Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52L2P OR52B2 OR52N1 OR51H1 OR52E8 OR52L1 OR52E6 OR52N4 OR51F1	7.05e-15	431	43	15	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52L2P OR52B2 OR52N1 OR51H1 OR52E8 OR52L1 OR52E6 OR52N4 OR51F1	2.07e-10	884	43	15	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	TMEM63C OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52L2P OR52B2 OR52N1 OR51H1 OR52E8 OR52L1 OR52E6 OR52N4 OR51F1	8.34e-09	1353	43	16	GO:0004888
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52L2P OR52B2 OR52N1 RYR2 OR51H1 OR52E8 OR52L1 OR52E6 OR52N4 OR51F1	2.17e-15	524	42	16	GO:0009593
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52L2P OR52B2 OR52N1 OR51H1 OR52E8 OR52L1 OR52E6 OR52N4 OR51F1	3.03e-15	432	42	15	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52L2P OR52B2 OR52N1 OR51H1 OR52E8 OR52L1 OR52E6 OR52N4 OR51F1	8.92e-15	465	42	15	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52L2P OR52B2 OR52N1 OR51H1 OR52E8 OR52L1 OR52E6 OR52N4 OR51F1	1.65e-14	485	42	15	GO:0050907
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52L2P OR52B2 OR52N1 OR51H1 OR52E8 OR52L1 OR52E6 OR52N4 OR51F1	9.52e-14	547	42	15	GO:0007606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52L2P OR52B2 OR52N1 OR51H1 OR52E8 OR52L1 OR52E6 OR52N4 OR51F1	2.34e-13	582	42	15	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52L2P OR52B2 OR52N1 RYR2 OR51H1 OR52E8 OR52L1 OR52E6 OR52N4 OR51F1	3.07e-13	722	42	16	GO:0051606
GeneOntologyBiologicalProcess	sensory perception	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 USH2A OR51I1 OR52L2P OR52B2 OR52N1 OR51H1 OR52E8 OR52L1 OR52E6 OR52N4 OR51F1	1.18e-10	1072	42	16	GO:0007600
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52L2P OR52B2 OR52N1 OR51H1 OR52E8 OR52L1 OR52E6 OR52N4 OR51F1	4.55e-08	1395	42	15	GO:0007186
GeneOntologyBiologicalProcess	vesicle tethering	EXOC2 TRAPPC2B TRAPPC2	3.74e-05	32	42	3	GO:0099022
GeneOntologyBiologicalProcess	Golgi vesicle transport	EXOC2 TRAPPC2B VPS13C SURF4 RAB33B TRAPPC2	6.01e-05	339	42	6	GO:0048193
GeneOntologyBiologicalProcess	COPII-coated vesicle budding	TRAPPC2B SURF4 TRAPPC2	1.05e-04	45	42	3	GO:0090114
GeneOntologyBiologicalProcess	vesicle targeting	EXOC2 TRAPPC2B TRAPPC2	4.08e-04	71	42	3	GO:0006903
GeneOntologyCellularComponent	TRAPPII protein complex	TRAPPC2B TRAPPC2	2.69e-04	12	43	2	GO:1990071
GeneOntologyCellularComponent	TRAPPIII protein complex	TRAPPC2B TRAPPC2	2.69e-04	12	43	2	GO:1990072
GeneOntologyCellularComponent	vesicle tethering complex	EXOC2 TRAPPC2B TRAPPC2	4.38e-04	72	43	3	GO:0099023
GeneOntologyCellularComponent	endosome	GRB14 ATP6V0C APOB TRAPPC2B SLC31A2 VPS13C RAB33B GP2 TRAPPC2	5.15e-04	1167	43	9	GO:0005768
GeneOntologyCellularComponent	TRAPP complex	TRAPPC2B TRAPPC2	5.51e-04	17	43	2	GO:0030008
Domain	Olfact_rcpt	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52B2 OR52N1 OR52E8 OR52L1 OR52E6 OR52N4	1.05e-11	393	38	12	IPR000725
Domain	GPCR_Rhodpsn_7TM	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52B2 OR52N1 OR52E8 OR52L1 OR52E6 OR52N4	4.74e-09	670	38	12	IPR017452
