Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	extracellular matrix structural constituent conferring tensile strength	COL4A3 COL4A6 COL16A1 COL22A1	1.25e-05	46	62	4	GO:0030020
GeneOntologyMolecularFunction	ATP-dependent activity	SETX ATAD1 LONP2 NSF MOV10L1 NVL PSMC2 FIGNL1 DNAH1	1.10e-04	614	62	9	GO:0140657
GeneOntologyMolecularFunction	flavin adenine dinucleotide binding	DUS2 ACAD8 ETFDH NOS3	2.08e-04	94	62	4	GO:0050660
GeneOntologyMolecularFunction	ATP hydrolysis activity	ATAD1 LONP2 NSF MOV10L1 NVL PSMC2 FIGNL1	4.22e-04	441	62	7	GO:0016887
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	ATAD1 LONP2 NSF MOV10L1 RAB1C NVL PSMC2 RAB1B FIGNL1	6.12e-04	775	62	9	GO:0017111
GeneOntologyMolecularFunction	protein-containing complex destabilizing activity	NSF FIGNL1	9.70e-04	15	62	2	GO:0140776
GeneOntologyMolecularFunction	pyrophosphatase activity	ATAD1 LONP2 NSF MOV10L1 RAB1C NVL PSMC2 RAB1B FIGNL1	1.07e-03	839	62	9	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	ATAD1 LONP2 NSF MOV10L1 RAB1C NVL PSMC2 RAB1B FIGNL1	1.08e-03	840	62	9	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	ATAD1 LONP2 NSF MOV10L1 RAB1C NVL PSMC2 RAB1B FIGNL1	1.08e-03	840	62	9	GO:0016818
GeneOntologyMolecularFunction	FMN binding	DUS2 NOS3	1.11e-03	16	62	2	GO:0010181
GeneOntologyCellularComponent	collagen type IV trimer	COL4A3 COL4A6	1.29e-04	6	62	2	GO:0005587
GeneOntologyCellularComponent	collagen trimer	COL4A3 COL4A6 COL16A1 COL22A1	1.36e-04	88	62	4	GO:0005581
GeneOntologyCellularComponent	basement membrane collagen trimer	COL4A3 COL4A6	2.40e-04	8	62	2	GO:0098651
GeneOntologyCellularComponent	network-forming collagen trimer	COL4A3 COL4A6	2.40e-04	8	62	2	GO:0098642
GeneOntologyCellularComponent	collagen network	COL4A3 COL4A6	2.40e-04	8	62	2	GO:0098645
GeneOntologyCellularComponent	endoplasmic reticulum lumen	COL4A3 COL4A6 COL16A1 COL22A1 ADAMTS5 F7	4.46e-04	332	62	6	GO:0005788
Domain	AAA	ATAD1 LONP2 NSF NVL PSMC2 FIGNL1	1.71e-08	52	61	6	PF00004
Domain	ATPase_AAA_core	ATAD1 LONP2 NSF NVL PSMC2 FIGNL1	2.16e-08	54	61	6	IPR003959
Domain	ATPase_AAA_CS	ATAD1 NSF NVL PSMC2 FIGNL1	3.51e-08	29	61	5	IPR003960
Domain	AAA	ATAD1 NSF NVL PSMC2 FIGNL1	8.13e-08	34	61	5	PS00674
Domain	AAA+_ATPase	ATAD1 LONP2 NSF NVL PSMC2 FIGNL1	7.41e-06	144	61	6	IPR003593
Domain	AAA	ATAD1 LONP2 NSF NVL PSMC2 FIGNL1	7.41e-06	144	61	6	SM00382
Domain	-	SETX ATAD1 LONP2 NSF MOV10L1 NVL PSMC2 RAB1B FIGNL1 DNAH1	1.39e-04	746	61	10	3.40.50.300
Domain	C4	COL4A3 COL4A6	1.56e-04	6	61	2	SM00111
Domain	-	COL4A3 COL4A6	1.56e-04	6	61	2	2.170.240.10
Domain	Collagen_VI_NC	COL4A3 COL4A6	1.56e-04	6	61	2	IPR001442
Domain	C4	COL4A3 COL4A6	1.56e-04	6	61	2	PF01413
Domain	NC1_IV	COL4A3 COL4A6	1.56e-04	6	61	2	PS51403
Domain	Collagen	COL4A3 COL4A6 COL16A1 COL22A1	1.71e-04	85	61	4	IPR008160
Domain	Collagen	COL4A3 COL4A6 COL16A1 COL22A1	1.71e-04	85	61	4	PF01391
Domain	P-loop_NTPase	SETX ATAD1 LONP2 NSF MOV10L1 NVL PSMC2 RAB1B FIGNL1 DNAH1	3.88e-04	848	61	10	IPR027417
Domain	TSPN	COL16A1 COL22A1	2.54e-03	23	61	2	SM00210
Domain	CARD	CARD9 CASP9	3.76e-03	28	61	2	PF00619
Domain	CARD	CARD9 CASP9	4.59e-03	31	61	2	IPR001315
Domain	CTDL_fold	COL4A3 COL4A6 TNFAIP6	5.17e-03	107	61	3	IPR016187
Domain	CARD	CARD9 CASP9	5.19e-03	33	61	2	PS50209
Pathway	REACTOME_COLLAGEN_CHAIN_TRIMERIZATION	COL4A3 COL4A6 COL16A1 COL22A1	1.00e-05	41	47	4	MM15538
Pathway	REACTOME_COLLAGEN_CHAIN_TRIMERIZATION	COL4A3 COL4A6 COL16A1 COL22A1	1.34e-05	44	47	4	M27812
Pathway	BIOCARTA_AMI_PATHWAY	COL4A3 COL4A6 F7	3.81e-05	20	47	3	M15394
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL4A3 COL4A6 COL16A1 COL22A1	4.92e-05	61	47	4	MM14637
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL4A3 COL4A6 COL16A1 COL22A1	7.13e-05	67	47	4	M26999
Pathway	PID_AVB3_INTEGRIN_PATHWAY	COL4A3 COL4A6 COL16A1 IRS1	1.05e-04	74	47	4	M160
Pathway	REACTOME_COLLAGEN_FORMATION	COL4A3 COL4A6 COL16A1 COL22A1	1.17e-04	76	47	4	MM14573
Pathway	REACTOME_COLLAGEN_FORMATION	COL4A3 COL4A6 COL16A1 COL22A1	2.25e-04	90	47	4	M631
Pathway	REACTOME_TRNA_MODIFICATION_IN_THE_NUCLEUS_AND_CYTOSOL	DUS2 THADA ADAT1	3.90e-04	43	47	3	M27602
Pathway	PID_SYNDECAN_1_PATHWAY	COL4A3 COL4A6 COL16A1	4.77e-04	46	47	3	M198
Pathway	BIOCARTA_NPP1_PATHWAY	COL4A3 COL4A6	4.81e-04	10	47	2	M22040
Pathway	BIOCARTA_NPP1_PATHWAY	COL4A3 COL4A6	4.81e-04	10	47	2	MM1560
Pathway	BIOCARTA_VITCB_PATHWAY	COL4A3 COL4A6	5.87e-04	11	47	2	M15422
