Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH17 DNAH9 DNAH11	2.36e-05	18	63	3	GO:0008569
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH17 DNAH9 DNAH11	9.27e-05	28	63	3	GO:0051959
GeneOntologyMolecularFunction	kinase activity	BMPR1B MAPK14 PIK3C2G SGK1 NEK7 CARD11 DGKH MAPK3 NEK11 EPHA8	1.29e-04	764	63	10	GO:0016301
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNAH17 DNAH9 DNAH11	2.15e-04	37	63	3	GO:0045505
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	BMPR1B MAPK14 PIK3C2G SGK1 NEK7 DGKH MAPK3 NEK11 EPHA8	3.63e-04	709	63	9	GO:0016773
GeneOntologyMolecularFunction	protein domain specific binding	DOCK3 SCAF1 TRAF4 DLC1 ATN1 PKD1 SHC4 CARD11 DGKH PMEPA1	3.84e-04	875	63	10	GO:0019904
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	BMPR1B MAPK14 PIK3C2G SGK1 NEK7 CARD11 DGKH MAPK3 NEK11 EPHA8	6.62e-04	938	63	10	GO:0016772
GeneOntologyMolecularFunction	MAP kinase activity	MAPK14 MAPK3	1.14e-03	16	63	2	GO:0004707
GeneOntologyMolecularFunction	microtubule motor activity	DNAH17 DNAH9 DNAH11	1.41e-03	70	63	3	GO:0003777
Domain	DHC_N1	DNAH9 DNAH11	2.90e-04	8	61	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH9 DNAH11	2.90e-04	8	61	2	IPR013594
Domain	zf-TRAF	TRAF4 PDZRN3	2.90e-04	8	61	2	PF02176
Domain	Kinase-like_dom	BMPR1B MAPK14 PIK3C2G SGK1 NEK7 MAPK3 NEK11 EPHA8	3.64e-04	542	61	8	IPR011009
Domain	MAP_kinase_CS	MAPK14 MAPK3	6.78e-04	12	61	2	IPR003527
Domain	Znf_TRAF	TRAF4 PDZRN3	6.78e-04	12	61	2	IPR001293
Domain	MAPK	MAPK14 MAPK3	6.78e-04	12	61	2	PS01351
Domain	PROTEIN_KINASE_ATP	BMPR1B MAPK14 SGK1 NEK7 MAPK3 NEK11 EPHA8	7.18e-04	459	61	7	PS00107
Domain	ZF_TRAF	TRAF4 PDZRN3	8.00e-04	13	61	2	PS50145
Domain	Dynein_heavy_chain_D4_dom	DNAH9 DNAH11	9.31e-04	14	61	2	IPR024317
Domain	Dynein_HC_stalk	DNAH9 DNAH11	9.31e-04	14	61	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH9 DNAH11	9.31e-04	14	61	2	IPR013602
Domain	DHC_N2	DNAH9 DNAH11	9.31e-04	14	61	2	PF08393
Domain	MT	DNAH9 DNAH11	9.31e-04	14	61	2	PF12777
Domain	AAA_8	DNAH9 DNAH11	9.31e-04	14	61	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH9 DNAH11	9.31e-04	14	61	2	IPR011704
Domain	-	TRAF4 PDZRN3	9.31e-04	14	61	2	3.90.890.10
Domain	AAA_5	DNAH9 DNAH11	9.31e-04	14	61	2	PF07728
Domain	Prot_kinase_dom	BMPR1B MAPK14 SGK1 NEK7 MAPK3 NEK11 EPHA8	1.04e-03	489	61	7	IPR000719
Domain	Ser/Thr_kinase_AS	BMPR1B MAPK14 SGK1 NEK7 MAPK3 NEK11	1.07e-03	357	61	6	IPR008271
Domain	DHC_fam	DNAH9 DNAH11	1.07e-03	15	61	2	IPR026983
Domain	Dynein_heavy_dom	DNAH9 DNAH11	1.07e-03	15	61	2	IPR004273
Domain	Dynein_heavy	DNAH9 DNAH11	1.07e-03	15	61	2	PF03028
Domain	PROTEIN_KINASE_DOM	BMPR1B MAPK14 SGK1 NEK7 MAPK3 NEK11 EPHA8	1.09e-03	493	61	7	PS50011
Domain	S_TKc	BMPR1B MAPK14 SGK1 NEK7 MAPK3 NEK11	1.10e-03	359	61	6	SM00220
Domain	PROTEIN_KINASE_ST	BMPR1B MAPK14 SGK1 NEK7 MAPK3 NEK11	1.15e-03	362	61	6	PS00108
Domain	SIAH-type	TRAF4 PDZRN3	1.22e-03	16	61	2	IPR013323
Domain	Protein_kinase_ATP_BS	BMPR1B MAPK14 SGK1 NEK7 MAPK3 EPHA8	1.45e-03	379	61	6	IPR017441
Domain	Pkinase	BMPR1B MAPK14 SGK1 NEK7 MAPK3 NEK11	1.49e-03	381	61	6	PF00069
Domain	PLAT	DENND5B PKD1	2.12e-03	21	61	2	PS50095
Domain	-	DENND5B PKD1	2.12e-03	21	61	2	2.60.60.20
Domain	PLAT	DENND5B PKD1	2.12e-03	21	61	2	PF01477
Domain	PLAT/LH2_dom	DENND5B PKD1	2.12e-03	21	61	2	IPR001024
Domain	TRAF-like	TRAF4 PDZRN3	2.77e-03	24	61	2	IPR008974
Domain	SAM	DLC1 DGKH EPHA8	2.99e-03	88	61	3	SM00454
Domain	SAM_DOMAIN	DLC1 DGKH EPHA8	3.71e-03	95	61	3	PS50105
Domain	SAM	DLC1 DGKH EPHA8	3.93e-03	97	61	3	IPR001660
Domain	SAM/pointed	DLC1 DGKH EPHA8	6.62e-03	117	61	3	IPR013761
Domain	SAM_2	DLC1 DGKH	8.69e-03	43	61	2	PF07647
Domain	C2	C2CD3 PIK3C2G FER1L6	9.03e-03	131	61	3	PF00168
Pathway	WP_FOLLICLE_STIMULATING_HORMONE_FSH_SIGNALING	MAPK14 SGK1 MAPK3	7.88e-05	27	44	3	M39609
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH17 DNAH9 DNAH11	7.88e-05	27	44	3	M47755
Pathway	REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION	MAPK14 SGK1 MAPK3	7.88e-05	27	44	3	MM14779
Pathway	PID_REG_GR_PATHWAY	MAPK14 SGK1 FGG MAPK3	1.21e-04	82	44	4	M115
Pathway	KEGG_MEDICUS_PATHOGEN_SHIGELLA_OSPF_TO_TLR2_4_MAPK_SIGNALING_PATHWAY	MAPK14 MAPK3	1.42e-04	6	44	2	M47766
Pathway	BIOCARTA_FMLP_PATHWAY	MAPK14 PIK3C2G MAPK3	1.59e-04	34	44	3	M10287
Pathway	BIOCARTA_FMLP_PATHWAY	MAPK14 PIK3C2G MAPK3	1.59e-04	34	44	3	MM1399
Pathway	WP_TNFRELATED_WEAK_INDUCER_OF_APOPTOSIS_TWEAK_SIGNALING	MAPK14 RELB MAPK3	2.99e-04	42	44	3	M39452
Pathway	KEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT	DNAH17 DNAH9 DNAH11	3.21e-04	43	44	3	M47669
Pathway	BIOCARTA_DSP_PATHWAY	MAPK14 MAPK3	3.38e-04	9	44	2	M22032
Pathway	BIOCARTA_DSP_PATHWAY	MAPK14 MAPK3	3.38e-04	9	44	2	MM1554
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH17 DNAH9 DNAH11	3.67e-04	45	44	3	M47670
Pathway	WP_THYMIC_STROMAL_LYMPHOPOIETIN_TSLP_SIGNALING	MAPK14 RELB MAPK3	4.18e-04	47	44	3	M39380
Pathway	REACTOME_ACTIVATION_OF_THE_AP_1_FAMILY_OF_TRANSCRIPTION_FACTORS	MAPK14 MAPK3	4.22e-04	10	44	2	MM15135
Pathway	REACTOME_ACTIVATION_OF_THE_AP_1_FAMILY_OF_TRANSCRIPTION_FACTORS	MAPK14 MAPK3	4.22e-04	10	44	2	M13962
Pathway	WP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES	BMPR1B MAPK14 PIK3C2G MAPK3	4.89e-04	118	44	4	M39852
Pathway	WP_RANKLRANK_SIGNALING	MAPK14 RELB MAPK3	6.65e-04	55	44	3	M39667
Pubmed	Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.	DNAH17 DNAH9 DNAH11	2.17e-07	7	65	3	31178125
Pubmed	Suppression of HIV-1 Tat-induced monocyte adhesiveness by a cell-permeable superoxide dismutase in astrocytes.	MAPK14 MAPK3 SOD2	1.35e-06	12	65	3	18160848
Pubmed	Cell growth of ovarian cancer cells is stimulated by xenoestrogens through an estrogen-dependent pathway, but their stimulation of cell growth appears not to be involved in the activation of the mitogen-activated protein kinases ERK-1 and p38.	MAPK14 MAPK3	3.44e-06	2	65	2	18854640
Pubmed	Combined action of extracellular signal-regulated kinase and p38 kinase rescues Molt4 T cells from nitric oxide-induced apoptotic and necrotic cell death.	MAPK14 MAPK3	3.44e-06	2	65	2	15256218
Pubmed	Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase.	MAPK14 MAPK3	3.44e-06	2	65	2	11238443
Pubmed	Spatial and temporal expression of the myometrial mitogen-activated protein kinases p38 and ERK1/2 in the human uterus during pregnancy and labor.	MAPK14 MAPK3	3.44e-06	2	65	2	15784503
Pubmed	ERK and p38 MAPK signaling pathways negatively regulate CIITA gene expression in dendritic cells and macrophages.	MAPK14 MAPK3	3.44e-06	2	65	2	16785500
Pubmed	Nogo-A couples with Apg-1 through interaction and co-ordinate expression under hypoxic and oxidative stress.	HSPA4L RTN4	3.44e-06	2	65	2	23909438
Pubmed	Macropinocytosis and TAK1 mediate anti-inflammatory to pro-inflammatory macrophage differentiation by HIV-1 Nef.	IL32 MAPK14 MAPK3	4.98e-06	18	65	3	24874739
