55e-045832GO:0035658
GeneOntologyCellularComponentendoplasmic reticulum membrane

EPHX1 PCYT1A ACER3 NOX5 PIGK OR5D18 SGPL1 CYP4F22 CYP4F2 CYP4F3 WLS CYP4F11 HACD1 PCYT1B

5.33e-0412938314GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

EPHX1 PCYT1A ACER3 NOX5 PIGK OR5D18 SGPL1 CYP4F22 CYP4F2 CYP4F3 WLS CYP4F11 HACD1 PCYT1B

5.58e-0412998314GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

EPHX1 PCYT1A ACER3 NOX5 PIGK OR5D18 SGPL1 CYP4F22 CYP4F2 CYP4F3 WLS CYP4F11 HACD1 PCYT1B

6.88e-0413278314GO:0042175
GeneOntologyCellularComponentmismatch repair complex

MLH3 MSH2

8.37e-0411832GO:0032300
GeneOntologyCellularComponentAP-1 adaptor complex

AP1M2 AP1M1

1.00e-0312832GO:0030121
DomainDUF1712

CCZ1B CCZ1

1.77e-052792PF08217
DomainDUF1712_fun

CCZ1B CCZ1

1.77e-052792IPR013176
DomainCyt_P450_E_grp-I

CYP4F22 CYP4F2 CYP4F3 CYP4F11

3.87e-0545794IPR002401
DomainCyt_P450_CS

CYP4F22 CYP4F2 CYP4F3 CYP4F11

7.42e-0553794IPR017972
DomainCYTOCHROME_P450

CYP4F22 CYP4F2 CYP4F3 CYP4F11

9.88e-0557794PS00086
Domain-

CYP4F22 CYP4F2 CYP4F3 CYP4F11

1.06e-04587941.10.630.10
Domainp450

CYP4F22 CYP4F2 CYP4F3 CYP4F11

1.06e-0458794PF00067
DomainCyt_P450

CYP4F22 CYP4F2 CYP4F3 CYP4F11

1.21e-0460794IPR001128
DomainClathrin_mu_CS

AP1M2 AP1M1

2.62e-046792IPR018240
DomainCLAT_ADAPTOR_M_1

AP1M2 AP1M1

2.62e-046792PS00990
DomainCLAT_ADAPTOR_M_2

AP1M2 AP1M1

2.62e-046792PS00991
DomainAbhydrolase_1

EPHX1 BPHL LIPM

3.01e-0431793PF00561
DomainAB_hydrolase_1

EPHX1 BPHL LIPM

3.63e-0433793IPR000073
DomainCyt_trans-like

PCYT1A PCYT1B

3.66e-047792IPR004821
DomainCTP_transf_like

PCYT1A PCYT1B

3.66e-047792PF01467
DomainClathrin_mu

AP1M2 AP1M1

7.78e-0410792IPR001392
DomainAdap_comp_sub

AP1M2 AP1M1

9.48e-0411792PF00928
DomainMHD

AP1M2 AP1M1

1.34e-0313792PS51072
DomainMHD

AP1M2 AP1M1

1.34e-0313792IPR028565
Domain-

EPHX1 BPHL CES5A LIPM

1.63e-031197943.40.50.1820
DomainAB_hydrolase

EPHX1 BPHL CES5A LIPM

1.63e-03119794IPR029058
DomainAP_mu_sigma_su

AP1M2 AP1M1

2.04e-0316792IPR022775
DomainClat_adaptor_s

AP1M2 AP1M1

2.04e-0316792PF01217
DomainLIPASE_SER

BPHL LIPM

5.38e-0326792PS00120
DomainLongin-like_dom

AP1M2 AP1M1

6.22e-0328792IPR011012
PathwayREACTOME_EICOSANOIDS

CYP4F22 CYP4F2 CYP4F3 CYP4F11

2.11e-0712664M27129
PathwayREACTOME_MISCELLANEOUS_SUBSTRATES

CYP4F22 CYP4F2 CYP4F3 CYP4F11

2.11e-0712664M27128
PathwayREACTOME_EICOSANOIDS

CYP4F22 CYP4F2 CYP4F3 CYP4F11

2.11e-0712664MM14845
PathwayREACTOME_FATTY_ACIDS

CYP4F22 CYP4F2 CYP4F3 CYP4F11

5.75e-0715664M27126
PathwayREACTOME_MISCELLANEOUS_SUBSTRATES

CYP4F22 CYP4F2 CYP4F3 CYP4F11

1.28e-0618664MM14843
PathwayREACTOME_FATTY_ACIDS

CYP4F22 CYP4F2 CYP4F3 CYP4F11

1.28e-0618664MM14841
PathwayREACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX

CYP4F22 CYP4F2 CYP4F3 CYP4F11

2.47e-0621664M27137
PathwayREACTOME_METABOLISM_OF_LIPIDS

PIKFYVE HDAC3 PCYT1A ACER3 SYNJ1 SGPL1 CYP4F22 CYP4F2 CYP4F3 HADHA CYP4F11 HACD1 PCYT1B

4.84e-066206613MM15193
PathwayREACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX

CYP4F22 CYP4F2 CYP4F3 CYP4F11

5.15e-0625664MM14858
PathwayREACTOME_METABOLISM_OF_LIPIDS

PIKFYVE HDAC3 PCYT1A ACER3 SYNJ1 SGPL1 ESRRA CYP4F22 CYP4F2 CYP4F3 HADHA CYP4F11 HACD1 PCYT1B

8.39e-067576614M27451
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

EPHX1 BPHL CYP4F22 CYP4F2 CYP4F3 CYP4F11

8.85e-06104666M738
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

EPHX1 BPHL CYP4F22 CYP4F2 CYP4F3 CYP4F11

9.35e-06105666MM14842
PathwayWP_KENNEDY_PATHWAY_FROM_SPHINGOLIPIDS

PCYT1A SGPL1 PCYT1B

3.44e-0514663M39620
PathwayWP_KENNEDY_PATHWAY

PCYT1A SGPL1 PCYT1B

3.44e-0514663MM15980
PathwayWP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES

CYP4F2 CYP4F3 CYP4F11

3.44e-0514663MM15842
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

EPHX1 TPST1 BPHL CYP4F22 CYP4F2 CYP4F3 CYP4F11

7.10e-05219667MM14838
PathwayREACTOME_BIOLOGICAL_OXIDATIONS

EPHX1 TPST1 BPHL CYP4F22 CYP4F2 CYP4F3 CYP4F11

7.31e-05220667M10320
PathwayREACTOME_FATTY_ACID_METABOLISM

CYP4F22 CYP4F2 CYP4F3 HADHA CYP4F11 HACD1

1.41e-04170666MM15573
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

CYP4F22 CYP4F2 CYP4F3 CYP4F11

1.64e-0459664M27140
PathwayREACTOME_FATTY_ACID_METABOLISM

CYP4F22 CYP4F2 CYP4F3 HADHA CYP4F11 HACD1

1.70e-04176666M27854
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

CYP4F22 CYP4F2 CYP4F3 CYP4F11

1.87e-0461664MM14861
PathwayWP_OXIDATION_BY_CYTOCHROME_P450

CYP4F22 CYP4F2 CYP4F3 CYP4F11

1.99e-0462664M39653
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP4F22 CYP4F2 CYP4F3 CYP4F11

2.25e-0464664M5650
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP4F22 CYP4F2 CYP4F3 CYP4F11

2.54e-0466664MM14839
PathwayWP_EICOSANOID_METABOLISM_VIA_CYCLOOXYGENASES_COX

CYP4F2 CYP4F3 CYP4F11

4.84e-0433663MM15918
PathwayWP_EICOSANOID_METABOLISM_VIA_LIPOXYGENASES_LOX

CYP4F2 CYP4F3 CYP4F11

4.84e-0433663MM15963
PathwayREACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION

AP1M2 AP1M1

9.48e-0410662M17019
PathwayREACTOME_SYNTHESIS_OF_16_20_HYDROXYEICOSATETRAENOIC_ACIDS_HETE

CYP4F2 CYP4F11

1.16e-0311662MM14863
PathwayREACTOME_SPHINGOLIPID_CATABOLISM

ACER3 SGPL1

1.38e-0312662M48264
PathwayREACTOME_SPHINGOLIPID_CATABOLISM

ACER3 SGPL1

1.38e-0312662MM17238
PathwayWP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II

EPHX1 CYP4F22 CYP4F2 CYP4F3 CYP4F11

1.64e-03183665M39588
PathwayWP_ONECARBON_METABOLISM_AND_RELATED_PATHWAYS

PCYT1A DHFR PCYT1B

2.05e-0354663MM15848
PathwayBIOCARTA_NDKDYNAMIN_PATHWAY

SYNJ1 NME1

2.18e-0315662MM1387
PathwayREACTOME_PHOSPHOLIPID_METABOLISM

PIKFYVE PCYT1A SYNJ1 HADHA PCYT1B

2.22e-03196665MM14591
PathwayWP_DNA_REPAIR_PATHWAYS_FULL_NETWORK

UNG NEIL3 MSH2 FANCM

2.40e-03120664M40049
Pubmed

Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.

CYP4F2 CYP4F3 CYP4F11

5.63e-08485318065749
Pubmed

The cytochrome P450 4 (CYP4) family.

