Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glycerol kinase activity	GK GK2	6.01e-05	3	90	2	GO:0004370
GeneOntologyMolecularFunction	calmodulin-dependent protein phosphatase activity	PPP3CA PPP3CC	1.99e-04	5	90	2	GO:0033192
GeneOntologyBiologicalProcess	process utilizing autophagic mechanism	ATG4A TEX264 PIK3CB AP5Z1 UBR4 WDR81 EXOC1 ATG9A WDFY3 HUWE1 LRBA TRIM13 WDFY4	3.67e-06	650	88	13	GO:0061919
GeneOntologyBiologicalProcess	autophagy	ATG4A TEX264 PIK3CB AP5Z1 UBR4 WDR81 EXOC1 ATG9A WDFY3 HUWE1 LRBA TRIM13 WDFY4	3.67e-06	650	88	13	GO:0006914
GeneOntologyBiologicalProcess	macroautophagy	ATG4A TEX264 AP5Z1 WDR81 EXOC1 ATG9A WDFY3 HUWE1 LRBA TRIM13	4.38e-06	374	88	10	GO:0016236
GeneOntologyBiologicalProcess	glycerol-3-phosphate biosynthetic process	GK GK2	5.38e-05	3	88	2	GO:0046167
GeneOntologyBiologicalProcess	aggrephagy	ATG4A WDR81 WDFY3	5.85e-05	18	88	3	GO:0035973
GeneOntologyBiologicalProcess	cellular catabolic process	ATG4A PHYH ABCA2 GLA TEX264 PIK3CB AP5Z1 UBR4 WDR81 EXOC1 ATG9A WDFY3 HUWE1 LRBA TRIM13 WDFY4	7.13e-05	1253	88	16	GO:0044248
GeneOntologyBiologicalProcess	glycerol metabolic process	GK GK2 SHPK	1.09e-04	22	88	3	GO:0006071
GeneOntologyBiologicalProcess	alditol metabolic process	GK GK2 SHPK	1.82e-04	26	88	3	GO:0019400
GeneOntologyCellularComponent	autophagosome membrane	TEX264 WDR81 ATG9A WDFY3	1.16e-04	57	92	4	GO:0000421
GeneOntologyCellularComponent	calcineurin complex	PPP3CA PPP3CC	2.84e-04	6	92	2	GO:0005955
GeneOntologyCellularComponent	sperm mitochondrial sheath	GK2 PPP3CC	3.97e-04	7	92	2	GO:0097226
Domain	BEACH_dom	WDR81 WDFY3 LRBA WDFY4	6.52e-08	9	91	4	IPR000409
Domain	BEACH	WDR81 WDFY3 LRBA WDFY4	6.52e-08	9	91	4	PS50197
Domain	Beach	WDR81 WDFY3 LRBA WDFY4	6.52e-08	9	91	4	PF02138
Domain	-	WDR81 WDFY3 LRBA WDFY4	6.52e-08	9	91	4	1.10.1540.10
Domain	Beach	WDR81 WDFY3 LRBA WDFY4	6.52e-08	9	91	4	SM01026
Domain	FGGY_KINASES_2	GK GK2 SHPK	1.11e-06	5	91	3	PS00445
Domain	FGGY_KINASES_1	GK GK2 SHPK	1.11e-06	5	91	3	PS00933
Domain	Carb_kinase_FGGY_N	GK GK2 SHPK	2.21e-06	6	91	3	IPR018484
Domain	Carb_kinase_FGGY	GK GK2 SHPK	3.86e-06	7	91	3	IPR000577
Domain	FGGY_N	GK GK2 SHPK	3.86e-06	7	91	3	PF00370
Domain	PH-BEACH_dom	WDFY3 LRBA WDFY4	6.16e-06	8	91	3	IPR023362
Domain	-	WDFY3 LRBA WDFY4	6.16e-06	8	91	3	2.30.29.40
Domain	PH_BEACH	WDFY3 LRBA WDFY4	6.16e-06	8	91	3	PS51783
Domain	ABC_A	ABCA2 ABCA4 ABCA6	2.38e-05	12	91	3	IPR026082
Domain	ARM-type_fold	PIK3CB UBR4 UTP20 WDFY3 HUWE1 LRBA WDFY4 ARMC1 MAP3K1	4.08e-05	339	91	9	IPR016024
Domain	Carb_kinase_FGGY_CS	GK GK2	7.02e-05	3	91	2	IPR018483
Domain	WD40_repeat_dom	EML5 UBR4 WDR81 WDR82 WDFY3 LRBA WDFY4 BRWD1	1.01e-04	297	91	8	IPR017986
Domain	Glycerol_kin	GK GK2	1.40e-04	4	91	2	IPR005999
Domain	Carb_kinase_FGGY_C	GK GK2	2.33e-04	5	91	2	IPR018485
Domain	DUF4704	WDFY3 LRBA	2.33e-04	5	91	2	IPR031570
Domain	DUF4704	WDFY3 LRBA	2.33e-04	5	91	2	PF15787
Domain	WD40	EML5 WDR81 WDR82 WDFY3 LRBA WDFY4 BRWD1	2.73e-04	259	91	7	PF00400
Domain	Calcineurin-like_PHP_ApaH	PPP3CA PPP3CC NT5E	3.36e-04	28	91	3	IPR004843