Domain	7tm_1	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52B2 OR52N1 OR52E8 OR52L1 OR52E6 OR52N4	5.32e-09	677	38	12	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52B2 OR52N1 OR52E8 OR52L1 OR52E6 OR52N4	6.07e-09	685	38	12	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52B2 OR52N1 OR52E8 OR52L1 OR52E6 OR52N4	6.69e-09	691	38	12	PS50262
Domain	GPCR_Rhodpsn	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52B2 OR52N1 OR52E8 OR52L1 OR52E6 OR52N4	6.80e-09	692	38	12	IPR000276
Domain	EGF_1	RELN USH2A GP2	1.49e-02	255	38	3	PS00022
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52B2 OR52N1 OR51H1 OR52E8 OR52L1 OR52E6 OR52N4 OR51F1	5.31e-14	417	31	14	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52B2 OR52N1 OR52E8 OR52L1 OR52E6 OR52N4 OR51F1	5.80e-13	389	31	13	M14091
Pathway	REACTOME_SENSORY_PERCEPTION	OR10H4 OR51F2 OR52K1 APOB OR52K2 OR10H3 OR51I1 OR52B2 OR52N1 OR51H1 OR52E8 OR52L1 OR52E6 OR52N4 OR51F1	8.53e-13	636	31	15	M41834
Pubmed	The human olfactory receptor gene family.	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52L2P OR52B2 OR52N1 OR51H1 OR52E8 OR52L1 OR52E6 OR52N4 OR51F1	6.33e-17	541	43	15	14983052
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52B2 OR51H1 OR52E8 OR52L1 OR52N4 OR51F1	7.34e-15	340	43	12	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52B2 OR51H1 OR52E8 OR52L1 OR52N4 OR51F1	7.34e-15	340	43	12	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52B2 OR51H1 OR52E8 OR52L1 OR52N4 OR51F1	8.15e-15	343	43	12	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR10H4 OR51F2 OR52K1 OR52K2 OR10H3 OR51I1 OR52B2 OR51H1 OR52E8 OR52L1 OR52N4 OR51F1	9.04e-15	346	43	12	14611657
Pubmed	Differential impact of Lhx2 deficiency on expression of class I and class II odorant receptor genes in mouse.	OR52K1 OR52K2 OR52B2 OR51F1	8.07e-08	33	43	4	17350283
Pubmed	Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not.	TRAPPC2B TRAPPC2	1.49e-06	2	43	2	14597397
Pubmed	Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda.	TRAPPC2B TRAPPC2	1.49e-06	2	43	2	10431248
Pubmed	Tissue and zonal-specific expression of an olfactory receptor transgene.	OR10H4 OR10H3	1.49e-06	2	43	2	9412503
Pubmed	Spondyloepiphyseal dysplasia tarda (SEDL, MIM #313400).	TRAPPC2B TRAPPC2	1.49e-06	2	43	2	12939648
Pubmed	Localization of the reeler gene relative to flanking loci on mouse chromosome 5.	RELN ABCB1	4.48e-06	3	43	2	1686837
Pubmed	Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice.	APOB NR1I3	4.48e-06	3	43	2	21778422
Pubmed	Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells.	NR1I3 ABCB1	4.48e-06	3	43	2	21517853
Pubmed	[Genetic analysis for prevention of steroid-induced osteonecrosis of the femoral head].	APOB ABCB1	4.48e-06	3	43	2	17548929
Pubmed	Xenobiotic Nuclear Receptors Pregnane X Receptor and Constitutive Androstane Receptor Regulate Antiretroviral Drug Efflux Transporters at the Blood-Testis Barrier.	NR1I3 ABCB1	4.48e-06	3	43	2	28970358
Pubmed	Combination analysis of three polymorphisms for predicting the risk for steroid-induced osteonecrosis of the femoral head.	APOB ABCB1	4.48e-06	3	43	2	18696186
