Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	chromatin binding	SREBF2 PKNOX1 PHC3 ZNF609 TOX4 EP400 CLOCK EP300 PHC1	2.83e-06	739	34	9	GO:0003682
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SREBF2 NFYC PKNOX1 BPTF SP2 CDC5L CLOCK EP300 CREB5 NR1H4 ZNF256	1.81e-05	1459	34	11	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SREBF2 NFYC PKNOX1 BPTF SP2 CLOCK EP300 CREB5 NR1H4 ZNF256	2.81e-05	1244	34	10	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	SREBF2 NFYC PKNOX1 BPTF SP2 CLOCK EP300 CREB5 NR1H4 ZNF256	3.38e-05	1271	34	10	GO:0000987
GeneOntologyMolecularFunction	protein antigen binding	EP400 EP300	3.33e-04	16	34	2	GO:1990405
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SREBF2 NFYC PKNOX1 SP2 CDC5L CLOCK CREB5 NR1H4 ZNF256	4.48e-04	1412	34	9	GO:0000981
GeneOntologyMolecularFunction	zinc ion binding	CIZ1 PHC3 CPSF4 EP300 NR1H4 PHC1 SEC24B	6.43e-04	891	34	7	GO:0008270
GeneOntologyMolecularFunction	histone binding	BPTF PHC3 PIH1D1 PHC1	1.03e-03	265	34	4	GO:0042393
GeneOntologyMolecularFunction	transcription factor binding	BPTF CDC5L CLOCK EP300 ARID2 NR1H4	1.54e-03	753	34	6	GO:0008134
GeneOntologyMolecularFunction	transcription coregulator binding	CDC5L EP300 NR1H4	1.72e-03	140	34	3	GO:0001221
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	NFYC CDC5L CLOCK CREB5 NR1H4	2.42e-03	560	34	5	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	NFYC CDC5L CLOCK CREB5 NR1H4	2.53e-03	566	34	5	GO:0001216
GeneOntologyMolecularFunction	chromatin DNA binding	TOX4 CLOCK EP300	2.84e-03	167	34	3	GO:0031490
GeneOntologyMolecularFunction	transition metal ion binding	CIZ1 PHC3 CPSF4 EP300 NR1H4 PHC1 SEC24B	3.40e-03	1189	34	7	GO:0046914
GeneOntologyMolecularFunction	histone acetyltransferase activity	CLOCK EP300	3.41e-03	51	34	2	GO:0004402
GeneOntologyMolecularFunction	peptide-lysine-N-acetyltransferase activity	CLOCK EP300	3.95e-03	55	34	2	GO:0061733
GeneOntologyMolecularFunction	peptide N-acetyltransferase activity	CLOCK EP300	4.68e-03	60	34	2	GO:0034212
GeneOntologyMolecularFunction	E-box binding	SREBF2 CLOCK	4.84e-03	61	34	2	GO:0070888
GeneOntologyMolecularFunction	N-acetyltransferase activity	CLOCK EP300	7.79e-03	78	34	2	GO:0008080
GeneOntologyMolecularFunction	promoter-specific chromatin binding	ZNF609 EP300	8.79e-03	83	34	2	GO:1990841
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	SREBF2 NFYC PKNOX1 BPTF TSC22D1 ZNF609 CDC5L CLOCK EP300 CREB5 ARID2 NR1H4	1.14e-06	1390	34	12	GO:0045944
GeneOntologyBiologicalProcess	chromatin remodeling	TDRD5 BPTF EP400 PIH1D1 CLOCK EP300 ARID2 LIN54 PHC1	2.22e-06	741	34	9	GO:0006338
GeneOntologyBiologicalProcess	chromatin organization	TDRD5 BPTF EP400 PIH1D1 CLOCK EP300 ARID2 LIN54 PHC1	1.04e-05	896	34	9	GO:0006325
GeneOntologyBiologicalProcess	protein-DNA complex organization	TDRD5 BPTF EP400 PIH1D1 CLOCK EP300 ARID2 LIN54 PHC1	2.48e-05	999	34	9	GO:0071824
GeneOntologyBiologicalProcess	positive regulation of cellular response to transforming growth factor beta stimulus	TSC22D1 EP300 FURIN	2.58e-05	35	34	3	GO:1903846
GeneOntologyBiologicalProcess	positive regulation of transforming growth factor beta receptor signaling pathway	TSC22D1 EP300 FURIN	2.58e-05	35	34	3	GO:0030511
GeneOntologyBiologicalProcess	coronary artery morphogenesis	ARID2 SEC24B	1.18e-04	10	34	2	GO:0060982
GeneOntologyCellularComponent	nuclear protein-containing complex	NFYC BPTF PHC3 CPSF4 CDC5L EP400 CLOCK UBAP2L ARID2 NR1H4 AHCTF1 LIN54 PHC1 NUP54	1.08e-08	1377	34	14	GO:0140513
GeneOntologyCellularComponent	chromatin	SREBF2 NFYC PKNOX1 BPTF SP2 TOX4 EP400 CLOCK EP300 CREB5 ARID2 NR1H4 AHCTF1 PHC1	2.71e-08	1480	34	14	GO:0000785
GeneOntologyCellularComponent	transcription regulator complex	NFYC PKNOX1 CLOCK EP300 ARID2 NR1H4 LIN54	4.07e-05	596	34	7	GO:0005667
GeneOntologyCellularComponent	nuclear chromosome	SHOC1 CDC5L EP400 CLOCK ADD3	5.31e-05	254	34	5	GO:0000228
GeneOntologyCellularComponent	PcG protein complex	PHC3 UBAP2L PHC1	8.23e-05	52	34	3	GO:0031519
GeneOntologyCellularComponent	chromatoid body	TDRD5 CLOCK	3.44e-04	17	34	2	GO:0033391
GeneOntologyCellularComponent	PRC1 complex	PHC3 PHC1	4.32e-04	19	34	2	GO:0035102
GeneOntologyCellularComponent	SWI/SNF superfamily-type complex	BPTF EP400 ARID2	5.07e-04	96	34	3	GO:0070603
GeneOntologyCellularComponent	ATPase complex	BPTF EP400 ARID2	1.19e-03	129	34	3	GO:1904949
GeneOntologyCellularComponent	condensed chromosome	SHOC1 ARID2 AHCTF1 ADD3	1.49e-03	307	34	4	GO:0000793
GeneOntologyCellularComponent	nuclear ubiquitin ligase complex	PHC3 PHC1	2.88e-03	49	34	2	GO:0000152
Domain	Znf_FCS	PHC3 PHC1	2.83e-05	5	32	2	IPR012313
Domain	ZF_FCS	PHC3 PHC1	4.25e-05	6	32	2	PS51024
Domain	Bromodomain_CS	BPTF EP300	9.01e-04	26	32	2	IPR018359
Domain	ZINC_FINGER_C2H2_1	CIZ1 SP2 ZNF609 CREB5 ARID2 ZNF256	1.82e-03	777	32	6	PS00028
Domain	BROMODOMAIN_1	BPTF EP300	1.82e-03	37	32	2	PS00633
