Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acyltransferase activity	TRIM43B RNF121 TRIML1 ZDHHC9 RNF185 MCM3AP RNF135 RNF213 TRIM43 ZDHHC19 RNF175 HERC1 ZNRF4 EP300	2.99e-09	775	49	14	GO:0016746
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	TRIM43B RNF121 TRIML1 RNF185 RNF135 RNF213 TRIM43 RNF175 HERC1 ZNRF4	1.82e-07	473	49	10	GO:0004842
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	TRIM43B RNF121 TRIML1 RNF185 RNF135 RNF213 TRIM43 RNF175 ZNRF4	2.61e-07	372	49	9	GO:0061630
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	TRIM43B RNF121 TRIML1 RNF185 RNF135 RNF213 TRIM43 RNF175 HERC1 ZNRF4	3.77e-07	512	49	10	GO:0019787
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	TRIM43B RNF121 TRIML1 RNF185 RNF135 RNF213 TRIM43 RNF175 ZNRF4	4.61e-07	398	49	9	GO:0061659
GeneOntologyMolecularFunction	aminoacyltransferase activity	TRIM43B RNF121 TRIML1 RNF185 RNF135 RNF213 TRIM43 RNF175 HERC1 ZNRF4	5.35e-07	532	49	10	GO:0016755
GeneOntologyMolecularFunction	semaphorin receptor activity	PLXNA1 PLXNA2	3.83e-04	12	49	2	GO:0017154
GeneOntologyMolecularFunction	histone H3 acetyltransferase activity	MCM3AP EP300	6.07e-04	15	49	2	GO:0010484
GeneOntologyMolecularFunction	nuclear receptor binding	TGFB1I1 LRP2 EP300 HR	1.14e-03	187	49	4	GO:0016922
GeneOntologyMolecularFunction	protein-cysteine S-palmitoyltransferase activity	ZDHHC9 ZDHHC19	1.85e-03	26	49	2	GO:0019706
GeneOntologyMolecularFunction	protein-cysteine S-acyltransferase activity	ZDHHC9 ZDHHC19	1.85e-03	26	49	2	GO:0019707
GeneOntologyMolecularFunction	S-acyltransferase activity	ZDHHC9 ZDHHC19	2.46e-03	30	49	2	GO:0016417
GeneOntologyMolecularFunction	acyltransferase activity, transferring groups other than amino-acyl groups	ZDHHC9 MCM3AP ZDHHC19 EP300	2.74e-03	238	49	4	GO:0016747
GeneOntologyMolecularFunction	nuclear androgen receptor binding	TGFB1I1 EP300	2.97e-03	33	49	2	GO:0050681
GeneOntologyMolecularFunction	palmitoyltransferase activity	ZDHHC9 ZDHHC19	3.72e-03	37	49	2	GO:0016409
GeneOntologyMolecularFunction	bHLH transcription factor binding	FHL2 EP300	3.72e-03	37	49	2	GO:0043425
GeneOntologyMolecularFunction	histone acetyltransferase activity	MCM3AP EP300	6.97e-03	51	49	2	GO:0004402
Domain	ZF_RING_2	TRIM43B RNF121 TRIML1 RNF185 RNF135 RNF213 TRIM43 RNF175 ZNRF4	5.77e-08	298	48	9	PS50089
Domain	RING	TRIM43B RNF121 TRIML1 RNF185 RNF135 RNF213 TRIM43 RNF175 ZNRF4	7.04e-08	305	48	9	SM00184
Domain	zf-C3HC4	RNF121 TRIML1 RNF185 RNF135 RNF213 TRIM43 RNF175 ZNRF4	9.12e-08	223	48	8	PF00097
Domain	Znf_RING	TRIM43B RNF121 TRIML1 RNF185 RNF135 RNF213 TRIM43 RNF175 ZNRF4	1.24e-07	326	48	9	IPR001841
Domain	EGF	SELL PCSK5 FCGBP TENM1 LRP2 LAMB2 MEGF10 CRB2	1.36e-07	235	48	8	SM00181
Domain	-	TRIM43B RNF121 TRIML1 RNF185 RNF135 AIRE RNF213 TRIM43 RNF175 ZNRF4	1.68e-07	449	48	10	3.30.40.10
Domain	Znf_RING/FYVE/PHD	TRIM43B RNF121 TRIML1 RNF185 RNF135 AIRE RNF213 TRIM43 RNF175 ZNRF4	2.07e-07	459	48	10	IPR013083
Domain	EGF-like_dom	SELL PCSK5 FCGBP TENM1 LRP2 LAMB2 MEGF10 CRB2	2.12e-07	249	48	8	IPR000742
Domain	ZF_RING_1	TRIM43B RNF121 TRIML1 RNF185 RNF135 TRIM43 RNF175 ZNRF4	6.93e-07	291	48	8	PS00518
Domain	LIM	TGFB1I1 TES FHL1 FHL2 FHL3	8.99e-07	69	48	5	PF00412
Domain	-	TGFB1I1 TES FHL1 FHL2 FHL3	9.66e-07	70	48	5	2.10.110.10
Domain	Znf_LIM	TGFB1I1 TES FHL1 FHL2 FHL3	1.04e-06	71	48	5	IPR001781
Domain	LIM_DOMAIN_1	TGFB1I1 TES FHL1 FHL2 FHL3	1.04e-06	71	48	5	PS00478
Domain	LIM_DOMAIN_2	TGFB1I1 TES FHL1 FHL2 FHL3	1.04e-06	71	48	5	PS50023
Domain	LIM	TGFB1I1 TES FHL1 FHL2 FHL3	1.04e-06	71	48	5	SM00132
Domain	SPRY	TRIM43B TRIML1 RNF135 TRIM43 HERC1	2.86e-06	87	48	5	SM00449
Domain	SPRY	TRIM43B TRIML1 RNF135 TRIM43 HERC1	4.19e-06	94	48	5	PF00622
Domain	SPRY_dom	TRIM43B TRIML1 RNF135 TRIM43 HERC1	4.19e-06	94	48	5	IPR003877
Domain	EGF-like_CS	SELL TENM1 LRP2 LAMB2 ZNRF4 MEGF10 CRB2	4.34e-06	261	48	7	IPR013032
Domain	B30.2/SPRY	TRIM43B TRIML1 RNF135 TRIM43 HERC1	4.41e-06	95	48	5	IPR001870
Domain	B302_SPRY	TRIM43B TRIML1 RNF135 TRIM43 HERC1	4.41e-06	95	48	5	PS50188
Domain	ConA-like_dom	TRIM43B TRIML1 RNF135 TRIM43 HERC1 CRB2	1.97e-05	219	48	6	IPR013320
Domain	Butyrophylin	TRIM43B TRIML1 RNF135 TRIM43	3.11e-05	70	48	4	IPR003879
Domain	EGF_1	SELL TENM1 LRP2 LAMB2 MEGF10 CRB2	4.64e-05	255	48	6	PS00022
Domain	EGF_2	SELL TENM1 LRP2 LAMB2 MEGF10 CRB2	5.74e-05	265	48	6	PS01186
Domain	Znf_RING_CS	TRIM43B TRIML1 RNF185 RNF135 TRIM43	6.02e-05	163	48	5	IPR017907
Domain	Znf_C3HC4_RING-type	TRIML1 RNF185 RNF135 RNF213 ZNRF4	7.77e-05	172	48	5	IPR018957
Domain	Plexin_cytopl	PLXNA1 PLXNA2	2.30e-04	9	48	2	PF08337
Domain	Plexin_cytoplasmic_RasGAP_dom	PLXNA1 PLXNA2	2.30e-04	9	48	2	IPR013548
Domain	Plexin	PLXNA1 PLXNA2	2.30e-04	9	48	2	IPR031148