Pathway	BIOCARTA_VITCB_PATHWAY	COL4A3 COL4A6	7.03e-04	12	47	2	MM1526
Pathway	BIOCARTA_ACE2_PATHWAY	COL4A3 COL4A6	8.29e-04	13	47	2	MM1347
Pathway	BIOCARTA_ACE2_PATHWAY	COL4A3 COL4A6	8.29e-04	13	47	2	M12950
Pathway	WP_FEMALE_STEROID_HORMONES_IN_CARDIOMYOCYTE_ENERGY_METABOLISM	ACLY NOS3	9.65e-04	14	47	2	M48059
Pathway	BIOCARTA_PLATELETAPP_PATHWAY	COL4A3 COL4A6	9.65e-04	14	47	2	MM1458
Pathway	BIOCARTA_PLATELETAPP_PATHWAY	COL4A3 COL4A6	9.65e-04	14	47	2	M6487
Pathway	REACTOME_ANCHORING_FIBRIL_FORMATION	COL4A3 COL4A6	1.11e-03	15	47	2	M27161
Pathway	REACTOME_LAMININ_INTERACTIONS	COL4A3 COL4A6	1.11e-03	15	47	2	MM14922
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	COL4A3 COL4A6 COL16A1 ADAMTS5	1.19e-03	140	47	4	M587
Pathway	REACTOME_COLLAGEN_DEGRADATION	COL4A3 COL4A6 COL16A1	1.25e-03	64	47	3	M26953
Pubmed	A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).	CCR2 COL4A3 COL4A6 IRS1 F7 NOS3	1.03e-06	186	62	6	20673868
Pubmed	Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.	CCR2 COL4A3 COL4A6 IRS1 F7 NOS3	1.03e-06	186	62	6	20452482
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	PARP10 FLNC NIBAN1 ATAD1 NSF ACLY ETFDH RAB1C IQSEC1 IRS1 RAB1B CBX4 ADAMTS5	1.36e-06	1451	62	13	30550785
Pubmed	Impaired endothelial function in never-treated hypertensive subjects carrying the Arg972 polymorphism in the insulin receptor substrate-1 gene.	IRS1 NOS3	3.13e-06	2	62	2	15240653
Pubmed	A Small-Scale shRNA Screen in Primary Mouse Macrophages Identifies a Role for the Rab GTPase Rab1b in Controlling Salmonella Typhi Growth.	RAB1C RAB1B	3.13e-06	2	62	2	33898333
Pubmed	Histone H3 Serine 10 Phosphorylation Facilitates Endothelial Activation in Diabetic Kidney Disease.	CCR2 NOS3	3.13e-06	2	62	2	30213824
Pubmed	Polymorphisms of chemokine receptors and eNOS in Brazilian patients with sickle cell disease.	CCR2 NOS3	9.37e-06	3	62	2	16305685
Pubmed	Genetic polymorphisms and cerebral palsy in very preterm infants.	F7 NOS3	9.37e-06	3	62	2	15718364
Pubmed	Identification of CAP as a costameric protein that interacts with filamin C.	FLNC SORBS1	9.37e-06	3	62	2	17898075
Pubmed	COL4A6 is dispensable for autosomal recessive Alport syndrome.	COL4A3 COL4A6	9.37e-06	3	62	2	27377778
Pubmed	NVL: a new member of the AAA family of ATPases localized to the nucleus.	NSF NVL	9.37e-06	3	62	2	9286697
Pubmed	AMPA Receptor Surface Expression Is Regulated by S-Nitrosylation of Thorase and Transnitrosylation of NSF.	ATAD1 NSF	9.37e-06	3	62	2	33147468
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	MON2 CUL4A ATAD1 DSG2 NSF RAB1C IQSEC1 RAB1B	1.20e-05	606	62	8	36538041
Pubmed	RAB GTPases expressed in human melanoma cells.	RAB1C RAB1B	1.87e-05	4	62	2	9030196
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MON2 FOCAD FLNC TNRC18 THADA ZBED4 IRS1 TTC3 ADAT1 HR	2.41e-05	1105	62	10	35748872
Pubmed	Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?	OXT APOL5 IRS1 TNFAIP6 NOS3	2.44e-05	192	62	5	20602615
Pubmed	CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior.	OXT NOS3	3.12e-05	5	62	2	33846232
Pubmed	Human umbilical cord expresses several vasoactive peptides involved in the local regulation of vascular tone: protein and gene expression of Orphanin, Oxytocin, ANP, eNOS and iNOS.	OXT NOS3	3.12e-05	5	62	2	21744319
Pubmed	Prognosis of young ischemic stroke in Taiwan: impact of prothrombotic genetic polymorphisms.	F7 NOS3	3.12e-05	5	62	2	15351855
Pubmed	Stimulation of extracellular matrix components in the normal brain by invading glioma cells.	COL4A3 COL4A6	4.67e-05	6	62	2	9506531
Pubmed	Rheb and mTOR regulate neuronal polarity through Rap1B.	RAB1C RAB1B	4.67e-05	6	62	2	18842593
Pubmed	Extracellular matrix of the human optic nerve head.	COL4A3 COL4A6	4.67e-05	6	62	2	2426947
Pubmed	Angiogenesis and collagen type IV expression in different endothelial cell culture systems.	COL4A3 COL4A6	4.67e-05	6	62	2	23551189
Pubmed	Monoclonal antibody to human basement membrane collagen type IV.	COL4A3 COL4A6	4.67e-05	6	62	2	6811420
Pubmed	Immunolocalization of collagen types, laminin and fibronectin in the normal human pancreas.	COL4A3 COL4A6	4.67e-05	6	62	2	6389236
Pubmed	Collagen IV in the developing lens capsule.	COL4A3 COL4A6	4.67e-05	6	62	2	12225806
Pubmed	Insertional mutation of the collagen genes Col4a3 and Col4a4 in a mouse model of Alport syndrome.	COL4A3 COL4A6	4.67e-05	6	62	2	10534397
