Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	KMT2C KMT2D ASH1L PRDM16	1.04e-05	44	62	4	GO:0140938
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2C KMT2D ASH1L	3.13e-05	20	62	3	GO:0042800
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	KMT2C KMT2D ASH1L PRDM16	5.91e-05	68	62	4	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	KMT2C KMT2D ASH1L PRDM16	6.26e-05	69	62	4	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	KMT2C KMT2D ASH1L PRDM16	7.01e-05	71	62	4	GO:0042054
GeneOntologyMolecularFunction	histone H3K9 monomethyltransferase activity	ASH1L PRDM16	2.62e-04	8	62	2	GO:0140948
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2C KMT2D	2.62e-04	8	62	2	GO:0140945
GeneOntologyMolecularFunction	protein methyltransferase activity	KMT2C KMT2D ASH1L PRDM16	2.96e-04	103	62	4	GO:0008276
GeneOntologyMolecularFunction	N-methyltransferase activity	KMT2C KMT2D ASH1L PRDM16	3.19e-04	105	62	4	GO:0008170
GeneOntologyMolecularFunction	histone H3K9me2 methyltransferase activity	ASH1L PRDM16	4.20e-04	10	62	2	GO:0140947
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2C KMT2D	4.20e-04	10	62	2	GO:0140999
GeneOntologyMolecularFunction	histone H3K9 methyltransferase activity	ASH1L PRDM16	7.24e-04	13	62	2	GO:0046974
GeneOntologyMolecularFunction	phospholipid binding	IQGAP2 PLA2G15 PLEKHA8 ARHGAP33 GOT2 ITPR2 PSD4	1.50e-03	548	62	7	GO:0005543
GeneOntologyMolecularFunction	S-adenosylmethionine-dependent methyltransferase activity	KMT2C KMT2D ASH1L PRDM16	2.01e-03	172	62	4	GO:0008757
Domain	SET	KMT2C KMT2D ASH1L PRDM16	1.72e-05	46	63	4	SM00317
Domain	Post-SET_dom	KMT2C KMT2D ASH1L	1.99e-05	16	63	3	IPR003616
Domain	PostSET	KMT2C KMT2D ASH1L	1.99e-05	16	63	3	SM00508
Domain	POST_SET	KMT2C KMT2D ASH1L	1.99e-05	16	63	3	PS50868
Domain	SET_dom	KMT2C KMT2D ASH1L PRDM16	2.41e-05	50	63	4	IPR001214
Domain	SET	KMT2C KMT2D ASH1L PRDM16	2.41e-05	50	63	4	PS50280
Domain	FYrich_C	KMT2C KMT2D	1.11e-04	5	63	2	IPR003889
Domain	FYrich_N	KMT2C KMT2D	1.11e-04	5	63	2	IPR003888
Domain	FYRC	KMT2C KMT2D	1.11e-04	5	63	2	SM00542
Domain	FYRN	KMT2C KMT2D	1.11e-04	5	63	2	SM00541
Domain	FYRN	KMT2C KMT2D	1.11e-04	5	63	2	PF05964
Domain	FYRC	KMT2C KMT2D	1.11e-04	5	63	2	PF05965
Domain	FYRC	KMT2C KMT2D	1.11e-04	5	63	2	PS51543
Domain	FYRN	KMT2C KMT2D	1.11e-04	5	63	2	PS51542
Domain	PHD	KMT2C KMT2D RSF1 ASH1L	1.19e-04	75	63	4	PF00628
Domain	Znf_PHD-finger	KMT2C KMT2D RSF1 ASH1L	1.46e-04	79	63	4	IPR019787
Domain	PHD	KMT2C KMT2D RSF1 ASH1L	2.32e-04	89	63	4	SM00249
Domain	Znf_PHD	KMT2C KMT2D RSF1 ASH1L	2.52e-04	91	63	4	IPR001965
Domain	ZF_PHD_2	KMT2C KMT2D RSF1 ASH1L	2.97e-04	95	63	4	PS50016
Domain	ZF_PHD_1	KMT2C KMT2D RSF1 ASH1L	3.10e-04	96	63	4	PS01359
Domain	SET	KMT2C KMT2D ASH1L	3.56e-04	41	63	3	PF00856
Domain	PSI	MST1R SEMA3B ITGB5	4.39e-04	44	63	3	IPR016201
Domain	PSI	MST1R SEMA3B ITGB5	5.01e-04	46	63	3	SM00423
Domain	BAH	ASH1L RERE	6.04e-04	11	63	2	SM00439
Domain	BAH	ASH1L RERE	6.04e-04	11	63	2	PF01426
Domain	BAH	ASH1L RERE	6.04e-04	11	63	2	PS51038
Domain	BAH_dom	ASH1L RERE	6.04e-04	11	63	2	IPR001025
Domain	Znf_FYVE_PHD	KMT2C KMT2D RSF1 ASH1L	1.53e-03	147	63	4	IPR011011
Domain	EPHD	KMT2C KMT2D	2.48e-03	22	63	2	PS51805
Domain	IPT	MST1R NFKB1	3.72e-03	27	63	2	SM00429
Domain	AT_hook	KMT2C ASH1L	3.72e-03	27	63	2	SM00384
Domain	AT_hook_DNA-bd_motif	KMT2C ASH1L	3.72e-03	27	63	2	IPR017956
Domain	TIG	MST1R NFKB1	4.89e-03	31	63	2	PF01833
Domain	Sema	MST1R SEMA3B	4.89e-03	31	63	2	SM00630
Domain	Semap_dom	MST1R SEMA3B	4.89e-03	31	63	2	IPR001627
Domain	HMGI/Y_DNA-bd_CS	KMT2C RELL2	4.89e-03	31	63	2	IPR000637
Domain	Sema	MST1R SEMA3B	4.89e-03	31	63	2	PF01403
Domain	SEMA	MST1R SEMA3B	4.89e-03	31	63	2	PS51004
Domain	PSI	MST1R SEMA3B	5.20e-03	32	63	2	PF01437
Domain	IPT	MST1R NFKB1	5.20e-03	32	63	2	IPR002909
Domain	Plexin_repeat	MST1R SEMA3B	5.20e-03	32	63	2	IPR002165
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	KMT2C KMT2D NFKB1 ASH1L PRDM16	3.41e-06	70	47	5	M27231
Pathway	REACTOME_PKMTS_METHYLATE_HISTONE_LYSINES	KMT2D NFKB1 ASH1L PRDM16	1.60e-05	46	47	4	MM14933
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2C KMT2D ASH1L	3.31e-07	8	64	3	23130995
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MST1R KMT2C KMT2D VWA8 POLE PRAG1 GBA2 PRDM16 ITGB5 ARHGAP33 PRRC2B ITPR2	7.14e-07	1105	64	12	35748872
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	KMT2C KMT2D ARID5B U2AF2 RERE TOP2B	3.30e-06	220	64	6	35785414
Pubmed	Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.	KMT2C KMT2D	3.33e-06	2	64	2	28483418
Pubmed	Functional interaction between nuclear matrix-associated HBXAP and NF-kappaB.	NFKB1 RSF1	3.33e-06	2	64	2	15242768
Pubmed	The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.	KMT2C KMT2D	3.33e-06	2	64	2	34156443