CYP4F2 CYP4F3 CYP4F11

2.80e-0768539068972
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

IPO5 PCYT1A HK2 UBE2N TSR1 PUF60 PPIL3 AP1M1 MSH2 HADHA PGP NME1 DCTN1 PALLD OPA1

1.59e-061415851528515276
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

IPO5 HK2 TSR1 PUF60 AP1M1 MSH2 HADHA PALLD OPA1 CNN3

4.49e-06653851033742100
Pubmed

Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.

IPO5 EPHX1 PCYT1A PIGK SGPL1 FKBP4

4.53e-0617485632149426
Pubmed

Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11.

CYP4F2 CYP4F11

5.90e-06285224138531
Pubmed

Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant.

PCYT1A PCYT1B

5.90e-06285210480912
Pubmed

Cloning and expression of a novel form of leukotriene B4 omega-hydroxylase from human liver.

CYP4F2 CYP4F3

5.90e-0628528026587
Pubmed

The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs.

UNG MSH2

5.90e-06285219596785
Pubmed

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation.

UNG MSH2

5.90e-06285215494304
Pubmed

Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids.

CYP4F3 CYP4F11

5.90e-06285215364545
Pubmed

Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network.

AP1M2 AP1M1

5.90e-0628528810314
Pubmed

Tissue and zonal-specific expression of an olfactory receptor transgene.

OR10H3 OR10H4

5.90e-0628529412503
Pubmed

Differential dephosphorylation of CTP:phosphocholine cytidylyltransferase upon translocation to nuclear membranes and lipid droplets.

PCYT1A PCYT1B

5.90e-06285232186954
Pubmed

Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells.

AP1M2 AP1M1

5.90e-06285210338135
Pubmed

CTP:phosphocholine cytidylyltransferase: Function, regulation, and structure of an amphitropic enzyme required for membrane biogenesis.

PCYT1A PCYT1B

5.90e-06285226165797
Pubmed

Gene structure, expression and identification of a new CTP:phosphocholine cytidylyltransferase beta isoform.

PCYT1A PCYT1B

5.90e-06285212842190
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

EPHX1 HK2 UBE2N SGPL1 DHFR MSH2 HADHA PGP PALLD

6.49e-0653485935032548
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

IPO5 HDAC3 UBE2N TSR1 PUF60 MSH2 HADHA NME1 GPT2 DCTN1 OPA1 FKBP4 ADSS1

1.02e-051247851327684187
Pubmed

Global landscape of HIV-human protein complexes.

HDAC3 SGPL1 RANBP6 AP1M1 UNG MSH2 HADHA FKBP4

1.66e-0545785822190034
Pubmed

DSB structure impacts DNA recombination leading to class switching and chromosomal translocations in human B cells.

UNG MSH2

1.77e-05385230946744
Pubmed

PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.

CCZ1B CCZ1

1.77e-05385232160108
Pubmed

AID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B-cell lymphoma.

UNG MSH2

1.77e-05385226385350
Pubmed

Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides.

CYP4F2 CYP4F3

1.77e-05385215145985
Pubmed

The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice.

UNG MSH2

1.77e-05385216894013
Pubmed

AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells.

UNG MSH2

1.77e-05385222768095
Pubmed

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair.

UNG MSH2

1.77e-05385216407970
Pubmed

AID Phosphorylation Regulates Mismatch Repair-Dependent Class Switch Recombination and Affinity Maturation.

UNG MSH2

1.77e-05385231757865
Pubmed

Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions.

UNG MSH2

1.77e-05385221151102
Pubmed

Distribution and function of AP-1 clathrin adaptor complexes in polarized epithelial cells.

AP1M2 AP1M1

1.77e-05385211157985
Pubmed

ALDH2 attenuates myocardial pyroptosis through breaking down Mitochondrion-NLRP3 inflammasome pathway in septic shock.

HDAC3 HADHA

1.77e-05385236992838
Pubmed

Hexokinase 2 and nuclear factor erythroid 2-related factor 2 transcriptionally coactivate xanthine oxidoreductase expression in stressed glioma cells.

HK2 XDH

1.77e-05385229414774
Pubmed

Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.

UNG MSH2

1.77e-05385217090531
Pubmed

Two levels of protection for the B cell genome during somatic hypermutation.

UNG MSH2

1.77e-05385218273020
Pubmed

Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.

UNG MSH2

1.77e-05385222447450
Pubmed

Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination.

UNG MSH2

1.77e-05385223140944
Pubmed

MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta.

MLH3 MSH2

1.77e-05385220154325
Pubmed

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.

UNG MSH2

1.77e-05385228775312
Pubmed

Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.

HK2 MSH2 HADHA DCTN1 PALLD CNN3

2.50e-0523585628378594
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

IPO5 UBE2N PUF60 PWP2 AP1M1 MSH2 HADHA DCTN1 FKBP4

2.65e-0563885933239621
Pubmed

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.

CYP4F22 CYP4F2 CYP4F3 CYP4F11

2.69e-057085415128046
Pubmed

Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge.

