Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	mRNA regulatory element binding translation repressor activity	CPEB2 CPEB4 CPEB3	4.20e-05	17	81	3	GO:0000900
GeneOntologyMolecularFunction	isomerase activity	RGPD4 ENOSF1 RGPD2 FBH1 EHHADH HSD3B1	1.30e-04	192	81	6	GO:0016853
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	P3H3 CYP3A4 KDM4C MICAL2 HSPBAP1 KDM4B	1.38e-04	194	81	6	GO:0016705
GeneOntologyMolecularFunction	2-oxoglutarate-dependent dioxygenase activity	P3H3 KDM4C HSPBAP1 KDM4B	1.41e-04	65	81	4	GO:0016706
GeneOntologyMolecularFunction	bitter taste receptor activity	TAS2R33 TAS2R31 TAS2R43	1.75e-04	27	81	3	GO:0033038
GeneOntologyMolecularFunction	histone H3K9me2/H3K9me3 demethylase activity	KDM4C KDM4B	2.41e-04	6	81	2	GO:0140684
GeneOntologyMolecularFunction	oxidoreductase activity	P3H3 CYP3A4 KDM4C EHHADH MICAL2 HSPBAP1 CAT HSD3B1 AKR1B1 KDM4B PCYOX1	2.58e-04	766	81	11	GO:0016491
GeneOntologyMolecularFunction	taste receptor activity	TAS2R33 TAS2R31 TAS2R43	3.21e-04	33	81	3	GO:0008527
GeneOntologyMolecularFunction	RNA polymerase I general transcription initiation factor activity	UBTF TAF1	5.74e-04	9	81	2	GO:0001181
GeneOntologyMolecularFunction	dioxygenase activity	P3H3 KDM4C HSPBAP1 KDM4B	6.80e-04	98	81	4	GO:0051213
GeneOntologyMolecularFunction	demethylase activity	CYP3A4 KDM4C KDM4B	7.55e-04	44	81	3	GO:0032451
GeneOntologyMolecularFunction	histone H3K36 demethylase activity	KDM4C KDM4B	8.73e-04	11	81	2	GO:0051864
GeneOntologyMolecularFunction	histone H3K9 demethylase activity	KDM4C KDM4B	1.43e-03	14	81	2	GO:0032454
GeneOntologyBiologicalProcess	negative regulation of cytoplasmic translation	CPEB2 CPEB4 CPEB3	7.12e-06	10	82	3	GO:2000766
GeneOntologyBiologicalProcess	negative regulation of cytoplasmic translational elongation	CPEB2 CPEB3	1.56e-05	2	82	2	GO:1900248
GeneOntologyBiologicalProcess	regulation of cytoplasmic translational elongation	CPEB2 CPEB3	4.67e-05	3	82	2	GO:1900247
GeneOntologyBiologicalProcess	spermatid development	CFAP47 FSIP2 EHHADH PEBP1 RNF17 KIT DNAH1	8.32e-05	262	82	7	GO:0007286
GeneOntologyBiologicalProcess	spermatid differentiation	CFAP47 FSIP2 EHHADH PEBP1 RNF17 KIT DNAH1	1.05e-04	272	82	7	GO:0048515
GeneOntologyBiologicalProcess	negative regulation of translational elongation	CPEB2 CPEB3	1.55e-04	5	82	2	GO:0045900
GeneOntologyBiologicalProcess	cytoplasmic translational elongation	CPEB2 CPEB3	1.55e-04	5	82	2	GO:0002182
HumanPheno	Hyperpigmented papule	POGLUT1 POFUT1 KIT	7.03e-06	7	31	3	HP:0025473
HumanPheno	Erythematous papule	POGLUT1 POFUT1 KIT	4.33e-05	12	31	3	HP:0030350
Domain	CEBP_ZZ	CPEB2 CPEB4 CPEB3	3.25e-07	4	82	3	IPR032296
Domain	CEBP_ZZ	CPEB2 CPEB4 CPEB3	3.25e-07	4	82	3	PF16366
Domain	RRM_7	CPEB2 CPEB4 CPEB3	3.25e-07	4	82	3	PF16367
Domain	TUDOR	KDM4C RNF17 KDM4B	1.36e-04	23	82	3	PS50304
Domain	TUDOR	KDM4C RNF17 KDM4B	2.21e-04	27	82	3	SM00333
Domain	Tudor	KDM4C RNF17 KDM4B	3.04e-04	30	82	3	IPR002999
Domain	JMJC	KDM4C HSPBAP1 KDM4B	3.69e-04	32	82	3	PS51184