Pubmed	Curcumin blocks RON tyrosine kinase-mediated invasion of breast carcinoma cells.	MST1R NFKB1	3.33e-06	2	64	2	18593918
Pubmed	KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.	KMT2C KMT2D	3.33e-06	2	64	2	31924266
Pubmed	Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.	KMT2C KMT2D	3.33e-06	2	64	2	27280393
Pubmed	Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.	KMT2C KMT2D	3.33e-06	2	64	2	36869380
Pubmed	Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.	KMT2C KMT2D	3.33e-06	2	64	2	28967912
Pubmed	VARS2 V552V variant as prognostic marker in patients with early breast cancer.	POLE VARS2	3.33e-06	2	64	2	20503108
Pubmed	The Ron receptor tyrosine kinase regulates acute lung injury and suppresses nuclear factor kappaB activation.	MST1R NFKB1	3.33e-06	2	64	2	17304108
Pubmed	Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.	KMT2C KMT2D	3.33e-06	2	64	2	25346535
Pubmed	Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.	KMT2C KMT2D	3.33e-06	2	64	2	36601880
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	KMT2D DHX40 U2AF2 PRDM16 TOP2B STAU1	4.71e-06	234	64	6	36243803
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	VWA8 NAF1 RSF1 ASH1L U2AF2 CHD9 RERE PRDM16 GARRE1 ARHGAP33 PRRC2B	5.54e-06	1116	64	11	31753913
Pubmed	Pro-inflammatory cytokine tumor necrosis factor-alpha induces bone morphogenetic protein-2 in chondrocytes via mRNA stabilization and transcriptional up-regulation.	BMP2 NFKB1	9.99e-06	3	64	2	16835229
Pubmed	[NF-kappaB modulates activation of the BMP-2 gene by trichostatin A].	BMP2 NFKB1	9.99e-06	3	64	2	19140318
Pubmed	Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.	KMT2C KMT2D	9.99e-06	3	64	2	23932714
Pubmed	Independent and cooperative roles of tumor necrosis factor-alpha, nuclear factor-kappaB, and bone morphogenetic protein-2 in regulation of metastasis and osteomimicry of prostate cancer cells and differentiation and mineralization of MC3T3-E1 osteoblast-like cells.	BMP2 NFKB1	9.99e-06	3	64	2	19811499
Pubmed	Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma.	KMT2C KMT2D	9.99e-06	3	64	2	22183980
Pubmed	Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growth.	NFKB1 BBC3	9.99e-06	3	64	2	22286758
Pubmed	NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro.	BMP2 NFKB1	9.99e-06	3	64	2	12759356
Pubmed	HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.	KMT2C KMT2D	9.99e-06	3	64	2	21683083
Pubmed	Inflammatory Cytokines Stimulate Bone Morphogenetic Protein-2 Expression and Release from Pancreatic Beta Cells.	BMP2 NFKB1	9.99e-06	3	64	2	26308798
Pubmed	Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis.	BMP2 ARID5B PRDM16	1.33e-05	25	64	3	29475039
Pubmed	Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.	KMT2C KMT2D	2.00e-05	4	64	2	19221051
Pubmed	Cancer gene mutation frequencies for the U.S. population.	KMT2C KMT2D	2.00e-05	4	64	2	34645806
Pubmed	Transcription factor Ap2delta associates with Ash2l and ALR, a trithorax family histone methyltransferase, to activate Hoxc8 transcription.	KMT2D TFAP2D	2.00e-05	4	64	2	18495928
Pubmed	Effect of PI3K/Akt Signaling Pathway on the Process of Prostate Cancer Metastasis to Bone.	BMP2 NFKB1	2.00e-05	4	64	2	27040945
Pubmed	MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.	KMT2C KMT2D	2.00e-05	4	64	2	28398509
Pubmed	Inhibition of BMP2-induced bone formation by the p65 subunit of NF-κB via an interaction with Smad4.	BMP2 NFKB1	2.00e-05	4	64	2	25029242
Pubmed	A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.	KMT2C KMT2D	2.00e-05	4	64	2	23129768
Pubmed	The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.	KMT2C KMT2D	2.00e-05	4	64	2	24081332
Pubmed	Double-edged-sword effect of IL-1β on the osteogenesis of periodontal ligament stem cells via crosstalk between the NF-κB, MAPK and BMP/Smad signaling pathways.	BMP2 NFKB1	2.00e-05	4	64	2	27415426
Pubmed	Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.	KMT2C KMT2D	3.32e-05	5	64	2	31127101
Pubmed	Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity.	ASH1L PRDM16	3.32e-05	5	64	2	22939622
Pubmed	MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.	KMT2C KMT2D	3.32e-05	5	64	2	32601106
Pubmed	The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells.	MST1R NFKB1	3.32e-05	5	64	2	19838218
Pubmed	MSP-induced RON activation upregulates uPAR expression and cell invasiveness via MAPK, AP-1 and NF-κB signals in gastric cancer cells.	MST1R NFKB1	3.32e-05	5	64	2	21081472
Pubmed	A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.	KMT2C KMT2D	3.32e-05	5	64	2	26744420
Pubmed	Interaction network of human early embryonic transcription factors.	KMT2C KMT2D ARID5B RERE PRDM16 PRRC2B	4.64e-05	351	64	6	38297188