HDAC3 ESRRA

3.53e-05485228614293
Pubmed

CK2 and GAK/auxilin2 are major protein kinases in clathrin-coated vesicles.

AP1M2 AP1M1

3.53e-05485212010461
Pubmed

Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation.

AP1M2 AP1M1

3.53e-05485210887964
Pubmed

Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism.

CYP4F2 CYP4F11

3.53e-05485222665481
Pubmed

Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation.

UNG MSH2

3.53e-05485219901081
Pubmed

Early embryonic lethality in mice with targeted deletion of the CTP:phosphocholine cytidylyltransferase alpha gene (Pcyt1a).

PCYT1A PCYT1B

3.53e-05485215798219
Pubmed

Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14.

CYP4F2 CYP4F11

3.53e-05485211185557
Pubmed

AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected].

UNG MSH2

3.53e-05485221804017
Pubmed

AID and caspase 8 shape the germinal center response through apoptosis.

UNG MSH2

3.53e-05485224244021
Pubmed

Impact of genetic factors (VKORC1, CYP2C9, CYP4F2 and EPHX1) on the anticoagulation response to fluindione.

EPHX1 CYP4F2

3.53e-05485221883387
Pubmed

Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta.

HDAC3 GTF2IRD1

3.53e-05485212239342
Pubmed

Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells.

CCZ1B CCZ1

3.53e-05485220305638
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

IPO5 CCZ1B HK2 CCZ1 DHFR AP1M1 MSH2 HADHA NME1 WLS DCTN1 OPA1

5.44e-051257851237317656
Pubmed

Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism.

CYP4F2 CYP4F11

5.87e-05585222969154
Pubmed

Genomic structure and chromosome mapping of the genes encoding clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B (Ap1m2).

AP1M2 AP1M1

5.87e-05585210640811
Pubmed

Human MutS and FANCM complexes function as redundant DNA damage sensors in the Fanconi Anemia pathway.

MSH2 FANCM

5.87e-05585221975120
Pubmed

Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation.

CYP4F2 CYP4F11

5.87e-05585221466787
Pubmed

Interaction of tyrosine-based sorting signals with clathrin-associated proteins.

AP1M2 AP1M1

5.87e-0558527569928
Pubmed

A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells.

AP1M2 AP1M1

5.87e-05585210535737
Pubmed

Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.

CYP4F2 CYP4F3

5.87e-05585218577768
Pubmed

Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.

EPHX1 MLH3 ESRRA DHFR MSH2

6.29e-0517085519064572
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

IPO5 PCYT1A SGPL1 PWP2 AP1M1 HADHA OPA1 CNN3

6.98e-0556085835241646
Pubmed

Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors.

HDAC3 GTF2IRD1

8.80e-05685216055724
Pubmed

A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination.

UNG MSH2

8.80e-05685224097111
Pubmed

FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation.

UNG MSH2

8.80e-05685234819670
Pubmed

EHD2 interacts with the insulin-responsive glucose transporter (GLUT4) in rat adipocytes and may participate in insulin-induced GLUT4 recruitment.

AP1M2 AP1M1

8.80e-05685215182197
Pubmed

The DNA sequence of human chromosome 7.

CCZ1B TPST1 SAMD9 CCZ1 ERVFC1-1 GTF2IRD1 CALN1

1.06e-0444185712853948
Pubmed

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.

EPHX1 RASIP1 CCZ1B UBE2N AP1M1 HADHA GTF2IRD1 MTERF4

1.18e-0460485838803224
Pubmed

Common germline variation in mismatch repair genes and survival after a diagnosis of colorectal cancer.

MLH3 MSH2

1.23e-04785219115210
Pubmed

Mismatch repair gene polymorphisms and survival in invasive ovarian cancer patients.

MLH3 MSH2

1.23e-04785218723338
Pubmed

Common variants in mismatch repair genes and risk of invasive ovarian cancer.

MLH3 MSH2

1.23e-04785216774946
Pubmed

Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair.

UNG MSH2

1.23e-04785217947680
Pubmed

Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication.

UNG NEIL3

1.23e-04785228575236
Pubmed

Common variants in mismatch repair genes and risk of colorectal cancer.

MLH3 MSH2

1.23e-04785218364438
Pubmed

Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice.

CYP4F2 CYP4F11

1.23e-04785222160543
Pubmed

VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.

IPO5 EPHX1 HADHA NME1 PALLD FKBP4

1.60e-0432985635562734
Pubmed

Genetic factors (VKORC1, CYP2C9, EPHX1, and CYP4F2) are predictor variables for warfarin response in very elderly, frail inpatients.

EPHX1 CYP4F2

1.64e-04885219794411
Pubmed

Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I.

MLH3 MSH2

1.64e-04885216260499
Pubmed

A protein interaction landscape of breast cancer.