Domain	EGF_3	SELL TENM1 LRP2 MEGF10 CRB2	3.33e-04	235	48	5	PS50026
Domain	EGF_extracell	TENM1 LRP2 MEGF10	4.92e-04	60	48	3	IPR013111
Domain	EGF_2	TENM1 LRP2 MEGF10	4.92e-04	60	48	3	PF07974
Domain	PLAC	PCSK5 ADAMTSL3	5.77e-04	14	48	2	PF08686
Domain	TIL_dom	FCGBP LRP2	5.77e-04	14	48	2	IPR002919
Domain	PLAC	PCSK5 ADAMTSL3	1.08e-03	19	48	2	PS50900
Domain	PLAC	PCSK5 ADAMTSL3	1.08e-03	19	48	2	IPR010909
Domain	zf-DHHC	ZDHHC9 ZDHHC19	1.58e-03	23	48	2	PF01529
Domain	DHHC	ZDHHC9 ZDHHC19	1.87e-03	25	48	2	PS50216
Domain	Znf_DHHC_palmitoyltrfase	ZDHHC9 ZDHHC19	1.87e-03	25	48	2	IPR001594
Domain	IPT	PLXNA1 PLXNA2	2.18e-03	27	48	2	SM00429
Domain	hEGF	MEGF10 CRB2	2.34e-03	28	48	2	PF12661
Domain	TIG	PLXNA1 PLXNA2	2.87e-03	31	48	2	PF01833
Domain	Sema	PLXNA1 PLXNA2	2.87e-03	31	48	2	SM00630
Domain	Semap_dom	PLXNA1 PLXNA2	2.87e-03	31	48	2	IPR001627
Domain	Sema	PLXNA1 PLXNA2	2.87e-03	31	48	2	PF01403
Domain	SEMA	PLXNA1 PLXNA2	2.87e-03	31	48	2	PS51004
Domain	PSI	PLXNA1 PLXNA2	3.05e-03	32	48	2	PF01437
Domain	IPT	PLXNA1 PLXNA2	3.05e-03	32	48	2	IPR002909
Domain	Plexin_repeat	PLXNA1 PLXNA2	3.05e-03	32	48	2	IPR002165
Domain	Laminin_EGF	LAMB2 MEGF10	3.65e-03	35	48	2	PF00053
Domain	EGF_Lam	LAMB2 MEGF10	3.65e-03	35	48	2	SM00180
Domain	EGF	SELL LRP2 CRB2	4.16e-03	126	48	3	PF00008
Domain	Laminin_EGF	LAMB2 MEGF10	4.29e-03	38	48	2	IPR002049
Domain	-	TENM1 LRP2	4.51e-03	39	48	2	2.120.10.30
Pathway	REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION	PLXNA1 PLXNA2	1.17e-04	9	26	2	MM15030
Pathway	REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION	PLXNA1 PLXNA2	2.94e-04	14	26	2	MM15029
Pathway	REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION	PLXNA1 PLXNA2	2.94e-04	14	26	2	M7578
Pathway	REACTOME_CRMPS_IN_SEMA3A_SIGNALING	PLXNA1 PLXNA2	3.38e-04	15	26	2	MM15031
Pathway	REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY	RNF135 EP300	3.38e-04	15	26	2	M953
Pathway	REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION	PLXNA1 PLXNA2	3.86e-04	16	26	2	M16498
Pathway	REACTOME_CRMPS_IN_SEMA3A_SIGNALING	PLXNA1 PLXNA2	3.86e-04	16	26	2	M8245
Pathway	REACTOME_OTHER_SEMAPHORIN_INTERACTIONS	PLXNA1 PLXNA2	5.49e-04	19	26	2	M10959
Pathway	WP_ANDROGEN_RECEPTOR_SIGNALING	TGFB1I1 FHL2 EP300	6.08e-04	91	26	3	M39700
Pathway	BIOCARTA_P53HYPOXIA_PATHWAY	FHL2 EP300	6.72e-04	21	26	2	M5202
Pathway	PID_HDAC_CLASSIII_PATHWAY	FHL2 EP300	1.03e-03	26	26	2	M32
Pubmed	Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1.	FHL1 FHL2 FHL3 EP300	6.14e-11	6	51	4	22219185
Pubmed	Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular system.	FHL1 FHL2 FHL3	2.97e-09	3	51	3	10906474
Pubmed	Slim defines a novel family of LIM-proteins expressed in skeletal muscle.	FHL1 FHL2 FHL3	2.97e-09	3	51	3	8753811
Pubmed	The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle.	FHL1 FHL2 FHL3	2.97e-09	3	51	3	10049693
Pubmed	Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly.	FHL1 FHL2 FHL3	1.19e-08	4	51	3	16407297
Pubmed	FHL family members suppress vascular endothelial growth factor expression through blockade of dimerization of HIF1α and HIF1β.	FHL1 FHL2 FHL3	2.96e-08	5	51	3	23086815
Pubmed	A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM.	FHL1 FHL2 FHL3	5.92e-08	6	51	3	11046156
Pubmed	Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway.	FHL1 FHL2 FHL3	1.65e-07	8	51	3	19139564
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PCSK5 TMEM94 MCM3AP THAP8 LAMB2 HERC1 DHX34 EP300 PLXNA1 PPP1R16A HR	4.71e-07	1105	51	11	35748872
Pubmed	The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF.	FHL1 FHL2 FHL3	1.07e-06	14	51	3	15610731
Pubmed	A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity.	FHL1 FHL2 FHL3	1.33e-06	15	51	3	28094252
Pubmed	Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A.	PLXNA1 PLXNA2	2.11e-06	2	51	2	10781943
Pubmed	Protein-protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two-fusion fluorescence resonance energy transfer (FRET).	FHL2 FHL3	2.11e-06	2	51	2	11135358
Pubmed	Four-and-a-half LIM domains proteins are novel regulators of the protein kinase D pathway in cardiac myocytes.	FHL1 FHL2	2.11e-06	2	51	2	24219103
Pubmed	Structural Basis for Plexin Activation and Regulation.	PLXNA1 PLXNA2	6.32e-06	3	51	2	27397516
Pubmed	Identification of plexin family molecules in mice.	PLXNA1 PLXNA2	6.32e-06	3	51	2	8806646
Pubmed	Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes.	FHL2 FHL3	6.32e-06	3	51	2	14729955
Pubmed	Fyn-dependent phosphorylation of PlexinA1 and PlexinA2 at conserved tyrosines is essential for zebrafish eye development.	PLXNA1 PLXNA2	6.32e-06	3	51	2	29091353
Pubmed	Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells.	PLXNA1 PLXNA2	6.32e-06	3	51	2	18625214
