Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncadherin binding

DIAPH3 PLEC

2.78e-0333952GO:0045296
GeneOntologyMolecularFunctionactin binding

DIAPH3 PLEC

5.47e-0347952GO:0003779
GeneOntologyMolecularFunctioncell adhesion molecule binding

DIAPH3 PLEC

8.46e-0359952GO:0050839
GeneOntologyBiologicalProcesscellular response to acid chemical

GRIN2D PLEC

7.20e-0417752GO:0071229
GeneOntologyBiologicalProcesscytokinesis

DIAPH3 PLEC

9.55e-0420452GO:0000910
GeneOntologyBiologicalProcessresponse to acid chemical

GRIN2D PLEC

1.19e-0322852GO:0001101
GeneOntologyBiologicalProcesssensory perception of mechanical stimulus

DIAPH3 GRIN2D

1.30e-0323852GO:0050954
GeneOntologyBiologicalProcessresponse to mechanical stimulus

GRIN2D PLEC

1.39e-0324752GO:0009612
GeneOntologyBiologicalProcessskin development

PLEC AHDC1

3.15e-0337352GO:0043588
GeneOntologyBiologicalProcessmembraneless organelle assembly

DIAPH3 PLEC

5.05e-0347552GO:0140694
GeneOntologyBiologicalProcessactin filament organization

DIAPH3 PLEC

5.78e-0350952GO:0007015
GeneOntologyCellularComponentcluster of actin-based cell projections

DIAPH3 PLEC

1.11e-0322352GO:0098862
MousePhenoskin detachment

PLEC AHDC1

6.14e-07452MP:0009827
MousePhenodermal-epidermal separation

PLEC AHDC1

3.68e-06952MP:0011160
MousePhenoabnormal epidermal-dermal junction morphology

PLEC AHDC1

6.75e-061252MP:0011159
MousePhenoabnormal skin appearance

DIAPH3 PLEC AHDC1

3.66e-0447353MP:0009931
MousePhenoabnormal cellular respiration

MRPS12 PLEC

1.13e-0315152MP:0010954
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MRPS12 GRIN2D PLEC AHDC1

4.94e-0611055435748872
CytobandEnsembl 112 genes in cytogenetic band chr19q13

MRPS12 GRIN2D

6.39e-03119252chr19q13
CoexpressionCROMER_METASTASIS_DN

MRPS12 PLEC

8.47e-057752M8417
CoexpressionFERRANDO_T_ALL_WITH_MLL_ENL_FUSION_UP

MRPS12 PLEC

1.13e-048952M6434
CoexpressionGSE2770_UNTREATED_VS_ACT_CD4_TCELL_2H_UP

PLEC AHDC1

5.59e-0419852M6025
CoexpressionGSE2128_C57BL6_VS_NOD_THYMOCYTE_UP

DIAPH3 AHDC1

5.65e-0419952M6183
CoexpressionGSE19825_NAIVE_VS_DAY3_EFF_CD8_TCELL_DN

MRPS12 PLEC

5.65e-0419952M4307
CoexpressionGSE14308_TH2_VS_TH1_UP

DIAPH3 GRIN2D

5.65e-0419952M3359
CoexpressionGSE21360_PRIMARY_VS_TERTIARY_MEMORY_CD8_TCELL_UP

MRPS12 PLEC

5.71e-0420052M7640
CoexpressionGSE3720_VD1_VS_VD2_GAMMADELTA_TCELL_WITH_LPS_STIM_DN

DIAPH3 AHDC1

5.71e-0420052M6354
CoexpressionGSE22886_NAIVE_CD4_TCELL_VS_48H_ACT_TH2_UP

PLEC AHDC1

5.71e-0420052M4528
CoexpressionBROWNE_HCMV_INFECTION_4HR_DN

PLEC AHDC1

9.03e-0425252M789
CoexpressionZHONG_PFC_C1_MICROGLIA

MRPS12 DIAPH3

9.39e-0425752M39103
ComputationalSpinal cord (neuro-development) genes.

PLEC AHDC1

3.28e-0336032MODULE_12
ComputationalOvary genes.

PLEC AHDC1

3.43e-0336832MODULE_1
ComputationalDRG (dorsal root ganglia) genes.

PLEC AHDC1

3.73e-0338432MODULE_2
ComputationalTrachea genes.