IPO5 HK2 UBE2N SGPL1 AP1M1 MSH2 HADHA FKBP4

1.64e-0463485834591612
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

IPO5 EPHX1 HK2 TSR1 PUF60 PWP2 AP1M1 MSH2 HADHA DCTN1 OPA1 FKBP4

1.77e-041425851230948266
Pubmed

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.

IPO5 TSR1 PPIL3 PWP2 UNG MSH2

1.88e-0433985630415952
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

SAMD9 HK2 TSR1 SGPL1 AP1M1 WLS GARRE1 PALLD

1.94e-0465085838777146
Pubmed

RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.

HDAC3 AP1M2 AP1M1 HADHA DCTN1 OPA1

2.03e-0434485636282215
Pubmed

Histone deacetylase 10 regulates DNA mismatch repair and may involve the deacetylation of MutS homolog 2.

HDAC3 MSH2

2.10e-04985226221039
Pubmed

The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter].

AP1M2 AP1M1

2.10e-04985211222723
Pubmed

Doublecortin interacts with mu subunits of clathrin adaptor complexes in the developing nervous system.

AP1M2 AP1M1

2.10e-04985211591131
Pubmed

New insights on the functional role of URG7 in the cellular response to ER stress.

IPO5 UBE2N HADHA

2.11e-044785329704455
Pubmed

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

SPATA7 EPHX1 BPHL UBE2N PUF60 AP1M1 HADHA DNAH8 FKBP4

2.53e-0485985931536960
Pubmed

GGAs: roles of the different domains and comparison with AP-1 and clathrin.

AP1M2 AP1M1

2.62e-041085211694590
Pubmed

High-resolution genetic, physical, and transcript map of the mnd2 region of mouse chromosome 6.

HK2 DCTN1

2.62e-04108529806835
Pubmed

WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis.

UNG NEIL3

2.62e-041085236546838
Pubmed

HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail.

AP1M2 AP1M1

2.62e-041085215569716
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

HDAC3 HK2 TSR1 PWP2 SP110 CNN3

3.00e-0437085622922362
Pubmed

Interactome Analysis Reveals a Novel Role for RAD6 in the Regulation of Proteasome Activity and Localization in Response to DNA Damage.

TSR1 PUF60 AP1M1 DCTN1

3.07e-0413185428031328
Pubmed

Comprehensive analysis of DNA repair gene variants and risk of meningioma.

UNG NEIL3 MSH2

3.75e-045785318270339
Pubmed

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.

HK2 SYNJ1 UBE2N NME1 DCTN1 FKBP4 CNN3

4.14e-0455285736293380
Pubmed

Parkinson's disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes.

UBE2N PUF60 NME1 OPA1 FKBP4

4.29e-0425785531046837
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

PUF60 PGP NME1 PALLD FKBP4 CNN3

4.48e-0439985635987950
Pubmed

Genetic determinants of warfarin dosing in the Han-Chinese population.

EPHX1 CYP4F2

4.52e-041385219958090
Cytoband19p13.12

CYP4F22 AP1M1 OR10H4 CYP4F2

2.36e-065085419p13.12
CytobandEnsembl 112 genes in cytogenetic band chr19p13

OR10H3 AP1M2 CYP4F22 AP1M1 OR10H4 CYP4F2 CYP4F3 CYP4F11

1.18e-04797858chr19p13
Cytoband2p13

HK2 DCTN1

8.36e-04238522p13
GeneFamilyCytochrome P450 family 4

CYP4F22 CYP4F2 CYP4F3 CYP4F11

3.35e-06365241003
GeneFamilyDNA glycosylases

UNG NEIL3

4.39e-04115221024
CoexpressionNFE2L2.V2

EPHX1 OR10H3 UBE2N DHFR NEIL3 CYP4F2 CYP4F3 GPT2 DNAH8 CYP4F11 PALLD SERPINA12

2.17e-084698112M2870
CoexpressionGSE11961_UNSTIM_VS_ANTI_IGM_AND_CD40_STIM_6H_FOLLICULAR_BCELL_DN

EPHX1 MLH3 BPHL CHST15 WLS FKBP4 ARID5A

2.92e-06200817M9335
CoexpressionGSE1925_CTRL_VS_IFNG_PRIMED_MACROPHAGE_24H_IFNG_STIM_UP

EPHX1 BPHL PIGK UNG NME1 CNN3

3.69e-05200816M6307
CoexpressionGSE5679_CTRL_VS_RARA_AGONIST_AM580_TREATED_DC_UP

TPST1 HK2 TSR1 DHFR NEIL3 NME1

3.69e-05200816M6555
CoexpressionGSE5679_CTRL_VS_PPARG_LIGAND_ROSIGLITAZONE_TREATED_DC_UP

IPO5 HK2 TSR1 PPIL3 NME1 FANCM

3.69e-05200816M6553
ToppCell10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-MEP|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

