Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	[heparan sulfate]-glucosamine N-sulfotransferase activity	NDST1 NDST2 NDST4 NDST3	2.00e-09	4	135	4	GO:0015016
GeneOntologyMolecularFunction	N-acetylglucosamine deacetylase activity	NDST1 NDST2 NDST4 NDST3	2.00e-09	4	135	4	GO:0050119
GeneOntologyMolecularFunction	heparan sulfate N-deacetylase activity	NDST1 NDST2 NDST3	3.02e-07	3	135	3	GO:0102140
GeneOntologyMolecularFunction	transmembrane transporter activity	ATP6V0A1 IPO8 SLC2A8 SLC31A1 SLCO3A1 GRIA1 SLCO6A1 NCS1 RYR3 ABCB1 SLC6A2 SLC6A3 GJB5 SV2A TRPV2 ABCB11 SV2C SLC2A13 SLC39A14 SEC63 ANO3 ATP4A SLC35A5 ATP5F1C	1.15e-06	1180	135	24	GO:0022857
GeneOntologyMolecularFunction	heparan sulfate sulfotransferase activity	NDST1 NDST2 NDST4 NDST3	2.57e-06	15	135	4	GO:0034483
GeneOntologyMolecularFunction	transporter activity	ATP6V0A1 IPO8 SLC2A8 SLC31A1 SLCO3A1 GRIA1 SLCO6A1 NCS1 RYR3 ABCB1 SLC6A2 SLC6A3 GJB5 SV2A TRPV2 ABCB11 SV2C SLC2A13 SLC39A14 SEC63 ANO3 ATP4A SLC35A5 ATP5F1C	5.32e-06	1289	135	24	GO:0005215
GeneOntologyMolecularFunction	active transmembrane transporter activity	ATP6V0A1 IPO8 SLC2A8 SLCO3A1 SLCO6A1 ABCB1 SLC6A2 SLC6A3 ABCB11 SLC2A13 SLC39A14 ATP4A SLC35A5	2.17e-05	477	135	13	GO:0022804
GeneOntologyMolecularFunction	ATP-dependent activity	UBA5 MYH11 ATP6V0A1 IPO8 SMCHD1 OLA1 KIF20B KIF7 ABCB1 SMC3 ABCB11 YME1L1 ATP4A ATP5F1C	7.27e-05	614	135	14	GO:0140657
GeneOntologyMolecularFunction	norepinephrine:sodium symporter activity	SLC6A2 SLC6A3	1.36e-04	3	135	2	GO:0005334
GeneOntologyMolecularFunction	deacetylase activity	NDST1 NDST2 NDST4 NDST3	1.51e-04	40	135	4	GO:0019213
GeneOntologyMolecularFunction	dopamine:sodium symporter activity	SLC6A2 SLC6A3	2.70e-04	4	135	2	GO:0005330
GeneOntologyMolecularFunction	sulfotransferase activity	NDST1 NDST2 NDST4 NDST3	5.22e-04	55	135	4	GO:0008146
GeneOntologyMolecularFunction	monoatomic anion:monoatomic cation symporter activity	SLC6A2 SLC6A3 SLC39A14	7.01e-04	26	135	3	GO:0015296
GeneOntologyMolecularFunction	ATP hydrolysis activity	SMCHD1 OLA1 KIF20B KIF7 ABCB1 SMC3 ABCB11 YME1L1 ATP4A ATP5F1C	8.43e-04	441	135	10	GO:0016887
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ATP6V0A1 IPO8 ABCB1 ABCB11 ATP4A	8.73e-04	109	135	5	GO:0042626
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC2A8 SLCO3A1 SLCO6A1 SLC6A2 SLC6A3 SLC2A13 SLC39A14 SLC35A5	9.25e-04	296	135	8	GO:0015291
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	ATP6V0A1 SLC31A1 GRIA1 NCS1 RYR3 SLC6A2 SLC6A3 TRPV2 SLC2A13 SLC39A14 ATP4A ATP5F1C	1.14e-03	627	135	12	GO:0022890
GeneOntologyMolecularFunction	organic hydroxy compound transmembrane transporter activity	SLC6A2 SLC6A3 ABCB11 SLC2A13	1.30e-03	70	135	4	GO:1901618
GeneOntologyMolecularFunction	xenobiotic transmembrane transporter activity	SLC31A1 ABCB1 ABCB11	1.55e-03	34	135	3	GO:0042910
GeneOntologyMolecularFunction	transferase activity, transferring sulphur-containing groups	NDST1 NDST2 NDST4 NDST3	1.59e-03	74	135	4	GO:0016782
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	ATP6V0A1 SLC31A1 GRIA1 NCS1 RYR3 SLC6A2 SLC6A3 TRPV2 SLC2A13 SLC39A14 ATP4A ATP5F1C	1.85e-03	664	135	12	GO:0008324
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	ATP6V0A1 SLC31A1 GRIA1 NCS1 RYR3 SLC6A2 SLC6A3 TRPV2 SLC2A13 SLC39A14 ANO3 ATP4A ATP5F1C	1.91e-03	758	135	13	GO:0015318
GeneOntologyMolecularFunction	MAP kinase tyrosine phosphatase activity	DUSP1 DUSP6	1.97e-03	10	135	2	GO:0033550
GeneOntologyBiologicalProcess	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	NDST1 NDST2 NDST4 NDST3	1.13e-07	8	133	4	GO:0015014
GeneOntologyBiologicalProcess	heparin biosynthetic process	NDST1 NDST2 NDST4 NDST3	5.26e-07	11	133	4	GO:0030210
GeneOntologyBiologicalProcess	heparin metabolic process	NDST1 NDST2 NDST4 NDST3	3.68e-06	17	133	4	GO:0030202
GeneOntologyBiologicalProcess	mucopolysaccharide metabolic process	NDST1 NDST2 NDST4 CEMIP2 NDST3 CLTC B4GALT4	3.85e-06	100	133	7	GO:1903510
GeneOntologyBiologicalProcess	carbohydrate metabolic process	NDST1 MOGAT1 PGGHG SLC2A8 PDK3 NDST2 NDST4 PFKFB4 KBTBD2 NDST3 ENO4 CASD1 GYS1 CLTC SLC39A14 B4GALT4	4.27e-06	646	133	16	GO:0005975
GeneOntologyBiologicalProcess	polysaccharide biosynthetic process	NDST1 NDST2 NDST4 NDST3 GYS1 CLTC	9.69e-06	76	133	6	GO:0000271
GeneOntologyBiologicalProcess	glycosaminoglycan biosynthetic process	NDST1 NDST2 NDST4 NDST3 CLTC B4GALT4	9.69e-06	76	133	6	GO:0006024
GeneOntologyBiologicalProcess	aminoglycan biosynthetic process	NDST1 NDST2 NDST4 NDST3 CLTC B4GALT4	1.30e-05	80	133	6	GO:0006023
GeneOntologyBiologicalProcess	glycosaminoglycan metabolic process	NDST1 NDST2 NDST4 CEMIP2 NDST3 CLTC B4GALT4	1.36e-05	121	133	7	GO:0030203
GeneOntologyBiologicalProcess	aminoglycan metabolic process	NDST1 NDST2 NDST4 CEMIP2 NDST3 CLTC B4GALT4	2.39e-05	132	133	7	GO:0006022