Pubmed	Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.	KMT2C KMT2D	4.98e-05	6	64	2	17021013
Pubmed	Human transcription factor protein interaction networks.	KMT2C KMT2D DHX40 NFKB1 ARID5B YY2 RERE PRDM16 GARRE1 PRRC2B STAU1	5.44e-05	1429	64	11	35140242
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	DHX40 NAF1 RSF1 ASH1L CHD9 TOP2B GOT2	5.57e-05	533	64	7	30554943
Pubmed	USP7 Regulates Cytokinesis through FBXO38 and KIF20B.	DHX40 POLE ARID5B PRRC2B	6.40e-05	116	64	4	30804394
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	KMT2C KMT2D RERE	6.96e-05	43	64	3	33472061
Pubmed	Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.	KMT2C KMT2D	6.96e-05	7	64	2	30604749
Pubmed	Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.	KMT2C KMT2D	6.96e-05	7	64	2	36598580
Pubmed	ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.	KMT2C KMT2D	6.96e-05	7	64	2	19556342
Pubmed	Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.	KMT2C KMT2D	9.27e-05	8	64	2	21447625
Pubmed	H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development.	KMT2C KMT2D	9.27e-05	8	64	2	30335158
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2C KMT2D	9.27e-05	8	64	2	22266653
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	IQGAP2 POLE U2AF2 TOP2B GOT2 STAU1	9.52e-05	400	64	6	35013556
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2C KMT2D	1.19e-04	9	64	2	22665483
Pubmed	Fibromodulin is expressed by both chondrocytes and osteoblasts during fetal bone development.	BMP2 FMOD	1.19e-04	9	64	2	11400162
Pubmed	Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos.	BMP2 TBX20	1.49e-04	10	64	2	15162503
Pubmed	Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice.	LETMD1 PRDM16	1.49e-04	10	64	2	37353518
Pubmed	New nomenclature for chromatin-modifying enzymes.	KMT2C KMT2D ASH1L	1.62e-04	57	64	3	18022353
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	KMT2D DHX40 POLE RSF1 ARID5B YY2 PRRC2B	1.70e-04	638	64	7	31182584
Pubmed	MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.	KMT2C KMT2D	1.81e-04	11	64	2	37012455
Pubmed	Nuclear export factor family protein participates in cytoplasmic mRNA trafficking.	U2AF2 STAU1	1.81e-04	11	64	2	16014633
Pubmed	Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2.	BMP2 TBX20	2.17e-04	12	64	2	17259303
Pubmed	Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal.	BMP2 TBX20	2.17e-04	12	64	2	19661464
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	KMT2C KMT2D	2.17e-04	12	64	2	27563068
Pubmed	Interplay of BAF and MLL4 promotes cell type-specific enhancer activation.	KMT2D PRDM16	2.17e-04	12	64	2	33712604
Pubmed	RERE deficiency leads to decreased expression of GATA4 and the development of ventricular septal defects.	BMP2 RERE	2.17e-04	12	64	2	30061196
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	KMT2C KMT2D POLE NFKB1 RSF1 TOP2B	2.25e-04	469	64	6	27634302
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	MST1R PXDN PLA2G15 ITGB5	2.43e-04	164	64	4	32409323
Pubmed	Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.	KMT2C KMT2D	2.57e-04	13	64	2	21502505
Pubmed	Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.	KMT2C KMT2D	2.57e-04	13	64	2	17761849
Pubmed	Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.	KMT2C ASH1L	2.57e-04	13	64	2	24619213
Pubmed	Canonical wnt signaling regulates atrioventricular junction programming and electrophysiological properties.	BMP2 TBX20	2.57e-04	13	64	2	25599332
Pubmed	CHIP as a membrane-shuttling proteostasis sensor.	ARHGAP33 PRRC2B STAU1	2.73e-04	68	64	3	29091030
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	PXDN IQGAP2 VWA8 HDHD5 NFKB1 GARRE1 TOP2B PRRC2B STAU1 ITPR2	2.83e-04	1440	64	10	30833792
Pubmed	FGF2 High Molecular Weight Isoforms Contribute to Osteoarthropathy in Male Mice.	BMP2 NFKB1	2.99e-04	14	64	2	27732085
Pubmed	Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo.	SESN3 BBC3	2.99e-04	14	64	2	31749402
Pubmed	Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.	KMT2C KMT2D	2.99e-04	14	64	2	12482968
Pubmed	Fate and function of the ventral ectodermal ridge during mouse tail development.	BMP2 FGF19	2.99e-04	14	64	2	10769235
Pubmed	Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication.	POLE TOP2B	3.45e-04	15	64	2	12393188
Pubmed	Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes.	NFKB1 PRKCG	3.45e-04	15	64	2	8627654
Pubmed	The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.	KMT2C KMT2D	3.45e-04	15	64	2	17925232
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	VWA8 HDHD5 POLE U2AF2 VARS2 RERE MAGT1 PRRC2B STAU1 ITPR2	3.83e-04	1496	64	10	32877691
