Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentT-tubule

ANK3 CACNB2 AHNAK2

6.58e-0579213GO:0030315
GeneOntologyCellularComponentcostamere

ANK3 AHNAK2

2.19e-0422212GO:0043034
GeneOntologyCellularComponentsupramolecular fiber

ANK3 RSPH1 LMOD2 TSC1 NICN1 AHNAK2

8.28e-041179216GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

ANK3 RSPH1 LMOD2 TSC1 NICN1 AHNAK2

8.58e-041187216GO:0099081
GeneOntologyCellularComponentsarcolemma

ANK3 CACNB2 AHNAK2

8.71e-04190213GO:0042383
GeneOntologyCellularComponentsarcomere

ANK3 LMOD2 AHNAK2

1.89e-03249213GO:0030017
GeneOntologyCellularComponentmyofibril

ANK3 LMOD2 AHNAK2

2.46e-03273213GO:0030016
GeneOntologyCellularComponentphotoreceptor inner segment

USH2A PHLPP2

2.76e-0378212GO:0001917
GeneOntologyCellularComponentcontractile muscle fiber

ANK3 LMOD2 AHNAK2

2.92e-03290213GO:0043292
GeneOntologyCellularComponentspecific granule membrane

STK10 LAMTOR1

3.73e-0391212GO:0035579
GeneOntologyCellularComponentsecretory granule membrane

SLC30A8 STK10 LAMTOR1

4.16e-03329213GO:0030667
DomainPDZ

AHNAK2 FRMPD4

7.15e-03141172PF00595
DomainPDZ

AHNAK2 FRMPD4

7.85e-03148172SM00228
Domain-

AHNAK2 FRMPD4

8.05e-031501722.30.42.10
DomainPDZ

AHNAK2 FRMPD4

8.16e-03151172PS50106
DomainPDZ

AHNAK2 FRMPD4

8.26e-03152172IPR001478
PathwayREACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK

TSC1 LAMTOR1

3.66e-0429142MM14980
PathwayREACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK

TSC1 LAMTOR1

3.66e-0429142M19861
PathwayREACTOME_MTOR_SIGNALLING

TSC1 LAMTOR1

7.35e-0441142M27000
PathwayREACTOME_MTOR_SIGNALLING

TSC1 LAMTOR1

7.71e-0442142MM14638
Pubmed

Role of Ragulator in the Regulation of Mechanistic Target of Rapamycin Signaling in Podocytes and Glomerular Function.

TSC1 LAMTOR1

3.47e-07221227032892
Pubmed

A β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice.

ANK3 CACNB2

5.20e-06621220877009
Pubmed

Genome-wide association study of bipolar I disorder in the Han Chinese population.

ANK3 CACNB2

5.20e-06621220386566
Pubmed

R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.

TSC1 PRPF6 MAP7D1 LAMTOR1

2.89e-0530021428561026
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

ANK3 TSC1 PRPF6 MAP7D1

2.03e-0449721436774506
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

ANK3 CACNB2 TSC1 MAP7D1 LAMTOR1

2.27e-0496321528671696
InteractionLYN interactions

BLNK ANK3 STK10 AHNAK2 LAMTOR1 MS4A2 FRMPD4

5.41e-06720217int:LYN
InteractionBSND interactions

SLC30A8 ANK3 MAP7D1

3.90e-0564213int:BSND
GeneFamilyPDZ domain containing

AHNAK2 FRMPD4

3.02e-031521021220
ToppCellPND07-28-samps-Myeloid-Macrophage-macrophage_-_intermediate_-_unactivated|PND07-28-samps / Age Group, Lineage, Cell class and subclass

BLNK MS4A2 FRMPD4

2.04e-051142131c99483a492d08b6bb745006fe24c22841dc57ad
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_activate-7|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

BLNK AHNAK2 FRMPD4

3.16e-05132213c07842a4b514f1e950c8af303f3b6b4275906e6a
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NICN1 PHLPP2 FRMPD4

5.71e-051612130d863d7d369391dd6148e1de6d6f8033dcb8fe0f
ToppCellE18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BLNK RSPH1 AHNAK2

6.94e-0517221376c06a968d3333441eed103abef1e636a1c3e7a1
ToppCellfacs-Marrow-B-cells-24m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BLNK SLC30A8 USH2A

7.31e-05175213887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BLNK SLC30A8 USH2A

7.43e-05176213c6484334187f64cd00cd35e77d8ae436556b4260
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