Pubmed	Plexins promote Hedgehog signaling through their cytoplasmic GAP activity.	PLXNA1 PLXNA2	6.32e-06	3	51	2	36169302
Pubmed	Differential expression of plexin-A subfamily members in the mouse nervous system.	PLXNA1 PLXNA2	6.32e-06	3	51	2	11241833
Pubmed	A LIM protein, Hic-5, functions as a potential coactivator for Sp1.	TGFB1I1 EP300	6.32e-06	3	51	2	14755691
Pubmed	The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor.	FHL2 FHL3	1.26e-05	4	51	2	15117962
Pubmed	Upregulation of FHL1, SPNS3, and MPZL2 predicts poor prognosis in pediatric acute myeloid leukemia patients with FLT3-ITD mutation.	FHL1 FHL3	1.26e-05	4	51	2	35249471
Pubmed	Determination of cell adhesion sites of neuropilin-1.	PLXNA1 PLXNA2	1.26e-05	4	51	2	10725340
Pubmed	P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain.	AIRE EP300	1.26e-05	4	51	2	12929931
Pubmed	How defects in central tolerance impinge on a deficiency in regulatory T cells.	SELL AIRE	1.26e-05	4	51	2	16203996
Pubmed	Chromosome assignment of four plexin A genes (Plxna1, Plxna2, Plxna3, Plxna4) in mouse, rat, Syrian hamster and Chinese hamster.	PLXNA1 PLXNA2	1.26e-05	4	51	2	11306810
Pubmed	Testin and filamin-C downregulation by acetylated Siah2 increases invasiveness of Helicobacter pylori-infected gastric cancer cells.	TES EP300	1.26e-05	4	51	2	30063986
Pubmed	PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.	PLXNA1 PLXNA2	1.26e-05	4	51	2	25518740
Pubmed	A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.	PLXNA1 PLXNA2	1.26e-05	4	51	2	8570614
Pubmed	FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1.	FHL2 FHL3	1.26e-05	4	51	2	15453830
Pubmed	The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein.	FHL2 FHL3	2.10e-05	5	51	2	12145280
Pubmed	Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells.	PLXNA1 PLXNA2	2.10e-05	5	51	2	25313870
Pubmed	Interaction and functional cooperation between the LIM protein FHL2, CBP/p300, and beta-catenin.	FHL2 EP300	2.10e-05	5	51	2	15572674
Pubmed	Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2.	FHL1 FHL2	3.15e-05	6	51	2	12432079
Pubmed	Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages.	PLXNA1 PLXNA2	3.15e-05	6	51	2	19480842
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	TGFB1I1 AIRE FHL1 FHL2 FHL3	4.21e-05	263	51	5	20932939
Pubmed	Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points.	PLXNA1 PLXNA2	4.41e-05	7	51	2	19063725
Pubmed	Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.	PLXNA1 PLXNA2	4.41e-05	7	51	2	19655386
Pubmed	Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors.	PLXNA1 PLXNA2	4.41e-05	7	51	2	10520994
Pubmed	The expression of plexins during mouse embryogenesis.	PLXNA1 PLXNA2	5.87e-05	8	51	2	15661641
Pubmed	Linkage of genes for laminin B1 and B2 subunits on chromosome 1 in mouse.	SELL LAMB2	5.87e-05	8	51	2	2993224
Pubmed	Integration of opposing semaphorin guidance cues in cortical axons.	PLXNA1 PLXNA2	5.87e-05	8	51	2	22368082
Pubmed	Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.	TGFB1I1 TES FHL1 FHL2 FHL3	6.16e-05	285	51	5	21423176
Pubmed	PlexinA2 and semaphorin signaling during cardiac neural crest development.	PLXNA1 PLXNA2	7.54e-05	9	51	2	11688557
Pubmed	The role of neuropilins in cell signalling.	PLXNA1 PLXNA2	7.54e-05	9	51	2	19909241
Pubmed	Semaphorin 6A in Retinal Ganglion Cells Regulates Functional Specialization of the Inner Retina.	PLXNA2 MEGF10	7.54e-05	9	51	2	38014224
Pubmed	Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development.	PLXNA1 PLXNA2	9.42e-05	10	51	2	18804103
Pubmed	Human ALKBH4 interacts with proteins associated with transcription.	TES EP300	9.42e-05	10	51	2	23145062
Pubmed	Class 3 semaphorins negatively regulate dermal lymphatic network formation.	PLXNA1 PLXNA2	1.15e-04	11	51	2	26319580
Pubmed	Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability.	PLXNA1 PLXNA2	1.38e-04	12	51	2	25839327
Pubmed	PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons.	PLXNA1 PLXNA2	1.38e-04	12	51	2	31690636
Pubmed	On and off retinal circuit assembly by divergent molecular mechanisms.	PLXNA1 PLXNA2	1.38e-04	12	51	2	24179230
Pubmed	Transcriptome profiling reveals expression signatures of cranial neural crest cells arising from different axial levels.	PLXNA1 PLXNA2	1.38e-04	12	51	2	28407732
Pubmed	Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.	PLXNA1 PLXNA2	1.38e-04	12	51	2	21270798
Pubmed	Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons.	PLXNA1 PLXNA2	1.38e-04	12	51	2	23991118
Pubmed	Plexin signaling via off-track and rho family GTPases.	PLXNA1 PLXNA2	1.63e-04	13	51	2	11604131
