Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
MousePhenoabnormal T wave

DSP MYPN SCN5A

5.59e-069583MP:0010505
DomainRASGEF_CAT

RAPGEF6 RAPGEF2 RAPGEFL1

2.19e-0429763PS50009
DomainRasGEF

RAPGEF6 RAPGEF2 RAPGEFL1

2.43e-0430763PF00617
Domain-

RAPGEF6 RAPGEF2 RAPGEFL1

2.43e-04307631.10.840.10
DomainRas_GEF_dom

RAPGEF6 RAPGEF2 RAPGEFL1

2.43e-0430763IPR023578
DomainRASGEF_cat_dom

RAPGEF6 RAPGEF2 RAPGEFL1

2.43e-0430763IPR001895
DomainRasGEF

RAPGEF6 RAPGEF2 RAPGEFL1

2.43e-0430763SM00147
DomaincNMP

RAPGEF6 PNPLA6 RAPGEF2

3.54e-0434763SM00100
DomaincNMP_binding

RAPGEF6 PNPLA6 RAPGEF2

3.54e-0434763PF00027
DomaincNMP-bd_dom

RAPGEF6 PNPLA6 RAPGEF2

3.86e-0435763IPR000595
DomainCNMP_BINDING_3

RAPGEF6 PNPLA6 RAPGEF2

3.86e-0435763PS50042
DomainEGF

PCSK5 EYS CNTNAP5 ATRAID CRELD2 UMOD

3.90e-04235766SM00181
DomaincNMP-bd-like

RAPGEF6 PNPLA6 RAPGEF2

4.93e-0438763IPR018490
DomainEGF-like_dom

PCSK5 EYS CNTNAP5 ATRAID CRELD2 UMOD

5.30e-04249766IPR000742
Domain-

RAPGEF6 PNPLA6 RAPGEF2

9.82e-04487632.60.120.10
DomainRmlC-like_jellyroll

RAPGEF6 PNPLA6 RAPGEF2

1.17e-0351763IPR014710
DomainMyosin_tail_1

CGN MYH15

2.40e-0318762PF01576
DomainMyosin_tail

CGN MYH15

2.40e-0318762IPR002928
DomainFurin_repeat

PCSK5 CRELD2

2.40e-0318762IPR006212
DomainFU

PCSK5 CRELD2

2.40e-0318762SM00261
DomainTPR-like_helical_dom

ZHX1-C8orf76 IFT140 TRANK1 TTC28 C8orf76

2.61e-03233765IPR011990
DomainEGF_3

EYS CNTNAP5 ATRAID CRELD2 UMOD

2.70e-03235765PS50026
DomainRasGEFN

RAPGEF6 RAPGEF2

2.96e-0320762SM00229
DomainRasGEF_N

RAPGEF6 RAPGEF2

3.26e-0321762PF00618
DomainRas-like_Gua-exchang_fac_N

RAPGEF6 RAPGEF2

3.58e-0322762IPR000651
DomainRASGEF_NTER

RAPGEF6 RAPGEF2

3.58e-0322762PS50212
DomainGrowth_fac_rcpt_

PCSK5 EYS CRELD2 UMOD

3.77e-03156764IPR009030
DomainEGF_1

EYS CNTNAP5 ATRAID CRELD2 UMOD

3.83e-03255765PS00022
DomainEGF_2

EYS CNTNAP5 ATRAID CRELD2 UMOD

4.51e-03265765PS01186
DomainIQ

MYO15B SCN5A MYH15

6.46e-0393763PS50096
DomainRA

RAPGEF6 RAPGEF2

7.04e-0331762SM00314
DomainEGF_Ca-bd_CS

EYS CRELD2 UMOD

7.26e-0397763IPR018097
DomainEGF_CA

EYS CRELD2 UMOD

7.68e-0399763PS01187
DomainASX_HYDROXYL

EYS CRELD2 UMOD

7.89e-03100763PS00010
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ESRP2 PCSK5 SH3PXD2B RAPGEF6 PNPLA6 SCN5A SREBF1 MUS81 SENP2 LRRK1 DENND5A ELAC2 TRAPPC9

7.49e-071105761335748872
Pubmed

The PDZ domain of the guanine nucleotide exchange factor PDZGEF directs binding to phosphatidic acid during brush border formation.