Domain	MYB_LIKE	CDC5L EP400	1.92e-03	38	32	2	PS50090
Domain	Bromodomain	BPTF EP300	1.92e-03	38	32	2	PF00439
Domain	Znf_C2H2-like	CIZ1 SP2 ZNF609 CREB5 ARID2 ZNF256	2.06e-03	796	32	6	IPR015880
Domain	Znf_C2H2	CIZ1 SP2 ZNF609 CREB5 ARID2 ZNF256	2.18e-03	805	32	6	IPR007087
Domain	ZnF_C2H2	CIZ1 SP2 ZNF609 CREB5 ARID2 ZNF256	2.22e-03	808	32	6	SM00355
Domain	BROMODOMAIN_2	BPTF EP300	2.24e-03	41	32	2	PS50014
Domain	BROMO	BPTF EP300	2.35e-03	42	32	2	SM00297
Domain	Bromodomain	BPTF EP300	2.35e-03	42	32	2	IPR001487
Domain	-	BPTF EP300	2.35e-03	42	32	2	1.20.920.10
Domain	SANT	CDC5L EP400	3.31e-03	50	32	2	SM00717
Domain	SANT/Myb	CDC5L EP400	3.57e-03	52	32	2	IPR001005
Domain	SAM_1	PHC3 PHC1	6.04e-03	68	32	2	PF00536
Domain	ZINC_FINGER_C2H2_2	SP2 ZNF609 CREB5 ARID2 ZNF256	9.64e-03	775	32	5	PS50157
Domain	SAM	PHC3 PHC1	9.93e-03	88	32	2	SM00454
Pathway	REACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN	PHC3 EP300 ARID2 PHC1	6.75e-07	37	27	4	M27797
Pathway	REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA	SREBF2 NFYC CLOCK EP300 NR1H4	2.63e-06	118	27	5	M27316
Pathway	REACTOME_SUMOYLATION	PHC3 EP300 NR1H4 PHC1 NUP54	1.52e-05	169	27	5	MM14919
Pathway	REACTOME_SUMOYLATION	PHC3 EP300 NR1H4 PHC1 NUP54	2.61e-05	189	27	5	M27214
Pathway	REACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN	PHC3 EP300 PHC1	3.60e-05	34	27	3	MM15531
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS	PHC3 EP300 PHC1	5.91e-05	40	27	3	MM15000
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS	PHC3 EP300 PHC1	7.88e-05	44	27	3	M27295
Pathway	REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS	PHC3 PHC1 NUP54	9.61e-05	47	27	3	M27395
Pathway	REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF	SREBF2 NFYC SEC24B	1.54e-04	55	27	3	M27001
Pathway	REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS	PHC3 PHC1 NUP54	1.80e-04	58	27	3	MM15149
Pathway	REACTOME_METABOLISM_OF_STEROIDS	SREBF2 NFYC NR1H4 SEC24B	1.98e-04	154	27	4	M27832
Pathway	REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS	PHC3 PHC1 NUP54	2.53e-04	65	27	3	MM15147
Pathway	REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS	PHC3 PHC1 NUP54	3.28e-04	71	27	3	M27394
Pathway	REACTOME_SUMOYLATION_OF_DNA_METHYLATION_PROTEINS	PHC3 PHC1	4.17e-04	16	27	2	M27403
Pathway	REACTOME_POLO_LIKE_KINASE_MEDIATED_EVENTS	EP300 LIN54	4.17e-04	16	27	2	M26971
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_DEATH_GENES	NFYC EP300	4.17e-04	16	27	2	M27940
Pathway	REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS	PHC3 PHC1 NUP54	4.17e-04	77	27	3	M27226
Pathway	REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS	PHC3 PHC1 NUP54	5.38e-04	84	27	3	MM14929
Pathway	REACTOME_CELLULAR_RESPONSES_TO_STIMULI	NFYC PHC3 EP400 CLOCK EP300 PHC1 NUP54	7.41e-04	828	27	7	M27827
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	NFYC PHC3 CPSF4 EP300 ARID2 NR1H4 FURIN PHC1 ZNF256	7.64e-04	1387	27	9	M734
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1	PHC3 EP300 ARID2 PHC1	1.01e-03	237	27	4	M27786
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_E2F6	PHC3 PHC1	1.03e-03	25	27	2	MM15546
Pathway	KEGG_MEDICUS_REFERENCE_DEUBIQUITINATION_OF_H2AK119	PHC3 PHC1	1.12e-03	26	27	2	M47923
Pathway	REACTOME_POSTMITOTIC_NUCLEAR_PORE_COMPLEX_NPC_REFORMATION	AHCTF1 NUP54	1.20e-03	27	27	2	M29807
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	EP400 CLOCK EP300 ARID2	1.68e-03	272	27	4	M29619
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_E2F6	PHC3 PHC1	1.91e-03	34	27	2	M27826
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	CIZ1 NFYC PKNOX1 BPTF SP2 TSC22D1 CPSF4 ZNF609 TOX4 CDC5L CLOCK ARID2 AHCTF1 PHC1	1.76e-14	808	35	14	20412781
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	CIZ1 BPTF TOX4 CDC5L ALMS1 EP400 UBAP2L EP300 ARID2 AHCTF1 ADD3 SEC24B	1.27e-13	549	35	12	38280479
Pubmed	Human transcription factor protein interaction networks.	NFYC BPTF SP2 PHC3 CPSF4 ZNF609 ALMS1 EP400 UBAP2L EP300 ARID2 LIN54 NUP54 SEC24B	3.79e-11	1429	35	14	35140242
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	CIZ1 PHC3 TOX4 CDC5L ALMS1 EP400 PIH1D1 UBAP2L ARID2 AHCTF1 ADD3 SEC24B	6.20e-11	934	35	12	33916271
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	CIZ1 BPTF SP2 PHC3 CPSF4 ZNF609 TOX4 CDC5L EP400 CLOCK EP300 AHCTF1 LIN54	1.70e-10	1294	35	13	30804502
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	PKNOX1 BPTF CPSF4 CDC5L EP400 EP300 AHCTF1 PHC1 NUP54	2.22e-10	411	35	9	35182466
Pubmed	A census of human transcription factors: function, expression and evolution.	SREBF2 NFYC PKNOX1 SP2 TSC22D1 TOX4 CDC5L CLOCK CREB5 NR1H4 AHCTF1	8.51e-10	908	35	11	19274049
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CIZ1 BPTF PHC3 ZNF609 TOX4 CDC5L EP400 UBAP2L ARID2 AHCTF1 LIN54	1.43e-09	954	35	11	36373674
Pubmed	Interaction network of human early embryonic transcription factors.	BPTF ZNF609 ALMS1 EP400 EP300 ARID2 LIN54 NUP54	1.84e-09	351	35	8	38297188
