Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	JUN kinase kinase kinase activity	MAP3K10 MAP3K21	1.63e-04	12	32	2	GO:0004706
Domain	MLK1/MLK2/MLK4	MAP3K10 MAP3K21	1.60e-05	4	31	2	IPR016231
Domain	MAP3K10	MAP3K10 MAP3K21	1.60e-05	4	31	2	IPR015785
Domain	Kinase-like_dom	KNDC1 MAP3K10 EIF2AK4 MAP3K21 WEE1 MAST3	2.30e-04	542	31	6	IPR011009
Domain	Ser/Thr_kinase_AS	MAP3K10 EIF2AK4 MAP3K21 WEE1 MAST3	2.80e-04	357	31	5	IPR008271
Domain	S_TKc	MAP3K10 EIF2AK4 MAP3K21 WEE1 MAST3	2.87e-04	359	31	5	SM00220
Domain	PROTEIN_KINASE_ST	MAP3K10 EIF2AK4 MAP3K21 WEE1 MAST3	2.99e-04	362	31	5	PS00108
Domain	Post-SET_dom	KMT2B EHMT2	3.15e-04	16	31	2	IPR003616
Domain	PostSET	KMT2B EHMT2	3.15e-04	16	31	2	SM00508
Domain	POST_SET	KMT2B EHMT2	3.15e-04	16	31	2	PS50868
Domain	PROTEIN_KINASE_ATP	MAP3K10 EIF2AK4 MAP3K21 WEE1 MAST3	8.79e-04	459	31	5	PS00107
Domain	Prot_kinase_dom	MAP3K10 EIF2AK4 MAP3K21 WEE1 MAST3	1.17e-03	489	31	5	IPR000719
Domain	PROTEIN_KINASE_DOM	MAP3K10 EIF2AK4 MAP3K21 WEE1 MAST3	1.21e-03	493	31	5	PS50011
Domain	SET	KMT2B EHMT2	2.10e-03	41	31	2	PF00856
Domain	SH3_1	MAP3K10 MAP3K21 PIK3R2	2.49e-03	164	31	3	PF00018
Domain	SET	KMT2B EHMT2	2.64e-03	46	31	2	SM00317
Domain	SET_dom	KMT2B EHMT2	3.11e-03	50	31	2	IPR001214
Domain	SET	KMT2B EHMT2	3.11e-03	50	31	2	PS50280
Domain	Protein_kinase_ATP_BS	MAP3K10 EIF2AK4 MAP3K21 WEE1	3.40e-03	379	31	4	IPR017441
Domain	Pkinase	MAP3K10 EIF2AK4 WEE1 MAST3	3.47e-03	381	31	4	PF00069
Domain	SH3	MAP3K10 MAP3K21 PIK3R2	5.40e-03	216	31	3	PS50002
Domain	SH3	MAP3K10 MAP3K21 PIK3R2	5.40e-03	216	31	3	SM00326
Domain	SH3_domain	MAP3K10 MAP3K21 PIK3R2	5.68e-03	220	31	3	IPR001452
Domain	SH3_9	MAP3K10 MAP3K21	7.40e-03	78	31	2	PF14604
Pubmed	MAP3K10 promotes the proliferation and decreases the sensitivity of pancreatic cancer cells to gemcitabine by upregulating Gli-1 and Gli-2.	MAP3K10 GLI2	2.62e-06	3	33	2	23178452
Pubmed	Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B.	EHMT2 PRRC2A	1.31e-05	6	33	2	2813433
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	EIF2AK4 MAP3K21 WEE1 BBC3 WDR33 PRRC2A NFKBIE	2.10e-05	922	33	7	27609421
Pubmed	A novel pro-Arg motif recognized by WW domains.	KMT2B PRRC2A	3.91e-05	10	33	2	10744724
Pubmed	The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.	GLI2 USP21	4.78e-05	11	33	2	27621083
Pubmed	P1 and cosmid clones define the organization of 280 kb of the mouse H-2 complex containing the Cps-1 and Hsp70 loci.	EHMT2 PRRC2A	5.73e-05	12	33	2	7993390
Pubmed	High-throughput mapping of a dynamic signaling network in mammalian cells.	EIF2AK4 WEE1 WDR33 USP21	1.05e-04	260	33	4	15761153
