Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	1-phosphatidylinositol-4-phosphate 5-kinase activity	PIP5K1A PIP5K1B PIP5K1C	1.02e-06	9	47	3	GO:0016308
GeneOntologyMolecularFunction	1-phosphatidylinositol-3-phosphate 5-kinase activity	PIP5K1A PIP5K1B	1.62e-05	3	47	2	GO:0000285
GeneOntologyMolecularFunction	1-phosphatidylinositol-5-kinase activity	PIP5K1A PIP5K1B	1.62e-05	3	47	2	GO:0052810
GeneOntologyMolecularFunction	phosphatidylinositol kinase activity	PIP5K1A PIP5K1B PIP5K1C	3.06e-05	26	47	3	GO:0052742
GeneOntologyMolecularFunction	olfactory receptor activity	OR1G1 OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	6.20e-05	431	47	7	GO:0004984
GeneOntologyMolecularFunction	lipid kinase activity	PIP5K1A PIP5K1B PIP5K1C	1.22e-04	41	47	3	GO:0001727
GeneOntologyMolecularFunction	protein kinase activator activity	DAB2IP ADIPOQ NRG3 IQGAP1	4.14e-04	149	47	4	GO:0030295
GeneOntologyMolecularFunction	kinase activator activity	DAB2IP ADIPOQ NRG3 IQGAP1	5.29e-04	159	47	4	GO:0019209
GeneOntologyMolecularFunction	protein serine/threonine kinase activator activity	DAB2IP ADIPOQ IQGAP1	8.22e-04	78	47	3	GO:0043539
GeneOntologyMolecularFunction	protein phosphatase binding	DAB2IP CACNA1B SH3RF2 IQGAP1	1.49e-03	210	47	4	GO:0019903
GeneOntologyMolecularFunction	sialic acid binding	ADIPOQ SIGLEC9	1.57e-03	25	47	2	GO:0033691
GeneOntologyBiologicalProcess	mitotic actomyosin contractile ring assembly	IQGAP3 IQGAP1	1.52e-05	3	47	2	GO:1903475
GeneOntologyBiologicalProcess	mitotic actomyosin contractile ring assembly actin filament organization	IQGAP3 IQGAP1	1.52e-05	3	47	2	GO:1903479
GeneOntologyBiologicalProcess	assembly of actomyosin apparatus involved in mitotic cytokinesis	IQGAP3 IQGAP1	1.52e-05	3	47	2	GO:1902407
GeneOntologyBiologicalProcess	actomyosin contractile ring assembly actin filament organization	IQGAP3 IQGAP1	3.04e-05	4	47	2	GO:2000689
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR1G1 OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	5.14e-05	432	47	7	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR1G1 OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	8.16e-05	465	47	7	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR1G1 OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	1.06e-04	485	47	7	GO:0050907
GeneOntologyBiologicalProcess	regulation of glycogen (starch) synthase activity	ADIPOQ GSK3B	1.41e-04	8	47	2	GO:2000465
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR1G1 OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	1.71e-04	524	47	7	GO:0009593
GeneOntologyBiologicalProcess	actomyosin contractile ring assembly	IQGAP3 IQGAP1	1.81e-04	9	47	2	GO:0000915
GeneOntologyBiologicalProcess	assembly of actomyosin apparatus involved in cytokinesis	IQGAP3 IQGAP1	1.81e-04	9	47	2	GO:0000912
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR1G1 OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	2.23e-04	547	47	7	GO:0007606
GeneOntologyBiologicalProcess	glomerular epithelial cell development	ADIPOQ IQGAP1	2.26e-04	10	47	2	GO:0072310
GeneOntologyBiologicalProcess	actomyosin contractile ring organization	IQGAP3 IQGAP1	2.26e-04	10	47	2	GO:0044837