Domain	Metallophos	PPP3CA PPP3CC NT5E	3.36e-04	28	91	3	PF00149
Domain	WD40	EML5 WDR81 WDR82 WDFY3 LRBA WDFY4 BRWD1	3.36e-04	268	91	7	SM00320
Domain	FGGY_C	GK GK2	3.48e-04	6	91	2	PF02782
Domain	PH_BEACH	WDFY3 LRBA	3.48e-04	6	91	2	PF14844
Domain	ARM-like	AP5Z1 UTP20 WDFY3 HUWE1 LRBA WDFY4 ARMC1	3.51e-04	270	91	7	IPR011989
Domain	WD40_repeat	EML5 WDR81 WDR82 WDFY3 LRBA WDFY4 BRWD1	3.67e-04	272	91	7	IPR001680
Domain	Metallo-depent_PP-like	PPP3CA PPP3CC NT5E	4.13e-04	30	91	3	IPR029052
Domain	-	PPP3CA PPP3CC NT5E	4.13e-04	30	91	3	3.60.21.10
Domain	WD_REPEATS_1	EML5 WDR81 WDR82 WDFY3 LRBA WDFY4 BRWD1	4.19e-04	278	91	7	PS00678
Domain	WD_REPEATS_2	EML5 WDR81 WDR82 WDFY3 LRBA WDFY4 BRWD1	4.28e-04	279	91	7	PS50082
Domain	WD_REPEATS_REGION	EML5 WDR81 WDR82 WDFY3 LRBA WDFY4 BRWD1	4.28e-04	279	91	7	PS50294
Domain	-	AP5Z1 UTP20 WDFY3 LRBA WDFY4 ARMC1	7.58e-04	222	91	6	1.25.10.10
Domain	-	EML5 WDR81 WDR82 WDFY3 LRBA WDFY4 BRWD1	1.21e-03	333	91	7	2.130.10.10
Domain	WD40_repeat_CS	EML5 WDR82 WDFY3 WDFY4 BRWD1	1.24e-03	164	91	5	IPR019775
Domain	WD40/YVTN_repeat-like_dom	EML5 WDR81 WDR82 WDFY3 LRBA WDFY4 BRWD1	1.25e-03	335	91	7	IPR015943
Domain	Quinoprot_gluc/sorb_DH	EML5 HHIPL2	1.50e-03	12	91	2	IPR011041
Domain	ABC_tran	ABCA2 ABCA4 ABCA6	1.65e-03	48	91	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCA2 ABCA4 ABCA6	1.65e-03	48	91	3	PS50893
Domain	ABC_TRANSPORTER_1	ABCA2 ABCA4 ABCA6	1.75e-03	49	91	3	PS00211
Domain	Ser/Thr-sp_prot-phosphatase	PPP3CA PPP3CC	1.77e-03	13	91	2	IPR006186
Domain	SER_THR_PHOSPHATASE	PPP3CA PPP3CC	1.77e-03	13	91	2	PS00125
Domain	PP2Ac	PPP3CA PPP3CC	1.77e-03	13	91	2	SM00156
Domain	ABC_transporter-like	ABCA2 ABCA4 ABCA6	1.86e-03	50	91	3	IPR003439
Domain	PUA-like_domain	LONRF1 UHRF2	3.80e-03	19	91	2	IPR015947
Pathway	BIOCARTA_VIP_PATHWAY	PPP3CA PPP3CC MAP3K1 CHUK	6.90e-06	25	71	4	MM1441
Pathway	BIOCARTA_VIP_PATHWAY	PPP3CA PPP3CC MAP3K1 CHUK	8.12e-06	26	71	4	M17941
Pathway	BIOCARTA_MEF2D_PATHWAY	PPP3CA PPP3CC CABIN1	6.54e-05	16	71	3	MM1483
Pathway	BIOCARTA_MEF2D_PATHWAY	PPP3CA PPP3CC CABIN1	9.46e-05	18	71	3	M5290
Pathway	WP_CALCIUM_MEDIATED_TCELL_APOPTOSIS_INVOLVED_IN_INCLUSION_BODY_MYOSITIS	PPP3CA PPP3CC CABIN1	1.31e-04	20	71	3	M48330
Pathway	WP_VITAMIN_D_IN_INFLAMMATORY_DISEASES	PPP3CA MAP3K1 CHUK	1.76e-04	22	71	3	M39773
Pathway	REACTOME_DARPP_32_EVENTS	PDE4A PPP3CA PPP3CC	2.30e-04	24	71	3	M751
Pathway	BIOCARTA_HDAC_PATHWAY	PPP3CA PPP3CC CABIN1	2.60e-04	25	71	3	M1547
Pathway	PID_BCR_5PATHWAY	PPP3CA PPP3CC MAP3K1 CHUK	2.81e-04	63	71	4	M10
Pathway	BIOCARTA_HDAC_PATHWAY	PPP3CA PPP3CC CABIN1	2.93e-04	26	71	3	MM1371
Pathway	PID_TRAIL_PATHWAY	PIK3CB MAP3K1 CHUK	3.66e-04	28	71	3	M79
Pathway	BIOCARTA_BCR_PATHWAY	PPP3CA PPP3CC MAP3K1	5.47e-04	32	71	3	MM1355
Pathway	KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY	PPP3CA PPP3CC PIK3CB CHUK	5.48e-04	75	71	4	M5436
Pathway	BIOCARTA_BCR_PATHWAY	PPP3CA PPP3CC MAP3K1	5.99e-04	33	71	3	M9494
Pathway	BIOCARTA_FMLP_PATHWAY	PPP3CA PPP3CC MAP3K1	6.55e-04	34	71	3	M10287
Pathway	BIOCARTA_FMLP_PATHWAY	PPP3CA PPP3CC MAP3K1	6.55e-04	34	71	3	MM1399
