Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium-dependent cysteine-type endopeptidase activity	CAPN9 CAPN11 CAPN15	8.11e-05	17	101	3	GO:0004198
GeneOntologyCellularComponent	acrosomal vesicle	CAPN11 CFAP65 HYAL3 MROH2B RAB2B SSH2 DKKL1	6.41e-05	206	101	7	GO:0001669
Domain	Calpain_cysteine_protease	CAPN9 CAPN11 CAPN15	4.60e-05	14	96	3	IPR022684
Domain	CysPc	CAPN9 CAPN11 CAPN15	5.73e-05	15	96	3	SM00230
Domain	Peptidase_C2_calpain_cat	CAPN9 CAPN11 CAPN15	5.73e-05	15	96	3	IPR001300
Domain	Peptidase_C2	CAPN9 CAPN11 CAPN15	5.73e-05	15	96	3	PF00648
Domain	CALPAIN_CAT	CAPN9 CAPN11 CAPN15	5.73e-05	15	96	3	PS50203
Domain	THIOL_PROTEASE_CYS	CAPN9 CAPN11 CAPN15	3.14e-04	26	96	3	PS00139
Domain	THIOL_PROTEASE_ASN	CAPN9 CAPN11 CAPN15	3.52e-04	27	96	3	PS00640
Domain	THIOL_PROTEASE_HIS	CAPN9 CAPN11 CAPN15	3.52e-04	27	96	3	PS00639
Domain	Pept_cys_AS	CAPN9 CAPN11 CAPN15	3.93e-04	28	96	3	IPR000169
Domain	APC_su10/DOC_dom	MYCBP2 HERC2	5.40e-04	7	96	2	IPR004939
Domain	DOC	MYCBP2 HERC2	5.40e-04	7	96	2	PS51284
Domain	APC10	MYCBP2 HERC2	5.40e-04	7	96	2	SM01337
Domain	ANAPC10	MYCBP2 HERC2	5.40e-04	7	96	2	PF03256
Domain	EF-hand_8	CAPN9 CAPN11 MICU2	7.02e-04	34	96	3	PF13833
Domain	DHC_N1	DNAH10 DYNC2H1	7.17e-04	8	96	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH10 DYNC2H1	7.17e-04	8	96	2	IPR013594
Domain	Calpain_III	CAPN9 CAPN11	1.67e-03	12	96	2	IPR022683
Domain	calpain_III	CAPN9 CAPN11	1.67e-03	12	96	2	SM00720
Domain	C2_III	CAPN9 CAPN11	1.67e-03	12	96	2	IPR033883
Domain	Calpain_domain_III	CAPN9 CAPN11	1.97e-03	13	96	2	IPR022682
Domain	Calpain_III	CAPN9 CAPN11	1.97e-03	13	96	2	PF01067
Domain	CUB	LRP12 MEGF8 LRP3	2.04e-03	49	96	3	PF00431
Domain	-	CNTN4 SDK2 MID2 MYCBP2 NRG2 CD86 SDK1 IL5RA PLXNA2 VSTM1	2.15e-03	663	96	10	2.60.40.10
Domain	CUB	LRP12 MEGF8 LRP3	2.17e-03	50	96	3	SM00042
Domain	Dynein_heavy_chain_D4_dom	DNAH10 DYNC2H1	2.29e-03	14	96	2	IPR024317
Domain	Dynein_HC_stalk	DNAH10 DYNC2H1	2.29e-03	14	96	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH10 DYNC2H1	2.29e-03	14	96	2	IPR013602
Domain	DHC_N2	DNAH10 DYNC2H1	2.29e-03	14	96	2	PF08393
Domain	MT	DNAH10 DYNC2H1	2.29e-03	14	96	2	PF12777
Domain	AAA_8	DNAH10 DYNC2H1	2.29e-03	14	96	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH10 DYNC2H1	2.29e-03	14	96	2	IPR011704
Domain	AAA_5	DNAH10 DYNC2H1	2.29e-03	14	96	2	PF07728
Domain	-	LRP12 MEGF8 LRP3	2.42e-03	52	96	3	2.60.120.290
Domain	CUB	LRP12 MEGF8 LRP3	2.56e-03	53	96	3	PS01180
Domain	DHC_fam	DNAH10 DYNC2H1	2.63e-03	15	96	2	IPR026983
Domain	Dynein_heavy_dom	DNAH10 DYNC2H1	2.63e-03	15	96	2	IPR004273
Domain	Dynein_heavy	DNAH10 DYNC2H1	2.63e-03	15	96	2	PF03028
Domain	CUB_dom	LRP12 MEGF8 LRP3	3.15e-03	57	96	3	IPR000859
Domain	Ig-like_fold	CNTN4 SDK2 MID2 MYCBP2 NRG2 CD86 SDK1 IL5RA PLXNA2 VSTM1	3.38e-03	706	96	10	IPR013783
Domain	Acyl_Trfase/lysoPLipase	PLA2G4E FASN	3.38e-03	17	96	2	IPR016035
Domain	FN3	CNTN4 SDK2 MID2 SDK1 IL5RA	3.65e-03	199	96	5	PS50853
Domain	FN3_dom	CNTN4 SDK2 MID2 SDK1 IL5RA	4.49e-03	209	96	5	IPR003961
Domain	RCC1	MYCBP2 HERC2	4.68e-03	20	96	2	PF00415
Domain	RHO	RHOBTB1 RHOBTB2	4.68e-03	20	96	2	PS51420
Pubmed	Regulator of G protein signaling 12 drives inflammatory arthritis by activating synovial fibroblasts through MYCBP2/KIF2A signaling.	MYCBP2 LTN1 HERC2	8.75e-07	7	103	3	36700049
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SYNE1 MED13L MEGF8 SGSM2 RHOBTB2 PDE4DIP KATNIP CAMSAP2 PLXNA2	3.59e-06	407	103	9	12693553
Pubmed	Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation.	NR4A1 ACOD1	8.69e-06	2	103	2	38329873
Pubmed	Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A2 formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).	CNTN4 PPARGC1B	8.69e-06	2	103	2	29258006
Pubmed	Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy.	SDK2 SDK1	8.69e-06	2	103	2	15213259
Pubmed	Definition of the critical domains required for homophilic targeting of mouse sidekick molecules.	SDK2 SDK1	8.69e-06	2	103	2	15703275
Pubmed	Architecture of cell-cell adhesion mediated by sidekicks.	SDK2 SDK1	8.69e-06	2	103	2	30150416