Pubmed	The sacral autonomic outflow is sympathetic.	SLC18A3 TBX20	3.93e-04	16	64	2	27856909
Pubmed	[HIV-1 Tat protein induces IL-10 production by human monocytes: implications of the PKC and calcium pathway].	NFKB1 PRKCG	3.93e-04	16	64	2	11833470
Pubmed	H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.	KMT2C KMT2D	3.93e-04	16	64	2	24368734
Pubmed	MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.	KMT2C KMT2D	4.45e-04	17	64	2	26180087
Pubmed	A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease.	BMP2 TBX20	4.45e-04	17	64	2	11572777
Pubmed	A cluster of cholinergic premotor interneurons modulates mouse locomotor activity.	KCNB1 SLC18A3	4.45e-04	17	64	2	20005822
Pubmed	Chromatin remodelling complex dosage modulates transcription factor function in heart development.	BMP2 TBX20	4.45e-04	17	64	2	21304516
Pubmed	PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.	KMT2C KMT2D	5.00e-04	18	64	2	17500065
Pubmed	Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci.	VARS2 PRRT1	5.00e-04	18	64	2	19116923
Pubmed	The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.	VWA8 HDHD5 U2AF2 STAU1	5.44e-04	203	64	4	35012549
Pubmed	Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment.	BMP2 VARS2 FGF19	5.45e-04	86	64	3	19501082
Pubmed	Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation.	SLC18A3 TBX20	5.59e-04	19	64	2	21068058
Pubmed	GATA5 interacts with GATA4 and GATA6 in outflow tract development.	BMP2 TBX20	6.20e-04	20	64	2	21839733
Pubmed	Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathway.	NFKB1 PRKCG	6.20e-04	20	64	2	11044099
Pubmed	Chromatin-remodeling factor, RSF1, controls p53-mediated transcription in apoptosis upon DNA strand breaks.	RSF1 BBC3	6.20e-04	20	64	2	30348983
Pubmed	PRDM16 Is a Compact Myocardium-Enriched Transcription Factor Required to Maintain Compact Myocardial Cardiomyocyte Identity in Left Ventricle.	TBX20 PRDM16	6.20e-04	20	64	2	34915728
Interaction	GSC interactions	KMT2C KMT2D ARID5B RERE PRDM16	7.12e-06	87	62	5	int:GSC
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2C KMT2D ASH1L PRDM16	1.00e-06	34	41	4	487
GeneFamily	PHD finger proteins	KMT2C KMT2D RSF1 ASH1L	5.05e-05	90	41	4	88
Coexpression	GSE24671_CTRL_VS_SENDAI_VIRUS_INFECTED_MOUSE_SPLENOCYTES_DN	KMT2C KMT2D IQGAP2 ARID5B PRRT1 PRRC2B	8.42e-06	199	63	6	M9443
Coexpression	BAELDE_DIABETIC_NEPHROPATHY_DN	BMP2 LETMD1 IQGAP2 SEMA3B ARID5B PAM ITGB5 TOP2B	9.72e-06	437	63	8	M4665
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RELL2 SEMA3B PRAG1 PRDM16 PIGZ	1.15e-06	128	64	5	2cf0384240a4a663869cf6b27d954236f6214a9a
ToppCell	AT1-AT2_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	MST1R PXDN SRRM4 UPK3B SEMA3B	4.89e-06	172	64	5	0be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	VWA8 MAGT1 GARRE1 PRRC2B ITPR2	7.16e-06	186	64	5	74c238759c5d3fd39127ec0060d0c2cb16b326d4
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEMA3B CPM PRDM16 ITPR2 PSD4	8.14e-06	191	64	5	f3158cedf67e3b90aa94ea1f61c72c33aaa2d5ba
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2 FMOD ADAMTS2 PAM ITGB5	8.14e-06	191	64	5	1b26056df078674f37a6c06f6256b30cfcec21a7
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMOD ADAMTS2 SEMA3B PAM ITGB5	8.35e-06	192	64	5	b35f0e422070ba9c7c1d9ff3eace4edc10286cde
ToppCell	Fibroblasts-DKK3+_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	FMOD PXDN ADAMTS2 PAM ITGB5	9.69e-06	198	64	5	4f4632f26a2043c5e4ab89031b4229b5dca1bd48
ToppCell	Epithelial_cells-AT1-AT2_cells\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	PXDN UPK3B SEMA3B PAM PRAG1	9.69e-06	198	64	5	fbc46b20bcd44f2083170aacbc6f5dd00fba685c
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AHI1-DT CPM ADCY5 PSD4	5.36e-05	143	64	4	7a7a9829ba63468c9745904d9e993590051207ab
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ARID5B SESN3 PRAG1 GARRE1	8.09e-05	159	64	4	b9d34b9ed8db798f5ea93c44b469cae499403cb8
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	NAF1 SEMA3B ARID5B CPM	8.09e-05	159	64	4	af137688e06a97ff97bb7def54f0dd164d155b11
ToppCell	P07-Mesenchymal-developing_mesenchymal_cell-mesenchymal_mature_unknown_2\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FMOD ARID5B GBA2 PIGZ	8.29e-05	160	64	4	68b477525eeef99430382ff0a6745cac91364bc2
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	VWA8 ARID5B SESN3 ILDR1	8.49e-05	161	64	4	22fea192cd5f6d3544533d8b10e1d74dfedf0f05
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-4\|TCGA-Lung / Sample_Type by Project: Shred V9	FMOD PXDN ADAMTS2 ARID5B	1.00e-04	168	64	4	aefea14b8b1c1b6a05f827effd22ba15274fddc9
ToppCell	Ionocyte-iono-2\|World / Class top	BMP2 NFKB1 ADCY5 ITPR2	1.12e-04	173	64	4	e5ec28ccc5e048fd98de4c876e5c53b866b66228