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	CIZ1 NFYC SP2 PHC3 ZNF609 EP400 EP300 ARID2	4.93e-09	398	35	8	35016035
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	BPTF PHC3 EP400 EP300 ARID2 PHC1	1.12e-08	157	35	6	30186101
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	SP2 ZNF609 CDC5L EP400 UBAP2L LIN54 ADD3 SEC24B	1.15e-08	444	35	8	34795231
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	BPTF CPSF4 CDC5L ALMS1 EP400 UBAP2L AHCTF1	3.76e-07	469	35	7	27634302
Pubmed	A human MAP kinase interactome.	SREBF2 NFYC TSC22D1 TOX4 EP300 ARID2 NUP54	4.78e-07	486	35	7	20936779
Pubmed	Regulon analysis identifies protective FXR and CREB5 in proximal tubules in early diabetic kidney disease.	CREB5 NR1H4	9.84e-07	2	35	2	37337149
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CIZ1 BPTF EP400P1 ZNF609 ALMS1 EP400 EP300 ARID2 AHCTF1	1.16e-06	1116	35	9	31753913
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	BPTF EP400 EP300 LIN54	1.49e-06	83	35	4	28794006
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	CIZ1 BPTF PHC3 ARID2 AHCTF1 LIN54 PHC1	2.12e-06	608	35	7	36089195
Pubmed	SREBP-2 negatively regulates FXR-dependent transcription of FGF19 in human intestinal cells.	SREBF2 NR1H4	2.95e-06	3	35	2	24321096
Pubmed	Epigenetically regulated miR-449a enhances hepatitis B virus replication by targeting cAMP-responsive element binding protein 5 and modulating hepatocytes phenotype.	CREB5 NR1H4	2.95e-06	3	35	2	27138288
Pubmed	Transcription factor Sp2 potentiates binding of the TALE homeoproteins Pbx1:Prep1 and the histone-fold domain protein Nf-y to composite genomic sites.	PKNOX1 SP2	2.95e-06	3	35	2	30337366
Pubmed	Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300.	EP400 EP300	2.95e-06	3	35	2	9590171
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	CIZ1 CCDC66 ALMS1 EP400 UBAP2L EP300 PHC1	3.13e-06	645	35	7	25281560
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	PHC3 ZNF609 TOX4 ALMS1 LIN54 PHC1	3.51e-06	418	35	6	34709266
Pubmed	Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.	BPTF PHC3 EP300 PHC1	5.68e-06	116	35	4	21282530
Pubmed	Binding and modulation of p53 by p300/CBP coactivators.	EP400 EP300	5.90e-06	4	35	2	9194565
Pubmed	CBP/p300 is a cell type-specific modulator of CLOCK/BMAL1-mediated transcription.	CLOCK EP300	5.90e-06	4	35	2	19922678
Pubmed	The p300 acetylase is critical for ligand-activated farnesoid X receptor (FXR) induction of SHP.	EP300 NR1H4	5.90e-06	4	35	2	18842595
Pubmed	SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein.	SREBF2 EP300	5.90e-06	4	35	2	8918891
Pubmed	Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration.	SP2 NR1H4	5.90e-06	4	35	2	17071613
Pubmed	The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage.	SREBF2 SEC24B	5.90e-06	4	35	2	19706601
Pubmed	The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2.	SREBF2 NR1H4	5.90e-06	4	35	2	25593129
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	SP2 PHC3 ZNF609 EP400 CLOCK	9.00e-06	282	35	5	23667531
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SP2 TSC22D1 TOX4 CDC5L ALMS1 ARID2	9.01e-06	493	35	6	15368895
Pubmed	Interactions between p300 and multiple NF-Y trimers govern cyclin B2 promoter function.	NFYC EP300	9.82e-06	5	35	2	12482752
Pubmed	FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states.	EP300 NR1H4	9.82e-06	5	35	2	19883617
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	BPTF ZNF609 EP400 PHC1	1.41e-05	146	35	4	23892456
Pubmed	Coactivation of the CLOCK-BMAL1 complex by CBP mediates resetting of the circadian clock.	CLOCK EP300	1.47e-05	6	35	2	20930143
Pubmed	Degradation, Promoter Recruitment and Transactivation Mediated by the Extreme N-Terminus of MHC Class II Transactivator CIITA Isoform III.	EP400 EP300	1.47e-05	6	35	2	26871568
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	SREBF2 PKNOX1 SP2 CPSF4 CLOCK CREB5	1.57e-05	544	35	6	28473536
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	CIZ1 ZNF609 ALMS1 EP300	1.65e-05	152	35	4	38360978
Pubmed	p73 competes with co-activators and recruits histone deacetylase to NF-Y in the repression of PDGF beta-receptor.	NFYC EP300	2.06e-05	7	35	2	15454570
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	CPSF4 TOX4 CDC5L EP400 LIN54	2.18e-05	339	35	5	30415952
Pubmed	Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic Escherichia coli Type III Secretion System Effectors.	EP300 SEC24B	2.74e-05	8	35	2	27018634
Pubmed	Generation and analysis of 280,000 human expressed sequence tags.	PKNOX1 CPSF4 PIH1D1 ODAM EP300	3.23e-05	368	35	5	8889549
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	BPTF SP2 CDC5L AHCTF1 ADD3	3.31e-05	370	35	5	22922362
Pubmed	NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes.	NFYC EP300	4.40e-05	10	35	2	15601870