Pubmed	The Macrophage Activation Induced by Bacillus thuringiensis Cry1Ac Protoxin Involves ERK1/2 and p38 Pathways and the Interaction with Cell-Surface-HSP70.	MAPK14 MAPK3	1.03e-05	3	65	2	28608568
Pubmed	p38 and p42/44 MAPKs differentially regulate progesterone receptor A and B isoform stabilization.	MAPK14 MAPK3	1.03e-05	3	65	2	21816898
Pubmed	ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts.	MAPK14 MAPK3	1.03e-05	3	65	2	20155832
Pubmed	Potassium supplementation inhibits IL-17A production induced by salt loading in human T lymphocytes via p38/MAPK-SGK1 pathway.	MAPK14 SGK1	1.03e-05	3	65	2	27020669
Pubmed	Differentiation of human rhabdomyosarcoma RD cells is regulated by reciprocal, functional interactions between myostatin, p38 and extracellular regulated kinase signalling pathways.	MAPK14 MAPK3	1.03e-05	3	65	2	21273059
Pubmed	Shock wave treatment enhances cell proliferation and improves wound healing by ATP release-coupled extracellular signal-regulated kinase (ERK) activation.	MAPK14 MAPK3	1.03e-05	3	65	2	25118288
Pubmed	Hydrostatic pressures promote initial osteodifferentiation with ERK1/2 not p38 MAPK signaling involved.	MAPK14 MAPK3	1.03e-05	3	65	2	19259952
Pubmed	Interleukin-32 induces the differentiation of monocytes into macrophage-like cells.	IL32 MAPK14	1.03e-05	3	65	2	18296636
Pubmed	Antithrombin III suppresses ADP-induced platelet granule secretion: inhibition of HSP27 phosphorylation.	MAPK14 MAPK3	1.03e-05	3	65	2	19631608
Pubmed	Insulin-like growth factors inhibit dendritic cell-mediated anti-tumor immunity through regulating ERK1/2 phosphorylation and p38 dephosphorylation.	MAPK14 MAPK3	1.03e-05	3	65	2	25592043
Pubmed	Bisphosphonate- and statin-induced enhancement of OPG expression and inhibition of CD9, M-CSF, and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2.	MAPK14 MAPK3	1.03e-05	3	65	2	22579611
Pubmed	Leishmania initially activates but subsequently down-regulates intracellular mitogen-activated protein kinases and nuclear factor-kappaB signaling in macrophages.	MAPK14 MAPK3	1.03e-05	3	65	2	18406464
Pubmed	Eosinophil migration induced by mast cell chymase is mediated by extracellular signal-regulated kinase pathway.	MAPK14 MAPK3	1.03e-05	3	65	2	15919053
Pubmed	Inhibition of ERK and activation of p38 are involved in diallyl disulfide induced apoptosis of leukemia HL-60 cells.	MAPK14 MAPK3	1.03e-05	3	65	2	18563362
Pubmed	Expression of extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinase in the invasive trophoblasts at the human placental bed.	MAPK14 MAPK3	1.03e-05	3	65	2	18358530
Pubmed	Acute cutaneous barrier disruption activates epidermal p44/42 and p38 mitogen-activated protein kinases in human and hairless guinea pig skin.	MAPK14 MAPK3	1.03e-05	3	65	2	14714552
Pubmed	Differential roles of MAPK-Erk1/2 and MAPK-p38 in insulin or insulin-like growth factor-I (IGF-I) signaling pathways for progesterone production in human ovarian cells.	MAPK14 MAPK3	1.03e-05	3	65	2	21448845
Pubmed	RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells.	RELB SOD2	1.03e-05	3	65	2	28108513
Pubmed	Cilostazol protects endothelial cells against lipopolysaccharide-induced apoptosis through ERK1/2- and P38 MAPK-dependent pathways.	MAPK14 MAPK3	1.03e-05	3	65	2	19543489
Pubmed	Hepatic serum- and glucocorticoid-regulated protein kinase 1 (SGK1) regulates insulin sensitivity in mice via extracellular-signal-regulated kinase 1/2 (ERK1/2).	SGK1 MAPK3	1.03e-05	3	65	2	25222560
Pubmed	hNUDC promotes the cell proliferation and differentiation in a leukemic cell line via activation of the thrombopoietin receptor (Mpl).	MAPK14 MAPK3	1.03e-05	3	65	2	18288130
Pubmed	Induction of glucose metabolism in stimulated T lymphocytes is regulated by mitogen-activated protein kinase signaling.	MAPK14 MAPK3	1.03e-05	3	65	2	21085672
Pubmed	Myocardial protection evoked by hyperoxic exposure involves signaling through nitric oxide and mitogen activated protein kinases.	MAPK14 MAPK3	1.03e-05	3	65	2	17268885
Pubmed	Role of MAPK ERK1/2 and p38 in the Regulation of Secretory Functions of Different Populations of Neuroglia in Ethanol-Induced Neurodegeneration.	MAPK14 MAPK3	1.03e-05	3	65	2	34709510
Pubmed	Identification of extracellular signal-regulated kinase 1/2 and p38 MAPK as regulators of human sperm motility and acrosome reaction and as predictors of poor spermatozoan quality.	MAPK14 MAPK3	1.03e-05	3	65	2	18372245
Pubmed	ERK1/2 inactivation and p38 MAPK-dependent caspase activation during guanosine 5'-triphosphate-mediated terminal erythroid differentiation of K562 cells.	MAPK14 MAPK3	1.03e-05	3	65	2	17543571
Pubmed	Oxidants inhibit ERK/MAPK and prevent its ability to delay neutrophil apoptosis downstream of mitochondrial changes and at the level of XIAP.	MAPK14 MAPK3	1.03e-05	3	65	2	15292176
Pubmed	Hypoxia induces apoptosis of HUVECs in an in vitro capillary model by activating proapoptotic signal p38 through suppression of ERK1/2.	MAPK14 MAPK3	1.03e-05	3	65	2	17303382
Pubmed	An ERK-p38 subnetwork coordinates host cell apoptosis and necrosis during coxsackievirus B3 infection.	MAPK14 MAPK3	1.03e-05	3	65	2	23332156
Pubmed	Puerarin inhibits angiotensin II-induced cardiac hypertrophy via the redox-sensitive ERK1/2, p38 and NF-κB pathways.	MAPK14 MAPK3	1.03e-05	3	65	2	24608673
Pubmed	p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: evidence of cross-talk activation between MAP kinase cascades.	MAPK14 MAPK3	1.03e-05	3	65	2	12663671
Pubmed	Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake.	MAPK14 MAPK3	1.03e-05	3	65	2	20738258
Pubmed	A potential role of connexin 43 in epidermal growth factor-induced proliferation of mouse embryonic stem cells: involvement of Ca2+/PKC, p44/42 and p38 MAPKs pathways.	MAPK14 MAPK3	1.03e-05	3	65	2	18823499
Pubmed	The mitogen-activated protein (MAP) kinases p38 and extracellular signal-regulated kinase (ERK) are involved in hepatocyte-mediated phenotypic switching in prostate cancer cells.	MAPK14 MAPK3	1.03e-05	3	65	2	24619413
Pubmed	Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation.	BMPR1B MAPK14 MAPK3	1.57e-05	26	65	3	12805214
Pubmed	ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice.	PKD1 MAPK3	2.06e-05	4	65	2	19766642
Pubmed	Biological and prognostic relevance of mitogen-activated protein kinases in pancreatic adenocarcinoma.	MAPK14 MAPK3	2.06e-05	4	65	2	22158075
Pubmed	Beta-endorphin regulation of MAPKs in cultured human articular chondrocytes: MAPK inhibitors prevent the increase of IL-1 beta protein levels during beta-endorphin stimulation.	MAPK14 MAPK3	2.06e-05	4	65	2	17453826
Pubmed	Leptin signaling in neurotensin neurons involves STAT, MAP kinases ERK1/2, and p38 through c-Fos and ATF1.	MAPK14 MAPK3	2.06e-05	4	65	2	17077290
