Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenoparesis

NOTCH3 SCN8A

4.22e-055332MP:0000754
MousePhenomyopathy

NOTCH3 SCN8A

4.38e-055432MP:0000751
MousePhenomuscular atrophy

NOTCH3 SCN8A

1.39e-049632MP:0002269
MousePhenohydrocephaly

NOTCH3 SCN8A

6.61e-0420932MP:0001891
MousePhenoimpaired hearing

NOTCH3 SCN8A

7.52e-0422332MP:0006325
MousePhenoincreased or absent threshold for auditory brainstem response

NOTCH3 SCN8A

8.42e-0423632MP:0011967
MousePhenoincreased spleen weight

NOTCH3 SCN8A

9.75e-0425432MP:0004952
MousePhenoataxia

NOTCH3 SCN8A

1.07e-0326632MP:0001393
MousePhenoabnormal spleen weight

NOTCH3 SCN8A

1.96e-0336132MP:0004951
MousePhenoabnormal brain ventricular system morphology

NOTCH3 SCN8A

2.32e-0339332MP:0002200
MousePhenoabnormal skeletal muscle morphology

NOTCH3 SCN8A

3.86e-0350832MP:0000759
MousePhenoabnormal auditory brainstem response

NOTCH3 SCN8A

4.95e-0357632MP:0004738
MousePhenoabnormal hearing electrophysiology

NOTCH3 SCN8A

5.26e-0359432MP:0006335
MousePhenoabnormal brain development

NOTCH3 SCN8A

6.05e-0363832MP:0000913
MousePhenoabnormal hearing physiology

NOTCH3 SCN8A

6.14e-0364332MP:0001963
MousePhenoabnormal ear physiology

NOTCH3 SCN8A

6.94e-0368432MP:0003878
MousePhenoabnormal locomotor coordination

NOTCH3 SCN8A

7.80e-0372632MP:0003312
MousePhenoabnormal vertebral column morphology

NOTCH3 SCN8A

9.14e-0378732MP:0004703
DomainEGF

NOTCH3 FCGBP

9.30e-0423542SM00181
DomainEGF-like_dom

NOTCH3 FCGBP

1.04e-0324942IPR000742
Pubmed

Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.

NOTCH3 SCN8A

2.53e-05724225917818
InteractionPTDSS1 interactions

CRAT FCGBP

6.52e-0421242int:PTDSS1
CoexpressionGSE3720_UNSTIM_VS_LPS_STIM_VD1_GAMMADELTA_TCELL_DN

NOTCH3 SCN8A

1.84e-0414642M6341
CoexpressionGSE1791_CTRL_VS_NEUROMEDINU_IN_T_CELL_LINE_0.8H_DN

NOTCH3 SCN8A

3.24e-0419442M6163
CoexpressionGSE22025_UNTREATED_VS_TGFB1_TREATED_CD4_TCELL_UP

CRAT SCN8A

3.41e-0419942M8371
CoexpressionSANSOM_APC_TARGETS_DN

CRAT FCGBP

1.15e-0336642M1432
CoexpressionPATIL_LIVER_CANCER

NOTCH3 SCN8A

3.67e-0366042M1195
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Rectal_Adenocarcinoma|TCGA-Colorectal / Sample_Type by Project: Shred V9

FCGBP SCN8A

5.58e-0513842e1e936ff4080bda2810c5fd1154a706359f377a5
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_macrophage-Langerhans_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

NOTCH3 FCGBP

6.95e-0515442617ad0929d2ac0eeb7b8d9b0cba687176e684ed0
ToppCellClub_cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

NOTCH3 FCGBP

7.60e-0516142bd08a23b415617f6e8748ed2668d578a860ecf91
ToppCellClub_cells-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

NOTCH3 FCGBP

8.18e-0516742dbdaaeb3bd9139cb008d9fe24ec031fc5628f136
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRAT FCGBP

8.67e-05172425401ac7739f95fb8681cfb4747ab6e447a3c2ae8
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Microglia/Mac|metastatic_Lymph_Node / Location, Cell class and cell subclass

CRAT FCGBP

8.67e-0517242f673a2e697b46e7cfa4186cb3fb2b98e3c83703e
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRAT FCGBP

8.67e-0517242b3da7f488d191214d7bb74fbac189fe8c29ee6cd
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRAT FCGBP

8.67e-051724274dd4a7acb2cf857fed20219e4d7dc1adfbaa398
ToppCellAdult-Epithelial-lung_goblet_cell-D231|Adult / Lineage, Cell type, age group and donor

NOTCH3 FCGBP

8.88e-05174427d2f802f493f19a068e097b2909a9000e2160266
ToppCell5'-Adult-Distal_Rectal-Epithelial-goblet-BEST2+_Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FCGBP SCN8A

8.98e-0517542019ea30ac55748463d7917abf3d3f0e804189bfd
ToppCellClub_cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