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	BPTF ZNF609 CDC5L EP400 PHC1	4.57e-05	396	35	5	26687479
Pubmed	Genetic interaction mapping in mammalian cells using CRISPR interference.	PHC3 EP400 PHC1	4.67e-05	69	35	3	28481362
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	PHC3 CPSF4 TOX4 EP400 UBAP2L AHCTF1 CSNK1G1 ADD3	5.19e-05	1371	35	8	36244648
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	CIZ1 BPTF CPSF4 CDC5L EP400 UBAP2L NUP54	6.14e-05	1024	35	7	24711643
Pubmed	Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.	CLOCK EP300	6.45e-05	12	35	2	14645221
Pubmed	Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.	PHC3 PHC1	6.45e-05	12	35	2	19636380
Pubmed	Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.	PKNOX1 CLOCK ARID2	6.49e-05	77	35	3	19505873
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	SREBF2 PKNOX1 SP2 CPSF4 TOX4 PHC1	6.89e-05	709	35	6	22988430
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	ZNF609 CDC5L EP300 ARID2	6.99e-05	220	35	4	35785414
Pubmed	BMI1-UBR5 axis regulates transcriptional repression at damaged chromatin.	UBAP2L PHC1	7.62e-05	13	35	2	27647897
Pubmed	Essential role of MESP1-RING1A complex in cardiac differentiation.	EP300 PHC1	1.02e-04	15	35	2	36413948
Pubmed	Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit.	EP300 NR1H4	1.02e-04	15	35	2	14701856
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	ZNF609 TOX4 CDC5L ARID2	1.04e-04	244	35	4	29884807
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	BPTF ZNF609 EP400 PIH1D1 ARID2	1.05e-04	472	35	5	38943005
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	EP400 PIH1D1 FURIN LIN54 ADD3 SEC24B	1.14e-04	777	35	6	35844135
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	BPTF CPSF4 TOX4 CDC5L	1.16e-04	251	35	4	31076518
Pubmed	Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules.	PKNOX1 EP300	1.17e-04	16	35	2	22780989
Pubmed	The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.	PHC3 PHC1	1.17e-04	16	35	2	12167701
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	BPTF CDC5L ALMS1 UBAP2L SEC24B	1.29e-04	494	35	5	26831064
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	CIZ1 ZNF609 TOX4 CDC5L ARID2 AHCTF1 LIN54	1.30e-04	1155	35	7	20360068
Pubmed	SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.	PKNOX1 CDC5L AHCTF1 PHC1	1.31e-04	259	35	4	30404004
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	CPSF4 ZNF609 EP400 LIN54	1.50e-04	268	35	4	33640491
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	BPTF TOX4 EP400 AHCTF1	1.56e-04	271	35	4	32433965
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ZNF609 ALMS1 CLOCK	1.59e-04	104	35	3	9205841
Pubmed	HIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic intervention.	EP300 NUP54	1.66e-04	19	35	2	21489275
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	BPTF TOX4 EP400 AHCTF1	1.84e-04	283	35	4	30585729
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	NFYC BPTF EP400 EP300 CREB5 LIN54	1.94e-04	857	35	6	25609649
Pubmed	SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.	PHC3 PHC1	2.04e-04	21	35	2	37014752
Pubmed	PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos.	PHC3 PHC1	2.04e-04	21	35	2	18311137
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	SREBF2 PKNOX1 SP2 CDC5L CLOCK EP300	2.20e-04	877	35	6	20211142
Pubmed	Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).	SREBF2 NFYC	2.24e-04	22	35	2	20965718
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	CDC5L ALMS1 NUP54	2.42e-04	120	35	3	31413325
Pubmed	P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma.	EP400 EP300	2.91e-04	25	35	2	36708875
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	SP2 TOX4 CDC5L EP400 UBAP2L AHCTF1 LIN54	2.93e-04	1318	35	7	30463901
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	ALMS1 EP400 UBAP2L	3.06e-04	130	35	3	12421765
Pubmed	Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.	NFYC TDRD5 BPTF ALMS1	3.15e-04	326	35	4	17015433
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	CDC5L EP400 LIN54	3.34e-04	134	35	3	25452129
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	SHOC1 TOX4 EP300 AHCTF1	3.38e-04	332	35	4	37433992
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	BPTF EP400 UBAP2L ARID2	3.38e-04	332	35	4	32786267
Pubmed	Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein.	UBAP2L EP300	3.40e-04	27	35	2	18838386
Pubmed	NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.	BPTF ZNF609	3.40e-04	27	35	2	23395962
Pubmed	Vpr and its interactions with cellular proteins.	EP300 NUP54	3.66e-04	28	35	2	20012529
Pubmed	High glucose mediates the ChREBP/p300 transcriptional complex to activate proapoptotic genes Puma and BAX and contributes to intervertebral disc degeneration.	EP300 NR1H4	3.93e-04	29	35	2	34461288
Pubmed	RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.	UBAP2L ARID2	3.93e-04	29	35	2	36800290