Pubmed	Benzo[a]pyrene-induced cell cycle progression is through ERKs/cyclin D1 pathway and requires the activation of JNKs and p38 mapk in human diploid lung fibroblasts.	MAPK14 MAPK3	2.06e-05	4	65	2	16699726
Pubmed	DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs.	MAPK14 MAPK3	2.06e-05	4	65	2	20347885
Pubmed	Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages.	MAPK14 MAPK3	2.06e-05	4	65	2	17463321
Pubmed	MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases.	MAPK14 MAPK3	2.06e-05	4	65	2	10597297
Pubmed	Acute ethanol exposure inhibits macrophage IL-6 production: role of p38 and ERK1/2 MAPK.	MAPK14 MAPK3	2.06e-05	4	65	2	14634061
Pubmed	Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses.	MAPK14 MAPK3	2.06e-05	4	65	2	15107845
Pubmed	Role of PI3K, MAPK/ERK 1/2, and p38 in Production of Erythropoietic Activity by Bone Marrow Cells after Blood Loss.	MAPK14 MAPK3	2.06e-05	4	65	2	27878722
Pubmed	Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.	MAPK14 MAPK3	2.06e-05	4	65	2	15964803
Pubmed	LCPTP-MAP kinase interaction: permanent partners or transient associates?	MAPK14 MAPK3	2.06e-05	4	65	2	12413699
Pubmed	Immune profiling of human prostate epithelial cells determined by expression of p38/TRAF-6/ERK MAP kinases pathways.	MAPK14 MAPK3	2.06e-05	4	65	2	29475459
Pubmed	Components of the mitogen-activated protein kinase cascade are activated in hepatic cells by Echinococcus multilocularis metacestode.	MAPK14 MAPK3	2.06e-05	4	65	2	19418584
Pubmed	Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.	MAPK14 MAPK3	2.06e-05	4	65	2	15537893
Pubmed	Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response.	MAPK14 MAPK3	2.06e-05	4	65	2	15851690
Pubmed	Glial cell-derived neurotrophic factor (GDNF) promotes low-grade Hs683 glioma cell migration through JNK, ERK-1/2 and p38 MAPK signaling pathways.	MAPK14 MAPK3	2.06e-05	4	65	2	16814421
Pubmed	High salt primes a specific activation state of macrophages, M(Na).	MAPK14 MAPK3	2.06e-05	4	65	2	26206316
Pubmed	Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase.	MAPK14 MAPK3	2.06e-05	4	65	2	10559944
Pubmed	Essential role for ERK2 mitogen-activated protein kinase in placental development.	MAPK14 MAPK3	2.06e-05	4	65	2	14622137
Pubmed	IL-17A contributes to myocardial ischemic injury by activating NLRP3 inflammasome in macrophages through AMPKα/p38MAPK/ERK1/2 signal pathway in mice.	MAPK14 MAPK3	2.06e-05	4	65	2	30562644
Pubmed	Overexpression of IL-32alpha increases natural killer cell-mediated killing through up-regulation of Fas and UL16-binding protein 2 (ULBP2) expression in human chronic myeloid leukemia cells.	IL32 MAPK14	2.06e-05	4	65	2	21321117
Pubmed	MECP2 promotes cell proliferation by activating ERK1/2 and inhibiting p38 activity in human hepatocellular carcinoma HEPG2 cells.	MAPK14 MAPK3	2.06e-05	4	65	2	24199952
Pubmed	Thiazolidinediones induce osteocyte apoptosis by a G protein-coupled receptor 40-dependent mechanism.	MAPK14 MAPK3	2.06e-05	4	65	2	22593579
Pubmed	Expressions and Regulatory Effects of P38/ERK/JNK Mapks in the Adipogenic Trans-Differentiation of C2C12 Myoblasts.	MAPK14 MAPK3	2.06e-05	4	65	2	29268268
Pubmed	Negative regulation of the serine/threonine kinase B-Raf by Akt.	SGK1 MAPK3	2.06e-05	4	65	2	10869359
Pubmed	Crucial implication of protein kinase C (PKC)-delta, PKC-zeta, ERK-1/2, and p38 MAPK in migration of human asthmatic eosinophils.	MAPK14 MAPK3	2.06e-05	4	65	2	19164129
Pubmed	Clustering of Genetic Anomalies of Cilia Outer Dynein Arm and Central Apparatus in Patients with Transposition of the Great Arteries.	DNAH9 DNAH11	2.06e-05	4	65	2	36140829
Pubmed	Fractalkine increases mesangial cell proliferation through reactive oxygen species and mitogen-activated protein kinases.	MAPK14 MAPK3	2.06e-05	4	65	2	22564616
Pubmed	Substance P enhances NF-kappaB transactivation and chemokine response in murine macrophages via ERK1/2 and p38 MAPK signaling pathways.	MAPK14 MAPK3	2.06e-05	4	65	2	18434625
Pubmed	Hypoxia activates beta(1)-integrin via ERK 1/2 and p38 MAP kinase in human vascular smooth muscle cells.	MAPK14 MAPK3	2.06e-05	4	65	2	12200131
Pubmed	Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice.	MAPK14 MAPK3	2.06e-05	4	65	2	19661066
Pubmed	Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP).	MAPK14 MAPK3	2.06e-05	4	65	2	10206983
Pubmed	The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation.	MAPK14 MAPK3	2.06e-05	4	65	2	28420753
Pubmed	Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways.	MAPK14 MAPK3	2.06e-05	4	65	2	21908610
Pubmed	Reactive oxygen species-activated p38/ERK 1/2 MAPK signaling pathway in the Mycobacterium bovis bacillus Calmette Guérin (BCG)-induced CCL2 secretion in human monocytic cell line THP-1.	MAPK14 MAPK3	2.06e-05	4	65	2	21199725
Pubmed	Activation of stress kinases in the brain of mucopolysaccharidosis IIIB mice.	MAPK14 MAPK3	2.06e-05	4	65	2	21618584
Pubmed	Possible role of p38 MAPK-MNK1-EMI2 cascade in metaphase-II arrest of mouse oocytes.	MAPK14 MAPK3	2.06e-05	4	65	2	24920040
Pubmed	HB-EGF synthesis and release induced by cholesterol depletion of human epidermal keratinocytes is controlled by extracellular ATP and involves both p38 and ERK1/2 signaling pathways.	MAPK14 MAPK3	2.06e-05	4	65	2	21413023
Pubmed	Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically.	MAPK14 MAPK3	2.06e-05	4	65	2	11387337
Pubmed	Connexin 43 promotes ossification of the posterior longitudinal ligament through activation of the ERK1/2 and p38 MAPK pathways.	MAPK14 MAPK3	2.06e-05	4	65	2	26334722
Pubmed	Betuletol 3-methyl ether induces G(2)-M phase arrest and activates the sphingomyelin and MAPK pathways in human leukemia cells.	MAPK14 MAPK3	2.06e-05	4	65	2	19676104
Pubmed	Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells.	MAPK14 MAPK3	2.06e-05	4	65	2	19723095
Pubmed	Mechanical regulation of cancer cell apoptosis and autophagy: roles of bone morphogenetic protein receptor, Smad1/5, and p38 MAPK.	BMPR1B MAPK14	2.06e-05	4	65	2	24021264
Pubmed	TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis.	MAPK14 RELB MAPK3	2.44e-05	30	65	3	25063677
Pubmed	Enhanced p22phox expression impairs vascular function through p38 and ERK1/2 MAP kinase-dependent mechanisms in type 2 diabetic mice.	MAPK14 MAPK3	3.43e-05	5	65	2	24486509
Pubmed	Immunomodulatory effect of water extract of cinnamon on anti-CD3-induced cytokine responses and p38, JNK, ERK1/2, and STAT4 activation.	MAPK14 MAPK3	3.43e-05	5	65	2	22053946
Pubmed	Cadmium induces mucin 8 expression via Toll-like receptor 4-mediated extracellular signal related kinase 1/2 and p38 mitogen-activated protein kinase in human airway epithelial cells.	MAPK14 MAPK3	3.43e-05	5	65	2	26782637