Domain	JmjC_dom	KDM4C HSPBAP1 KDM4B	3.69e-04	32	82	3	IPR003347
Domain	GCC2_Rab_bind	RGPD4 RGPD2	3.94e-04	7	82	2	IPR032023
Domain	Rab_bind	RGPD4 RGPD2	3.94e-04	7	82	2	PF16704
Domain	JmjC	KDM4C HSPBAP1 KDM4B	4.05e-04	33	82	3	SM00558
Domain	JmjN	KDM4C KDM4B	8.38e-04	10	82	2	SM00545
Domain	JMJN	KDM4C KDM4B	8.38e-04	10	82	2	PS51183
Domain	JmjN	KDM4C KDM4B	8.38e-04	10	82	2	PF02375
Domain	JmjN	KDM4C KDM4B	8.38e-04	10	82	2	IPR003349
Domain	-	RGPD4 RGPD2	8.38e-04	10	82	2	1.10.220.60
Domain	Grip	RGPD4 RGPD2	1.02e-03	11	82	2	SM00755
Domain	GRIP	RGPD4 RGPD2	1.02e-03	11	82	2	PF01465
Domain	Ran_BP1	RGPD4 RGPD2	1.22e-03	12	82	2	PF00638
Domain	GRIP_dom	RGPD4 RGPD2	1.22e-03	12	82	2	IPR000237
Domain	GRIP	RGPD4 RGPD2	1.22e-03	12	82	2	PS50913
Domain	RANBD1	RGPD4 RGPD2	1.22e-03	12	82	2	PS50196
Domain	RanBD	RGPD4 RGPD2	1.44e-03	13	82	2	SM00160
Domain	Ran_bind_dom	RGPD4 RGPD2	1.44e-03	13	82	2	IPR000156
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DNAH1	1.67e-03	14	82	2	IPR024317
Domain	Dynein_HC_stalk	DYNC2H1 DNAH1	1.67e-03	14	82	2	IPR024743
Domain	Dynein_heavy_dom-2	DYNC2H1 DNAH1	1.67e-03	14	82	2	IPR013602
Domain	DHC_N2	DYNC2H1 DNAH1	1.67e-03	14	82	2	PF08393
Domain	MT	DYNC2H1 DNAH1	1.67e-03	14	82	2	PF12777
Domain	AAA_8	DYNC2H1 DNAH1	1.67e-03	14	82	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DYNC2H1 DNAH1	1.67e-03	14	82	2	IPR011704
Domain	AAA_5	DYNC2H1 DNAH1	1.67e-03	14	82	2	PF07728
Domain	DHC_fam	DYNC2H1 DNAH1	1.93e-03	15	82	2	IPR026983
Domain	Dynein_heavy_dom	DYNC2H1 DNAH1	1.93e-03	15	82	2	IPR004273
Domain	Dynein_heavy	DYNC2H1 DNAH1	1.93e-03	15	82	2	PF03028
Domain	Pyr_redox_2	MICAL2 PCYOX1	3.10e-03	19	82	2	PF07992
Domain	EPHD	KDM4C KDM4B	4.15e-03	22	82	2	PS51805
Domain	JmjC	KDM4C KDM4B	4.94e-03	24	82	2	PF02373
Domain	Integrin_dom	ITGA8 ITGB8	5.35e-03	25	82	2	IPR032695
Domain	TAS2R	TAS2R31 TAS2R43	5.78e-03	26	82	2	PF05296
Domain	Bromodomain_CS	BAZ1B TAF1	5.78e-03	26	82	2	IPR018359
Domain	T2R	TAS2R31 TAS2R43	5.78e-03	26	82	2	IPR007960
Domain	PHD	KDM4C BAZ1B KDM4B	7.06e-03	89	82	3	SM00249
Domain	Znf_PHD	KDM4C BAZ1B KDM4B	7.51e-03	91	82	3	IPR001965
Pubmed	CPEB2, a novel putative translational regulator in mouse haploid germ cells.	CPEB2 CPEB4 CPEB3	1.31e-08	3	83	3	12672660
Pubmed	CPEB2-dependent translation of long 3'-UTR Ucp1 mRNA promotes thermogenesis in brown adipose tissue.	CPEB2 CPEB4 CPEB3	5.23e-08	4	83	3	30177570
Pubmed	Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus.	CPEB2 CPEB4 CPEB3	5.23e-08	4	83	3	12871996
Pubmed	A novel role of CPEB3 in regulating EGFR gene transcription via association with Stat5b in neurons.	CPEB2 CPEB4 CPEB3	1.31e-07	5	83	3	20639532
Pubmed	Deficiency of CPEB2-Confined Choline Acetyltransferase Expression in the Dorsal Motor Nucleus of Vagus Causes Hyperactivated Parasympathetic Signaling-Associated Bronchoconstriction.	CPEB2 CPEB4 CPEB3	1.55e-06	10	83	3	27810937
Pubmed	Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjögren's syndrome.	GRAPL GRAP	5.63e-06	2	83	2	15174222