Pubmed	Integrated structural analysis of the human nuclear pore complex scaffold.	AHCTF1 NUP54	4.20e-04	30	35	2	24315095
Pubmed	The Structure Inventory of the Nuclear Pore Complex.	AHCTF1 NUP54	4.20e-04	30	35	2	27016207
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	BPTF CDC5L EP400	4.65e-04	150	35	3	28242625
Pubmed	Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage.	PIH1D1 AHCTF1 LIN54	5.21e-04	156	35	3	37108203
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	SREBF2 BPTF EP400P1 TSC22D1 ZNF609 UBAP2L EP300	6.09e-04	1489	35	7	28611215
Pubmed	The protein interaction landscape of the human CMGC kinase group.	CPSF4 ALMS1 EP400 UBAP2L EP300	6.21e-04	695	35	5	23602568
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CIZ1 PHC3 CPSF4 EP400 ARID2 AHCTF1 SEC24B	6.29e-04	1497	35	7	31527615
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	BPTF EP400 PHC1	6.36e-04	167	35	3	20362541
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	CIZ1 CDC5L EP400 ARID2	6.43e-04	394	35	4	27248496
Interaction	WWTR1 interactions	BPTF TOX4 CDC5L ALMS1 EP400 CLOCK EP300 ARID2 AHCTF1 ADD3 SEC24B	7.92e-11	422	35	11	int:WWTR1
Interaction	NFYC interactions	SREBF2 NFYC SP2 ALMS1 EP400 ARID2 LIN54 NUP54	5.81e-10	177	35	8	int:NFYC
Interaction	FHL2 interactions	SREBF2 NFYC PKNOX1 SP2 PHC3 ALMS1 EP400 ODAM EP300	1.79e-08	396	35	9	int:FHL2
Interaction	KLF15 interactions	NFYC SP2 ZNF609 EP400 EP300 ARID2 LIN54 ADD3	2.80e-08	290	35	8	int:KLF15
Interaction	NAA40 interactions	CIZ1 PHC3 TOX4 CDC5L ALMS1 EP400 PIH1D1 UBAP2L ARID2 AHCTF1 ADD3 SEC24B	4.72e-08	978	35	12	int:NAA40
Interaction	FEV interactions	SP2 PHC3 ZNF609 EP400 EP300 ARID2 LIN54	5.02e-08	203	35	7	int:FEV
Interaction	PAX6 interactions	NFYC PKNOX1 BPTF ZNF609 EP400 EP300 ARID2 LIN54	1.68e-07	366	35	8	int:PAX6
Interaction	HNF4A interactions	SREBF2 BPTF ZNF609 EP400 EP300 ARID2 LIN54	3.96e-07	275	35	7	int:HNF4A
Interaction	SMC5 interactions	CIZ1 BPTF PHC3 ZNF609 TOX4 CDC5L EP400 UBAP2L ARID2 AHCTF1 LIN54	5.91e-07	1000	35	11	int:SMC5
Interaction	SOX9 interactions	PHC3 ZNF609 EP400 EP300 ARID2	6.74e-07	97	35	5	int:SOX9
Interaction	HNF1B interactions	BPTF ZNF609 EP400 EP300 ARID2 LIN54	8.39e-07	190	35	6	int:HNF1B
Interaction	NUP43 interactions	CIZ1 BPTF PHC3 ZNF609 EP400 ARID2 AHCTF1 LIN54 NUP54	8.59e-07	625	35	9	int:NUP43
Interaction	ELF4 interactions	BPTF SP2 EP400 ARID2 LIN54	1.57e-06	115	35	5	int:ELF4
Interaction	KLF3 interactions	BPTF ZNF609 EP400 EP300 ARID2 LIN54	2.42e-06	228	35	6	int:KLF3
Interaction	ELF1 interactions	NFYC BPTF EP400 ARID2 LIN54	2.46e-06	126	35	5	int:ELF1
Interaction	XRCC6 interactions	NFYC BPTF TOX4 EP400 PIH1D1 EP300 NR1H4 FURIN AHCTF1 LIN54	2.62e-06	928	35	10	int:XRCC6
Interaction	TERF2IP interactions	CIZ1 BPTF PHC3 ZNF609 EP400 AHCTF1 LIN54 PHC1	3.69e-06	552	35	8	int:TERF2IP
Interaction	SRF interactions	NFYC BPTF SP2 PHC3 ARID2	3.99e-06	139	35	5	int:SRF
Interaction	GATA4 interactions	BPTF CPSF4 EP400 EP300 AHCTF1 PHC1 NUP54	5.73e-06	411	35	7	int:GATA4
Interaction	PELO interactions	SREBF2 CDC5L PIH1D1 EP300 NUP54	8.18e-06	161	35	5	int:PELO
Interaction	PARP1 interactions	CIZ1 SREBF2 NFYC PKNOX1 BPTF PHC3 CDC5L EP400 PIH1D1 EP300 PHC1	8.56e-06	1316	35	11	int:PARP1
Interaction	BAG2 interactions	CIZ1 NFYC BPTF PHC3 ZNF609 CDC5L EP300 PHC1	8.86e-06	622	35	8	int:BAG2
Interaction	YY1 interactions	BPTF PHC3 TOX4 EP400 EP300 ARID2 LIN54	1.10e-05	454	35	7	int:YY1
Interaction	SP7 interactions	CPSF4 ZNF609 EP400 EP300 ARID2 LIN54	1.26e-05	304	35	6	int:SP7
Interaction	H3C3 interactions	CIZ1 BPTF PHC3 ARID2 AHCTF1 LIN54 PHC1	1.91e-05	495	35	7	int:H3C3
Interaction	KLF8 interactions	BPTF ZNF609 EP400 EP300 ARID2 LIN54	1.97e-05	329	35	6	int:KLF8
Interaction	PML interactions	SP2 ZNF609 CDC5L EP400 UBAP2L EP300 LIN54 ADD3 SEC24B	2.23e-05	933	35	9	int:PML
Interaction	KDM1A interactions	PHC3 ZNF609 CDC5L ALMS1 EP400 CLOCK EP300 LIN54 PHC1	2.39e-05	941	35	9	int:KDM1A
Interaction	NUDT21 interactions	SREBF2 TOX4 CDC5L PIH1D1 UBAP2L EP300	3.75e-05	369	35	6	int:NUDT21
Interaction	APEX1 interactions	CIZ1 SREBF2 BPTF CCDC66 EP400 PIH1D1 EP300 ARID2 AHCTF1 LIN54	4.12e-05	1271	35	10	int:APEX1
Interaction	TLE3 interactions	PHC3 ZNF609 CLOCK EP300 ARID2 NUP54	4.16e-05	376	35	6	int:TLE3
Interaction	NFIX interactions	BPTF ZNF609 EP400 ARID2 LIN54	4.28e-05	227	35	5	int:NFIX
Interaction	MEX3A interactions	SREBF2 SHOC1 TOX4 UBAP2L EP300 AHCTF1	4.68e-05	384	35	6	int:MEX3A
Interaction	H2BC8 interactions	CIZ1 BPTF PHC3 EP400 AHCTF1 LIN54 PHC1	5.04e-05	576	35	7	int:H2BC8
Interaction	POU5F1 interactions	NFYC BPTF TOX4 CDC5L EP400 UBAP2L PHC1	5.49e-05	584	35	7	int:POU5F1
Interaction	ETS1 interactions	BPTF EP400 EP300 ARID2	5.61e-05	121	35	4	int:ETS1
Interaction	EYA4 interactions	CIZ1 ZNF609 ALMS1 EP300 SEC24B	5.91e-05	243	35	5	int:EYA4