Pubmed	Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the phosphatidylinositol 3-kinase, p38 MAPK, and ERK1/2 pathways and not by the toll-like receptor-MyD88 pathway.	MAPK14 MAPK3	3.43e-05	5	65	2	18703508
Pubmed	Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation.	PDHA1 MAPK3	3.43e-05	5	65	2	21852536
Pubmed	Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase.	MAPK14 MAPK3	3.43e-05	5	65	2	10415025
Pubmed	Signalling pathway involving GULP, MAPK and Rac1 for SR-BI-induced phagocytosis of apoptotic cells.	MAPK14 MAPK3	3.43e-05	5	65	2	19122200
Pubmed	RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK).	MAPK14 MAPK3	3.43e-05	5	65	2	9792677
Pubmed	Arachidonic acid release by H2O2 mediated proliferation of mouse embryonic stem cells: involvement of Ca2+/PKC and MAPKs-induced EGFR transactivation.	MAPK14 MAPK3	3.43e-05	5	65	2	19199341
Pubmed	Epidermal growth factor-stimulated extravillous cytotrophoblast motility is mediated by the activation of PI3-K, Akt and both p38 and p42/44 mitogen-activated protein kinases.	MAPK14 MAPK3	3.43e-05	5	65	2	18487214
Cytoband	4q28	HSPA4L FGG	7.06e-05	9	65	2	4q28
Cytoband	3p21.2	DOCK3 RBM15B	3.32e-04	19	65	2	3p21.2
GeneFamily	Dyneins, axonemal	DNAH17 DNAH9 DNAH11	8.93e-06	17	44	3	536
GeneFamily	Mitogen-activated protein kinases	MAPK14 MAPK3	4.44e-04	13	44	2	651
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND5B SMCR8	1.68e-03	25	44	2	504
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	PKD1 FREM1	4.47e-03	41	44	2	1298
GeneFamily	Short chain dehydrogenase/reductase superfamily	HSD3B7 HSDL2	1.47e-02	76	44	2	743
GeneFamily	Sterile alpha motif domain containing	DGKH EPHA8	1.94e-02	88	44	2	760
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Macroglial-Glia_progenitor_cell\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	DLC1 PIK3C2G SGK1 RECQL5 PLEKHB1 MSTO1	4.33e-07	200	64	6	6c1b7b0f3cd35d8cfee181ea83c73127dbc41ac5
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MS4A8 DGKH DNAH9 NEK11 DNAH11	4.49e-06	169	64	5	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B PIK3C2G CAMSAP2 FREM1 FER1L6	5.47e-06	176	64	5	cb21342dd135cc80a50aafe7bf8bf31265db68dd
ToppCell	droplet-Lung-3m-Hematologic-myeloid-alveolar_macrophage\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSD3B7 LSR SGK1 MS4A8 CARD11	5.47e-06	176	64	5	e74ad0db3b05897edcfabeb11008ede2b9eeb638
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BMPR1B MS4A8 DNAH9 NEK11 DNAH11	5.47e-06	176	64	5	dee780cfa85234a7cd7bf440b66b84cec959893e
ToppCell	droplet-Lung-3m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSD3B7 LSR SGK1 MS4A8 CARD11	5.63e-06	177	64	5	71919b5c9bfa87fdd2cd44dfa057b66ea081be5d
ToppCell	droplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSD3B7 LSR SGK1 MS4A8 CARD11	6.79e-06	184	64	5	8fa30789c9d583188667cf375d2218e392dd40bc
ToppCell	droplet-Lung-3m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSD3B7 LSR BMPR1B MS4A8 CARD11	6.97e-06	185	64	5	57c1eb50a4456d20953e48d5dc3b0ea3d0d81b6d
ToppCell	droplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSD3B7 LSR SGK1 MS4A8 CARD11	6.97e-06	185	64	5	4bee178ede12f56ba5f5bec44a03dc2a62c50137
ToppCell	droplet-Lung-nan-18m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSD3B7 LSR SGK1 MS4A8 CARD11	7.35e-06	187	64	5	f0c6e53035b00772377c4d5f761b4d11026b911a
ToppCell	droplet-Lung-nan-18m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSD3B7 LSR SGK1 MS4A8 CARD11	7.35e-06	187	64	5	f20e7a1751694390f535ffb27b97e887220f8695
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MORC1 PIK3C2G SGK1 TPH2	4.80e-05	139	64	4	9e9f29f92dbe65b26cc78b3a1c00778c6a701f5b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B PIK3C2G TPH2 FREM1	5.81e-05	146	64	4	e887e9de895fd453faa703997ef372cc6410fc49
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	BMPR1B MS4A8 DNAH9 DNAH11	7.51e-05	156	64	4	10d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-AT1_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 LSR RBM15B WRAP53	7.70e-05	157	64	4	a93866f051472506f1468f379c0d5313e02c9731
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	IL32 MAPK3 SMCR8 CAMSAP2	8.29e-05	160	64	4	c2b5fadb4bac17fafc08831f6d3f4ff96ada7e70
ToppCell	Ciliated_cells-A-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	BMPR1B SHC4 DNAH9 DNAH11	8.91e-05	163	64	4	43194c6127df1ce3d29242f719645de3c11fd7c0
ToppCell	Bronchial_Brush-Epithelial-Goblet_2\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	IL32 VNN1 CARD11 PMEPA1	9.56e-05	166	64	4	8ac0a769be886d16642e7e6334471ebadd1a426b
ToppCell	Bronchial_Brush-Epithelial-Goblet_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	IL32 VNN1 CARD11 PMEPA1	9.78e-05	167	64	4	806d1c00c137da0c5f042adf866873eb6dd4bb27
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MS4A8 PLEKHB1 NEK11 DNAH11	1.00e-04	168	64	4	9a8709d34865cfa668d8f3335dc34fc86fc32482
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	TRAF4 WRAP53 PMEPA1 SH3D21	1.00e-04	168	64	4	968405ea56f7d001ef83ff9274610923c3b2d55d
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DENND5B WASHC5 SH3D21 SOD2	1.10e-04	172	64	4	965a9f62b73a7e3531c343121a7c507b7e1bfe05
ToppCell	3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MS4A8 DNAH9 NEK11 DNAH11	1.12e-04	173	64	4	c3762655caa79ac4879876f470d32578a3c93b01
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AMPD3 BMPR1B PIK3C2G DGKH	1.12e-04	173	64	4	8ac2e9d39c0f76e674f8bd59d1da246bab4867c8
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RBM15B CAMSAP2 SH3D21 HARBI1	1.20e-04	176	64	4	76fdf211bce101e83a27d822cb399487bd107027
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	AMPD3 BMPR1B PIK3C2G FER1L6	1.22e-04	177	64	4	8e4005fad50e6f919da175f3b9ae58849dbd60b1
ToppCell	3'-Adult-Distal_Rectal-Epithelial-Tuft-related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL32 CLGN VNN1 SGK1	1.25e-04	178	64	4	a95bb77a2c2ce7c38989e6f971812f7ee9f5bd4b
ToppCell	BAL-Control-Myeloid-MoAM-MoAM2-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AMPD3 SGK1 RELB SOD2	1.28e-04	179	64	4	898425fa81526a2e00fca7a25085229ff1f31069
ToppCell	BAL-Control-Myeloid-MoAM-MoAM2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AMPD3 SGK1 RELB SOD2	1.28e-04	179	64	4	2fca4117c58824562ec80c7713fe15689a28efb3
ToppCell	BAL-Control-Myeloid-MoAM-MoAM2\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	AMPD3 SGK1 RELB SOD2	1.31e-04	180	64	4	f3d8329b7e754c1ed89b0f39b8cd9e2ae22f6725
ToppCell	BAL-Control-Myeloid-MoAM-MoAM2-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	AMPD3 SGK1 RELB SOD2	1.31e-04	180	64	4	dcec59d66995f701d816eaeea3ed1439a2f71b73
ToppCell	Control-Myeloid-MoAM2\|Control / Disease group,lineage and cell class （2021.01.30）	AMPD3 SGK1 RELB SOD2	1.31e-04	180	64	4	38892483a6a5388765aec87f0119c0b9bb5c7cbd