PLEC AHDC1

4.35e-0341532MODULE_6
Drugpenicillin

MRPS12 PLEC

5.91e-055652CID000002349
Drugphenazine

MRPS12 PLEC

1.71e-049552CID000004757
DrugPenicillins

MRPS12 PLEC

1.89e-0410052CID009548591
Drugpotassium cyanide

MRPS12 GRIN2D

2.68e-0411952CID000009032
Drugdiphenyl

GRIN2D PLEC

3.30e-0413252CID000007095
Drugtoluene

MRPS12 GRIN2D

5.79e-0417552CID000001140
Drugstrychnine HCl

GRIN2D AHDC1

6.19e-0418152CID000005304
Drug17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A_EA

MRPS12 PLEC

6.26e-0418252947_DN
DrugPuromycin dihydrochloride [58-58-2]; Down 200; 7.4uM; PC3; HT_HG-U133A

MRPS12 PLEC

6.46e-04185526711_DN
Drugtroglitazone; Up 200; 10uM; MCF7; HT_HG-U133A_EA

MRPS12 AHDC1

6.60e-04187521070_UP
DrugICI 182,780; Down 200; 0.01uM; MCF7; HT_HG-U133A

MRPS12 AHDC1

6.60e-04187526955_DN
Druggeldanamycin; Down 200; 1uM; HL60; HT_HG-U133A

MRPS12 PLEC

6.67e-04188526187_DN
DrugLY 294002; Down 200; 10uM; MCF7; HT_HG-U133A

MRPS12 AHDC1

6.67e-04188525224_DN
Druggenistein; Down 200; 10uM; HL60; HT_HG-U133A

MRPS12 PLEC

6.67e-04188521176_DN
Druglomustine; Down 200; 100uM; PC3; HT_HG-U133A

MRPS12 PLEC

6.67e-04188527050_DN
DrugLorglumide sodium salt [97964-56-2]; Down 200; 8.4uM; MCF7; HT_HG-U133A

MRPS12 PLEC

6.74e-04189525254_DN
DrugAG-012559 [369370-06-9]; Down 200; 10uM; PC3; HT_HG-U133A

MRPS12 PLEC

6.74e-04189526920_DN
Drug17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A

MRPS12 PLEC

6.81e-04190525223_DN
DrugAmbroxol hydrochloride [23828-92-4]; Down 200; 9.6uM; PC3; HT_HG-U133A

MRPS12 PLEC

6.81e-04190526719_DN
DrugPaclitaxel [33069-62-4]; Down 200; 4.6uM; PC3; HT_HG-U133A

MRPS12 PLEC

6.89e-04191526720_DN
DrugDorzolamide hydrochloride [130693-82-2]; Down 200; 11uM; HL60; HT_HG-U133A

MRPS12 PLEC

6.89e-04191526142_DN
DrugNitrofural [59-87-0]; Down 200; 20.2uM; PC3; HT_HG-U133A

MRPS12 PLEC

6.89e-04191526721_DN
Drug17-AAG; Down 200; 1uM; HL60; HT_HG-U133A

MRPS12 PLEC

6.89e-04191526184_DN
Drugradicicol, diheterospora chlamydosporia; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

MRPS12 PLEC

6.89e-04191521057_DN
DrugDenatonium benzoate [3734-33-6]; Down 200; 9uM; HL60; HT_HG-U133A

PLEC AHDC1

6.89e-04191523123_DN
DrugFusaric acid [536-69-6]; Down 200; 22.4uM; MCF7; HT_HG-U133A

MRPS12 PLEC

6.96e-04192523245_DN
DrugGossypol [303-45-7]; Down 200; 7.8uM; HL60; HT_HG-U133A

MRPS12 PLEC

7.03e-04193522202_DN
DrugMS-275; Down 200; 10uM; PC3; HT_HG-U133A

MRPS12 PLEC

7.03e-04193527084_DN
DrugDiprophylline [479-18-5]; Down 200; 15.8uM; PC3; HT_HG-U133A

MRPS12 PLEC

7.03e-04193521811_DN
Drugradicicol, diheterospora chlamydosporia; Down 200; 0.1uM; HL60; HT_HG-U133A

MRPS12 AHDC1

7.10e-04194526178_DN
DrugCapsaicin [404-86-4]; Down 200; 13uM; PC3; HT_HG-U133A

MRPS12 PLEC

7.10e-04194524612_DN
DrugLY 294002; Down 200; 10uM; MCF7; HT_HG-U133A

MRPS12 AHDC1

7.10e-04194525599_DN
DrugICI182,780; Down 200; 1uM; PC3; HT_HG-U133A

MRPS12 PLEC

7.10e-04194526918_DN
DrugCinchonine [118-10-5]; Down 200; 13.6uM; MCF7; HT_HG-U133A