GeneOntologyBiologicalProcess	podocyte development	ADIPOQ IQGAP1	2.26e-04	10	47	2	GO:0072015
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR1G1 OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	3.24e-04	582	47	7	GO:0050906
GeneOntologyBiologicalProcess	negative regulation of dendrite morphogenesis	GSK3B TRPC6	3.31e-04	12	47	2	GO:0050774
GeneOntologyBiologicalProcess	regulation of dendrite development	DAB2IP GSK3B TRPC6 IQGAP1	3.76e-04	150	47	4	GO:0050773
GeneOntologyBiologicalProcess	regulation of neuron migration	DAB2IP NRG3 GSK3B	3.82e-04	62	47	3	GO:2001222
GeneOntologyBiologicalProcess	negative regulation of neuron migration	NRG3 GSK3B	3.90e-04	13	47	2	GO:2001223
GeneOntologyBiologicalProcess	phosphatidylinositol phosphate biosynthetic process	PIP5K1A PIP5K1B PIP5K1C	4.59e-04	66	47	3	GO:0046854
GeneOntologyCellularComponent	filtration diaphragm	TRPC6 IQGAP1	2.69e-04	11	47	2	GO:0036056
GeneOntologyCellularComponent	slit diaphragm	TRPC6 IQGAP1	2.69e-04	11	47	2	GO:0036057
GeneOntologyCellularComponent	uropod	PIP5K1B PIP5K1C	4.43e-04	14	47	2	GO:0001931
GeneOntologyCellularComponent	cell trailing edge	PIP5K1B PIP5K1C	5.10e-04	15	47	2	GO:0031254
Domain	PInositol-4-P-5-kinase	PIP5K1A PIP5K1B PIP5K1C	5.19e-07	7	47	3	IPR023610
Domain	PIPK	PIP5K1A PIP5K1B PIP5K1C	8.29e-07	8	47	3	PS51455
Domain	PIPKc	PIP5K1A PIP5K1B PIP5K1C	8.29e-07	8	47	3	SM00330
Domain	-	PIP5K1A PIP5K1B PIP5K1C	8.29e-07	8	47	3	3.30.800.10
Domain	PInositol-4-P-5-kinase_N	PIP5K1A PIP5K1B PIP5K1C	8.29e-07	8	47	3	IPR027484
Domain	PInositol-4-P-5-kinase_C	PIP5K1A PIP5K1B PIP5K1C	8.29e-07	8	47	3	IPR027483
Domain	-	PIP5K1A PIP5K1B PIP5K1C	8.29e-07	8	47	3	3.30.810.10
Domain	PInositol-4-P-5-kinase_core	PIP5K1A PIP5K1B PIP5K1C	8.29e-07	8	47	3	IPR002498
Domain	PIP5K	PIP5K1A PIP5K1B PIP5K1C	8.29e-07	8	47	3	PF01504
Domain	RasGAP	DAB2IP IQGAP3 IQGAP1	5.33e-06	14	47	3	SM00323
Domain	RasGAP_CS	DAB2IP IQGAP3 IQGAP1	5.33e-06	14	47	3	IPR023152
Domain	RAS_GTPASE_ACTIV_2	DAB2IP IQGAP3 IQGAP1	6.65e-06	15	47	3	PS50018
Domain	RasGAP	DAB2IP IQGAP3 IQGAP1	6.65e-06	15	47	3	PF00616
Domain	RAS_GTPASE_ACTIV_1	DAB2IP IQGAP3 IQGAP1	6.65e-06	15	47	3	PS00509
Domain	-	DAB2IP IQGAP3 IQGAP1	8.17e-06	16	47	3	1.10.506.10
Domain	RasGAP_dom	DAB2IP IQGAP3 IQGAP1	1.19e-05	18	47	3	IPR001936
Domain	RasGAP_C	IQGAP3 IQGAP1	1.86e-05	3	47	2	IPR000593
Domain	RasGAP_C	IQGAP3 IQGAP1	1.86e-05	3	47	2	PF03836
Domain	Olfact_rcpt	OR1G1 OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	5.27e-05	393	47	7	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR1G1 OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	1.34e-03	670	47	7	IPR017452
Domain	Rho_GTPase_activation_prot	DAB2IP IQGAP3 IQGAP1	1.41e-03	88	47	3	IPR008936
Domain	7tm_1	OR1G1 OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	1.42e-03	677	47	7	PF00001
Domain	IQ_motif_EF-hand-BS	MYO15B IQGAP3 IQGAP1	1.51e-03	90	47	3	IPR000048
Domain	G_PROTEIN_RECEP_F1_1	OR1G1 OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	1.52e-03	685	47	7	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR1G1 OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	1.60e-03	691	47	7	PS50262