Pubmed	Mouse multidrug resistance 1a/3 gene is the earliest known endothelial cell differentiation marker during blood-brain barrier development.	RELN ABCB1	4.48e-06	3	43	2	7734734
Pubmed	A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1.	TRAPPC2B TRAPPC2	8.94e-06	4	43	2	11134351
Pubmed	Direct detection and isolation of restriction landmark genomic scanning (RLGS) spot DNA markers tightly linked to a specific trait by using the RLGS spot-bombing method.	RELN ABCB1	8.94e-06	4	43	2	7777557
Pubmed	Estimation of genetic distances between "reeler" and nearby loci on mouse chromosome 5.	RELN ABCB1	8.94e-06	4	43	2	1783386
Pubmed	Impact of genetic variants of ABCB1, APOB, CAV1, and NAMPT on susceptibility to pancreatic ductal adenocarcinoma in Chinese patients.	APOB ABCB1	8.94e-06	4	43	2	32243098
Pubmed	The reeler gene: a clue to brain development and evolution.	RELN ABCB1	8.94e-06	4	43	2	1627461
Pubmed	Structure, genetic mapping, and expression of the mouse Hgf/scatter factor gene.	RELN ABCB1	1.49e-05	5	43	2	8081873
Pubmed	High-resolution genetic map and YAC contig around the mouse neurological locus reeler.	RELN ABCB1	2.23e-05	6	43	2	7894155
Pubmed	Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia.	NR1I3 ABCB1	3.12e-05	7	43	2	18294295
Pubmed	Functional organization of the yeast proteome by systematic analysis of protein complexes.	TRAPPC2B TRAPPC2	3.12e-05	7	43	2	11805826
Pubmed	Gene structure and expression study of the SEDL gene for spondyloepiphyseal dysplasia tarda.	TRAPPC2B TRAPPC2	4.16e-05	8	43	2	11031107
Pubmed	Genetic mapping of 18S ribosomal RNA-related loci to mouse chromosomes 5, 6, 9, 12, 17, 18, 19, and X.	APOB ABCB1	5.35e-05	9	43	2	8995758
Pubmed	Identification of genetic variants associated with response to statin therapy.	APOB ABCB1	5.35e-05	9	43	2	19667110
Pubmed	TRAPP Complexes in Secretion and Autophagy.	TRAPPC2B TRAPPC2	1.55e-04	15	43	2	27066478
Pubmed	Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis.	OR10H4 OR10H3	1.77e-04	16	43	2	17521568
Pubmed	Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion.	APOB SURF4	1.77e-04	16	43	2	38042368
Pubmed	Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response.	APOB ABCB1	6.79e-04	31	43	2	20031551
Pubmed	Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex.	ATP6V0C RELN	8.66e-04	35	43	2	37758766
Cytoband	11p15.4	OR51F2 OR52K1 OR52K2 OR51I1 OR52L2P OR52B2 OR52N1 OR51H1 OR52E8 OR52L1 OR52E6 OR52N4 OR51F1	4.47e-21	200	43	13	11p15.4
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	OR51F2 OR52K1 OR52K2 OR51I1 OR52L2P OR52B2 OR52N1 OR51H1 OR52E8 OR52L1 OR52E6 OR52N4 OR51F1	3.31e-15	564	43	13	chr11p15
GeneFamily	Olfactory receptors, family 52	OR52K1 OR52K2 OR52L2P OR52B2 OR52N1 OR52E8 OR52L1 OR52E6 OR52N4	6.98e-17	49	31	9	165
GeneFamily	Olfactory receptors, family 51	OR51F2 OR51I1 OR51H1 OR51F1	9.15e-07	44	31	4	164
GeneFamily	Olfactory receptors, family 10	OR10H4 OR10H3	5.70e-03	66	31	2	157
Coexpression	KRAS.600_UP.V1_DN	APOB NR1I3 NYNRIN RYR2 ABCB1 GP2	3.90e-06	279	40	6	M2880
