Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR2W3 NPFFR2 CMKLR2 OR2F2 OR8J3 OR10A7 NPY1R ADRA2B HTR4 OR11G2 OR6C2 TAS2R33 TAS2R36 OR6J1 HCAR1 MC2R OR5B21 OR1L6 GPR135 OR14I1 NMUR1 OR4D11 TAS2R30 OR2F1 OR2T11 GRM7 F2RL1 GRM8 OR13J1 OR6X1 CX3CR1 HCRTR1 CXCR2 OR8G2P OR2A2	1.42e-25	884	84	35	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR2W3 NPFFR2 CMKLR2 CHRNA6 OR2F2 OR8J3 OR10A7 NPY1R ADRA2B HTR4 OR11G2 OR6C2 TAS2R33 TAS2R36 OR6J1 HCAR1 MC2R TMEM63B OR5B21 OR1L6 GPR135 OR14I1 NMUR1 HTR3C OR4D11 TAS2R30 OR2F1 OR2T11 GRM7 F2RL1 GRM8 SLC22A17 OR13J1 OR6X1 CX3CR1 HCRTR1 CHRND CXCR2 OR8G2P OR2A2	8.26e-25	1353	84	40	GO:0004888
GeneOntologyMolecularFunction	transporter activity	SLC6A4 CACNA1A CACNA1B CACNA1E SLC22A18 CHRNA6 TMC1 SLCO1C1 SLC24A4 SLC36A4 SLC35D2 ABCA13 SLCO1A2 SLC44A2 TMEM63B SLC28A1 MTTP ABCC11 SLC15A5 SLCO1B3 SLC36A3 SLC35F2 ATP11C HTR3C GRM7 SLC29A1 SLC22A17 CHRND	1.63e-13	1289	84	28	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC6A4 CACNA1A CACNA1B CACNA1E SLC22A18 CHRNA6 TMC1 SLCO1C1 SLC24A4 SLC36A4 SLC35D2 ABCA13 SLCO1A2 SLC44A2 TMEM63B SLC28A1 ABCC11 SLC15A5 SLCO1B3 SLC36A3 SLC35F2 HTR3C GRM7 SLC29A1 SLC22A17 CHRND	1.12e-12	1180	84	26	GO:0022857
GeneOntologyMolecularFunction	olfactory receptor activity	OR2W3 OR2F2 OR8J3 OR10A7 OR11G2 OR6C2 OR6J1 OR5B21 OR1L6 OR14I1 OR4D11 OR2F1 OR2T11 OR13J1 OR6X1 OR8G2P OR2A2	2.38e-12	431	84	17	GO:0004984
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC6A4 SLC22A18 SLCO1C1 SLC24A4 SLC36A4 SLC35D2 SLCO1A2 SLC44A2 SLC28A1 SLC15A5 SLCO1B3 SLC36A3 SLC29A1	3.13e-10	296	84	13	GO:0015291
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC6A4 SLC22A18 SLCO1C1 SLC24A4 SLC36A4 SLC35D2 ABCA13 SLCO1A2 SLC44A2 SLC28A1 ABCC11 SLC15A5 SLCO1B3 SLC36A3 SLC29A1	1.24e-09	477	84	15	GO:0022804
GeneOntologyMolecularFunction	monoatomic cation channel activity	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 TMC1 SLC24A4 TMEM63B HTR3C GRM7 CHRND	1.99e-07	343	84	11	GO:0005261
GeneOntologyMolecularFunction	symporter activity	SLC6A4 SLC22A18 SLC24A4 SLC36A4 SLC28A1 SLC15A5 SLC36A3 SLC29A1	2.26e-07	150	84	8	GO:0015293
GeneOntologyMolecularFunction	organic hydroxy compound transmembrane transporter activity	SLC6A4 SLCO1C1 SLCO1A2 SLC44A2 ABCC11 SLCO1B3	4.89e-07	70	84	6	GO:1901618
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 TMC1 SLC24A4 TMEM63B SLC28A1 SLC36A3 HTR3C GRM7 SLC29A1 CHRND	6.52e-07	664	84	14	GO:0008324
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1A CACNA1B CACNA1E TMC1 GRM7	1.40e-06	46	84	5	GO:0005245
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	NPFFR2 NPY1R MC2R NMUR1 F2RL1 CX3CR1 HCRTR1	1.47e-06	133	84	7	GO:0008528
GeneOntologyMolecularFunction	peptide receptor activity	NPFFR2 NPY1R MC2R NMUR1 F2RL1 CX3CR1 HCRTR1	2.07e-06	140	84	7	GO:0001653
GeneOntologyMolecularFunction	monoatomic ion channel activity	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 TMC1 SLC24A4 TMEM63B HTR3C GRM7 CHRND	3.45e-06	459	84	11	GO:0005216
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 TMC1 SLC24A4 TMEM63B SLC28A1 SLC36A3 HTR3C GRM7 SLC29A1 CHRND	5.20e-06	793	84	14	GO:0015075
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	CACNA1A CACNA1B CACNA1E	5.92e-06	9	84	3	GO:0099511
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	CACNA1A CACNA1B CACNA1E	5.92e-06	9	84	3	GO:0099626
GeneOntologyMolecularFunction	gated channel activity	CACNA1A CACNA1B CACNA1E CHRNA6 TMC1 TMEM63B HTR3C GRM7 CHRND	1.13e-05	334	84	9	GO:0022836
GeneOntologyMolecularFunction	channel activity	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 TMC1 SLC24A4 TMEM63B HTR3C GRM7 CHRND	1.23e-05	525	84	11	GO:0015267
GeneOntologyMolecularFunction	bile acid transmembrane transporter activity	SLCO1C1 SLCO1A2 ABCC11 SLCO1B3	1.23e-05	34	84	4	GO:0015125
GeneOntologyMolecularFunction	passive transmembrane transporter activity	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 TMC1 SLC24A4 TMEM63B HTR3C GRM7 CHRND	1.25e-05	526	84	11	GO:0022803
GeneOntologyMolecularFunction	calcium channel activity	CACNA1A CACNA1B CACNA1E TMC1 SLC24A4 GRM7	1.74e-05	129	84	6	GO:0005262
GeneOntologyMolecularFunction	lipid transporter activity	SLCO1C1 ABCA13 SLCO1A2 MTTP ABCC11 SLCO1B3 ATP11C	1.89e-05	196	84	7	GO:0005319
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1A CACNA1B CACNA1E	2.53e-05	14	84	3	GO:0008331
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC22A18 SLCO1C1 SLC36A4 SLC35D2 SLCO1A2 ABCC11 SLCO1B3 SLC36A3	3.24e-05	293	84	8	GO:0008514
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1A CACNA1B CACNA1E TMC1 SLC24A4 GRM7	4.23e-05	151	84	6	GO:0015085
GeneOntologyMolecularFunction	sodium-independent organic anion transmembrane transporter activity	SLCO1C1 SLCO1A2 SLCO1B3	5.60e-05	18	84	3	GO:0015347
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC6A4 CACNA1A CACNA1B CACNA1E TMC1 SLC24A4 TMEM63B SLC28A1 SLC36A3 GRM7 SLC29A1	6.22e-05	627	84	11	GO:0022890
GeneOntologyMolecularFunction	neuropeptide receptor activity	NPFFR2 NPY1R MC2R NMUR1	7.29e-05	53	84	4	GO:0008188
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC6A4 CACNA1A CACNA1B CACNA1E TMC1 SLC24A4 TMEM63B SLC28A1 ABCC11 SLC36A3 GRM7 SLC29A1	7.55e-05	758	84	12	GO:0015318
GeneOntologyMolecularFunction	nucleoside:sodium symporter activity	SLC28A1 SLC29A1	1.04e-04	4	84	2	GO:0005415
GeneOntologyMolecularFunction	cytidine transmembrane transporter activity	SLC28A1 SLC29A1	1.04e-04	4	84	2	GO:0015212
GeneOntologyMolecularFunction	nucleobase:monoatomic cation symporter activity	SLC28A1 SLC29A1	1.04e-04	4	84	2	GO:0015391
GeneOntologyMolecularFunction	pyrimidine- and adenosine-specific:sodium symporter activity	SLC28A1 SLC29A1	1.04e-04	4	84	2	GO:0015389
GeneOntologyMolecularFunction	group III metabotropic glutamate receptor activity	GRM7 GRM8	1.04e-04	4	84	2	GO:0001642
GeneOntologyMolecularFunction	nucleobase-containing compound transmembrane transporter activity	SLC35D2 SLC28A1 ABCC11 SLC29A1	1.11e-04	59	84	4	GO:0015932
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC6A4 CACNA1A CACNA1B CACNA1E TMC1 SLC24A4 SLC28A1 GRM7 SLC29A1	1.46e-04	465	84	9	GO:0046873
GeneOntologyMolecularFunction	bitter taste receptor activity	TAS2R33 TAS2R36 TAS2R30	1.95e-04	27	84	3	GO:0033038
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	SLCO1C1 SLC36A4 SLCO1A2 ABCC11 SLCO1B3 SLC36A3	2.40e-04	207	84	6	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	SLCO1C1 SLC36A4 SLCO1A2 ABCC11 SLCO1B3 SLC36A3	2.46e-04	208	84	6	GO:0005342
GeneOntologyMolecularFunction	lipid transmembrane transporter activity	SLCO1C1 SLCO1A2 ABCC11 SLCO1B3	2.54e-04	73	84	4	GO:0170055
GeneOntologyMolecularFunction	serotonin receptor activity	HTR4 HTR3C	2.59e-04	6	84	2	GO:0099589
GeneOntologyMolecularFunction	uridine transmembrane transporter activity	SLC28A1 SLC29A1	2.59e-04	6	84	2	GO:0015213
GeneOntologyMolecularFunction	taste receptor activity	TAS2R33 TAS2R36 TAS2R30	3.58e-04	33	84	3	GO:0008527
GeneOntologyMolecularFunction	pyrimidine nucleobase transmembrane transporter activity	SLC28A1 SLC29A1	3.62e-04	7	84	2	GO:0005350
GeneOntologyMolecularFunction	L-proline transmembrane transporter activity	SLC36A4 SLC36A3	3.62e-04	7	84	2	GO:0015193
GeneOntologyMolecularFunction	peptide binding	CACNA1A CACNA1B NPFFR2 CMKLR2 NPY1R NMUR1 HCRTR1	3.86e-04	318	84	7	GO:0042277
GeneOntologyMolecularFunction	organic cation transmembrane transporter activity	SLC36A4 SLCO1A2 SLC44A2 SLC36A3	4.16e-04	83	84	4	GO:0015101
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNA1A CACNA1B CACNA1E TMC1 GRM7	4.55e-04	152	84	5	GO:0022843
GeneOntologyMolecularFunction	pyrimidine nucleoside transmembrane transporter activity	SLC28A1 SLC29A1	4.82e-04	8	84	2	GO:0015214
GeneOntologyMolecularFunction	neuropeptide binding	CMKLR2 NPY1R NMUR1	5.03e-04	37	84	3	GO:0042923
GeneOntologyMolecularFunction	monocarboxylic acid transmembrane transporter activity	SLCO1C1 SLCO1A2 ABCC11 SLCO1B3	5.66e-04	90	84	4	GO:0008028
GeneOntologyMolecularFunction	G protein-coupled glutamate receptor activity	GRM7 GRM8	6.18e-04	9	84	2	GO:0098988
GeneOntologyMolecularFunction	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	GRM7 GRM8	6.18e-04	9	84	2	GO:0001640
GeneOntologyMolecularFunction	thyroid hormone transmembrane transporter activity	SLCO1C1 SLCO1A2	6.18e-04	9	84	2	GO:0015349
GeneOntologyMolecularFunction	L-alanine transmembrane transporter activity	SLC36A4 SLC36A3	6.18e-04	9	84	2	GO:0015180
GeneOntologyMolecularFunction	purine nucleobase transmembrane transporter activity	SLC28A1 SLC29A1	7.70e-04	10	84	2	GO:0005345
GeneOntologyMolecularFunction	nucleoside transmembrane transporter activity	SLC28A1 SLC29A1	7.70e-04	10	84	2	GO:0005337
GeneOntologyMolecularFunction	excitatory extracellular ligand-gated monoatomic ion channel activity	CHRNA6 HTR3C CHRND	7.85e-04	43	84	3	GO:0005231