RAPGEF6 RAPGEF2

4.71e-06276224858808
Pubmed

Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking.

RAPGEF6 RAPGEF2

4.71e-06276232600317
Pubmed

Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain.

RAPGEF6 RAPGEF2

1.41e-05376229747665
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

SH3PXD2B RAPGEF6 TTC28 DSP IKBKE RABEP1 CGN RAPGEF2 CDC25C TRAPPC9

1.79e-05861761036931259
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

SH3PXD2B RAPGEF6 GALK1 GTF3C1 TTC28 DSP RABEP1 CGN

2.69e-0554976838280479
Pubmed

Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47.

TCF3 SREBF1

2.82e-05476216055439
Pubmed

The helix-loop-helix factors Id3 and E47 are novel regulators of adiponectin.

TCF3 SREBF1

2.82e-05476218669923
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

RAPGEF6 TTC28 RABEP1 CGN RAPGEF2 CDC25C TRAPPC9

5.55e-0544676724255178
Pubmed

Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction.

RAPGEF2 RAPGEFL1

9.83e-05776210934204
Pubmed

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.

RAPGEF6 RAPGEF2

2.10e-041076223885123
Pubmed

Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models.

DSP SCN5A

2.56e-041176227766308
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

RAPGEF6 GTF3C1 KIF15 TTC28 DSP RABEP1

3.13e-0441876634709266
Pubmed

Crucial Role of Rapgef2 and Rapgef6, a Family of Guanine Nucleotide Exchange Factors for Rap1 Small GTPase, in Formation of Apical Surface Adherens Junctions and Neural Progenitor Development in the Mouse Cerebral Cortex.

RAPGEF6 RAPGEF2

3.62e-041376227390776
Pubmed

Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.

ERI1 EXOSC4

3.62e-041376218172165
Pubmed

USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling.

USP49 PHLPP2

3.62e-041376228363942
Pubmed

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.

KIF15 CRELD2 MUS81 ERI1

4.18e-0415976424927181
Pubmed

A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.

USP49 MED18

4.86e-041576214576168
Pubmed

Rap2A links intestinal cell polarity to brush border formation.

RAPGEF6 RAPGEF2

4.86e-041576222797597
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

PCSK5 RAPGEF6 GTF3C1 TTC28 SREBF1 EXOC3 DENND5A

5.53e-0465076738777146
Pubmed

Partial transcriptome of the developing pituitary gland.

ZHX1-C8orf76 C8orf76

5.54e-041676211161784
Pubmed

Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.

USP49 MED18

1.06e-032276212584197
Pubmed

Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development.

SALL3 WNT2B

1.16e-032376220159597
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

RAPGEF6 TTC28 RABEP1 MYPN

1.16e-0320976436779422
Pubmed

Genomic analysis of mouse retinal development.

ATXN7L3 TCF3 SALL3 KIF15 WNT2B CYGB KLHL18 PHLPP2

1.58e-03100676815226823
Pubmed

Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

MYO15B SANBR LRRK1

1.69e-0310776311347906
CytobandEnsembl 112 genes in cytogenetic band chr8q24

ZHX1-C8orf76 MROH5 C8orf76 EXOSC4 TRAPPC9

3.17e-04355765chr8q24
Cytoband8q24.3

MROH5 EXOSC4 TRAPPC9

8.96e-041137638q24.3
CytobandEnsembl 112 genes in cytogenetic band chr17q25

MYO15B GALK1 CYGB CARD14

1.72e-03307764chr17q25
Cytoband17q25

CYGB CARD14

1.93e-033976217q25
Cytoband15q26.3

CERS3 LRRK1

2.13e-034176215q26.3
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

USP49 ZHX1-C8orf76 PNPLA6 CYGB EXOSC4

1.28e-0517676576fdf211bce101e83a27d822cb399487bd107027
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

EYS ZPBP CGN ADAMTS20 SLC24A3

2.04e-05194765e5990880961d2469759ce4b3b20ae93ace3ebd1f
ToppCelldistal-1-Epithelial-Basal|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

EYS KHDC1L DSP CERS3 SLC24A3

2.20e-0519776525a2ccc98b973611de0d920b1b455d0b40f0d37f
ToppCelldistal-Epithelial-Basal-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