Pubmed	The DNA sequence and biology of human chromosome 19.	KISS1R KMT2B PIK3R2 MAST3	1.48e-04	284	33	4	15057824
Pubmed	Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks.	EIF2AK4 WEE1 USP21	2.34e-04	126	33	3	24319055
Pubmed	Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.	EHMT2 PRRC2A	2.38e-04	24	33	2	21323541
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	KMT2B EHMT2 WDR33	3.61e-04	146	33	3	23892456
Pubmed	Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function.	GJC2 ADRA2A	3.74e-04	30	33	2	27568567
Pubmed	p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.	EHMT2 RBM12B PRRC2A	4.63e-04	159	33	3	30581152
Pubmed	The genetic architecture of economic and political preferences.	ASTN2 EHMT2	5.69e-04	37	33	2	22566634
Pubmed	Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.	WDR33 PRRC2A	7.69e-04	43	33	2	34672947
Pubmed	A germline-specific class of small RNAs binds mammalian Piwi proteins.	KNDC1 KMT2B PRRC2A MAST3	8.41e-04	450	33	4	16751776
Interaction	SYDE1 interactions	MAP3K21 WDR33 MAST3 USP21	2.69e-05	110	32	4	int:SYDE1
Interaction	MAP3K21 interactions	MAP3K10 MAP3K21 MAST3 USP21	2.88e-05	112	32	4	int:MAP3K21
Interaction	DENND4C interactions	MAP3K21 WEE1 MAST3 USP21	6.90e-05	140	32	4	int:DENND4C
Interaction	KIF13B interactions	MAP3K21 WEE1 MAST3 USP21	7.29e-05	142	32	4	int:KIF13B
Interaction	ANKRD34A interactions	MAP3K21 MAST3 USP21	8.07e-05	53	32	3	int:ANKRD34A
Interaction	MAGI1 interactions	ESAM MAP3K21 MAST3 USP21	8.34e-05	147	32	4	int:MAGI1
Interaction	USP21 interactions	MAP3K21 GLI2 MAST3 USP21	1.19e-04	161	32	4	int:USP21
Interaction	KCTD3 interactions	MAP3K21 WEE1 MAST3 USP21	1.27e-04	164	32	4	int:KCTD3
Interaction	FAM110B interactions	MAP3K21 MAST3 USP21	1.63e-04	67	32	3	int:FAM110B
Interaction	FAM53C interactions	MAP3K21 MAST3 USP21	1.70e-04	68	32	3	int:FAM53C
Interaction	MAP3K10 interactions	MAP3K10 MAP3K21 PIK3R2	1.77e-04	69	32	3	int:MAP3K10
Interaction	CBY1 interactions	MAP3K21 WEE1 MAST3 USP21	1.90e-04	182	32	4	int:CBY1
Interaction	SRGAP2 interactions	MAP3K21 GLI2 MAST3 USP21	2.57e-04	197	32	4	int:SRGAP2
Interaction	NADK interactions	MAP3K21 MAST3 USP21	2.75e-04	80	32	3	int:NADK
Interaction	TIAM1 interactions	MAP3K21 WDR33 MAST3 USP21	2.99e-04	205	32	4	int:TIAM1
Interaction	BRSK2 interactions	KNDC1 MAP3K10 WEE1	4.02e-04	91	32	3	int:BRSK2
Interaction	RERE interactions	KMT2B EHMT2 PRRC2A	4.28e-04	93	32	3	int:RERE
Cytoband	1q42	HRES1 MAP3K21	2.77e-04	34	33	2	1q42
Cytoband	19p13.11	OCEL1 MAST3	1.28e-03	73	33	2	19p13.11