Pubmed	Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin.	TAS2R31 TAS2R43	5.63e-06	2	83	2	17702579
Pubmed	Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling.	GRAPL GRAP	5.63e-06	2	83	2	19836472
Pubmed	Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction.	GRAPL GRAP	5.63e-06	2	83	2	11971956
Pubmed	Role of integrin alpha8 in murine model of lung fibrosis.	ITGA8 ITGB8	5.63e-06	2	83	2	29813125
Pubmed	Structure of human upstream binding factor HMG box 5 and site for binding of the cell-cycle regulatory factor TAF1.	UBTF TAF1	5.63e-06	2	83	2	17505112
Pubmed	Grb2-related adaptor protein GRAP is a novel regulator of liver fibrosis.	GRAPL GRAP	5.63e-06	2	83	2	37343720
Pubmed	Bitter taste receptors for saccharin and acesulfame K.	TAS2R31 TAS2R43	5.63e-06	2	83	2	15537898
Pubmed	The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer.	CPEB2 CPEB3	5.63e-06	2	83	2	32440535
Pubmed	Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity.	KDM4C KDM4B	5.63e-06	2	83	2	24361252
Pubmed	Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.	KDM4C HSPBAP1 DOT1L KDM4B	5.89e-06	49	83	4	34368113
Pubmed	Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing.	CPEB2 CPEB4 CPEB3	1.04e-05	18	83	3	30111840
Pubmed	New nomenclature for chromatin-modifying enzymes.	KDM4C TAF1 DOT1L KDM4B	1.08e-05	57	83	4	18022353
Pubmed	Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development.	KDM4C KDM4B	1.69e-05	3	83	2	27266524
Pubmed	Immunocytochemical demonstration of peroxisomal enzymes in human kidney biopsies.	EHHADH CAT	1.69e-05	3	83	2	2895531
Pubmed	CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA.	CPEB4 CPEB3	1.69e-05	3	83	2	17024188
Pubmed	The histone demethylase JMJD2C is stage-specifically expressed in preimplantation mouse embryos and is required for embryonic development.	KDM4C KDM4B	1.69e-05	3	83	2	19696013
Pubmed	Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms.	FSIP2 KDM4C	1.69e-05	3	83	2	22072270
Pubmed	CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion.	CPEB4 CPEB3	1.69e-05	3	83	2	20937770
Pubmed	[Expression and significance of integrins subunits in laryngeal squamous cell carcinoma].	ITGA8 ITGB8	1.69e-05	3	83	2	20942236
Pubmed	Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells.	KDM4C KDM4B	1.69e-05	3	83	2	17611647
Pubmed	The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance.	KDM4C KDM4B	1.69e-05	3	83	2	31434704
Pubmed	Histone demethylase JMJD2B and JMJD2C induce fibroblast growth factor 2: mediated tumorigenesis of osteosarcoma.	KDM4C KDM4B	1.69e-05	3	83	2	25636512
Pubmed	Global Analysis of CPEBs Reveals Sequential and Non-Redundant Functions in Mitotic Cell Cycle.	CPEB2 CPEB4	1.69e-05	3	83	2	26398195
Pubmed	Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin.	KDM4C KIT KDM4B	1.95e-05	22	83	3	28963472
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	MCMBP FAM50A PEBP1 UBTF POLR2C CAPN2 BAZ1B TAF1 INO80 AKR1B1 AQR	2.91e-05	1014	83	11	32416067
