Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	endopeptidase activity	CAPN12 ADAM19 PRSS41 PSMB7 ADAMTS13 CTRL TMPRSS11B	1.51e-04	430	54	7	GO:0004175
GeneOntologyMolecularFunction	histone H3K9 monomethyltransferase activity	SETDB2 EHMT2	1.99e-04	8	54	2	GO:0140948
GeneOntologyMolecularFunction	histone H3K9me2 methyltransferase activity	SETDB2 EHMT2	3.19e-04	10	54	2	GO:0140947
GeneOntologyMolecularFunction	protein phosphatase 2B binding	AKAP1 ATP2B4	3.19e-04	10	54	2	GO:0030346
GeneOntologyMolecularFunction	peptidase activity	CAPN12 ADAM19 PRSS41 AMZ1 PSMB7 ADAMTS13 CTRL TMPRSS11B	3.49e-04	654	54	8	GO:0008233
GeneOntologyMolecularFunction	P-type calcium transporter activity	ATP2B1 ATP2B4	3.89e-04	11	54	2	GO:0005388
GeneOntologyMolecularFunction	protein kinase A binding	AKAP9 LRRK2 AKAP1	5.19e-04	58	54	3	GO:0051018
GeneOntologyMolecularFunction	histone H3K9 methyltransferase activity	SETDB2 EHMT2	5.49e-04	13	54	2	GO:0046974
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	LRP1 SORL1	8.41e-04	16	54	2	GO:0005041
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	LRP1 SORL1	1.46e-03	21	54	2	GO:0030228
GeneOntologyMolecularFunction	protein kinase A regulatory subunit binding	AKAP9 AKAP1	2.07e-03	25	54	2	GO:0034237
GeneOntologyMolecularFunction	heparan sulfate proteoglycan binding	LRP1 SEMA5A	2.78e-03	29	54	2	GO:0043395
GeneOntologyMolecularFunction	ferrous iron binding	EGLN2 NT5E	2.97e-03	30	54	2	GO:0008198
GeneOntologyCellularComponent	side of membrane	SCUBE1 TRAF6 ADAM19 CD177 PRSS41 NT5E LRRK2 LRP1 PLAUR ATP2B1	7.03e-05	875	54	10	GO:0098552
Domain	EGF_3	ATRN SCUBE1 ADAM19 TENM4 TENM1 LRP1 LTBP2 SORL1	3.03e-07	235	53	8	PS50026
Domain	EGF-like_dom	ATRN SCUBE1 ADAM19 TENM4 TENM1 LRP1 LTBP2 SORL1	4.71e-07	249	53	8	IPR000742
Domain	EGF-like_CS	ATRN SCUBE1 ADAM19 TENM4 TENM1 LRP1 LTBP2 SORL1	6.72e-07	261	53	8	IPR013032
Domain	EGF_extracell	ATRN ADAM19 TENM4 TENM1 LTBP2	7.36e-07	60	53	5	IPR013111
Domain	EGF_2	ATRN ADAM19 TENM4 TENM1 LTBP2	7.36e-07	60	53	5	PF07974
Domain	EGF_2	ATRN SCUBE1 ADAM19 TENM4 TENM1 LRP1 LTBP2 SORL1	7.54e-07	265	53	8	PS01186
Domain	EGF	ATRN SCUBE1 TENM4 TENM1 LRP1 LTBP2 SORL1	4.30e-06	235	53	7	SM00181
Domain	-	TENM4 TENM1 LRP1 SORL1	4.42e-06	39	53	4	2.120.10.30
Domain	EGF_1	ATRN SCUBE1 ADAM19 TENM4 TENM1 LRP1 LTBP2	7.35e-06	255	53	7	PS00022
Domain	ATP2B1/4	ATP2B1 ATP2B4	7.90e-06	2	53	2	IPR030319
Domain	6-blade_b-propeller_TolB-like	TENM4 TENM1 LRP1 SORL1	8.63e-06	46	53	4	IPR011042
Domain	ATP_Ca_trans_C	ATP2B1 ATP2B4	4.72e-05	4	53	2	IPR022141
Domain	Tox-GHH_dom	TENM4 TENM1	4.72e-05	4	53	2	IPR028916
Domain	Ten_N	TENM4 TENM1	4.72e-05	4	53	2	IPR009471
Domain	Ten_N	TENM4 TENM1	4.72e-05	4	53	2	PF06484
Domain	ATP_Ca_trans_C	ATP2B1 ATP2B4	4.72e-05	4	53	2	PF12424
Domain	TENEURIN_N	TENM4 TENM1	4.72e-05	4	53	2	PS51361
Domain	P-type_ATPase_IIB	ATP2B1 ATP2B4	4.72e-05	4	53	2	IPR006408
Domain	Tox-GHH	TENM4 TENM1	4.72e-05	4	53	2	PF15636
Domain	YD	TENM4 TENM1	7.86e-05	5	53	2	IPR006530
Domain	ATPase_P-typ_cyto_domN	ATP10B ATP2B1 ATP2B4	1.32e-04	35	53	3	IPR023299
Domain	P_typ_ATPase	ATP10B ATP2B1 ATP2B4	1.44e-04	36	53	3	IPR001757
Domain	ATPase_P-typ_P_site	ATP10B ATP2B1 ATP2B4	1.44e-04	36	53	3	IPR018303
Domain	ATPASE_E1_E2	ATP10B ATP2B1 ATP2B4	1.44e-04	36	53	3	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP10B ATP2B1 ATP2B4	1.57e-04	37	53	3	IPR008250
Domain	E1-E2_ATPase	ATP10B ATP2B1 ATP2B4	1.57e-04	37	53	3	PF00122
Domain	PreSET	SETDB2 EHMT2	1.64e-04	7	53	2	SM00468
Domain	Pre-SET	SETDB2 EHMT2	1.64e-04	7	53	2	PF05033
Domain	Pre-SET_dom	SETDB2 EHMT2	1.64e-04	7	53	2	IPR007728
Domain	PRE_SET	SETDB2 EHMT2	1.64e-04	7	53	2	PS50867
Domain	CUB	ATRN SCUBE1 ADAMTS13	4.57e-04	53	53	3	PS01180
Domain	CUB_dom	ATRN SCUBE1 ADAMTS13	5.67e-04	57	53	3	IPR000859
Domain	NHL	TENM4 TENM1	6.04e-04	13	53	2	PS51125
Domain	Ldl_recept_b	LRP1 SORL1	7.03e-04	14	53	2	PF00058
Domain	LDLRB	LRP1 SORL1	7.03e-04	14	53	2	PS51120
Domain	DH_1	ARHGEF28 ARHGEF3 ARHGEF17	7.60e-04	63	53	3	PS00741
Domain	LY	LRP1 SORL1	8.10e-04	15	53	2	SM00135
Domain	LDLR_classB_rpt	LRP1 SORL1	8.10e-04	15	53	2	IPR000033
Domain	-	ATP2B1 ATP2B4	9.24e-04	16	53	2	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP2B1 ATP2B4	9.24e-04	16	53	2	IPR023298
Domain	RhoGEF	ARHGEF28 ARHGEF3 ARHGEF17	9.49e-04	68	53	3	SM00325
Domain	Growth_fac_rcpt_	ATRN SCUBE1 LRP1 LTBP2	9.98e-04	156	53	4	IPR009030
Domain	RhoGEF	ARHGEF28 ARHGEF3 ARHGEF17	1.03e-03	70	53	3	PF00621
Domain	DH_2	ARHGEF28 ARHGEF3 ARHGEF17	1.03e-03	70	53	3	PS50010
Domain	ATPase_P-typ_cation-transptr_C	ATP2B1 ATP2B4	1.05e-03	17	53	2	IPR006068
Domain	Cation_ATPase_C	ATP2B1 ATP2B4	1.05e-03	17	53	2	PF00689
Domain	DH-domain	ARHGEF28 ARHGEF3 ARHGEF17	1.08e-03	71	53	3	IPR000219
Domain	-	ARHGEF28 ARHGEF3 ARHGEF17	1.08e-03	71	53	3	1.20.900.10