ToppCell	facs-Lung-18m-Epithelial-airway_epithelial-club_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK3 BMPR1B VNN1 FREM1	1.33e-04	181	64	4	4a0f1b121570430afb100c589657d931184e124f
ToppCell	normal_Pleural_Fluid-Myeloid_cells-CD1c+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	CCNG2 TRAF4 CARD11 SH3D21	1.33e-04	181	64	4	cc7ae1221a28bc404138a7efee0ad08a19cc3d86
ToppCell	facs-Lung-18m-Epithelial-airway_epithelial-club_cell-club_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK3 BMPR1B VNN1 FREM1	1.33e-04	181	64	4	34b49092f71128898af3b311170c4ed8adfefcff
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSD3B7 LSR MS4A8 CARD11	1.36e-04	182	64	4	3dec003bad0f3716cf8163861a9d4302a7d6df8c
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TRAF4 BMPR1B SHC4 FER1L6	1.36e-04	182	64	4	215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCell	droplet-Lung-nan-3m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSD3B7 LSR SGK1 CARD11	1.39e-04	183	64	4	ec3c05b9ce1e0fbb720e0dea41f1e28fd3fd878f
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSD3B7 LSR BMPR1B CARD11	1.39e-04	183	64	4	42dc31d587fbb9724b2f0be5ee8ed77233f67b86
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3C2G DNAH9 FREM1 DNAH11	1.42e-04	184	64	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3C2G DNAH9 FREM1 DNAH11	1.42e-04	184	64	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIK3C2G DNAH9 FREM1 DNAH11	1.42e-04	184	64	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Lung-nan-3m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSD3B7 LSR SGK1 CARD11	1.42e-04	184	64	4	3261d767d5e3d9e9fbac22ad73ca14e44beed89c
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSD3B7 LSR MS4A8 CARD11	1.45e-04	185	64	4	afbb88325e4a81c15ac1d0a004e3e1f4ba2ee87b
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSD3B7 LSR MS4A8 CARD11	1.45e-04	185	64	4	775b72319ef6acffd2c9a74293b9c1bccea33f42
ToppCell	NS-moderate-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MS4A8 DNAH9 NEK11 DNAH11	1.45e-04	185	64	4	5e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCell	NS-critical-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MS4A8 DNAH9 NEK11 DNAH11	1.48e-04	186	64	4	76033438426d8f9c72cd6691a7baf92104c9f03d
ToppCell	droplet-Lung-nan-21m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSD3B7 LSR SGK1 MS4A8	1.48e-04	186	64	4	f1aa0c58336d23bcbe52a59e7af954d20085bdb6
ToppCell	Influenza-Influenza_Severe-Myeloid-Neutrophil\|Influenza_Severe / Disease, condition lineage and cell class	CCNG2 MAPK14 VNN1 SOD2	1.48e-04	186	64	4	1dfcec9196d4db76fba3abc74e85885b1fb98b87
ToppCell	myeloid-Dendritic_cell-Plasmacytoid_dendritic_cell\|Dendritic_cell / Lineage, cell class and subclass	TRAF4 RECQL5 CARD11 PMEPA1	1.48e-04	186	64	4	858134580a09ed8a5eb6d6413d8ca9265904dfc1
ToppCell	droplet-Lung-nan-21m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSD3B7 LSR SGK1 MS4A8	1.48e-04	186	64	4	8f77e552e613b6e124443c7f6ef5c1316a5ff8db
ToppCell	NS-moderate-d_07-13-Epithelial-Ciliated\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MS4A8 DNAH9 NEK11 DNAH11	1.48e-04	186	64	4	85787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCell	BAL-Control-Myeloid-MoAM-MoAM5\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AMPD3 TRAF4 RELB MAPK3	1.51e-04	187	64	4	59d28f4ee1d463ae20abb8d7e7399b504d80698a
ToppCell	Control-Myeloid-MoAM5\|Control / Disease group,lineage and cell class （2021.01.30）	AMPD3 TRAF4 RELB MAPK3	1.51e-04	187	64	4	8769341be67382cea2a590d962f4def7c39de883
ToppCell	(0)_Myeloid-(01)_Dendritic_cell-(011)_pDC\|(01)_Dendritic_cell / immune cells in Peripheral Blood (logTPM normalization)	TRAF4 RECQL5 CARD11 PMEPA1	1.51e-04	187	64	4	068502efa3f0ac4cea2fa4a18d1c2f686a4fba54
ToppCell	BAL-Control-Myeloid-MoAM-MoAM5-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AMPD3 TRAF4 RELB MAPK3	1.51e-04	187	64	4	25adf648c05c21534b4913254e73d43fc5f64e06
ToppCell	BAL-Control-Myeloid-MoAM-MoAM5\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	AMPD3 TRAF4 RELB MAPK3	1.51e-04	187	64	4	3b0cfa9e5ea5e7d6dda689c328b9b5110b43ee1d
ToppCell	saliva-Mild-Moderate_progression_d12-25-Epithelial-Epithelial,_Airway-secretory_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LSR TRAF4 LPCAT4 SMCR8	1.51e-04	187	64	4	6e5c38425b6b1d4774f8dcea7e146f1eab785c3e
ToppCell	saliva-Mild-Moderate_progression_d12-25-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LSR TRAF4 LPCAT4 SMCR8	1.51e-04	187	64	4	43ef900b76f3c38bd8ce9858201124130c743d56
ToppCell	BAL-Control-Myeloid-MoAM-MoAM5-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	AMPD3 TRAF4 RELB MAPK3	1.51e-04	187	64	4	0d589de12108230ced5b60229564f4a181e2f172
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-myeloid-myeloid_granulocytic\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CLGN DLC1 VNN1 FREM1	1.54e-04	188	64	4	36ff615154d6d9e3ba6ccb73a0f11574bcbf5ece
ToppCell	-Unknown-Endothelial-Myofibroblast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 HSDL2 DGKH PDZRN3	1.54e-04	188	64	4	6468fa95ad0395395301115286f2d8c0df5d3882
ToppCell	-Unknown-Endothelial\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 HSDL2 DGKH PDZRN3	1.54e-04	188	64	4	7a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell	-Unknown\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK3 HSDL2 DGKH PDZRN3	1.54e-04	188	64	4	9cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell	droplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSD3B7 SGK1 CARD11 DNAH11	1.57e-04	189	64	4	98f517af255ef234eefc3ed7e6c1d63331ab8af0
ToppCell	Control-Myeloid-MoAM1\|Control / Disease group,lineage and cell class （2021.01.30）	AMPD3 SGK1 RELB SOD2	1.57e-04	189	64	4	55d5c2fb9e6ab556d42c83a1e985ee66e4cf9dba
ToppCell	droplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSD3B7 SGK1 CARD11 DNAH11	1.57e-04	189	64	4	f7e9b6e6a4de297b660a5b6c9a62f860c147185e
ToppCell	IPF-Epithelial-Aberrant_Basaloid\|Epithelial / Disease state, Lineage and Cell class	DOCK3 IL32 CARD11 PMEPA1	1.57e-04	189	64	4	4178be3292ff4a8a1d8098f638d4b8d15164d2c6
ToppCell	BAL-Control-Myeloid-MoAM-MoAM1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	AMPD3 SGK1 RELB SOD2	1.57e-04	189	64	4	ebb5e069fdca7cf8ffac16a57572e92d2593c86a
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	MS4A8 DNAH9 NEK11 DNAH11	1.57e-04	189	64	4	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	BAL-Control-Myeloid-MoAM-MoAM1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	AMPD3 SGK1 RELB SOD2	1.57e-04	189	64	4	a59e4eaff430a443f9fa7edabe64e66a15b6bffb
ToppCell	BAL-Control-Myeloid-MoAM-MoAM1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AMPD3 SGK1 RELB SOD2	1.61e-04	190	64	4	5c8aa310886c64ee5dce4ba46a3dd178da549529