GeneOntologyMolecularFunction	neurotransmitter receptor activity	CHRNA6 HTR4 HTR3C CHRND	8.41e-04	100	84	4	GO:0030594
GeneOntologyMolecularFunction	nucleobase transmembrane transporter activity	SLC28A1 SLC29A1	9.38e-04	11	84	2	GO:0015205
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNA1A CACNA1B CACNA1E TMC1 GRM7	1.03e-03	182	84	5	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNA1A CACNA1B CACNA1E TMC1 GRM7	1.08e-03	184	84	5	GO:0022832
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC6A4 SLC28A1 SLC36A3 SLC29A1	1.60e-03	119	84	4	GO:0015294
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	CHRNA6 HTR3C CHRND	1.78e-03	57	84	3	GO:1904315
GeneOntologyMolecularFunction	carbohydrate derivative transmembrane transporter activity	SLC35D2 SLC28A1 SLC29A1	1.97e-03	59	84	3	GO:1901505
GeneOntologyMolecularFunction	alanine transmembrane transporter activity	SLC36A4 SLC36A3	2.02e-03	16	84	2	GO:0022858
GeneOntologyMolecularFunction	odorant binding	OR8J3 OR5B21 OR14I1 OR8G2P	2.03e-03	127	84	4	GO:0005549
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	CHRNA6 HTR3C CHRND	2.07e-03	60	84	3	GO:0099529
GeneOntologyMolecularFunction	acetylcholine-gated monoatomic cation-selective channel activity	CHRNA6 CHRND	2.28e-03	17	84	2	GO:0022848
GeneOntologyMolecularFunction	mechanosensitive monoatomic ion channel activity	TMC1 TMEM63B	2.56e-03	18	84	2	GO:0008381
GeneOntologyMolecularFunction	transmitter-gated channel activity	CHRNA6 HTR3C CHRND	2.60e-03	65	84	3	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	CHRNA6 HTR3C CHRND	2.60e-03	65	84	3	GO:0022824
GeneOntologyMolecularFunction	antiporter activity	SLC6A4 SLC24A4 SLC35D2 SLC44A2	2.75e-03	138	84	4	GO:0015297
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	CHRNA6 TMEM63B HTR3C CHRND	2.89e-03	140	84	4	GO:0099094
GeneOntologyMolecularFunction	neurotransmitter transmembrane transporter activity	SLC6A4 SLC29A1	3.49e-03	21	84	2	GO:0005326
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	CHRNA6 HTR3C CHRND	3.90e-03	75	84	3	GO:0098960
GeneOntologyMolecularFunction	acetylcholine receptor activity	CHRNA6 CHRND	4.18e-03	23	84	2	GO:0015464
GeneOntologyMolecularFunction	C-C chemokine receptor activity	CX3CR1 CXCR2	4.18e-03	23	84	2	GO:0016493
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	CHRNA6 HTR3C CHRND	4.20e-03	77	84	3	GO:0005230
GeneOntologyMolecularFunction	C-C chemokine binding	CX3CR1 CXCR2	4.54e-03	24	84	2	GO:0019957
GeneOntologyMolecularFunction	solute:sodium symporter activity	SLC6A4 SLC28A1 SLC29A1	4.84e-03	81	84	3	GO:0015370
GeneOntologyMolecularFunction	G protein-coupled chemoattractant receptor activity	CX3CR1 CXCR2	5.32e-03	26	84	2	GO:0001637
GeneOntologyMolecularFunction	chemokine receptor activity	CX3CR1 CXCR2	5.32e-03	26	84	2	GO:0004950
GeneOntologyMolecularFunction	glutamate receptor activity	GRM7 GRM8	5.73e-03	27	84	2	GO:0008066
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC6A4 SLC24A4 SLC28A1 SLC29A1	5.89e-03	171	84	4	GO:0015081
GeneOntologyMolecularFunction	calcium-dependent protein binding	SLC24A4 WFS1 GRM7	8.20e-03	98	84	3	GO:0048306
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR2W3 NPFFR2 CMKLR2 OR2F2 OR8J3 OR10A7 NPY1R ADRA2B HTR4 SLC24A4 OR11G2 OR6C2 TAS2R33 TAS2R36 OR6J1 HCAR1 MC2R OR5B21 OR1L6 GPR135 OR14I1 NMUR1 OR4D11 TAS2R30 OR2F1 OR2T11 GRM7 F2RL1 GRM8 NMS OR13J1 OR6X1 CX3CR1 HCRTR1 CXCR2 OR8G2P OR2A2	8.16e-22	1395	83	37	GO:0007186
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR2W3 OR2F2 OR8J3 OR10A7 TMC1 SLC24A4 OR11G2 OR6C2 TAS2R33 TAS2R36 OR6J1 OR5B21 OR1L6 OR14I1 OR4D11 TAS2R30 PPEF1 OR2F1 OR2T11 GRM8 OR13J1 OR6X1 OR8G2P OR2A2	3.94e-18	582	83	24	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	OR2W3 NPFFR2 OR2F2 OR8J3 OR10A7 TMC1 SLC24A4 OR11G2 OR6C2 TAS2R33 TAS2R36 OR6J1 OR5B21 OR1L6 OR14I1 OR4D11 TAS2R30 PPEF1 OR2F1 OR2T11 GRM8 OR13J1 OR6X1 OR8G2P OR2A2	4.25e-17	722	83	25	GO:0051606
GeneOntologyBiologicalProcess	sensory perception	OR2W3 CACNA1E OR2F2 OR8J3 OR10A7 NPY1R TMC1 SLC24A4 OR11G2 WFS1 OR6C2 TAS2R33 TAS2R36 OR6J1 TMEM63B OR5B21 OR1L6 OR14I1 OR4D11 TAS2R30 PPEF1 OR2F1 OR2T11 GRM7 GRM8 OR13J1 OR6X1 OR8G2P OR2A2	5.13e-17	1072	83	29	GO:0007600
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR2W3 OR2F2 OR8J3 OR10A7 SLC24A4 OR11G2 OR6C2 TAS2R33 TAS2R36 OR6J1 OR5B21 OR1L6 OR14I1 OR4D11 TAS2R30 OR2F1 OR2T11 OR13J1 OR6X1 OR8G2P OR2A2	2.61e-16	485	83	21	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR2W3 OR2F2 OR8J3 OR10A7 SLC24A4 OR11G2 OR6C2 TAS2R33 TAS2R36 OR6J1 OR5B21 OR1L6 OR14I1 OR4D11 TAS2R30 OR2F1 OR2T11 OR13J1 OR6X1 OR8G2P OR2A2	1.22e-15	524	83	21	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR2W3 OR2F2 OR8J3 OR10A7 SLC24A4 OR11G2 OR6C2 TAS2R33 TAS2R36 OR6J1 OR5B21 OR1L6 OR14I1 OR4D11 TAS2R30 OR2F1 OR2T11 OR13J1 OR6X1 OR8G2P OR2A2	2.86e-15	547	83	21	GO:0007606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR2W3 OR2F2 OR8J3 OR10A7 SLC24A4 OR11G2 OR6C2 OR6J1 OR5B21 OR1L6 OR14I1 OR4D11 OR2F1 OR2T11 OR13J1 OR6X1 OR8G2P OR2A2	9.07e-14	432	83	18	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR2W3 OR2F2 OR8J3 OR10A7 SLC24A4 OR11G2 OR6C2 OR6J1 OR5B21 OR1L6 OR14I1 OR4D11 OR2F1 OR2T11 OR13J1 OR6X1 OR8G2P OR2A2	3.17e-13	465	83	18	GO:0007608
GeneOntologyBiologicalProcess	monoatomic ion transport	SLC6A4 CACNA1A CACNA1B CACNA1E SLC22A18 CHRNA6 TMC1 SLCO1C1 SLC24A4 WFS1 SLCO1A2 TMEM63B ABCC11 SLCO1B3 NMUR1 SLC36A3 ATP11C HTR3C SLC22A17 CHRND	3.69e-07	1374	83	20	GO:0006811
GeneOntologyBiologicalProcess	neuropeptide signaling pathway	NPFFR2 CMKLR2 NPY1R MC2R NMUR1 NMS HCRTR1	6.80e-07	124	83	7	GO:0007218
GeneOntologyBiologicalProcess	organic hydroxy compound transport	SLC6A4 CHRNA6 ADRA2B SLCO1C1 ABCA13 SLCO1A2 SLC44A2 MTTP ABCC11 SLCO1B3	1.73e-06	358	83	10	GO:0015850
GeneOntologyBiologicalProcess	organic cation transport	CACNA1A SLC22A18 ADRA2B SLC36A4 SLCO1A2 SLC44A2 SLC36A3	1.95e-06	145	83	7	GO:0015695
GeneOntologyBiologicalProcess	anterograde trans-synaptic signaling	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 NPY1R HTR4 HTR3C COLQ GRM7 GRM8 SLC29A1 CX3CR1 HCRTR1 CHRND	4.03e-06	931	83	15	GO:0098916
GeneOntologyBiologicalProcess	chemical synaptic transmission	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 NPY1R HTR4 HTR3C COLQ GRM7 GRM8 SLC29A1 CX3CR1 HCRTR1 CHRND	4.03e-06	931	83	15	GO:0007268
GeneOntologyBiologicalProcess	trans-synaptic signaling	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 NPY1R HTR4 HTR3C COLQ GRM7 GRM8 SLC29A1 CX3CR1 HCRTR1 CHRND	4.47e-06	939	83	15	GO:0099537
GeneOntologyBiologicalProcess	synaptic signaling	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 NPY1R HTR4 HTR3C COLQ GRM7 GRM8 SLC29A1 CX3CR1 HCRTR1 CHRND	7.13e-06	976	83	15	GO:0099536
GeneOntologyBiologicalProcess	sodium-independent organic anion transport	SLCO1C1 SLCO1A2 SLCO1B3	2.76e-05	15	83	3	GO:0043252
GeneOntologyBiologicalProcess	synaptic transmission, cholinergic	CACNA1A CHRNA6 COLQ CHRND	2.93e-05	44	83	4	GO:0007271
GeneOntologyBiologicalProcess	bile acid and bile salt transport	SLCO1C1 SLCO1A2 ABCC11 SLCO1B3	3.81e-05	47	83	4	GO:0015721
GeneOntologyBiologicalProcess	carboxylic acid transport	CACNA1A SLCO1C1 SLC36A4 SLC35D2 SLCO1A2 ABCC11 SLCO1B3 SLC36A3 GRM7	3.98e-05	410	83	9	GO:0046942
GeneOntologyBiologicalProcess	organic anion transport	CACNA1A SLCO1C1 SLC36A4 SLC35D2 SLCO1A2 MTTP ABCC11 SLCO1B3 SLC36A3 GRM7	4.10e-05	515	83	10	GO:0015711
GeneOntologyBiologicalProcess	organic acid transport	CACNA1A SLCO1C1 SLC36A4 SLC35D2 SLCO1A2 ABCC11 SLCO1B3 SLC36A3 GRM7	4.13e-05	412	83	9	GO:0015849
GeneOntologyBiologicalProcess	calcium ion import across plasma membrane	CACNA1A CACNA1B CACNA1E SLC24A4	4.14e-05	48	83	4	GO:0098703
GeneOntologyBiologicalProcess	calcium ion import into cytosol	CACNA1A CACNA1B CACNA1E SLC24A4	4.14e-05	48	83	4	GO:1902656
GeneOntologyBiologicalProcess	neurotransmitter transport	SLC6A4 CACNA1A CACNA1B CACNA1E NPY1R GRM8 SLC29A1	8.36e-05	259	83	7	GO:0006836
GeneOntologyBiologicalProcess	cytidine transport	SLC28A1 SLC29A1	9.55e-05	4	83	2	GO:0015861
GeneOntologyBiologicalProcess	regulation of neurotransmitter secretion	CACNA1A CACNA1B CACNA1E NPY1R GRM8	1.14e-04	118	83	5	GO:0046928
GeneOntologyBiologicalProcess	amine transport	CACNA1A CHRNA6 ADRA2B SLC44A2 GRM7	2.30e-04	137	83	5	GO:0015837
GeneOntologyBiologicalProcess	pyrimidine nucleoside transport	SLC28A1 SLC29A1	2.37e-04	6	83	2	GO:0015864
GeneOntologyBiologicalProcess	uridine transmembrane transport	SLC28A1 SLC29A1	2.37e-04	6	83	2	GO:0015862
GeneOntologyBiologicalProcess	regulation of neurotransmitter transport	CACNA1A CACNA1B CACNA1E NPY1R GRM8	2.63e-04	141	83	5	GO:0051588
GeneOntologyBiologicalProcess	pyrimidine nucleobase transport	SLC28A1 SLC29A1	3.32e-04	7	83	2	GO:0015855
GeneOntologyBiologicalProcess	import across plasma membrane	CACNA1A CACNA1B CACNA1E SLC24A4 SLC36A4 SLC28A1	3.32e-04	230	83	6	GO:0098739