Domain	Cation_ATPase_N	ATP2B1 ATP2B4	1.17e-03	18	53	2	PF00690
Domain	Cation_ATPase_N	ATP2B1 ATP2B4	1.17e-03	18	53	2	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP2B1 ATP2B4	1.31e-03	19	53	2	IPR004014
Domain	UPAR_LY6	CD177 PLAUR	1.45e-03	20	53	2	PF00021
Domain	HAD-like_dom	ATP10B ATP2B1 ATP2B4	1.47e-03	79	53	3	IPR023214
Domain	LY6_UPAR	CD177 PLAUR	1.76e-03	22	53	2	PS00983
Domain	LY6_UPA_recep-like	CD177 PLAUR	1.76e-03	22	53	2	IPR016054
Domain	Quino_amine_DH_bsu	NBAS LRRK2	1.76e-03	22	53	2	IPR011044
Domain	EGF_CA	SCUBE1 LRP1 LTBP2	1.87e-03	86	53	3	PF07645
Domain	cEGF	SCUBE1 LRP1	2.46e-03	26	53	2	IPR026823
Domain	cEGF	SCUBE1 LRP1	2.46e-03	26	53	2	PF12662
Domain	EGF_Ca-bd_CS	SCUBE1 LRP1 LTBP2	2.64e-03	97	53	3	IPR018097
Domain	ACR	ADAM19 ADAMTS13	2.65e-03	27	53	2	SM00608
Domain	ADAM_Cys-rich	ADAM19 ADAMTS13	2.65e-03	27	53	2	IPR006586
Domain	ZINC_PROTEASE	ADAM19 AMZ1 ADAMTS13	2.71e-03	98	53	3	PS00142
Domain	EGF_CA	SCUBE1 LRP1 LTBP2	2.79e-03	99	53	3	PS01187
Domain	ASX_HYDROXYL	SCUBE1 LRP1 LTBP2	2.87e-03	100	53	3	PS00010
Domain	TRYPSIN_HIS	PRSS41 CTRL TMPRSS11B	3.12e-03	103	53	3	IPR018114
Domain	TRYPSIN_SER	PRSS41 CTRL TMPRSS11B	3.39e-03	106	53	3	PS00135
Pubmed	LRP1 regulates remodeling of the extracellular matrix by fibroblasts.	LRP1 PLAUR	2.37e-06	2	54	2	19699300
Pubmed	Functional and structural demonstration of the presence of Ca-ATPase (PMCA) in both microvillous and basal plasma membranes from syncytiotrophoblast of human term placenta.	ATP2B1 ATP2B4	2.37e-06	2	54	2	18657858
Pubmed	Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity.	LRP1 PLAUR	2.37e-06	2	54	2	11359936
Pubmed	The soluble form of LR11 protein is a regulator of hypoxia-induced, urokinase-type plasminogen activator receptor (uPAR)-mediated adhesion of immature hematological cells.	PLAUR SORL1	2.37e-06	2	54	2	23486467
Pubmed	Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR.	LRP1 PLAUR	2.37e-06	2	54	2	19008962
Pubmed	The influence of membrane lipid structure on plasma membrane Ca2+ -ATPase activity.	ATP2B1 ATP2B4	2.37e-06	2	54	2	16412504
Pubmed	Distinct roles of PMCA isoforms in Ca2+ homeostasis of bladder smooth muscle: evidence from PMCA gene-ablated mice.	ATP2B1 ATP2B4	2.37e-06	2	54	2	16956963
Pubmed	Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23.	ATP2B1 ATP2B4	2.37e-06	2	54	2	1674727
Pubmed	LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration.	PLAUR SORL1	2.37e-06	2	54	2	14764453
Pubmed	Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4.	ATP2B1 ATP2B4	2.37e-06	2	54	2	15178683
Pubmed	Role of plasma membrane Ca2+-ATPase in contraction-relaxation processes of the bladder: evidence from PMCA gene-ablated mice.	ATP2B1 ATP2B4	2.37e-06	2	54	2	16291816
Pubmed	Regulation of plasma membrane Ca2+-ATPase by small GTPases and phosphoinositides in human platelets.	ATP2B1 ATP2B4	2.37e-06	2	54	2	10748016
Pubmed	Selective upregulation of the expression of plasma membrane calcium ATPase isoforms upon differentiation and 1,25(OH)2D3-vitamin treatment of colon cancer cells.	ATP2B1 ATP2B4	2.37e-06	2	54	2	26116539
Pubmed	Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival.	ATP2B1 ATP2B4	2.37e-06	2	54	2	23266958
Pubmed	A complex of Neuroplastin and Plasma Membrane Ca2+ ATPase controls T cell activation.	ATP2B1 ATP2B4	7.09e-06	3	54	2	28827723
Pubmed	Plasma membrane Ca2+ ATPase 1 (PMCA1) but not PMCA4 is critical for B-cell development and Ca2+ homeostasis in mice.	ATP2B1 ATP2B4	7.09e-06	3	54	2	33098669
Pubmed	Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.	LRP1 SORL1	7.09e-06	3	54	2	28799085
Pubmed	CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity.	ATP2B1 ATP2B4	7.09e-06	3	54	2	15133509
Pubmed	Cell-specific expression of plasma membrane calcium ATPase isoforms in retinal neurons.	ATP2B1 ATP2B4	1.42e-05	4	54	2	12209837
Pubmed	Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues.	TENM4 TENM1	1.42e-05	4	54	2	10225957
Pubmed	Expression and role of calcium-ATPase pump and sodium-calcium exchanger in differentiated trophoblasts from human term placenta.	ATP2B1 ATP2B4	1.42e-05	4	54	2	12784250
Pubmed	Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis.	GATA4 LRP1	1.42e-05	4	54	2	12413896
Pubmed	Expression and function of the urokinase type plasminogen activator during mouse hemochorial placental development.	LRP1 PLAUR	1.42e-05	4	54	2	9733098
Pubmed	Calcium pumps of plasma membrane and cell interior.	ATP2B1 ATP2B4	1.42e-05	4	54	2	15101689
Pubmed	The plasma membrane calcium pump in health and disease.	ATP2B1 ATP2B4	1.42e-05	4	54	2	23413890
Pubmed	Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.	ATP2B1 ATP2B4	1.42e-05	4	54	2	8245032
Pubmed	Plasma membrane calcium ATPases as critical regulators of calcium homeostasis during neuronal cell function.	ATP2B1 ATP2B4	1.42e-05	4	54	2	10577388