Pubmed	Calpain 2 activated through N-methyl-D-aspartic acid receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons.	CAPN2 CPEB3	3.37e-05	4	83	2	22711986
Pubmed	The histone demethylase Kdm4 suppresses activation of hepatic stellate cell by inducing MiR-29 transcription.	KDM4C KDM4B	3.37e-05	4	83	2	31014673
Pubmed	The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF.	UBTF TAF1	3.37e-05	4	83	2	12498690
Pubmed	Molecular organization of peroxisomal enzymes: protein-protein interactions in the membrane and in the matrix.	EHHADH CAT	3.37e-05	4	83	2	16781659
Pubmed	Immunocytochemical localization of peroxisomal proteins in human liver and kidney.	EHHADH CAT	3.37e-05	4	83	2	9053548
Pubmed	Interferon-induced guanylate-binding proteins: mapping of the murine Gbp-1 locus to chromosome 3.	GBP2 AKR1B1	3.37e-05	4	83	2	3927587
Pubmed	Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.	KDM4C KDM4B	3.37e-05	4	83	2	18713068
Pubmed	Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells.	KDM4C KDM4B	3.37e-05	4	83	2	27257215
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	FLII LRPPRC DYNC2H1 CAT TAF1 DOT1L KDM4B	4.79e-05	398	83	7	35016035
Pubmed	Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells.	KDM4C KDM4B	5.60e-05	5	83	2	16738407
Pubmed	Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase.	CPEB4 CPEB3	5.60e-05	5	83	2	21336257
Pubmed	Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway.	KIT GRAP	5.60e-05	5	83	2	8647802
Pubmed	Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss.	GRAPL GRAP	5.60e-05	5	83	2	30610177
Pubmed	Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.	KDM4C KDM4B	5.60e-05	5	83	2	21914792
Pubmed	Involvement of gp130-associated cytokine signaling in Müller cell activation following optic nerve lesion.	LRPPRC IL6ST	5.60e-05	5	83	2	20091786
Pubmed	PHF8 targets histone methylation and RNA polymerase II to activate transcription.	POLR2C TAF1	5.60e-05	5	83	2	20421419
Pubmed	Molecular mechanisms underlying nucleocytoplasmic shuttling of actinin-4.	UBTF INO80	5.60e-05	5	83	2	20197409
Pubmed	Germ cells.	KIT IL6ST	8.39e-05	6	83	2	9988212
Pubmed	Identification and characterization of JMJD2 family genes in silico.	KDM4C KDM4B	8.39e-05	6	83	2	15138608
Pubmed	Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation.	PEBP1 MAP3K14	8.39e-05	6	83	2	11585904
Pubmed	The murine form of TXK, a novel TEC kinase expressed in thymus maps to chromosome 5.	KIT TXK	8.39e-05	6	83	2	7579892
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	FSIP2 FAM50A UBTF BAZ1B TAF1 INO80 DOT1L KDM4B	1.04e-04	608	83	8	36089195
Pubmed	Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.	RGPD4 RGPD2	1.17e-04	7	83	2	21205196
Pubmed	Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap.	GRAPL GRAP	1.17e-04	7	83	2	15456754
Pubmed	Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.	RGPD4 RGPD2	1.17e-04	7	83	2	18949001