GeneOntologyBiologicalProcess	secretion	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 NPY1R ADRA2B HTR4 TMEM63B MTTP GRM7 F2RL1 GRM8 SLC29A1	3.43e-04	1221	83	14	GO:0046903
GeneOntologyBiologicalProcess	regulation of cytosolic calcium ion concentration	CACNA1A NPY1R TMEM64 HCRTR1	3.68e-04	84	83	4	GO:0051480
GeneOntologyBiologicalProcess	nucleoside transmembrane transport	SLC28A1 SLC29A1	4.41e-04	8	83	2	GO:1901642
GeneOntologyBiologicalProcess	purine nucleobase transmembrane transport	SLC28A1 SLC29A1	4.41e-04	8	83	2	GO:1904823
GeneOntologyBiologicalProcess	vascular process in circulatory system	SLC6A4 NPY1R ADRA2B SLCO1C1 F2RL1 SLC29A1 CXCR2	4.73e-04	344	83	7	GO:0003018
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 TMC1 SLC24A4 TMEM63B ABCC11 SLC36A3 ATP11C HTR3C CHRND	4.88e-04	1115	83	13	GO:0034220
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	GRM7 GRM8	5.65e-04	9	83	2	GO:0007196
GeneOntologyBiologicalProcess	central nervous system maturation	CACNA1A CX3CR1	5.65e-04	9	83	2	GO:0021626
GeneOntologyBiologicalProcess	calcium ion import	CACNA1A CACNA1B CACNA1E SLC24A4	6.61e-04	98	83	4	GO:0070509
GeneOntologyBiologicalProcess	export from cell	SLC6A4 CACNA1A CACNA1B CACNA1E SLC22A18 CHRNA6 NPY1R ADRA2B SLC24A4 MTTP GRM7 F2RL1 GRM8	6.68e-04	1153	83	13	GO:0140352
GeneOntologyBiologicalProcess	nucleoside transport	SLC28A1 SLC29A1	7.05e-04	10	83	2	GO:0015858
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of bitter taste	TAS2R33 TAS2R36 TAS2R30	7.39e-04	44	83	3	GO:0001580
GeneOntologyBiologicalProcess	regulation of secretion by cell	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 NPY1R ADRA2B GRM7 F2RL1 GRM8	7.61e-04	740	83	10	GO:1903530
GeneOntologyBiologicalProcess	proline transmembrane transport	SLC36A4 SLC36A3	8.59e-04	11	83	2	GO:0035524
GeneOntologyBiologicalProcess	L-alanine transport	SLC36A4 SLC36A3	8.59e-04	11	83	2	GO:0015808
GeneOntologyBiologicalProcess	behavior	SLC6A4 CACNA1A CACNA1B CACNA1E NPY1R SLC24A4 WFS1 GRM7 NMS CX3CR1 HCRTR1	8.65e-04	891	83	11	GO:0007610
GeneOntologyBiologicalProcess	sensory perception of bitter taste	TAS2R33 TAS2R36 TAS2R30	9.54e-04	48	83	3	GO:0050913
GeneOntologyBiologicalProcess	purine nucleobase transport	SLC28A1 SLC29A1	1.03e-03	12	83	2	GO:0006863
GeneOntologyBiologicalProcess	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	NPY1R ADRA2B HTR4 MC2R GRM7 GRM8	1.04e-03	286	83	6	GO:0007188
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of taste	TAS2R33 TAS2R36 TAS2R30	1.07e-03	50	83	3	GO:0050912
GeneOntologyBiologicalProcess	response to pain	CACNA1A CACNA1B CACNA1E	1.14e-03	51	83	3	GO:0048265
GeneOntologyBiologicalProcess	signal release from synapse	CACNA1A CACNA1B CACNA1E NPY1R GRM8	1.15e-03	195	83	5	GO:0099643
GeneOntologyBiologicalProcess	amino acid transport	SLC6A4 CACNA1A SLC36A4 SLC36A3 GRM7	1.15e-03	195	83	5	GO:0006865
GeneOntologyBiologicalProcess	neurotransmitter secretion	CACNA1A CACNA1B CACNA1E NPY1R GRM8	1.15e-03	195	83	5	GO:0007269
GeneOntologyBiologicalProcess	nucleobase transport	SLC28A1 SLC29A1	1.21e-03	13	83	2	GO:0015851
GeneOntologyBiologicalProcess	signal release	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 NPY1R ADRA2B F2RL1 GRM8	1.23e-03	653	83	9	GO:0023061
GeneOntologyBiologicalProcess	modulation of chemical synaptic transmission	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 NPY1R GRM7 GRM8 CX3CR1	1.37e-03	663	83	9	GO:0050804
GeneOntologyBiologicalProcess	regulation of trans-synaptic signaling	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 NPY1R GRM7 GRM8 CX3CR1	1.38e-03	664	83	9	GO:0099177
GeneOntologyBiologicalProcess	regulation of secretion	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 NPY1R ADRA2B GRM7 F2RL1 GRM8	1.38e-03	801	83	10	GO:0051046
GeneOntologyBiologicalProcess	chemical homeostasis	CACNA1A CMKLR2 CACNA1E NPY1R SLC24A4 WFS1 SLCO1A2 TMEM63B MTTP SLC29A1 SLC22A17 TMEM64 HCRTR1	1.39e-03	1249	83	13	GO:0048878
GeneOntologyBiologicalProcess	membrane depolarization	SLC6A4 CACNA1A CHRNA6 CHRND	1.45e-03	121	83	4	GO:0051899
GeneOntologyBiologicalProcess	synaptic vesicle exocytosis	CACNA1A CACNA1B CACNA1E NPY1R	1.63e-03	125	83	4	GO:0016079
GeneOntologyBiologicalProcess	regulation of amine transport	CACNA1A CHRNA6 ADRA2B GRM7	1.63e-03	125	83	4	GO:0051952
GeneOntologyBiologicalProcess	multicellular organismal response to stress	CACNA1A CACNA1B CACNA1E GRM7	1.68e-03	126	83	4	GO:0033555
GeneOntologyBiologicalProcess	pyrimidine-containing compound transmembrane transport	SLC28A1 SLC29A1	1.85e-03	16	83	2	GO:0072531
GeneOntologyBiologicalProcess	G protein-coupled glutamate receptor signaling pathway	GRM7 GRM8	1.85e-03	16	83	2	GO:0007216
GeneOntologyBiologicalProcess	excitatory postsynaptic potential	CHRNA6 HTR3C SLC29A1 CHRND	1.88e-03	130	83	4	GO:0060079
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	NPY1R HTR4 MC2R	1.91e-03	61	83	3	GO:0007187
GeneOntologyBiologicalProcess	phospholipase C-activating G protein-coupled receptor signaling pathway	NMUR1 F2RL1 CX3CR1 CXCR2	2.05e-03	133	83	4	GO:0007200
GeneOntologyCellularComponent	presynaptic membrane	SLC6A4 CACNA1A CACNA1E CHRNA6 NPY1R GRM7 GRM8	1.26e-04	277	84	7	GO:0042734
GeneOntologyCellularComponent	vacuolar membrane	SLC36A4 ABCA13 SLC44A2 GPR137B ABCC11 SLC36A3 ATP11C SPPL2B SLC22A17	1.98e-04	507	84	9	GO:0005774
GeneOntologyCellularComponent	synaptic membrane	SLC6A4 CACNA1A CACNA1E CHRNA6 NPY1R HTR3C GRM7 GRM8 CHRND	5.50e-04	583	84	9	GO:0097060
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1A CACNA1B CACNA1E	8.39e-04	46	84	3	GO:0005891
GeneOntologyCellularComponent	postsynaptic membrane	SLC6A4 CACNA1A CACNA1E CHRNA6 HTR3C GRM7 CHRND	1.22e-03	405	84	7	GO:0045211
MousePheno	abnormal behavioral response to xenobiotic	SLC6A4 CACNA1A CACNA1B NPY1R HTR4 WFS1 MC2R GRM7 SLC29A1 HCRTR1	2.92e-07	309	55	10	MP:0009745
MousePheno	impaired behavioral response to alcohol	CACNA1B NPY1R SLC29A1	6.78e-06	10	55	3	MP:0009755
MousePheno	impaired behavioral response to xenobiotic	SLC6A4 CACNA1B NPY1R WFS1 SLC29A1	1.80e-05	83	55	5	MP:0009747
MousePheno	impaired behavioral response to addictive substance	CACNA1B NPY1R WFS1 SLC29A1	2.83e-05	45	55	4	MP:0009750
MousePheno	abnormal physiological response to xenobiotic	FANCD2 SLC6A4 CACNA1A CACNA1E NPY1R HTR4 SLCO1B3 GRM7 F2RL1 GRM8 CX3CR1	4.40e-05	662	55	11	MP:0008872
MousePheno	abnormal hormone level	SLC6A4 CACNA1A CACNA1B NPFFR2 CMKLR2 CACNA1E NPY1R SLCO1C1 WFS1 MC2R MBOAT4 TMEM64 LCLAT1 CXCR2	4.99e-05	1073	55	14	MP:0003953
MousePheno	increased susceptibility to pharmacologically induced seizures	CACNA1A HTR4 MC2R GRM7 HCRTR1	9.39e-05	117	55	5	MP:0002906
MousePheno	increased susceptibility to induction of seizure by inducing agent	CACNA1A HTR4 MC2R GRM7 HCRTR1	9.78e-05	118	55	5	MP:0012349
MousePheno	abnormal behavioral response to alcohol	CACNA1B NPY1R SLC29A1	1.10e-04	24	55	3	MP:0020157
MousePheno	abnormal seizure response to pharmacological agent	CACNA1A HTR4 MC2R GRM7 HCRTR1	2.74e-04	147	55	5	MP:0000950
MousePheno	abnormal channel response	CACNA1A CACNA1B CACNA1E	2.89e-04	33	55	3	MP:0003484
MousePheno	abnormal alcohol consumption	CACNA1B NPY1R SLC29A1	3.45e-04	35	55	3	MP:0001425
Domain	7tm_1	OR2W3 NPFFR2 CMKLR2 OR2F2 OR8J3 OR10A7 NPY1R ADRA2B HTR4 OR11G2 OR6C2 OR6J1 HCAR1 MC2R OR5B21 OR1L6 GPR135 OR14I1 NMUR1 OR4D11 OR2F1 OR2T11 F2RL1 OR13J1 OR6X1 CX3CR1 HCRTR1 CXCR2 OR8G2P OR2A2	1.82e-22	677	83	30	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2W3 NPFFR2 CMKLR2 OR2F2 OR8J3 OR10A7 NPY1R ADRA2B HTR4 OR11G2 OR6C2 OR6J1 HCAR1 MC2R OR5B21 OR1L6 GPR135 OR14I1 NMUR1 OR4D11 OR2F1 OR2T11 F2RL1 OR13J1 OR6X1 CX3CR1 HCRTR1 CXCR2 OR8G2P OR2A2	2.55e-22	685	83	30	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2W3 NPFFR2 CMKLR2 OR2F2 OR8J3 OR10A7 NPY1R ADRA2B HTR4 OR11G2 OR6C2 OR6J1 HCAR1 MC2R OR5B21 OR1L6 GPR135 OR14I1 NMUR1 OR4D11 OR2F1 OR2T11 F2RL1 OR13J1 OR6X1 CX3CR1 HCRTR1 CXCR2 OR8G2P OR2A2	3.28e-22	691	83	30	PS50262
Domain	GPCR_Rhodpsn	OR2W3 NPFFR2 CMKLR2 OR2F2 OR8J3 OR10A7 NPY1R ADRA2B HTR4 OR11G2 OR6C2 OR6J1 HCAR1 MC2R OR5B21 OR1L6 GPR135 OR14I1 NMUR1 OR4D11 OR2F1 OR2T11 F2RL1 OR13J1 OR6X1 CX3CR1 HCRTR1 CXCR2 OR8G2P OR2A2	3.42e-22	692	83	30	IPR000276
Domain	GPCR_Rhodpsn_7TM	OR2W3 NPFFR2 CMKLR2 OR2F2 OR8J3 OR10A7 NPY1R ADRA2B HTR4 OR11G2 OR6C2 HCAR1 MC2R OR5B21 OR1L6 GPR135 OR14I1 NMUR1 OR4D11 OR2F1 OR2T11 F2RL1 OR13J1 OR6X1 CX3CR1 HCRTR1 CXCR2 OR8G2P OR2A2	2.11e-21	670	83	29	IPR017452
Domain	Olfact_rcpt	OR2W3 OR2F2 OR8J3 OR10A7 OR11G2 OR6C2 OR6J1 OR5B21 OR1L6 OR14I1 OR4D11 OR2F1 OR2T11 OR13J1 OR6X1 OR8G2P OR2A2	1.26e-12	393	83	17	IPR000725
Domain	MFS_dom	SLC22A18 SLCO1C1 SLCO1A2 SLC15A5 SLCO1B3 SLC29A1 SLC22A17	2.21e-06	134	83	7	IPR020846
Domain	GPHH_dom	CACNA1A CACNA1B CACNA1E	2.92e-06	7	83	3	IPR031649
Domain	VDCC_a1su_IQ	CACNA1A CACNA1B CACNA1E	2.92e-06	7	83	3	IPR014873