Pubmed	Structural organization, ion transport, and energy transduction of P-type ATPases.	ATP2B1 ATP2B4	1.42e-05	4	54	2	8634322
Pubmed	Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.	ATP2B1 ATP2B4	1.42e-05	4	54	2	7989379
Pubmed	Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.	ATP2B1 ATP2B4	1.42e-05	4	54	2	11152753
Pubmed	All four members of the Ten-m/Odz family of transmembrane proteins form dimers.	TENM4 TENM1	1.42e-05	4	54	2	12000766
Pubmed	The sarcolemmal calcium pump, alpha-1 syntrophin, and neuronal nitric-oxide synthase are parts of a macromolecular protein complex.	ATP2B1 ATP2B4	1.42e-05	4	54	2	16735509
Pubmed	PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growth†.	ATP2B1 ATP2B4	1.42e-05	4	54	2	36130203
Pubmed	Ca2+ Homeostasis by Plasma Membrane Ca2+ ATPase (PMCA) 1 Is Essential for the Development of DP Thymocytes.	ATP2B1 ATP2B4	1.42e-05	4	54	2	36674959
Pubmed	Developmental expression of the four plasma membrane calcium ATPase (Pmca) genes in the mouse.	ATP2B1 ATP2B4	1.42e-05	4	54	2	10434059
Pubmed	The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain.	LRP1 SORL1	1.42e-05	4	54	2	23283348
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	CAPN12 ADAM19 PRSS41 EHMT2 LRP1 ATP2B1 ATP2B4 HACD1	1.61e-05	730	54	8	34857952
Pubmed	Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family.	LRP1 SORL1	2.36e-05	5	54	2	17326667
Pubmed	Increased maternofetal calcium flux in parathyroid hormone-related protein-null mice.	ATP2B1 ATP2B4	2.36e-05	5	54	2	18258656
Pubmed	Breakpoint features of genomic rearrangements in neuroblastoma with unbalanced translocations and chromothripsis.	NBAS TENM4	2.36e-05	5	54	2	23991058
Pubmed	Differential regulation of the apical plasma membrane Ca(2+) -ATPase by protein kinase A in parotid acinar cells.	ATP2B1 ATP2B4	2.36e-05	5	54	2	17938178
Pubmed	Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR.	SETDB2 EHMT2	2.36e-05	5	54	2	18498648
Pubmed	Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.	LRP1 SORL1	2.36e-05	5	54	2	19047013
Pubmed	Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration.	LRP1 PLAUR	3.54e-05	6	54	2	16601674
Pubmed	Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants.	ATP2B1 ATP2B4	3.54e-05	6	54	2	12763866
Pubmed	Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange.	ATP2B1 ATP2B4	3.54e-05	6	54	2	12767889
Pubmed	POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.	ATP2B1 ATP2B4	4.94e-05	7	54	2	22084111
Pubmed	Embryo implantation in mouse: fetomaternal coordination in the pattern of expression of uPA, uPAR, PAI-1 and alpha 2MR/LRP genes.	LRP1 PLAUR	4.94e-05	7	54	2	8798151
Pubmed	The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain.	TENM4 TENM1	4.94e-05	7	54	2	12915301
Pubmed	Gene knockout studies of Ca2+-transporting ATPases.	ATP2B1 ATP2B4	6.59e-05	8	54	2	10951186
Pubmed	Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25.	TENM4 TENM1	6.59e-05	8	54	2	10331952
Pubmed	Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.	TUBGCP6 AKAP9 MIB1 LRRCC1	8.01e-05	146	54	4	21399614
Pubmed	Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle.	ATP2B1 ATP2B4	8.46e-05	9	54	2	12660151
Pubmed	Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.	LRP1 SORL1	8.46e-05	9	54	2	20005821
Pubmed	Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.	ADAM19 LRP1 ARHGEF17	1.03e-04	58	54	3	23284291
Pubmed	Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development.	TENM4 TENM1	1.06e-04	10	54	2	38713721
Pubmed	The transcription factor GATA-6 regulates pathological cardiac hypertrophy.	GATA4 LRRCC1	1.06e-04	10	54	2	20705924
Pubmed	Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).	TRAF6 ARHGEF3 ARHGEF17	1.14e-04	60	54	3	12787561
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ATRN EGLN2 TRAF6 ADAM19 EHMT2 MIB1 LRP1 LRRCC1 PLAUR	1.48e-04	1285	54	9	35914814
Pubmed	Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin.	AKAP9 AKAP1	1.55e-04	12	54	2	17911601
Pubmed	Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance.	EHMT2 GATA4	1.55e-04	12	54	2	28949961
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	TENM4 LRP1 ARHGEF3	1.88e-04	71	54	3	33541421
Pubmed	Deficiency of Lipoprotein Lipase in Neurons Decreases AMPA Receptor Phosphorylation and Leads to Neurobehavioral Abnormalities in Mice.	LRP1 SORL1	2.80e-04	16	54	2	26263173
Pubmed	Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment.	EHMT2 GATA4	3.17e-04	17	54	2	20573702
Pubmed	An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.	TENM4 GATA4	3.56e-04	18	54	2	17350578
Pubmed	Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury.	EGLN2 NT5E	4.42e-04	20	54	2	21270129