Pubmed	Functional assembly of accessory optic system circuitry critical for compensatory eye movements.	PLXNA1 PLXNA2	1.63e-04	13	51	2	25959730
Pubmed	Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.	PLXNA1 PLXNA2	1.63e-04	13	51	2	10520995
Pubmed	Semaphorin3A, Neuropilin-1, and PlexinA1 are required for lymphatic valve formation.	PLXNA1 PLXNA2	1.63e-04	13	51	2	22723296
Pubmed	A midline switch of receptor processing regulates commissural axon guidance in vertebrates.	PLXNA1 PLXNA2	1.90e-04	14	51	2	20159958
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TRIML1 TES MCM3AP LRP2 RNF213 FHL3 DHX34 EP300	2.05e-04	1116	51	8	31753913
Pubmed	Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.	TRIM43B TRIM43	2.19e-04	15	51	2	19703589
Pubmed	Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus.	PLXNA1 PLXNA2	2.50e-04	16	51	2	18489001
Pubmed	Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1.	PLXNA1 PLXNA2	2.50e-04	16	51	2	17356169
Pubmed	Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing.	PLXNA1 PLXNA2	2.50e-04	16	51	2	22632726
Pubmed	Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.	PLXNA1 PLXNA2	2.83e-04	17	51	2	11683995
Pubmed	Semaphorin signaling facilitates cleft formation in the developing salivary gland.	PLXNA1 PLXNA2	2.83e-04	17	51	2	17626059
Pubmed	Genetic analysis of anterior posterior expression gradients in the developing mammalian forebrain.	FHL1 FHL2	3.18e-04	18	51	2	17150988
Pubmed	The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.	RNF135 ADAMTSL3 SLC23A3	3.29e-04	91	51	3	20546612
Pubmed	A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.	TENM1 PLXNA1 PLXNA2	3.29e-04	91	51	3	28558017
Pubmed	Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins.	FHL1 FHL2	3.55e-04	19	51	2	27171814
Pubmed	PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development.	PLXNA1 PLXNA2	3.55e-04	19	51	2	15239958
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	RNF121 PCSK5 TMEM94 TENM1 LAMB2 DHX34 EP300 PPP1R16A	3.63e-04	1215	51	8	15146197
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	RNF185 RNF213 HERC1	3.74e-04	95	51	3	29643511
Pubmed	Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins.	ZDHHC9 ZDHHC19	3.94e-04	20	51	2	16647879
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	TGFB1I1 TES FHL2 FHL3	3.96e-04	235	51	4	28378594
Pubmed	Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function.	PLXNA1 PLXNA2	4.35e-04	21	51	2	21835343
Pubmed	Negative modulation of androgen receptor transcriptional activity by Daxx.	TGFB1I1 FHL2	4.78e-04	22	51	2	15572661
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	MCM3AP RNF213 EP300	4.87e-04	104	51	3	31240132
Pubmed	Zic2-dependent axon midline avoidance controls the formation of major ipsilateral tracts in the CNS.	PLXNA1 PLXNA2	5.23e-04	23	51	2	24360543
Pubmed	Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.	LRP2 GALNT12	5.70e-04	24	51	2	31740596
Pubmed	A semaphorin code defines subpopulations of spinal motor neurons during mouse development.	PLXNA1 PLXNA2	5.70e-04	24	51	2	15869472
Pubmed	A radial axis defined by semaphorin-to-neuropilin signaling controls pancreatic islet morphogenesis.	PLXNA1 PLXNA2	5.70e-04	24	51	2	28893946
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	TES FHL1 FHL2 FHL3 PLXNA1 PLXNA2	5.80e-04	709	51	6	22988430
Pubmed	The structural role of radial glial endfeet in confining spinal motor neuron somata is controlled by the Reelin and Notch pathways.	PLXNA1 PLXNA2	6.70e-04	26	51	2	23988635
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	TGFB1I1 TRIM43B MCM3AP LRP2 RNF213 MEGF10	7.05e-04	736	51	6	29676528
Pubmed	Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2.	FHL1 FHL2	7.23e-04	27	51	2	36899856
Pubmed	Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube.	PLXNA1 PLXNA2	7.23e-04	27	51	2	25843547
Pubmed	Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.	PLXNA1 PLXNA2	7.78e-04	28	51	2	18617019
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	MCM3AP PLXNA2 MEGF10	9.32e-04	130	51	3	12421765
Pubmed	Large-scale analysis of the human ubiquitin-related proteome.	RNF213 FHL1 FHL2 FHL3	1.15e-03	313	51	4	16196087
Pubmed	Many sequence variants affecting diversity of adult human height.	RNF135 ADAMTSL3 SLC23A3	1.23e-03	143	51	3	18391951
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	TGFB1I1 LAMB2 FHL2 FHL3 MEGF10	1.36e-03	560	51	5	21653829
Pubmed	EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.	RNF121 HERC1 EP300	1.41e-03	150	51	3	32423001
Interaction	UBE2D2 interactions	RNF185 RNF135 THAP8 RNF213 TRIM43 HERC1 ZNRF4	1.11e-05	318	49	7	int:UBE2D2
Interaction	GPHA2 interactions	PCSK5 LAMB2 PLXNA2	2.99e-05	25	49	3	int:GPHA2