ToppCell	AT1_cells-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	BMP2 PXDN SEMA3B PAM	1.22e-04	177	64	4	3128b8d04687acee1ac4190b2569d6328b98eaf3
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	VWA8 CPM PRDM16 ADCY5	1.31e-04	180	64	4	9e09b3dfe344b5d50520711513d389865d73a861
ToppCell	10x5'-bone_marrow-Myeloid_Mac-Macrophage\|bone_marrow / Manually curated celltypes from each tissue	HDHD5 BRI3 CPM ITGB5	1.33e-04	181	64	4	d2aa5b53162fb5c4cbbedbd2cb4b2b614e8c4afa
ToppCell	droplet-Spleen-nan-18m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASH1L CHD9 TOP2B ITPR2	1.36e-04	182	64	4	eeb5dfa4539e9ca5220f26bc2b65717ddcf13b6c
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2 FMOD UPK3B SEMA3B	1.39e-04	183	64	4	ebe369dc80c4fbf8f4dbe947147f8c47507ffb60
ToppCell	droplet-Liver-LIVER_HEP-30m-Mesenchymal\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 PAM TBX20 ADCY5	1.45e-04	185	64	4	f814ec9d4ade717a0109398e9768d0d66f09317b
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	PXDN ADAMTS2 PAM PRAG1	1.45e-04	185	64	4	427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VWA8 CPM PRDM16 ADCY5	1.45e-04	185	64	4	03f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCell	droplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 PAM TBX20 ADCY5	1.45e-04	185	64	4	40e958511790e84321da5ccf735f9974c06a0263
ToppCell	droplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 PAM TBX20 ADCY5	1.45e-04	185	64	4	5f2eeba80aff145e85cfd81e2890a155406badb9
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RSF1 CHD9 CPM TOP2B	1.45e-04	185	64	4	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRDM16 FREM1 PLEKHA8 ITPR2	1.48e-04	186	64	4	a6ef5d5944af5689b5f27bef89cd05645eedbe50
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VWA8 CPM PRDM16 ADCY5	1.48e-04	186	64	4	1850583d23903d08226aeb0edb3e07b0994330e4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VWA8 CPM PRDM16 ADCY5	1.48e-04	186	64	4	4dafc215c42e7949f932a3627359c107943b5d6b
ToppCell	IPF-Epithelial-ATI\|Epithelial / Disease state, Lineage and Cell class	UPK3B SEMA3B PAM CPM	1.48e-04	186	64	4	d436ee6cabbde8553ec5e6e55022274090d9f41a
ToppCell	15-Trachea-Epithelial-Secretory_progenitor\|Trachea / Age, Tissue, Lineage and Cell class	BMP2 FMOD PAM CPM	1.51e-04	187	64	4	be9fce9e74b2f170a2067f1b31d802912a578329
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	VWA8 U2AF2 GARRE1 ITPR2	1.51e-04	187	64	4	816d37a70f7ec382a268fe828b3dfe737a36a4bf
ToppCell	CD8+_Memory_T_cell-CV-4\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	HDHD5 PAM CPM PSD4	1.51e-04	187	64	4	9c2fc2f259fa7d3a65fb99c295ac378e03d9aa6c
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SEMA3B CPM PRAG1 PRDM16	1.54e-04	188	64	4	eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCell	10x5'-GI_large-bowel-Myeloid_Monocytic\|GI_large-bowel / Manually curated celltypes from each tissue	ADAMTS2 BRI3 PLA2G15 ITGB5	1.54e-04	188	64	4	d0045fdda757d191dabc7853f6a6e99c0e97d93d
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NFKB1 NAF1 ARID5B SESN3	1.54e-04	188	64	4	939790f133eac9c12d08db6ddb5f08f5107844e3
ToppCell	10x5'-GI_large-bowel-Myeloid_Monocytic-Classical_monocytes\|GI_large-bowel / Manually curated celltypes from each tissue	ADAMTS2 BRI3 PLA2G15 ITGB5	1.54e-04	188	64	4	0bcf04aa47738f43c1a87dae5dc487738ee86f8c
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SEMA3B PAM CPM PRAG1	1.54e-04	188	64	4	43a3a59f92ad93509d4166bd025aed0b1b39a008
ToppCell	Fibroblast-C\|World / shred on cell class and cell subclass (v4)	FMOD ADAMTS2 UPK3B PAM	1.57e-04	189	64	4	58e0400fbab5a0755504275aef5cf7986149abab
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SEMA3B CPM PRDM16 PSD4	1.61e-04	190	64	4	2de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCell	10x3'2.3-week_12-13-Lymphocytic_B-B_lineage-pro_B_progenitor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	PXDN ARID5B CHD9 TOP2B	1.61e-04	190	64	4	f623f0bdece6002b68ac2207e99408b24a2b1194
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IQGAP2 PXYLP1 PRDM16 FREM1	1.64e-04	191	64	4	3e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASH1L CHD9 TOP2B ITPR2	1.64e-04	191	64	4	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	10x5'v1-week_12-13-Lymphocytic_B-B_lineage-pro_B_progenitor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	PXDN ARID5B CHD9 TOP2B	1.64e-04	191	64	4	054fa0493b00149313c243d39cf39a264044f074
ToppCell	P07-Mesenchymal-mesenchymal_fibroblast\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADAMTS2 ARID5B CPM FREM1	1.64e-04	191	64	4	a05e9a7eb137d804570dd7d8905975d735738767