NOTCH3 FCGBP

9.29e-0517842be64d4be23fb96a4cdd7980c58880fdfe817747f
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NOTCH3 SCN8A

9.40e-051794256db12467b445f2b8ef92af50779eeab10413eb2
ToppCell343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|343B / Donor, Lineage, Cell class and subclass (all cells)

NOTCH3 FCGBP

1.05e-0418942b06471b1bebb990d5146bddfb8002401c6b099a0
ToppCellE17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NOTCH3 SCN8A

1.05e-041894226cfe5b7e7f477f225f4e9f25f983f432f01e183
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NOTCH3 SCN8A

1.05e-0418942ca3a04c202afc32aa11d17154066ef7dc6d01405
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOTCH3 FCGBP

1.05e-041894227e5d706f10a6221f314faf642eede15deab3165
ToppCell343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|343B / Donor, Lineage, Cell class and subclass (all cells)

NOTCH3 FCGBP

1.05e-0418942a8246acf31f02c85421268245afb651aa8788f14
ToppCellE17.5-Mesenchymal-developing_mesenchymal_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NOTCH3 SCN8A

1.06e-04190422ab604d35456beba71c25511e0f819000e6642d2
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NOTCH3 SCN8A

1.06e-04190427e4d80a3a7f83b6a50f1d0fe82fb6c242c39d5b0
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOTCH3 FCGBP

1.06e-04190420bad41d19dc515e6bc61e699f4d56664cf2e72fd
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NOTCH3 SCN8A

1.06e-04190421004e89d99c9d46c78b7d3532d8d4aadb81a96fd
ToppCell(7)_Epithelial-G_(Club-Clara_cells)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

NOTCH3 FCGBP

1.06e-0419042593fd1451038b155826a48de4caa38f44406d0b9
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NOTCH3 SCN8A

1.06e-04190427fec459cd2ad12c2923a03d098289337c0a4c1d3
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CRAT FCGBP

1.07e-0419142529068029fb461df766135576dd0d8b5980f9bc0
ToppCell(7)_Epithelial_cells-(7)_Epithelial-G_(Club-Clara_cells)|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

NOTCH3 FCGBP

1.08e-0419242c7c232545fad8ad327ab94bd0def8dc5daacd03d
ToppCell343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NOTCH3 FCGBP

1.09e-04193420e7d7adfaa7191e34038fcda6677561ae13934eb
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOTCH3 FCGBP

1.09e-041934222ebc3f586eb0aabc5785e468c88d7416c624ff4
ToppCell343B-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NOTCH3 FCGBP

1.09e-04193428ede7038a222c7e7ecaf7e86520823cf606cbee7
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOTCH3 FCGBP

1.09e-04193421526f51b589a7dc7a28f35f0e788dc38d338d2bc
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOTCH3 FCGBP

1.10e-04194420ef63abcfd057079a9a6f8b27404ff521d44845d
ToppCellCOPD-Epithelial-Goblet|Epithelial / Disease state, Lineage and Cell class

NOTCH3 FCGBP

1.10e-041944272a2e0cba171ab59aa176e91a59a54c562af0390
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NOTCH3 SCN8A

1.11e-04195424a5d2f62aad5817d077177bf8b4ff0e46d3b8d97
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOTCH3 FCGBP

1.11e-041954225703e3c2e0512ef12e7aa389fad3968c3f13905
ToppCellEpithelial_cells-Club_cells|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

NOTCH3 FCGBP

1.11e-0419542b758676abfc4e6930b696d270ecc0ea461b87a54
ToppCellfacs-Mammary_Gland-Mammary_Gland-3m-Epithelial-luminal_epithelial_cell_of_mammary_gland|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOTCH3 FCGBP

1.11e-0419542c87edbb8c92a0541b6de2632ac2f9cef44c7e304
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NOTCH3 SCN8A

1.11e-04195427a32a8535c29b819dacba901d0658280a2631c94
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NOTCH3 FCGBP

1.13e-0419642e819088a74d29e958371aa851ac9c74ec55367b7
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NOTCH3 FCGBP

1.13e-0419642a4d05d85fbafa869df19bba3881020ea433d81fb
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

NOTCH3 FCGBP

1.13e-0419642e675d661b6494ac3a85ba7ee5bdeaa98b8bbe957
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NOTCH3 SCN8A

1.13e-04196426708026bafd19c35c5c4e81911344d36a0f508cd
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NOTCH3 FCGBP

1.13e-041964291a3c3091064f1f5a3bdc1dd5883fc24dce8ff05
ToppCellTracheal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

NOTCH3 CRAT

1.14e-0419742b67ffd27d386c8186ef71ecdac96a462504507f0
ToppCellMild_COVID-19-Epithelial-Basal/Club|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

NOTCH3 FCGBP

1.14e-04197424cc5b778e1e2c6c149160fa147c172977c0fa8eb
ToppCellParenchymal-NucSeq-Epithelial-Epi_submucosal-gland|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NOTCH3 FCGBP