Interaction	IGFL3 interactions	PCSK5 LRP2 LAMB2 PLXNA2	3.30e-05	75	49	4	int:IGFL3
Interaction	PI15 interactions	PCSK5 LAMB2 GALNT12 PLXNA1	4.92e-05	83	49	4	int:PI15
Cytoband	2q11.1	TRIM43B TRIM43	4.49e-04	28	51	2	2q11.1
GeneFamily	Ring finger proteins	TRIM43B RNF121 TRIML1 RNF185 RNF135 RNF213 TRIM43 RNF175 ZNRF4	4.24e-09	275	38	9	58
GeneFamily	LIM domain containing	TGFB1I1 TES FHL1 FHL2 FHL3	1.44e-07	59	38	5	1218
GeneFamily	Plexins	PLXNA1 PLXNA2	1.53e-04	9	38	2	683
GeneFamily	Zinc fingers DHHC-type\|Ankyrin repeat domain containing	ZDHHC9 ZDHHC19	1.15e-03	24	38	2	76
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TGFB1I1 PCSK5 FHL1 FHL2 ADAMTSL3 PRIMA1	1.06e-07	199	51	6	6b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 TES FHL1 FHL2 FHL3	2.07e-06	182	51	5	728a2152c166551ac229370c0900fe2bc426ea9b
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-ACTC+_SMC\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TGFB1I1 TES TENM1 FHL1 FHL2	2.18e-06	184	51	5	39168ca2bbf1369c9fe87c67f0aaff5e3cd03151
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	TGFB1I1 PCSK5 FHL2 FHL3 PLXNA2	2.36e-06	187	51	5	387cb27c8a20031cd87381a9e1172f1f62e1488b
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 TES FHL1 FHL2 FHL3	2.69e-06	192	51	5	d0fb6885f023d55a2b7984c99db9c6463258f788
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-myocytic\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 TES FHL2 FHL3 PLXNA2	2.83e-06	194	51	5	15060cc25baf49dd04d9c20499e28718610ef754
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 TES FHL2 FHL3 PLXNA2	2.83e-06	194	51	5	12a2c60303607b8b5812405ad216d0612c56c64b
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	TGFB1I1 PCSK5 FHL1 FHL2 PRIMA1	2.90e-06	195	51	5	4dba732c8d8ecf0ed9ece1814dc4060402199ed9
ToppCell	E17.5-Mesenchymal-myocytic_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TGFB1I1 PCSK5 FHL2 PLXNA2 MEGF10	2.90e-06	195	51	5	01a750d660993017af00736215cbcff2de5909c1
ToppCell	E17.5-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TGFB1I1 PCSK5 FHL2 PLXNA2 MEGF10	2.90e-06	195	51	5	1daddd801bd4596fffbdb822fc326d5127c96004
ToppCell	11.5-Distal-Mesenchymal-Airway_Smooth_Muscle\|Distal / Age, Tissue, Lineage and Cell class	TGFB1I1 PCSK5 FHL2 FHL3 PLXNA2	2.98e-06	196	51	5	05530fe7a5681c2f39b95016cd22ef99d6ac0430
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 FHL2 FHL3 PLXNA2 CRB2	3.05e-06	197	51	5	c7b33d64e5cba3a8fc6f2d6aa85ebc83893195de
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TGFB1I1 PCSK5 FHL1 FHL2 MEGF10	3.13e-06	198	51	5	63f7d25201613bd3404c28fb936954190bca91d3
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TGFB1I1 PCSK5 FHL1 FHL2 MEGF10	3.13e-06	198	51	5	a73534b6ca202c277a70a52281d5b97a3e6cb8ef
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TGFB1I1 PCSK5 FHL1 FHL2 MEGF10	3.13e-06	198	51	5	d1e1bdd36c84e1bac21ba137f018defe98456a8c
ToppCell	18-Distal-Mesenchymal-Airway_Smooth_Muscle\|Distal / Age, Tissue, Lineage and Cell class	TGFB1I1 PCSK5 FHL1 FHL2 FHL3	3.21e-06	199	51	5	9dd130c041beaa319727f9d22b3f45ba0da49487
ToppCell	MS-CD4-CD8_2\|MS / Condition, Cell_class and T cell subcluster	SELL C5orf34 PNPLA7 PLXNA2	2.56e-05	149	51	4	08fb6be5599c5988890c851ce5ac6781c319948e
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	LRP2 TMEM151A CRB2 SLC23A3	3.06e-05	156	51	4	605d95a900e1443d3f6aae163ef2e893d3293203
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	LRP2 TMEM151A CRB2 SLC23A3	3.06e-05	156	51	4	574f761962a7dd3308bd41fc529dd3ea1b8625f8
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-NK_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELL TES GALNT12 FHL2	3.14e-05	157	51	4	af110085dad5d26b0b7068a78f104ba784fa8564
ToppCell	facs-Lung-EPCAM-24m-Lymphocytic-Natural_Killer\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELL TES GALNT12 FHL2	3.14e-05	157	51	4	071f10d749b590b75a07ab3c7b00956dc7cda4da
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK5 FHL1 FHL2 ADAMTSL3	4.09e-05	168	51	4	4b2d29a7843bf45922038c093ca7ec0600756adc
ToppCell	droplet-Lung-21m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SELL TES TMEM151A FHL2	4.38e-05	171	51	4	91f18271e280e64c7a790ca29e453c10510f525a
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 TES ZDHHC19 RNF175	4.38e-05	171	51	4	fe0665c5ca01b0b2cc8f20d64587f0847c3d215c
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Vgll3_(Dentate_hilum?)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FCGBP LRP2 AIRE	4.49e-05	60	51	3	aa75fef294803ec6396c7d2c1f51d52bc4a5b43f
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Vgll3_(Dentate_hilum?)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FCGBP LRP2 AIRE	4.49e-05	60	51	3	069fbabfd0e48e5809ff01a026439fd0bd017779