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS2 PAM TBX20 ITGB5	1.64e-04	191	64	4	4b50fdd310701251e64e16cd2d07ce03dbfd3e3e
ToppCell	droplet-Heart-nan-24m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 PAM TBX20 ITGB5	1.64e-04	191	64	4	1f660ea2841324d13f63e01f1789e606c2843fc4
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS2 PAM TBX20 ITGB5	1.64e-04	191	64	4	75d2197076a9dfc868e8baf95bd4c5e44f438e3e
ToppCell	Control-Myeloid-Macrophage_Alveolar\|Myeloid / Disease state, Lineage and Cell class	VWA8 CHD9 PRAG1 PLA2G15	1.64e-04	191	64	4	a7bb8aba9c59c037d995a77928cc7b4d5cbb82b9
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASH1L CHD9 TOP2B ITPR2	1.64e-04	191	64	4	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2 PXDN KCNB1 GARRE1	1.67e-04	192	64	4	2bfac6b3956265205ca47d06888851ed68b65999
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2 PXDN KCNB1 GARRE1	1.67e-04	192	64	4	d525f7f088a53110912600a7c9f6d33b9270d534
ToppCell	droplet-Pancreas-Endocrine-21m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MST1R ADAMTS2 PIGZ FREM1	1.71e-04	193	64	4	59b8186d0221fba06a16157e9d148399ed801f38
ToppCell	droplet-Pancreas-Endocrine-21m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MST1R ADAMTS2 PIGZ FREM1	1.71e-04	193	64	4	dc92680b4bb9fc26430c92e03adb839c8c3b3b98
ToppCell	droplet-Pancreas-Endocrine-21m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MST1R ADAMTS2 PIGZ FREM1	1.71e-04	193	64	4	03678162648bd5b1d65a5450b60c8863edbf95c7
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2 PXDN KCNB1 GARRE1	1.74e-04	194	64	4	c8b9551b93a5aed62154b487db90130604a6125c
ToppCell	facs-Heart-RA-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 PAM TBX20 ITGB5	1.74e-04	194	64	4	48063c9fe3e12aeff0707acada1baa2f8621f093
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IQGAP2 PXYLP1 PRDM16 FREM1	1.74e-04	194	64	4	04bfc555743f7d8821439d05ae442d15e9886c59
ToppCell	facs-Heart-RA-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 PAM TBX20 ITGB5	1.74e-04	194	64	4	c422aeddb4e949a22f731da675bdf91dee86ba61
ToppCell	facs-Heart-RA-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 PAM TBX20 ITGB5	1.74e-04	194	64	4	4f31d2cf7eb37b45fefc4da5b41aac0bfdd847b3
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IQGAP2 PXYLP1 PRDM16 FREM1	1.74e-04	194	64	4	69bff17df4a760ccf081cf52ff04af02c14f448d
ToppCell	PND07-28-samps-Mesenchymal\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ADAMTS2 PAM CPM FREM1	1.74e-04	194	64	4	68bcc1fe8dc8d5f23a12154fc9b41362fdef0b1d
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2C KCNB1 ASH1L RERE	1.77e-04	195	64	4	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	(3)_Chondrocytes-(34)_Chondro-progen\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	BMP2 FMOD PAM CPM	1.77e-04	195	64	4	d00cb2fab25f2026a9668a7f0686938a2e7155e2
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KMT2C KCNB1 ASH1L RERE	1.77e-04	195	64	4	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	facs-Bladder-nan-3m\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 PAM ITGB5 TOP2B	1.81e-04	196	64	4	44f5b1b474399c9316729155f2ea95a82ca66e30
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMOD ADAMTS2 TBX20 ITGB5	1.81e-04	196	64	4	59b5b5a0c123d0423abd19c312514849004b903b
ToppCell	distal-3-Epithelial-Ionocyte\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ILDR1 PXYLP1 PIGZ ADCY5	1.81e-04	196	64	4	6ed146481dd04fb271eadc47d68eb3ae38986db6
ToppCell	wk_08-11-Epithelial-PNS-TM4SF4+_PENK+_neuron\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	SLC18A3 SRRM4 TBX20 BBC3	1.81e-04	196	64	4	afa3a2f5f3a51d1830c6f95f97a4b3e13ed42512
ToppCell	facs-Bladder-nan-3m-Epithelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 PAM ITGB5 TOP2B	1.81e-04	196	64	4	c0e90d964baa2eb4fbd18a52379ccec5d3bf59a8
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2 PXDN KCNB1 GARRE1	1.84e-04	197	64	4	deefb492b5f0e6014144bd465c4a6ae4206e8739
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMOD ADAMTS2 TBX20 ITGB5	1.84e-04	197	64	4	b16add329bb35a558287ede51353010dde5bc029
ToppCell	mLN-T_cell-Treg\|T_cell / Region, Cell class and subclass	ARID5B SESN3 PAM CPM	1.84e-04	197	64	4	3779489d57ebda33277c79cba037f4c73128c8ba
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG\|World / Primary Cells by Cluster	IQGAP2 PXYLP1 PRDM16 ITGB5	1.84e-04	197	64	4	61749ccafeb938c310cff1de5ff924a1c794325a
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2 PXDN KCNB1 GARRE1	1.84e-04	197	64	4	a6aaa6faea348291023f0bc4b0f83fbc67d91da6
ToppCell	distal-Epithelial-Ionocyte\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ILDR1 PXYLP1 PIGZ ADCY5	1.84e-04	197	64	4	11a5d2db2561d045756980ead61e1211c7dda100