SLC30A8 USH2A CACNB2

8.07e-05181213c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCellLV-15._Ventricular_Cardiomyocyte_III|LV / Chamber and Cluster_Paper

ANK3 LMOD2 CACNB2

8.48e-05184213ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ANK3 CACNB2 AHNAK2

8.61e-051852136712512100ccef456d2e2bd201d0987986c92ac9
ToppCellLV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

ANK3 LMOD2 CACNB2

8.61e-051852136baccb26f999145e51b91d94315bf8d4655bef31
ToppCellRV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

ANK3 LMOD2 CACNB2

9.18e-051892130a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCellRV-15._Ventricular_Cardiomyocyte_III|RV / Chamber and Cluster_Paper

ANK3 LMOD2 CACNB2

9.32e-0519021393c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCellThalamus-Neuronal|Thalamus / BrainAtlas - Mouse McCarroll V32

SRRM3 NICN1 FRMPD4

9.76e-05193213712a4acd1167e43543950bc819ff11984e6f718d
ToppCellCOVID-19-Heart-CM_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

ANK3 LMOD2 CACNB2

9.76e-05193213dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCellCOVID-19-Heart-CM_1|Heart / Disease (COVID-19 only), tissue and cell type

ANK3 LMOD2 CACNB2

1.01e-04195213f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCellCOVID-19-Heart-CM_2|Heart / Disease (COVID-19 only), tissue and cell type

ANK3 LMOD2 CACNB2

1.01e-0419521375fc81bddb246dca3b437fb60827b1d4fe416405
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANK3 SRRM3 FRMPD4

1.05e-041982130ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

ANK3 SRRM3 FRMPD4

1.08e-0420021348d801219bc771d6c7e151dc88ca4c179988de85
Diseasecognitive inhibition measurement

USH2A CACNB2

5.79e-0450212EFO_0007969
DiseaseNonorganic psychosis

ANK3 LMOD2

1.10e-0369212C0349204
DiseaseRetinitis pigmentosa

USH2A PRPF6

1.26e-0374212cv:C0035334
Diseaseattention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia

ANK3 CACNB2

2.33e-03101212EFO_0003756, EFO_0003761, EFO_0003888, MONDO_0004985, MONDO_0005090
DiseasePsychotic Disorders

ANK3 LMOD2

2.33e-03101212C0033975
DiseaseRetinitis Pigmentosa

USH2A PRPF6

2.47e-03104212C0035334
DiseaseCiliopathies

USH2A TSC1

2.76e-03110212C4277690
Diseasebipolar I disorder

ANK3 CACNB2

4.49e-03141212EFO_0009963
DiseaseAlzheimer disease

BLNK ANK3 MS4A2

4.71e-03485213MONDO_0004975

Protein segments in the cluster

PeptideGeneStartEntry
SASSPPLHTWLTVLK

MS4A2

41

Q01362
KSLKSSDPWHPPSLS

DCANP1

176

Q8TF63
WKATHPPSSSLPNPL

CACNB2

461

Q08289
VSPRHSPWSSPKLPK

LMOD2

391

Q6P5Q4
LPSKPSWPSEKARLT

BLNK

136

Q8WV28
KLSSHRTKSSGWPPP

FRMPD4

11

Q14CM0
PLKSIWSVSTPSPIK

ANK3

1536

Q12955
PKSKARPSSPSTSWH

MAP7D1

461

Q3KQU3
SSSLTHWKKLPPLPS

LAMTOR1

96

Q6IAA8
HWKKLPPLPSLTSQP

LAMTOR1

101

Q6IAA8
PPVAKSLPSSLLLSW

USH2A

2061

O75445
SLPSSLLLSWNPPKK

USH2A

2066

O75445
TKHWSSSSASPPPKK

SRRM3

156

A6NNA2
LKKCPHSTPLWLLLS

PRPF6

736

O94906
KSPSVTFPKWLSHPV

NICN1

141

Q9BSH3
ELALWTPTLPKKPTS

RSPH1

216

Q8WYR4
KIPSLGWSPSKHTKT

AHNAK2

586

Q8IVF2
LSLFSLWLSSKPPSK

SLC30A8

116

Q8IWU4
PSWKHKLSQAPLLPS

TSC1

101

Q92574
WILPKPHISSTPLTI

PHLPP2

961

Q6ZVD8
KSDPPTLLTPSKWSV

STK10

251

O94804
SWSALKAPKSLPTHL

TTC41P

66

Q6P2S7
ILSHSWLQPPKPKAT

TSSK2

266

Q96PF2