Domain	GPCR_Rhodpsn	OR1G1 OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	1.61e-03	692	47	7	IPR000276
Domain	IQ	MYO15B IQGAP3 IQGAP1	1.65e-03	93	47	3	PS50096
Domain	-	IFNK IL22	7.03e-03	50	47	2	1.20.1250.10
Domain	4_helix_cytokine_core	IFNK IL22	7.31e-03	51	47	2	IPR012351
Domain	CH	IQGAP3 IQGAP1	1.17e-02	65	47	2	SM00033
Domain	CH	IQGAP3 IQGAP1	1.34e-02	70	47	2	PF00307
Domain	IQ	IQGAP3 IQGAP1	1.38e-02	71	47	2	PF00612
Pathway	PID_RAC1_PATHWAY	PIP5K1A PIP5K1B PIP5K1C IQGAP3 IQGAP1	2.71e-07	54	37	5	M278
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR1G1 OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	5.81e-05	389	37	7	M14091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR1G1 OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	9.00e-05	417	37	7	M4072
Pathway	WP_B_CELL_RECEPTOR_SIGNALING	PIP5K1A PIP5K1B PIP5K1C GSK3B	1.17e-04	97	37	4	M39323
Pathway	REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK	PIP5K1A PIP5K1B NRG3 PIP5K1C	2.11e-04	113	37	4	MM14783
Pathway	PID_RHOA_PATHWAY	PIP5K1A PIP5K1B PIP5K1C	2.19e-04	45	37	3	M12
Pathway	KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	PIP5K1A PIP5K1B PIP5K1C IQGAP3 IQGAP1	2.21e-04	213	37	5	M18306
Pathway	WP_PHOSPHATIDYL_INOSITOL_PHOSPHATE_PATHWAY	PIP5K1A PIP5K1B PIP5K1C	2.34e-04	46	37	3	M48317
Pathway	REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK	PIP5K1A PIP5K1B NRG3 PIP5K1C	2.49e-04	118	37	4	M713
Pathway	WP_PHOSPHOINOSITIDES_METABOLISM	PIP5K1A PIP5K1B PIP5K1C	2.82e-04	49	37	3	M40046
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	PIP5K1A PIP5K1B PIP5K1C	3.00e-04	50	37	3	MM14641
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	PIP5K1A PIP5K1B PIP5K1C	3.56e-04	53	37	3	M662
Pathway	KEGG_INOSITOL_PHOSPHATE_METABOLISM	PIP5K1A PIP5K1B PIP5K1C	3.76e-04	54	37	3	M3896
Pathway	WP_REGULATION_OF_ACTIN_CYTOSKELETON	PIP5K1A PIP5K1B PIP5K1C IQGAP1	6.19e-04	150	37	4	M39520
Pathway	WP_REGULATION_OF_ACTIN_CYTOSKELETON	PIP5K1A PIP5K1B PIP5K1C IQGAP1	6.51e-04	152	37	4	MM15834
Pathway	PID_CDC42_PATHWAY	IQGAP3 GSK3B IQGAP1	8.07e-04	70	37	3	M81
Pathway	KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	PIP5K1A PIP5K1B PIP5K1C	1.03e-03	76	37	3	M9052
Pathway	REACTOME_PI_METABOLISM	PIP5K1A PIP5K1B PIP5K1C	1.07e-03	77	37	3	MM14590
Pathway	REACTOME_SENSORY_PERCEPTION	OR1G1 OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	1.16e-03	636	37	7	M41834
Pathway	BIOCARTA_RHO_PATHWAY	PIP5K1A PIP5K1B	1.24e-03	20	37	2	MM1476
Pathway	PID_WNT_CANONICAL_PATHWAY	PIP5K1B GSK3B	1.24e-03	20	37	2	M90
Pathway	REACTOME_INTRACELLULAR_SIGNALING_BY_SECOND_MESSENGERS	PIP5K1A PIP5K1B NRG3 PIP5K1C GSK3B	1.27e-03	313	37	5	M27867
Pathway	BIOCARTA_RHO_PATHWAY	PIP5K1A PIP5K1B	1.36e-03	21	37	2	M1001
Pathway	REACTOME_PI_METABOLISM	PIP5K1A PIP5K1B PIP5K1C	1.37e-03	84	37	3	M676
Pathway	KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS	PIP5K1A PIP5K1B PIP5K1C	2.01e-03	96	37	3	M16121
Pubmed	Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42.	PIP5K1A PIP5K1B PIP5K1C	2.31e-09	3	47	3	14681219
Pubmed	PIP5KIβ selectively modulates apical endocytosis in polarized renal epithelial cells.	PIP5K1A PIP5K1B PIP5K1C	2.31e-09	3	47	3	23342003