GeneOntologyBiologicalProcess	heparan sulfate proteoglycan biosynthetic process	NDST1 NDST2 NDST4 NDST3	7.41e-05	35	133	4	GO:0015012
GeneOntologyBiologicalProcess	polysaccharide metabolic process	NDST1 NDST2 NDST4 NDST3 GYS1 CLTC	1.68e-04	126	133	6	GO:0005976
Domain	Heparan_SO4_deacetylase	NDST1 NDST2 NDST4 NDST3	2.46e-09	4	133	4	IPR021930
Domain	HSNSD	NDST1 NDST2 NDST4 NDST3	2.46e-09	4	133	4	PF12062
Domain	ARM-type_fold	RALGAPA1 USP34 IPO8 DOCK11 PUM2 PSMD5 ARMCX3 RYR3 CLTC TAF2 LRBA PUM1	5.66e-06	339	133	12	IPR016024
Domain	LIMR	LMBR1 LMBR1L	5.03e-05	2	133	2	IPR008075
Domain	Pumilio_RNA-bd	PUM2 PUM1	5.03e-05	2	133	2	IPR033712
Domain	Sugar_transporter_CS	SLC2A8 SV2A SV2C SLC2A13	7.57e-05	32	133	4	IPR005829
Domain	MFS_sugar_transport-like	SLC2A8 SV2A SV2C SLC2A13	1.21e-04	36	133	4	IPR005828
Domain	Sulfotransfer_1	NDST1 NDST2 NDST4 NDST3	1.21e-04	36	133	4	PF00685
Domain	Sulfotransferase_dom	NDST1 NDST2 NDST4 NDST3	1.21e-04	36	133	4	IPR000863
Domain	Sugar_tr	SLC2A8 SV2A SV2C SLC2A13	1.21e-04	36	133	4	PF00083
Domain	PUF	PUM2 PUM1	1.50e-04	3	133	2	PF00806
Domain	SV2	SV2A SV2C	1.50e-04	3	133	2	IPR022308
Domain	PUM_HD	PUM2 PUM1	1.50e-04	3	133	2	PS50303
Domain	PUM-HD	PUM2 PUM1	1.50e-04	3	133	2	IPR033133
Domain	Pentapeptide_4	SV2A SV2C	1.50e-04	3	133	2	PF13599
Domain	VWF_type-D	MUC19 VWDE FCGBP	1.85e-04	16	133	3	IPR001846
Domain	VWFD	MUC19 VWDE FCGBP	1.85e-04	16	133	3	PS51233
Domain	VWD	MUC19 VWDE FCGBP	1.85e-04	16	133	3	SM00216
Domain	VWD	MUC19 VWDE FCGBP	1.85e-04	16	133	3	PF00094
Domain	5peptide_repeat	SV2A SV2C	2.99e-04	4	133	2	IPR001646
Domain	LMBR1	LMBR1 LMBR1L	2.99e-04	4	133	2	PF04791
Domain	PUM	PUM2 PUM1	2.99e-04	4	133	2	PS50302
Domain	Pumilio_RNA-bd_rpt	PUM2 PUM1	2.99e-04	4	133	2	IPR001313
Domain	LMBR1-like_membr_prot	LMBR1 LMBR1L	2.99e-04	4	133	2	IPR006876
Domain	Pumilio	PUM2 PUM1	2.99e-04	4	133	2	SM00025
Domain	MFS_dom	SLC2A8 SLCO3A1 SLCO6A1 SV2A SV2C SLC2A13	3.97e-04	134	133	6	IPR020846
Domain	SMC_hinge	SMCHD1 SMC3	7.41e-04	6	133	2	SM00968
Domain	SMC_hinge	SMCHD1 SMC3	7.41e-04	6	133	2	PF06470
Domain	SMC_hinge	SMCHD1 SMC3	7.41e-04	6	133	2	IPR010935
Domain	P-loop_NTPase	NDST1 MYH11 NDST2 NDST4 PFKFB4 OLA1 KIF20B NLRC4 KIF7 ABCB1 NDST3 RAB28 SMC3 ABCB11 YME1L1	1.05e-03	848	133	15	IPR027417
Pathway	KEGG_MEDICUS_REFERENCE_HEPARAN_SULFATE_BIOSYNTHESIS	NDST1 NDST2 NDST4 NDST3	8.53e-07	11	103	4	M47921
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	ATP6V0A1 SLC2A8 SLC31A1 SLCO3A1 PSMD5 ADCY7 RYR3 ABCB1 SLC6A2 SLC6A3 CLTC TRPV2 SLC2A13 SLC39A14 YME1L1 ANO3 ATP4A	2.23e-05	736	103	17	M27287
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	ATP6V0A1 SLC2A8 SLC31A1 SLCO3A1 PSMD5 RYR3 ABCB1 SLC6A2 SLC6A3 CLTC TRPV2 SLC2A13 SLC39A14 YME1L1 ANO3 ATP4A	3.26e-05	681	103	16	MM14985
Pathway	KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE	NDST1 NDST2 NDST4 NDST3	3.55e-05	26	103	4	M7330
Pathway	REACTOME_HS_GAG_BIOSYNTHESIS	NDST1 NDST2 NDST4 NDST3	5.55e-05	29	103	4	MM14802
Pathway	REACTOME_HS_GAG_BIOSYNTHESIS	NDST1 NDST2 NDST4 NDST3	7.27e-05	31	103	4	M685
Pathway	WP_GLYCOSAMINOGLYCAN_SYNTHESIS_IN_FIBROBLASTS	NDST1 NDST2 NDST4 NDST3	2.21e-04	41	103	4	M48095
Pathway	REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS	SLC31A1 SLC6A2 SLC6A3 SLC2A13 SLC39A14	2.31e-04	76	103	5	MM15072
Pubmed	Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.	NDST1 NDST2 NDST4 NDST3	2.17e-10	4	135	4	22049073
Pubmed	Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites.	NDST1 NDST2 NDST4 NDST3	2.17e-10	4	135	4	12070138
Pubmed	Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4.	NDST1 NDST2 NDST4 NDST3	1.08e-09	5	135	4	11087757
Pubmed	FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing β-catenin signaling.	NDST1 NDST2 NDST4 NDST3	1.50e-08	8	135	4	24067353
Pubmed	Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family.	NDST1 NDST2 NDST3	5.72e-08	3	135	3	9915799
Pubmed	Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain.	NDST1 NDST2 NDST4 NDST3	7.01e-08	11	135	4	15944372
Pubmed	Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling.	NDST1 NDST2 NDST4 NDST3	1.05e-07	12	135	4	12460940
Pubmed	Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses.	NDST1 NDST2 NDST3	2.28e-07	4	135	3	16056228
Pubmed	Heparan Sulfate Proteoglycan Sulfation Regulates Uterine Differentiation and Signaling During Embryo Implantation.	NDST1 NDST2 NDST3	2.28e-07	4	135	3	29688404
Pubmed	Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.	NDST1 MYH11 NDST2 NDST4 NDST3 KIT	7.82e-07	81	135	6	39217171
Pubmed	Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development.	NDST1 NDST2 NDST4 NDST3	1.00e-06	20	135	4	17107998
Pubmed	NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development.	NDST1 NDST2 NDST4 NDST3	1.50e-06	22	135	4	19299468
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	SEMA4B EPHA6 MMP28 TMEM161B MMP27 ARMCX3 NLRC4 KIF7 NXPE3 NDST3 EYS LMBR1L DPEP2 YME1L1 SLC35A5 B4GALT4	1.51e-06	985	135	16	12975309