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	ARHGEF28 MIB1 GATA4 ARHGEF3 ARHGEF17 AKAP1 SORL1	5.18e-04	916	54	7	32203420
Pubmed	Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models.	LRRK2 ATP2B4	5.36e-04	22	54	2	24427314
Pubmed	Ets1 is required for proper migration and differentiation of the cardiac neural crest.	ADAM19 GATA4	5.36e-04	22	54	2	20356956
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	ATRN SUSD2 LRP1 ADAMTS13	6.89e-04	257	54	4	16335952
Pubmed	Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation.	EHMT2 GATA4	7.51e-04	26	54	2	28087629
Pubmed	Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.	TRAF6 MIB1	8.72e-04	28	54	2	35474067
Pubmed	Biology, structure and mechanism of P-type ATPases.	ATP2B1 ATP2B4	9.35e-04	29	54	2	15071553
Pubmed	The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development.	ATP2B1 ATP2B4	1.00e-03	30	54	2	39366945
Pubmed	Embryonic forebrain transcriptome of mice with polyalanine expansion mutations in the ARX homeobox gene.	TENM1 SORL1	1.07e-03	31	54	2	27798109
Pubmed	GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.	ARHGEF3 ATP2B4	1.44e-03	36	54	2	23263863
Pubmed	The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.	GATA4 CTRL	1.44e-03	36	54	2	25063451
Cytoband	19q13.2	CAPN12 EGLN2 CD177	9.71e-04	164	54	3	19q13.2
Cytoband	5q13.2	CCDC125 ARHGEF28	1.94e-03	55	54	2	5q13.2
GeneFamily	ATPases Ca2+ transporting	ATP2B1 ATP2B4	1.38e-04	9	36	2	1209
GeneFamily	Zinc fingers MYND-type\|A-kinase anchoring proteins	AKAP9 AKAP1	1.51e-03	29	36	2	396
GeneFamily	CD molecules\|Complement system\|LY6/PLAUR domain containing	CD177 PLAUR	2.08e-03	34	36	2	1226
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETDB2 EHMT2	2.08e-03	34	36	2	487
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	FRMD4A MYO7B	4.45e-03	50	36	2	1293
GeneFamily	Proteases, serine	PRSS41 TMPRSS11B	6.98e-03	63	36	2	738
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	CD177 NT5E LRP1 PLAUR	7.54e-03	394	36	4	471
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF3 ARHGEF17	7.63e-03	66	36	2	722
Coexpression	HEVNER_CORTEX_APICAL_AND_BASAL_INTERMEDIATE_PROGENITOR_CELLS	FRMD4A MIB1 SEMA5A SORL1	5.07e-06	55	54	4	MM397
CoexpressionAtlas	dev gonad_e13.5_M_InterstitFLeydig_MafB_top-relative-expression-ranked_1000	SCUBE1 ADAM19 TENM4 NT5E GATA4 LRP1 SEMA5A PWWP3B ATP2B4 STC1	2.16e-05	773	54	10	gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_1000
CoexpressionAtlas	dev gonad_e13.5_M_InterstitFLeydig_MafB_top-relative-expression-ranked_200	SCUBE1 GATA4 LRP1 ATP2B4 STC1	3.46e-05	146	54	5	gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_200
CoexpressionAtlas	dev gonad_e13.5_M_InterstitTestis_Sma_top-relative-expression-ranked_200	SCUBE1 GATA4 LRP1 ATP2B4 STC1	3.57e-05	147	54	5	gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_200
CoexpressionAtlas	dev gonad_e12.5_M_InterstitTestis_Sma_top-relative-expression-ranked_200	SCUBE1 GATA4 LRP1 ATP2B4 STC1	4.33e-05	153	54	5	gudmap_dev gonad_e12.5_M_InterstitTestis_Sma_200
CoexpressionAtlas	DevelopingKidney_e15.5_cortic collect duct_emap-28132_top-relative-expression-ranked_500	AKAP9 MIB1 TENM1 SEMA5A ATP10B SORL1 STC1	5.63e-05	390	54	7	gudmap_developingKidney_e15.5_cortic collect duct_500
CoexpressionAtlas	Myeloid Cells, GN.BM, CD11b+ Ly6-G+, Bone marrow, avg-4	CCDC125 ATRN CD177 NT5E LRRK2 PLAUR SORL1	8.31e-05	415	54	7	GSM605846_500
CoexpressionAtlas	dev gonad_e12.5_M_InterstitLeydig_MafB_top-relative-expression-ranked_1000	SCUBE1 ADAM19 TENM4 GATA4 LRP1 SEMA5A PWWP3B ATP2B4 STC1	1.25e-04	768	54	9	gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_1000
CoexpressionAtlas	dev gonad_e12.5_M_InterstitTestis_Sma_top-relative-expression-ranked_1000	SCUBE1 ADAM19 TENM4 GATA4 LRP1 SEMA5A PWWP3B ATP2B4 STC1	1.59e-04	793	54	9	gudmap_dev gonad_e12.5_M_InterstitTestis_Sma_1000
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SCUBE1 ADAM19 SEMA5A LTBP2 AKAP1 STC1	1.25e-07	193	54	6	000b9e6a819b94ea2e6e9173daf97ba9ac2b6cc6
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Gkn1_Pcdh19\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SCUBE1 SUSD2 AMZ1 PLAUR ADAMTS13	8.73e-07	144	54	5	e8caeb6485f4c8f9a3384570dc69024c2bcc9ab0
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lsp1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ARHGEF28 NT5E SEMA5A LTBP2 STC1	1.42e-06	159	54	5	0dccc4275b9b4f8554dd556da7218e130bff8fd1
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TENM4 NT5E LTBP2 ATP2B1 STC1	3.87e-06	195	54	5	2414b158dc7bdec43a9671544bfb7ffc5f5168fd
ToppCell	droplet-Tongue-TONGUE\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGLN2 AKAP9 NT5E SEMA5A ATP2B1	3.96e-06	196	54	5	44a30b1a5f3d8c845e5f3bd17d8102a7449f555b