Interaction	ACTB interactions	PKNOX1 CCDC66 CDC5L ALMS1 EP400 PIH1D1 EP300 ARID2 ADD3	7.18e-05	1083	35	9	int:ACTB
Interaction	CRX interactions	NFYC ZNF609 EP400 EP300 ARID2	7.29e-05	254	35	5	int:CRX
Interaction	FOXP3 interactions	BPTF SP2 CDC5L EP300 AHCTF1 ADD3	8.98e-05	432	35	6	int:FOXP3
Interaction	SNRNP40 interactions	CIZ1 PHC3 ZNF609 CDC5L EP400 ARID2 AHCTF1	9.48e-05	637	35	7	int:SNRNP40
Interaction	SOX2 interactions	BPTF SP2 PHC3 CPSF4 ZNF609 EP400 CLOCK EP300 ARID2 LIN54	1.06e-04	1422	35	10	int:SOX2
Interaction	SMAD3 interactions	SREBF2 NFYC PKNOX1 BPTF EP300 FURIN	1.08e-04	447	35	6	int:SMAD3
Interaction	CEBPB interactions	NFYC BPTF PHC3 CPSF4 CDC5L PIH1D1 UBAP2L EP300 CREB5 AHCTF1	1.20e-04	1443	35	10	int:CEBPB
Interaction	EED interactions	SREBF2 BPTF PHC3 TSC22D1 CPSF4 CDC5L EP400 AHCTF1 PHC1 SEC24B	1.22e-04	1445	35	10	int:EED
Interaction	SUMO1 interactions	SREBF2 CDC5L EP300 NR1H4 PHC1	1.29e-04	287	35	5	int:SUMO1
Interaction	SMARCA4 interactions	BPTF CDC5L EP400 EP300 ARID2 NR1H4	1.30e-04	462	35	6	int:SMARCA4
Interaction	MESP1 interactions	EP300 PHC1	1.31e-04	10	35	2	int:MESP1
Interaction	TFAP4 interactions	PKNOX1 BPTF CLOCK ARID2	1.39e-04	153	35	4	int:TFAP4
Interaction	NUP155 interactions	CDC5L ALMS1 PIH1D1 AHCTF1 NUP54 SEC24B	1.54e-04	477	35	6	int:NUP155
Interaction	NANOG interactions	BPTF ZNF609 EP400 EP300 AHCTF1 PHC1	1.62e-04	481	35	6	int:NANOG
Interaction	PPP1CA interactions	TOX4 CDC5L PIH1D1 CLOCK EP300 AHCTF1 PHC1	1.64e-04	696	35	7	int:PPP1CA
Interaction	H2BC21 interactions	BPTF TOX4 EP400 EP300 ARID2 AHCTF1 PHC1	1.64e-04	696	35	7	int:H2BC21
Interaction	POLR1G interactions	CIZ1 BPTF PHC3 EP400 PIH1D1 LIN54	1.77e-04	489	35	6	int:POLR1G
Interaction	SELENOP interactions	EP400 EP300	1.91e-04	12	35	2	int:SELENOP
Interaction	PPP1R3A interactions	TOX4 PIH1D1 EP300	1.95e-04	65	35	3	int:PPP1R3A
Interaction	GARRE1 interactions	ALMS1 UBAP2L NUP54 SEC24B	1.95e-04	167	35	4	int:GARRE1
Interaction	EGR2 interactions	ZNF609 EP400 EP300 ARID2	2.13e-04	171	35	4	int:EGR2
Interaction	TLX1 interactions	PKNOX1 ZNF609 EP300 LIN54	2.33e-04	175	35	4	int:TLX1
Interaction	TEAD1 interactions	BPTF ZNF609 EP300 ARID2	2.38e-04	176	35	4	int:TEAD1
Interaction	AR interactions	CPSF4 ZNF609 CDC5L EP400 UBAP2L EP300 ARID2 LIN54	2.40e-04	992	35	8	int:AR
Interaction	EGR1 interactions	SREBF2 EP300 ARID2	2.64e-04	72	35	3	int:EGR1
Interaction	ELP1 interactions	TSC22D1 CDC5L PIH1D1 EP300	2.71e-04	182	35	4	int:ELP1
Interaction	LHX2 interactions	ZNF609 EP400 ARID2 LIN54	2.76e-04	183	35	4	int:LHX2
Interaction	MYOD1 interactions	BPTF ZNF609 EP400 EP300	3.45e-04	194	35	4	int:MYOD1
Interaction	KLF5 interactions	ZNF609 EP400 EP300 ARID2	3.52e-04	195	35	4	int:KLF5
Interaction	SOX7 interactions	ZNF609 EP300 ARID2	3.87e-04	82	35	3	int:SOX7
Interaction	IRF1 interactions	SP2 EP300 ARID2	4.01e-04	83	35	3	int:IRF1
Interaction	SF3B1 interactions	TOX4 CDC5L PIH1D1 UBAP2L EP300 PHC1	4.06e-04	571	35	6	int:SF3B1
Interaction	TPX2 interactions	BPTF CDC5L EP300 CSNK1G1	4.17e-04	204	35	4	int:TPX2
Interaction	GOLGB1 interactions	SREBF2 CDC5L PIH1D1 FURIN	4.25e-04	205	35	4	int:GOLGB1
Interaction	IRF4 interactions	ZNF609 EP300 ARID2	4.30e-04	85	35	3	int:IRF4
Interaction	SEC24C interactions	CDC5L PIH1D1 EP300 SEC24B	4.41e-04	207	35	4	int:SEC24C
Interaction	YAP1 interactions	CIZ1 BPTF TOX4 UBAP2L EP300 ARID2 AHCTF1 ADD3	4.68e-04	1095	35	8	int:YAP1
Interaction	ZP3 interactions	UBAP2L FURIN	4.92e-04	19	35	2	int:ZP3
Interaction	DBP interactions	CLOCK EP300	4.92e-04	19	35	2	int:DBP
Interaction	HDAC1 interactions	NFYC BPTF ZNF609 TOX4 ALMS1 EP400 EP300 NUP54	5.06e-04	1108	35	8	int:HDAC1
Interaction	SOX10 interactions	ZNF609 EP300 ARID2	5.42e-04	92	35	3	int:SOX10
Interaction	KLF11 interactions	NFYC EP300	5.46e-04	20	35	2	int:KLF11
Interaction	POU3F2 interactions	NFYC EP300	5.46e-04	20	35	2	int:POU3F2
Interaction	MORF4L1 interactions	EP400P1 CDC5L EP400 EP300	5.64e-04	221	35	4	int:MORF4L1
Interaction	HDLBP interactions	CPSF4 TOX4 CDC5L EP400 PIH1D1 UBAP2L ADD3	5.73e-04	855	35	7	int:HDLBP
Interaction	SEC23B interactions	PIH1D1 EP300 FURIN SEC24B	5.74e-04	222	35	4	int:SEC23B
Interaction	SEC24A interactions	PIH1D1 EP300 FURIN SEC24B	5.94e-04	224	35	4	int:SEC24A
Interaction	KLF13 interactions	SREBF2 EP300	6.03e-04	21	35	2	int:KLF13
Interaction	FIP1L1 interactions	BPTF CPSF4 TOX4 EP300	6.04e-04	225	35	4	int:FIP1L1
Interaction	CTBP1 interactions	PHC3 EP400 EP300 CREB5 FURIN	6.39e-04	406	35	5	int:CTBP1
Interaction	IL1A interactions	BPTF EP300	6.62e-04	22	35	2	int:IL1A
Interaction	L3MBTL2 interactions	CIZ1 NFYC LIN54 PHC1	6.66e-04	231	35	4	int:L3MBTL2
Interaction	TFCP2L1 interactions	BPTF EP400 PHC1	6.71e-04	99	35	3	int:TFCP2L1
Interaction	SEC31A interactions	PIH1D1 EP300 FURIN SEC24B	7.22e-04	236	35	4	int:SEC31A
Interaction	KRT18 interactions	CDC5L ALMS1 PIH1D1 EP300 AHCTF1	7.36e-04	419	35	5	int:KRT18
Interaction	AJUBA interactions	CLOCK EP300 CREB5	7.53e-04	103	35	3	int:AJUBA