ToppCell	5'-Adult-Appendix-Mesenchymal-myocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 TENM1 FHL1 PRIMA1	4.58e-05	173	51	4	f8e3dded726bb3a6c24bfedf8c6732bb46262308
ToppCell	E16.5-Epithelial-Epithelial_Airway-Neurosecretory\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FUT9 R3HDML PLXNA1 SLC23A3	4.79e-05	175	51	4	38dec78efc99fe23479cba68cfa441e62bd6a08b
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMEM94 RNF135 MEGF10 SLC23A3	4.79e-05	175	51	4	bb898796662b97f7459b7dda7cecf6a9bde8b055
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	C11orf21 AIRE FHL2 DHX34	5.01e-05	177	51	4	36b5d29caa9cffbc0284f771a4db71aa72171a89
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 TES FHL1 FHL2	5.23e-05	179	51	4	e860dca9b28ac5af61804bfd729cd39257cdb352
ToppCell	P03-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GALNT12 TMEM151A CRB2 SLC23A3	5.35e-05	180	51	4	2ccc77d769d3ffd77ab3af45e4f192785b6db79c
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Mesenchymal_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TES FHL1 FHL2 FHL3	5.46e-05	181	51	4	9b2d207dc9fc2228a1555ed360286bb7c2d988ff
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 TES FHL2 PLXNA2	5.58e-05	182	51	4	37547b36264090b49a193a8ef3a8d88e647f0b79
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 TES FHL1 FHL2	5.58e-05	182	51	4	7b86703559438e2d5ef3dad963ee0d772513f313
ToppCell	E18.5-samps-Mesenchymal-Myofibroblast\|E18.5-samps / Age Group, Lineage, Cell class and subclass	PCSK5 FHL2 PLXNA2 MEGF10	5.70e-05	183	51	4	de08f9ea02b7244d5a8788064631d10f06565337
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	TGFB1I1 FHL2 FHL3 PLXNA2	5.70e-05	183	51	4	e84539978ab4de42e19186aed00f24bb50cbc21f
ToppCell	Control-Epithelial_cells-Airway_mucous\|Control / group, cell type (main and fine annotations)	FCGBP FUT9 MYEOV FHL2	5.70e-05	183	51	4	15d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCell	PBMC-Mild-cDC_9\|Mild / Compartment, Disease Groups and Clusters	TGFB1I1 LAMB2 RNF213 DHX34	5.82e-05	184	51	4	2e0c9a2c40c892a2d435eafb31f1f838de9baf15
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP FUT9 FHL1 FHL2	5.95e-05	185	51	4	fd1911b57927c03470f9387962ca9581e5643fb3
ToppCell	PBMC-Control-Hematopoietic\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TGFB1I1 MYEOV FHL1 FHL2	5.95e-05	185	51	4	c95c77d4302d7fff7fdef1774f15a93ba9ced61a
ToppCell	facs-Large_Intestine-Distal-3m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP FUT9 FHL1 FHL2	5.95e-05	185	51	4	7a18d525de6f874924bfc61b9666b307da86421a
ToppCell	PBMC-Control-Hematopoietic\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	TGFB1I1 MYEOV FHL1 FHL2	5.95e-05	185	51	4	72a281ef246de5b30de1241d792c25bfae60e797
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TGFB1I1 PCSK5 FHL1 PRIMA1	6.07e-05	186	51	4	6add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TGFB1I1 MYEOV FHL1 FHL2	6.07e-05	186	51	4	06281df5e9665ccc510279bf7e552845c63d5dab
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	TGFB1I1 MYEOV FHL1 FHL2	6.07e-05	186	51	4	3bf38c80d892a73391009b426dec8ae26a027351
ToppCell	PBMC-Control-Hematopoietic-Platelet\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	TGFB1I1 MYEOV FHL1 FHL2	6.07e-05	186	51	4	7496137cebc191aecd1e6ae7fa33118b128fbfe6
ToppCell	PBMC-Control-Hematopoietic-Platelet\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TGFB1I1 MYEOV FHL1 FHL2	6.07e-05	186	51	4	9c2fd0bbc968c317a763f52e72fa7182c3c49850
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-large_intestine_goblet_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FCGBP GALNT12 FHL1 FHL2	6.07e-05	186	51	4	32d30f08b20a0a28e38b37bd52ab26d1d43736ce
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZDHHC9 LRP2 MEGF10 PRIMA1	6.20e-05	187	51	4	b71d0cd91bc98e020757c1d071a13ad48d718bcf
ToppCell	primary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ZDHHC9 LRP2 MEGF10 PRIMA1	6.20e-05	187	51	4	f0de86ef25e344d9b1860ee26308877d6c25ed31
ToppCell	Control-Hematopoietic_Mega-Platelet\|Control / Disease group, lineage and cell class	TGFB1I1 MYEOV FHL1 FHL2	6.20e-05	187	51	4	53e9665e1feb02ce8fe78ff4128fd4beacef8471
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 FHL1 FHL2 FHL3	6.20e-05	187	51	4	173f029dcf32af008f517912f6d110a33a9e98cf
ToppCell	Control-Hematopoietic_Mega\|Control / Disease group, lineage and cell class	TGFB1I1 MYEOV FHL1 FHL2	6.20e-05	187	51	4	7bf98bdc83feb3918dbcf12e87a64fe4d2d41eba
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TGFB1I1 PCSK5 FHL3 HR	6.33e-05	188	51	4	c29aaae3c5bb7cd6b9b3defd4d27afde3af19ba0