NME1 DNAH8 CYP4F11 HACD1 FKBP4 CALN1 PCYT1B

5.30e-08181847ee207ea171e2ffc22a7f850be57bb118a87e0f81
ToppCellPBMC-Control-cDC_1|Control / Compartment, Disease Groups and Clusters

SAMD9 NOX5 CD163L1 WLS SP110 CNN3

5.13e-071568469b6c5bcac516a62bcc1f5be32ffa8c92735ef0bc
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-Sox9_Epi-Sox9_Epi_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DHFR AP1M2 UNG MSH2 WLS FKBP4

1.88e-061958465276e874615823bb00e20ff160692e0946d7d400
ToppCellMegakaryocytic-erythropoietic-Erythro-cells-Basophilic_Erythroblast|Megakaryocytic-erythropoietic / Lineage, cell class and subclass

IPO5 UBE2N UNG NME1 HACD1 FKBP4

2.12e-061998466f159c1215439ec22374903124085746fa8da333
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

OOSP1 LIPM UNG NME1 SP110

9.62e-06150845cc8361bdcaa16ab6a0d6a3684690d709bc42ff3b
ToppCell10x5'v1-week_12-13-Hematopoietic-HSC/MPP_and_pro-MEP|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

CYP4F11 HACD1 FKBP4 CALN1 PCYT1B

1.48e-0516484547355439e578d1b1a387fb4ee761162028abea4a
ToppCelldroplet-Spleen-SPLEEN-30m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HK2 ACER3 XDH HACD1 ADSS1

2.20e-05178845be8af4d85b8835a85a168639c37857dcaa6b00bf
ToppCell368C-Lymphocytic-ILC-ILC-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

EPHX1 RASIP1 MLH3 ZNF341 TIGD1

2.32e-05180845eb5a57604c7f2ad256c300085dbf5069d0ae1ad0
ToppCell368C-Lymphocytic-ILC|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

EPHX1 RASIP1 MLH3 ZNF341 TIGD1

2.32e-05180845ddba4dc3bbcfe4e4a22400be73bbc62d3ff27d3c
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TOPAZ1 DHFR UNG NEIL3 ITGAD

2.51e-0518384542dc31d587fbb9724b2f0be5ee8ed77233f67b86
ToppCelldroplet-Spleen-nan-24m-Lymphocytic-plasma_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASIP1 TPST1 OOSP1 GPT2 ADSS1

3.00e-05190845992539c380576bf810c00a5f926cf1ee7d57dcf5
ToppCellmyeloid-CD34+_Myeloblast|myeloid / Lineage and Cell class

UNG NME1 HACD1 FKBP4 CALN1

3.32e-0519484535549e63e8c167e6c4bd76e2d7863d95a3f3c3d5
ToppCelldroplet-Lung-1m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHX1 RASIP1 CLIC5 DNAH8 GARRE1

3.32e-051948451ac52b00ea0b0ddbd04f5d85fa8c086980a78926
ToppCelldroplet-Lung-LUNG-1m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RASIP1 CLIC5 DNAH8 GARRE1 CNN3

3.32e-05194845f6c9cc362ccdbc7e790f7c8d1c56cab3557c5306
ToppCellhematopoetic_progenitors-CD34+_MPP|World / Lineage and Cell class

UNG NME1 HACD1 FKBP4 CALN1

3.40e-05195845851064ca1ab727b4972ad4b72234ee130998a799
ToppCellNS-critical-d_07-13|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

EPHX1 CYP4F3 WLS PALLD CNN3

3.65e-05198845a6e11c87b31beffb6af190c64b4ef3ee1d9dab8d
ToppCellControl_saline-Endothelial-Endothelial-Activated_Gen_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

RASIP1 SAMD9 CHST15 GARRE1 ARID5A

3.65e-051988453c3a5d2555f6af4aa33f9ea778808315d0e39d86
ToppCellImmune_cells-large_pre-B.|Immune_cells / Lineage and Cell class

IPO5 DHFR MSH2 FKBP4 CNN3

3.65e-05198845bc9ceefadb153907d2854d1f736d17349003cb31
ToppCellCV-Moderate-2|CV / Virus stimulation, Condition and Cluster

UBE2N DHFR UNG NME1 FKBP4

3.74e-051998452d98424a5247e87f98095c11fb945289092a9d75
ToppCellcontrol-unassigned|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SPATA7 ZNF717 ZNF341 AP1M1 GARRE1

3.74e-0519984550e2da35edff1aadef939cfbd4549f73c1a07717
DrugNADP(H

EPHX1 HK2 NOX5 DHFR XDH CYP4F22 UNG CYP4F2 CYP4F3 HADHA CYP4F11

3.30e-065278311CID000000930
DiseaseColorectal cancer, hereditary nonpolyposis, type 1