1.15e-0419842fab3135f03cf23a9f04f0eed543a9dc181f39f5f
ToppCell(5)_Epithelial_cells-(5)_Epi_stratified|(5)_Epithelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

NOTCH3 CRAT

1.15e-0419842b3aec042912ce53bd86e86b6761a0604d9998ab5
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Club|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NOTCH3 FCGBP

1.16e-04199422b357cc08c425a58d45aa6c086101c8fff53e218
ToppCellBiopsy_Control_(H.)-Epithelial-MUC5AC+_High|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

NOTCH3 FCGBP

1.16e-0419942a5240868cea40574ed4ee45eb27a00c1812957ed
ToppCellBiopsy_Control_(H.)-Epithelial-MUC5B+|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

NOTCH3 FCGBP

1.16e-04199424ab45996e6bca406c77895a5998982b8ab1cf210
ToppCellParenchymal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NOTCH3 FCGBP

1.17e-0420042b992eeddee38e6fe3564e9b1850f6b20b89bf47d
DrugNitrendipine [39562-70-4]; Up 200; 11uM; HL60; HT_HG-U133A

NOTCH3 CRAT

4.20e-04192423087_UP
DrugChlorpromazine hydrochloride [69-09-0]; Down 200; 11.2uM; PC3; HT_HG-U133A

NOTCH3 SCN8A

4.24e-04193425074_DN
DrugFenbufen [36330-85-5]; Up 200; 15.8uM; MCF7; HT_HG-U133A

CRAT SCN8A

4.24e-04193424743_UP
Drugtrifluoperazine dihydrochloride; Up 200; 10uM; MCF7; HG-U133A

NOTCH3 CRAT

4.33e-0419542421_UP
DrugFenoprofen calcium salt dihydrate [53746-45-5]; Up 200; 7.2uM; HL60; HT_HG-U133A

NOTCH3 CRAT

4.33e-04195422553_UP
DrugButylparaben [94-26-8]; Up 200; 20.6uM; MCF7; HT_HG-U133A

NOTCH3 SCN8A

4.33e-04195425608_UP
DrugBenoxinate hydrochloride [5987-82-6]; Up 200; 11.6uM; PC3; HT_HG-U133A

NOTCH3 CRAT

4.37e-04196423996_UP
DrugFluvoxamine maleate [61718-82-9]; Up 200; 9.2uM; MCF7; HT_HG-U133A

NOTCH3 SCN8A

4.37e-04196424114_UP
DrugImipramine hydrochloride [113-52-0]; Down 200; 12.6uM; MCF7; HT_HG-U133A

NOTCH3 CRAT

4.37e-04196421685_DN
DrugDenatonium benzoate [3734-33-6]; Up 200; 9uM; HL60; HT_HG-U133A

NOTCH3 CRAT

4.37e-04196423123_UP
DrugBuspirone hydrochloride [33386-08-2]; Up 200; 9.4uM; MCF7; HT_HG-U133A

NOTCH3 SCN8A

4.42e-04197422637_UP
DrugAzaperone [1649-18-9]; Up 200; 12.2uM; MCF7; HT_HG-U133A

CRAT SCN8A

4.42e-04197423573_UP
DrugNomifensine maleate [32795-47-4]; Up 200; 11.2uM; MCF7; HT_HG-U133A

NOTCH3 CRAT

4.42e-04197427217_UP
DrugAceclofenac [89796-99-6]; Up 200; 11.2uM; PC3; HT_HG-U133A

NOTCH3 SCN8A

4.42e-04197422117_UP
DrugNorethindrone [68-22-4]; Down 200; 13.4uM; PC3; HT_HG-U133A

NOTCH3 SCN8A

4.42e-04197425055_DN
DrugIndomethacin [53-86-1]; Up 200; 11.2uM; PC3; HT_HG-U133A

NOTCH3 CRAT

4.42e-04197425049_UP
DrugMeticrane [1084-65-7]; Up 200; 14.6uM; MCF7; HT_HG-U133A

NOTCH3 SCN8A

4.46e-04198425984_UP
DrugParomomycin sulfate [1263-89-4]; Up 200; 5.6uM; HL60; HT_HG-U133A

CRAT SCN8A

4.46e-04198423017_UP
Drug5155877; Down 200; 10uM; PC3; HT_HG-U133A

NOTCH3 SCN8A

4.46e-04198426544_DN
DrugHippeastrine hydrobromide [22352-41-6]; Down 200; 10uM; PC3; HT_HG-U133A

NOTCH3 SCN8A

4.55e-04200423682_DN

Protein segments in the cluster

PeptideGeneStartEntry
EYLGGKPLCMNQYYQ

CRAT

161

P43155
GYMGGYMCECLPGYN

NOTCH3

1101

Q9UM47
PGNYYQLMCGLCGNY

FCGBP

3781

Q9Y6R7
GYQCMKAGRNPNYGY

SCN8A

336

Q9UQD0