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	TGFB1I1 TES TENM1 FHL2	6.33e-05	188	51	4	74f7d216209cabdc96b2d46685b0ae017fdcc8fc
ToppCell	Healthy/Control-Platelet\|World / Disease group and Cell class	TGFB1I1 MYEOV FHL1 FHL2	6.33e-05	188	51	4	552077e4597d0956f4d8c40c9de8f109e87cb857
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	TGFB1I1 TENM1 FHL2 PLXNA2	6.46e-05	189	51	4	b6d5dec55bf352f6ae19d8f488ae70aa10fb9a8f
ToppCell	Healthy/Control-Platelet\|Healthy/Control / Disease group and Cell class	TGFB1I1 MYEOV FHL1 FHL2	6.46e-05	189	51	4	3de7f8d8b8451ed9a146cce499552e9a060e9099
ToppCell	Healthy-Platelet\|Healthy / disease group, cell group and cell class	TGFB1I1 MYEOV FHL1 FHL2	6.46e-05	189	51	4	5863e132536594e49bffbb637454cc43dfdbaa20
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	TGFB1I1 PCSK5 FHL2 PLXNA2	6.46e-05	189	51	4	0abc7a4900cc9033bc1be69b770ccc54a6bf41b4
ToppCell	Healthy-Platelet\|World / disease group, cell group and cell class	TGFB1I1 MYEOV FHL1 FHL2	6.46e-05	189	51	4	c3d8e3682cb489bca887039cbea6c4cfc264de2f
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 TES TENM1 FHL2	6.59e-05	190	51	4	e102622f05c7f3e1bd8b224ea159d57033793ee0
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 FHL1 FHL2 FHL3	6.59e-05	190	51	4	c01a8bfb9fbc0e6f37d7e9be25512eda63acabbc
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AIRE FHL2 MEGF10 PRIMA1	6.87e-05	192	51	4	41a8326cd5bc19ad5041068501bab4c72399222e
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_1\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TGFB1I1 PCSK5 FHL2 FHL3	6.87e-05	192	51	4	7ae3e1ca8bfc078c0e12a1595ecb0e343dab5d2f
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AIRE FHL2 MEGF10 PRIMA1	6.87e-05	192	51	4	f88aba74d6e8c594c32fe2bc095b5da28b4b28e9
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 TES FHL2 PLXNA2	7.01e-05	193	51	4	4aa976b596830b585e8d9c808d5072ed23d13a7c
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 TES FHL2 PLXNA2	7.01e-05	193	51	4	5578f7cb3ec68c9a38cc5304b618b81283024d5e
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 TES FHL1 FHL2	7.01e-05	193	51	4	b1893193766ae41bf2ab6ed4083285c9c814e608
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZDHHC9 ZDHHC19 FHL1 PLXNA1	7.01e-05	193	51	4	f492ed02a46f3a45dc6005f9f18ab12a84bfa2a3
ToppCell	ILEUM-inflamed-(8)_Smooth_muscle_cells\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	TGFB1I1 FHL1 FHL2 ADAMTSL3	7.01e-05	193	51	4	084c88f08ce0ecd6c9f4334caed370eb2154f896
ToppCell	E15.5-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TGFB1I1 FHL1 FHL2 MEGF10	7.01e-05	193	51	4	e787e618f6e8a1e22be366ce606bf78831b60a90
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FUT9 LRP2 TMEM151A MEGF10	7.15e-05	194	51	4	cb0422e7607dbd77204428b7e2c70dfe14a6ca11
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 TES FHL1 FHL3	7.15e-05	194	51	4	d2bafd31bb8333f66b6c714944bceb2f1aa11740
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 TES FHL1 FHL2	7.15e-05	194	51	4	bea369e9a7018d862e4d7f1c9ec2de50f3fd38ec
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PCSK5 FHL2 PLXNA2 MEGF10	7.29e-05	195	51	4	b0d408f8bc1701a87596ed55efcd90749fee33e6
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-MYL4+_SMC\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TGFB1I1 TES FHL2 FHL3	7.29e-05	195	51	4	dba2a87efd7e067c094c4b367feb4138cab62735
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PCSK5 FHL2 PLXNA2 MEGF10	7.29e-05	195	51	4	a486a7acea0e91048cc48afa0dbd3926d30bc217
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TGFB1I1 PCSK5 FHL2 PLXNA2	7.29e-05	195	51	4	2414b158dc7bdec43a9671544bfb7ffc5f5168fd
ToppCell	15-Distal-Mesenchymal-Airway_Smooth_Muscle\|Distal / Age, Tissue, Lineage and Cell class	TGFB1I1 PCSK5 FHL2 FHL3	7.44e-05	196	51	4	0e45817625b96d21a8cc4dfbbd465ee6403b6802
ToppCell	Epithelial_cells-AT1_cells\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	TES LAMB2 FHL1 PLXNA1	7.44e-05	196	51	4	6c99d29162848161c1f166a032320f87a5d5a631
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 FHL1 FHL2 FHL3	7.58e-05	197	51	4	398a66c06df63567b176ab2cc85e27837e94d0d9
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 RNF175 FHL2 FHL3	7.58e-05	197	51	4	5f6fce382f273e789ffbb75b63e9b4e87519918e
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 FHL1 FHL2 FHL3	7.58e-05	197	51	4	94a7270ea6d4b586f58875c9e4071ce0f683ef7e
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TGFB1I1 FHL2 FHL3 ADAMTSL3	7.73e-05	198	51	4	637f11e292b90d86cdc0d0d828eb26f38289c25b
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TGFB1I1 FHL1 FHL2 PRIMA1	7.73e-05	198	51	4	2d0c14f8cabab99bc6d7c27685437c78841c7245