Pubmed	Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.	RGPD4 RGPD2	1.17e-04	7	83	2	25187515
Pubmed	Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.	RGPD4 RGPD2	1.17e-04	7	83	2	9037092
Pubmed	Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.	RGPD4 RGPD2	1.17e-04	7	83	2	8603673
Pubmed	Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development.	KDM4C KDM4B	1.17e-04	7	83	2	21445275
Pubmed	Complex genomic rearrangements lead to novel primate gene function.	RGPD4 RGPD2	1.17e-04	7	83	2	15710750
Pubmed	Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).	RGPD4 RGPD2	1.17e-04	7	83	2	26632511
Pubmed	Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.	RGPD4 RGPD2	1.17e-04	7	83	2	24403063
Pubmed	Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.	RGPD4 RGPD2	1.17e-04	7	83	2	23818861
Pubmed	Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.	RGPD4 RGPD2	1.17e-04	7	83	2	11353387
Pubmed	Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.	KDM4C KDM4B	1.17e-04	7	83	2	28262558
Pubmed	Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.	RGPD4 RGPD2	1.17e-04	7	83	2	30944974
Pubmed	Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.	RGPD4 RGPD2	1.17e-04	7	83	2	38838144
Pubmed	Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.	RGPD4 RGPD2	1.17e-04	7	83	2	23536549
Pubmed	Retina-specifically expressed novel subtypes of bovine cyclophilin.	RGPD4 RGPD2	1.17e-04	7	83	2	7559465
Pubmed	Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.	RGPD4 RGPD2	1.17e-04	7	83	2	17372272
Pubmed	Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.	RGPD4 RGPD2	1.17e-04	7	83	2	38657106
Pubmed	Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.	RGPD4 RGPD2	1.17e-04	7	83	2	12191015
Pubmed	Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	RGPD4 RGPD2	1.17e-04	7	83	2	22821000
Pubmed	Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.	RGPD4 RGPD2	1.17e-04	7	83	2	20682751
Pubmed	The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.	RGPD4 RGPD2	1.56e-04	8	83	2	22262462
Pubmed	The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.	RGPD4 RGPD2	1.56e-04	8	83	2	21670213
Pubmed	Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.	RGPD4 RGPD2	1.56e-04	8	83	2	28745977
Pubmed	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.	RGPD4 RGPD2	1.56e-04	8	83	2	27412403
Pubmed	Epigenetic priming by Dot1l in lymphatic endothelial progenitors ensures normal lymphatic development and function.	DOT1L KIT	1.56e-04	8	83	2	31908356
Pubmed	Mice lacking Ran binding protein 1 are viable and show male infertility.	RGPD4 RGPD2	1.56e-04	8	83	2	21310149
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	RGPD4 FLII RGPD2 LRPPRC UBTF CAPN2 CAT ATP5PD	1.59e-04	647	83	8	26618866
Pubmed	Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.	RGPD4 RGPD2	2.00e-04	9	83	2	18394993
Pubmed	The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.	RGPD4 RGPD2	2.00e-04	9	83	2	11553612
Pubmed	The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.	RGPD4 RGPD2	2.00e-04	9	83	2	10601307