Pubmed	Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activator.	PIP5K1A PIP5K1B PIP5K1C	2.31e-09	3	47	3	22942276
Pubmed	Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes.	PIP5K1A PIP5K1B PIP5K1C	9.24e-09	4	47	3	18188447
Pubmed	Identification and characterization of a phosphoinositide phosphate kinase homolog.	PIP5K1A PIP5K1B PIP5K1C	9.24e-09	4	47	3	14701839
Pubmed	Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family.	PIP5K1A PIP5K1B PIP5K1C	9.24e-09	4	47	3	9535851
Pubmed	The lipid kinase PIP5K1C regulates pain signaling and sensitization.	PIP5K1A PIP5K1B PIP5K1C	2.31e-08	5	47	3	24853942
Pubmed	Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1.	PIP5K1A PIP5K1B PIP5K1C	4.61e-08	6	47	3	14614850
Pubmed	Smurf1 regulates lung cancer cell growth and migration through interaction with and ubiquitination of PIPKIγ.	PIP5K1A PIP5K1B PIP5K1C	4.61e-08	6	47	3	28581524
Pubmed	Rac controls PIP5K localisation and PtdIns(4,5)P₂ synthesis, which modulates vinculin localisation and neurite dynamics.	PIP5K1A PIP5K1B PIP5K1C	4.61e-08	6	47	3	20841379
Pubmed	Localization of mRNAs for phosphatidylinositol phosphate kinases in the mouse brain during development.	PIP5K1A PIP5K1B PIP5K1C	8.06e-08	7	47	3	15018809
Pubmed	Btk-dependent regulation of phosphoinositide synthesis.	PIP5K1A PIP5K1B PIP5K1C	1.29e-07	8	47	3	15046600
Pubmed	Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain.	PIP5K1A PIP5K1B PIP5K1C	1.29e-07	8	47	3	20622009
Pubmed	Comparative phenotypic analysis of the two major splice isoforms of phosphatidylinositol phosphate kinase type Iγ in vivo.	PIP5K1A PIP5K1B PIP5K1C	1.93e-07	9	47	3	22976293
Pubmed	Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens.	PIP5K1A STIP1 RNPEP GSK3B IQGAP1	1.46e-06	143	47	5	30397336
Pubmed	PI4P5-kinase Ialpha is required for efficient HIV-1 entry and infection of T cells.	PIP5K1A PIP5K1B	1.79e-06	2	47	2	18981107
Pubmed	The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells.	PIP5K1B PIP5K1C	1.79e-06	2	47	2	19549683
Pubmed	PI5KI-dependent signals are critical regulators of the cytolytic secretory pathway.	PIP5K1A PIP5K1C	1.79e-06	2	47	2	18073347
Pubmed	Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling.	PIP5K1A PIP5K1C	1.79e-06	2	47	2	12682053
Pubmed	A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis.	PIP5K1A PIP5K1B	1.79e-06	2	47	2	16979564
Pubmed	Type I Phosphatidylinositol-4-Phosphate 5-Kinases α and γ Play a Key Role in Targeting HIV-1 Pr55Gag to the Plasma Membrane.	PIP5K1A PIP5K1C	1.79e-06	2	47	2	32376619
Pubmed	Essential and unique roles of PIP5K-gamma and -alpha in Fcgamma receptor-mediated phagocytosis.	PIP5K1A PIP5K1C	1.79e-06	2	47	2	19153220
Pubmed	Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly.	PIP5K1A PIP5K1B	1.79e-06	2	47	2	10679324
Pubmed	Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.	PIP5K1A PIP5K1B	1.79e-06	2	47	2	18772378
Pubmed	Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase.	PIP5K1A PIP5K1B	1.79e-06	2	47	2	8798574
Pubmed	Phosphatidylinositol-4-phosphate-5-kinase alpha deficiency alters dynamics of glucose-stimulated insulin release to improve glucohomeostasis and decrease obesity in mice.	PIP5K1A PIP5K1B	1.79e-06	2	47	2	21270258