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Epcam____brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APOB C1QTNF3 SLC22A14 ABCB1	1.63e-05	162	42	4	de0fde4310a56dc96bfc134c44d104993526d9bc
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN APOB USH2A RYR2	2.68e-05	184	42	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN APOB USH2A RYR2	2.68e-05	184	42	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN APOB USH2A RYR2	2.68e-05	184	42	4	2b19a8c5f823e00812908b23e66bb4e563278aff
Computational	Genes in the cancer module 236.	APOB MBTPS2	4.94e-04	18	20	2	MODULE_236
Disease	X-linked spondyloepiphyseal dysplasia tarda (implicated_via_orthology)	TRAPPC2B TRAPPC2	1.21e-06	2	33	2	DOID:0080362 (implicated_via_orthology)
Disease	spondyloepiphyseal dysplasia congenita (implicated_via_orthology)	TRAPPC2B TRAPPC2	1.81e-05	6	33	2	DOID:14789 (implicated_via_orthology)
Disease	familial hyperlipidemia (is_implicated_in)	APOB ABCB1	3.38e-05	8	33	2	DOID:1168 (is_implicated_in)
Disease	Autism Spectrum Disorders	RELN USH2A RYR2	1.18e-04	85	33	3	C1510586
Disease	retinitis pigmentosa (is_implicated_in)	IFT140 USH2A	9.68e-04	41	33	2	DOID:10584 (is_implicated_in)
Disease	Thromboembolism	OR52K1 OR52K2	1.11e-03	44	33	2	HP_0001907
Disease	total lipids in small LDL	APOB NYNRIN	1.27e-03	47	33	2	EFO_0022168
Disease	phospholipids in medium LDL measurement	APOB NYNRIN	1.38e-03	49	33	2	EFO_0022183

Protein segments in the cluster

Peptide	Gene	Start	Entry
FTHEVDFDDFMMPFQ	ANKEF1	746	Q9NU02
VFVYDMTNMASFHSL	RAB33B	111	Q9H082
GMFNTESSFHMFPYQ	RAD17	176	O75943
GMFFQSMATFFTGFI	ABCB1	191	P08183
HIFGITFSFTQAMMY	ABCB1	936	P08183
HTRHMGTMFEQFVQF	NR1I3	121	Q14994
VQMFFTHTFTGMESG	OR52N4	101	Q8NGI2
SFSFFGNVMSMASVQ	CPSF1	71	Q10570
FITNFMFMAHHCLGF	TMEM63C	196	Q9P1W3
MLFHGMSADFTSENF	EXOC2	151	Q96KP1
CIVQMFFLHGFTFME	OR51F1	106	A6NGY5
CIAQMFFLHGFTFME	OR51F2	111	Q8NH61
FDACIMQMFFIHVFG	OR51H1	96	Q8NH63
VQMFFIHTFSFMESG	OR51I1	101	Q9H343
FDACVTQGFFVHMMF	OR52B2	96	Q96RD2
TQGFFVHMMFVGESA	OR52B2	101	Q96RD2
SQMFFIHFFTVMESI	OR52E6	101	Q96RD3
SRFSVQMFMFAGHYD	GP2	441	P55259
FHVSASTFLQFEMSM	RELN	1656	P78509
QMFFSFMFGFTHSFL	OR10H3	101	O60404
QMFFSFMFGFTHSFL	OR10H4	101	Q8NGA5
FMFGFTHSFLLLVMG	OR10H4	106	Q8NGA5
GVYFFTFSMMKHEDV	C1QTNF3	161	Q9BXJ4
HFSNVFRSVMAPFTM	APOB	1891	P04114
MAMHFIFSDTAVLLF	SLC31A2	1	O15432
HVTSDDFCFFQMLMG	GFOD2	216	Q3B7J2
FNFGMVFGVIAMFSS	MBTPS2	76	O43462
MYFFPEHMVSFATET	GRB14	201	Q14449
PSIMSAFFMFADHFV	SLC22A14	76	Q9Y267
MTMSVLGHYNNFFFA	RYR2	4726	Q92736
MLHFSFFVTIGDMDE	IFT140	776	Q96RY7
FTALSFFMGFMDSHR	NYNRIN	1091	Q9P2P1
HMFFIHFFTAMESIV	OR52E8	106	Q6IFG1
VQMFFLHSFSIMESA	OR52K1	101	Q8NGK4
AQMFFLHSFSIMESA	OR52K2	101	Q8NGK3
LIQMFFIHAFSSMES	OR52L1	116	Q8NGH7
LIQMFFTHAFSSMES	OR52L2P	116	Q8NGH6
AQMFFVHTFTGMESG	OR52N1	101	Q8NH53
MFHGGMNFEISFKFR	USH2A	1731	O75445
AFVTTFIMMPFASEF	TMEM225B	86	P0DP42
TMMFFSNFPFSWIRH	SLC38A6	356	Q8IZM9
VLMFMTLLHFDASFF	SURF4	166	O15260
ASFFAVMGASAAMVF	ATP6V0C	11	P27449
VMASAMSSSPIFFFF	GAFA1	11	Q96PS6
MTDMSILSFFEHFHI	VPS13C	3316	Q709C8
FVSAFVTAGHMRFIM	TRAPPC2	71	P0DI81
FVSAFVTAGHMRFIM	TRAPPC2B	71	P0DI82