Pubmed	The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.	RGPD4 RGPD2	2.00e-04	9	83	2	9733766
Pubmed	Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.	RGPD4 RGPD2	2.00e-04	9	83	2	28100513
Pubmed	Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.	RGPD4 RGPD2	2.00e-04	9	83	2	28877029
Pubmed	Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.	RGPD4 RGPD2	2.00e-04	9	83	2	17887960
Pubmed	EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes.	POLR2C TAF1	2.50e-04	10	83	2	9488465
Pubmed	Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.	RGPD4 RGPD2	2.50e-04	10	83	2	8857542
Pubmed	The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.	RGPD4 RGPD2	2.50e-04	10	83	2	27160050
Pubmed	Parkin ubiquitinates and promotes the degradation of RanBP2.	RGPD4 RGPD2	2.50e-04	10	83	2	16332688
Pubmed	Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse.	KDM4C KDM4B	2.50e-04	10	83	2	27023172
Pubmed	[Establishment of a multiplex ligation-dependent SNP genotyping method and its application in the detection of genes related to chemotherapeutic drugs in breast cancer].	CYP3A4 CAT	2.50e-04	10	83	2	19538885
Pubmed	Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.	RGPD4 RGPD2	2.50e-04	10	83	2	21859863
Pubmed	An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.	RGPD4 RGPD2	3.05e-04	11	83	2	35771867
Pubmed	De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair.	POLR2C BAZ1B	3.05e-04	11	83	2	31045206
Pubmed	Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.	KDM4C KDM4B	3.05e-04	11	83	2	19144645
Pubmed	RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.	RGPD4 RGPD2	3.05e-04	11	83	2	17069463
Cytoband	4p12	NIPAL1 TXK	5.86e-04	20	82	2	4p12
Cytoband	Ensembl 112 genes in cytogenetic band chr4p12	NIPAL1 TXK	9.96e-04	26	82	2	chr4p12
Cytoband	10p13	FAM171A1 ITGA8	2.71e-03	43	82	2	10p13
Cytoband	17p11.2	FLII GRAPL GRAP	2.95e-03	159	82	3	17p11.2
Cytoband	12p13.2	TAS2R31 TAS2R43	2.97e-03	45	82	2	12p13.2
GeneFamily	Tudor domain containing	KDM4C RNF17 KDM4B	1.72e-04	37	53	3	780
GeneFamily	Taste 2 receptors	TAS2R33 TAS2R31 TAS2R43	2.02e-04	39	53	3	1162
GeneFamily	DNA helicases	FBH1 INO80	1.11e-03	17	53	2	1167
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM4C KDM4B	2.23e-03	24	53	2	485
GeneFamily	SH2 domain containing	GRAPL TXK GRAP	3.24e-03	101	53	3	741
Coexpression	VANTVEER_BREAST_CANCER_ESR1_UP	RNF103 STARD10 GREB1 IL6ST AQR KDM4B	6.97e-06	149	81	6	M393
CoexpressionAtlas	DevelopingKidney_e15.5_Endothelial cells_emap-29977_k-means-cluster#3_top-relative-expression-ranked_1000	FAM171A1 AOAH HIPK2 BAZ1B INO80	2.27e-05	91	79	5	DevelopingKidney_e15.5_Endothelial cells_emap-29977_k3_1000
ToppCell	mild_COVID-19_(asymptomatic)-NK_CD56bright\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	FSIP2 RPGRIP1L EHHADH STARD10 TAS2R31 TXK	3.67e-07	151	82	6	2470162f4b56bc505db166a6eb0fa54847759df8