Pubmed	Altered heparan sulfate structure in mice with deleted NDST3 gene function.	NDST1 NDST2 NDST3	1.98e-06	7	135	3	18385133
Pubmed	Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans.	ABCB1 SLC6A2 SLC6A3	1.98e-06	7	135	3	19844206
Pubmed	Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function.	NDST1 MYH11 NDST2 KIT	2.17e-06	24	135	4	34653670
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	USP34 DUSP1 DUSP6 LMBR1 SLCO3A1 DAZL CEMIP2 EYS GPR149 KIT	6.11e-06	420	135	10	28065597
Pubmed	Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation.	NLRC4 TRPV2 PLCB2	1.23e-05	12	135	3	25959047
Pubmed	ABCB11 and ABCB1 gene polymorphisms impact on telaprevir pharmacokinetic at one month of therapy.	ABCB1 ABCB11	1.50e-05	2	135	2	25661339
Pubmed	Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins.	PUM2 PUM1	1.50e-05	2	135	2	12459267
Pubmed	Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins.	PUM2 PUM1	1.50e-05	2	135	2	29165587
Pubmed	Developmental origin and Kit-dependent development of the interstitial cells of cajal in the mammalian small intestine.	MYH11 KIT	1.50e-05	2	135	2	9438424
Pubmed	Signaling via Src family kinases is required for normal internalization of the receptor c-Kit.	CLTC KIT	1.50e-05	2	135	2	10477727
Pubmed	[Expression of MDR1 and KIT in imatinib-resistant gastrointestinal stromal tumor cells].	ABCB1 KIT	1.50e-05	2	135	2	20658364
Pubmed	PUMILIO-mediated translational control of somatic cell cycle program promotes folliculogenesis and contributes to ovarian cancer progression.	PUM2 PUM1	1.50e-05	2	135	2	35507203
Pubmed	Bespoke RNA recognition by Pumilios.	PUM2 PUM1	1.50e-05	2	135	2	26517885
Pubmed	Mouse Pum1 and Pum2 genes, members of the Pumilio family of RNA-binding proteins, show differential expression in fetal and adult hematopoietic stem cells and progenitors.	PUM2 PUM1	1.50e-05	2	135	2	12667987
Pubmed	Smchd1 is a maternal effect gene required for genomic imprinting.	SMCHD1 KIT	1.50e-05	2	135	2	33186096
Pubmed	Connexin 31.1 degradation requires the Clathrin-mediated autophagy in NSCLC cell H1299.	GJB5 CLTC	1.50e-05	2	135	2	25388970
Pubmed	A Quantitative and Predictive Model for RNA Binding by Human Pumilio Proteins.	PUM2 PUM1	1.50e-05	2	135	2	31078383
Pubmed	Principles of mRNA control by human PUM proteins elucidated from multimodal experiments and integrative data analysis.	PUM2 PUM1	1.50e-05	2	135	2	32753408
Pubmed	Effects of PUMILIO1 and PUMILIO2 knockdown on cardiomyogenic differentiation of human embryonic stem cells culture.	PUM2 PUM1	1.50e-05	2	135	2	32437472
Pubmed	Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups.	NDST1 NDST2	1.50e-05	2	135	2	15319440
Pubmed	Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation.	NDST1 NDST2	1.50e-05	2	135	2	16984905
Pubmed	Structural domains of chimeric dopamine-noradrenaline human transporters involved in the Na(+)- and Cl(-)-dependence of dopamine transport.	SLC6A2 SLC6A3	1.50e-05	2	135	2	11093780
Pubmed	PPAPDC1B and WHSC1L1 are common drivers of the 8p11-12 amplicon, not only in breast tumors but also in pancreatic adenocarcinomas and lung tumors.	PLPP5 NSD3	1.50e-05	2	135	2	24051013
Pubmed	Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model.	PUM2 PUM1	1.50e-05	2	135	2	32316190
Pubmed	Insulin in the ventral tegmental area reduces hedonic feeding and suppresses dopamine concentration via increased reuptake.	SLC6A2 SLC6A3	1.50e-05	2	135	2	22712725
Pubmed	Compensatory role of P-glycoproteins in knockout mice lacking the bile salt export pump.	ABCB1 ABCB11	1.50e-05	2	135	2	19650158
Pubmed	Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini.	SLC6A2 SLC6A3	1.50e-05	2	135	2	26786096
Pubmed	N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland.	NDST1 NDST2	1.50e-05	2	135	2	23060443
Pubmed	Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns.	NDST1 NDST2	1.50e-05	2	135	2	10758005
Pubmed	Expression and function of variants of human catecholamine transporters lacking the fifth transmembrane region encoded by exon 6.	SLC6A2 SLC6A3	1.50e-05	2	135	2	20700532
Pubmed	Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2.	NDST1 NDST2	1.50e-05	2	135	2	12634318
Pubmed	A role for cortical dopamine in the paradoxical calming effects of psychostimulants.	SLC6A2 SLC6A3	1.50e-05	2	135	2	35210489
Pubmed	Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes.	NDST2 NDST3	1.50e-05	2	135	2	12417402
Pubmed	Genetic complementation screen identifies a mitogen-activated protein kinase phosphatase, MKP3, as a regulator of dopamine transporter trafficking.	DUSP6 SLC6A3	1.50e-05	2	135	2	18434601
Pubmed	Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer.	PUM2 PUM1	1.50e-05	2	135	2	12771951
Pubmed	Alternate modes of cognate RNA recognition by human PUMILIO proteins.	PUM2 PUM1	1.50e-05	2	135	2	21397187
