Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Abnormality of the hepatic vasculature	ZFYVE19 STOX1 ALMS1 CALR	1.93e-05	92	10	4	HP:0006707
Domain	-	CALR CANX	1.02e-05	3	35	2	2.10.250.10
Domain	CALRETICULIN_REPEAT	CALR CANX	1.02e-05	3	35	2	PS00805
Domain	Calret/calnex	CALR CANX	2.04e-05	4	35	2	IPR001580
Domain	Calreticulin	CALR CANX	2.04e-05	4	35	2	PF00262
Domain	CALRETICULIN_1	CALR CANX	2.04e-05	4	35	2	PS00803
Domain	CALRETICULIN_2	CALR CANX	2.04e-05	4	35	2	PS00804
Domain	Calret/calnex_CS	CALR CANX	2.04e-05	4	35	2	IPR018124
Domain	Calreticulin/calnexin_P_dom	CALR CANX	3.40e-05	5	35	2	IPR009033
Domain	DNA/RNA_helicase_DEAH_CS	DHX16 CHD2	1.95e-03	35	35	2	IPR002464
Domain	DEAH_ATP_HELICASE	DHX16 CHD2	2.30e-03	38	35	2	PS00690
Domain	Nucleotide-bd_a/b_plait	PARP10 LARP6 RBM12B	1.23e-02	258	35	3	IPR012677
Domain	-	CALR CANX	1.37e-02	95	35	2	2.60.120.200
Domain	Helicase_C	DHX16 CHD2	1.71e-02	107	35	2	PF00271
Domain	HELICc	DHX16 CHD2	1.71e-02	107	35	2	SM00490
Domain	Helicase_C	DHX16 CHD2	1.74e-02	108	35	2	IPR001650
Domain	HELICASE_CTER	DHX16 CHD2	1.77e-02	109	35	2	PS51194
Pathway	REACTOME_CALNEXIN_CALRETICULIN_CYCLE	CALR CANX	5.80e-05	7	24	2	MM15592
Pathway	REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE	CALR CANX	2.88e-04	15	24	2	MM15175
Pathway	REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC	CALR CANX	8.14e-04	25	24	2	MM15713
Pathway	REACTOME_CALNEXIN_CALRETICULIN_CYCLE	CALR CANX	8.81e-04	26	24	2	M907
Pathway	REACTOME_TRANSLATION_OF_SARS_COV_1_STRUCTURAL_PROTEINS	PARP10 CANX	1.10e-03	29	24	2	M39014
Pathway	REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC	CALR CANX	1.10e-03	29	24	2	M1062
Pubmed	Calreticulin is required for development of the cumulus oocyte complex and female fertility.	CALR CANX	9.84e-07	2	35	2	26388295
Pubmed	Contrasting functions of calreticulin and calnexin in glycoprotein folding and ER quality control.	CALR CANX	9.84e-07	2	35	2	14731400
Pubmed	Calreticulin interacts with newly synthesized human immunodeficiency virus type 1 envelope glycoprotein, suggesting a chaperone function similar to that of calnexin.	CALR CANX	9.84e-07	2	35	2	8550632
Pubmed	Beyond lectins: the calnexin/calreticulin chaperone system of the endoplasmic reticulum.	CALR CANX	9.84e-07	2	35	2	16467570
Pubmed	Compromised calnexin function in calreticulin-deficient cells.	CALR CANX	9.84e-07	2	35	2	12727205
Pubmed	Differential downregulation of endoplasmic reticulum-residing chaperones calnexin and calreticulin in human metastatic melanoma.	CALR CANX	9.84e-07	2	35	2	14732231
Pubmed	Calnexin, calreticulin and the folding of glycoproteins.	CALR CANX	9.84e-07	2	35	2	17708944
Pubmed	Functional interplay of SP family members and nuclear factor Y is essential for transcriptional activation of the human Calreticulin gene.	SP3 CALR	2.95e-06	3	35	2	26162987
Pubmed	Promotion of transferrin folding by cyclic interactions with calnexin and calreticulin.	CALR CANX	2.95e-06	3	35	2	9312001
Pubmed	RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy.	CALR CANX	2.95e-06	3	35	2	36224200
Pubmed	Chaperone interactions of the metalloproteinase meprin A in the secretory or proteasomal-degradative pathway.	CALR CANX	2.95e-06	3	35	2	11795871