Computational	Genes upregulated in subsets of cells of a given type within various tumors	PEBP1 GBP2 IGFLR1 IL6ST	7.52e-05	50	49	4	GAVISH_3CA_METAPROGRAM_CD8_T_CELLS_DYSFUNCTION
Computational	Neighborhood of MSH2	LRPPRC MRPS18B PARG BAZ1B	1.64e-04	61	49	4	MORF_MSH2
Drug	neoglucobrassicin	CYP3A4 GRAPL GRAP	3.72e-06	9	82	3	CID000656564
Drug	Doxepin hydrochloride [1229-29-4]; Up 200; 12.6uM; HL60; HT_HG-U133A	KDM4C AOAH BAZ1B GBP2 HSD3B1 F12 KDM4B	7.17e-06	197	82	7	2384_UP
Drug	Clorgyline hydrochloride [17780-75-5]; Down 200; 13uM; MCF7; HT_HG-U133A	MCMBP KDM4C DYNC2H1 MICAL2 POLR2C GBP2 KDM4B	7.41e-06	198	82	7	3219_DN
Disease	Dowling-Degos disease (is_implicated_in)	POGLUT1 POFUT1	2.07e-05	3	78	2	DOID:0060256 (is_implicated_in)
Disease	Dowling-Degos disease	POGLUT1 POFUT1	2.07e-05	3	78	2	cv:C3714534
Disease	Reticulate acropigmentation of Kitamura	POGLUT1 POFUT1	4.12e-05	4	78	2	C0406811
Disease	Dowling-Degos disease 1	POGLUT1 POFUT1	4.12e-05	4	78	2	C4552092
Disease	medulloblastoma (is_marker_for)	KDM4C KDM4B	6.86e-05	5	78	2	DOID:0050902 (is_marker_for)
Disease	dowling-degos disease	POGLUT1 POFUT1	6.86e-05	5	78	2	C3714534
Disease	glycosyl-N-behenoyl-sphingadienine (d18:2/22:0) measurement	NIPAL1 TXK	1.44e-04	7	78	2	EFO_0800520
Disease	glycosyl-N-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2OH)) measurement	NIPAL1 TXK	1.91e-04	8	78	2	EFO_0800533
Disease	Childhood Medulloblastoma	KDM4C STRADA KDM4B	2.03e-04	43	78	3	C0278510
Disease	Melanotic medulloblastoma	KDM4C STRADA KDM4B	2.03e-04	43	78	3	C1275668
Disease	Medullomyoblastoma	KDM4C STRADA KDM4B	2.03e-04	43	78	3	C0205833
Disease	Desmoplastic Medulloblastoma	KDM4C STRADA KDM4B	2.03e-04	43	78	3	C0751291
Disease	Adult Medulloblastoma	KDM4C STRADA KDM4B	2.03e-04	43	78	3	C0278876
Disease	glycosyl-N-palmitoyl-sphingosine (d18:1/16:0) measurement	NIPAL1 TXK	2.45e-04	9	78	2	EFO_0800476
Disease	alopecia areata (is_marker_for)	KDM4C KDM4B	3.06e-04	10	78	2	DOID:986 (is_marker_for)
Disease	Medulloblastoma	KDM4C STRADA KDM4B	3.18e-04	50	78	3	C0025149
Disease	male infertility (implicated_via_orthology)	CFAP47 KIT	5.28e-04	13	78	2	DOID:12336 (implicated_via_orthology)
Disease	Antihypertensive use measurement	DIP2B INO80 AKR1B1 KDM4B MADD	6.96e-04	265	78	5	EFO_0009927
Disease	serum metabolite measurement	ENOSF1 LRPPRC MAGEL2 PTPRH CYP3A4 KDM4C NIPAL1 CAT F12	8.61e-04	945	78	9	EFO_0005653
Disease	protein C measurement	MYO7B BAZ1B	9.14e-04	17	78	2	EFO_0004633
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	DIP2B KDM4B	9.14e-04	17	78	2	DOID:0060307 (is_implicated_in)
Disease	depressive disorder (implicated_via_orthology)	RNF103 ATP5PD	1.54e-03	22	78	2	DOID:1596 (implicated_via_orthology)
Disease	frailty measurement	LRPPRC INO80	1.68e-03	23	78	2	EFO_0009885
Disease	body fat distribution	DIP2B UBTF AOAH ITGB8	2.05e-03	202	78	4	EFO_0004341
Disease	chronic obstructive pulmonary disease	HMCN1 CPEB4 ITGA8 POFUT1 VARS2 DOT1L ITGB8	2.29e-03	688	78	7	EFO_0000341