ToppCell	droplet-Tongue-TONGUE-1m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGLN2 AKAP9 NT5E SEMA5A ATP2B1	3.96e-06	196	54	5	9935bdb10789e8cfc922dca526ca3bf8317fe270
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EGLN2 AKAP9 NT5E SEMA5A ATP2B1	3.96e-06	196	54	5	a85f5f1e6acc798e9e02b1a21e0ffe87a323c333
ToppCell	droplet-Heart-HEART-1m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT16 LRP1 SEMA5A ARHGEF17 HACD1	3.96e-06	196	54	5	1eb14182ef26e6141f510d397b00bf8a12efda3e
ToppCell	P07-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TENM4 NT5E LTBP2 ATP2B1 STC1	3.96e-06	196	54	5	74093f85e095606d1c723e0d7c2d78d9cfa47c4f
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ARHGEF28 AKAP9 NT5E LRRK2 AKAP1	4.06e-06	197	54	5	1485933986921ff45669d9b7501c8d17050b3e97
ToppCell	control-Myeloid-Non-resident_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	LRRK2 LRP1 PLAUR ATP2B1 SORL1	4.06e-06	197	54	5	df2fe36cb96e2565a9d21c24cb4e451e8befd4be
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AMZ1 LRRK2 LRP1 SEMA5A ATP10B	4.27e-06	199	54	5	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	TCGA-Brain-Recurrent_Tumor-Glioblastoma-Primary_GBM\|TCGA-Brain / Sample_Type by Project: Shred V9	CD177 SUSD2 LTBP2 STC1	2.38e-05	138	54	4	728e0576526c4525ba2038921425ab3e7d321ce2
ToppCell	TCGA-Brain-Recurrent_Tumor-Glioblastoma\|TCGA-Brain / Sample_Type by Project: Shred V9	CD177 SUSD2 LTBP2 STC1	2.38e-05	138	54	4	142e4692d7f97ce157ed70fcb2e4a63febfbb6e4
ToppCell	facs-Heart-RV-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD177 AMZ1 PLAUR SORL1	4.04e-05	158	54	4	2a222301474c4dfd9a776e197c10f4c1cacceb62
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_IT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	AMZ1 PLAUR ADAMTS13 ATP2B4	4.04e-05	158	54	4	9e0589f770920f8ac41cfe5cd0a29e9e7a04a308
ToppCell	facs-Heart-RV-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD177 AMZ1 PLAUR SORL1	4.04e-05	158	54	4	ff9878fd768f22bf2ee4805bac2ba01cb3cb804a
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_ALM_Oprk1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	AMZ1 PLAUR ADAMTS13 ATP2B4	4.45e-05	162	54	4	2d28306c6125b31f11ea6d911a167b93a74907c5
ToppCell	CV-Mild-6\|CV / Virus stimulation, Condition and Cluster	CCDC125 CAPN12 CTRL SORL1	5.01e-05	167	54	4	cf2ed0b6d17a16f9a2318879ce8856d5983ad3cf
ToppCell	Influenza_Severe-Neutrophil\|World / Disease group and Cell class	CD177 MYO7B LRRK2 SORL1	5.25e-05	169	54	4	6e8e2580e19c96bcf7fa6a6d8c183df65f428396
ToppCell	facs-Marrow-T-cells-3m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRMD4A TENM4 ZC3H12C RSC1A1	5.49e-05	171	54	4	6a0fafb8fd9fc7671618eeb2bf528ce8ce86b794
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD177 LRRK2 PLAUR SORL1	5.49e-05	171	54	4	ab21f20ec041cbaacccbd7da4dccdb77ec8bc5c6
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD177 LRRK2 PLAUR SORL1	5.49e-05	171	54	4	97ad2cfff568a9d006ab1d2e6e00946ee4e3beb3
ToppCell	facs-Marrow-T-cells-3m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRMD4A TENM4 ZC3H12C RSC1A1	5.49e-05	171	54	4	e02b5831768dbb1b68998b672e55c9680ab0cc86
ToppCell	droplet-Marrow-nan-3m-Hematologic-proerythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD177 LRRK2 PLAUR SORL1	5.62e-05	172	54	4	cfcfa7eeff1805bedf10a3c07826459914c3e872
ToppCell	pdx-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	CCDC125 ATRN ARHGEF28 ARHGEF3	6.14e-05	176	54	4	1e21f80cf0e695ffdd63e4a72cf1e3fa41b60341
ToppCell	metastatic_Brain-Endothelial_cells-Lymphatic_ECs\|Endothelial_cells / Location, Cell class and cell subclass	LRP1 LRRCC1 HACD1 RSPRY1	6.14e-05	176	54	4	42541dfe20eb29625d47c0bb79bf3c21a2460340
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRN CD177 PLAUR SORL1	6.28e-05	177	54	4	065bebd22031f143e90a407f952b444a3f8818c7
ToppCell	E16.5-Immune-Immune_Myeloid-DC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AMZ1 LRRK2 ZC3H12C CTRL	6.28e-05	177	54	4	235254c08b44c20ee3cb62dd2ca0c7e46a2587e3
ToppCell	facs-Marrow-Granulocytes-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRN CD177 PLAUR SORL1	6.28e-05	177	54	4	eb304f20aab075bd17aa3aef819386c0e1a235bd
ToppCell	E16.5-Immune-Immune_Myeloid-DC-cDC2\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AMZ1 LRRK2 ZC3H12C CTRL	6.28e-05	177	54	4	b59d9fcf0a4964ef2d6274b6021a69cf7d335e0a
ToppCell	E16.5-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AMZ1 LRRK2 ZC3H12C CTRL	6.28e-05	177	54	4	f55332fe7fc32c23892ccf08b6b4d5b1ffcc0d3f
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGEF28 TENM4 LRRK2 AKAP1	6.56e-05	179	54	4	fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 MYO7B LRRK2 SEMA5A	6.56e-05	179	54	4	58ae5a97fe2a14e1c6fdeb886397eb06fdaf0428