Pubmed	Substrate specificity of the oxidoreductase ERp57 is determined primarily by its interaction with calnexin and calreticulin.	CALR CANX	2.95e-06	3	35	2	19054761
Pubmed	The measles virus (MV) glycoproteins interact with cellular chaperones in the endoplasmic reticulum and MV infection upregulates chaperone expression.	CALR CANX	2.95e-06	3	35	2	11765911
Pubmed	ER-60 domains responsible for interaction with calnexin and calreticulin.	CALR CANX	2.95e-06	3	35	2	15236594
Pubmed	Localization of the lectin, ERp57 binding, and polypeptide binding sites of calnexin and calreticulin.	CALR CANX	2.95e-06	3	35	2	12052826
Pubmed	The glut 1 glucose transporter interacts with calnexin and calreticulin.	CALR CANX	2.95e-06	3	35	2	8662691
Pubmed	Molecular chaperones stimulate the functional expression of the cocaine-sensitive serotonin transporter.	CALR CANX	2.95e-06	3	35	2	10364189
Pubmed	Trafficking-deficient G572R-hERG and E637K-hERG activate stress and clearance pathways in endoplasmic reticulum.	CALR CANX	2.95e-06	3	35	2	22242185
Pubmed	A novel quality control compartment derived from the endoplasmic reticulum.	CALR CANX	5.90e-06	4	35	2	11408579
Pubmed	In vivo genetic mutations define predominant functions of the human T-cell leukemia/lymphoma virus p12I protein.	CALR CANX	5.90e-06	4	35	2	18791162
Pubmed	Endoplasmic reticulum glucosidase II is composed of a catalytic subunit, conserved from yeast to mammals, and a tightly bound noncatalytic HDEL-containing subunit.	CALR CANX	5.90e-06	4	35	2	8910335
Pubmed	Cell surface targeting of myelin oligodendrocyte glycoprotein (MOG) in the absence of endoplasmic reticulum molecular chaperones.	CALR CANX	5.90e-06	4	35	2	21172390
Pubmed	Calnexin, calreticulin, and ERp57 cooperate in disulfide bond formation in human CD1d heavy chain.	CALR CANX	5.90e-06	4	35	2	12239218
Pubmed	The low-density lipoprotein receptor-related protein associates with calnexin, calreticulin, and protein disulfide isomerase in receptor-associated-protein-deficient fibroblasts.	CALR CANX	5.90e-06	4	35	2	14980518
Pubmed	Soluble tyrosinase is an endoplasmic reticulum (ER)-associated degradation substrate retained in the ER by calreticulin and BiP/GRP78 and not calnexin.	CALR CANX	5.90e-06	4	35	2	15677452
Pubmed	Association of the thyrotropin receptor with calnexin, calreticulin and BiP. Efects on the maturation of the receptor.	CALR CANX	5.90e-06	4	35	2	12383251
Pubmed	The role of N-glycan in folding, trafficking and pathogenicity of myelin oligodendrocyte glycoprotein (MOG).	CALR CANX	5.90e-06	4	35	2	25541284
Pubmed	Differential interaction of coagulation factor VIII and factor V with protein chaperones calnexin and calreticulin.	CALR CANX	5.90e-06	4	35	2	9525969
Pubmed	Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling.	CALR CANX	9.82e-06	5	35	2	20520781
Pubmed	ERp57 functions as a subunit of specific complexes formed with the ER lectins calreticulin and calnexin.	CALR CANX	9.82e-06	5	35	2	10436013
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	DHX16 NGRN MRPS5 CHD2 RBM12B CEBPZ CANX	1.35e-05	807	35	7	22681889
Pubmed	The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo.	CALR CANX	1.47e-05	6	35	2	10929008