Disease	sciatic neuropathy (biomarker_via_orthology)	CAPN2 CAT HSD3B1	2.32e-03	99	78	3	DOID:11446 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
VYVHLDFPDKTWPPE	ADGRF3	126	Q8IZF5
WKPHEVLKDLPLGSY	DISP3	316	Q9P2K9
PFDLTKVWPHKDYPL	CAT	296	P04040
WPAPYPHSKKLAEKA	HSD3B1	151	P14060
KWAPPKFLPHKYDVK	BAZ1B	211	Q9UIG0
GFIPKNYIRVKPHPW	GRAPL	46	Q8TC17
GFIPKNYIRVKPHPW	GRAP	46	Q13588
DKKKYPYWPHQPIEN	ATP5PD	146	O75947
VPAWEIFKKKPDHFP	AQR	106	O60306
EPAVYPWPLPVYDKH	DOT1L	16	Q8TEK3
DLYLIHWPTGFKPGK	AKR1B1	106	P15121
DHEPVKPKPLTYWKD	P3H3	431	Q8IVL6
PKFKVLPYWGNPHDR	INO80	591	Q9ULG1
PLCHLYPLPKETWKF	AOAH	121	P28039
FYPQLKPWVHYIPVK	POGLUT1	301	Q8NBL1
TLPPLAAYLYPPKHW	P2RY11	81	Q96G91
SKHAYVPNSAPWKPI	FAM171A1	91	Q5VUB5
HVPEDFWPPQPKLYK	FLII	716	Q13045
SPYPLWRLKTPDDHE	HIPK2	441	Q9H2X6
CKDLWYLDTEKPPAP	HCFC2	346	Q9Y5Z7
FDPALIGDKPKWYAH	MADD	571	Q8WXG6
KKDPQSWPFHYLEAL	MAGEL2	1206	Q9UJ55
HVILKWKFAYLPPSG	RPGRIP1L	911	Q68CZ1
SDPWPDLELFKKLPF	GREB1	1396	Q4ZG55
IDPTQLPYDHKWEFP	KIT	571	P10721
KPFHELPFYQKVWLL	KIAA2026	416	Q5HYC2
KYLSLFDVDPEKPPW	FSIP2	1231	Q5CZC0
LHRDPKYWTEPEKFL	CYP3A4	401	P08684
QYDKPLGRIHKPDPW	EHHADH	581	Q08426
HQYPDGEVWKKLLPA	ENOSF1	426	Q7L5Y1
KPWLAYPHYKPPEKC	PCYOX1	431	Q9UHG3
KYVPPHLSPDKKWLG	PARG	441	Q86W56
PDAPSRKDPKYREWH	PEBP1	71	P30086
KATPFWSHLLPGPKE	FAM214B	281	Q7L5A3
DSKYLSKPPKDWQPH	DIP2B	491	Q9P265
PKSWYAIPPEHGKRL	KDM4B	206	O94953
EPKSWYAIPPEHGKR	KDM4C	206	Q9H3R0
KEEGFPIRPHYFWPL	LRPPRC	431	P42704
FDWPAPKKYLAHLEQ	GBP2	236	P32456
APLYHWRTLKPTPEK	ITGA8	151	P53708
PFPDIHWFKDGKPLF	HMCN1	1481	Q96RW7
KQFHWYKDLLPLLPG	ITGB8	346	P26012
VPELWSAKAYPSLKP	DNAH1	4071	Q9P2D7
PHPWKNEKYFPETLD	DYNC2H1	311	Q8NCM8
KRWHLFPPEDTPFLY	HSPBAP1	191	Q96EW2
IISDPLFIPWKKLYH	FBH1	246	Q8NFZ0
PSKAPSFWYKIDPSH	IL6ST	326	P40189
DWPHKAESKSYFPPK	CPEB2	361	Q7Z5Q1
WPHKAESKSYFPPKG	CPEB3	471	Q8NE35
TWEKPILEPPYIEAH	GPHB5	66	Q86YW7
KHIFPASRWEPYDPE	FAM50A	316	Q14320
VPHDPYVKISDSFWP	CENPK	226	Q9BS16
HLCWPKEKADPYPYP	IGFLR1	186	Q9H665
DWPHKAESKSYFPPK	CPEB4	501	Q17RY0
IAEWYELKKPPPNLF	CAPN2	211	P17655
PDLWLHPLIPTDYIK	RNF103	496	O00237
ERKTPFYPPPLLDWK	SLC13A5	386	Q86YT5
PKYFYIPEKISIPWI	CFAP47	2246	Q6ZTR5
EWKPVYKHPLVFVLL	NIPAL1	266	Q6NVV3
PKWVPSLNEVPLHYL	MCMBP	46	Q9BTE3
PLYLPHHPKPEWAEY	MICAL2	1341	O94851
LKSPWRGEYKEPRHP	MAP3K14	661	Q99558
KLAPTHWPPEKRVAY	POFUT1	111	Q9H488
PPWEAPKEHKYKAEE	F12	21	P00748
YPSIHPFILIWGNKK	TAS2R31	271	P59538
YPSIHPFILIWGNKK	TAS2R33	271	P0DSN6
YPSIHPFILIWGNKK	TAS2R43	271	P59537
YLEAVKPVLWHSPRP	VARS2	821	Q5ST30
FKTPEKEPPLWHAEF	RGPD4	1636	Q7Z3J3
HDFPKYSVKVLPWLS	STRADA	231	Q7RTN6
KYPEWKQKHLPHFKP	STARD10	221	Q9Y365
YTFKTPEKEPPLWHA	RGPD2	1626	P0DJD1
WPFHHPVNKKFVPDY	TAF1	1526	P21675
ALRHTVYPKPEEWPK	POLR2C	191	P19387
LPIFWLKPTYPKEIQ	CNMD	196	O75829
ELPKNPWEKLSIHLY	RNF17	1326	Q9BXT8
VPISPYKDEPWKYLE	MRPS18B	46	Q9Y676
DLPRKKYPAWDAHFI	XKR7	526	Q5GH72
YPFPLHDKERLEKWL	THAP5	26	Q7Z6K1
PWYIDPSKRPTLKHQ	SLU7	71	O95391
AKFPIKWSPPEVFLF	TXK	426	P42681
PEKPKTPQQLWYTHE	UBTF	196	P17480
YDWSRVPLKPIHEEP	PTPRH	856	Q9HD43
FFPPHPYKLWKQERE	TM7SF3	511	Q9NS93
IPHKLYRTKPPDRWA	MYO7B	1356	Q6PIF6