Pubmed	A tumor derived motility factor that stimulates cell migration on extracellular matrix.	COL4A3 COL4A6	4.67e-05	6	62	2	9673377
Pubmed	Localization of type IV collagen a 1 to a 6 chains in basement membrane during mouse molar germ development.	COL4A3 COL4A6	4.67e-05	6	62	2	11732842
Pubmed	Developmental distribution of collagen IV isoforms and relevance to ocular diseases.	COL4A3 COL4A6	4.67e-05	6	62	2	19275937
Pubmed	Distribution of basement membrane proteins in normal and fibrotic human liver: collagen type IV, laminin, and fibronectin.	COL4A3 COL4A6	4.67e-05	6	62	2	6988303
Pubmed	A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus.	CASP9 IRS1 NOS3	5.08e-05	40	62	3	12732844
Pubmed	Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.	THADA CARD9 FIGNL1 SP140	5.64e-05	116	62	4	21102463
Pubmed	Interstitial collagens I, III, and VI sequester and modulate the multifunctional cytokine oncostatin M.	COL4A3 COL4A6	6.53e-05	7	62	2	11711546
Pubmed	Regulation of protease nexin-1 target protease specificity by collagen type IV.	COL4A3 COL4A6	6.53e-05	7	62	2	8006028
Pubmed	Corneal cell proteins and ocular surface pathology.	COL4A3 COL4A6	6.53e-05	7	62	2	10416788
Pubmed	Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface.	COL4A3 COL4A6	6.53e-05	7	62	2	1724753
Pubmed	Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals.	COL4A3 COL4A6	6.53e-05	7	62	2	17418794
Pubmed	During Aspergillus Infection, Monocyte-Derived DCs, Neutrophils, and Plasmacytoid DCs Enhance Innate Immune Defense through CXCR3-Dependent Crosstalk.	CCR2 CARD9	6.53e-05	7	62	2	32485165
Pubmed	Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II.	COL4A3 COL4A6	8.69e-05	8	62	2	3997552
Pubmed	Risks of human conotruncal heart defects associated with 32 single nucleotide polymorphisms of selected cardiovascular disease-related genes.	F7 NOS3	8.69e-05	8	62	2	16100725
Pubmed	Type IV collagen α6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium.	COL4A3 COL4A6	8.69e-05	8	62	2	29422532
Pubmed	Screening the single nucleotide polymorphisms in patients with internal carotid artery stenosis by oligonucleotide-based custom DNA array.	CCR2 NOS3	8.69e-05	8	62	2	20066125
Pubmed	Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV.	COL4A3 COL4A6	8.69e-05	8	62	2	1377218
Pubmed	A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly.	CUL4A ASF1B	8.69e-05	8	62	2	24209620
Pubmed	Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth.	COL4A3 COL4A6	8.69e-05	8	62	2	10382266
Pubmed	Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons.	COL4A3 COL4A6	8.69e-05	8	62	2	10970885
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MON2 FOCAD ZBED4 SORBS1 ZSWIM6 CSMD3	8.75e-05	407	62	6	12693553
Pubmed	MMP-9 from TNF alpha-stimulated keratinocytes binds to cell membranes and type I collagen: a cause for extended matrix degradation in inflammation?	COL4A3 COL4A6	1.12e-04	9	62	2	9878537
Pubmed	Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.	COL4A3 COL4A6	1.12e-04	9	62	2	12101409
Pubmed	A candidate gene study of obstructive sleep apnea in European Americans and African Americans.	HTR3C IRS1 NOS3	1.12e-04	52	62	3	20538960
Pubmed	A candidate gene association study of 77 polymorphisms in migraine.	CCR2 F7 NOS3	1.12e-04	52	62	3	19559392
Pubmed	Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients.	CCR2 F7 NOS3	1.25e-04	54	62	3	20536507
Pubmed	Clinical factors such as B-type natriuretic peptide link to factor VII, endothelial NO synthase and estrogen receptor alpha polymorphism in elderly women.	F7 NOS3	1.39e-04	10	62	2	19560472
Pubmed	Urocortin expression in the Edinger-Westphal nucleus is up-regulated by stress and corticotropin-releasing hormone deficiency.	PSMC2 NOS3	1.39e-04	10	62	2	10614646
Pubmed	Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans.	COL4A3 COL4A6	1.39e-04	10	62	2	9136074
Pubmed	Hemostatic gene polymorphisms in young Sardinian with non-fatal acute myocardial infarction.	F7 NOS3	1.39e-04	10	62	2	20036902
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CUL4A SETX DSG2 CCSER2 IQSEC1 IRS1 SORBS1 CBX4	1.42e-04	861	62	8	36931259
Pubmed	Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.	CCR2 F7 NOS3	1.47e-04	57	62	3	19263529
Pubmed	Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling.	CCR2 F7 NOS3	1.47e-04	57	62	3	19479237