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	OCEL1 KISS1R PIK3R2 MAST3	2.47e-03	797	33	4	chr19p13
Cytoband	Ensembl 112 genes in cytogenetic band chr6p21	EHMT2 PRRC2A NFKBIE	5.59e-03	503	33	3	chr6p21
Cytoband	Ensembl 112 genes in cytogenetic band chr2q14	WDR33 GLI2	6.30e-03	165	33	2	chr2q14
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	MAP3K10 MAP3K21	4.58e-04	24	24	2	654
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2B EHMT2	9.23e-04	34	24	2	487
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KNDC1 GJC2 ADI1 MAST3	1.21e-05	199	32	4	67d8c7e5356f5d409d4f98e8338cf6c499fd7aee
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KNDC1 GJC2 ADI1 MAST3	1.24e-05	200	32	4	e5b4821fff40566c4a7dc3f74a14e27eb06b165d
Disease	health study participation	CABP1 PRRC2A PIK3R2 MAST3	5.06e-05	195	31	4	EFO_0010130
Disease	serum gamma-glutamyl transferase measurement	CABP1 ASTN2 PCNX3 PRRC2A MAST3 USP21	3.30e-04	914	31	6	EFO_0004532
Disease	membranous glomerulonephritis	EHMT2 PRRC2A	5.53e-04	33	31	2	EFO_0004254
Disease	multisite chronic pain	KNDC1 ASTN2	4.49e-03	95	31	2	EFO_0010100
Disease	Polydactyly	PIK3R2 GLI2	6.72e-03	117	31	2	C0152427

Protein segments in the cluster

Peptide	Gene	Start	Entry
IERHERPAGPGTPPP	EIF2AK4	656	Q9P2K8
PRERHGPRTPGGQLP	BBC3	31	Q96PG8
PSARMRGHGEPRRPP	EHMT2	581	Q96KQ7
PRHGPARDPGLPSRR	CABP1	86	Q9NZU7
LRGRPRLCFHPGPPP	ASTN2	16	O75129
FRRPPPEHFRRPPPE	RBM12B	731	Q8IXT5
RRPPPEHFRRPPPEH	RBM12B	756	Q8IXT5
RRPPPPRAGHDAPRR	OCEL1	26	Q9H607
RFPRGLSPPARPHGR	MAP3K10	716	Q02779
RRPGPRRAPRAHLPP	GJC2	116	Q5T442
PSEPHSPGRRPPRAG	NFKBIE	91	O00221
PPLRRHSPPGRAPRR	PCNX3	396	Q9H6A9
HSPPGRAPRRPLLEG	PCNX3	401	Q9H6A9
ALGEPPRRGPPRPRD	ERFE	266	Q4G0M1
RRPRRPGPSDPAAPH	KISS1R	346	Q969F8
PRPPLEPSPTGRHRG	GLI2	1371	P10070
PQDPRSPGPAPRHRR	HRES1	46	P13985
SPGPAPRHRRPPRPD	HRES1	51	P13985
EPGGPPAPRRRTPRE	KMT2B	1096	Q9UMN6
RGPRPLPARPRDGAP	PIK3R2	91	O00459
ARALRPPHGPPRPGA	ESAM	316	Q96AP7
PGHPPAPARSPRLRR	MAST3	1206	O60307
RERPAPGNAGPRRPP	KNDC1	216	Q76NI1
DRDDGRYPPRPRPRP	XG	91	P55808
VRPPRRGRGPHEPRR	RSPRY1	81	Q96DX4
PRAPGPRRARRIPPH	MAP3K21	221	Q5TCX8
PPRRPPPAPHDGDRK	PRRC2A	1706	P48634
PPGPPAGRRHLPLSR	ST6GALNAC6	16	Q969X2
RAPPRPPRPHGRRTG	B4GALNT4	566	Q76KP1
HAERPPGPRRPERGP	ADRA2A	316	P08913
PRHPRPRRPGGPALR	C10orf95	111	Q9H7T3
GEGHRPRRPRGALPP	RHBDD3	131	Q9Y3P4
EGRRSPRPDHPGTPP	WEE1	161	P30291
PRPRGPLRADHGVPL	USP21	76	Q9UK80
GGRRPGPPEEPPREL	SOGA3	136	Q5TF21
CRGPPDRRGPHPDFP	WDR33	996	Q9C0J8
RRGGPGPPFPPDHRE	WDR33	1046	Q9C0J8
RGAPPRHEGRAPPRG	WDR33	1106	Q9C0J8
PGDPRQPHRPDPGRP	ADI1	11	Q9BV57