Pubmed	Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells.	PPP3CA PPP3CC CABIN1	7.39e-08	4	93	3	11714752
Pubmed	Glycerol kinase 2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis.	GK GK2	7.07e-06	2	93	2	30662012
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FASN ABCA2 PDE4A SZT2 LONRF1 GRK6 UBR4 COBL ATG9A WDFY3 HUWE1 LRBA CABIN1	7.74e-06	1105	93	13	35748872
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	FASN GLA UBR4 POLR1C WDR82 HUWE1 PFKP THOC2 NUP205	1.36e-05	534	93	9	35032548
Pubmed	The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT.	PPP3CA CABIN1	2.12e-05	3	93	2	15671033
Pubmed	Glycerol kinase-like proteins cooperate with Pld6 in regulating sperm mitochondrial sheath formation and male fertility.	GK GK2	2.12e-05	3	93	2	28852571
Pubmed	Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods.	PPP3CA PPP3CC	2.12e-05	3	93	2	2162844
Pubmed	Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes.	PPP3CA CABIN1	2.12e-05	3	93	2	9655484
Pubmed	The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding.	PPP3CA PPP3CC	2.12e-05	3	93	2	19154138
Pubmed	CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosis.	NT5E PIK3CB	2.12e-05	3	93	2	30971294
Pubmed	Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit.	PPP3CA PPP3CC	2.12e-05	3	93	2	1659808
Pubmed	Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.	PPP3CA PPP3CC CHUK	3.15e-05	23	93	3	20379146
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ABCA2 PPP3CA LONRF1 UBR4 POLR1C TFIP11 EXOC1 WDFY3 HUWE1 LRBA CABIN1 CHUK BRWD1	3.76e-05	1285	93	13	35914814
Pubmed	Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.	MAP3K1 CHUK	4.23e-05	4	93	2	9819420
Pubmed	Molecular and phylogenetic analysis of calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit genes.	PPP3CA PPP3CC	4.23e-05	4	93	2	1318721
Pubmed	Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency disorders.	NLRP12 LRBA	4.23e-05	4	93	2	26122175
Pubmed	TRIM26 promotes non-small cell lung cancer survival by inducing PBX1 degradation.	UBR4 HUWE1	4.23e-05	4	93	2	37324936
Pubmed	ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport.	ABCA2 ABCA6	4.23e-05	4	93	2	10639163
Pubmed	Calcineurin: form and function.	PPP3CA PPP3CC	7.04e-05	5	93	2	11015619
Pubmed	The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons.	GK GK2	7.04e-05	5	93	2	7987308
Pubmed	G protein-coupled receptor kinase 2-mediated phosphorylation of downstream regulatory element antagonist modulator regulates membrane trafficking of Kv4.2 potassium channel.	PPP3CA GRK6	7.04e-05	5	93	2	17102134
Pubmed	Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults.	PPP3CA PPP3CC	7.04e-05	5	93	2	20593291
Pubmed	Elevated expression of calcineurin subunits during active mineralization of developing mouse molar teeth.	PPP3CA PPP3CC	7.04e-05	5	93	2	22984995
Pubmed	Ca2+/calmodulin-dependent protein phosphatase calcineurin mediates the expression of iNOS through IKK and NF-kappaB activity in LPS-stimulated mouse peritoneal macrophages and RAW 264.7 cells.	PPP3CA CHUK	7.04e-05	5	93	2	14741691