Pubmed	Association of genetic variants with chronic kidney disease in individuals with different lipid profiles.	CCR2 IRS1 F7 NOS3	1.61e-04	152	62	4	19578796
Pubmed	Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.	MON2 PARP10 HAUS6 RAB1C RAB1B SP140	1.64e-04	457	62	6	32968282
Pubmed	Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.	COL4A3 COL4A6 COL16A1 F7	1.65e-04	153	62	4	25037231
Pubmed	Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development.	COL4A3 COL4A6	1.70e-04	11	62	2	14998921
Pubmed	Binding of mouse and human fibulin-2 to extracellular matrix ligands.	COL4A3 COL4A6	1.70e-04	11	62	2	7500359
Pubmed	Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation.	NSF IRS1	1.70e-04	11	62	2	12832401
Pubmed	Developmental regulation of membrane traffic organization during synaptogenesis in mouse diaphragm muscle.	RAB1C RAB1B	1.70e-04	11	62	2	7642711
Pubmed	An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity.	CCR2 CARD9	1.70e-04	11	62	2	35148840
Pubmed	Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis of common complex disease.	CCR2 F7 NOS3	1.72e-04	60	62	3	12082592
Pubmed	Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.	COL4A3 COL4A6 COL16A1	1.89e-04	62	62	3	28344315
Pubmed	Matrilin-2 interacts with itself and with other extracellular matrix proteins.	COL4A3 COL4A6	2.04e-04	12	62	2	12180907
Pubmed	Basement membrane fragility underlies embryonic lethality in fukutin-null mice.	COL4A3 COL4A6	2.04e-04	12	62	2	15837576
Pubmed	XIAP and PHB1 Regulate Anoikis through Competitive Binding to TRAF6.	ACLY RAB1B	2.04e-04	12	62	2	36346305
Pubmed	Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice.	COL4A3 COL4A6	2.04e-04	12	62	2	16024816
Pubmed	A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.	CCR2 F7 NOS3	2.08e-04	64	62	3	19131662
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	TNRC18 THADA COL16A1 DSG2 LONP2 PSMC2 COL22A1	2.22e-04	689	62	7	36543142
Pubmed	mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.	FLNC NIBAN1 NSF ACLY PSMC2	2.40e-04	312	62	5	37120454
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	COL4A3 COL4A6 COL16A1 COL22A1	2.75e-04	175	62	4	28071719
Pubmed	Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism.	ACAD8 ETFDH	2.81e-04	14	62	2	35727412
Pubmed	Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors.	COL4A3 COL4A6	2.81e-04	14	62	2	12878203
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	FLNC OXT APOL5 RAB1C RAB1B	3.06e-04	329	62	5	17474147
Pubmed	Rap1b Is an Effector of Axin2 Regulating Crosstalk of Signaling Pathways During Skeletal Development.	RAB1C RAB1B	3.23e-04	15	62	2	28520221
Pubmed	Causal relationship of susceptibility genes to ischemic stroke: comparison to ischemic heart disease and biochemical determinants.	F7 NOS3	3.69e-04	16	62	2	20161734
Pubmed	Unpackaging the genetics of mammalian fertility: strategies to identify the "reproductive genome".	SETX DNAH1	3.69e-04	16	62	2	29878059
Pubmed	Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle.	COL4A3 COL4A6	3.69e-04	16	62	2	15878328
Pubmed	Dectin-2-induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis.	CCR2 CARD9	3.69e-04	16	62	2	31169521
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	CUL4A FLNC ATXN7L2 ATAD1 LONP2 NSF PSMC2 F7	4.02e-04	1005	62	8	19615732
Pubmed	A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN).	CCR2 IRS1 NOS3	4.02e-04	80	62	3	19420105
Pubmed	Lp(a) and risk of recurrent cardiac events in obese postinfarction patients.	F7 NOS3	4.18e-04	17	62	2	18927546
Pubmed	Dioxin receptor is a ligand-dependent E3 ubiquitin ligase.	CUL4A PSMC2	5.24e-04	19	62	2	17392787
Pubmed	Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development.	COL4A3 COL4A6	5.24e-04	19	62	2	15689378
Pubmed	A mitochondrial protein compendium elucidates complex I disease biology.	DUS2 ACAD8 ATAD1 ACLY ETFDH RAB1C RAB1B HCCS	5.26e-04	1047	62	8	18614015
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	COL4A3 COL4A6 COL16A1 ADAMTS5	5.48e-04	210	62	4	16537572
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	COL4A3 FLNC ACLY MOV10L1 RAB1B HARS1 DNAH1	5.73e-04	807	62	7	30575818
Pubmed	Can we predict top-level sports performance in power vs endurance events? A genetic approach.	DSG2 NOS3	5.82e-04	20	62	2	20459474
Pubmed	Human immunodeficiency virus type 1 Vpr: functions and molecular interactions.	CUL4A CASP9	5.82e-04	20	62	2	19458171