Interaction	NUP35 interactions	ZNF609 EP300 FURIN AHCTF1 NUP54	7.77e-04	424	35	5	int:NUP35
Interaction	CBX3 interactions	EP400 PIH1D1 EP300 ARID2 AHCTF1 LIN54	7.78e-04	646	35	6	int:CBX3
Interaction	NFYA interactions	SREBF2 NFYC EP300	7.97e-04	105	35	3	int:NFYA
Interaction	SUB1 interactions	SREBF2 CDC5L PIH1D1 EP300	8.55e-04	247	35	4	int:SUB1
Interaction	BMI1 interactions	CIZ1 PHC3 UBAP2L EP300 PHC1 SEC24B	8.63e-04	659	35	6	int:BMI1
Interaction	ASF1A interactions	EP400 EP300 ARID2 LIN54	8.81e-04	249	35	4	int:ASF1A
Interaction	EN1 interactions	ZNF609 EP400 EP300	9.12e-04	110	35	3	int:EN1
Cytoband	12q24.33	EP400P1 EP400	6.23e-04	48	35	2	12q24.33
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	CLOCK EP300	1.41e-04	17	19	2	486
GeneFamily	Nucleoporins	AHCTF1 NUP54	5.09e-04	32	19	2	1051
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	CDC5L EP400	1.40e-03	53	19	2	532
GeneFamily	Sterile alpha motif domain containing	PHC3 PHC1	3.80e-03	88	19	2	760
GeneFamily	Basic helix-loop-helix proteins	SREBF2 CLOCK	5.86e-03	110	19	2	420
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	SP2 ZNF609 ZNF256	3.76e-02	718	19	3	28
CoexpressionAtlas	facebase_RNAseq_e10.5_MaxArch_2500_K3	NFYC PHC3 CCDC66 ALMS1 UBAP2L CREB5 AHCTF1 LIN54 PHC1	1.15e-04	1252	34	9	facebase_RNAseq_e10.5_MaxArch_2500_K3
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3	NFYC BPTF CCDC66 CDC5L ALMS1 CREB5 AHCTF1 LIN54 PHC1	1.18e-04	1257	34	9	facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlas	facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4	NFYC BPTF SP2 ZNF609 CCDC66 ALMS1 PIH1D1 LIN54 PHC1	2.27e-04	1370	34	9	facebase_RNAseq_e10.5_NeuroEpith_central_2500_K4
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	PHC3 ALMS1 EP300 ARID2 ADD3	3.36e-07	186	35	5	03db813598b67b1e08f759758a1c2023396921fa
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	NFYC PKNOX1 BPTF ZNF609 CLOCK EP300	2.39e-07	173	35	6	2881_DN
Drug	CV-1	SREBF2 PHC3 EP300 CREB5 NR1H4 FURIN	8.09e-07	213	35	6	CID000130105
Drug	Methoxy-6-harmalan [3589-73-9]; Up 200; 18.6uM; HL60; HG-U133A	CPSF4 ZNF609 CDC5L CLOCK UBAP2L	1.24e-05	198	35	5	1743_UP
Drug	Urosiol [128-13-2]; Up 200; 10.2uM; PC3; HT_HG-U133A	PKNOX1 CPSF4 ZNF609 TOX4 CSNK1G1	1.24e-05	198	35	5	7243_UP
Drug	AC1L9K70	NFYC PHC3 ALMS1 EP300 NR1H4	2.45e-05	228	35	5	CID000446871
Drug	MW 1	CIZ1 SREBF2 NFYC EP300	8.29e-05	151	35	4	CID000073965
Drug	1H-inden-1-yl	SP2 CPSF4	1.03e-04	10	35	2	CID005374393
Drug	AC1L2FXT	PHC3 PHC1	1.03e-04	10	35	2	CID000071316
Drug	AC1L2XIZ	PHC3 PHC1	1.50e-04	12	35	2	CID000104803
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	NFYC PKNOX1 BPTF EP300	1.60e-04	179	35	4	5822_DN
Drug	Rifabutin [72559-06-9]; Down 200; 4.8uM; PC3; HT_HG-U133A	CIZ1 NFYC PKNOX1 PHC3	1.74e-04	183	35	4	4527_DN
Drug	Podophyllotoxin [518-28-5]; Up 200; 9.6uM; PC3; HT_HG-U133A	CIZ1 PHC3 CREB5 NR1H4	1.89e-04	187	35	4	5841_UP
Drug	Thioguanosine [85-31-4]; Down 200; 12.6uM; MCF7; HT_HG-U133A	SREBF2 PKNOX1 CLOCK CSNK1G1	2.01e-04	190	35	4	2619_DN
Drug	Corynanthine hydrochloride [66634-44-4]; Down 200; 10.2uM; MCF7; HT_HG-U133A	PKNOX1 TOX4 CDC5L ALMS1	2.05e-04	191	35	4	4811_DN
Drug	Antimycin A [1397-94-0]; Down 200; 7.2uM; PC3; HT_HG-U133A	PKNOX1 BPTF UBAP2L EP300	2.13e-04	193	35	4	2098_DN
Drug	Methazolamide [554-57-4]; Up 200; 17uM; MCF7; HT_HG-U133A	CIZ1 PHC3 ZNF609 ALMS1	2.13e-04	193	35	4	3474_UP
Drug	0316684-0000 [391209-55-5]; Up 200; 10uM; PC3; HT_HG-U133A	CPSF4 ZNF609 ALMS1 UBAP2L	2.13e-04	193	35	4	7057_UP
Drug	Hycanthone [3105-97-3]; Down 200; 11.2uM; PC3; HT_HG-U133A	PHC3 ZNF609 NR1H4 CSNK1G1	2.13e-04	193	35	4	4630_DN
Drug	prazosin hydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A_EA	PHC3 ALMS1 FURIN CSNK1G1	2.18e-04	194	35	4	942_UP
Drug	nordihydroguaiaretic acid; Down 200; 1uM; PC3; HT_HG-U133A	SREBF2 PKNOX1 FURIN CSNK1G1	2.18e-04	194	35	4	1223_DN
Drug	phenanthridinone; Down 200; 51.2uM; MCF7; HT_HG-U133A_EA	ZNF609 ALMS1 EP400 ADD3	2.18e-04	194	35	4	1115_DN
Drug	Diphenidol hydrochloride [3254-89-5]; Down 200; 11.6uM; MCF7; HT_HG-U133A	NFYC PKNOX1 ZNF609 ADD3	2.18e-04	194	35	4	7406_DN
Drug	Memantine Hydrochloride [41100-52-1]; Down 200; 18.6uM; MCF7; HT_HG-U133A	ZNF609 UBAP2L FURIN CSNK1G1	2.18e-04	194	35	4	7354_DN
Drug	Tocainide hydrochloride; Up 200; 17.4uM; MCF7; HT_HG-U133A	CIZ1 ZNF609 TOX4 ADD3	2.18e-04	194	35	4	4838_UP
Drug	Danazol [17230-88-5]; Down 200; 11.8uM; PC3; HG-U133A	CIZ1 ALMS1 UBAP2L ADD3	2.18e-04	194	35	4	1954_DN
Drug	Betamethasone [378-44-9]; Up 200; 10.2uM; MCF7; HT_HG-U133A	SREBF2 PKNOX1 ZNF609 CDC5L	2.18e-04	194	35	4	5328_UP
Drug	haloperidol; Up 200; 10uM; MCF7; HT_HG-U133A_EA	ZNF609 EP400 UBAP2L EP300	2.26e-04	196	35	4	1041_UP
Drug	Tocopherol (R,S) [10191-41-0]; Up 200; 9.2uM; MCF7; HT_HG-U133A	CIZ1 ZNF609 CDC5L FURIN	2.26e-04	196	35	4	3256_UP