Pubmed	A central kinase domain of type I phosphatidylinositol phosphate kinases is sufficient to prime exocytosis: isoform specificity and its underlying mechanism.	PIP5K1A PIP5K1B	1.79e-06	2	47	2	15728183
Pubmed	Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes.	PIP5K1A PIP5K1B	1.79e-06	2	47	2	10187762
Pubmed	Type I phosphotidylinosotol 4-phosphate 5-kinase γ regulates osteoclasts in a bifunctional manner.	PIP5K1A PIP5K1C	1.79e-06	2	47	2	23300084
Pubmed	Nuclear-localized costimulatory molecule 4-1BBL promotes colon cancer cell proliferation and migration by regulating nuclear Gsk3β, and is linked to the poor outcomes associated with colon cancer.	TNFRSF9 GSK3B	1.79e-06	2	47	2	31992123
Pubmed	CAT-2 amplifies the agonist-evoked force of airway smooth muscle by enhancing spermine-mediated phosphatidylinositol-(4)-phosphate-5-kinase-gamma activity.	SLC7A2 PIP5K1C	1.79e-06	2	47	2	17644755
Pubmed	PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions.	PIP5K1A PIP5K1C	1.79e-06	2	47	2	19889969
Pubmed	Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family.	PIP5K1A PIP5K1B	1.79e-06	2	47	2	8955136
Pubmed	Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.	OR6C65 OR6C1 OR6C74	4.59e-06	24	47	3	24152035
Pubmed	PI3K-resistant GSK3 controls adiponectin formation and protects from metabolic syndrome.	ADIPOQ GSK3B	5.36e-06	3	47	2	27140617
Pubmed	The biology of IQGAP proteins: beyond the cytoskeleton.	IQGAP3 IQGAP1	5.36e-06	3	47	2	25722290
Pubmed	IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration.	PIP5K1C IQGAP1	5.36e-06	3	47	2	23982733
Pubmed	CLIC1 recruits PIP5K1A/C to induce cell-matrix adhesions for tumor metastasis.	PIP5K1A PIP5K1C	5.36e-06	3	47	2	33079727
Pubmed	Adiponectin stimulates proliferation of adult hippocampal neural stem/progenitor cells through activation of p38 mitogen-activated protein kinase (p38MAPK)/glycogen synthase kinase 3β (GSK-3β)/β-catenin signaling cascade.	ADIPOQ GSK3B	5.36e-06	3	47	2	22039048
Pubmed	IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.	IQGAP3 IQGAP1	5.36e-06	3	47	2	22493426
Pubmed	Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis.	PIP5K1A PIP5K1B	5.36e-06	3	47	2	22321832
Pubmed	Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis.	IQGAP3 IQGAP1	5.36e-06	3	47	2	25229330
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	6.40e-06	340	47	6	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	6.40e-06	340	47	6	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	6.73e-06	343	47	6	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR6C65 OR5M3 OR7G2 OR5AS1 OR6C1 OR6C74	7.07e-06	346	47	6	14611657
Pubmed	Valosin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1)-interacting protein.	IQGAP3 IQGAP1	1.07e-05	4	47	2	28970065
Pubmed	Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis.	DAB2IP GSK3B	1.07e-05	4	47	2	20080667
Pubmed	Complementation of growth factor receptor-dependent mitogenic signaling by a truncated type I phosphatidylinositol 4-phosphate 5-kinase.	PIP5K1A PIP5K1B	1.07e-05	4	47	2	9372970
Pubmed	Effect of adiponectin on cardiac β-catenin signaling pathway under angiotensin II infusion.	ADIPOQ GSK3B	1.78e-05	5	47	2	24462873