Pubmed	Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines.	SLC6A2 SLC6A3	1.50e-05	2	135	2	11784783
Pubmed	Dopamine and norepinephrine transporter-dependent c-Fos production in vitro: relevance to neuroadaptation.	SLC6A2 SLC6A3	1.50e-05	2	135	2	15763138
Pubmed	cDNA cloning and sequencing of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase, an enzyme involved in the biosynthesis of heparin.	NDST1 NDST2	1.50e-05	2	135	2	8144627
Pubmed	Identification and expression in mouse of two heparan sulfate glucosaminyl N-deacetylase/N-sulfotransferase genes.	NDST1 NDST2	1.50e-05	2	135	2	9565617
Pubmed	Intravenous cocaine induced-activity and behavioural sensitization in norepinephrine-, but not dopamine-transporter knockout mice.	SLC6A2 SLC6A3	1.50e-05	2	135	2	12193195
Pubmed	PUMILIO proteins promote colorectal cancer growth via suppressing p21.	PUM2 PUM1	1.50e-05	2	135	2	35338151
Pubmed	Undersulfation of heparan sulfate restricts differentiation potential of mouse embryonic stem cells.	NDST1 NDST2	1.50e-05	2	135	2	22298785
Pubmed	Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system.	PUM2 PUM1	1.50e-05	2	135	2	18776931
Pubmed	Heparin/heparan sulfate biosynthesis: processive formation of N-sulfated domains.	NDST1 NDST2	1.50e-05	2	135	2	18487608
Pubmed	Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation.	GRIA1 SLC6A3	1.50e-05	2	135	2	21209835
Pubmed	Site-directed mutations near transmembrane domain 1 alter conformation and function of norepinephrine and dopamine transporters.	SLC6A2 SLC6A3	1.50e-05	2	135	2	21149640
Pubmed	Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins.	PUM2 DAZL PUM1	1.59e-05	13	135	3	12511597
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	PIGN USP34 NDST1 SEMA4B ATP6V0A1 ANPEP TMEM161B CEMIP2 NXPE3 PTPRK SLC39A14 SEC63 KDSR DNASE2 PLXNA1 B4GALT4	1.81e-05	1201	135	16	35696571
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	USP34 IPO8 SMCHD1 DUSP1 DUSP6 PPIL4 ARMCX3 GSN KIF7 PTPRK SMC3 MARK2 SEC63 YME1L1	2.75e-05	974	135	14	28675297
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	RALGAPA1 ARMCX3 ANKRD27 CEMIP2 SV2A LRBA SEC63 YME1L1 ATP4A PLXNA1	2.93e-05	504	135	10	34432599
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	PIGN CUL3 SF3B4 SMCHD1 PPIL4 ZFC3H1 KIF20B GSN NSD3 SMC3 NAT10 CLTC MARK2 SEC63 ATP4A ATP5F1C	3.14e-05	1257	135	16	36526897
Pubmed	Proteome analysis of the circadian clock protein PERIOD2.	CPNE9 SMCHD1 MCCC2 GSN CLTC	3.40e-05	94	135	5	35122331
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RALGAPA1 CUL3 USP34 SMCHD1 FASTKD2 KBTBD2 ANKRD27 CEMIP2 NAT10 DEPDC5	4.39e-05	529	135	10	14621295
Pubmed	KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice.	MYH11 KIT	4.48e-05	3	135	2	22160378
Pubmed	Monitoring of post-transplant CBFB-MYH11 as minimal residual disease, rather than KIT mutations, can predict relapse after allogeneic haematopoietic cell transplantation in adults with inv(16) acute myeloid leukaemia.	MYH11 KIT	4.48e-05	3	135	2	27650511
Pubmed	Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolism.	LMBR1 LMBR1L	4.48e-05	3	135	2	19136951
Pubmed	Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs.	PUM2 PUM1	4.48e-05	3	135	2	30333515
Pubmed	Expression pattern of synaptic vesicle protein 2 (SV2) isoforms in patients with temporal lobe epilepsy and hippocampal sclerosis.	SV2A SV2C	4.48e-05	3	135	2	23617838
Pubmed	A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection.	PUM2 PUM1	4.48e-05	3	135	2	25340845
Pubmed	inv(16)/t(16;16) acute myeloid leukemia with non-type A CBFB-MYH11 fusions associate with distinct clinical and genetic features and lack KIT mutations.	MYH11 KIT	4.48e-05	3	135	2	23160462
Pubmed	Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins.	PUM2 PUM1	4.48e-05	3	135	2	26724866
Pubmed	Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions.	SLC6A2 SLC6A3	4.48e-05	3	135	2	12401330
Pubmed	Human ABCB1 with an ABCB11-like degenerate nucleotide binding site maintains transport activity by avoiding nucleotide occlusion.	ABCB1 ABCB11	4.48e-05	3	135	2	33031417
Pubmed	Identification and characterization of RNA sequences to which human PUMILIO-2 (PUM2) and deleted in Azoospermia-like (DAZL) bind.	PUM2 DAZL	4.48e-05	3	135	2	15607425
Pubmed	NAT10-mediated mRNA N4-acetylcytidine modification of MDR1 and BCRP promotes breast cancer progression.	ABCB1 NAT10	4.48e-05	3	135	2	38409918
Pubmed	Sexual congruency in the connectome and translatome of VTA dopamine neurons.	SLC31A1 SLC6A3	4.48e-05	3	135	2	28894175
Pubmed	Expression of SV2 isoforms during rodent brain development.	SV2A SV2C	4.48e-05	3	135	2	23937191
Pubmed	Differentiation of two human neuroblastoma cell lines alters SV2 expression patterns.	SV2A SV2C	4.48e-05	3	135	2	33588752