EPHX1 MLH3 MSH2

1.61e-0519773C2936783
DiseaseHereditary Nonpolyposis Colorectal Neoplasms

EPHX1 MLH3 MSH2

4.25e-0526773C0009405
DiseaseHereditary non-polyposis colorectal cancer syndrome

EPHX1 MLH3 MSH2

4.78e-0527773C1112155
DiseaseHereditary Nonpolyposis Colorectal Cancer

EPHX1 MLH3 MSH2

5.95e-0529773C1333990
Diseaseoctadecenedioylcarnitine (C18:1-DC) measurement

OR10H4 CYP4F2

6.69e-055772EFO_0800370
Diseaseoctadecenedioate (C18:1-DC) measurement

OR10H4 CYP4F2

6.69e-055772EFO_0800563
Diseasecancer (implicated_via_orthology)

IPO5 ESRRA DHFR RANBP6 MSH2 HACD1

7.34e-05268776DOID:162 (implicated_via_orthology)
Diseaseoctadecanedioylcarnitine (C18-DC) measurement

OR10H4 CYP4F2

1.40e-047772EFO_0800371
DiseaseLynch Syndrome

MLH3 MSH2

2.39e-049772C4552100
Diseasehexadecenedioate (C16:1-DC) measurement

CYP4F2 CYP4F11

2.39e-049772EFO_0800562
Diseaseoctadecanedioate measurement

OR10H4 CYP4F2

2.98e-0410772EFO_0021056
Diseasehypertension (biomarker_via_orthology)

HK2 XDH CYP4F2 CYP4F11 OPA1

3.25e-04227775DOID:10763 (biomarker_via_orthology)
Diseaseclonal hematopoiesis mutation measurement

COP1 OR10H4 MSH2

4.07e-0455773EFO_0020949
DiseaseHermansky-Pudlak syndrome (implicated_via_orthology)

CCZ1B CCZ1

5.99e-0414772DOID:3753 (implicated_via_orthology)
DiseaseColorectal Neoplasms

MLH3 DHFR UNG MSH2 NME1

8.01e-04277775C0009404
Diseaseurinary bladder cancer (is_implicated_in)

EPHX1 XDH MSH2

1.05e-0376773DOID:11054 (is_implicated_in)
DiseaseHereditary Non-Polyposis Colon Cancer Type 2

EPHX1 MLH3

1.12e-0319772C1333991
Diseaselaryngeal squamous cell carcinoma (is_marker_for)

XDH MSH2

1.12e-0319772DOID:2876 (is_marker_for)
DiseaseLeber Congenital Amaurosis

SPATA7 PCYT1A

1.50e-0322772C0339527
Diseaseprostate carcinoma (is_marker_for)

HDAC3 NME1

1.64e-0323772DOID:10286 (is_marker_for)
DiseaseLynch syndrome (is_implicated_in)