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZDHHC9 LRP2 TMEM151A MEGF10	7.89e-05	199	51	4	214a6a267e77e5508867b9eb48c4fbc7855ed0a0
ToppCell	Transverse-(1)_T_cell-(16)_Tfh\|Transverse / shred on region, Cell_type, and subtype	C11orf21 FHL1 ADAMTSL3 PLXNA1	7.89e-05	199	51	4	aa31e26d48066f865ca33251a33a28934c0a7a44
ToppCell	ILEUM-non-inflamed-(8)_Smooth_muscle_cells\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	TGFB1I1 FHL1 FHL2 ADAMTSL3	7.89e-05	199	51	4	3368c0a90a47c4dcdfe70be3192550df0744e508
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	TGFB1I1 PCSK5 LAMB2 FHL1	7.89e-05	199	51	4	e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCell	Control-Control-Others\|Control / Disease, condition lineage and cell class	TGFB1I1 MYEOV FHL1 FHL2	7.89e-05	199	51	4	b7e83772fdd466e1bd0ae13af9ac477e7595ae14
ToppCell	Transverse-T_cell-Tfh\|T_cell / Region, Cell class and subclass	C11orf21 FHL1 ADAMTSL3 PLXNA1	7.89e-05	199	51	4	33ffea12b8228e0b5bd8942531c3b21d24224725
ToppCell	11.5-Airway-Mesenchymal-Airway_Smooth_Muscle\|Airway / Age, Tissue, Lineage and Cell class	TGFB1I1 PCSK5 FHL2 FHL3	7.89e-05	199	51	4	1a8c77d241bd817a195e1532fd25f51358cb1ff1
ToppCell	Transverse-T_cell-Tfh\|Transverse / Region, Cell class and subclass	C11orf21 FHL1 ADAMTSL3 PLXNA1	7.89e-05	199	51	4	cbef8f95edf2e86e16c448a76068d7ed8f6b7748
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	TGFB1I1 PCSK5 LAMB2 FHL1	8.04e-05	200	51	4	593bf6a7c557437db9a9249a5058a46014179ef6
ToppCell	Control-Control-Others-Platelet\|Control / Disease, condition lineage and cell class	TGFB1I1 MYEOV FHL1 FHL2	8.04e-05	200	51	4	e0463c93714ab5fd00f294cca83bd61027fe0e95
ToppCell	Control_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|Control_saline / Treatment groups by lineage, cell group, cell type	TGFB1I1 PCSK5 FHL1 PRIMA1	8.04e-05	200	51	4	c5e051f1aac8dda376c342a9932785a23450e073
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	TGFB1I1 PCSK5 FHL2 ADAMTSL3	8.04e-05	200	51	4	a9ff3210127000b3dd9e97136163c98c2b0817d7
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZDHHC9 LRP2 TMEM151A MEGF10	8.04e-05	200	51	4	acdef0b9096c774040948fc75621ff2b08ea2ee8
Drug	Trichlormethiazide [133-67-5]; Up 200; 10.6uM; MCF7; HT_HG-U133A	TENM1 C11orf21 GALNT12 FHL1 PLXNA2 HR	5.21e-06	198	51	6	4783_UP
Disease	Colorectal Carcinoma	MCM3AP TENM1 LRP2 GALNT12 FHL3 ADAMTSL3 EP300 PRIMA1 HR	1.70e-06	702	48	9	C0009402
Disease	pursuit maintenance gain measurement	PCSK5 C11orf21 FHL2 PLXNA2	4.85e-05	123	48	4	EFO_0008433
Disease	FEV/FEC ratio	PCSK5 C5orf34 FCGBP GALNT12 HERC1 ADAMTSL3 PRIMA1 CRB2	7.53e-04	1228	48	8	EFO_0004713
Disease	proteinuria (implicated_via_orthology)	LAMB2 HR	1.09e-03	30	48	2	DOID:576 (implicated_via_orthology)
Disease	L-Selectin measurement	SELL TENM1	1.17e-03	31	48	2	EFO_0008202

Protein segments in the cluster

Peptide	Gene	Start	Entry
SHWKNCTRHDCPVCL	EP300	401	Q09472
CTHCAAAFHWRCHFP	AIRE	446	O43918
HCRCLPGWSGVHCDS	MEGF10	556	Q96KG7
LPAHSWHCLCALDRC	LPAR2	161	Q9HBW0
VDLWTHFRCDCARPH	CRB2	621	Q5IJ48
LPRFWESHACLACDH	FUT9	326	Q9Y231
WLVSHCPHSLDLCCQ	MCM3AP	1556	O60318
ISGCWCCLHSLCHPS	HERC1	3656	Q15751
GLFNTHWRCPRCSHR	HR	606	O43593
HSRQCHSCRPGWFQL	PCSK5	1531	Q92824
GSRDPHCGWCVLHSI	PLXNA1	526	Q9UIW2
HCGWCVLHSICSRRD	PLXNA1	531	Q9UIW2
PHCGWCALHNMCSRR	PLXNA2	526	O75051
WCHCLRGVSFLTFHL	MYEOV	31	Q96EZ4
LCCDFLAHHGTDCWT	SELL	26	P14151
ACHPCHACFGDWDRV	LAMB2	1186	P55268
RWCHPDCHVEGTCLP	KRTAP1-4	61	P0C5Y4
AHFRCGSGHCIPADW	LRP2	31	P98164
AFTCGHGECIPAHWR	LRP2	1071	P98164
MRSWCSGHLHLCCPR	PNPLA7	871	Q6ZV29
WHDTCFRCAKCLHPL	FHL1	61	Q13642
TWHEHCFLCSGCEQP	FHL3	121	Q13643
WRTDSFCPLHCPAHS	FCGBP	5111	Q9Y6R7
FLDCHCECHEGWLEP	GALNT12	226	Q8IXK2
SWHETCFICHRCQQP	FHL2	121	Q14192
RHSMHPGPWAICCEC	C16orf95	66	Q9H693
HPEGLLWCSRCFFSH	FAM215A	56	Q9Y5M1
SLSCPVPHLHRWNFC	C5orf34	301	Q96MH7
DCLRTFWTCPHCGLH	DHX34	1061	Q14147
HCPWRCDGPTCSHYT	R3HDML	156	Q9H3Y0
CGHSFCRHCLEALWG	RNF135	36	Q8IUD6
GHSFCRPCLCLSWEE	TRIM43	31	Q96BQ3
CEHWVPSCHQHLCSE	THAP8	46	Q8NA92
WHPACFVCSTCHELL	TES	261	Q9UGI8
GCCWSSLLLHCALHP	PRIMA1	11	Q86XR5
ECWTPLHAAATCGHL	PPP1R16A	136	Q96I34
WVGPTCEERSCHSHC	TENM1	716	Q9UKZ4
ECWHCHVRSCQAPRT	TMEM151A	116	Q8N4L1
HLGSCQFHVCPWRRA	SLC23A3	236	Q6PIS1
HPALHWLACCCCLSL	C11orf21	81	Q9P2W6
PCDHVHCLRCLRAWF	RNF213	4011	Q63HN8
CVERFDHHCPWVGNC	ZDHHC9	161	Q9Y397
LHHSNRCSCFHWPGA	TMEM94	56	Q12767
SCNHVFHEFCIRGWC	RNF175	251	Q8N4F7
PCSHTYHCKCIDPWF	ZNRF4	326	Q8WWF5
HLHIWHGKCPFRSFC	UNC5CL	331	Q8IV45
CNHVFHEFCIRGWCI	RNF121	251	Q9H920
ISLCGHLFCWPCLHQ	RNF185	51	Q96GF1
CGHSFCLVCLLRSWE	TRIML1	31	Q8N9V2
HGAFRLQWCPKCCFH	ZDHHC19	106	Q8WVZ1
GHSFCRPCLCLSWEE	TRIM43B	31	A6NCK2
LSALWHPDCFVCREC	TGFB1I1	361	O43294
SWRHCLGPSCDRDCT	ADAMTSL3	1646	P82987