Domain	Ca_chan_IQ	CACNA1A CACNA1B CACNA1E	2.92e-06	7	83	3	SM01062
Domain	Ca_chan_IQ	CACNA1A CACNA1B CACNA1E	2.92e-06	7	83	3	PF08763
Domain	GPHH	CACNA1A CACNA1B CACNA1E	2.92e-06	7	83	3	PF16905
Domain	VDCCAlpha1	CACNA1A CACNA1B CACNA1E	9.93e-06	10	83	3	IPR002077
Domain	7TM_GPCR_Srsx	NPFFR2 ADRA2B HTR4 MC2R NMUR1 HCRTR1	1.05e-05	112	83	6	SM01381
Domain	OA_transporter	SLCO1C1 SLCO1A2 SLCO1B3	1.81e-05	12	83	3	IPR004156
Domain	OATP	SLCO1C1 SLCO1A2 SLCO1B3	1.81e-05	12	83	3	PF03137
Domain	MFS	SLC22A18 SLCO1C1 SLCO1A2 SLCO1B3 SLC22A17	1.20e-04	108	83	5	PS50850
Domain	Acetylcholine_rcpt_TM	CHRNA6 HTR3C CHRND	1.41e-04	23	83	3	IPR027361
Domain	-	CHRNA6 HTR3C CHRND	1.41e-04	23	83	3	1.20.120.370
Domain	CXCR4/ACKR2	CX3CR1 CXCR2	4.04e-04	7	83	2	IPR001277
Domain	GPCR_3_mtglu_rcpt	GRM7 GRM8	5.37e-04	8	83	2	IPR000162
Domain	Kazal_2	SLCO1C1 SLCO1A2 SLCO1B3	5.44e-04	36	83	3	PF07648
Domain	ADR_fam	ADRA2B HTR4	8.58e-04	10	83	2	IPR002233
Domain	Neurotransmitter_ion_chnl_CS	CHRNA6 HTR3C CHRND	1.05e-03	45	83	3	IPR018000
Domain	Neur_chan_memb	CHRNA6 HTR3C CHRND	1.12e-03	46	83	3	PF02932
Domain	KAZAL	SLCO1C1 SLCO1A2 SLCO1B3	1.12e-03	46	83	3	SM00280
Domain	Neur_chan_LBD	CHRNA6 HTR3C CHRND	1.19e-03	47	83	3	PF02931
Domain	Neur_channel	CHRNA6 HTR3C CHRND	1.19e-03	47	83	3	IPR006201
Domain	Neur_chan_lig-bd	CHRNA6 HTR3C CHRND	1.19e-03	47	83	3	IPR006202
Domain	NEUROTR_ION_CHANNEL	CHRNA6 HTR3C CHRND	1.19e-03	47	83	3	PS00236
Domain	Neurotrans-gated_channel_TM	CHRNA6 HTR3C CHRND	1.19e-03	47	83	3	IPR006029
Domain	-	CHRNA6 HTR3C CHRND	1.19e-03	47	83	3	2.70.170.10
Domain	KAZAL_2	SLCO1C1 SLCO1A2 SLCO1B3	1.43e-03	50	83	3	PS51465
Domain	NCD3G	GRM7 GRM8	1.47e-03	13	83	2	PF07562
Domain	GPCR_3_9-Cys_dom	GRM7 GRM8	1.47e-03	13	83	2	IPR011500
Domain	Kazal_dom	SLCO1C1 SLCO1A2 SLCO1B3	1.51e-03	51	83	3	IPR002350
Domain	GPCR_3_CS	GRM7 GRM8	1.72e-03	14	83	2	IPR017979
Domain	Channel_four-helix_dom	CACNA1A CACNA1B CACNA1E	2.08e-03	57	83	3	IPR027359
Domain	-	CACNA1A CACNA1B CACNA1E	2.08e-03	57	83	3	1.20.120.350
Domain	Nicotinic_acetylcholine_rcpt	CHRNA6 CHRND	2.25e-03	16	83	2	IPR002394
Domain	Aa_trans	SLC36A4 SLC36A3	2.54e-03	17	83	2	PF01490
Domain	AA_transpt_TM	SLC36A4 SLC36A3	2.54e-03	17	83	2	IPR013057
Domain	GPCR_3	GRM7 GRM8	3.88e-03	21	83	2	IPR000337
Domain	G_PROTEIN_RECEP_F3_4	GRM7 GRM8	4.25e-03	22	83	2	PS50259
Domain	7tm_3	GRM7 GRM8	4.25e-03	22	83	2	PF00003
Domain	GPCR_3_C	GRM7 GRM8	4.25e-03	22	83	2	IPR017978
Domain	G_PROTEIN_RECEP_F3_2	GRM7 GRM8	4.25e-03	22	83	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GRM7 GRM8	4.25e-03	22	83	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GRM7 GRM8	4.25e-03	22	83	2	PS00979
Domain	FYVE	FGD2 FGD4	7.33e-03	29	83	2	PF01363
Domain	FYVE	FGD2 FGD4	7.33e-03	29	83	2	SM00064
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	NPFFR2 CMKLR2 OR2F2 NPY1R ADRA2B HTR4 HCAR1 MC2R NMUR1 OR2F1 F2RL1 CX3CR1 HCRTR1 CXCR2	4.28e-11	260	72	14	M39397
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR2W3 OR2F2 OR8J3 OR10A7 OR11G2 OR6C2 OR5B21 OR1L6 OR14I1 OR4D11 OR2F1 OR2T11 OR13J1 OR6X1 OR8G2P OR2A2	8.36e-11	389	72	16	M14091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2W3 OR2F2 OR8J3 OR10A7 OR11G2 OR6C2 OR6J1 OR5B21 OR1L6 OR14I1 OR4D11 OR2F1 OR2T11 OR13J1 OR6X1 OR2A2	2.33e-10	417	72	16	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR2W3 OR2F2 OR8J3 OR10A7 TMC1 OR11G2 OR6C2 OR6J1 OR5B21 OR1L6 OR14I1 OR4D11 TAS2R30 PPEF1 OR2F1 OR2T11 OR13J1 OR6X1 OR2A2	2.59e-10	636	72	19	M41834
Pathway	REACTOME_GPCR_LIGAND_BINDING	NPFFR2 NPY1R ADRA2B HTR4 HCAR1 MC2R NMUR1 TAS2R30 GRM7 F2RL1 PLPPR1 GRM8 NMS CX3CR1 HCRTR1 CXCR2	3.66e-10	430	72	16	MM15160
Pathway	REACTOME_GPCR_LIGAND_BINDING	NPFFR2 NPY1R ADRA2B HTR4 HCAR1 MC2R NMUR1 TAS2R30 GRM7 F2RL1 PLPPR1 GRM8 NMS CX3CR1 HCRTR1 CXCR2	1.07e-09	463	72	16	M507
Pathway	REACTOME_SIGNALING_BY_GPCR	NPFFR2 NPY1R ADRA2B HTR4 FGD2 FGD4 HCAR1 MC2R NMUR1 TAS2R30 GRM7 F2RL1 PLPPR1 GRM8 NMS CX3CR1 HCRTR1 CXCR2	2.55e-09	646	72	18	MM14962
Pathway	WP_GPCRS_NONODORANT	NPFFR2 NPY1R ADRA2B HTR4 MC2R NMUR1 GRM7 F2RL1 GRM8 CX3CR1 HCRTR1 CXCR2	8.94e-09	266	72	12	MM15843
Pathway	REACTOME_SIGNALING_BY_GPCR	NPFFR2 NPY1R ADRA2B HTR4 FGD2 FGD4 HCAR1 MC2R NMUR1 TAS2R30 GRM7 F2RL1 PLPPR1 GRM8 NMS CX3CR1 HCRTR1 CXCR2	9.41e-09	702	72	18	M746
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	NPFFR2 NPY1R ADRA2B HTR4 HCAR1 MC2R NMUR1 F2RL1 PLPPR1 NMS CX3CR1 HCRTR1 CXCR2	1.03e-08	330	72	13	M18334
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	NPFFR2 NPY1R ADRA2B HTR4 HCAR1 MC2R NMUR1 F2RL1 PLPPR1 NMS CX3CR1 HCRTR1 CXCR2	1.14e-08	333	72	13	MM14963
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	NPFFR2 CHRNA6 NPY1R ADRA2B HTR4 MC2R NMUR1 GRM7 F2RL1 GRM8 HCRTR1 CHRND	1.15e-08	272	72	12	M13380
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	NPY1R ADRA2B HTR4 MC2R NMUR1 F2RL1 OR13J1 CX3CR1 CXCR2 OR8G2P	3.31e-08	186	72	10	MM15994
Pathway	REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES	SLCO1C1 SLC35D2 SLCO1A2 SLC28A1 SLCO1B3 SLC29A1	5.60e-08	41	72	6	MM15075
Pathway	REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES	SLCO1C1 SLC35D2 SLCO1A2 SLC28A1 SLCO1B3 SLC29A1	7.54e-08	43	72	6	M881
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC22A18 SLCO1C1 SLC24A4 SLC36A4 SLC35D2 SLCO1A2 SLC44A2 SLC28A1 SLCO1B3 SLC29A1	3.34e-07	238	72	10	MM15076
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC22A18 SLCO1C1 SLC24A4 SLC36A4 SLC35D2 SLCO1A2 SLC44A2 SLC28A1 SLCO1B3 SLC29A1	5.06e-07	249	72	10	M5988
Pathway	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	NPFFR2 NPY1R MC2R NMUR1 F2RL1 NMS CX3CR1 HCRTR1 CXCR2	6.74e-07	197	72	9	M12289
Pathway	REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS	NPFFR2 NPY1R MC2R NMUR1 F2RL1 NMS CX3CR1 HCRTR1 CXCR2	6.74e-07	197	72	9	MM14970
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	NPY1R ADRA2B HCAR1 NMUR1 TAS2R30 GRM7 GRM8 NMS CX3CR1 CXCR2	1.96e-06	289	72	10	MM15057
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	NPY1R ADRA2B HCAR1 NMUR1 TAS2R30 GRM7 GRM8 NMS CX3CR1 CXCR2	4.11e-06	314	72	10	M600
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC22A18 SLCO1C1 SLC24A4 SLC36A4 SLC35D2 SLCO1A2 SLC44A2 SLC28A1 MTTP ABCC11 SLCO1B3 ATP11C SLC29A1 SLC22A17	1.76e-05	736	72	14	M27287
Pathway	REACTOME_TRANSPORT_OF_ORGANIC_ANIONS	SLCO1C1 SLCO1A2 SLCO1B3	2.05e-05	11	72	3	M930
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	CACNA1A CACNA1B CACNA1E	2.05e-05	11	72	3	M47958
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNA1A CACNA1B CACNA1E	2.05e-05	11	72	3	MM14498
Pathway	REACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING	CACNA1A CACNA1B CACNA1E	2.05e-05	11	72	3	M26913
Pathway	REACTOME_TRANSPORT_OF_ORGANIC_ANIONS	SLCO1C1 SLCO1A2 SLCO1B3	2.72e-05	12	72	3	MM15476
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	SLC22A18 SLCO1C1 SLC24A4 SLC36A4 SLC35D2 SLCO1A2 SLC44A2 SLC28A1 MTTP SLCO1B3 ATP11C SLC29A1 SLC22A17	3.53e-05	681	72	13	MM14985
Pathway	WP_PEPTIDE_GPCRS	NPY1R MC2R CX3CR1 HCRTR1 CXCR2	3.95e-05	75	72	5	M39696
Pathway	WP_GPCRS_OTHER	OR6C2 GPR135 OR2F1 GRM8 CXCR2	1.11e-04	93	72	5	M39629
Pathway	WP_GPCRS_ODORANT	CMKLR2 HCAR1 OR5B21 GPR137B GPR135 TAS2R30	1.48e-04	157	72	6	MM15872
Pathway	KEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1A CACNA1B CACNA1E	2.10e-04	23	72	3	M47666
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL	CACNA1A CACNA1B CACNA1E	2.71e-04	25	72	3	M47948
Pathway	WP_GPCRS_PEPTIDE	NPY1R MC2R CX3CR1 CXCR2	4.45e-04	70	72	4	MM15959
Pathway	REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 HTR3C CHRND	4.46e-04	270	72	7	M15514
Pathway	REACTOME_OREXIN_AND_NEUROPEPTIDES_FF_AND_QRFP_BIND_TO_THEIR_RESPECTIVE_RECEPTORS	NPFFR2 HCRTR1	7.06e-04	8	72	2	M27291
Pathway	REACTOME_OREXIN_AND_NEUROPEPTIDES_FF_AND_QRFP_BIND_TO_THEIR_RESPECTIVE_RECEPTORS	NPFFR2 HCRTR1	7.06e-04	8	72	2	MM14995
Pathway	REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 CHRND	7.19e-04	211	72	6	MM14502
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	TAS2R30 GRM7 GRM8	8.76e-04	37	72	3	MM15067
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	TAS2R30 GRM7 GRM8	1.02e-03	39	72	3	M793
Pathway	REACTOME_TRANSPORT_OF_NUCLEOSIDES_AND_FREE_PURINE_AND_PYRIMIDINE_BASES_ACROSS_THE_PLASMA_MEMBRANE	SLC28A1 SLC29A1	1.37e-03	11	72	2	MM15471
Pathway	REACTOME_TRANSPORT_OF_NUCLEOSIDES_AND_FREE_PURINE_AND_PYRIMIDINE_BASES_ACROSS_THE_PLASMA_MEMBRANE	SLC28A1 SLC29A1	1.64e-03	12	72	2	M27728
Pathway	REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA6 CHRND	1.64e-03	12	72	2	M48008
Pathway	KEGG_TYPE_II_DIABETES_MELLITUS	CACNA1A CACNA1B CACNA1E	1.76e-03	47	72	3	M19708
Pathway	WP_SYNAPTIC_VESICLE_PATHWAY	SLC6A4 CACNA1A CACNA1B	2.23e-03	51	72	3	M39457
Pathway	WP_SULFATASE_AND_AROMATASE_PATHWAY	SLCO1A2 SLCO1B3	2.25e-03	14	72	2	M48085
Pathway	REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS	CHRNA6 CHRND	2.25e-03	14	72	2	M757