ToppCell	Nasal_Brush-Epithelial-Ciliated_2\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	MS4A8 DNAH9 NEK11 DNAH11	1.61e-04	190	64	4	9ce7df056bfb24d70db4c3c4a2c57d89115de877
ToppCell	Nasal_Brush-Epithelial-Ciliated_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	MS4A8 DNAH9 NEK11 DNAH11	1.61e-04	190	64	4	833481ace2800354712e2ce709d5cdfd0aed3d42
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HSD3B7 SGK1 CARD11 MAPK3	1.61e-04	190	64	4	da58227565ad6a690828dd8554dd3670222f8582
ToppCell	BAL-Control-Myeloid-MoAM-MoAM1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AMPD3 SGK1 RELB SOD2	1.61e-04	190	64	4	4b4fe93061c87605dddf5bec94fa07c749c722aa
ToppCell	droplet-Mammary_Gland-nan-18m-Epithelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VNN1 FGG PLEKHB1 PMEPA1	1.61e-04	190	64	4	313ad9ec736e3da5968dc9e9bbdfe508d935b552
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B PIK3C2G CARD11 FREM1	1.64e-04	191	64	4	3e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCell	(3)_MNP-(3)_DC_activated\|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)	CCNG2 IL32 RELB DNAH11	1.64e-04	191	64	4	0353bf797c4ef237b9bb82460c173c7d03cb8883
ToppCell	BAL-Severe-Myeloid-pDC-pDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DENND5B TRAF4 CARD11 PMEPA1	1.64e-04	191	64	4	989bf108c7f2c78dd7f14481570f1819673a5469
ToppCell	ASK428-Epithelial-Ciliated\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	MS4A8 DNAH9 NEK11 DNAH11	1.64e-04	191	64	4	0c4b926a28bc94f3cf4d68a911c0a189f6ff505e
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MS4A8 DNAH9 NEK11 DNAH11	1.64e-04	191	64	4	e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCell	BAL-Severe-Myeloid-pDC\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DENND5B TRAF4 CARD11 PMEPA1	1.64e-04	191	64	4	3e7fbe4af2c23b3b964becde843d2f088ad41c23
ToppCell	BAL-Severe-Myeloid-pDC-pDC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DENND5B TRAF4 CARD11 PMEPA1	1.64e-04	191	64	4	bc2f3c4e71e3a55fe76ea03f45746329a8fc81da
ToppCell	nucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MS4A8 DNAH9 NEK11 DNAH11	1.64e-04	191	64	4	9d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCell	COVID-19-Lymphoid-pDC\|COVID-19 / Condition, Lineage and Cell class	DENND5B TRAF4 CARD11 PMEPA1	1.64e-04	191	64	4	25343b11d42128ad16659e5519cd1673266cc505
ToppCell	nucseq-Epithelial-Epithelial_Airway\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MS4A8 DNAH9 NEK11 DNAH11	1.64e-04	191	64	4	1c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCell	BAL-Severe-Myeloid-pDC-pDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	DENND5B TRAF4 CARD11 PMEPA1	1.67e-04	192	64	4	d9ff2293358c8b031ba212021012e058014ff472
ToppCell	LAM-Epithelial-AirwayEpi\|LAM / Condition, Lineage and Cell class	BMPR1B MS4A8 DNAH9 DNAH11	1.67e-04	192	64	4	7404fc65be3b7bd09447725b43fa31819004dfee
ToppCell	Severe_COVID-19-Myeloid-pDC\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	DENND5B TRAF4 CARD11 PMEPA1	1.67e-04	192	64	4	f79424c643a375dfe4579eff7ac1ba191e28a283
ToppCell	BAL-Severe-Myeloid-pDC-pDC-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DENND5B TRAF4 CARD11 PMEPA1	1.67e-04	192	64	4	2e8611d65090e39f1a6e74c972288e7b68376d15
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	BMPR1B PIK3C2G RTN4 FREM1	1.67e-04	192	64	4	f7e7491426bbd6ed29a465b58bf67acb93dbb90a
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic-T_follicular_helper_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LSR TRAF4 RELB PMEPA1	1.67e-04	192	64	4	3e2a0f332e7f9833ba88f3c809cee78b65090401
ToppCell	Control-Myeloid-MoAM4\|Control / Disease group,lineage and cell class （2021.01.30）	LSR AMPD3 SGK1 SOD2	1.67e-04	192	64	4	1da7c303a2e36af4a9d8ec30a11380d9b1897922
ToppCell	BAL-Severe-Myeloid-pDC\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	DENND5B TRAF4 CARD11 PMEPA1	1.67e-04	192	64	4	43569726df281eebe57499e0993b9fd9d36118c2
ToppCell	BAL-Control-Myeloid-MoAM-MoAM3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AMPD3 SGK1 RELB SOD2	1.71e-04	193	64	4	837c61408462c519912ecf3b83fdc72cd85fe88f
ToppCell	Control-Myeloid-MoAM3\|Control / Disease group,lineage and cell class （2021.01.30）	AMPD3 SGK1 RELB SOD2	1.71e-04	193	64	4	97d2f12be43fc26efa84ac4c6119132928a123de
ToppCell	Control-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	MS4A8 DNAH9 NEK11 DNAH11	1.71e-04	193	64	4	0e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	MS4A8 DNAH9 NEK11 DNAH11	1.71e-04	193	64	4	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	BAL-Control-Myeloid-MoAM-MoAM3\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	AMPD3 SGK1 RELB SOD2	1.71e-04	193	64	4	d81840e1322507552b7726bf7828309375162324
Drug	peroxynitrite	MAPK14 RTN4 TPH2 CARD11 RELB FGG MAPK3 GFER SOD2	9.61e-07	373	64	9	CID000104806
Drug	Tenoxicam [59804-37-4]; Down 200; 11.8uM; MCF7; HT_HG-U133A	DOCK3 AMPD3 MAPK14 DLC1 ATN1 DNAH17 RELB	1.29e-06	196	64	7	4182_DN
Drug	PTIO	TRAF4 SGK1 MAPK3 SOD2	4.34e-06	39	64	4	CID002733513
Drug	2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide	TRAF4 CARD11 MAPK3 SOD2	1.39e-05	52	64	4	CID011776156
Drug	Trimethylcolchicinic acid [3482-37-9]; Up 200; 11.6uM; HL60; HT_HG-U133A	TRAF4 RECQL5 RELB WRAP53 CAMSAP2 GFER	1.66e-05	192	64	6	2146_UP
Drug	AC1OAGKW	CCNG2 PIK3C2G HSPA4L SGK1 DGKH MAPK3	1.71e-05	193	64	6	CID006857413
Drug	Tribenoside [10310-32-4]; Up 200; 8.4uM; MCF7; HT_HG-U133A	MAPK14 ATN1 RECQL5 DNAH17 RELB SH3D21	1.76e-05	194	64	6	3507_UP
Drug	Sulfaphenazole [526-08-9]; Down 200; 12.8uM; HL60; HT_HG-U133A	CCNG2 TRAF4 MAPK14 RELB MAPK3 SOD2	1.81e-05	195	64	6	1836_DN
Drug	Crotamiton [483-63-6]; Down 200; 19.6uM; HL60; HT_HG-U133A	DLC1 DNAH17 LPCAT4 CAMKMT WRAP53 NEK11	1.81e-05	195	64	6	3050_DN
Drug	Mevalonic-D, L acid lactone [674-26-0]; Down 200; 30.8uM; HL60; HT_HG-U133A	DENND5B CCNG2 CLGN HSPA4L RECQL5 WRAP53	1.87e-05	196	64	6	2718_DN
Drug	Vitamin K2 [11032-49-8]; Down 200; 9uM; PC3; HT_HG-U133A	CCNG2 AMPD3 MAPK14 CAMKMT PLEKHB1 NEK11	1.92e-05	197	64	6	3798_DN
Drug	V2O5	CCNG2 TRAF4 MAPK3 SOD2	2.01e-05	57	64	4	CID000014814
Drug	Chenodiol [474-25-9]; Down 200; 10.2uM; MCF7; HT_HG-U133A	MAPK14 ATN1 PDHA1 SGK1 RECQL5 CAMKMT	2.03e-05	199	64	6	7433_DN
Drug	Tiron	TRAF4 RELB MAPK3 SOD2	4.28e-05	69	64	4	CID000009001
Drug	bovine serum albumin-corticosterone conjugate	MAPK14 MAPK3	4.65e-05	4	64	2	ctd:C439264
Drug	corticosterone-21-hemisuccinate	MAPK14 MAPK3	4.65e-05	4	64	2	ctd:C067957
Drug	AC1LU7RZ	TPH2 SOD2	4.65e-05	4	64	2	CID001549117
Drug	AC1L1H7K	MAPK14 PIK3C2G RELB MAPK3 SOD2	5.33e-05	144	64	5	CID000004010
Drug	SU11274	IL32 MAPK14 MAPK3	5.90e-05	27	64	3	CID009549297
Drug	hematoporphyrin	MAGEC1 GFER SOD2	5.90e-05	27	64	3	CID000011103