Pubmed	Small changes in lymphocyte development and activation in mice through tissue-specific alteration of heparan sulphate.	NDST1 NDST2	4.48e-05	3	135	2	18479348
Pubmed	Pesticide-induced gene mutations and Parkinson disease risk: a meta-analysis.	ABCB1 SLC6A3	4.48e-05	3	135	2	23987116
Pubmed	Response to methylphenidate in adults with ADHD is associated with a polymorphism in SLC6A3 (DAT1).	SLC6A2 SLC6A3	4.48e-05	3	135	2	17955457
Pubmed	Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome.	PUM2 PUM1	4.48e-05	3	135	2	33397688
Pubmed	NORAD: Defender of the Genome.	PUM2 PUM1	4.48e-05	3	135	2	27157388
Pubmed	Cocaine-conditioned locomotion in dopamine transporter, norepinephrine transporter and 5-HT transporter knockout mice.	SLC6A2 SLC6A3	4.48e-05	3	135	2	19482066
Pubmed	Functional overlap between chondroitin and heparan sulfate proteoglycans during VEGF-induced sprouting angiogenesis.	NDST1 NDST2	4.48e-05	3	135	2	22345168
Pubmed	LMBRD1: the gene for the cblF defect of vitamin B₁₂ metabolism.	LMBR1 LMBR1L	4.48e-05	3	135	2	20446115
Pubmed	PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells.	PUM2 PUM1	4.48e-05	3	135	2	28232582
Pubmed	CD40-modulated dual-specificity phosphatases MAPK phosphatase (MKP)-1 and MKP-3 reciprocally regulate Leishmania major infection.	DUSP1 DUSP6	4.48e-05	3	135	2	21471446
Pubmed	Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans.	ANPEP SLCO3A1	4.48e-05	3	135	2	19330903
Pubmed	Modulation of olfactory bulb tyrosine hydroxylase and catecholamine transporter mRNA by estrogen.	SLC6A2 SLC6A3	4.48e-05	3	135	2	12480184
Pubmed	No association between SLC6A2, SLC6A3, DRD2 polymorphisms and schizophrenia in the Han Chinese population.	SLC6A2 SLC6A3	4.48e-05	3	135	2	28454051
Pubmed	Deficiency of Cullin 3, a Protein Encoded by a Schizophrenia and Autism Risk Gene, Impairs Behaviors by Enhancing the Excitability of Ventral Tegmental Area (VTA) DA Neurons.	CUL3 SLC6A3	4.48e-05	3	135	2	37558490
Pubmed	No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy.	SV2A SV2C	4.48e-05	3	135	2	18977120
Pubmed	SV2 is the protein receptor for botulinum neurotoxin A.	SV2A SV2C	4.48e-05	3	135	2	16543415
Pubmed	COP9 signalosome component CSN-5 stabilizes PUF proteins FBF-1 and FBF-2 in Caenorhabditis elegans germline stem and progenitor cells.	PUM2 PUM1	4.48e-05	3	135	2	38427913
Pubmed	Differential distribution and developmental expression of synaptic vesicle protein 2 isoforms in the mouse retina.	SV2A SV2C	4.48e-05	3	135	2	12687700
Interaction	C1orf54 interactions	NDST1 SEMA4B B4GALNT4 NDST2 CEMIP2 NXPE3 PLXNA1 B4GALT4	1.22e-05	167	129	8	int:C1orf54
Interaction	NDST4 interactions	NDST1 NDST4 NDST3	1.40e-05	8	129	3	int:NDST4
Interaction	NDST3 interactions	NDST2 NDST4 NDST3	2.09e-05	9	129	3	int:NDST3
GeneFamily	Sulfotransferases, membrane bound	NDST1 NDST2 NDST4 NDST3	5.06e-05	37	100	4	763
GeneFamily	Solute carriers	SLC2A8 SLC31A1 SLCO3A1 SLCO6A1 SLC6A2 SLC6A3 SLC2A13 SLC39A14 SLC35A5	3.42e-04	395	100	9	752
GeneFamily	MAP kinase phosphatases	DUSP1 DUSP6	1.61e-03	11	100	2	895
GeneFamily	ATP binding cassette subfamily B	ABCB1 ABCB11	1.61e-03	11	100	2	806
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	RALGAPA1 CUL3 USP34 PGGHG DOCK11 SMCHD1 DUSP1 DUSP6 NDST2 PUM2 ZFC3H1 KBTBD2 FASLG ADCY7 ABCB1 NXPE3 SMC3 TRPV2 PLCB2 LRBA KIT YME1L1 PSD4	1.95e-06	1492	134	23	M40023
Coexpression	GSE40666_UNTREATED_VS_IFNA_STIM_STAT4_KO_EFFECTOR_CD8_TCELL_90MIN_DN	ATP6V0A1 PLPP5 INPP5A CEMIP2 NSD3 ABCB1 PTPRK PUM1	8.83e-06	199	134	8	M9236
Coexpression	GSE41867_LCMV_ARMSTRONG_VS_CLONE13_DAY8_EFFECTOR_CD8_TCELL_UP	SEMA4B SLC31A1 DOCK11 DUSP6 NDST2 ARMCX3 NSD3 RASIP1	9.16e-06	200	134	8	M9478
Coexpression	GABRIELY_MIR21_TARGETS	CUL3 USP34 SLC31A1 LMBR1 ARMCX3 CEMIP2 SEC63 YME1L1 ANO3	1.86e-05	289	134	9	M2196
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EPHA6 DOCK11 NDST4 SV2A GPR149 SV2C KIT	2.09e-06	193	135	7	9f9eb241b0b82a6f12de6921c3acf6fed7cf65bb
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MOGAT1 ANPEP DOCK11 NLRC4 DPEP2 TRPV2 MS4A14	2.47e-06	198	135	7	e125eb8aa57c172e5518874da1bd25998292f5e2
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MOGAT1 ANPEP DOCK11 NLRC4 DPEP2 TRPV2 MS4A14	2.47e-06	198	135	7	0baeb8e2c199ff10bb5c829c523546af3c9227c1
ToppCell	Parenchymal-NucSeq-Immune_Myeloid\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MOGAT1 ANPEP DOCK11 NLRC4 DPEP2 MS4A14 PLCB2	2.56e-06	199	135	7	7ee2805fd9143eba11bf6832267b62189683608b
ToppCell	LPS_only-Myeloid-Monocytes,_Macrophages-T-cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SF3B4 EPHA6 DPEP2 SV2C PLCB2 KIT	8.82e-06	158	135	6	91d8c93af328c3bbebe1d8f019b94849ebc548c0
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-Tuft-related-Tuft\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	B4GALNT4 AOC1 NDST4 ADCY7 PLCB2 KIT	1.02e-05	162	135	6	80619a93c57fe16daf91dc571874ef9ac888953d