Pathway	WP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE	GRM7 GRM8	2.59e-03	15	72	2	M39442
Pathway	REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS	CHRNA6 CHRND	2.59e-03	15	72	2	MM14704
Pathway	WP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE	GRM7 GRM8	2.59e-03	15	72	2	MM15845
Pathway	REACTOME_SENSORY_PERCEPTION	OR2W3 OR2F2 TAS2R30 PPEF1 OR2F1	2.85e-03	190	72	5	MM15687
Pathway	REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS	SLCO1A2 SLCO1B3	3.73e-03	18	72	2	M4862
Pathway	REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS	SLCO1A2 SLCO1B3	4.16e-03	19	72	2	MM14612
Pathway	REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS	NPFFR2 NMUR1 F2RL1 NMS HCRTR1	4.36e-03	210	72	5	MM15043
Pathway	REACTOME_NEURONAL_SYSTEM	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 HTR3C CHRND	4.91e-03	411	72	7	M735
Pathway	REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS	NPFFR2 NMUR1 F2RL1 NMS HCRTR1	5.01e-03	217	72	5	M18437
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2W3 OR2F2 OR2F1	5.47e-03	70	72	3	MM14984
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR2W3 OR2F2 OR8J3 OR11G2 OR6C2 OR5B21 OR1L6 OR4D11 OR2F1 OR13J1 OR6X1 OR8G2P OR2A2	2.33e-12	340	85	13	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR2W3 OR2F2 OR8J3 OR11G2 OR6C2 OR5B21 OR1L6 OR4D11 OR2F1 OR13J1 OR6X1 OR8G2P OR2A2	2.33e-12	340	85	13	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR2W3 OR2F2 OR8J3 OR11G2 OR6C2 OR5B21 OR1L6 OR4D11 OR2F1 OR13J1 OR6X1 OR8G2P OR2A2	2.60e-12	343	85	13	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR2W3 OR2F2 OR8J3 OR11G2 OR6C2 OR5B21 OR1L6 OR4D11 OR2F1 OR13J1 OR6X1 OR8G2P OR2A2	2.90e-12	346	85	13	14611657
Pubmed	The human olfactory receptor gene family.	OR2W3 OR2F2 OR8J3 OR10A7 OR11G2 OR1L6 OR4D11 OR2F1 OR2T11 OR13J1 OR6X1 OR8G2P OR2A2	7.20e-10	541	85	13	14983052
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR2W3 OR8J3 OR10A7 OR11G2 OR1L6 OR4D11 OR2F1 OR13J1 OR2A2	3.59e-09	219	85	9	12213199
Pubmed	The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.	CACNA1A CACNA1B CACNA1E	1.41e-08	3	85	3	38996073
Pubmed	Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.	CACNA1A CACNA1B CACNA1E	1.41e-08	3	85	3	24523520
Pubmed	Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.	CACNA1A CACNA1B CACNA1E	5.63e-08	4	85	3	32616470
Pubmed	Cerebellar granule cell signaling is indispensable for normal motor performance.	CACNA1A CACNA1B CACNA1E	5.63e-08	4	85	3	37141091
Pubmed	Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.	CACNA1A CACNA1B CACNA1E	1.40e-07	5	85	3	8825650
Pubmed	Chemokine receptors CXCR2 and CX3CR1 differentially regulate functional responses of bone-marrow endothelial progenitors during atherosclerotic plaque regression.	MTTP CX3CR1 CXCR2	1.40e-07	5	85	3	25765938
Pubmed	Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.	CACNA1A CACNA1B CACNA1E	1.40e-07	5	85	3	15451373
Pubmed	Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.	CACNA1A CACNA1B CACNA1E	1.40e-07	5	85	3	11296258
Pubmed	An action potential initiation mechanism in distal axons for the control of dopamine release.	CACNA1A CACNA1B CACNA1E	2.80e-07	6	85	3	35324301
Pubmed	Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.	CACNA1A CACNA1B CACNA1E	2.80e-07	6	85	3	12827191
Pubmed	Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.	CACNA1A CACNA1B CACNA1E	2.80e-07	6	85	3	9238069
Pubmed	Rebuilding essential active zone functions within a synapse.	CACNA1A CACNA1B CACNA1E	4.90e-07	7	85	3	35176221
Pubmed	Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters.	SLCO1C1 SLCO1A2 SLCO1B3	7.82e-07	8	85	3	19129463
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1A CACNA1B CACNA1E	1.17e-06	9	85	3	16382099
Pubmed	Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties.	SLCO1C1 SLCO1A2 SLCO1B3	2.29e-06	11	85	3	14579113
Pubmed	Functional disruption of pyrimidine nucleoside transporter CNT1 results in a novel inborn error of metabolism with high excretion of uridine and cytidine.	SLC28A1 SLC29A1	5.90e-06	2	85	2	30847922
Pubmed	Blocking the R-type (Cav2.3) Ca2+ channel enhanced morphine analgesia and reduced morphine tolerance.	CACNA1B CACNA1E	5.90e-06	2	85	2	15610184
Pubmed	Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels.	CACNA1A CACNA1B	5.90e-06	2	85	2	23426690
Pubmed	Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice.	CACNA1A CACNA1E	5.90e-06	2	85	2	16381801
Pubmed	Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus.	GRM7 GRM8	5.90e-06	2	85	2	23220400
Pubmed	No association between metabotropic glutamate receptors 7 and 8 (mGlur7 and mGlur8) gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individuals.	GRM7 GRM8	5.90e-06	2	85	2	11912074
Pubmed	Significant association of GRM7 and GRM8 genes with schizophrenia and major depressive disorder in the Han Chinese population.	GRM7 GRM8	5.90e-06	2	85	2	26655190
Pubmed	Altered sleep homeostasis after restraint stress in 5-HTT knock-out male mice: a role for hypocretins.	SLC6A4 HCRTR1	5.90e-06	2	85	2	20007481
Pubmed	Variability of gemcitabine accumulation and its relationship to expression of nucleoside transporters in peripheral blood mononuclear cells.	SLC28A1 SLC29A1	5.90e-06	2	85	2	22644860
Pubmed	Infection of microglia with Porphyromonas gingivalis promotes cell migration and an inflammatory response through the gingipain-mediated activation of protease-activated receptor-2 in mice.	F2RL1 CX3CR1	5.90e-06	2	85	2	28924232
Pubmed	Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers.	CACNA1A CACNA1B	5.90e-06	2	85	2	23376566
Pubmed	The differential expression of hCNT1 and hENT1 i n breast cancer and the possible impact on breast cancer therapy.	SLC28A1 SLC29A1	5.90e-06	2	85	2	20734919
Pubmed	5-HTTLPR status predictive of neocortical 5-HT4 binding assessed with [(11)C]SB207145 PET in humans.	SLC6A4 HTR4	5.90e-06	2	85	2	22584237
Pubmed	Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport studies.	SLC28A1 SLC29A1	5.90e-06	2	85	2	12097333
Pubmed	CaV 2.1 α1 subunit motifs that control presynaptic CaV 2.1 subtype abundance are distinct from CaV 2.1 preference.	CACNA1A CACNA1B	5.90e-06	2	85	2	38155373
Pubmed	Effects of ablation of N- and R-type Ca(2+) channels on pain transmission.	CACNA1B CACNA1E	5.90e-06	2	85	2	12074836
Pubmed	Expression of the nucleoside transporters hENT1 (SLC29) and hCNT1 (SLC28) in pediatric acute myeloid leukemia.	SLC28A1 SLC29A1	5.90e-06	2	85	2	32312148
Pubmed	Differential roles of mGlu(7) and mGlu(8) in amygdala-dependent behavior and physiology.	GRM7 GRM8	5.90e-06	2	85	2	23664812
Pubmed	Correlated gene expression encoding serotonin (5-HT) receptor 4 and 5-HT transporter in proximal colonic segments of mice across different colonization states and sexes.	SLC6A4 HTR4	5.90e-06	2	85	2	27072889
Pubmed	Epistasis between 5-HTTLPR and ADRA2B polymorphisms influences attentional bias for emotional information in healthy volunteers.	SLC6A4 ADRA2B	5.90e-06	2	85	2	21854681
Pubmed	Immunocytochemical detection of hENT1 and hCNT1 in normal tissues, lung cancer cell lines, and NSCLC patient samples.	SLC28A1 SLC29A1	5.90e-06	2	85	2	18600541
Pubmed	Expression analysis of P/Q-type Ca2+ channel alpha 1A subunit mRNA in olfactory mitral cell in N-type Ca2+ channel alpha 1B subunit gene-deficient mice.	CACNA1A CACNA1B	5.90e-06	2	85	2	15050706
Pubmed	Non-additive potentiation of glutamate release by phorbol esters and metabotropic mGlu7 receptor in cerebrocortical nerve terminals.	CACNA1B GRM7	5.90e-06	2	85	2	21143597
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1A CACNA1B CACNA1E	6.28e-06	15	85	3	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1A CACNA1B CACNA1E	6.28e-06	15	85	3	24453333
Pubmed	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	SLC6A4 CHRNA6 HTR4 GRM7 GRM8	1.09e-05	118	85	5	19156168
Pubmed	A common variant in DRD3 receptor is associated with autism spectrum disorder.	SLC6A4 NPY1R ABCA13 GRM8 HCRTR1	1.62e-05	128	85	5	19058789
Pubmed	Munc13-3 Is Required for the Developmental Localization of Ca2+ Channels to Active Zones and the Nanopositioning of Cav2.1 Near Release Sensors.	CACNA1A CACNA1B	1.77e-05	3	85	2	29466725
Pubmed	Postnatal ontogeny of Neuromedin S and its receptors NMUR1 and NMUR2 expression in mouse testis.	NMUR1 NMS	1.77e-05	3	85	2	36336170
Pubmed	Resequencing three candidate genes for major depressive disorder in a Dutch cohort.	SLC6A4 GRM7	1.77e-05	3	85	2	24278217
Pubmed	Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting.	CACNA1A CACNA1B	1.77e-05	3	85	2	24394417
Pubmed	The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics.	SLCO1A2 SLCO1B3	1.77e-05	3	85	2	19890249
Pubmed	HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms.	SLCO1A2 SLCO1B3	1.77e-05	3	85	2	20051929
Pubmed	Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel.	SLCO1A2 SLCO1B3	1.77e-05	3	85	2	24825069