MLH3 MSH2

1.79e-0324772DOID:3883 (is_implicated_in)
DiseasePancytopenia

DHFR FANCM

2.10e-0326772C0030312

Protein segments in the cluster

PeptideGeneStartEntry
HLSGEFGKPYFIKLM

UNG

101

P13051
FGKPYFIKLMGFVAE

UNG

106

P13051
KTFAYHKDMPLIFIG

TPST1

61

O60507
FMTKIYHPNVDKLGR

UBE2N

71

P61088
CRFHSFKKVLYEMGP

GPT2

311

Q8TD30
PIMVFKGHRKAVSYA

COP1

591

Q8NHY2
YLKVKEPIFHQVMYG

ACER3

136

Q9NUN7
KTDFIKLFPRYIEMH

ADAM5

141

Q6NVV9
FLVSLYKFMKERHTP

ARID5A

61

Q03989
KSFPGGKEYLMRAHF

AP1M2

346

Q9Y6Q5
VYKKVGSLYPEMSAH

DCTN1

681

Q14203
KSFPGGKEYLMRAHF

AP1M1

346

Q9BXS5
KPLHVFGMTYFKEAS

CD163L1

521

Q9NR16
EKMPFHHVTAGLLYK

CALN1

41

Q9BXU9
KEGAHMNPEIYLFVK

CLIC5

166

Q9NZA1
LLGLGEHFLFMYKDP

RASIP1

476

Q5U651
HGSPMDKLKFLFQVY

NOX5

91

Q96PH1
IKINPKFHTPMYFFL

OR5D14

51

Q8NGL3
KINPKLHTPMYFFLS

OR5D18

51

Q8NGL1
KDYFPMIFGKAHEFI

MAGEC3

491

Q8TD91
KELFMYFGPKALRIH

NEIL3

81

Q8TAT5
IKMYFALAPIATVKH

LIPM

206

Q5VYY2
YEHKTFMYPVAKIRI

ERVFC1-1

201

P60608
KLHKMFITHGVYEPE

FANCM

636

Q8IYD8
DGTLYKLHPHFAKVM

HK2

861

P52789
VYKHIKEAGMFAPTQ

PCYT1A

181

P49585
VYKHIKEAGMFVPTQ

PCYT1B

181

Q9Y5K3
KIHNILYPYRFTKGM

MLH3

1171

Q9UHC1
GFDPHFSYMKLTKAL

PGP

171

A6NDG6
HMLKVHYPKFGVSED

CES5A

106

Q6NT32
KMLPTPSKFHYIFNL

DNAH8

2646

Q96JB1
MGLKVFTNLHYRKPE

OVOS2

656

Q6IE36
LMVPLLKFYFHDGVR

IPO5

706

O00410
ALIIMVFFKTYGIKH

PIGK

376

Q92643
VLHYGLYKKMIVFKP

HDAC3

36

O15379
MKTILGFKGLFYLHS

OOSP1

1

A8MZH6
VMHYSFASLIYLKPK

OR10H3

251

O60404
FASFIYLKPKGLHSM

OR10H4

256

Q8NGA5
GFFKRHYKEMLEDKP

ITGAD

1126

Q13349
PFFEMKLKHYKIFEG

PALLD

1001

Q8WX93
KLKHYKIFEGMPVTF

PALLD

1006

Q8WX93
IEGKLFPMKALGYFA

OPA1

486

O60313
FPMKALGYFAVVTGK

OPA1

491

O60313
KPHLGTCHKFYMQIF

PIKFYVE

801

Q9Y2I7
KHERMKVYVPTGFSA

EPHX1

386

P07099
HFLFMYDPKKRATAG

CDK10

301

Q15131
LTPAFHFNILKPYMK

CYP4F11

151

Q9HBI6
VYKEAMNHPGHLKLF

DHFR

121

P00374
IYAALPHVKKTGMFS

HACD1

221

B0YJ81
YAMKAGFHLNPKAIE

GARRE1

296

O15063
GGISFFPLDKMTYLK

CCZ1

191

P86791
GGISFFPLDKMTYLK

CCZ1B

191

P86790
LTPAFHFNILKPYMK

CYP4F2

151

P78329
AVSKRPEKVIGMHYF

HADHA

486

P40939
LTPAFHFNILKPYMK

CYP4F3

151

Q08477
LKTVKAHDGPVFAMY

EML6

896

Q6ZMW3
MEKGEHSIVYLKPSY

FKBP4

211

Q02790
YSKFLMHPEELFVVG

GTF2IRD1

591

Q9UHL9
LIAAAKYPSYIHKMV

BPHL

146

Q86WA6
LAHFYGVKLEGKVPM

ESRRA

396

P11474
YFEKDKQMFHIITGP

MSH2

656

P43246
PAFHFDILKPYMKIF

CYP4F22

161

Q6NT55
FYMFHVELTELGPKL

MFSD14B

401

Q5SR56
GLTDHPYQKIVLFFM

OR5G3

16

P0C626
VYFMYEALHGPPKKI

ADSS1

236

Q8N142
TMKHKGFAFVEYEVP

PUF60

166

Q9UHX1
MAFSKGFRIYHKLDP

SYNJ1

1

O43426
KDRPFFAGLVKYMHS

NME1

56

P15531
MHRTKQPIAYFFLGK

SAMD9

1471

Q5K651
YAYFRMGIKHPDIVK

MTERF4

236

Q7Z6M4
FMHQKLGIAYAIHKP

SP110

16

Q9HB58
VVKLMVPLLKFYFHD

RANBP6

711

O60518
FLIVFMEKAGYPLEH

SGPL1

321

O95470
KMPEKDLHEGFHYII

SERPINA12

106

Q8IW75
KYTMHKVFQFLNLGP

CHST15

486

Q7LFX5
KAIQAYGMKPHDIFE

CNN3

91

Q15417
MLIHEPFKKYKCPFS

ZNF341

641

Q9BYN7
GHPFKIFTKMAVVRY

TSR1

701

Q2NL82
AEFGKYGHIIKVFLM

RBMXL3

26

Q8N7X1
NAAGDFKLKPMLIYH

TIGD1

226

Q96MW7
MYHAPGKKREFNAFV

PWP2

121

Q15269
GKQPHLDMKYTVFGK

PPIL3

106

Q9H2H8
FFMPIYKSKHSEGVI

SPATA7

491

Q9P0W8
HPFLARYKVGFMKTG

XDH

841

P47989
LGHYITKPEMIFKLE

ZNF717

61

Q9BY31
KSLGLMIPYKYCKFH

TOPAZ1

1086

Q8N9V7
VLPFMEIGSVAHKFY

WLS

181

Q5T9L3
IIEKMARHTKGPEFY

TEX13B

21

Q9BXU2