ToppCell	(1)_T_cell-(15)_Treg\|(1)_T_cell / shred on Cell_type and subtype	ARID5B SESN3 PAM CPM	1.84e-04	197	64	4	6e7723e8b977be35c60cc11ac7cfa4f71339441e
ToppCell	(3)_Chondrocytes-(34)_Chondro-progen\|(3)_Chondrocytes / Cell class and subclass of bone marrow stroma cells in homeostatis	BMP2 PAM CPM ITGB5	1.84e-04	197	64	4	012c49a57f9c2a3dfa988cd3882c8c6b7ef3a5ad
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG-25\|World / Primary Cells by Cluster	IQGAP2 PXYLP1 PRDM16 ITGB5	1.84e-04	197	64	4	9d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCell	distal-Epithelial-Ionocyte-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ILDR1 PXYLP1 PIGZ ADCY5	1.84e-04	197	64	4	7a2cd970fe0866057999e40d15367b2b3324ae59
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	VARS2 PRAG1 PSD4	1.86e-04	77	64	3	ebb1a537751739232820a60f88911877fc683855
ToppCell	AT1-AT2_cells\|World / lung cells shred on cell class, cell subclass, sample id	PXDN UPK3B SEMA3B PAM	1.88e-04	198	64	4	a5b3617ea2ed4bffba59edcf6284799c2b3bbb29
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-B_(Myofibroblast)\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	FMOD ADAMTS2 PAM PXYLP1	1.88e-04	198	64	4	196257c4420ac801ed9fbb444f11718adb7560ae
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_macrophage\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ADAMTS2 BRI3 CPM ITGB5	1.88e-04	198	64	4	c08018f099a381a66993cb60288954a6e47f105f
ToppCell	mLN-(1)_T_cell-(15)_Treg\|mLN / shred on region, Cell_type, and subtype	ARID5B SESN3 PAM CPM	1.88e-04	198	64	4	d4885f9c59b275e4e50dfcfb51c5351bebba1769
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ADAMTS2 BRI3 CPM ITGB5	1.88e-04	198	64	4	27cc7f786fb8cb230589d762a4e51b46265c1f19
ToppCell	mLN-T_cell-Treg\|mLN / Region, Cell class and subclass	ARID5B SESN3 PAM CPM	1.88e-04	198	64	4	6ce9681d1287632956176239f223e71abb8de44f
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2 PXDN KCNB1 GARRE1	1.88e-04	198	64	4	f0f1816a0ed3ae8207442602f5cbe4de0382e4b3
ToppCell	Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	PXDN ADAMTS2 PAM ITGB5	1.92e-04	199	64	4	40de6d4a31cf22efa2864f79e4ec8e2b7bfc9d4a
ToppCell	droplet-Limb_Muscle-nan-3m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMOD SEMA3B PAM ITGB5	1.92e-04	199	64	4	edd5300da1a3b758210ff8f949e9d1988b8bc7e2
ToppCell	Biopsy_IPF-Epithelial-Transitional_AT2\|Biopsy_IPF / Sample group, Lineage and Cell type	UPK3B SEMA3B PAM CPM	1.92e-04	199	64	4	83ff8b7e472d1212324c05cc719b746d19e5e23b
ToppCell	(07)_Ionocytes\|World / shred by cell type by condition	PXDN IQGAP2 ADCY5 ITPR2	1.92e-04	199	64	4	8194777d367405a7840787e977854b5c07e3bd6b
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	KMT2C VWA8 RERE ITPR2	1.92e-04	199	64	4	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ADAMTS2 BRI3 CPM ITGB5	1.92e-04	199	64	4	80ed217d28ba1c07facd0e103c25a02658dd848d
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	IQGAP2 NFKB1 ARID5B BBC3	1.92e-04	199	64	4	f3cc3cda38f78d1d12d865df339d93c5fecf19f2
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	IQGAP2 NFKB1 ARID5B BBC3	1.92e-04	199	64	4	c3c73c9404a73133bfad1f9ced292f5e508ef767
ToppCell	(2)_Fibroblasts-(24)_Fibro-5\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	FMOD ADAMTS2 PAM ITGB5	1.92e-04	199	64	4	6c0354f57883330c685a8d9d5d3014ace7eca584
ToppCell	facs-Trachea-nan-3m-Mesenchymal\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2 ADAMTS2 PAM ITGB5	1.92e-04	199	64	4	67f78c070c56e44fba36542041bf7fa1c291807c
ToppCell	facs-Trachea-nan-3m-Mesenchymal-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2 ADAMTS2 PAM ITGB5	1.92e-04	199	64	4	1ae244b563f85c1ee8d22698f478c842a4d9c7f5
ToppCell	tumor_Lung-Myeloid_cells-mo-Mac\|Myeloid_cells / Location, Cell class and cell subclass	IQGAP2 BRI3 CPM PLA2G15	1.95e-04	200	64	4	58ff8db0ecf71daa86f9a38208e0d9b712cac0b5
Drug	(-)-Cinchonidine [485-71-2]; Up 200; 13.6uM; HL60; HG-U133A	FMOD PXDN ADAMTS2 PAM U2AF2 BBC3 PLA2G15 ARHGAP33	8.61e-08	199	64	8	1780_UP
Disease	Kleefstra syndrome 2 (implicated_via_orthology)	KMT2C KMT2D	4.20e-06	2	61	2	DOID:0080598 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	KMT2C KMT2D CHD9 TBX20	1.29e-05	69	61	4	DOID:1682 (implicated_via_orthology)
Disease	Chromosome 1p36 Deletion Syndrome	RERE PRDM16	4.19e-05	5	61	2	C1842870
Disease	C-reactive protein measurement	MST1R AHI1-DT PXDN NFKB1 RERE PRAG1 ADCY5 TOP2B ARHGAP33 PSD4	1.69e-04	1206	61	10	EFO_0004458
Disease	lung non-small cell carcinoma (is_implicated_in)	KMT2C KMT2D POLE NFKB1	2.00e-04	139	61	4	DOID:3908 (is_implicated_in)
Disease	phoneme awareness	KCNB1 STAU1	3.76e-04	14	61	2	EFO_0021812