MRPS12 PLEC

7.10e-04194524107_DN
DrugKhellin [82-02-0]; Up 200; 15.4uM; MCF7; HT_HG-U133A

PLEC AHDC1

7.10e-04194524987_UP
DrugAcetohexamide [968-81-0]; Down 200; 12.4uM; MCF7; HT_HG-U133A

PLEC AHDC1

7.10e-04194521707_DN
DrugST021200; Down 200; 10uM; PC3; HT_HG-U133A

MRPS12 PLEC

7.18e-04195527493_DN
DrugPropylthiouracil [51-52-5]; Down 200; 23.4uM; MCF7; HT_HG-U133A

MRPS12 AHDC1

7.18e-04195524157_DN
DrugGabazine [105538-73-6]; Down 200; 10.8uM; MCF7; HT_HG-U133A

MRPS12 PLEC

7.18e-04195524820_DN
DrugMolindone hydrochloride [15622-65-8]; Down 200; 12.8uM; MCF7; HT_HG-U133A

PLEC AHDC1

7.18e-04195524784_DN
Drugfluphenazine dihydrochloride; Down 200; 10uM; HL60; HT_HG-U133A

MRPS12 AHDC1

7.25e-04196522697_DN
DrugDiphenidol hydrochloride [3254-89-5]; Down 200; 11.6uM; HL60; HT_HG-U133A

MRPS12 AHDC1

7.25e-04196522374_DN
DrugFluvoxamine maleate [61718-82-9]; Down 200; 9.2uM; MCF7; HT_HG-U133A

PLEC AHDC1

7.25e-04196527333_DN
DrugCarisoprodol [78-44-4]; Down 200; 15.4uM; MCF7; HT_HG-U133A

PLEC AHDC1

7.25e-04196523251_DN
DrugFlupentixol dihydrochloride cis-(Z) [2413-38-9]; Up 200; 7.8uM; MCF7; HT_HG-U133A

MRPS12 PLEC

7.25e-04196525307_UP
DrugTolazoline hydrochloride [59-97-2]; Down 200; 20.4uM; MCF7; HT_HG-U133A

MRPS12 PLEC

7.25e-04196524844_DN
Drugprochlorperazine dimaleate salt; Down 200; 10uM; HL60; HT_HG-U133A

MRPS12 PLEC

7.25e-04196521156_DN
DrugZardaverine [101975-10-4]; Down 200; 15uM; MCF7; HT_HG-U133A

PLEC AHDC1

7.25e-04196524793_DN
Drug(-)-Quinpirole hydrochloride [85760-74-3]; Up 200; 15.6uM; MCF7; HT_HG-U133A

MRPS12 PLEC

7.25e-04196523539_UP
DrugEthoxyquin [91-53-2]; Down 200; 18.4uM; HL60; HT_HG-U133A

MRPS12 PLEC

7.32e-04197522559_DN
DrugMinaprine dihydrochloride [25953-17-7]; Down 200; 10.8uM; MCF7; HT_HG-U133A

MRPS12 PLEC

7.32e-04197524814_DN
DrugMetergoline [17692-51-2]; Down 200; 10uM; MCF7; HT_HG-U133A

MRPS12 PLEC

7.32e-04197525344_DN
DrugEthamsylate [2624-44-4]; Down 200; 15.2uM; MCF7; HT_HG-U133A

PLEC AHDC1

7.32e-04197527335_DN
Drugclozapine; Up 200; 10uM; MCF7; HT_HG-U133A

PLEC AHDC1

7.32e-04197526988_UP
Drugoxamic acid sodium salt; Up 200; 10000uM; MCF7; HG-U133A

MRPS12 PLEC

7.32e-0419752439_UP
DrugMethiazole; Down 200; 15uM; PC3; HT_HG-U133A

MRPS12 AHDC1

7.32e-04197524532_DN
DrugFursultiamine Hydrochloride [2105-43-3]; Down 200; 9.2uM; MCF7; HT_HG-U133A

PLEC AHDC1

7.40e-04198527349_DN
DrugIsoquinoline, 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro, hydrochloride; Down 200; 16.4uM; MCF7; HT_HG-U133A

MRPS12 AHDC1

7.40e-04198524810_DN
DrugTrichlorfon [52-68-6]; Down 200; 15.6uM; PC3; HT_HG-U133A