Pubmed	Are calcineurin genes associated with endurance phenotype traits?	PPP3CA PPP3CC	7.04e-05	5	93	2	20107831
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	MYH7 FASN GK AP5Z1 UBR4 UTP20 HUWE1 CABIN1 CHUK NUP205	1.00e-04	857	93	10	25609649
Pubmed	Mammalian brain phosphoproteins as substrates for calcineurin.	PPP3CA PPP3CC	1.05e-04	6	93	2	6330098
Pubmed	Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.	PPP3CA PPP3CC	1.05e-04	6	93	2	10195903
Pubmed	ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system.	ATG4A LRBA	1.05e-04	6	93	2	33773106
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	FASN UBR4 POLR1C UTP20 WDR82 HUWE1 LRBA PFKP NUP205	1.15e-04	704	93	9	29955894
Pubmed	The protein serine/threonine phosphatases PP2A, PP1 and calcineurin: A triple threat in the regulation of the neuronal cytoskeleton.	PPP3CA PPP3CC	1.47e-04	7	93	2	28126489
Pubmed	Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase.	MAP3K1 CHUK	1.47e-04	7	93	2	16286467
Pubmed	Retrotransposition of glycerol kinase-related genes from the X chromosome to autosomes: functional and evolutionary aspects.	GK GK2	1.47e-04	7	93	2	10444329
Pubmed	Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity.	PPP3CA PPP3CC	1.47e-04	7	93	2	8631904
Pubmed	Low affinity Ca2+-binding sites of calcineurin B mediate conformational changes in calcineurin A.	PPP3CA PPP3CC	1.47e-04	7	93	2	11123943
Pubmed	DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.	WDR81 WDR82 WDFY3 BRWD1	1.49e-04	99	93	4	34161765
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	RAVER2 HUWE1 WDFY4 NIN	1.60e-04	101	93	4	10997877
Pubmed	A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.	PHYH NT5E HELZ HUWE1 PFKP FAM111B BRWD1	1.62e-04	431	93	7	33660365
Pubmed	Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1.	AP5Z1 UBR4	1.96e-04	8	93	2	37871017
Pubmed	AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling.	PPP3CA PPP3CC	1.96e-04	8	93	2	17640527
Pubmed	MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta.	MAP3K1 CHUK	1.96e-04	8	93	2	9689078
Pubmed	Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study.	UTP20 WDFY4	1.96e-04	8	93	2	17903303
Pubmed	FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.	LONRF1 SYT9 NUP205	1.97e-04	42	93	3	29348145
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	FASN SZT2 PIK3CB UBR4 ACSM1 CDK5RAP1 HELZ WDR82 ATG9A PFKP METTL23 NUP205	2.18e-04	1327	93	12	32694731
Pubmed	Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling.	PPP3CA PPP3CC	2.52e-04	9	93	2	22343722
Pubmed	A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase.	MAP3K1 CHUK	2.52e-04	9	93	2	12624112
Pubmed	SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice.	PPP3CA PPP3CC	2.52e-04	9	93	2	34446558
Pubmed	Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study.	MYH7 GLA	2.52e-04	9	93	2	16754800
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FASN UBR4 POLR1C UTP20 WDR82 TFIP11 EXOC1 FASTKD2 WDFY3 HUWE1 PFKP NUP205	2.60e-04	1353	93	12	29467282