Pubmed	Altered expression of glycoproteins on the cell surface of Jurkat cells during etoposide-induced apoptosis: shedding and intracellular translocation of glycoproteins.	CALR CANX	1.47e-05	6	35	2	19524015
Pubmed	The p65 subunit of NF-κB inhibits COL1A1 gene transcription in human dermal and scleroderma fibroblasts through its recruitment on promoter by protein interaction with transcriptional activators (c-Krox, Sp1, and Sp3).	SP3 CEBPZ	2.06e-05	7	35	2	22139845
Pubmed	Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading.	CALR CANX	2.06e-05	7	35	2	11823531
Pubmed	Genes regulating MHC class I processing of antigen.	CALR CANX	2.74e-05	8	35	2	10047538
Pubmed	Deletion of Tmtc4 activates the unfolded protein response and causes postnatal hearing loss.	CALR CANX	2.74e-05	8	35	2	30188326
Pubmed	GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development.	CALR CANX	3.53e-05	9	35	2	16847323
Pubmed	Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip.	CALR CANX	3.53e-05	9	35	2	22572157
Pubmed	ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly.	CALR CANX	4.40e-05	10	35	2	9545232
Pubmed	CEP192 interacts physically and functionally with the K63-deubiquitinase CYLD to promote mitotic spindle assembly.	ALMS1 RBM12B	4.40e-05	10	35	2	22895009
Pubmed	Endoplasmic reticulum stress during the embryonic development of the central nervous system in the mouse.	CALR CANX	5.38e-05	11	35	2	17913437
Pubmed	Getting in and out from calnexin/calreticulin cycles.	CALR CANX	7.62e-05	13	35	2	18303019
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	CHD2 ALMS1 WDHD1 CEBPZ SENP3	1.02e-04	469	35	5	27634302
Pubmed	Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins.	CALR CANX	1.02e-04	15	35	2	17090218
Pubmed	Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method.	PEAK1 ARHGEF28	1.02e-04	15	35	2	12056414
Pubmed	The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons.	CALR CANX	1.17e-04	16	35	2	19943849
Pubmed	Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers.	CALR CANX	1.33e-04	17	35	2	32938586
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	SCRIB PEAK1 ALMS1 CANX	1.39e-04	263	35	4	34702444
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	DHX16 CRACD WDHD1 CALR CANX	1.45e-04	506	35	5	30890647
Pubmed	Mitochondrial Raf1 Regulates Glutamine Catabolism.	NAA25 PEAK1 CALR CANX	1.97e-04	288	35	4	38496616
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	DHX16 MRPS5 CHD2 CEBPZ CALR CANX SENP3	2.93e-04	1318	35	7	30463901
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	PEAK1 HDAC10 CALR CANX	3.01e-04	322	35	4	26514267
Pubmed	Purification and identification of G protein-coupled receptor protein complexes under native conditions.	CALR CANX	4.49e-04	31	35	2	17215244
Pubmed	Hepatic lipase maturation: a partial proteome of interacting factors.	CALR CANX	4.49e-04	31	35	2	19136429
Pubmed	The unfolded protein response: integrating stress signals through the stress sensor IRE1α.	CALR CANX	4.49e-04	31	35	2	22013210
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DHX16 SCRIB ARHGEF28 ARVCF SENP3	4.58e-04	650	35	5	38777146