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	CCR2 NIBAN1 ACAD8 CARD9 MOV10L1 SORBS1 HR	6.03e-04	814	62	7	23251661
Pubmed	The Wilms tumor gene, Wt1, maintains testicular cord integrity by regulating the expression of Col4a1 and Col4a2.	COL4A3 COL4A6	6.42e-04	21	62	2	23325811
Pubmed	Candidate genes and cerebral palsy: a population-based study.	F7 NOS3	6.42e-04	21	62	2	18977990
Pubmed	RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells.	CUL4A ASF1B	6.42e-04	21	62	2	21113133
Cytoband	22q13.33	ZBED4 MOV10L1	1.22e-03	38	62	2	22q13.33
Cytoband	13q34	CUL4A F7	2.45e-03	54	62	2	13q34
GeneFamily	AAA ATPases	ATAD1 LONP2 NSF NVL PSMC2 FIGNL1	2.66e-09	53	43	6	413
GeneFamily	Collagens	COL4A3 COL4A6 COL16A1 COL22A1	4.21e-06	46	43	4	490
GeneFamily	UPF1 like RNA helicases	SETX MOV10L1	3.00e-04	11	43	2	1169
GeneFamily	WD repeat domain containing\|Caspase recruitment domain containing\|Apoptosome	CARD9 CASP9	2.30e-03	30	43	2	959
Coexpression	NABA_COLLAGENS	COL4A3 COL4A6 COL16A1 COL22A1	3.27e-06	43	62	4	MM17060
Coexpression	NABA_COLLAGENS	COL4A3 COL4A6 COL16A1 COL22A1	3.59e-06	44	62	4	M3005
Coexpression	ZHANG_BREAST_CANCER_PROGENITORS_UP	ZIK1 SETX ATAD1 DSG2 NVL HARS1 TTC3 FIGNL1	8.19e-06	434	62	8	M15150
Coexpression	ZHANG_BREAST_CANCER_PROGENITORS_UP	ZIK1 SETX ATAD1 DSG2 NVL HARS1 TTC3 FIGNL1	1.03e-05	448	62	8	MM1044
ToppCell	Mesenchymal-airway_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	COL4A6 FLNC COL16A1 IRS1 SORBS1 ADAMTS5	2.65e-07	190	62	6	645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|normal_Lung / Location, Cell class and cell subclass	FLNC COL16A1 MOV10L1 SLC12A8 IRS1	5.80e-06	184	62	5	0b336489c10e8c3c957795dd845454f03404382b
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FLNC COL16A1 IRS1 ADAMTS5 HR	6.44e-06	188	62	5	c29aaae3c5bb7cd6b9b3defd4d27afde3af19ba0
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FLNC COL16A1 IRS1 SORBS1 ADAMTS5	6.44e-06	188	62	5	4d1e5f85342ae550086609d7680e32730b78b5d2
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_T_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NIBAN1 ZBED4 GZMM CCSER2 ADAT1	7.32e-06	193	62	5	a594f89a18273797506287d9e22f72abe53e4920
ToppCell	VE-CD8-memory_CD4\|VE / Condition, Cell_class and T cell subcluster	CCR2 COL4A3 GZMM CCSER2	6.00e-05	152	62	4	9401b7770c1bdc87eba25e82922f5dd1c4fa37ee
ToppCell	normal-na-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	COL16A1 GZMM CCSER2 ADAT1	6.47e-05	155	62	4	08295584395e8d9cfc1b1648f98754b3ac53e587
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CCR2 ASF1B FIGNL1 ADAT1	6.63e-05	156	62	4	33deda19f06172079ef1dd49fd54d66da1e7fb14
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell-D231\|Adult / Lineage, Cell type, age group and donor	COL4A6 FLNC COL16A1 SORBS1	7.32e-05	160	62	4	d783d29150033e9181c0e30870070268fed3fd85
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL4A6 IRS1 ZBTB12 ADAMTS5	8.05e-05	164	62	4	e3983f655cdba308fb192182829f17bef99ce0ba
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|Fibroblasts / Location, Cell class and cell subclass	COL16A1 DSG2 MOV10L1 SLC12A8	8.05e-05	164	62	4	9b4a6007abae992db871d9f6f731d5af724de30d
ToppCell	facs-Marrow-T-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OXT CARD9 ASF1B ZBTB12	9.04e-05	169	62	4	1558606be0a8bcd4fd0ce609701a1411e4ca2f9f
ToppCell	facs-Marrow-T-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OXT CARD9 ASF1B ZBTB12	9.04e-05	169	62	4	1b2354de1ce4080118d9f01e7c5fd6079e705125
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CCR2 DUS2 ZIK1 ASF1B	9.68e-05	172	62	4	ebeda7ef181cac0109be750a98e7589c615d2724
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Stem_cells-ectodermal/neuroectodermal-like_cells\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	COL16A1 CARD9 ASF1B HASPIN	9.90e-05	173	62	4	7e4a2f5f92fbed16406bd097c0119278e4053245
ToppCell	facs-Lung-Endomucin-24m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HAUS6 ZBED4 ASF1B HASPIN	1.01e-04	174	62	4	7565f6d1c743809807d248ab0e098a2474d9c5b9
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A3 DSG2 ADAMTS5 DNAH1	1.08e-04	177	62	4	e8bb4f8ecd5e283efec966b9fc2040a6152d5551
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC12A8 ADAMTS5 TNFAIP6 FIGNL1	1.08e-04	177	62	4	4197cf2b1e743230c821f422836fa5991b155a52