Pubmed	Defining the membrane proteome of NK cells.	FASN ABCA2 GRK6 UBR4 HELZ EXOC1 ATG9A HUWE1 LRBA PFKP NUP205	2.88e-04	1168	93	11	19946888
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR11L1 OR13C3 OR4C46 OR8B12 OR4L1 OR8B8	3.12e-04	340	93	6	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR11L1 OR13C3 OR4C46 OR8B12 OR4L1 OR8B8	3.12e-04	340	93	6	11802173
Pubmed	HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα.	HUWE1 CHUK	3.14e-04	10	93	2	30217973
Pubmed	Characterization of a cluster comprising approximately 100 odorant receptor genes in mouse.	OR8B12 OR8B8	3.14e-04	10	93	2	11130974
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR11L1 OR13C3 OR4C46 OR8B12 OR4L1 OR8B8	3.27e-04	343	93	6	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR11L1 OR13C3 OR4C46 OR8B12 OR4L1 OR8B8	3.42e-04	346	93	6	14611657
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FASN UBR4 HELZ UTP20 HUWE1 PFKP THOC2 NUP205	3.71e-04	653	93	8	22586326
Pubmed	Use of Chuk as an internal standard suitable for quantitative RT-PCR in mouse preimplantation embryos.	CHUK NLRP5	3.83e-04	11	93	2	16984773
Pubmed	Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers.	MYH7 PPP3CA	3.83e-04	11	93	2	16024798
Pubmed	Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential.	MYH7 ZBTB16	3.83e-04	11	93	2	26979619
Pubmed	Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain.	MAP3K1 CHUK	3.83e-04	11	93	2	11057907
Pubmed	Intrinsically Disordered Protein TEX264 Mediates ER-phagy.	ATG4A TEX264 WDR82 LRBA	4.33e-04	131	93	4	31006538
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	FASN UBR4 POLR1C COBL EXOC1 HUWE1 PFKP TRIM13 THOC2 CABIN1 CHUK NUP205	4.56e-04	1440	93	12	30833792
Pubmed	A reassessment of the inhibitory capacity of human FKBP38 on calcineurin.	PPP3CA PPP3CC	4.59e-04	12	93	2	15757646
Pubmed	Centrosome linker protein C-Nap1 maintains stem cells in mouse testes.	ZBTB16 NIN	4.59e-04	12	93	2	35599622
Pubmed	Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.	UBR4 PFKP UHRF2	5.13e-04	58	93	3	31067491
Pubmed	Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system.	ZBTB16 ASB16 ANAPC5 PCGF5	5.27e-04	138	93	4	28786561
Pubmed	Insulin receptor substrate-4 interacts with ubiquitin-specific protease 18 to activate the Jak/STAT signaling pathway.	FASN HUWE1	5.41e-04	13	93	2	29285303
Pubmed	UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.	UBR4 HUWE1 BRWD1	6.24e-04	62	93	3	18775313
Pubmed	Differential signaling mechanism for HIV-1 Nef-mediated production of IL-6 and IL-8 in human astrocytes.	PIK3CB CHUK	6.30e-04	14	93	2	26075907
Pubmed	The genetics of NOD-like receptors in Crohn's disease.	NLRP12 NLRP5	6.30e-04	14	93	2	20403135
Pubmed	NALPs: a novel protein family involved in inflammation.	NLRP12 NLRP5	6.30e-04	14	93	2	12563287
Pubmed	Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions.	PPP3CA PPP3CC	6.30e-04	14	93	2	28826478
Pubmed	Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure.	MYH7 PPP3CA	6.30e-04	14	93	2	24161931
Pubmed	The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.	UBR4 HUWE1	6.30e-04	14	93	2	27626314