Pubmed	Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci.	GRM7 GRM8	1.77e-05	3	85	2	33068816
Pubmed	Frequencies of single-nucleotide polymorphisms of SLCO1A2, SLCO1B3 and SLCO2B1 genes in a Finnish population.	SLCO1A2 SLCO1B3	1.77e-05	3	85	2	20560925
Pubmed	Alteration in placental expression of bile acids transporters OATP1A2, OATP1B1, OATP1B3 in intrahepatic cholestasis of pregnancy.	SLCO1A2 SLCO1B3	1.77e-05	3	85	2	22203093
Pubmed	Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells.	GRM7 GRM8	1.77e-05	3	85	2	9473604
Pubmed	Molecular moieties masking Ca2+-dependent facilitation of voltage-gated Cav2.2 Ca2+ channels.	CACNA1A CACNA1B	1.77e-05	3	85	2	29208674
Pubmed	Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.	CACNA1A CACNA1B	1.77e-05	3	85	2	26507659
Pubmed	Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors.	SLC28A1 SLC29A1	1.77e-05	3	85	2	15386342
Pubmed	Changes in 5-HT4 receptor and 5-HT transporter binding in olfactory bulbectomized and glucocorticoid receptor heterozygous mice.	SLC6A4 HTR4	1.77e-05	3	85	2	20060867
Pubmed	Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.	SLCO1A2 SLCO1B3	1.77e-05	3	85	2	10779507
Pubmed	A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP).	F2RL1 GRM8 CXCR2	1.82e-05	21	85	3	15452121
Pubmed	Impact of Oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain.	SLCO1C1 SLCO1B3	3.53e-05	4	85	2	22294745
Pubmed	Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons.	CACNA1A CACNA1B	3.53e-05	4	85	2	26283199
Pubmed	Regional differences in expression of TPH-1, SERT, 5-HT(3) and 5-HT(4) receptors in the human stomach and duodenum.	SLC6A4 HTR4	3.53e-05	4	85	2	17509016
Pubmed	Role of chemokines in the biology of natural killer cells.	CX3CR1 CXCR2	3.53e-05	4	85	2	11818437
Pubmed	Identification of neuromedin S and its possible role in the mammalian circadian oscillator system.	NMUR1 NMS	3.53e-05	4	85	2	15635449
Pubmed	Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs.	SLCO1A2 SLCO1B3	3.53e-05	4	85	2	20644253
Pubmed	A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C.	CACNA1A CACNA1B	3.53e-05	4	85	2	15728831
Pubmed	Digoxin is not a substrate for organic anion-transporting polypeptide transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a substrate for a sodium-dependent transporter expressed in HEK293 cells.	SLCO1A2 SLCO1B3	3.53e-05	4	85	2	21849517
Pubmed	Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues.	CX3CR1 CXCR2	3.53e-05	4	85	2	18347198
Pubmed	The MAP1B-LC1/UBE2L3 complex catalyzes degradation of cell surface CaV2.2 channels.	CACNA1A CACNA1B	3.53e-05	4	85	2	25483588
Pubmed	Interactions of Rabconnectin-3 with Cav2 calcium channels.	CACNA1A CACNA1B	3.53e-05	4	85	2	31253182
Pubmed	Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system.	NMUR1 NMS	3.53e-05	4	85	2	10899166
Pubmed	Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy.	SLC6A4 HCRTR1	3.53e-05	4	85	2	33247179
Pubmed	Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes.	SLC28A1 SLC29A1	3.53e-05	4	85	2	18635603
Pubmed	Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H.	FGD2 FGD4	3.53e-05	4	85	2	17564959
Pubmed	Distribution of group-III metabotropic glutamate receptors in the retina.	GRM7 GRM8	3.53e-05	4	85	2	17311335
Pubmed	Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking.	CX3CR1 CXCR2	3.53e-05	4	85	2	31039135
Pubmed	G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels.	CACNA1A CACNA1B	3.53e-05	4	85	2	15953418
Pubmed	Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder.	GRM7 GRM8	3.53e-05	4	85	2	17167337
Pubmed	Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.	SLCO1A2 SLCO1B3	3.53e-05	4	85	2	27777271
Pubmed	Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A.	SLC6A4 ADRA2B HTR4	4.42e-05	28	85	3	19352218
Pubmed	Cooperation between mast cells and neurons is essential for antigen-mediated bronchoconstriction.	SLC6A4 F2RL1	5.87e-05	5	85	2	19494266
Pubmed	Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients.	SLC28A1 SLC29A1	5.87e-05	5	85	2	17926640
Pubmed	Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer.	SLC28A1 SLC29A1	5.87e-05	5	85	2	20665488
Pubmed	Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit.	CACNA1A CACNA1B	5.87e-05	5	85	2	16787652
Pubmed	OATP1A/1B transporters affect irinotecan and SN-38 pharmacokinetics and carboxylesterase expression in knockout and humanized transgenic mice.	SLCO1A2 SLCO1B3	5.87e-05	5	85	2	24194565
Pubmed	Mast cells contribute to autoimmune inflammatory arthritis via their tryptase/heparin complexes.	F2RL1 CXCR2	5.87e-05	5	85	2	19109198
Pubmed	Astrocyte- and Neuron-Derived CXCL1 Drives Neutrophil Transmigration and Blood-Brain Barrier Permeability in Viral Encephalitis.	CX3CR1 CXCR2	5.87e-05	5	85	2	32937134
Pubmed	Polymorphisms of the nuclear receptor pregnane X receptor and organic anion transporter polypeptides 1A2, 1B1, 1B3, and 2B1 are not associated with breast cancer risk.	SLCO1A2 SLCO1B3	5.87e-05	5	85	2	20635135
Pubmed	Pias1 interaction and sumoylation of metabotropic glutamate receptor 8.	GRM7 GRM8	8.80e-05	6	85	2	16144832
Pubmed	Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.	SLCO1A2 SLCO1B3	8.80e-05	6	85	2	22232210
Pubmed	Characterization of serotonin neurotransmission in knockout mice: implications for major depression.	SLC6A4 HTR4	8.80e-05	6	85	2	23089640
Pubmed	Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease.	CX3CR1 CXCR2	8.80e-05	6	85	2	17672867
Pubmed	Cortical RORβ is required for layer 4 transcriptional identity and barrel integrity.	SLC6A4 THSD7A	8.80e-05	6	85	2	32851975
Pubmed	beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain.	CACNA1A CACNA1B	8.80e-05	6	85	2	10328888
Interaction	SIDT2 interactions	CAMLG TMEM63B ATP11C HTR3C SPPL2B SLC29A1 LCLAT1 CHRND	3.65e-08	140	72	8	int:SIDT2
Cytoband	Ensembl 112 genes in cytogenetic band chr12p12	SLCO1C1 SLCO1A2 SLC15A5 SLCO1B3	5.50e-05	113	83	4	chr12p12
Cytoband	7q35	OR2F2 OR2F1 OR2A2	1.40e-04	55	83	3	7q35
Cytoband	Ensembl 112 genes in cytogenetic band chr7q35	OR2F2 OR2F1 OR2A2	2.40e-04	66	83	3	chr7q35
Cytoband	12p12	SLCO1A2 SLCO1B3	2.49e-04	13	83	2	12p12
Cytoband	1q44	OR2W3 OR14I1 OR2T11	1.07e-03	110	83	3	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2W3 OR14I1 OR2T11	1.65e-03	128	83	3	chr1q44
Cytoband	11q12.1	OR8J3 OR5B21 OR4D11	3.17e-03	161	83	3	11q12.1
Cytoband	14q23.1	GPR135 TRMT5	3.31e-03	47	83	2	14q23.1
Cytoband	14q11.2	OR11G2 OR6J1 SLC22A17	4.33e-03	180	83	3	14q11.2
Cytoband	12q13.2	OR10A7 OR6C2	4.51e-03	55	83	2	12q13.2
GeneFamily	Solute carriers	SLC6A4 SLC22A18 SLCO1C1 SLC24A4 SLC36A4 SLC35D2 SLCO1A2 SLC44A2 SLC28A1 SLC15A5 SLCO1B3 SLC36A3 SLC35F2 SLC29A1 SLC22A17	2.84e-11	395	71	15	752
GeneFamily	Olfactory receptors, family 2	OR2W3 OR2F2 OR2F1 OR2T11 OR2A2	8.18e-05	113	71	5	149
GeneFamily	Calcium voltage-gated channel subunits	CACNA1A CACNA1B CACNA1E	1.41e-04	26	71	3	253
GeneFamily	Glutamate metabotropic receptors\|Protein phosphatase 1 regulatory subunits	GRM7 GRM8	4.19e-04	8	71	2	281
GeneFamily	Taste 2 receptors	TAS2R33 TAS2R36 TAS2R30	4.79e-04	39	71	3	1162
GeneFamily	Neuropeptide receptors	NPFFR2 NPY1R	6.70e-04	10	71	2	854
GeneFamily	Olfactory receptors, family 6	OR6C2 OR6J1 OR6X1	1.06e-03	51	71	3	153
GeneFamily	Cholinergic receptors nicotinic subunits	CHRNA6 CHRND	1.76e-03	16	71	2	173
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	FGD2 FGD4	6.57e-03	31	71	2	81
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_12\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CACNA1A CHRNA6 PPEF1 GRM7 CX3CR1	1.28e-05	161	83	5	1670108afc0af90861eb80a84e59995571c0da1b
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_12\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CACNA1A CHRNA6 PPEF1 GRM7 CX3CR1	1.28e-05	161	83	5	1d446f5ba57d84949823a35cbedaee8f448fe40f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1A CACNA1B CACNA1E TMC1 SLC28A1	1.52e-05	167	83	5	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1A CACNA1B CACNA1E NPY1R PLPPR1	1.52e-05	167	83	5	c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CMKLR2 YIPF5 NPY1R ADRA2B ATP11C	1.61e-05	169	83	5	7c994653b0d629dfb046755d6b678452de0a15d2
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Mgp_(Gkn3)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SLC6A4 ABCA13 PPEF1 F2RL1	1.69e-05	82	83	4	ea3bdd7b871269eacb81167c6cf59a0e21bf6d83
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Mgp_(Gkn3)--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SLC6A4 ABCA13 PPEF1 F2RL1	1.69e-05	82	83	4	72d5a55ca7c03e9c54f865524e206b288f242017
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Mgp_(Gkn3)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SLC6A4 ABCA13 PPEF1 F2RL1	1.69e-05	82	83	4	e500582511814a067852dc3bd78d19937c28ba60
ToppCell	facs-Marrow-T-cells-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WFS1 HCAR1 GPR137B GPR135 GRM8	1.71e-05	171	83	5	6a0fafb8fd9fc7671618eeb2bf528ce8ce86b794