Pubmed	Phosphatidylinositol 4,5-bisphosphate regulates adipocyte actin dynamics and GLUT4 vesicle recycling.	PIP5K1A PIP5K1C	2.67e-05	6	47	2	15123724
Pubmed	C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances.	STIP1 GSK3B	4.98e-05	8	47	2	22824801
Pubmed	P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.	CACNA1B GSK3B	6.40e-05	9	47	2	19555761
Pubmed	Genome-wide association study of retinopathy in individuals without diabetes.	TENM4 NRG3	7.99e-05	10	47	2	23393555
Pubmed	The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking.	VPS52 IQGAP3 IQGAP1 DNAH1	9.75e-05	177	47	4	26485645
Pubmed	Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex.	GSK3B IQGAP1	9.75e-05	11	47	2	21709260
Pubmed	IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade.	IQGAP3 IQGAP1	1.17e-04	12	47	2	18604197
Pubmed	Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.	PIP5K1A IQGAP3 IQGAP1	2.42e-04	89	47	3	27034005
Pubmed	The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2.	IQGAP3 IQGAP1	2.70e-04	18	47	2	19961560
Pubmed	Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins.	STIP1 IQGAP1	3.34e-04	20	47	2	22504172
Pubmed	Adiponectin enhances mouse fetal fat deposition.	ADIPOQ GSK3B	3.34e-04	20	47	2	22872236
Pubmed	Dysfunctional ryanodine receptor and cardiac hypertrophy: role of signaling molecules.	GSK3B TRPC6	3.34e-04	20	47	2	21421818
Pubmed	Signal peptide prediction based on analysis of experimentally verified cleavage sites.	IFNK TNFRSF9 ADIPOQ IL22	4.48e-04	264	47	4	15340161
Pubmed	Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues.	TNFRSF9 ADIPOQ	4.84e-04	24	47	2	28324027
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DAB2IP STIP1 GSK3B IQGAP1	5.66e-04	281	47	4	28706196
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	IDH3B IQGAP3 IQGAP1	5.81e-04	120	47	3	27320910
Pubmed	Embryonic Steroids Control Developmental Programming of Energy Balance.	CACNA1B GSK3B	6.14e-04	27	47	2	34599818
Pubmed	The human olfactory receptor gene family.	OR1G1 OR5M3 OR7G2 OR5AS1 OR6C74	8.00e-04	541	47	5	14983052
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	STIP1 VPS52 IDH3B CLPX WDR33 NFU1 ARID2 GSK3B	8.10e-04	1496	47	8	32877691
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	PIP5K1A VPS52 IDH3B RNPEP IQGAP1	9.34e-04	560	47	5	35241646
Pubmed	Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.	ADIPOQ FMOD RNPEP	1.03e-03	146	47	3	27068509
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	TENM4 CEMIP2 DNAH1	1.17e-03	153	47	3	10718198
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1B TRPC6	1.22e-03	38	47	2	30786075
Pubmed	Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin.	GSK3B IQGAP1	1.28e-03	39	47	2	16510873
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	STIP1 IDH3B WDR33 NFU1 GSK3B IQGAP1 DNAH1	1.34e-03	1247	47	7	27684187
Interaction	PIP5KL1 interactions	PIP5K1A PIP5K1B PIP5K1C	3.38e-07	7	44	3	int:PIP5KL1
Interaction	PIP5K1B interactions	PIP5K1A PIP5K1B PIP5K1C	2.73e-06	13	44	3	int:PIP5K1B
Interaction	PIP5K1C interactions	PIP5K1A PIP5K1B PIP5K1C IQGAP1	4.23e-06	50	44	4	int:PIP5K1C