EYS KHDC1L DSP CERS3 RAPGEFL1

2.20e-0519776575b4292ce2ad7f9c8b6a4781e1cb71f5b18b74e3
ToppCellTransverse-T_cell-cycling_gd_T|Transverse / Region, Cell class and subclass

USP49 KIF15 SCN5A MUS81 CDC25C

2.25e-051987655131b0b7d6c4dd8872cef9f2e233f59f751b4690
ToppCellTransverse-(1)_T_cell-(18)_cycling_gd_T|Transverse / shred on region, Cell_type, and subtype

USP49 KIF15 SCN5A MUS81 CDC25C

2.25e-05198765396dddf7ebad41c3a91329b6a280623c0dfdcd2f
DrugAmidopyrine [58-15-1]; Down 200; 17.2uM; MCF7; HT_HG-U133A

ESRP2 MED18 TCF3 IKBKE THAP3 CARD14 PHLPP2

4.31e-061977672222_DN
DiseasePolyneuropathy

NMNAT2 PNPLA6

3.51e-054722C0152025
DiseaseYKL40 measurement, cerebrospinal fluid biomarker measurement

EYS CNTNAP5

5.84e-055722EFO_0004869, EFO_0006794
Diseaserestrictive cardiomyopathy (implicated_via_orthology)

MYPN MYH15

4.50e-0413722DOID:397 (implicated_via_orthology)
DiseaseBurkitt Leukemia

TCF3 SALL3

6.04e-0415722C4721444
DiseaseAfrican Burkitt's lymphoma

TCF3 SALL3

6.04e-0415722C0343640
Diseasekidney disease (biomarker_via_orthology)