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	DHX16 SP3 SCRIB WDHD1 CALR	4.68e-04	653	35	5	33742100
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DHX16 CHD2 CEBPZ CALR CANX	4.68e-04	653	35	5	22586326
Pubmed	A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair.	CCDC88B CALR CANX	4.93e-04	153	35	3	27462432
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	DHX16 SCRIB RBM12B CEBPZ CALR CANX	5.02e-04	1024	35	6	24711643
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	SCRIB PEAK1 ARVCF CEBPZ CALR CANX	5.70e-04	1049	35	6	27880917
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	SCRIB CEBPZ CALR CANX SENP3	6.29e-04	697	35	5	28298427
Pubmed	A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.	PIEZO2 ARHGEF28	7.87e-04	41	35	2	23509962
Pubmed	Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.	CALR CANX	9.48e-04	45	35	2	1286667
Pubmed	Defining the Na+/H+ exchanger NHE1 interactome in triple-negative breast cancer cells.	CALR CANX	9.90e-04	46	35	2	27751915
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF28 CCDC88B RBM12B MAP4K2	3.56e-06	133	35	4	f6e9a1301a3379847b215303a9b0c028841e2cc0
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF28 CCDC88B RBM12B MAP4K2	3.56e-06	133	35	4	292ecfcadbaf15e0d34a3ab9bf511ab1065888bd
ToppCell	CV-Mild-3\|Mild / Virus stimulation, Condition and Cluster	PODXL2 WDHD1 ARVCF SPDYE3	8.56e-06	166	35	4	5599f90fc0e15a3670b03187085eba91228390a2
Drug	Ethacrynic acid [58-54-8]; Down 200; 13.2uM; MCF7; HT_HG-U133A	FANCE POLL PODXL2 ARVCF PADI2 CALR	4.54e-07	193	35	6	3181_DN
Drug	AC1N3C6T	SP3 CALR	1.37e-05	4	35	2	CID004110181
Disease	MYELODYSPLASTIC SYNDROME	FANCE CALR	2.26e-03	67	31	2	C3463824
Disease	diastolic blood pressure, systolic blood pressure	PIEZO2 ALMS1 MAP4K2 CANX	5.09e-03	670	31	4	EFO_0006335, EFO_0006336

Protein segments in the cluster

Peptide	Gene	Start	Entry
EREPNEDSKPRDAEW	ARVCF	501	O00192
GEEEEEEEEPPLWLE	CCDC88B	36	A6NC98
LILDDDDRERPWEPA	BCAR3	476	O75815
LPWPGELEEEEEEEE	ALMS1	6	Q8TCU4
EKPESEDEWERTERE	DHX16	156	O60231
DVDPRPEAEEEELPW	ZFYVE19	406	Q96K21
AKIPRREEGEEAEEW	POLL	26	Q9UGP5
RPLEEDWRRPLEEDF	RBM12B	621	Q8IXT5
EEDLRWLPEEDFRRP	RBM12B	656	Q8IXT5
RRKETDPLNEPWEEE	MAP4K2	341	Q12851
EPPRENRIQEEEWDK	ARHGEF28	591	Q8N1W1
WHMPPREEEEEEEEE	PODXL2	156	Q9NZ53
EPDPDSDWEPEEREL	NGRN	36	Q9NPE2
RLLPWEDPDDPEKDE	PEAK1	1401	Q9H792
NEREDLEQEWKPPDE	LARP6	76	Q9BRS8
PEPREEEEEEQELRW	ANKRD65	6	E5RJM6
DRETPWLPKEDCRDE	PADI2	156	Q9Y2J8
LLWDDPECEIERPER	HDAC10	16	Q969S8
DEEELEERPHKDWDE	CHD2	1031	O14647
EERPHKDWDEIIPEE	CHD2	1036	O14647
EAPGWEDAERREREE	CRACD	296	Q6ZU35
PEDWDERAKIDDPTD	CALR	216	P27797
IEDPEDRKPEDWDER	CANX	276	P27824
DRKPEDWDERPKIPD	CANX	281	P27824
VPDPDAEKPEDWDED	CANX	331	P27824
RCWEEEEDHEKERPE	FANCE	221	Q9HB96
WRPEEAVEDPDEEDE	CEBPZ	16	Q03701
DLDGEDWLPRELEEE	PARP10	606	Q53GL7
EPEDEVPDVKLDWED	MRPS5	396	P82675
REEEEWEATLGPDRE	PNMA3	331	Q9UL41
APWAPRAQKEEEEEE	SCRIB	651	Q14160
DEDEEEEVAAWRLPP	SENP3	86	Q9H4L4
PEPEELWEAEMERLR	TMC8	16	Q8IU68
EWPVRDEDDLDNIPR	STOX1	341	Q6ZVD7
DEPEKELAPEPEETW	SPDYE3	281	A6NKU9
ADIRIKEEEPDPEEW	SP3	546	Q02447
DVRIWEDLDDDDPKF	WDHD1	36	O75717
RWEPSDESSEKREEE	PIEZO2	451	Q9H5I5
SKEGPVEWEDREDEP	PIEZO2	1616	Q9H5I5
RPEEDDIPWEDLRDN	NAA25	641	Q14CX7