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	COL4A6 IRS1 SORBS1 ADAMTS5	1.08e-04	177	62	4	b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCR2 NIBAN1 SLC12A8 SP140	1.10e-04	178	62	4	ee674e379ee57e40eb2560ff5ed4c13d8db7ed9d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCR2 NIBAN1 SLC12A8 SP140	1.10e-04	178	62	4	6c45bf197d6c1be0ef7d3a644c0062acf1e24e4d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid-macrophage\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCR2 NIBAN1 SLC12A8 SP140	1.10e-04	178	62	4	cd85dcefe94ee742db64b63e105e13532321894a
ToppCell	droplet-Liver-nan-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A3 HAUS6 SETX CASP9	1.18e-04	181	62	4	fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSG2 IRS1 F7 EPHA1	1.20e-04	182	62	4	770ce9f3f4538d0181a0181543841bc964c68274
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSG2 IRS1 F7 EPHA1	1.20e-04	182	62	4	77ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCell	facs-Liver-Hepatocytes-24m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DSG2 IRS1 F7 EPHA1	1.20e-04	182	62	4	4921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Undetermined\|Fibroblasts / Location, Cell class and cell subclass	DUS2 THADA DSG2 ETFDH	1.31e-04	186	62	4	403ac98f72a42721f84fbd7826f251a88ae534a2
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	THADA ZBED4 GZMM SP140	1.42e-04	190	62	4	91ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell	IPF-Lymphoid-T_Cytotoxic\|IPF / Disease state, Lineage and Cell class	NIBAN1 GZMM CCSER2 SP140	1.42e-04	190	62	4	e5d0186bfb416a3eda76ac12b9379650afb6f409
ToppCell	IPF-Lymphoid-T\|IPF / Disease state, Lineage and Cell class	NIBAN1 ZBED4 CCSER2 SP140	1.42e-04	190	62	4	d57df208aaf7a5554899bb9107c80b443fd0cf93
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASF1B GZMM HASPIN FIGNL1	1.42e-04	190	62	4	b99271d139c8d01e20feb95d99f79c9b2756b4cb
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	THADA COL16A1 ADAMTS5 TNFAIP6	1.45e-04	191	62	4	b51e0f5d1b93f526160c904e9091313a5364f3a7
ToppCell	COPD-Lymphoid-T_Cytotoxic\|World / Disease state, Lineage and Cell class	NIBAN1 ZBED4 GZMM CCSER2	1.48e-04	192	62	4	5bfd9f5d47511441eb2d3cc3c4d7ed330ffd0bd1
ToppCell	COPD-Lymphoid-T_Cytotoxic\|COPD / Disease state, Lineage and Cell class	NIBAN1 ZBED4 GZMM CCSER2	1.51e-04	193	62	4	58e94fe2e89cdafc6974938f97a4c162061a437d
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	FLNC COL16A1 ADAMTS5 CSMD3	1.51e-04	193	62	4	cd45118ced91b10baed3b1068d4673ec99824b86
ToppCell	IPF-Lymphoid-T_Cytotoxic\|Lymphoid / Disease state, Lineage and Cell class	NIBAN1 GZMM CCSER2 ADAT1	1.51e-04	193	62	4	3c8a022dbd4f8d25b14fd137ce64c2713a7dbe41
ToppCell	IPF-Lymphoid-T_Cytotoxic\|World / Disease state, Lineage and Cell class	NIBAN1 GZMM CCSER2 SP140	1.51e-04	193	62	4	35c902a983d7f1156a74fe68ee366609029833b3
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_memory_T_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NIBAN1 GZMM CCSER2 ADAT1	1.54e-04	194	62	4	866a9ca4c93c3c79c709a9d00def5392197f7e18
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	COL4A6 IRS1 SORBS1 ADAMTS5	1.57e-04	195	62	4	4dba732c8d8ecf0ed9ece1814dc4060402199ed9
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CCR2 NIBAN1 GZMM SP140	1.57e-04	195	62	4	9b7157b5e4b81bc35b0e6d9b954279160ea57324
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NIBAN1 IQSEC1 TNFAIP6 SP140	1.60e-04	196	62	4	fe8d3f45a64323947c36b127355d5940eb56c0ca
ToppCell	mild-Myeloid-Neutrophils_2\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PARP10 NIBAN1 TNFAIP6 SP140	1.60e-04	196	62	4	ded44b38ea489946e9eedfe752b5a9fde9149c16
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NIBAN1 IQSEC1 TNFAIP6 SP140	1.60e-04	196	62	4	526d037bb12d81f1c235c60ddc787fbad0bbad77
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NIBAN1 IQSEC1 TNFAIP6 SP140	1.63e-04	197	62	4	3cd1c816bc7a57278b2ef615b69545356ab8f522
ToppCell	367C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	COL16A1 SLC12A8 TNFAIP6 TTC3	1.66e-04	198	62	4	c55608633f66e3d434c5d81324efb07c5120d2c2
ToppCell	367C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	COL16A1 SLC12A8 TNFAIP6 TTC3	1.66e-04	198	62	4	3e5459038fc6ed95f529eb4d1dc5113e16c19012
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-B_(Myofibroblast)\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	COL16A1 SLC12A8 TTC3 HR	1.66e-04	198	62	4	196257c4420ac801ed9fbb444f11718adb7560ae