Disease	reaction time measurement	KMT2D TFAP2D IQGAP2 ADAMTS2 ARID5B RERE STAU1	4.08e-04	658	61	7	EFO_0008393
Disease	Trigonocephaly	BMP2 FREM1	4.95e-04	16	61	2	C0265535
Disease	Scaphycephaly	BMP2 FREM1	4.95e-04	16	61	2	C0265534
Disease	Synostotic Posterior Plagiocephaly	BMP2 FREM1	4.95e-04	16	61	2	C1833340
Disease	Synostotic Anterior Plagiocephaly	BMP2 FREM1	4.95e-04	16	61	2	C2931150
Disease	Metopic synostosis	BMP2 FREM1	4.95e-04	16	61	2	C1860819
Disease	Craniosynostosis, Type 1	BMP2 FREM1	4.95e-04	16	61	2	C4551902
Disease	Acrocephaly	BMP2 FREM1	4.95e-04	16	61	2	C0030044
Disease	Brachycephaly	BMP2 FREM1	5.60e-04	17	61	2	C0221356
Disease	alcoholic hepatitis (biomarker_via_orthology)	NFKB1 FGF19	6.30e-04	18	61	2	DOID:12351 (biomarker_via_orthology)
Disease	Craniosynostosis	BMP2 FREM1	7.80e-04	20	61	2	C0010278
Disease	lymphocyte count	MST1R IQGAP2 NFKB1 ARID5B ILDR1 VARS2 RERE ADCY5 ITPR2 PSD4	7.83e-04	1464	61	10	EFO_0004587
Disease	QT interval	PXDN KCNB1 TBX20 PRRC2B STAU1 ITPR2	8.17e-04	534	61	6	EFO_0004682
Disease	waist-hip ratio	BMP2 TFAP2D ADAMTS2 SEMA3B ARID5B PAM RERE PRDM16 ADCY5	8.88e-04	1226	61	9	EFO_0004343
Disease	Neurodevelopmental Disorders	KMT2C ASH1L ADCY5	9.56e-04	93	61	3	C1535926
Disease	Thyroid preparation use measurement	AHI1-DT NFKB1 ARID5B ILDR1	1.07e-03	217	61	4	EFO_0009933
Disease	stomach carcinoma (is_marker_for)	KMT2C LETMD1	1.13e-03	24	61	2	DOID:5517 (is_marker_for)
Disease	lung squamous cell carcinoma (is_implicated_in)	KMT2D POLE	1.13e-03	24	61	2	DOID:3907 (is_implicated_in)
Disease	glucose measurement	VWA8 PAM PXYLP1 PRDM16 ADCY5	1.14e-03	380	61	5	EFO_0004468
Disease	migraine disorder, diastolic blood pressure	PRDM16 ITGB5	1.22e-03	25	61	2	EFO_0006336, MONDO_0005277
Disease	systemic lupus erythematosus	AHI1-DT SRRM4 ARID5B CHD9 RERE PRRT1 PRAG1	1.27e-03	799	61	7	MONDO_0007915
Disease	Sezary Syndrome	KMT2C KMT2D	1.43e-03	27	61	2	C0036920
Disease	neutrophil percentage of leukocytes	NFKB1 ARID5B BRI3 PXYLP1 RERE ADCY5	1.61e-03	610	61	6	EFO_0007990
Disease	JT interval	PXDN NFKB1 TBX20 STAU1	1.75e-03	248	61	4	EFO_0007885
Disease	lymphocyte measurement	NFKB1 ARID5B RERE	1.85e-03	117	61	3	EFO_0803546
Disease	cup-to-disc ratio measurement	BMP2 ARID5B RERE PRAG1 PRDM16	1.96e-03	430	61	5	EFO_0006939
Disease	cortical thickness	BMP2 ADAMTS2 NFKB1 PAM CPM RERE ITGB5 STAU1	2.00e-03	1113	61	8	EFO_0004840
Disease	neutrophil count	MST1R ASH1L BRI3 PAM CHD9 PXYLP1 RERE FGF19 ITPR2	2.04e-03	1382	61	9	EFO_0004833

Protein segments in the cluster

Peptide	Gene	Start	Entry
MLLEHYGLAGQPSPL	TMEM62	21	Q0P6H9
PLYAQLMPHSGLSRP	nan	26	Q75L30
LYNLIMGLLPLPRGH	BBC3	171	Q9BXH1
LPPPSYMHAGHLLLN	ASH1L	1421	Q9NR48
MDHKPLLQERPPAYN	BRI3	1	O95415
LHLTRLPQPLIAGMY	PAM	186	P19021
GHFLYLQPPAPLIMP	AHI1-DT	221	P0C7V0
MLAFHAARPPLQLPY	ADCY5	256	O95622
RRPLHSMPLYPPDYL	CCM2L	36	Q9NUG4
PPYMLDLYRRHSGQP	BMP2	76	P12643
PALPQLPGLHYSMNE	ADAMTS2	476	O95450
MHPDQRLLPGPSLGL	TFAP2D	156	Q7Z6R9
MGLHLRPYRVGLLPD	PLA2G15	1	Q8NCC3
MHDYPPLLSGALQLL	ITPR2	1066	Q14571
YLDHNNLTRMPGPLP	FMOD	161	Q06828
YGRNPLMELPLAVNP	KMT2C	4691	Q8NEZ4
IRPPNYAGPLMLGLL	MAGT1	181	Q9H0U3
MLLTSYLPPPLLRHR	LETMD1	261	Q6P1Q0
LGLHLPLPFLLAYMP	OR51S1	161	Q8NGJ8
NRGFLPLSHFLPMLP	FGF19	156	O95750
LLMGLRYQHLDPPSP	FREM1	241	Q5H8C1
YPMHPLLQRDLSLPS	ILDR1	251	Q86SU0
RNLIPMDPNGLSDPY	PRKCG	181	P05129
MFPVLPGSHLLLNNP	POLE	2086	Q07864
LLYRTPPGSPQLAML	PLEKHA8	181	Q96JA3
MPRAPAPLYACLLGL	ITGB5	1	P18084
MLGQSPPLHRSPDFL	ARHGAP33	1121	O14559
ILYPGMLLTPGLNLH	CHD9	2801	Q3L8U1
PSPLLPVLGMYHDPL	KCNB1	681	Q14721
PMIPLYRNLPDHSAA	CPM	411	P14384
GLLLHHPTLPNPYTM	GBA2	321	Q9HCG7
QYPMPELGRALSAPL	GARRE1	31	O15063
RLGLSMVEFPLPPHL	DHX40	481	Q8IX18
LALLEPRRPPHDYMP	PRRT1	211	Q99946
YHTACLRPPLMIIPD	RSF1	916	Q96T23
RHPLMGQPLPLITDY	VARS2	366	Q5ST30
PDLEPPQHGLYMLFL	RELL2	6	Q8NC24
LPVGTPIHRLMLDPY	SLC18A3	276	Q16572
LDGLDPHPMLPNYKN	TOP2B	901	Q02880
MPHEELPSLQRPRYG	IQGAP2	1	Q13576
YLRPSPLLFHPQMSA	PRDM16	886	Q9HAZ2
PYPHLPVLASNMDLL	HDHD5	226	Q9BXW7
RLPDHPQPMEILNLY	PSD4	6	Q8NDX1
LPLYPNHPLCEMGEL	PXYLP1	151	Q8TE99
NHPFYMPLNPTDPLL	RERE	1271	Q9P2R6
ADLILSYHPPIFRPM	NIF3L1	86	Q9GZT8
LIRPMYSNPPLNGAR	GOT2	311	P00505
PLLYSRGNPGIMSPL	ARID5B	676	Q14865
PYLSHQQLPAGILPM	STAU1	406	O95793
PLMYNSVLPTGGRPL	SEMA3B	406	Q13214
GPLPLPYRHYIAIMA	SESN3	101	P58005
PPSQPLQMLGYLSAR	SRRM4	241	A7MD48
YGGHNHPPLMVLQPL	YY2	51	O15391
INPHRLYNGHALPMP	PXDN	781	Q92626
LTMPLPRYGSGQQPL	PRRC2B	2076	Q5JSZ5
YMPPRHLLHLPGLGA	PIGZ	466	Q86VD9
PPAYTMVGLHNLEPR	PRAG1	156	Q86YV5
IRRPHDYQPLPGMSE	U2AF2	226	P26368
HPIQGSLPPYSRLGM	TBX20	381	Q9UMR3
PKPHSELEMLRQYGP	VWA8	931	A3KMH1
DGHYMTLPLSPDQLP	UPK3B	156	Q9BT76
LPPEGLPHVLLPYMC	MST1R	1151	Q04912
YGRHPLMELPLMINP	KMT2D	5321	O14686
MAAHPLLNLPYSLPP	NAF1	456	Q96HR8
PYLGRPEQMFHLDPS	NFKB1	6	P19838