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_LINC00507_PSRC1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EPHA6 RGS22 NDST3 EYS PTPRK ANO3	1.13e-05	165	135	6	6de69b75174731931e7e80a3488f983a7ba4defe
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AOC1 CYP2F1 SLC31A1 GSN SERPINA11 FCGBP	1.48e-05	173	135	6	e4d9a9a781acc531bc81c3fcee24d637e805c8e1
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP2F1 GJB5 FCGBP PTPRK NAT10 KIT	1.58e-05	175	135	6	31f0fb2e47e357dbf9c15436b7df85b3c370ded7
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK11 DUSP1 CEMIP2 DPEP2 GYS1 KIT	1.58e-05	175	135	6	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-LTi-like_NCR+_ILC3\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLCO3A1 RGS9 ANKRD27 EYS KIT PSD4	1.74e-05	178	135	6	0b59e3d75b143bd7bf91a7800a49699c51e68c5a
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MOGAT1 ANPEP NLRC4 DPEP2 TRPV2 DNASE2	1.74e-05	178	135	6	0b398656f26c4061b11ccf98908d0e2e1367585a
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNDIG1L DAZL RGS9 RYR3 SLC2A13 ANO3	1.97e-05	182	135	6	d41ff834b8fc1d0e23cac7ae261de5f72874e462
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 SLCO3A1 RGS9 ABCB1 SLC6A3 SLC2A13	1.97e-05	182	135	6	5e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNDIG1L DAZL RGS9 RYR3 SLC2A13 ANO3	1.97e-05	182	135	6	6cde859edfe7607bd7ada89d20258413d06f4207
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1_LAMP5_NDNF\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MYH11 EPHA6 ADGRB1 NDST4 SV2C KIT	2.22e-05	186	135	6	310d16f4e5cffee3ea6d7635508c513a3b92131e
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-naive_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLPP5 SLCO3A1 ARMCX3 ANKRD27 KIT B4GALT4	2.36e-05	188	135	6	e079a3873cf442e98ff41a240c80b80995aace11
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4B DUSP1 DUSP6 TMEM135 GSN CLTC	2.43e-05	189	135	6	6dd4ec5ce4beb856f0d2d1654e3c4676d1d63736
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4B DUSP1 DUSP6 TMEM135 GSN CLTC	2.43e-05	189	135	6	3ae479ec7e00c57127cbe51a398329b10ca9848c
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4B DUSP1 DUSP6 TMEM135 GSN CLTC	2.43e-05	189	135	6	875df61ee48baa5142ba4d2427bdec1c53e5a828
ToppCell	facs-Brain_Myeloid-Striatum-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4B DUSP1 DUSP6 TMEM135 GSN CLTC	2.43e-05	189	135	6	97ef5215d841ff366a3e3682cd9bd04100cbfde0
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	RALGAPA1 USP34 LMBR1 PTPRK CLTC PUM1	2.74e-05	193	135	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR-_ILC3\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FASLG ABCB1 SERPINA11 EYS KIT PSD4	2.74e-05	193	135	6	d8e6a7f1da4506acaa06380b4aec3fe299ec8b7e
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-NK-NK-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RALGAPA1 INPP5A TMEM135 SLCO3A1 VWDE YME1L1	2.82e-05	194	135	6	3211d89440a6f4a9b3d4cfb755890816944242ec
ToppCell	droplet-Spleen-SPLEEN-30m-Lymphocytic-plasma_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBA5 ATP6V0A1 PLPP5 ARMCX3 RASIP1 SEC63	2.90e-05	195	135	6	f9a90cd7b4e99a0947fdb3645f7787d02b0f7ca0
ToppCell	Bronchus_Control_(B.)-Immune-TX-TRAM-2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	SYNDIG1L DOCK11 PFKFB4 ADCY7 NLRC4 TRPV2	3.07e-05	197	135	6	eecb693367510da20a6b1e9355e68785a1e3b85c
Drug	Fluorescent Dyes	ABCB1 SLC6A2 SLC6A3	7.59e-07	4	132	3	ctd:D005456
Drug	NSC638615	FASLG ABCB1 TRPV2 ABCB11 MARK2 YME1L1 PLXNA1	3.02e-06	107	132	7	CID000097535
Drug	sarcosinamide	ABCB1 SLC6A2 SLC6A3	6.55e-06	7	132	3	CID000151411
Drug	AC-759	FASLG ABCB1 GYS1 ABCB11 YME1L1 PLXNA1	1.24e-05	88	132	6	CID000005396
Drug	Ethamivan [304-84-7]; Up 200; 18uM; MCF7; HT_HG-U133A	PIGN IPO8 PGGHG SMCHD1 DUSP6 NDST2 PLXNA1 PSD4	2.01e-05	197	132	8	7021_UP
Drug	magnesium	MYH11 PLPP5 ANPEP MMP28 MMP27 GRIA1 RGS9 PFKFB4 ZDHHC17 ADCY7 GSN RYR3 ABCB1 RAB28 GYS1 PLCB2 LRBA YME1L1 ATP4A DNASE2 ATP5F1C	2.48e-05	1325	132	21	CID000000888
Drug	6-methylpurine-2'-deoxyriboside	ABCB1 SLC6A2 SLC6A3 GYS1 ABCB11	2.78e-05	61	132	5	CID000097184
Drug	AC1L8KHA	FASLG ABCB1 YME1L1	3.04e-05	11	132	3	CID000383008
Drug	AC1L9061	ABCB1 YME1L1	3.34e-05	2	132	2	CID000390506
Drug	Bupropion	SLC6A2 SLC6A3	3.34e-05	2	132	2	DB01156
Drug	NSC73306	SLC31A1 ABCB1	3.34e-05	2	132	2	ctd:C511311
Drug	Diethylpropion	SLC6A2 SLC6A3	3.34e-05	2	132	2	DB00937
Drug	Phenmetrazine	SLC6A2 SLC6A3	3.34e-05	2	132	2	DB00830
Drug	RTI-4793-14	SLC6A2 SLC6A3	3.34e-05	2	132	2	CID000192688
Drug	8-Bromo Cyclic Adenosine Monophosphate	CYP2F1 DOCK11 DUSP1 DUSP6 GRIA1 FASLG ARMCX3 ADCY7 RYR3 SERPINA11 RASIP1 ABCB11 SV2C ATP4A	5.14e-05	693	132	14	ctd:D015124
Drug	D-161 compound	SLC6A2 SLC6A3	9.97e-05	3	132	2	ctd:C532102
Drug	6-fluorodopamine	SLC6A2 SLC6A3	9.97e-05	3	132	2	CID000122236
Drug	Mazindol	SLC6A2 SLC6A3	9.97e-05	3	132	2	DB00579