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CCR2 COL4A6 NIBAN1 SORBS1	1.66e-04	198	62	4	d1827e3707b929e3a3562989a0c11537d344e164
ToppCell	distal-mesenchymal-Fibromyocyte-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL4A6 COL16A1 IRS1 ADAMTS5	1.66e-04	198	62	4	9d1d95e7703cfc70a8ad427e400c340dbd205db8
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL4A6 FLNC COL16A1 SORBS1	1.66e-04	198	62	4	e9f434bfd072e590fe44d518057ee5aa653038f3
ToppCell	distal-mesenchymal-Fibromyocyte\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	COL4A6 COL16A1 IRS1 ADAMTS5	1.66e-04	198	62	4	fbfac1d10e4224990a094cc84b74bbc206881423
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	COL4A6 IRS1 SORBS1 ADAMTS5	1.69e-04	199	62	4	a207b4891881149d4c50721310690fd794157723
ToppCell	(02)_MMP9/10+-(2)_GFP_FOXI1\|(02)_MMP9/10+ / shred by cell type by condition	CCSER2 IRS1 ADAMTS5 TTC3	1.69e-04	199	62	4	18a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell	mLN-(1)_T_cell-(10)_CD8_T\|mLN / shred on region, Cell_type, and subtype	NIBAN1 GZMM CCSER2 ADAT1	1.73e-04	200	62	4	6f02ba3a76e8aa3083efea9cb4ee587799c61fda
ToppCell	mLN-T_cell-CD8_T\|mLN / Region, Cell class and subclass	NIBAN1 GZMM CCSER2 ADAT1	1.73e-04	200	62	4	a221213f9245297a5d6196564c1043f8c17eb857
ToppCell	Biopsy_IPF-Mesenchymal-HAS1_High_Fibroblasts\|Biopsy_IPF / Sample group, Lineage and Cell type	FLNC SLC12A8 ADAMTS5 TNFAIP6	1.73e-04	200	62	4	d02e256b5d65a5c982ba5696bc7e077281ca3e24
Drug	GK-101	COL4A3 COL4A6 COL16A1 COL22A1	2.75e-06	36	62	4	CID000161853
Drug	candesartan cilexetil	COL4A3 COL4A6 COL16A1 MOV10L1 COL22A1 NOS3	2.76e-06	145	62	6	CID000002540
Drug	Madecassol	COL4A3 COL4A6 COL16A1 COL22A1	7.47e-06	46	62	4	CID000108062
Drug	losartan	COL4A3 COL4A6 COL16A1 OXT MOV10L1 IRS1 COL22A1 NOS3	8.29e-06	378	62	8	CID000003961
Drug	d-indobufen	COL4A3 COL4A6 COL16A1 COL22A1	1.05e-05	50	62	4	CID000044562
Drug	hydroxylysine	COL4A3 COL4A6 COL16A1 ETFDH COL22A1	1.19e-05	109	62	5	CID000001029
Drug	ridogrel	COL4A3 COL4A6 COL16A1 COL22A1	1.22e-05	52	62	4	CID005362391
Drug	NSC49633	COL4A3 COL4A6 COL16A1 COL22A1	1.32e-05	53	62	4	CID000023340
Drug	Deptropine citrate [2169-75-7]; Up 200; 7.6uM; MCF7; HT_HG-U133A	COL4A3 ZBED4 CARD9 SLC12A8 ADAMTS5 EPHA1	1.69e-05	199	62	6	5543_UP
Drug	Selara	COL4A3 COL4A6 COL16A1 COL22A1 NOS3	2.32e-05	125	62	5	CID000150310
Drug	AC1LAKND	COL4A3 COL4A6 COL16A1 COL22A1	2.47e-05	62	62	4	CID000470146
Drug	Y-27632	COL4A3 COL4A6 COL16A1 OXT IRS1 COL22A1 NOS3 EPHA1	2.64e-05	444	62	8	CID000005711
Drug	MRK 003	CCR2 FLNC NIBAN1 ZIK1 COL16A1 DSG2 SORBS1 CBX4 TNFAIP6 F7	3.62e-05	760	62	10	ctd:C523799
Drug	PCR 4099	COL4A3 COL4A6 COL16A1 COL22A1 F7	3.86e-05	139	62	5	CID000002806
Drug	geranylgeranyl pyrophosphate	ACLY RAB1C CASP9 RAB1B NOS3	3.86e-05	139	62	5	CID000000735
Drug	BAPN	COL4A3 COL4A6 COL16A1 COL22A1	4.22e-05	71	62	4	CID000001647
Drug	malotilate	COL4A3 COL4A6 COL16A1 COL22A1	4.22e-05	71	62	4	CID000004006
Drug	troglitazone	NIBAN1 ACAD8 LONP2 ACLY ETFDH HASPIN CASP9 SLC12A8 IRS1 SORBS1 CBX4 TNFAIP6 NOS3	4.89e-05	1329	62	13	ctd:C057693
Drug	AC1NMZ1B	COL4A3 COL4A6 COL16A1 COL22A1	5.24e-05	75	62	4	CID005034185
Drug	strontium ranelate	COL4A3 COL4A6 COL16A1 COL22A1	5.81e-05	77	62	4	CID006918182
Drug	LMWH	COL4A3 COL4A6 COL16A1 OXT ACLY COL22A1 TNFAIP6 F7 NOS3	7.29e-05	663	62	9	CID000000772
Drug	L-lysyl-L-lysyl-L-lysine	COL4A3 COL4A6 COL16A1 COL22A1 EPHA1	8.00e-05	162	62	5	CID000072363
Drug	hyaluronan	COL4A3 COL4A6 COL16A1 COL22A1 TNFAIP6 EPHA1	8.02e-05	263	62	6	CID000024759
Drug	halofuginone lactate	COL4A3 COL4A6 COL16A1 COL22A1	8.56e-05	85	62	4	CID000062891
Drug	High Fructose Corn Syrup	IRS1 NOS3	1.09e-04	6	62	2	ctd:D066248
Drug	4-hydroxyproline	COL4A3 COL4A6 COL16A1 COL22A1	1.12e-04	91	62	4	CID000000825
Drug	silibinin	COL4A3 COL4A6 COL16A1 CASP9 IRS1 COL22A1	1.25e-04	285	62	6	CID000005213
Drug	AC1L1DD6	COL4A3 COL4A6 COL16A1 COL22A1 ADAMTS5	1.28e-04	179	62	5	CID000002299
Disease	coronary artery disease (is_implicated_in)	CCR2 IRS1 F7 NOS3	5.59e-05	100	61	4	DOID:3393 (is_implicated_in)
Disease	Disseminated Intravascular Coagulation	OXT F7	8.77e-05	7	61	2	C0012739
Disease	Colorectal Carcinoma	COL4A6 FLNC ATAD1 ETFDH HTR3C CSMD3 EPHA1 HR	9.55e-05	702	61	8	C0009402
Disease	myopathy (implicated_via_orthology)	COL4A3 COL4A6 FLNC	1.36e-04	48	61	3	DOID:423 (implicated_via_orthology)