MRPS12 PLEC

7.40e-04198521797_DN
DrugHydroquinine hydrobromide hydrate [304695-81-6]; Down 200; 9.4uM; MCF7; HT_HG-U133A

PLEC AHDC1

7.40e-04198522767_DN
DrugAzathioprine [446-86-6]; Down 200; 14.4uM; MCF7; HT_HG-U133A

MRPS12 PLEC

7.40e-04198525262_DN
DrugAdiphenine hydrochloride [50-42-0]; Down 200; 11.4uM; PC3; HT_HG-U133A

MRPS12 PLEC

7.40e-04198521831_DN
DrugMerbromin [129-16-8]; Up 200; 5uM; MCF7; HT_HG-U133A

MRPS12 PLEC

7.40e-04198523439_UP
DrugNisoxetine hydrochloride [57754-86-6]; Down 200; 13uM; HL60; HT_HG-U133A

MRPS12 PLEC

7.40e-04198523117_DN
DrugFenofibrate [49562-28-9]; Down 200; 11uM; MCF7; HT_HG-U133A

MRPS12 PLEC

7.40e-04198527474_DN
DrugMeropenem [96036-03-2]; Down 200; 10.4uM; MCF7; HT_HG-U133A

PLEC AHDC1

7.40e-04198527180_DN
DrugBetazole hydrochloride; Down 200; 27uM; PC3; HT_HG-U133A

MRPS12 PLEC

7.40e-04198521812_DN
Drugchlorpromazine hydrochloride; Down 200; 1uM; HL60; HT_HG-U133A

PLEC AHDC1

7.40e-04198526176_DN
Drugaspirin, USP; Up 200; 100uM; HL60; HT_HG-U133A

MRPS12 PLEC

7.40e-04198521145_UP
DrugReserpinic acid hydrochloride; Down 200; 9.2uM; PC3; HT_HG-U133A

MRPS12 PLEC

7.40e-04198526603_DN
Drug2-propylpentanoic acid; Down 200; 50uM; MCF7; HT_HG-U133A

MRPS12 PLEC

7.40e-04198525219_DN
DrugBromopride [4093-35-0]; Up 200; 11.6uM; HL60; HT_HG-U133A

MRPS12 PLEC

7.40e-04198522182_UP
DrugFlucloxacillin sodium [1847-24-1]; Down 200; 8.4uM; HL60; HT_HG-U133A

MRPS12 PLEC

7.47e-04199523128_DN
DrugTetrahydroalstonine [6474-90-4]; Down 200; 11.4uM; MCF7; HT_HG-U133A

MRPS12 PLEC

7.47e-04199526209_DN
Drugtolbutamide; Up 200; 100uM; MCF7; HG-U133A

MRPS12 PLEC

7.47e-0419952142_UP
Drugrotenone; Down 200; 1uM; PC3; HT_HG-U133A

MRPS12 PLEC

7.47e-04199525920_DN
DrugSulmazole [73384-60-8]; Up 200; 14uM; HL60; HT_HG-U133A

MRPS12 PLEC

7.47e-04199522153_UP
DrugTracazolate hydrochloride [41094-88-6]; Down 200; 11.8uM; MCF7; HT_HG-U133A

MRPS12 PLEC

7.47e-04199527339_DN
DrugAdrenosterone [382-45-6]; Down 200; 13.4uM; MCF7; HT_HG-U133A

MRPS12 AHDC1

7.47e-04199525464_DN
DrugNadolol [42200-33-9]; Down 200; 13uM; HL60; HT_HG-U133A

MRPS12 PLEC

7.55e-04200523020_DN
DrugAC1L9K70

MRPS12 AHDC1

9.79e-0422852CID000446871
Diseaseepilepsy (implicated_via_orthology)

MRPS12 GRIN2D

3.00e-0416352DOID:1826 (implicated_via_orthology)
Diseaselean body mass

DIAPH3 PLEC

1.60e-0337952EFO_0004995
Diseasecortical thickness

DIAPH3 PLEC

1.32e-02111352EFO_0004840

Protein segments in the cluster

PeptideGeneStartEntry
PGEMPIILKRKRGRP

AHDC1

536

Q5TGY3
RESKMPRRKGPQHPP

DIAPH3

31

Q9NSV4
MHRLGPPKRPPRKLG

MRPS12

36

O15235
LKPRHPAHPMRGRLP

PLEC

931

Q15149
GPRGPRGPAKMLLLL

GRIN2D

6

O15399