ToppCell	Control-Myeloid-Dendritic_cells\|Control / group, cell type (main and fine annotations)	FRMD4A ADAM19 PLAUR ATP2B1	6.70e-05	180	54	4	25ad95c3c30e3b82abe93bd77ba003f5c2241f7c
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TENM1 SEMA5A ATP2B4 STC1	6.70e-05	180	54	4	b514c55e52b46e8a1a2f09ed2c59a7683367a505
ToppCell	AT1_cells-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	SCUBE1 RIMKLA SUSD2 SEMA5A	6.70e-05	180	54	4	ff4728782c3ec814ba071cc22b7894abdd9da837
ToppCell	COVID-19-kidney-Stressed_PCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ARHGEF28 MYO7B TENM1 PWWP3B	6.85e-05	181	54	4	6980ea624151da32b7f537f263e40fcb87a02e81
ToppCell	cellseq2-Immune-Hematopoietic-Granulocytic-Neutrophil\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CD177 MYO7B LRRK2 SORL1	7.00e-05	182	54	4	1932d77491d6d46278f01fd70eb469ef1b356619
ToppCell	cellseq2-Immune-Hematopoietic-Granulocytic\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CD177 MYO7B LRRK2 SORL1	7.15e-05	183	54	4	cfbf8539104cef9ca830ad4f6bb278746f7078f7
ToppCell	Control-Epithelial_cells-Airway_mucous\|Control / group, cell type (main and fine annotations)	ARHGEF28 MYO7B GATA4 ATP10B	7.15e-05	183	54	4	15d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCell	cellseq2-Immune-Hematopoietic\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CD177 MYO7B LRRK2 SORL1	7.15e-05	183	54	4	324ec4374b552da7ce03809945b3a0798342d4ba
ToppCell	LPS_only-Epithelial_alveolar-AT_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGEF28 TENM4 LRRK2 AKAP1	7.15e-05	183	54	4	e972432dd4d1bd31bb0982f4df3061e5e152658f
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGEF28 TENM4 NT5E AKAP1	7.30e-05	184	54	4	d0c212a8fbaad24597a84018442b25c61c17ea58
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGEF28 TENM4 LRRK2 AKAP1	7.30e-05	184	54	4	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	droplet-Liver-LIVER_HEP-30m-Mesenchymal\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 SCUBE1 ADAMTS13 ARHGEF17	7.45e-05	185	54	4	f814ec9d4ade717a0109398e9768d0d66f09317b
ToppCell	droplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 SCUBE1 ADAMTS13 ARHGEF17	7.45e-05	185	54	4	40e958511790e84321da5ccf735f9974c06a0263
ToppCell	droplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP47 SCUBE1 ADAMTS13 ARHGEF17	7.45e-05	185	54	4	5f2eeba80aff145e85cfd81e2890a155406badb9
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SCUBE1 ADAM19 LTBP2 STC1	7.45e-05	185	54	4	e58a009aaf342be019a909747b1895d5987d4daf
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 MYO7B LRRK2 SEMA5A	7.61e-05	186	54	4	f28d72b47624b69a580b4429e2be560a26898591
ToppCell	Anterior_Cingulate_gyrus_(CgG)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARHGEF28 TENM1 SEMA5A ATP2B4	7.61e-05	186	54	4	32af3f211f9ad5d5c6b86b83325cfbf2f8466b56
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGEF28 TENM4 LRRK2 AKAP1	7.61e-05	186	54	4	e83718fabb057100835d3357df407f283d23fe16
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADAM19 SEMA5A LTBP2 STC1	7.77e-05	187	54	4	387cb27c8a20031cd87381a9e1172f1f62e1488b
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CD177 LRRK2 PLAUR SORL1	7.77e-05	187	54	4	75bc05a0ba2727fecc236903ace792a28f3d3c9a
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_0\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CD177 LRRK2 PLAUR SORL1	7.77e-05	187	54	4	a0d59bf1043ff5a1e8110b39ecc2d3932675edd4
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CD177 LRRK2 PLAUR SORL1	7.93e-05	188	54	4	aa46073e2940dc1d2020b2e259bf0fc06cb990ee
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil-Neu_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CD177 LRRK2 PLAUR SORL1	7.93e-05	188	54	4	04814b78da936a51a497e23060d19ca0d619e250
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGEF28 TENM4 LRRK2 AKAP1	7.93e-05	188	54	4	4bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCell	AT1-AT2_cells-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	SCUBE1 RIMKLA SUSD2 SEMA5A	7.93e-05	188	54	4	be710bc957118cf426dd71c2d57e6f1b41c9a467
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SCUBE1 ADAM19 LTBP2 AKAP1	7.93e-05	188	54	4	f54b063025d80de631382bf5326bc40aab7f7d00
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRMD4A ARHGEF28 TENM4 AMZ1	7.93e-05	188	54	4	d7a9fb5b021e127b8d927658a55a71098d513b5c
ToppCell	kidney_cells-Hypertensive_with+without-CKD\|kidney_cells / Celltypes from Cells and Nuclei per compartment and clinical group	LRRK2 SEMA5A SORL1 STC1	7.93e-05	188	54	4	90188b60ff893754f7938fe8edab79758827168e
ToppCell	COVID-19_Severe-Myeloid_G-Neutrophil\|COVID-19_Severe / Disease group, lineage and cell class	CD177 LRRK2 PLAUR SORL1	8.10e-05	189	54	4	a62f4c445ede00d15b74bee65f4e4fb54cfd4d32