Disease	collagen disease (implicated_via_orthology)	COL4A3 COL4A6	2.74e-04	12	61	2	DOID:854 (implicated_via_orthology)
Disease	liver cirrhosis (implicated_via_orthology)	FOCAD NOS3	3.23e-04	13	61	2	DOID:5082 (implicated_via_orthology)
Disease	type 2 diabetes mellitus (is_implicated_in)	CASP9 IRS1 SORBS1 F7	4.39e-04	171	61	4	DOID:9352 (is_implicated_in)
Disease	dual specificity mitogen-activated protein kinase kinase 2 measurement	CUL4A FAM181A	4.95e-04	16	61	2	EFO_0008112
Disease	Lipidemias	IRS1 NOS3	5.60e-04	17	61	2	C1706412
Disease	Hyperlipidemia	IRS1 NOS3	5.60e-04	17	61	2	C0020473
Disease	protein Z-dependent protease inhibitor measurement	CUL4A FAM181A	6.30e-04	18	61	2	EFO_0021849
Disease	familial hyperlipidemia (biomarker_via_orthology)	F7 NOS3	7.03e-04	19	61	2	DOID:1168 (biomarker_via_orthology)
Disease	osteoarthritis (biomarker_via_orthology)	CASP9 ADAMTS5	8.61e-04	21	61	2	DOID:8398 (biomarker_via_orthology)
Disease	dilated cardiomyopathy (biomarker_via_orthology)	DSG2 CASP9	9.46e-04	22	61	2	DOID:12930 (biomarker_via_orthology)
Disease	myocardial infarction (is_implicated_in)	CCR2 F7 NOS3	1.14e-03	99	61	3	DOID:5844 (is_implicated_in)
Disease	hypertension (biomarker_via_orthology)	OXT CASP9 F7 NOS3	1.26e-03	227	61	4	DOID:10763 (biomarker_via_orthology)
Disease	Edema	OXT CASP9	1.32e-03	26	61	2	C0013604
Disease	Endogenous Hyperinsulinism	IRS1 NOS3	1.32e-03	26	61	2	C1257963
Disease	Exogenous Hyperinsulinism	IRS1 NOS3	1.32e-03	26	61	2	C1257964
Disease	Compensatory Hyperinsulinemia	IRS1 NOS3	1.32e-03	26	61	2	C1257965
Disease	Anasarca	OXT CASP9	1.32e-03	26	61	2	C0151603
Disease	retinal degeneration (biomarker_via_orthology)	CARD9 NOS3	1.53e-03	28	61	2	DOID:8466 (biomarker_via_orthology)
Disease	Ischemia	OXT NOS3	1.53e-03	28	61	2	C0022116
Disease	Hyperinsulinism	IRS1 NOS3	1.53e-03	28	61	2	C0020459
Disease	colorectal cancer (implicated_via_orthology)	RAB1C RAB1B	1.76e-03	30	61	2	DOID:9256 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
CKSFPGGAGPLGCKE	EPHA1	106	P21709
KGLPGNPGLVGLKGS	COL4A6	866	Q14031
VAGLPALSGPKGEKG	COL4A6	886	Q14031
CGDPGIPAQGKREGK	CSMD3	3291	Q7Z407
IPGAAGLKGQKGAPA	COL4A3	146	Q01955
QGFPGTKGSLGCPGK	COL4A3	711	Q01955
GPKGISCIVVEKGTP	ACAD8	211	Q9UKU7
TKKLPAVEGTPCGKG	ADAMTS5	531	Q9UNA0
RPGEICVIGPKGQKG	COL16A1	421	Q07092
CVIGPKGQKGDPGFV	COL16A1	426	Q07092
APCKGDSGGPLVCGK	GZMM	201	P51124
CPTAPQKGNKGLGLT	HTR3C	361	Q8WXA8
CPCGPSLIRFGGKAK	HCCS	176	P53701
DKGCLAGGGSPKQPF	CARD9	451	Q9H257
ILEPTGKGKPSGCRG	ATXN7L2	586	Q5T6C5
AKCVPGEAGDSGKPG	ADAT1	261	Q9BUB4
LKIDSTPVKPAGGGC	RAB1B	186	Q9H0U4
LKIDSTPVKPAGGGC	RAB1C	186	Q92928
AGVLLAGPPGCGKTL	NVL	616	O15381
AGPPGCGKTLLAKAV	NVL	621	O15381
HCGKGAKGFTPIPGT	DSG2	636	Q14126
GPPGTGKTLIGKCIA	FIGNL1	441	Q6PIW4
LCFVGPPGVGKTSVG	LONP2	371	Q86WA8
PPGGKTFIVVICDGK	MOV10L1	406	Q9BXT6
GKKPIGSLHPGLGCV	IQSEC1	731	Q6DN90
PPTKGGGLGPCGKCQ	HR	331	O43593
DPSKVCAYGPGLKGG	FLNC	1061	Q14315
VDPGKVKCSGPGLGA	FLNC	1441	Q14315
KHVKGILLYGPPGCG	NSF	251	P46459
PPGCGKTLLARQIGK	NSF	261	P46459
ILGLKPSSGGALKPG	MON2	711	Q7Z3U7
LGGAPKEPAKLCGAA	IRS1	1156	P35568
LGLGLCGKQGPATPA	NOS3	21	P29474
AGGKKLALPNGPGVT	CCSER2	296	Q9H7U1
KPVLCIGPTGTGKTL	DNAH1	2221	Q9P2D7
KLTFPGGLLIGCSPG	ETFDH	376	Q16134
GCGLPLNCTPIKGLG	ASF1B	171	Q9NVP2
PAKPGGAGGSKKLVI	CUL4A	31	Q13619
IFNGTSCPSLGGKPK	CASP9	266	P55211
VKPLAGAAGAPGKGS	CBX4	211	O00257
VCGGPGVRPGKNVKV	CCR2	331	P41597
GLPGPLGTKAACGKV	COL22A1	996	Q8NFW1
CKRKLVVGNGPEGPG	HASPIN	271	Q8TF76
LGFEPGPATIACGKI	HAUS6	21	Q7Z4H7
PGDLCKKPFVALGSG	DUS2	471	Q9NX74
ALACLGQGKGPNKTP	SLC12A8	346	A0AV02
DPKGRKVPCVGLSIG	HARS1	371	P12081
QPGLKPGLAGGMLFC	FOCAD	826	Q5VW36
KAGPVSPGCVKLAGQ	PARP10	426	Q53GL7
PGGGGGCKEKVLRNP	FAM181A	151	Q8N9Y4
GVLLFGPPGTGKTLC	PSMC2	211	P35998
AASGLGEKGVPPLLC	THADA	1571	Q6YHU6
ASKPQGRIVGGKVCP	F7	206	P08709
GRIVGGKVCPKGECP	F7	211	P08709
LDVRKCLPCGPGGKG	OXT	36	P01178
AKICLIHGPPGTGKS	SETX	1956	Q7Z333
IGPATVGGIKPGCFK	ACLY	621	P53396
VPGSKVLPGLGEGCK	APOL5	11	Q9BWW9
PKGVLLYGPPGCGKT	ATAD1	126	Q8NBU5
AVRPGGCGKKSPFGG	TNRC18	601	O15417
IVKPGPNCGFGKTGI	TNFAIP6	96	P98066
PGGFSGGNPLKNIKC	ZBTB12	321	Q9Y330
GAAPKCRILPAGGKV	NIBAN1	111	Q9BZQ8
LVFPGGKKPGTITEC	ZIK1	186	Q3SY52
GERGPGGPKISKKSC	SORBS1	1136	Q9BX66
LEKAGGLKPFLLGCP	TTC3	1146	P53804
ACGGGAALGLLPPGK	ZSWIM6	56	Q9HCJ5
KAPLLPVTCGGVKGI	SP140	586	Q13342
LGGTGCSCKPPGKYL	ZBED4	61	O75132
LPQKEPVGCSKGGGP	KIAA1522	796	Q9P206