Pubmed	Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients.	PPP3CA PPP3CC	7.26e-04	15	93	2	21047202
Pubmed	Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.	MAP3K1 CHUK	7.26e-04	15	93	2	18635759
Pubmed	Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome.	HUWE1 PFKP NUP205	7.83e-04	67	93	3	29357390
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	FASN UBR4 POLR1C HELZ WDR82 TFIP11 FASTKD2 HUWE1 LRBA THOC2 NUP205	7.88e-04	1318	93	11	30463901
Pubmed	Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure.	PPP3CA PPP3CC	9.37e-04	17	93	2	24086760
Pubmed	Fibroproliferative response to urothelial failure obliterates the ureter lumen in a mouse model of prenatal congenital obstructive nephropathy.	UPK1A EXOC1	9.37e-04	17	93	2	27511831
Pubmed	Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.	UBR4 ANAPC5	9.37e-04	17	93	2	29033132
Pubmed	IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism.	MYH7 CHUK	9.37e-04	17	93	2	22351927
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	FASN GLA UBR4 POLR1C UTP20 HUWE1 PFKP ANAPC5 NUP205	9.53e-04	942	93	9	31073040
Pubmed	Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.	PPP3CA AP5Z1 ATG9A TICAM2 CHUK	9.98e-04	283	93	5	21903422
Pubmed	MD-2: the Toll 'gatekeeper' in endotoxin signalling.	TICAM2 MAP3K1 CHUK	1.05e-03	74	93	3	15276183
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	FASN HELZ UTP20 TFIP11 HUWE1 PFKP THOC2 ANAPC5	1.12e-03	774	93	8	15302935
Pubmed	Autoregulation of the 26S proteasome by in situ ubiquitination.	UBR4 HUWE1	1.17e-03	19	93	2	24743594
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	RAVER2 CDK5RAP1 UTP20 LRBA PFKP	1.25e-03	298	93	5	30737378
Pubmed	LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.	FASN HUWE1 PFKP	1.26e-03	79	93	3	26446488
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	NDST3 LYPD4 PRSS57 ADAMTS4 TEX264 HHIPL2 CPXM1 WDR82 CPED1	1.30e-03	985	93	9	12975309
Pubmed	Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism.	MYH7 PPP3CA	1.30e-03	20	93	2	26299309
Pubmed	Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition.	NAT2 ABCA2	1.30e-03	20	93	2	21072184
Pubmed	Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules.	MYH7 PPP3CA	1.30e-03	20	93	2	21421818
Pubmed	Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation.	PPP3CA PPP3CC	1.44e-03	21	93	2	31696965
Pubmed	Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells.	FASN CHUK	1.44e-03	21	93	2	21093383
Pubmed	Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model.	ABCA2 ABCA6	1.44e-03	21	93	2	23137377
Pubmed	Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.	FASN UBR4 HUWE1	1.51e-03	84	93	3	29563501
Pubmed	Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.	TESK2 PFKP	1.58e-03	22	93	2	26631746
Pubmed	Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum.	ATG9A HUWE1	1.58e-03	22	93	2	37225996
GeneFamily	WD repeat domain containing\|BEACH domain containing	WDR81 WDFY3 LRBA WDFY4	2.27e-08	9	68	4	1230
GeneFamily	ATP binding cassette subfamily A	ABCA2 ABCA4 ABCA6	1.80e-05	14	68	3	805