Drug	Methylphenidate	SLC6A2 SLC6A3	9.97e-05	3	132	2	DB00422
Drug	Duloxetine	SLC6A2 SLC6A3	9.97e-05	3	132	2	DB00476
Drug	2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone	SLC6A2 SLC6A3	9.97e-05	3	132	2	ctd:C569113
Drug	Venlafaxine	SLC6A2 SLC6A3	9.97e-05	3	132	2	DB00285
Drug	4-fluoroamphetamine	SLC6A2 SLC6A3	9.97e-05	3	132	2	ctd:C040639
Drug	Sibutramine	SLC6A2 SLC6A3	9.97e-05	3	132	2	DB01105
Drug	RTI-219	SLC6A2 SLC6A3	9.97e-05	3	132	2	CID010524711
Drug	2-(4-bromo-2,5-dimethoxyphenyl)ethylamine	SLC6A2 SLC6A3	9.97e-05	3	132	2	ctd:C079321
Drug	1-phenyl-2-(1-pyrrolidinyl)-1-pentanone	SLC6A2 SLC6A3	9.97e-05	3	132	2	ctd:C000592273
Drug	difluoropine	SLC6A2 SLC6A3	9.97e-05	3	132	2	CID000190851
Drug	Dexmethylphenidate	SLC6A2 SLC6A3	9.97e-05	3	132	2	DB06701
Drug	Elacridar	ABCB1 ABCB11	9.97e-05	3	132	2	ctd:C083501
Drug	2-(4-bromo-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine	SLC6A2 SLC6A3	9.97e-05	3	132	2	ctd:C000595926
Drug	1,4-diazabicyclo[3.3.1]nonane	SLC6A2 SLC6A3	9.97e-05	3	132	2	CID015140257
Drug	5-(2-aminopropyl)benzofuran	SLC6A2 SLC6A3	9.97e-05	3	132	2	ctd:C000608250
Drug	4-methoxymethamphetamine	SLC6A2 SLC6A3	9.97e-05	3	132	2	ctd:C060169
Drug	2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine	SLC6A2 SLC6A3	9.97e-05	3	132	2	ctd:C554181
Drug	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester	ABCB1 ABCB11	9.97e-05	3	132	2	ctd:C541506
Drug	AC1L87CG	ABCB1 YME1L1	9.97e-05	3	132	2	CID000373763
Disease	autism spectrum disorder (implicated_via_orthology)	NDST1 NDST2 NDST4 SLC6A2 SLC6A3 NDST3 LRBA	5.21e-06	152	130	7	DOID:0060041 (implicated_via_orthology)
Disease	azoospermia (implicated_via_orthology)	NDST1 NDST2 NDST4 NDST3	5.84e-06	27	130	4	DOID:14227 (implicated_via_orthology)
Disease	colorectal adenocarcinoma (implicated_via_orthology)	ABCB1 YME1L1	1.93e-05	2	130	2	DOID:0050861 (implicated_via_orthology)
Disease	Intellectual Disability	RALGAPA1 UBA5 NDST1 SLC31A1 TMEM135 GRIA1 KIF7 SLC6A3 TAF2 PUM1	3.04e-05	447	130	10	C3714756
Disease	Mental Depression	DUSP1 DUSP6 GRIA1 ADCY7 ABCB1 SLC6A2 SLC6A3	1.39e-04	254	130	7	C0011570
Disease	alkaline phosphatase measurement	RALGAPA1 USP34 SEMA4B B4GALNT4 AOC1 PGGHG TMEM135 SYAP1 VWDE GSN RASIP1 DPEP2 ABCB11 LRBA	1.60e-04	1015	130	14	EFO_0004533
Disease	Acute myelomonocytic leukemia	MYH11 KIT	1.91e-04	5	130	2	C0023479
Disease	Depressive disorder	DUSP1 DUSP6 GRIA1 ADCY7 ABCB1 SLC6A2 SLC6A3	3.04e-04	289	130	7	C0011581
Disease	intellectual disability (implicated_via_orthology)	NDST1 NDST2 NDST4 NDST3	3.43e-04	75	130	4	DOID:1059 (implicated_via_orthology)
Disease	Profound Mental Retardation	NDST1 SLC31A1 TMEM135 KIF7 TAF2	3.85e-04	139	130	5	C0020796
Disease	Mental Retardation, Psychosocial	NDST1 SLC31A1 TMEM135 KIF7 TAF2	3.85e-04	139	130	5	C0025363
Disease	Mental deficiency	NDST1 SLC31A1 TMEM135 KIF7 TAF2	3.85e-04	139	130	5	C0917816
Disease	Schizophrenia	INPP5A GRIA1 RGS9 ADCY7 NCS1 GSN ABCB1 SLC6A2 SLC6A3 NDST3 SV2A MARK2	5.47e-04	883	130	12	C0036341
Disease	body weights and measures	SF3B4 AOC1 SV2A	6.30e-04	38	130	3	EFO_0004324
Disease	Non-Small Cell Lung Carcinoma	TMEM135 FASLG ABCB1 GIPR KIT	6.52e-04	156	130	5	C0007131
Disease	cystic fibrosis (implicated_via_orthology)	ABCB1 ABCB11	6.80e-04	9	130	2	DOID:1485 (implicated_via_orthology)
Disease	visual epilepsy (biomarker_via_orthology)	DUSP1 DUSP6 GRIA1 ABCB1	6.86e-04	90	130	4	DOID:11832 (biomarker_via_orthology)
Disease	body height at birth	SF3B4 PABPC4L SV2A	7.33e-04	40	130	3	EFO_0006784
Disease	bitter beverage consumption measurement	CUL3 TMEM161B PFKFB4	8.46e-04	42	130	3	EFO_0010089
Disease	carbohydrate measurement	GRIA1 GSN EYS	1.10e-03	46	130	3	EFO_0004998
Disease	congenital diaphragmatic hernia (implicated_via_orthology)	NDST1 KIF7	1.24e-03	12	130	2	DOID:3827 (implicated_via_orthology)
Disease	N-acetylputrescine measurement	AOC1 SLC6A2	1.24e-03	12	130	2	EFO_0800127
Disease	Manganese Poisoning	SLC31A1 SLC39A14	1.69e-03	14	130	2	C0677050
Disease	Testicular Germ Cell Tumor	DAZL KIT	1.69e-03	14	130	2	C1336708
Disease	body weights and measures, body height	SF3B4 SV2A	1.95e-03	15	130	2	EFO_0004324, EFO_0004339
Disease	hepatic encephalopathy (biomarker_via_orthology)	GRIA1 ABCB1	1.95e-03	15	130	2	DOID:13413 (biomarker_via_orthology)
Disease	Intrahepatic cholestasis of pregnancy	ABCB1 ATP4A	2.22e-03	16	130	2	EFO_0009048
Disease	phosphatidylcholine 38:6 measurement	FASTKD2 DEPDC5	2.22e-03	16	130	2	EFO_0010388
Disease	Psychoses, Substance-Induced	RGS9 SLC6A3	2.51e-03	17	130	2	C0033941
Disease	epilepsy (biomarker_via_orthology)	GRIA1 ABCB1	3.83e-03	21	130	2	DOID:1826 (biomarker_via_orthology)
Disease	chronic myeloid leukemia (is_implicated_in)	FASLG ABCB1	3.83e-03	21	130	2	DOID:8552 (is_implicated_in)
Disease	Psychoses, Drug	RGS9 SLC6A3	3.83e-03	21	130	2	C0033937