ToppCell	facs-Marrow-T-cells-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WFS1 HCAR1 GPR137B GPR135 GRM8	1.71e-05	171	83	5	e02b5831768dbb1b68998b672e55c9680ab0cc86
ToppCell	facs-Marrow-B-cells-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E WFS1 SLC44A2 GPR137B GRM8	2.19e-05	180	83	5	bf8d13d4db1af55b8c9fe16aaccf8743e000e005
ToppCell	facs-Marrow-B-cells-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E WFS1 SLC44A2 GPR137B GRM8	2.19e-05	180	83	5	839defb40f7cfb2711e9025194de636533f51bcd
ToppCell	facs-Marrow-B-cells-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E WFS1 SLC44A2 GPR137B GRM8	2.19e-05	180	83	5	82965ed1b72a1873c24dd4553d39681596057316
ToppCell	Immune_cells-Dendritic_cells\|Immune_cells / Lineage and Cell class	FGD2 WFS1 SLC44A2 GPR137B GRM8	2.31e-05	182	83	5	99c7d4f1e7cd745643ba64b59190113bcd4e348e
ToppCell	10x5'-Lung-Lymphocytic_NK-NK_CD16\|Lung / Manually curated celltypes from each tissue	SLC44A2 NMUR1 COLQ CX3CR1 CXCR2	3.21e-05	195	83	5	e91e7f89163c615b706f3297b641b1e4c966f5e6
ToppCell	10x5'-Lung-Lymphocytic_NK\|Lung / Manually curated celltypes from each tissue	SLC44A2 NMUR1 COLQ CX3CR1 CXCR2	3.21e-05	195	83	5	a5a10ef9254c266316e5591bec19e159cc3caead
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CHRNA6 THSD7A ATP11C PLPPR1 HCRTR1	3.62e-05	200	83	5	53d5e427f0cbf5cf0b63efe4ec01da302f555704
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_1\|Thalamus / BrainAtlas - Mouse McCarroll V32	SLCO1C1 SLCO1B3 SLC35F2 F2RL1	5.17e-05	109	83	4	4e4a884b8979f4ff8b232c1581ea78884dda29ed
Computational	Genes in the cancer module 146.	CMKLR2 NPY1R ADRA2B HTR4 OR2F1 CX3CR1 HCRTR1	4.59e-08	102	37	7	MODULE_146
Computational	GPCR signaling pathways (immune and neuro).	NPY1R ADRA2B OR2F1 GRM8 CX3CR1 HCRTR1	5.49e-07	90	37	6	MODULE_375
Computational	Genes in the cancer module 289.	NPY1R ADRA2B OR2F1 GRM8 CX3CR1 HCRTR1	3.62e-06	124	37	6	MODULE_289
Computational	Genes in the cancer module 134.	NPY1R CX3CR1 HCRTR1	1.43e-04	30	37	3	MODULE_134
Computational	Genes in the cancer module 288.	NPY1R CX3CR1 CXCR2	2.69e-04	37	37	3	MODULE_288
Computational	Neighborhood of LMO1	HTR4 MC2R COLQ	7.39e-04	52	37	3	MORF_LMO1
Drug	AC 110	CACNA1A CACNA1B CACNA1E	1.80e-07	4	82	3	CID000022860
Drug	Fk 888	CACNA1A CACNA1B CACNA1E HTR4 F2RL1	4.10e-07	42	82	5	CID000107967
Drug	3,4-dihydroquinazoline	CACNA1A CACNA1B CACNA1E	8.94e-07	6	82	3	CID000583065
Drug	alpha-sialylcholesterol	CACNA1A CACNA1B CACNA1E	8.94e-07	6	82	3	CID000133976
Drug	alpha-conotoxin SI	CACNA1A CACNA1B CACNA1E CHRNA6	1.31e-06	23	82	4	CID000163979
Drug	APMPA	CACNA1A CACNA1B CACNA1E	1.56e-06	7	82	3	CID000512300
Drug	nefiracetam	CACNA1A CACNA1B CACNA1E CHRNA6 CHRND	1.77e-06	56	82	5	CID000071157
Drug	tetradotoxin	CACNA1A CACNA1B CACNA1E CHRNA6 ADRA2B HTR4 GRM7 F2RL1 GRM8 CHRND	3.18e-06	428	82	10	CID000020382
Drug	DCG-IV	CACNA1A CACNA1B CACNA1E GRM7 GRM8	4.67e-06	68	82	5	CID000115114
Drug	fluspirilene	CACNA1A CACNA1B CACNA1E ADRA2B	6.67e-06	34	82	4	CID000003396
Drug	leys	CACNA1A CACNA1B CACNA1E	7.28e-06	11	82	3	CID000484683
Drug	AC1L2VU3	CACNA1A CACNA1B CACNA1E	9.68e-06	12	82	3	CID000129572
Drug	3,4-diaminopyridine	CACNA1A CACNA1B CACNA1E CHRND	1.05e-05	38	82	4	CID000005918
Drug	4-aminopyrrolidine-2,4-dicarboxylate	CACNA1B CACNA1E GRM7 GRM8	1.17e-05	39	82	4	CID003331970
Drug	norcepharadione B	CACNA1B CACNA1E	1.28e-05	2	82	2	CID000189168
Drug	aristolactam AII	CACNA1B CACNA1E	1.28e-05	2	82	2	CID000148657
Drug	alkosin	CACNA1B CACNA1E	1.28e-05	2	82	2	CID005488638
Drug	piperolactam A	CACNA1B CACNA1E	1.28e-05	2	82	2	CID003081016
Drug	brimonidine	CACNA1A CACNA1B CACNA1E CHRNA6 ADRA2B	1.48e-05	86	82	5	CID000002435
Drug	hexachlorophene	CACNA1A CACNA1B CACNA1E GRM7 GRM8	1.85e-05	90	82	5	CID000003598
Drug	2-amino-4-phosphonobutyric acid	CACNA1A CACNA1B CACNA1E GRM7 GRM8	1.95e-05	91	82	5	CID000002207
Drug	butamben	CACNA1A CACNA1B CACNA1E	1.99e-05	15	82	3	CID000002482
Drug	Nicorette	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 HTR4 GRM7 GRM8 CHRND CXCR2	2.01e-05	529	82	10	CID000000942
Drug	pentasulfane	CACNA1A CACNA1B CACNA1E	2.44e-05	16	82	3	CID000448216
Drug	Verapamil	SLC6A4 CACNA1A CACNA1B	2.44e-05	16	82	3	DB00661
Drug	NSC755875	SLC6A4 CACNA1B CACNA1E CHRNA6 ADRA2B CHRND	2.94e-05	165	82	6	CID000002215
Drug	loperamide	CACNA1A CACNA1B CACNA1E HTR4 SLCO1A2	3.90e-05	105	82	5	CID000003954
Drug	5-fluorodeoxyuridine	SLC28A1 ABCC11 GRM7 GRM8 SLC29A1	4.08e-05	106	82	5	CID000003363
Drug	N6-Me-dAdo	CACNA1A CACNA1B CACNA1E	4.19e-05	19	82	3	CID000168948
Drug	pranidipine	CACNA1A CACNA1B CACNA1E	4.19e-05	19	82	3	CID006436048
Drug	aminocyclopentane	GRM7 GRM8 SLC29A1	4.19e-05	19	82	3	CID000002906
Drug	acetylcholine	SLC6A4 CACNA1B CACNA1E CHRNA6 ADRA2B HTR4 SLC44A2 CHRND	4.75e-05	361	82	8	CID000000187
Drug	amsonine	CACNA1A CACNA1B CACNA1E CHRNA6 ADRA2B HTR4	4.93e-05	181	82	6	CID000002866
Drug	dopamine	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 ADRA2B HTR4 GRM7 GRM8 SLC29A1 CHRND	5.00e-05	715	82	11	CID000000681
Drug	gamma-aminobutyric acid	SLC6A4 CACNA1A CACNA1B CACNA1E CHRNA6 HTR4 GRM7 GRM8 CX3CR1	5.20e-05	474	82	9	CID000000119
Drug	guanethidine	CACNA1A CACNA1B CACNA1E CHRNA6 ADRA2B	5.54e-05	113	82	5	CID000003518
Drug	SR 48968	CACNA1B CACNA1E HTR4 PTCHD3	5.72e-05	58	82	4	CID000104974
Drug	morphine hydrochloride	CACNA1A CACNA1B NPFFR2 CACNA1E SLC22A18 GRM7 GRM8 CX3CR1 CXCR2	5.82e-05	481	82	9	CID000004253
Drug	thioridazine hydrochloride; Up 200; 10uM; HL60; HT_HG-U133A	CHRNA6 FGD2 SLC35D2 SLC28A1 SPPL2B SLC22A17	7.04e-05	193	82	6	6189_UP
Drug	EGTA-AM	CACNA1A CACNA1B CACNA1E XPO1	7.44e-05	62	82	4	CID000121907
Drug	LY320135	CACNA1A CACNA1B CACNA1E	7.57e-05	23	82	3	CID005311257
Drug	ABT-418	CACNA1B CACNA1E CHRNA6	7.57e-05	23	82	3	CID000119380
Drug	Dihydromicrocystin Lr	SLCO1A2 SLCO1B3	7.65e-05	4	82	2	CID006441227
Drug	Nitrarine dihydrochloride [20069-05-0]; Up 200; 10.6uM; PC3; HT_HG-U133A	CACNA1A SLC28A1 NMUR1 PPEF1 GRM8 HCRTR1	7.89e-05	197	82	6	3683_UP
Drug	PrBCM	CACNA1A CHRNA6 CHRND	9.78e-05	25	82	3	CID000037396
Drug	sodium glycocholate	SLCO1A2 SLC28A1 ABCC11 SLCO1B3	1.13e-04	69	82	4	CID000000755
Drug	mAHP	CACNA1A CACNA1B CACNA1E	1.24e-04	27	82	3	CID000220531
Drug	eniluracil	CACNA1A CACNA1B CACNA1E	1.24e-04	27	82	3	CID000043157
Drug	almagel	CACNA1B CACNA1E	1.27e-04	5	82	2	CID003080942
Drug	S 8510	CACNA1A CACNA1B	1.27e-04	5	82	2	CID005488383
Drug	Barium	CACNA1A CACNA1B CACNA1E F2RL1	1.33e-04	72	82	4	ctd:D001464
Drug	Virginiamycin S1	CACNA1B CACNA1E SLC22A18	1.38e-04	28	82	3	CID000122731
Drug	AC1L1KC5	CACNA1A CACNA1B CACNA1E CHRNA6 WFS1 CAMLG GRM7 F2RL1 GRM8	1.42e-04	541	82	9	CID000005428
Drug	1,3-dipropylxanthine	CACNA1A CACNA1B CACNA1E GRM8	1.48e-04	74	82	4	CID000169317
Drug	myo-inositol	CACNA1A CACNA1B CMKLR2 CACNA1E CHRNA6 ADRA2B HTR4 HCAR1 GRM7 GRM8 CHRND	1.53e-04	811	82	11	CID000000892
Drug	glufosinate	CACNA1A CACNA1B CACNA1E GRM8	1.65e-04	76	82	4	CID000004794
Drug	BAPTA	CACNA1A CACNA1B CMKLR2 CACNA1E CHRNA6 GRM7 GRM8	1.69e-04	324	82	7	CID000104751
Drug	muscarine	CACNA1B CHRNA6 HTR4 SLC24A4 CHRND	1.74e-04	144	82	5	CID000009308
Drug	carbachol	CACNA1A CACNA1B NPFFR2 CACNA1E CHRNA6 ADRA2B HTR4 GRM7 GRM8 CHRND	1.79e-04	688	82	10	CID000002551
Drug	Dantrolene-13C3	CACNA1A CACNA1B CACNA1E GRM7 GRM8	1.80e-04	145	82	5	CID000002951
Drug	nimodipine	CACNA1A CACNA1B CACNA1E GRM7 GRM8	1.80e-04	145	82	5	CID000004497
Drug	nicardipine	CACNA1A CACNA1B CACNA1E CHRNA6 CHRND	1.80e-04	145	82	5	CID000004473
Drug	hemicholinium-3	SLC6A4 CHRNA6 SLC44A2 CHRND	1.82e-04	78	82	4	CID000003585
Drug	trospium chloride	SLCO1A2 SLCO1B3	1.90e-04	6	82	2	ctd:C003330
Drug	prednisolone phosphate	SLCO1A2 SLCO1B3	1.90e-04	6	82	2	CID000004896
Drug	3-(1H-pyrrole-2-carboxylate	CACNA1A CACNA1B CACNA1E SLC24A4 GRM7 GRM8	1.97e-04	233	82	6	CID000005114
Drug	AC1L1KS5	CACNA1A CACNA1B CMKLR2 CACNA1E GRM7 F2RL1 GRM8	2.03e-04	334	82	7	CID000005631
Drug	17beta-estradiol glucuronide	SLCO1C1 SLCO1A2 SLCO1B3	2.07e-04	32	82	3	CID000066424
Drug	3-aminopropylphosphinic acid	CACNA1A CACNA1B CACNA1E	2.07e-04	32	82	3	CID006335948
Drug	pseudococaine	SLC6A4 CHRNA6 ADRA2B HTR4 GRM7 GRM8 CX3CR1 CHRND CXCR2	2.10e-04	570	82	9	CID000002826
Drug	A61603	CACNA1A CACNA1B ADRA2B	2.27e-04	33	82	3	CID004038180
Drug	CNS 1145	CACNA1A CACNA1B CACNA1E	2.27e-04	33	82	3	CID000190902
Drug	IHC-64	CACNA1A CACNA1B CACNA1E	2.27e-04	33	82	3	CID000162753
Drug	GF109203X	CACNA1A CACNA1B CMKLR2 CACNA1E GRM7 GRM8 SLC29A1	2.31e-04	341	82	7	CID000002396
Drug	procaine	CACNA1A CACNA1B CACNA1E CHRNA6 CHRND	2.31e-04	153	82	5	CID000004914
Drug	Substance P	CACNA1B CACNA1E CHRNA6 NPY1R HTR4 F2RL1 CHRND	2.39e-04	343	82	7	CID000036511
Drug	capsazepine	CACNA1A CACNA1B CACNA1E F2RL1	2.42e-04	84	82	4	CID002733484
Drug	XeC compound	CACNA1B CACNA1E F2RL1 GRM8	2.42e-04	84	82	4	CID000005701