GeneFamily	WD repeat domain containing	EML5 WDR81 WDR82 WDFY3 LRBA WDFY4 BRWD1	5.65e-05	262	68	7	362
GeneFamily	Glycerol kinases	GK GK2	2.07e-04	6	68	2	568
GeneFamily	Protein phosphatase catalytic subunits\|EF-hand domain containing	PPP3CA PPP3CC	1.06e-03	13	68	2	693
GeneFamily	NLR family	NLRP12 NLRP5	3.95e-03	25	68	2	666
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP12 NLRP5	3.95e-03	25	68	2	994
Drug	LX201	PPP3CA PPP3CC CABIN1	2.63e-07	4	93	3	CID006440291
Drug	suppressor of FK506 1	PPP3CA PPP3CC CABIN1	2.63e-07	4	93	3	CID000419462
Drug	botrydial	PPP3CA PPP3CC CABIN1	6.56e-07	5	93	3	CID000185781
Drug	2,2,2-trifluoroethyl phosphate	PPP3CA PPP3CC CABIN1	2.28e-06	7	93	3	CID000151044
Drug	1-benzothiophene-2-carboxamide	PPP3CA PPP3CC CABIN1	2.28e-06	7	93	3	CID000237073
Drug	AC1L1D8L	ZBTB16 PPP3CA PPP3CC CABIN1 MAP3K1	1.07e-05	71	93	5	CID000002241
Drug	endothall thioanhydride	PPP3CA PPP3CC CABIN1	1.41e-05	12	93	3	CID000176108
Drug	1-norokadaone	PPP3CA PPP3CC CABIN1	1.41e-05	12	93	3	CID003309928
Drug	INCA-6	PPP3CA PPP3CC CABIN1	1.41e-05	12	93	3	CID000230748
Drug	4-nitro-phen-yl	PPP3CA PPP3CC GLA NT5E CABIN1	3.99e-05	93	93	5	CID000119211
Drug	DAP000594	PPP3CA PPP3CC GLA CABIN1	4.07e-05	47	93	4	CID006447131
Drug	4-(fluoromethyl)phenyl phosphate	PPP3CA PPP3CC CABIN1	5.15e-05	18	93	3	CID000192584
Disease	very long-chain acyl-CoA synthetase measurement	NLRP12 PFKP	9.20e-06	2	90	2	EFO_0802211
Disease	glycerol kinase deficiency (implicated_via_orthology)	GK GK2	2.75e-05	3	90	2	DOID:0060363 (implicated_via_orthology)
Disease	Chediak-Higashi syndrome (implicated_via_orthology)	WDFY3 WDFY4	5.50e-05	4	90	2	DOID:2935 (implicated_via_orthology)
Disease	retinoic acid receptor responder protein 3 measurement	NLRP12 PFKP	5.50e-05	4	90	2	EFO_0802005
Disease	drebrin-like protein measurement	NLRP12 GRK6	9.15e-05	5	90	2	EFO_0020333
Disease	stathmin-2 measurement	NLRP12 ATG9A	1.37e-04	6	90	2	EFO_0802087
Disease	tumor necrosis factor receptor superfamily member 16 measurement	NLRP12 GRK6	3.27e-04	9	90	2	EFO_0802168
Disease	intercellular adhesion molecule 5 measurement	PDE4A ABCA6	7.02e-04	13	90	2	EFO_0008164
Disease	N-acetylglycine measurement	OR8B12 UHRF2	8.17e-04	14	90	2	EFO_0021002
Disease	cardiomyopathy (implicated_via_orthology)	MYH7 PPP3CA PPP3CC	1.35e-03	71	90	3	DOID:0050700 (implicated_via_orthology)
Disease	Infiltrating duct carcinoma of female breast	TESK2 GRK6	1.86e-03	21	90	2	C3165106
Disease	aspartate measurement	NDST3 GRK6	2.43e-03	24	90	2	EFO_0010462
Disease	systemic mastocytosis	ABCA2 MSH5	2.64e-03	25	90	2	MONDO_0016586
Disease	breast cancer, lung cancer	MSH5 MAP3K1	2.64e-03	25	90	2	MONDO_0007254, MONDO_0008903
Disease	Hypertrophic obstructive cardiomyopathy	MYH7 FASN	2.64e-03	25	90	2	C4551472
Disease	taurine measurement	NLRP12 GRK6	2.85e-03	26	90	2	EFO_0010536

Protein segments in the cluster

Peptide	Gene	Start	Entry
QHLCLVFEPLSMNLR	PRPF4B	761	Q13523
MLACLQRTQNAPGQH	FAM222A	1	Q5U5X8
HCLQSPQRMNILNLD	ATG4A	301	Q8WYN0
VMCQLGLHQKANRLP	CPED1	171	A4D0V7
VRQSLGMCPQHNILF	ABCA4	1001	P78363