Disease	cardiovascular system disease (is_implicated_in)	GIPR GYS1	3.83e-03	21	130	2	DOID:1287 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FQSQFSPAVFVYKGG	BTN2A3P	66	Q96KV6
YFGGVTALSREQFFK	B4GALT4	231	O60513
LVQGKFFGYFSAAAV	ADGRB1	46	O14514
FTQFLQGYAFAKSGE	ABCB11	811	O95342
FAKLGFEIFLSSFQG	GIPR	371	P48546
KLFNDYGGGSFSFSN	ANPEP	886	P15144
SDDFYTFGSIFLEKG	ADCY7	566	P51828
FNSNFKGGFNFYAGL	AOC1	431	P19801
TPYSAAKFALDGFFG	HSD11B1L	176	Q7Z5J1
NQFGEGSLFFFLKEF	ARMCX3	326	Q9UH62
TTNFGKRGIFYFFNN	ALPK1	1206	Q96QP1
AKVTYLFDNGGTVFF	ANO3	461	Q9BYT9
TNFTFNLGFSGKFYH	NDST3	341	O95803
DLVSQTFGYLFFFSN	RASIP1	766	Q5U651
TFGKQYKQTIGLDFF	RAB28	36	P51157
FQYFLKKEFSGENLG	RGS9	316	O75916
YPAFFNFTKGNGIAF	CYP2F1	101	P24903
IKAGFAALQLEYFFT	OLA1	296	Q9NTK5
GNYVIQKFFEFGSLD	PUM2	776	Q8TB72
IFGQLYGDQASFFEA	PPIL4	66	Q8WUA2
SFITFFLQGFTFGKA	ABCB1	766	P08183
TRQFYFVHSAGQFKG	ANKRD27	936	Q96NW4
YFEKAVNGFLADLFT	DEPDC5	191	O75140
VGAFGNFSVNYSDFK	MOGAT1	116	Q96PD6
DAAFQYKGFFFFSRG	MMP27	426	Q9H306
YKGFFFFSRGSKQFE	MMP27	431	Q9H306
FQFLSQGFYCGVGLF	DNAJC14	306	Q6Y2X3
KDAGLFFPSFNGNSY	EYS	2141	Q5T1H1
AGFQKIYKQFFPFGD	NCS1	46	P62166
GSRFTEFKAFYGDTL	MCCC2	341	Q9HCC0
LSQEFEAFFQGKSLY	NLRC4	571	Q9NPP4
DVGKTSAYFNFAFKG	KIT	496	P10721
FAFFFLESEGFAGLK	LMBR1	126	Q8WVP7
SSVVGFYSLRFFGNF	LMBR1	361	Q8WVP7
YLKDFFSNVRAAGFD	DDX58	566	O95786
SYGDFIKNQADGYLF	EFHC2	306	Q5JST6
FGFVYQDEFVSSQLK	PLXNA1	216	Q9UIW2
SYFVFGDFNFRLDSK	INPP5A	226	Q14642
ASDFLYGNKSISFIG	OR2L5	81	Q8NG80
NQSYTDGFFLLGIFS	OR2V1	6	Q8NHB1
NQSYTDGFFLLGIFS	OR2V2	6	Q96R30
GAYKSFNGRIFFFES	MUC19	486	Q7Z5P9
IFNFGEQNGYKTFFV	PFKFB4	141	Q16877
LTHYFQSFFNGKGKI	KIF20B	436	Q96Q89
FASAAAFGDKIFYIG	KBTBD2	461	Q8IY47
AFFEGFNATVFAYGQ	KIF7	81	Q2M1P5
NFTFNLGYSGKFFHT	NDST1	351	P52848
FTTYFLNLQGGKFDH	LRBA	2321	P50851
GIFYQGNKLNFSFSE	PGGHG	626	Q32M88
NFTFNLGFSGKFYHT	NDST4	341	Q9H3R1
GNKSISFAGCFTQYF	OR2AP1	86	Q8NGE2
GKIASFFSNNLDYFI	PPP1R21	481	Q6ZMI0
QFELFGFTLIFFKSG	GPR75	356	O95800
TLFEFVFKGFDALQY	NAT10	321	Q9H0A0
FNDVYAASKFALEGF	RDH8	151	Q9NYR8
VFGNYVIQKFFEFGS	PUM1	896	Q14671
GFEFNLSFQKSYGIY	GPR149	396	Q86SP6
FTNFGKGIRYVSFEQ	FBXO17	236	Q96EF6
FLAYSQGAFEKIFSL	CASD1	566	Q96PB1
AGAVFQSFAKFSKFG	DNASE2	221	O00115
GFIFNLINDYISGFS	DOCK11	1041	Q5JSL3
GTFFRVAFYGQSFFE	DOCK11	1761	Q5JSL3
AQVFFLKGGYEAFSA	DUSP1	116	P28562
FDGRKFDFQGTCNYV	FCGBP	4086	Q9Y6R7
TGQVLFQRFFYTKSF	CCNL2	101	Q96S94
FKQTIAGDFEYFLNL	CUL3	366	Q13618
FTFVDYIKGGTQLNF	CPNE9	286	Q8IYJ1
YDKGSTIFLGFSGNF	CEMIP2	1316	Q9UHN6
NAQSVIFGGYAFFKL	MS4A14	196	Q96JA4
IADFGFSNEFTFGNK	MARK2	191	Q7KZI7
NGTLGFKEEHTFFYF	ENO4	571	A6NNW6
SFYNNISGLTDFGEK	DPEP2	231	Q9H4A9
SGYEFDEGSIIFNKF	ATP5F1C	176	P36542
GFESATFLGYFKSGL	GSN	151	P06396
TGVSKGYGFVSFFND	DAZL	76	Q92904
SQFSKGVYAIFGFYE	GRIA1	76	P42261
FFIAGRYEFSNKGAD	GYS1	326	P13807
FEGLLSGVNKYSTAF	GJB5	6	O95377
TFYFGFKNVELLFSG	SLC31A1	46	O15431
YLEGGFSKFQAEFSL	DUSP6	131	Q16828
VSKSAVVFGGFYLFF	SLC39A14	221	Q15043
FGFTAYSASKFAIRG	KDSR	181	Q06136
FQIGAIQSFAGFTDY	ATP4A	866	P20648
TYQFFIRASTVKGFG	PTPRK	566	Q15262
ASEFTNVYIKNFGGD	PABPC4L	186	P0CB38
GQYKNNFVAAGFTTF	EPHA6	976	Q9UF33
GFTFENKGVLSAFNF	IPO8	1016	O15397
AAVSLNDGDFYFFKG	MMP28	376	Q9H239
FFASVVDGAFSYLQK	SLC2A13	221	Q96QE2
TGLGTFYFLKIANFS	TAS2R14	101	Q9NYV8
LGIAAFYFSQGTSKA	SYNDIG1L	176	A6NDD5
AGFGVLIAFASYNKF	SLC6A2	321	P23975
GNVFVAFAVSYFKAL	TAAR5	51	O14804
SGKSNFFYAIQFVLS	SMC3	36	Q9UQE7
DISYFGVGGKQAVFF	SMCHD1	231	A6NHR9
FAFLSSFVQGYGFFL	SV2C	231	Q496J9
AGFAAFLGKYLEQQF	SLCO3A1	366	Q9UIG8
NYLEFGLETGFTNFS	TMEM161B	191	Q8NDZ6
AYFFTESEGFAGSRK	LMBR1L	131	Q6UX01
SYFVILNSAAFFKVG	NXPE3	106	Q969Y0
ERGCLSQFFGEYKSF	PHF7	126	Q9BWX1
QSLYVENRAGFFFTK	RGS22	666	Q8NE09
SGVVKFYGSFAFNRK	TAF2	526	Q6P1X5
YLFQDAFIFKSDVGF	FASTKD2	76	Q9NYY8
FSTSAFGAYFKLTQG	SLC2A8	331	Q9NY64
AEEYLSFFQFGGQSL	PSD4	621	Q8NDX1
GSLQGDDDKIYFFFS	SEMA4B	251	Q9NPR2
GISFQSKYLSFFILG	SLCO6A1	221	Q86UG4
DFGNYLFNFASAATK	SYAP1	56	Q96A49
LGGLRFFSTQYKDEF	TEX45	441	Q8NA69
KFGFDPFISTNIQYF	PDK3	136	Q15120
AFFSSFVQGYGTFLF	SV2A	246	Q7L0J3
VNGFGLFGIYKSDFD	B4GALNT4	961	Q76KP1
KSFEGLFYFLGSIVN	CLTC	706	Q00610
LEGFNNYTFLSNGFV	MYH11	301	P35749
FDGRVYDNFKTGTFV	VWDE	436	Q8N2E2
AFQYDGRKFDNFGFG	RALGAPA1	916	Q6GYQ0
TESIFIQNSKLYFFG	SLC35A5	261	Q9BS91
IQNSKLYFFGILFNG	SLC35A5	266	Q9BS91
SIKELYGAFAFSANF	SERPINA11	156	Q86U17
AFTANFFKGLEIYQT	RYR3	4386	Q15413
KFLLNFGTVSFYLGY	UBA5	271	Q9GZZ9
FGVLIAFSSYNKFTN	SLC6A3	326	Q01959
AFAGLAFASFYLAGK	PLPP5	156	Q8NEB5
RFFQKGQGTCFYFGE	TRPV2	196	Q9Y5S1
LFYNKENFQLGAFLG	TMEM135	291	Q86UB9
FTFNLGFSGKFYHTG	NDST2	351	P52849
SGNTFFYFLTSFVGL	SEC63	11	Q9UGP8
NHFYGNDGKTTFIFT	PIGN	246	O95427
FEFNGQSGYLLKHEF	PLCB2	646	Q00722
NATGDGKFIDQFVYS	NSD3	511	Q9BZ95
LVNFEESQTFFGLYK	FASLG	266	P48023
FLANSVALFYNFGKS	ZDHHC17	391	Q8IUH5
SFFENKYGNLDIFST	YME1L1	161	Q96TA2
QNKFYSGTGFKFLPF	ATP6V0A1	811	Q93050
SSFYLPGFVKFFGNL	PSMD5	266	Q16401
GQFKSLAFYLLFTGA	TMEM72	36	A0PK05
KLFGTFQQFGSSYDT	USP34	926	Q70CQ2
FIASFFKPGFEKYNN	ZFC3H1	1696	O60293
SKGYAFINFASFDAS	SF3B4	141	Q15427
FAQGKFNGVGVFIRY	MORN4	66	Q8NDC4