Drug	sodium arsenite	MAPK14 HSPA4L RELB MAPK3 SOD2	6.89e-05	152	64	5	CID000443495
Drug	SP600125	CCNG2 MAPK14 PIK3C2G HSPA4L RELB MAPK3 SOD2	6.91e-05	362	64	7	CID000008515
Drug	DETA/NO	CARD11 RELB MAPK3 SOD2	7.65e-05	80	64	4	CID000004518
Drug	t-butylcyclohexane	MAPK3 SOD2	7.74e-05	5	64	2	CID000018508
Drug	Nitrosomethylurethane	MAPK14 MAPK3	7.74e-05	5	64	2	ctd:D009605
Drug	6-OHDA	MAPK14 HSPA4L TPH2 RELB MAPK3 SOD2	8.10e-05	255	64	6	CID000004624
Drug	3,4-dihydroxybenzohydroxamic acid	MAPK14 MAPK3 SOD2	8.15e-05	30	64	3	ctd:C035419
Drug	cotylenin A	CCNG2 IL32 MAPK3	9.00e-05	31	64	3	ctd:C423222
Drug	Dihydroergotoxine mesylate [8067-24-1]; Up 200; 6.4uM; HL60; HT_HG-U133A	CCNG2 SGK1 RECQL5 DNAH17 CAMSAP2	1.02e-04	165	64	5	2136_UP
Drug	Pergolide mesylate [66104-23-2]; Up 200; 9.8uM; HL60; HT_HG-U133A	DENND5B CCNG2 SGK1 DNAH17 CAMSAP2	1.04e-04	166	64	5	2403_UP
Drug	methyl(acetoxymethyl)nitrosamine	MAPK14 MAPK3	1.16e-04	6	64	2	ctd:C014659
Drug	diacetyldichlorofluorescein	MAPK3 SOD2	1.16e-04	6	64	2	ctd:C029569
Drug	dimethylarsine	MAPK3 SOD2	1.16e-04	6	64	2	CID000079055
Drug	Acetylcholine	MAPK14 PKD1 MAPK3 SOD2	1.26e-04	91	64	4	ctd:D000109
Drug	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	SGK1 TPH2 RELB MAPK3 SOD2	1.27e-04	173	64	5	ctd:C063509
Drug	8-Bromo Cyclic Adenosine Monophosphate	IL32 CLGN SGK1 TPH2 MAPK3 PMEPA1 PDZRN3 FER1L6 SOD2	1.31e-04	693	64	9	ctd:D015124
Drug	AC1NUZ8M	PKD1 CARD11 RELB MAPK3	1.32e-04	92	64	4	CID000073211
Drug	monomethylarsonous acid	CCNG2 MAPK14 ATN1 DNAH17 UBR3 CAMKMT CARD11 MAPK3 SOD2	1.33e-04	694	64	9	ctd:C406082
Drug	C15H20O3	MAPK14 PKD1 CARD11 RELB MAPK3	1.34e-04	175	64	5	CID000004692
Drug	17-AAG; Up 200; 1uM; HL60; HT_HG-U133A	CCNG2 AMPD3 HSPA4L RECQL5 DNAH17	1.41e-04	177	64	5	2678_UP
Drug	trifluoperazine dihydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A	DENND5B CCNG2 DLC1 DNAH17 RELB	1.65e-04	183	64	5	5221_UP
Drug	Naftifine hydrochloride [65473-14-5]; Up 200; 12.4uM; MCF7; HT_HG-U133A	CCNG2 AMPD3 CLGN DNAH17 RELB	1.74e-04	185	64	5	3536_UP
Drug	C2-ceramide	MAPK14 PIK3C2G NSL1 DGKH RELB MAPK3	1.76e-04	294	64	6	CID000002505
Drug	17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A	CCNG2 AMPD3 MAPK14 HSPA4L SGK1	1.78e-04	186	64	5	5566_UP
Drug	MnTMPyP	MAPK14 MAPK3 SOD2	1.80e-04	39	64	3	CID000004233
Drug	vanadium pentoxide	CCNG2 TRAF4 MAPK3 SOD2	1.82e-04	100	64	4	ctd:C066075
Drug	Methotrimeprazine maleat salt [7104-38-3]; Up 200; 9uM; PC3; HT_HG-U133A	CCNG2 ATN1 VNN1 RELB SH3D21	1.87e-04	188	64	5	3701_UP
Drug	Methiothepin maleate [19728-88-2]; Up 200; 8.4uM; MCF7; HT_HG-U133A	DENND5B CCNG2 ATN1 RELB SOD2	1.92e-04	189	64	5	3231_UP
Drug	Clomipramine hydrochloride [17321-77-6]; Up 200; 11.4uM; MCF7; HT_HG-U133A	CLGN MAPK14 ATN1 RELB MAGEC1	1.96e-04	190	64	5	6825_UP
Drug	guanosine 3',5'-cyclic monophosphoric acid	MAPK14 PKD1 CARD11 FGG MAPK3 DNAH9 GFER SOD2	2.06e-04	577	64	8	CID000000295
Drug	Biliton	DNAH17 DNAH9 DNAH11	2.09e-04	41	64	3	CID000002974
Drug	MEK1/2 inhibitor	MAPK14 PIK3C2G SHC4 RELB MAPK3	2.11e-04	193	64	5	CID009549284
Drug	rhizopine	DOCK3 ATN1	2.15e-04	8	64	2	CID000127741
Drug	1,2,4-trimethylcyclohexane	MAPK3 SOD2	2.15e-04	8	64	2	CID000091517
Drug	phytosphingosine	MAPK14 MAPK3	2.15e-04	8	64	2	ctd:C012491
Drug	CPS 11	MAPK14 MAPK3	2.15e-04	8	64	2	ctd:C494620
Drug	Tadjakonine [11087-94-8]; Down 200; 7.4uM; MCF7; HT_HG-U133A	AMPD3 CLGN DLC1 RECQL5 GFER	2.16e-04	194	64	5	4424_DN
Drug	Gallamine triethiodide [65-29-2]; Down 200; 4.4uM; MCF7; HT_HG-U133A	TRAF4 MAPK14 RECQL5 RELB PDZRN3	2.16e-04	194	64	5	2221_DN
Drug	5155877; Up 200; 10uM; MCF7; HT_HG-U133A	AMPD3 CLGN MAPK14 ATN1 CAMKMT	2.16e-04	194	64	5	6549_UP
Drug	ionomycin calcium salt; Up 200; 2uM; MCF7; HT_HG-U133A_EA	CCNG2 AMPD3 ATN1 RELB NEK11	2.22e-04	195	64	5	871_UP
Drug	F0447-0125; Down 200; 10uM; MCF7; HT_HG-U133A	CLGN DLC1 ATN1 RECQL5 DNAH9	2.22e-04	195	64	5	6424_DN
Drug	Metrizamide [31112-62-6]; Up 200; 5uM; HL60; HT_HG-U133A	CCNG2 CLGN MAPK14 DNAH17 SOD2	2.22e-04	195	64	5	1318_UP
Drug	Ethionamide [536-33-4]; Up 200; 24uM; PC3; HT_HG-U133A	MORC1 AMPD3 BMPR1B ATN1 NEK11	2.22e-04	195	64	5	4593_UP
Drug	Piperacetazine [3819-00-9]; Up 200; 9.8uM; PC3; HT_HG-U133A	AMPD3 DLC1 ATN1 MAPK3 NEK11	2.22e-04	195	64	5	5834_UP
Drug	N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Down 200; 25.2uM; PC3; HT_HG-U133A	DENND5B TRAF4 MAPK14 CAMKMT GFER	2.22e-04	195	64	5	3755_DN
Drug	vanadyl	MAPK14 PIK3C2G DNAH17 MAPK3 DNAH9 DNAH11	2.22e-04	307	64	6	CID000061671
Drug	Cephalothin sodium salt [58-71-9]; Up 200; 9.6uM; PC3; HT_HG-U133A	AMPD3 ATN1 VNN1 RECQL5 PLEKHB1	2.27e-04	196	64	5	4482_UP
Drug	Betahistine mesylate [54856-23-4]; Down 200; 17.2uM; MCF7; HT_HG-U133A	CCNG2 C2CD3 MAPK3 CAMSAP2 NEK11	2.27e-04	196	64	5	4956_DN
Drug	Azlocillin sodium salt [37091-65-9]; Down 200; 8.2uM; MCF7; HT_HG-U133A	TRAF4 RECQL5 LPCAT4 CAMKMT SOD2	2.27e-04	196	64	5	3468_DN
Drug	Drugs, Chinese Herbal	CCNG2 CLGN MAPK14 DLC1 HSPA4L SHC4 RELB MAPK3	2.29e-04	586	64	8	ctd:D004365
Drug	Carbetapentane citrate [23142-01-0]; Down 200; 7.6uM; MCF7; HT_HG-U133A	CCNG2 CLGN ATN1 PLEKHB1 NEK11	2.32e-04	197	64	5	5610_DN
Drug	Nimesulide [51803-78-2]; Down 200; 13uM; MCF7; HT_HG-U133A	AMPD3 TRAF4 DNAH17 RELB PLEKHB1	2.32e-04	197	64	5	2275_DN
Drug	Diazoxide [364-98-7]; Up 200; 17.4uM; MCF7; HT_HG-U133A	DLC1 RECQL5 GFER NEK11 SOD2	2.32e-04	197	64	5	7168_UP
Drug	Bupivacaine hydrochloride [18010-40-7]; Up 200; 12.4uM; HL60; HT_HG-U133A	DENND5B TRAF4 DLC1 DNAH9 GFER	2.32e-04	197	64	5	2404_UP
Drug	Metoclopramide monohydrochloride [7232-21-5]; Down 200; 11.8uM; MCF7; HT_HG-U133A	AMPD3 CLGN MAPK14 DLC1 PLEKHB1	2.38e-04	198	64	5	4750_DN
Drug	Nilutamide [63612-50-0]; Up 200; 12.6uM; HL60; HT_HG-U133A	TRAF4 DLC1 DNAH17 CAMKMT SH3D21	2.38e-04	198	64	5	3104_UP
Drug	Sisomicin sulfate [53179-09-2]; Up 200; 2.8uM; HL60; HT_HG-U133A	VNN1 WRAP53 GFER SH3D21 NEK11	2.38e-04	198	64	5	2493_UP
Drug	Suprofen [40828-46-4]; Down 200; 15.4uM; PC3; HT_HG-U133A	TRAF4 ATN1 RECQL5 DNAH17 SH3D21	2.38e-04	198	64	5	4005_DN
Drug	Chlorpropamide [94-20-2]; Down 200; 14.4uM; MCF7; HT_HG-U133A	CCNG2 CLGN RECQL5 LPCAT4 NEK11	2.38e-04	198	64	5	5391_DN
Drug	Nabumetone [42924-53-8]; Up 200; 17.6uM; MCF7; HT_HG-U133A	DENND5B ATN1 VNN1 RELB SH3D21	2.38e-04	198	64	5	6487_UP
Drug	Propranolol hydrochloride [318-98-9]; Down 200; 13.6uM; MCF7; HT_HG-U133A	DENND5B CLGN ATN1 DNAH17 RELB	2.38e-04	198	64	5	3396_DN
Drug	Myosmine [532-12-7]; Down 200; 27.4uM; MCF7; HT_HG-U133A	AMPD3 CLGN MAPK14 DLC1 RECQL5	2.38e-04	198	64	5	4759_DN
Drug	(S)-(-)-Atenolol [93379-54-5]; Down 200; 15uM; MCF7; HT_HG-U133A	AMPD3 RECQL5 DNAH17 LPCAT4 NEK11	2.38e-04	198	64	5	6444_DN
Drug	Griseofulvin [126-07-8]; Up 200; 11.2uM; MCF7; HT_HG-U133A	MORC1 DENND5B AMPD3 DLC1 ATN1	2.43e-04	199	64	5	4687_UP