Cytoband	12q13.2	OR6C65 OR6C1 OR6C74	2.54e-05	55	47	3	12q13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr3q13	CFAP91 ARGFX GSK3B UPK1B	7.92e-05	221	47	4	chr3q13
Cytoband	1q32	FMOD RNPEP	1.17e-03	49	47	2	1q32
Cytoband	1q21.3	PIP5K1A IQGAP3	6.46e-03	117	47	2	1q21.3
GeneFamily	Olfactory receptors, family 6	OR6C65 OR6C1 OR6C74	7.34e-05	51	29	3	153
Disease	retinopathy	TENM4 NRG3	2.91e-04	17	44	2	EFO_0003839
Disease	type 2 diabetes mellitus (biomarker_via_orthology)	ADIPOQ GSK3B TRPC6	1.38e-03	147	44	3	DOID:9352 (biomarker_via_orthology)
Disease	lysine measurement	SLC7A2 ADIPOQ	1.40e-03	37	44	2	EFO_0005002
Disease	Arthritis, Adjuvant-Induced	ADIPOQ GSK3B	1.64e-03	40	44	2	C0003865
Disease	Arthritis, Collagen-Induced	ADIPOQ GSK3B	1.64e-03	40	44	2	C0971858
Disease	Arthritis, Experimental	ADIPOQ GSK3B	1.64e-03	40	44	2	C0993582
Disease	Kidney Neoplasm	TNFRSF9 KYAT1	1.64e-03	40	44	2	C0022665
Disease	Malignant neoplasm of kidney	TNFRSF9 KYAT1	2.07e-03	45	44	2	C0740457
Disease	Prostatic Neoplasms	DAB2IP ETV3 VPS52 ARID2 GSK3B	2.16e-03	616	44	5	C0033578
Disease	Malignant neoplasm of prostate	DAB2IP ETV3 VPS52 ARID2 GSK3B	2.16e-03	616	44	5	C0376358
Disease	major depressive episode	TENM4 CEMIP2	2.25e-03	47	44	2	EFO_0007634
Disease	multiple sclerosis (is_marker_for)	CACNA1B ADIPOQ	2.44e-03	49	44	2	DOID:2377 (is_marker_for)
Disease	Manic Disorder	TENM4 GSK3B	5.06e-03	71	44	2	C0024713
Disease	Bipolar Disorder	CACNA1B TENM4 NRG3 GSK3B	5.49e-03	477	44	4	C0005586

Protein segments in the cluster

Peptide	Gene	Start	Entry
NKFFFQMCQPIPSYL	RNPEP	216	Q9H4A4
PRNAVIPQYQALFSM	CLPX	521	O76031
PNMPIRFTKIFYNQQ	ADIPOQ	126	Q15848
NFNKLVMPNYPFINI	ETV3	116	P41162
QPDPFINRNYSNMKV	ARGFX	11	A6NJG6
RRAIPLPIQMYYQQQ	ARID2	601	Q68CP9
RQPQNQQKVAFMVPF	SLC7A2	546	P52569
MALYNPIPVKQNCFT	CACNA1B	56	Q00975
LPFFQQMPFNVVYAV	CFAP91	151	Q7Z4T9
TNPTYLAKLIFQMPQ	IQGAP1	981	P46940
PMMNPFIYSLRNQQV	OR6C1	281	Q96RD1
PMLNPFIYTLRNQQV	OR6C65	281	A6NJZ3
INMQLPSRETNPYFN	NRG3	566	P56975
QLLAPLSFQNPVYQM	DAB2IP	821	Q5VWQ8
PFVPSRMKYVYFQNN	FMOD	101	Q06828
MNNSFIYIKIPQVPL	KIAA0100	2111	Q14667
MYQRQQLPLPYEQLK	MAD2L1BP	81	Q15013
VRYMFIQTQDTPNPN	NFU1	56	Q9UMS0
PPGMRQQVFQFFSKV	FHIP2B	101	Q86V87
YMNLNQNPRTLLPKF	PIP5K1B	156	O14986
LIKVSPQLNNPMYFF	OR5M3	46	Q8NGP4
YYMNLNQNPRTLLPK	PIP5K1A	211	Q99755
QPIYLAKLIFQMPQN	IQGAP3	966	Q86VI3
VFPMFNPIIYSFRNK	OR5AS1	281	Q8N127
PCVLYFQVLMKNPTQ	PCDHB12	101	Q9Y5F1
PMLNPFIYTLRNKQV	OR6C74	281	A6NCV1
VTPMLNPFIYSLRNQ	OR1G1	281	P47890
SFQQKRNYFQRMGQP	MYO15B	966	Q96JP2
FPLQAYEPKMQVPFQ	DNAH1	166	Q9P2D7
QLVQNPYQFDVLVMP	IDH3B	256	O43837
PNPYRQAIMSFKNTQ	DYM	301	Q7RTS9
FELPQEFLQYTQPMK	IFNK	66	Q9P0W0
IREMNPNYTEFKFPQ	GSK3B	281	P49841
NQKAAFPQYQPVVML	CEMIP2	1026	Q9UHN6
ERKFMNPFNMPNLYQ	STIP1	121	P31948
FPQMVNPFIYSLRNK	OR7G2	281	Q8NG99
YMNLNQNPRTLLPKF	PIP5K1C	206	O60331
QPSSYFVQFPQAMQR	KYAT1	301	Q16773
NVSYPPQNLTMTVFQ	SIGLEC9	231	Q9Y336
NFQQPYITNRTFMLA	IL22	46	Q9GZX6
IYSFRKPMTNYQIPQ	VPS52	246	Q8N1B4
VEKQMYFPLQNYPVN	TERB2	156	Q8NHR7
LYIFKQPFMRPVQTT	TNFRSF9	221	Q07011
PFNLYMFKNNNPISN	TENM4	2446	Q6N022
FLKQMLERYQNNSPP	UPK1B	121	O75841
SPTMVLRPQQFQFYQ	SH3RF2	541	Q8TEC5
NSFNNPPRQYQKIMK	TRPC6	846	Q9Y210
FYKRPDFAQQQAMQQ	WDR33	26	Q9C0J8