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CD177 LRRK2 PLAUR SORL1	8.10e-05	189	54	4	f6b2b4824505f0119a017fdb73c55418fb651645
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 MYO7B TENM1 SEMA5A	8.10e-05	189	54	4	204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCell	PBMC-Severe-Myeloid-Neutrophil-Neutrophil\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CD177 LRRK2 PLAUR SORL1	8.10e-05	189	54	4	db8e314ce95c32542bb4015a77032a33211fea0b
ToppCell	Non-neuronal-Non-dividing-OPC-OPC\|World / Primary Cells by Cluster	NT5E LRRK2 SEMA5A ATP10B	8.10e-05	189	54	4	ddf5be73912570c32c50f4ac2902da9b590526f8
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CCDC125 CFAP47 ARHGEF28 SORL1	8.10e-05	189	54	4	7659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CAPN12 MYO7B TENM1 SEMA5A	8.10e-05	189	54	4	13fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCell	Non-neuronal-Non-dividing-OPC\|World / Primary Cells by Cluster	NT5E LRRK2 SEMA5A ATP10B	8.10e-05	189	54	4	13848a031ab896b4b24c8319e4745b9b17ff9cfd
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ADAM19 LTBP2 AKAP1 STC1	8.10e-05	189	54	4	0abc7a4900cc9033bc1be69b770ccc54a6bf41b4
ToppCell	Non-neuronal-Non-dividing-OPC-OPC-30\|World / Primary Cells by Cluster	NT5E LRRK2 SEMA5A ATP10B	8.10e-05	189	54	4	313d165fad541ec6e8dd524b88856e2c93eeb681
ToppCell	PND10\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAM19 AKAP9 LTBP2 ATP2B1	8.26e-05	190	54	4	d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SCUBE1 ADAM19 LTBP2 AKAP1	8.26e-05	190	54	4	938d1f66094b1c94606e0d40213a39e5112f3322
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_monocytic-intermediate_monocyte\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CCDC125 CD177 PWWP3B ARHGEF17	8.26e-05	190	54	4	896b5825edb30fe62cbbed6078570c1f8057a99e
ToppCell	LAM-Epithelial-AT1\|LAM / Condition, Lineage and Cell class	SCUBE1 RIMKLA SUSD2 SEMA5A	8.43e-05	191	54	4	66875b2ec2c510489407f3e433a90cdf74a15094
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LRRK2 PLAUR ATP2B1 SORL1	8.43e-05	191	54	4	47156e5f1d790707f42f6283104a44b33af613e5
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW16-OPC_related-OPC\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	NT5E LRRK2 SEMA5A ATP10B	8.60e-05	192	54	4	5d9bc234f01c73b2531edf8960588d5b6cf260a7
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW16-OPC_related\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	NT5E LRRK2 SEMA5A ATP10B	8.60e-05	192	54	4	e6d115143ced6a0d9fe7c98acd3f730bac83f66b
ToppCell	AT1_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	SCUBE1 RIMKLA SUSD2 SEMA5A	8.60e-05	192	54	4	0444f9e9cef7403e220e862b5a787443d3f5c9ac
ToppCell	CTRL-Myeloid-Alveolar_Macrophage\|Myeloid / Disease state, Lineage and Cell class	FRMD4A ARHGEF28 LRP1 ARHGEF3	8.78e-05	193	54	4	80871d963c23a6befe58e5e60b7f7d1a1b227ce2
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	ADAM19 GATA4 ATP2B4 HACD1	8.78e-05	193	54	4	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	severe-Myeloid-Neutrophils_3\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	ADAM19 CD177 LRRK2 SORL1	8.78e-05	193	54	4	f4d43dfbf4115dd0f843ea5cf08049220342a047
ToppCell	LA\|World / Chamber and Cluster_Paper	FRMD4A ADAM19 LRP1 LTBP2	8.78e-05	193	54	4	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	B_cells-Activate_B_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	ADAM19 NT5E WNT16 ATP2B1	8.78e-05	193	54	4	b6da81920cf2e55f87ec8d4b2b5530cbf7ba2155
ToppCell	severe-Myeloid-Neutrophils_3\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	ADAM19 CD177 LRRK2 SORL1	8.95e-05	194	54	4	1f8edab1c8ba48bc0114429ea47aab378b5830b7
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LTBP2 ARHGEF17 ATP2B4 HACD1	8.95e-05	194	54	4	aaecde88bd54134a938e76cdf059c1c2653e4e77
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADAM19 SEMA5A LTBP2 STC1	8.95e-05	194	54	4	67f5e2f05a8de2213ab80d5ea16fdee121684633
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TENM4 LTBP2 ATP2B1 STC1	9.13e-05	195	54	4	b0d408f8bc1701a87596ed55efcd90749fee33e6
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TENM4 LTBP2 ATP2B1 STC1	9.13e-05	195	54	4	2514c1f23424b5fc664d326d31ffd22bafe74ef8
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRMD4A SETDB2 LRP1 PLAUR	9.13e-05	195	54	4	9d649ac7d2af313481069c95349efc0c68449e2b
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CD177 LRRK2 LRP1 PLAUR	9.13e-05	195	54	4	b0dbaae86f5703ab62f925e0f36500274044884a
ToppCell	myeloid-CD14+_Monocyte\|myeloid / Lineage and Cell class	LRRK2 LRP1 PLAUR ATP2B1	9.13e-05	195	54	4	60fab0c24c827567fb42bbd7eb165bf45178c198
ToppCell	AT1_cells\|World / lung cells shred on cell class, cell subclass, sample id	SCUBE1 RIMKLA SUSD2 SEMA5A	9.13e-05	195	54	4	792d6a49b0a875a00569071183d195287a9925c5