Drug	Amrinone [60719-84-8]; Up 200; 21.4uM; MCF7; HT_HG-U133A	CLGN MAPK14 ATN1 RECQL5 LPCAT4	2.43e-04	199	64	5	6826_UP
Drug	Isometheptene mucate; Up 200; 8.2uM; MCF7; HT_HG-U133A	DENND5B AMPD3 CLGN RELB PLEKHB1	2.43e-04	199	64	5	6524_UP
Drug	Ald1.1-H_000455; Down 200; 10uM; PC3; HT_HG-U133A	ATN1 WRAP53 PLEKHB1 NEK11 SOD2	2.43e-04	199	64	5	7547_DN
Drug	Pipemidic acid [51940-44-4]; Up 200; 13.2uM; MCF7; HT_HG-U133A	DENND5B CLGN ATN1 GFER SH3D21	2.49e-04	200	64	5	6470_UP
Drug	Austricine [10180-88-8]; Down 200; 14.2uM; PC3; HT_HG-U133A	TRAF4 MAPK14 ATN1 DNAH17 CAMKMT	2.49e-04	200	64	5	4213_DN
Drug	Cefotetan [69712-56-7]; Down 200; 7uM; PC3; HT_HG-U133A	ATN1 RECQL5 DNAH17 RELB GFER	2.49e-04	200	64	5	3997_DN
Drug	juzentaihoto	MAPK14 MAPK3	2.76e-04	9	64	2	ctd:C063587
Drug	4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol	MAPK3 SOD2	2.76e-04	9	64	2	ctd:C556295
Drug	Nitrosourea Compounds	MAPK3 SOD2	2.76e-04	9	64	2	ctd:D009607
Drug	SB203580	CCNG2 TRAF4 BMPR1B MAPK14 PIK3C2G HSPA4L RELB MAPK3 SOD2	2.90e-04	771	64	9	CID000176155
Drug	carboxy-PTIO	CARD11 MAPK3 SOD2	2.95e-04	46	64	3	CID002733502
Drug	phenethyl caffeiate	MAPK14 RELB MAPK3 SOD2	3.00e-04	114	64	4	CID000108042
Drug	AC1NDP1U	MAPK14 MAPK3 GFER SOD2	3.11e-04	115	64	4	CID004629339
Drug	anthracene	TRAF4 DNAH9 SOD2	3.14e-04	47	64	3	CID000008418
Drug	NSC226080	CCNG2 BMPR1B IL32 MAPK14 PIK3C2G SGK1 PKD1 RELB MAPK3	3.22e-04	782	64	9	CID000005040
Drug	AC1NBU2S	PKD1 CARD11 RELB MAPK3	3.32e-04	117	64	4	CID004473765
Disease	Hereditary Diffuse Gastric Cancer	IL32 DLC1 PDHA1 BOP1 FGG MAPK3 SOD2	2.73e-06	293	62	7	C1708349
Disease	Stomach Neoplasms	IL32 DLC1 PDHA1 BOP1 FGG MAPK3 SOD2	2.99e-06	297	62	7	C0038356
Disease	Malignant neoplasm of stomach	IL32 DLC1 PDHA1 BOP1 FGG MAPK3 SOD2	3.19e-06	300	62	7	C0024623
Disease	Sezary Syndrome	IL32 BRD9 CARD11	2.49e-05	27	62	3	C0036920
Disease	rectal benign neoplasm (is_marker_for)	WRAP53 PMEPA1	2.60e-05	4	62	2	DOID:1984 (is_marker_for)
Disease	melancholic depression (implicated_via_orthology)	MORC1 TPH2	2.60e-05	4	62	2	DOID:1595 (implicated_via_orthology)
Disease	Kidney Neoplasm	IL32 MAPK3 SOD2	8.26e-05	40	62	3	C0022665
Disease	Malignant neoplasm of kidney	IL32 MAPK3 SOD2	1.18e-04	45	62	3	C0740457
Disease	Gastric Adenocarcinoma	BMPR1B MAPK14 EPHA8	1.18e-04	45	62	3	C0278701
Disease	ureteral obstruction (implicated_via_orthology)	RELB MAPK3	1.55e-04	9	62	2	DOID:5199 (implicated_via_orthology)
Disease	Diffuse Large B-Cell Lymphoma	SGK1 CARD11 SOD2	2.14e-04	55	62	3	C0079744
Disease	autosomal dominant polycystic kidney disease (implicated_via_orthology)	PKD1 GFER	3.89e-04	14	62	2	DOID:898 (implicated_via_orthology)
Disease	Cardiomyopathies, Primary	MAPK14 MAPK3 SOD2	4.19e-04	69	62	3	C0033141
Disease	Myocardial Diseases, Secondary	MAPK14 MAPK3 SOD2	4.19e-04	69	62	3	C0036529
Disease	Eye Abnormalities	BMPR1B FREM1	5.79e-04	17	62	2	C0015393
Disease	sensorineural hearing loss (implicated_via_orthology)	DNAH17 DNAH9	7.26e-04	19	62	2	DOID:10003 (implicated_via_orthology)
Disease	Dyslipidemias	VNN1 DNAH11	1.16e-03	24	62	2	C0242339
Disease	Dyslipoproteinemias	VNN1 DNAH11	1.16e-03	24	62	2	C0598784
Disease	congenital diaphragmatic hernia (biomarker_via_orthology)	FREM1 SOD2	1.16e-03	24	62	2	DOID:3827 (biomarker_via_orthology)
Disease	glucose measurement	CCNG2 PIK3C2G PDHA1 RTN4 BOP1	1.22e-03	380	62	5	EFO_0004468
Disease	Involutional paraphrenia	TPH2 SOD2	1.26e-03	25	62	2	C1571983
Disease	Psychosis, Involutional	TPH2 SOD2	1.26e-03	25	62	2	C1571984
Disease	pulmonary embolism	DNAH17 FGG	1.26e-03	25	62	2	EFO_0003827
Disease	Involutional Depression	TPH2 SOD2	1.26e-03	25	62	2	C0011574
Disease	Fever	TPH2 SOD2	1.47e-03	27	62	2	C0015967
Disease	caudate volume change measurement, age at assessment	DLC1 UBR3	1.47e-03	27	62	2	EFO_0008007, EFO_0021491
Disease	gastric adenocarcinoma (is_marker_for)	MAPK14 PMEPA1	1.59e-03	28	62	2	DOID:3717 (is_marker_for)
Disease	Child Development Disorders, Specific	CAMKMT MAPK3	1.70e-03	29	62	2	C0085997
Disease	Child Development Deviations	CAMKMT MAPK3	1.70e-03	29	62	2	C0085996
Disease	Major Depressive Disorder	MORC1 SGK1 TPH2 SOD2	1.72e-03	243	62	4	C1269683
Disease	Developmental Disabilities	CAMKMT MAPK3	1.82e-03	30	62	2	C0008073
Disease	osteoporosis (is_implicated_in)	IL32 SOD2	1.94e-03	31	62	2	DOID:11476 (is_implicated_in)
Disease	Cholestasis, Extrahepatic	MAPK14 MAPK3	2.07e-03	32	62	2	C0005398

Protein segments in the cluster

Peptide	Gene	Start	Entry
AESYNPPPEYLLSEE	BOP1	311	Q14137
PHLYPPEELIYFLDR	nan	101	Q9N2K0
PHLYPPEELIYFLDR	nan	101	Q9N2J8
PDVTHDPYEFLQSPE	BRD9	576	Q9H8M2
NEDTPYEAVHRHPYP	HSD3B7	146	Q9H2F3
PLHSVPLPAQEDYYS	ATN1	1166	P54259
HNSYYSVPELPTIPE	CCNG2	281	Q16589
YHQYIEEMLPPESPA	DNAH11	4191	Q96DT5
EEYQLPYHDLVPSDP	BMPR1B	421	O00238
QEPHSLPYPDLETYT	AMPD3	241	Q01432
YQPSPLPVHYELLTD	RBM15B	501	Q8NDT2
LPEEHPSAHEYYDPN	PDZRN3	386	Q9UPQ7
EPLPFTYLPRDHDSY	RELB	391	Q01201
PSAHVEFYLLPYPSE	PIK3C2G	1361	O75747
YFFPEHQLPSELEEP	MORC1	831	Q86VD1
YHPVVHPLDLKYDPD	NSL1	151	Q96IY1
EHYLEYREVPNSSPP	MAGEC1	1051	O60732
VYHPSPEESRDPTLY	LPCAT4	271	Q643R3
YHDPDDEPVADPYDQ	MAPK14	311	Q16539
TPLHIPETPAEYRYN	HARBI1	236	Q96MB7
EPPVSFPYLHYDATL	MSTO1	311	Q9BUK6
EQCDYPPLPSDHYSE	NEK7	251	Q8TDX7
RYQHLDPPSPNIDYI	FREM1	246	Q5H8C1
HEIPEDPLVAEEYYA	NEK11	466	Q8NG66
HPLQPDFFLDEYPEA	HSDL2	266	Q6YN16
FLQSPPEEEPEYHPD	MSANTD3	121	Q96H12
AHPYLEQYYDPTDEP	MAPK3	326	P27361
LYYILHPNEDEEPPM	DGKH	1101	Q86XP1
TYPYLQHEIDLPPTI	PMEPA1	136	Q969W9
PEHPAETEYDSLYPE	FGG	436	P02679
AYYEEQHPELTPLLE	IL32	106	P24001
LEPLSETYDSYHPLP	C2CD3	166	Q4AC94
EDLEPPYLPVHYSLS	DOCK3	1926	Q8IZD9
GYHEYIDENLPPESP	DNAH17	4136	Q9UFH2
EPQFYAEPHTYEEPG	EPHA8	606	P29322
ESYIHNILYEVPLPP	DENND5B	226	Q6ZUT9
FITDLSIPHPYAYPD	MS4A8	156	Q9BY19
YHQYIDAELPPESPY	DNAH9	4161	Q9NYC9
DAELPPESPYLYGLH	DNAH9	4166	Q9NYC9
EESPEDSKYFLPYHP	CARD11	481	Q9BXL7
PFYTDQYDQEHIKPP	CAMSAP2	56	Q08AD1
PHKEEEEEAYYPPAP	LSR	606	Q86X29
EEPEPYLAVYLHSEP	PKD1	2936	P98161
DAPAPAYHDPLYLED	REEP4	161	Q9H6H4
ADQDYEPPRLCYHPI	FER1L6	926	Q2WGJ9
YESIKHEPENPPPYE	RTN4	646	Q9NQC3
YNLPPELYHEGEQVE	WRAP53	196	Q9BUR4
SPPDYLQTVSHPEVY	SH3D21	56	A4FU49
PEYLAPEVLHKQPYD	SGK1	261	O00141
YPEDTVFYIPEDHKP	DLC1	801	Q96QB1
YNEPALPEEYSVPLF	SMCR8	21	Q8TEV9
HTLAAYYPDLPTPEQ	GFER	111	P55789
KENPDIYEENLHYPL	CAMKMT	301	Q7Z624
IPNPDYFEDDHPFLL	CLGN	391	O14967
PNEYDIPPASHVYSL	RECQL5	636	O94762
DHEYYNEIPGKQPPV	SHC4	371	Q6S5L8
IEAHYQDPSLPYPKE	WASHC5	991	Q12768
SLYPYLEDIPDPEVN	VNN1	91	O95497
DPEPPLEELGYHIYS	PDHA1	356	P08559
PDSYLEEEDNLPFPY	SPEM2	181	Q0P670
APEYTSAHAPAYIPD	SPEM3	346	A0A1B0GUW6
ELEAFYTNLHEVPYP	HSPA4L	441	O95757
PYQDYYEVVPPNAHE	PLEKHB1	171	Q9UF11
DIYDPFHPTDEAYSP	SCAF1	226	Q9H7N4
EDQLPLDYAKIYPDP	TRAF4	56	Q9BUZ4
HSLPDLPYDYGALEP	SOD2	26	P04179
YIRHGSDPLYTPEPD	TPH2	301	Q8IWU9
GYEEQQPEVPILYHD	UBR3	1521	Q6ZT12
CDEPHESYEPHAPYA	THEGL	76	P0DJG4