LPCFLARVLMHIFQN	GPR31	236	O00270
LHCFPILMNIISNGL	ABCA6	971	Q8N139
ALCMVNQPRQLQHLA	ASB16	401	Q96NS5
QDQGCLPGLILFMDH	ARMC1	36	Q9NVT9
LLLMQFLCHEFLRGN	CPXM1	371	Q96SM3
MQLRNPELHLGCALA	GLA	1	P06280
LHQLLQPMAGCARVA	AP5Z1	536	O43299
NAHPLCMVIGLIFLQ	CYB561	51	P49447
HKNIMVLPRQTCGLF	NDST3	466	O95803
AMLQVLLQPQLCGRA	RAVER2	351	Q9HCJ3
NNLVNHYMCDILPLL	OR8B8	171	Q15620
NPLVMHQLRCNGVLE	MYH7	686	P12883
LMELQGHIGRFQRQC	NUP205	1701	Q92621
NRCAMLFRQLHQELP	ANAPC5	731	Q9UJX4
CGNQVHETNPLEMLR	PCGF5	56	Q86SE9
HQLFCMVQLEPGQSE	PARP15	491	Q460N3
RECFSNHPLGMNQLQ	LETMD1	236	Q6P1Q0
KQPRCFVLMDHILNL	CHUK	296	O15111
GCMLQIRNVHFLPDG	LONRF1	621	Q17RB8
VIDHFMCDLNPLLNL	OR4C46	171	A6NHA9
VLTMNLPFCGHNVIN	OR4L1	161	Q8NH43
SLNGNHAVRLPLMEC	PFKP	346	Q01813
QVLRNMVHCADLSNP	PDE4A	581	P27815
GMPLLKQLCDHVLLN	LRBA	561	P50851
HGMQFLHNLILNRNP	LRRC37B	651	Q96QE4
MGPQHLRLVQLFCLL	LYPD4	1	Q6UWN0
FLLMGCAREHNQLLA	LYPD4	186	Q6UWN0
CQMNNLPHLQVVGLT	METTL23	66	Q86XA0
RLPHCSLQRLMLNQC	NLRP5	976	P59047
RNQINHFFCDLPPLM	OR11L1	171	Q8NGX0
LQFQLNRLPLCEMHY	HELZ	591	P42694
HGFLPVLVRNCIQAM	HUWE1	356	Q7Z6Z7
NLVNHFMCDILPLLE	OR8B12	171	Q8NGG6
MCLGNLIPRHQELFN	CDKL2	216	Q92772
RFNIMCNHLRFNLPQ	GAL3ST2	111	Q9H3Q3
CNHLRFNLPQVQKVM	GAL3ST2	116	Q9H3Q3
CLHMDQLQDFNIPQA	ADAMTS4	506	O75173
RTMPCGQLLHFLQRN	C2orf92	176	A0A1B0GVN3
QQLQHMPAQGLFCER	CABIN1	1561	Q9Y6J0
MNRDCGIPLRHLQVD	GK2	411	Q14410
PDQHMVFCPEQLLRV	ATG9A	426	Q7Z3C6
MDLLVELCLQNHLNP	COBL	86	O75128
AMNRDCGIPLSHLQV	GK	416	P32189
EIRKNLGMCPQHNVL	ABCA2	1061	Q9BZC7
LGMCPQHNVLFDRLT	ABCA2	1066	Q9BZC7
DHLLQICQRIGPMLD	BRWD1	76	Q9NSI6
QIRAVPFENLNMHCG	NAT2	31	P11245
LLQCMNVALRPGHDL	EXOC1	311	Q9NV70
QERNKPFLIMQGHCE	EML5	311	Q05BV3
HILRQCENPNMECIL	FAM111B	171	Q6SJ93
NRHLGMVAQDPQGCL	HHIPL2	191	Q6UWX4
RQMLQFPHISQCEEL	GRK6	31	P43250
CLEVLDLFLNQPHMV	FASN	2091	P49327
PLAALMNQQFLCVHG	PPP3CA	186	Q08209
LLAMRLPFCGNNIIN	OR13C3	191	Q8NGS6
CVLMLLEHGADQNIP	POTEC	221	B2RU33
MEHISRNNGCLVVLP	PHYH	196	O14832
VRIQNGRHPLMELCA	MSH5	556	O43196
LNHPNIIRMLGATCE	MAP3K1	1301	Q13233
MPGARDALCHQALQL	SYT9	1	Q86SS6
PLLFLACHLFVINMN	TAS2R43	136	P59537
FHFDLMGLLPQCQQL	SZT2	991	Q5T011
QGLLHENCGMFFIPL	UTP20	2316	O75691
MKQLHRCPDLSDFQQ	NIN	1686	Q8N4C6
LDNIHGCPLRIMINI	FASTKD2	371	Q9NYY8
PMTHANDICLLRLNG	PRSS57	116	Q6UWY2
ANHVQRLRQMLACPP	SLC9B2	66	Q86UD5
ALCRGIVQNLHSMLP	SHPK	401	Q9UHJ6
IFAEMPCGRQHLQNL	TICAM2	111	Q86XR7
QLRPGQEIDLLMHCV	POLR1C	201	O15160
NCVMNRALPHFILVE	PIK3CB	271	P42338
GNLICDAMINNNLRH	NT5E	361	P21589
CGLQQGDHLALMLPR	ACSM1	106	Q08AH1
MHPLQCVLQVQRSLG	CDK5RAP1	1	Q96SZ6
RPLIIRMNCNFQKHA	PGBD2	246	Q6P3X8
CRHDLGQNYIMIPNE	UHRF2	771	Q96PU4
LLNQQFLCVHGGMSP	PPP3CC	186	P48454
HDLALPLCLLMAQQR	THOC2	736	Q8NI27
FFNEHMRKLCNQVPI	UNC80	591	Q8N2C7
HPTGLLCKANQMRLA	ZBTB16	16	Q05516
GHLGQPLNIFCLTDM	TRIM13	96	O60858
CSPQDNALGLMHLRR	WDFY3	16	Q8IZQ1
LRSPNCQGLMHLQGK	WDR82	136	Q6UXN9
NAMPVFLLRNCAGHL	WDFY4	1326	Q6ZS81
DQIHFMCPLARQGDF	TEX264	176	Q9Y6I9
NFIPLNEEGCRLGHM	UPK1A	196	O00322
NRLSHPNILRFMGVC	TESK2	106	Q96S53
HQLMGHRPQLENLLC	UBR4	3751	Q5T4S7
LNPHLRQLMVNLDQG	ZNHIT3	106	Q15649
LGMCLGELVINPHQQ	TFIP11	616	Q9UBB9
VPLQCLLHRDMQALG	WDR81	761	Q562E7
CEGLRHPQCRLQMIQ	NLRP12	791	P59046