SREBF1 CYGB

1.20e-0321722DOID:557 (biomarker_via_orthology)
Diseaseuromodulin measurement

UMOD B4GALNT2

1.84e-0326722EFO_0021778
DiseaseCalcium channel blocker use measurement

WNT2B DPY19L4 UMOD B4GALNT2

1.85e-03213724EFO_0009930
DiseaseBone Diseases, Developmental

PCSK5 SH3PXD2B

1.98e-0327722C0005941

Protein segments in the cluster

PeptideGeneStartEntry
QDGCELRINEKMHAG

ERI1

311

Q8IV48
LEQSENGACLHKRMG

B4GALNT2

441

Q8NHY0
MRLQNLRGGHICLHD

FTHL17

71

Q9BXU8
RGESKLHMCLDIGNG

AKIP1

121

Q9NQ31
LHMCLDIGNGQRKDR

AKIP1

126

Q9NQ31
HLEKCLGMGRNSSRI

ATXN7L3

101

Q14CW9
VQHKGMERGRLNCST

ADAMTS20

1531

P59510
EVHNAGNKLGRRCDM

RABEP1

521

Q15276
KLGEDMLCLLHGRNS

ITPRIP

261

Q8IWB1
NKHIEDGMGRNLADR

MFN1

446

Q8IWA4
MKRDVQEGQARCLAH

C8orf76

91

Q96K31
QEGQARCLAHLGRHM

C8orf76

96

Q96K31
ELCRHMVFQRLGQGD

PNPLA6

206

Q8IY17
HGDRKSCEMGLQLRQ

EXOSC4

91

Q9NPD3
HCAKRIVSGARGMNN

LYZL6

111

O75951
EDQLLFGCRLKGMHT

EYS

121

Q5T1H1
HAEGMRLKEAGNINR

KIF15

276

Q9NS87
MLALACQRGHLGVVK

LRRK1

156

Q38SD2
LRCVVAGMNHLRENG

IKBKE

116

Q14164
MRDKEAGLAQAHQGC

DCAF12L2

136

Q5VW00
EGLQLLRGMCVHATK

PCSK5

1151

Q92824
HNFKGLLDGMTCNLR

DCSTAMP

116

Q9H295
LMGQKGHALLIDCRS

GALK1

191

P51570
IHQCFERRTKGAGNM

SLC24A3

261

Q9HC58
PNGLDRGHRKRDAMC

CDC25C

131

P30307
PEMGDKNRHALVRNC

MED18

91

Q9BUE0
DQAPRGMAALCQHKL

MYO15B

601

Q96JP2
GMAALCQHKLLGALE

MYO15B

606

Q96JP2
EMDCLKNGLRAERHL

CERS3

361

Q8IU89
AGMLNKRCRHGAASL

KLHL18

461

O94889
AMEGRAKGELQVHCN

CARD14

686

Q9BXL6
PQLRKHACRVMGALN

CYGB

76

Q8WWM9
RRQIEHCEGRMTLKN

DSP

676

P15924
MHHRNDSQRLGKAGC

CXXC4

1

Q9H2H0
GCRVKDLLDIANGHM

DPY19L4

656

Q7Z388
GKFQMLVCLGARDHL

DENND5A

1216

Q6IQ26
QDSKCHARGLKMLER

KHDC1L

91

Q5JSQ8
GALLQAHRKLMDLEC

EXOC3

136

O60645
CHRCRGLVDKFNQGM

CRELD2

31

Q6UXH1
RRGCSTMGNLKQHLL

SALL3

1011

Q9BXA9
RLDVAKVCLGNMGHA

IFT140

816

Q96RY7
KVCLGNMGHARGARA

IFT140

821

Q96RY7
FLGCIRSLHLNGQKM

CNTNAP5

926

Q8WYK1
LQGRSRGLMIEACAH

NOXRED1

26

Q6NXP6
KGVGLLARAMVQNHC

MROH5

981

Q6ZUA9
SMGQKGHRICEILLQ

SENP2

496

Q9HC62
MNGHLRLLNIACAAK

RAPGEF6

511

Q8TEU7
DGAQKRRMLHCVQRA

ING1

206

Q9UK53
ARMNCERELHKLEGN

MYH15

1056

Q9Y2K3
LIGLQLFMGNLRHKC

SCN5A

266

Q14524
HRGKMETLEIDRGCL

TEKT2

176

Q9UIF3
CEELAQAALRRHKGM

ESRP2

411

Q9H6T0
GCKVRDHMVTLRDQG

SANBR

456

Q6NSI8
KLGDRRLLHDCQQML

SREBF1

1121

P36956
RELMLHARCCLNQKG

ATRAID

56

Q6UW56
NMKRLLDQGEDLRHG

CGN

426

Q9P2M7
MGGHLRLLNIACAAK

RAPGEF2

366

Q9Y4G8
NCGEGVQRLMQEHKL

ELAC2

86

Q9BQ52
HRLECGANDMKVSLG

UMOD

331

P07911
HGLAEMAGQRNKLCV

PHLPP2

786

Q6ZVD8
NEAFKELGRMCQLHL

TCF3

566

P15923
RLFQLKNDMGLECGH

SH3PXD2B

586

A1X283
MDRCKHVGRLRLAQD

USP49

1

Q70CQ1
HLGCRLASIEMKRDG

SMCO3

46

A2RU48
CHRVKMQRAGLQNEL

ZPBP

216

Q9BS86
GHAARCMQDLERAKQ

TTC28

441

Q96AY4
MKHLLCAGDKNGTRR

nan

71

Q5W150
RMGIQHLGNALLVCE

TOMM20L

91

Q6UXN7
CQGRMRKHVGDLCLQ

TRAPPC9

201

Q96Q05
RKHVGDLCLQAGMLQ

TRAPPC9

206

Q96Q05
RQCQMEPNSDGHDRK

TRMT10A

76

Q8TBZ6
MSSRLRACKGHQGLQ

THAP3

216

Q8WTV1
DCGKGYNRRLNLDMH

ZNF224

656

Q9NZL3
GRREEAALLMKQHGC

TRANK1

1916

O15050
EGLGRKQACLAMLLH

RAPGEFL1

211

Q9UHV5
HMILENKDGIQGSCR

GTF3C1

101

Q12789
IKRQHRAMGNECPAA

UBQLN3

91

Q9H347
GQARCLAHLGRHMEA

ZHX1-C8orf76

66

Q96EF9
KDARALMNLHNNRCG

WNT2B

211

Q93097
LQHFGDGLCRMLDER

MUS81

66

Q96NY9
SKRNEHCKMRREGDG

MYPN

986

Q86TC9
GKQGLVSSRHRLIMC

NMNAT2

56

Q9BZQ4