Drug	Cytidine	SLC28A1 SLC29A1	2.66e-04	7	82	2	ctd:D003562
Drug	demethylphalloin	SLCO1C1 SLCO1B3	2.66e-04	7	82	2	CID000114793
Drug	IPSP	CACNA1B CACNA1E GRM7 GRM8	2.77e-04	87	82	4	CID000022083
Drug	3-7a	CACNA1A CACNA1B CACNA1E	2.95e-04	36	82	3	CID011987860
Drug	CP-80	CACNA1A CACNA1B CACNA1E	2.95e-04	36	82	3	CID000452640
Drug	bethanechol	CHRNA6 ADRA2B HTR4 CHRND	3.16e-04	90	82	4	CID000002370
Drug	sipatrigine	SLC6A4 CACNA1B CACNA1E	3.20e-04	37	82	3	CID000060803
Drug	DAPs	CACNA1A CACNA1B CACNA1E XPO1	3.43e-04	92	82	4	CID000146339
Drug	8-cyclopentyltheophylline	CACNA1A CACNA1B CACNA1E	3.47e-04	38	82	3	CID000001917
Drug	3,5-diiodo-L-thyronine	SLCO1C1 SLCO1A2 SLCO1B3	3.47e-04	38	82	3	CID000092859
Drug	cis-MCG-I	GRM7 GRM8	3.54e-04	8	82	2	CID003035584
Drug	NSC263652	SLCO1A2 SLCO1B3	3.54e-04	8	82	2	CID000429721
Drug	Prestwick_523	SLC35D2 RTL1 SLC29A1	3.75e-04	39	82	3	CID000003687
Drug	verapamil	CACNA1A CACNA1B CACNA1E CHRNA6 ADRA2B ABCA13 SLCO1A2 CHRND	3.84e-04	490	82	8	CID000002520
Drug	epps	CACNA1B CACNA1E PTCHD3	4.04e-04	40	82	3	CID000085255
Drug	riluzole	CACNA1A CACNA1B CACNA1E GRM7 GRM8	4.18e-04	174	82	5	CID000005070
Drug	BMY 7378	CACNA1A CACNA1B ADRA2B	4.35e-04	41	82	3	CID000002419
Drug	AC1L1I54	CACNA1A CACNA1B CACNA1E	4.35e-04	41	82	3	CID000004426
Drug	AC1N21PP	GRM7 GRM8	4.54e-04	9	82	2	CID004014619
Drug	1,3-cyclopentanedicarboxylic acid	GRM7 GRM8	4.54e-04	9	82	2	CID000107216
Drug	pozanicline	CHRNA6 CHRND	4.54e-04	9	82	2	ctd:C108326
Drug	mM PEP	GRM7 GRM8	4.54e-04	9	82	2	CID005311462
Disease	familial hemiplegic migraine 1 (implicated_via_orthology)	CACNA1A CACNA1B CACNA1E	1.58e-08	3	75	3	DOID:0111181 (implicated_via_orthology)
Disease	migraine (implicated_via_orthology)	CACNA1A CACNA1B CACNA1E	6.30e-08	4	75	3	DOID:6364 (implicated_via_orthology)
Disease	Bipolar Disorder	SLC6A4 CACNA1A CACNA1B CHRNA6 THSD7A HTR4 ABCA13 WFS1 MC2R GRM7	3.60e-07	477	75	10	C0005586
Disease	hereditary ataxia (implicated_via_orthology)	CACNA1A CACNA1B CACNA1E	5.48e-07	7	75	3	DOID:0050951 (implicated_via_orthology)
Disease	Depressive disorder	SLC6A4 CHRNA6 NPY1R SLCO1C1 HTR4 WFS1 GRM7 HCRTR1	7.35e-07	289	75	8	C0011581
Disease	Mental Depression	SLC6A4 CHRNA6 SLCO1C1 HTR4 WFS1 GRM7 HCRTR1	3.89e-06	254	75	7	C0011570
Disease	Charcot-Marie-Tooth disease type 4H (implicated_via_orthology)	FGD2 FGD4	3.81e-05	4	75	2	DOID:0110192 (implicated_via_orthology)
Disease	X-linked Aarskog syndrome (implicated_via_orthology)	FGD2 FGD4	3.81e-05	4	75	2	DOID:6683 (implicated_via_orthology)
Disease	epilepsy (implicated_via_orthology)	CACNA1A CACNA1B CACNA1E SLC24A4 GRM8	6.11e-05	163	75	5	DOID:1826 (implicated_via_orthology)
Disease	childhood absence epilepsy (implicated_via_orthology)	CACNA1A NPY1R	9.50e-05	6	75	2	DOID:1825 (implicated_via_orthology)
Disease	Anxiety States, Neurotic	SLC6A4 NPY1R GRM8	1.94e-04	44	75	3	C0376280
Disease	Anxiety Disorders	SLC6A4 NPY1R GRM8	1.94e-04	44	75	3	C0003469
Disease	Anxiety neurosis (finding)	SLC6A4 NPY1R GRM8	1.94e-04	44	75	3	C1279420
Disease	response to topoisomerase inhibitor, response to antineoplastic agent	THSD7A GRM7	2.27e-04	9	75	2	GO_0072758, GO_0097327
Disease	hexadecenedioate (C16:1-DC) measurement	SLCO1A2 SLCO1B3	2.27e-04	9	75	2	EFO_0800562
Disease	X-21467 measurement	SLCO1C1 SLCO1B3	2.27e-04	9	75	2	EFO_0020007
Disease	gastric adenocarcinoma (is_implicated_in)	ABCA13 XPO1	3.45e-04	11	75	2	DOID:3717 (is_implicated_in)
Disease	ecosanoids measurement	SLCO1C1 SLCO1A2 SLCO1B3	3.76e-04	55	75	3	EFO_0020044
Disease	Withdrawal Symptoms	SLC6A4 CHRNA6 HCRTR1	4.40e-04	58	75	3	C0087169
Disease	Drug Withdrawal Symptoms	SLC6A4 CHRNA6 HCRTR1	4.40e-04	58	75	3	C0086189
Disease	Substance Withdrawal Syndrome	SLC6A4 CHRNA6 HCRTR1	4.40e-04	58	75	3	C0038587
Disease	glycochenodeoxycholate glucuronide (1) measurement	SLCO1A2 SLCO1B3	4.88e-04	13	75	2	EFO_0800474
Disease	Alcoholic Intoxication, Chronic	SLC6A4 SLC22A18 GRM7 GRM8 SLC29A1	6.12e-04	268	75	5	C0001973
Disease	Rolandic epilepsy	DPY19L2 PTCHD3	7.48e-04	16	75	2	Orphanet_1945
Disease	congenital myasthenic syndrome (implicated_via_orthology)	CHRNA6 CHRND	7.48e-04	16	75	2	DOID:3635 (implicated_via_orthology)
Disease	Mood Disorders	SLC6A4 HTR4 WFS1 HCRTR1	9.00e-04	168	75	4	C0525045
Disease	daytime rest measurement	CACNA1A NPY1R DENND3 CX3CR1 HCRTR1	9.41e-04	295	75	5	EFO_0007828
Disease	borna disease (biomarker_via_orthology)	SLC6A4 CX3CR1	9.50e-04	18	75	2	DOID:5154 (biomarker_via_orthology)
Disease	attention deficit hyperactivity disorder (is_implicated_in)	SLC6A4 GRM8	1.18e-03	20	75	2	DOID:1094 (is_implicated_in)
Disease	Attention Deficit Disorder	GRM7 GRM8	1.42e-03	22	75	2	C0041671
Disease	depressive disorder (implicated_via_orthology)	SLC6A4 NPY1R	1.42e-03	22	75	2	DOID:1596 (implicated_via_orthology)
Disease	Minimal Brain Dysfunction	GRM7 GRM8	1.42e-03	22	75	2	C1321905
Disease	anxiety disorder (implicated_via_orthology)	SLC6A4 NPY1R	1.42e-03	22	75	2	DOID:2030 (implicated_via_orthology)
Disease	obesity (is_implicated_in)	ADRA2B MTTP CX3CR1	1.63e-03	91	75	3	DOID:9970 (is_implicated_in)
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	FGD2 FGD4	1.70e-03	24	75	2	DOID:10595 (implicated_via_orthology)
Disease	Myasthenic Syndromes, Congenital	COLQ CHRND	1.70e-03	24	75	2	C0751882
Disease	Attention deficit hyperactivity disorder	GRM7 GRM8	1.70e-03	24	75	2	C1263846
Disease	Schizophrenia	SLC6A4 CACNA1B NPY1R HTR4 ABCA13 GRM7 GRM8 HCRTR1	1.79e-03	883	75	8	C0036341
Disease	obsessive-compulsive disorder	SLCO1C1 GPR135 SLCO1B3	2.14e-03	100	75	3	EFO_0004242
Disease	primary biliary cholangitis (biomarker_via_orthology)	SLCO1C1 SLCO1A2	2.31e-03	28	75	2	DOID:12236 (biomarker_via_orthology)
Disease	Autosomal dominant nonsyndromic hearing loss	TMC1 WFS1	2.48e-03	29	75	2	cv:C5779548
Disease	Parkinsonism (implicated_via_orthology)	GRM8 CX3CR1	2.48e-03	29	75	2	DOID:0080855 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QSFKALPYVCLLIAM	CACNA1A	1686	O00555
LSIFAPFLTLQLAYM	CAMLG	211	P49069
PCVLISFMVNLVFYL	CHRND	256	Q07001
ALPYVCLLIAMLFFI	CACNA1E	1606	Q15878
YVSLNFIFGLCTMLI	ABCA13	4571	Q86UQ4
PLISVYFALCLSLMV	HTR3C	306	Q8WXA8
FFAPCLIMILVYLRI	ADRA2B	181	P18089
NFLGFLLPLLIMSYC	CX3CR1	196	P49238
LTLVTECFMAYLYPL	DENND3	226	A2RUS2
PFEYMILATIIANCI	CACNA1B	96	Q00975
FKALPYVCLLIAMLF	CACNA1B	1596	Q00975
VLVLYAIFLCFSIMI	SLC24A4	591	Q8NFF2
FANIYLAPLSLIVIM	NPFFR2	326	Q9Y5X5
FTTVCIPRFLYNISM	OR6C2	71	Q9NZP2
YVAICSPLLYNVIMS	OR8G2P	136	Q6IF36
VLFLFLCLVYMTTLL	OR4D11	26	Q8NGI4
PMTLGIYLQLFFLSI	COLQ	6	Q9Y215
FIMFPFCLILVSYTR	OR10A7	206	Q8NGE5
ILISYFFICITIQRM	OR5B21	211	A6NL26
ILAIYCFCMLQIPSS	NMS	11	Q5H8A3
QTELFMPICATYLLI	NMUR1	56	Q9HB89
FSPAMCLLIYLYSLV	LCLAT1	356	Q6UWP7
TISYMGCAIQLFLFL	OR2W3	91	Q7Z3T1
MILLAVLFLCFISSY	MTTP	1	P55157
IVPLLIMLFCYGFTL	CXCR2	221	P25025
LFNNMLLYCVPKFSL	FGD4	446	Q96M96
AILCYLLVFPLAVFM	ABCC11	306	Q96J66
LLMTPFCLVLLSYIQ	OR2F1	206	Q13607
LLMTPFCLVLLSYIR	OR2F2	206	O95006
LLFPLCSAMYLVTLL	OR13J1	26	Q8NGT2
FSYPFLVLQMCILTL	DPY19L2	301	Q6NUT2
PLFLVFLVLYVLTMA	OR8J3	26	Q8NGG0
PRLQIPMYFFLCNLS	OR6X1	51	Q8NH79
LTGIFLCYSITFLMI	GRM8	626	O00222
ISFVPCIMQTFLYLA	OR2A2	91	Q6IF42
DLLVAIMCLPFTFVY	NPY1R	86	P25929
TVLAMYLICFTPSNL	F2RL1	291	P55085
MVVLLVFALCYLPIS	HCRTR1	301	O43613
MFYTINLIIPCLFIS	CHRNA6	241	Q15825
LVVACYLLPFLLMCF	GPR135	281	Q8IZ08
HKCYTFLIFMVLLLP	TMEM63B	516	Q5T3F8
CSVVAFYIPFLLMVL	HTR4	196	Q13639
SYNSVFPMVYCILLL	MBOAT4	411	Q96T53
LFLFNNMLLYCVPRV	FGD2	341	Q7Z6J4
IFLCYIITFLMIAKP	GRM7	636	Q14831
FIMVVAIVFITCYLP	HCAR1	221	Q9BXC0
YVMCSLLYPLVTFFL	SLC44A2	356	Q8IWA5
SSMPCFYLILQYVLL	SLC15A5	426	A6NIM6
MFIVSLLLIPYPLCS	PTCHD3	811	Q3KNS1
PSFQCALYLIRLLMV	FANCD2	1126	Q9BXW9
PMYILLANFSFLEIC	OR11G2	96	Q8NGC1
FVACGIQIFLYLTMI	OR2T11	91	Q8NH01
EILMILCVSFLVYPN	PPEF1	211	O14829
TPFLCIIFSYLRIMV	OR1L6	246	Q8NGR2
FSTCSPQLIVIMLFL	OR14I1	236	A6ND48
NILMPALTILASYIF	OR8G3P	206	P0DMU2
PVCLQFFTLTLMNLY	GPR137B	121	O60478
FIVLCQLTLQSYPRM	RTL1	216	A6NKG5
VTSFLLLCAIYFLSM	TAS2R30	231	P59541
VISFLMLCAIYFLSI	TAS2R33	231	P0DSN6
VTSFLLLCAIYFLSM	TAS2R36	231	P0DTE0
FYNACFMIIPTLIIS	SLC35D2	206	Q76EJ3
MLCITFQIPASVLYK	TRMT5	461	Q32P41
FVLLIFIVSMIYLAC	THSD7A	1616	Q9UPZ6
CLLVVSYQQPLSIFM	TMEM121B	486	Q9BXQ6
LQRMITAPCILFLFY	SLC22A17	216	Q8WUG5
SLSCNPIYMLFILVS	SLCO1A2	311	P46721
TPMLQSFINYCLLFL	SLC35F2	71	Q8IXU6
YSIIPCFIFVELVIM	PLPPR1	11	Q8TBJ4
TPMYFFLCNLSILDI	OR6J1	56	Q8NGC5
ELTCLFMQFSIVPYL	SLC22A18	36	Q96BI1
LCAMLPLLLFTYLNS	SLC29A1	86	Q99808
LLVITQLGFCSVYFM	SLC36A3	141	Q495N2
FRLPLSYFLVGIMCI	TMC1	271	Q8TDI8
LFPLMLVFILCLYVH	MC2R	181	Q01718
FIIGYLFPLLTMSIC	CMKLR2	211	P46091
LTMYNICFTSLPILA	ATP11C	911	Q8NB49
YFVFCLQIIISIGLM	TMEM64	311	Q6YI46
LISTLIYKFLNVPMF	XPO1	246	O14980
GCPQMFLYFLVISVI	SLCO1C1	546	Q9NYB5
MISFLFQLLYFPLIC	SLCO1B3	416	Q9NPD5
AFCLYMLKTIRLPTF	SPPL2B	331	Q8TCT7
YCLLPMILLSSFAVI	YIPF5	186	Q969M3
QLICSYILRPVAFLM	SLC28A1	461	O00337
ALCIMLIFTVIYFSI	SLC6A4	256	P31645
SVDLRIYMLCFLPFI	SLC36A4	206	Q6YBV0
IYMLCFLPFIILLVF	SLC36A4	211	Q6YBV0
PLVIFYLSFISMVIC	WFS1	346	O76024