Drug	Hesperidin [520-26-3]; Down 200; 6.6uM; HL60; HT_HG-U133A	SREBF2 ZNF609 ALMS1 FURIN	2.26e-04	196	35	4	1294_DN
Drug	Thiethylperazine malate [52239-63-1]; Down 200; 6uM; MCF7; HT_HG-U133A	CIZ1 PKNOX1 UBAP2L EP300	2.31e-04	197	35	4	6232_DN
Drug	Metanephrine hydrochloride DL [881-95-8]; Up 200; 17.2uM; PC3; HG-U133A	TSC22D1 ZNF609 CDC5L ALMS1	2.31e-04	197	35	4	1933_UP
Drug	Procaine hydrochloride [51-05-8]; Up 200; 14.6uM; PC3; HT_HG-U133A	PKNOX1 ZNF609 EP400 CSNK1G1	2.31e-04	197	35	4	1796_UP
Drug	Idoxuridine [54-42-2]; Down 200; 11.2uM; PC3; HG-U133A	CIZ1 CPSF4 CDC5L ADD3	2.31e-04	197	35	4	1899_DN
Drug	Enilconazole [35554-44-0]; Down 200; 13.4uM; PC3; HT_HG-U133A	PHC3 CDC5L CREB5 FURIN	2.31e-04	197	35	4	5113_DN
Drug	rottlerin; Down 200; 10uM; MCF7; HT_HG-U133A_EA	SREBF2 PKNOX1 ZNF609 ADD3	2.35e-04	198	35	4	914_DN
Drug	Pargyline hydrochloride [306-07-0]; Down 200; 20.4uM; MCF7; HT_HG-U133A	SREBF2 CDC5L ALMS1 EP400	2.35e-04	198	35	4	7016_DN
Drug	2-propylpentanoic acid; Down 200; 1000uM; MCF7; HG-U133A	BPTF CDC5L EP300 FURIN	2.35e-04	198	35	4	23_DN
Drug	BAS 012416453; Down 200; 38uM; MCF7; HT_HG-U133A	SREBF2 PKNOX1 ZNF609 CDC5L	2.35e-04	198	35	4	6908_DN
Drug	(1)-Nipecotic acid [498-95-3]; Down 200; 31uM; PC3; HT_HG-U133A	SREBF2 ALMS1 UBAP2L CSNK1G1	2.35e-04	198	35	4	7296_DN
Drug	Quinic acid [86-68-0]; Up 200; 19.6uM; PC3; HT_HG-U133A	PKNOX1 ZNF609 NR1H4 FURIN	2.35e-04	198	35	4	7317_UP
Drug	Moroxidine hydrochloride [3160-91-6]; Up 200; 19.2uM; MCF7; HT_HG-U133A	SREBF2 PKNOX1 ZNF609 UBAP2L	2.35e-04	198	35	4	5304_UP
Drug	Lisuride (S)(-) [18016-80-3]; Up 200; 11.8uM; PC3; HG-U133A	CIZ1 SREBF2 ZNF609 CDC5L	2.35e-04	198	35	4	1962_UP
Drug	Metampicillin sodium salt [6489-61-8]; Down 200; 10.4uM; PC3; HT_HG-U133A	PHC3 ALMS1 UBAP2L FURIN	2.35e-04	198	35	4	2123_DN
Drug	GBR 12909 dihydrochloride [67469-78-7]; Down 200; 7.6uM; PC3; HT_HG-U133A	PKNOX1 PHC3 ALMS1 NR1H4	2.40e-04	199	35	4	4641_DN
Drug	Methapyrilene hydrochloride [135-23-9]; Down 200; 13.4uM; MCF7; HT_HG-U133A	NFYC TOX4 CDC5L ALMS1	2.40e-04	199	35	4	3205_DN
Drug	2-propylpentanoic acid; Down 200; 50uM; MCF7; HT_HG-U133A	SREBF2 PKNOX1 EP300 ADD3	2.40e-04	199	35	4	6982_DN
Drug	Amphotericin B [1397-89-3]; Down 200; 4.4uM; PC3; HT_HG-U133A	CIZ1 SREBF2 ALMS1 FURIN	2.44e-04	200	35	4	6303_DN
Drug	Denatonium benzoate [3734-33-6]; Down 200; 9uM; MCF7; HT_HG-U133A	PHC3 TOX4 UBAP2L FURIN	2.44e-04	200	35	4	5480_DN
Drug	Minoxidil [38304-91-5]; Down 200; 19.2uM; PC3; HG-U133A	CIZ1 BPTF ALMS1 EP300	2.44e-04	200	35	4	1914_DN
Drug	Epiandrosterone [481-29-8]; Down 200; 13.8uM; PC3; HT_HG-U133A	SREBF2 PKNOX1 PHC3 NR1H4	2.44e-04	200	35	4	4626_DN
Disease	alcohol use disorder (implicated_via_orthology)	CIZ1 SREBF2 CDC5L EP300 ARID2	2.85e-06	195	34	5	DOID:1574 (implicated_via_orthology)
Disease	pulmonary function measurement	NFYC EP400P1 CREB5	9.65e-05	77	34	3	EFO_0003892
Disease	schizophrenia, anorexia nervosa	ALMS1 CREB5	1.41e-03	48	34	2	MONDO_0005090, MONDO_0005351
Disease	cholestasis (biomarker_via_orthology)	CLOCK NR1H4	1.46e-03	49	34	2	DOID:13580 (biomarker_via_orthology)
Disease	IGF-1 measurement	SREBF2 PHC3 CDC5L LIN54	2.31e-03	488	34	4	EFO_0004627
Disease	nephrotic syndrome	CCDC66 PHC1	3.05e-03	71	34	2	EFO_0004255
Disease	non-small cell lung carcinoma	BPTF NR1H4	3.39e-03	75	34	2	EFO_0003060
Disease	osteoarthritis, hip	CDC5L EP300	5.06e-03	92	34	2	EFO_1000786
Disease	neutrophil percentage of leukocytes	CPSF4 CLOCK CREB5 LIN54	5.13e-03	610	34	4	EFO_0007990
Disease	large artery stroke	CDC5L FURIN	7.53e-03	113	34	2	EFO_0005524

Protein segments in the cluster

Peptide	Gene	Start	Entry
PNNSQTQPKQIQLST	TDRD5	866	Q8NAT2
QQQPRSQQSTAASVP	EP300	911	Q09472
TSQPPQQQSPQLTTV	EP400	2851	Q96L91
TPQRQVVQTPNTVLS	CDC5L	396	Q99459
VSQIQSQTQSPQNVP	ADD3	591	Q9UEY8
PSQNSQIVTSRQIQV	ALMS1	3146	Q8TCU4
VSSTVVQQPIQQPQQ	ARID2	906	Q68CP9
QQPQQPTQQSVVIVS	ARID2	916	Q68CP9
TPSQLSPGQQSQVQT	BPTF	2481	Q12830
SPGQQSQVQTTTSQP	BPTF	2486	Q12830
QPQSQPQVQSSTQTL	BPTF	2516	Q12830
NVQFPQVQPQISSSS	NR1H4	61	Q96RI1
AQVSPATQQMQPTQT	CREB5	341	Q02930
NPTSQIVTTSQPQQR	LIN54	421	Q6MZP7
SQQQPLRNQVVSSTN	CSNK1G1	361	Q9HCP0
QPQQTVPRSPQQTRQ	ODAM	156	A1E959
QVTSPLSQQVQTQSP	EP400P1	111	Q6ZTU2
PNQSQSAQQSVVVSP	PHC3	386	Q8NDX5
QQGQQTTSSTTTIQP	NFYC	161	Q13952
QPTQAPTQSNQLINT	NUP54	106	Q7Z3B4
SRQSQSSRESPPQQQ	FURIN	676	P09958
SSPVPVVKNRTQQTQ	CCDC66	796	A2RUB6
LTSQNSSPNQQRTPQ	CPSF4	206	O95639
LSQNQQIPQNSVTPR	AHCTF1	1796	Q8WYP5
TVPTQNVTPNTVNQQ	SEC24B	96	O95487
QQAQTTRPESTQIQP	PIH1D1	36	Q9NWS0
TQTLSPGTIRIQNSQ	PKNOX1	226	P55347
PQISSPQENRNQIST	SHOC1	1111	Q5VXU9
PQSISQSQISQVQLQ	TSC22D1	536	Q15714
QLTSVQQPSQAQLTQ	CLOCK	766	O15516
QVQSQTQPRIPSTDT	CIZ1	321	Q9ULV3
QRSQTSSIPQKPQTN	UBAP2L	1061	Q14157
PQIQASNSQTIQVQP	SP2	136	Q02086
QQSTSPQRVSQVRIP	ZNF256	66	Q9Y2P7
SSQVQPVTIQQQVQT	SREBF2	191	Q12772
LSSSSQQPSVIQQRP	ZNF609	951	O15014
TQQVPPSQSQQQAQT	PHC1	456	P78364
PSQSQQQAQTLVVQP	PHC1	461	P78364
QLGQTSTATIQPSQQ	TOX4	401	O94842