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TENM4 LTBP2 ATP2B1 STC1	9.13e-05	195	54	4	a486a7acea0e91048cc48afa0dbd3926d30bc217
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)\|Adult / Lineage, Cell type, age group and donor	FRMD4A LRP1 PLAUR ATP2B1	9.13e-05	195	54	4	55e25f702af19146a161861cfd15f40bbda1dc35
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LRRK2 PLAUR ATP2B1 SORL1	9.32e-05	196	54	4	fe8d3f45a64323947c36b127355d5940eb56c0ca
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TENM4 LTBP2 ATP2B1 STC1	9.32e-05	196	54	4	e4d04e1f82779e8afd4e32bbe38d1d3f6f64ab50
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TENM4 LTBP2 ATP2B1 STC1	9.32e-05	196	54	4	f0fd7db22985d2bc84dc8bcbdb2d552e280121dd
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SCUBE1 RIMKLA SUSD2 SEMA5A	9.32e-05	196	54	4	6731fef8c148b6681d6ed38afdf23c8213e0bbbe
Drug	caloxin 1b1	ATP2B1 ATP2B4	5.52e-06	2	54	2	ctd:C510327
Disease	galectin-4 measurement	CAPN12 ARHGEF3	1.89e-05	4	53	2	EFO_0020398
Disease	Hailey-Hailey disease (implicated_via_orthology)	ATP2B1 ATP2B4	4.73e-05	6	53	2	DOID:0050429 (implicated_via_orthology)
Disease	FEV/FEC ratio	FRMD4A ADAM19 ARHGEF28 AMZ1 WNT16 LRP1 LTBP2 ARHGEF17 ATP2B1 SORL1	5.73e-05	1228	53	10	EFO_0004713
Disease	pulmonary function measurement, smoking behaviour measurement, FEV/FEC ratio	ADAM19 LRP1 ARHGEF17	8.39e-05	47	53	3	EFO_0003892, EFO_0004713, EFO_0005671
Disease	smoking status measurement, systolic blood pressure	TENM4 EHMT2 GATA4 ATP2B1	1.80e-04	156	53	4	EFO_0006335, EFO_0006527
Disease	congenital diaphragmatic hernia (implicated_via_orthology)	GATA4 LRP1	2.07e-04	12	53	2	DOID:3827 (implicated_via_orthology)
Disease	chronic obstructive pulmonary disease	FRMD4A ADAM19 ARHGEF28 TENM4 EHMT2 AMZ1 ARHGEF17	2.21e-04	688	53	7	EFO_0000341
Disease	Colorectal Carcinoma	ADAM19 AKAP9 WNT16 TENM1 GATA4 LRP1 SORL1	2.49e-04	702	53	7	C0009402
Disease	platelet crit	CAPN12 AMZ1 LRRK2 PSMB7 PLAUR ARHGEF3 ATP2B4 SORL1	2.79e-04	952	53	8	EFO_0007985
Disease	Child Behaviour Checklist assessment	TENM4 STC1	4.75e-04	18	53	2	EFO_0005661
Disease	smoking status measurement, chronic obstructive pulmonary disease	ADAM19 EHMT2 AMZ1	5.39e-04	88	53	3	EFO_0000341, EFO_0006527
Disease	pulse pressure measurement, alcohol consumption measurement	GATA4 ATP2B1	7.15e-04	22	53	2	EFO_0005763, EFO_0007878
Disease	colorectal cancer, overall survival	ADAM19 SORL1	1.25e-03	29	53	2	EFO_0000638, MONDO_0005575
Disease	myeloid white cell count	CCDC125 AMZ1 PSMB7 PLAUR ARHGEF3 ATP2B4 SORL1	1.37e-03	937	53	7	EFO_0007988
Disease	spontaneous coronary artery dissection	LRP1 ATP2B1	1.42e-03	31	53	2	EFO_0010820
Disease	sleep apnea measurement, obstructive sleep apnea	NBAS ATP2B4	1.61e-03	33	53	2	EFO_0003918, EFO_0007817

Protein segments in the cluster

Peptide	Gene	Start	Entry
TDSMICAGGAGASSC	CTRL	196	P40313
GGSDRNSMDSVDSCC	AKAP1	571	Q92667
ADDCSSEVNGCSFVM	AKAP9	111	Q99996
CERMEQTDSSCGNSR	ARHGEF3	506	Q9NR81
AMSCSENCSSAQGDS	APLF	321	Q8IW19
ASADSGMCCESDSEP	AMZ1	346	Q400G9
GMCCESDSEPGTSVS	AMZ1	351	Q400G9
CSASAADGGCIMAAA	ADAM19	361	Q9H013
CMATESVDGELSGCN	EHMT2	446	Q96KQ7
NTSCDSGLGCQDTLM	CD177	46	Q8N6Q3
DACETMGNATAICSD	ATP2B1	461	P20020
DACETMGNATAICSD	ATP2B4	451	P23634
ECMRDDSCSGDSSAQ	ATP10B	1406	O94823
SCRTFGCDGRMDSQQ	ADAMTS13	526	Q76LX8
CSTDGRMQSNCSLGG	RIMKLA	216	Q8IXN7
CCGAGTAADTDMTTQ	PSMB7	86	Q99436
SQMGAVSQSCEDSCG	ARHGEF28	1291	Q8N1W1
GQDSSRCVACMVDSS	ARHGEF17	1856	Q96PE2
SSSLRCNMFDDCGDG	LRP1	3756	Q07954
RTACGDCTSGSSECM	ATRN	936	O75882
MASGSCQGCEEDEET	LRRK2	1	Q5S007
EDSCGKMDACGSASR	TUBGCP6	986	Q96RT7
GEANAMCLATCTRDG	PNPO	76	Q9NVS9
CETAEVGMSKASSCG	NBAS	256	A2RRP1
DSSPSMSGCCGEDCS	NAA40	196	Q86UY6
IMCCGGKSSEDATDD	MIB1	911	Q86YT6
SMFCAGAEDGSVDTC	PRSS41	231	Q7RTY9
SSEAGMNAICSSAGC	NPC1L1	911	Q9UHC9
RSSNGSDPMDDCSSC	FRMD4A	736	Q9P2Q2
FSEGRECVNCGAMST	GATA4	211	P43694
DMSRTDVCQGSLGNC	CAPN12	91	Q6ZSI9
ENMCCDKSGFAEASG	CCDC125	256	Q86Z20
CAATMASSDEDGTNG	HACD1	36	B0YJ81
TMCGSHGFCDNTDGS	LTBP2	1311	Q14767
NQEAEREGGMSCSCS	EGLN2	141	Q96KS0
REGGMSCSCSSGSGE	EGLN2	146	Q96KS0
SSECSGCSNSETFME	RSC1A1	236	Q92681
GTTHCGDVDECSMSN	SCUBE1	356	Q8IWY4
GDVDECSMSNGSCDQ	SCUBE1	361	Q8IWY4
DDMSSSGSDTDQGCS	CFAP47	2036	Q6ZTR5
DAQESCSMRCGALDG	SUSD2	26	Q9UGT4
NDCGDMSDERNCPTT	SORL1	1101	Q92673
AATTMGNSCICRDDS	RSPRY1	36	Q96DX4
ESEMGAAACPGSCSR	PWWP3B	301	Q5H9M0
TGSDCSTELCTMECG	TENM1	686	Q9UKZ4
EMRYCSSDGTSGCST	SEMA5A	751	Q13591
AFACLENSTCDTDGM	STC1	56	P52823
EDSSKCVNASRCMGG	NT5E	46	P21589
SSMFTDSCDCSEGCI	SETDB2	286	Q96T68
ECISCGSSDMSCERG	PLAUR	116	Q03405
CAGFMSGEADACQND	TMPRSS11B	351	Q86T26
GSSQSESDCCVAMAS	TRAF6	11	Q9Y4K3
RGAGCDTSMETACGD	TENM4	826	Q6N022
TRSCSAGNMTECSCD	WNT16	136	Q9UBV4
SVASDCSSEGSMSCG	ZC3H12C	621	Q9C0D7
NEDGDSSCGDVCFMD	LRRCC1	16	Q9C099
LTMGNCTSCEGLNDA	MYO7B	281	Q6PIF6