Pubmed	Pituitary NR4A1 is negatively regulated by thyroid hormone without direct binding of thyroid hormone receptors on the gene.	NR4A1 THRB	8.69e-06	2	103	2	28823847
Pubmed	Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina.	SDK2 SDK1	8.69e-06	2	103	2	12230981
Pubmed	Molecular basis of sidekick-mediated cell-cell adhesion and specificity.	SDK2 SDK1	8.69e-06	2	103	2	27644106
Pubmed	An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.	CNTN4 SDK2 SDK1 PLXNA2	1.76e-05	52	103	4	26633812
Pubmed	Lrp12/Mig13a reveals changing patterns of preplate neuronal polarity during corticogenesis that are absent in reeler mutant mice.	LRP12 RELN	2.60e-05	3	103	2	20439316
Pubmed	The Dictyostelium discoideum family of Rho-related proteins.	RHOBTB1 RHOBTB2	2.60e-05	3	103	2	11222756
Pubmed	Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin.	FLG PADI1	2.60e-05	3	103	2	15675958
Pubmed	Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis.	RHOBTB1 RHOBTB2	2.60e-05	3	103	2	27314390
Pubmed	An RNA-binding domain in the thyroid hormone receptor enhances transcriptional activation.	SRA1 THRB	2.60e-05	3	103	2	15180993
Pubmed	Single nucleotide polymorphisms in an Indian cohort and association of CNTN4, MMP2 and SNTB1 variants with oral cancer.	CNTN4 SNTB1	2.60e-05	3	103	2	28595731
Pubmed	Molecular Pathway of Microtubule Organization at the Golgi Apparatus.	PDE4DIP CAMSAP2	2.60e-05	3	103	2	27666745
Pubmed	Pathogenic variants of DYNC2H1, KIAA0556, and PTPN11 associated with hypothalamic hamartoma.	DYNC2H1 KATNIP	2.60e-05	3	103	2	31197031
Pubmed	Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse.	RHOBTB1 RHOBTB2	2.60e-05	3	103	2	12426103
Pubmed	Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis.	FLG PADI1	2.60e-05	3	103	2	26616205
Pubmed	Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction.	NR4A1 CD86	5.19e-05	4	103	2	30814730
Pubmed	Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD.	FAM201A MYCBP2 ACOD1	7.83e-05	28	103	3	25158072
Pubmed	Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism.	RHOBTB1 RHOBTB2	8.64e-05	5	103	2	18835386
Pubmed	The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges.	SDK2 SDK1	8.64e-05	5	103	2	34545809
Pubmed	Expression and Roles of the Immunoglobulin Superfamily Recognition Molecule Sidekick1 in Mouse Retina.	SDK2 SDK1	1.29e-04	6	103	2	30687002
Pubmed	Reporter-nanobody fusions (RANbodies) as versatile, small, sensitive immunohistochemical reagents.	SDK2 SDK1	1.29e-04	6	103	2	29440485
Pubmed	Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.	PPARGC1B THRB	1.29e-04	6	103	2	11733490
Pubmed	MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein.	RHOBTB1 RHOBTB2	1.29e-04	6	103	2	22709582
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SYNE1 RHOBTB1 RHOBTB2 LTN1	2.38e-04	101	103	4	9872452
Pubmed	Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region.	CD86 SLC14A2	2.40e-04	8	103	2	25279986
Pubmed	Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain.	RHOBTB1 RHOBTB2	2.40e-04	8	103	2	24923387
Pubmed	Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity.	CHAF1B CABIN1	2.40e-04	8	103	2	22195966
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ENTPD4 HERC2 MICU2 CABIN1	2.66e-04	104	103	4	9205841
Pubmed	A new paradigm for MAPK: structural interactions of hERK1 with mitochondria in HeLa cells.	FASN PRDX3	3.08e-04	9	103	2	19847302
Pubmed	RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins.	SGSM2 RAB2B	3.08e-04	9	103	2	21808068
Pubmed	Functional and comparative genomic analysis of the piebald deletion region of mouse chromosome 14.	MYCBP2 ACOD1	3.85e-04	10	103	2	12160731
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CNTN4 CHAF1B RELN MYCBP2 SYNE1 MED13L UBA7 P4HTM SGSM2 PDE4DIP HERC2 CABIN1	4.25e-04	1285	103	12	35914814
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PITPNM2 MYCBP2 TTYH3 PIGG MED13L FASN MEGF8 SGSM2 LRP3 HERC2 CABIN1	4.40e-04	1105	103	11	35748872
Pubmed	A forward genetic screen in mice identifies mutants with abnormal cortical patterning.	RELN MYCBP2	4.69e-04	11	103	2	23968836
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CNTN4 MYCBP2 SYNE1 PELP1 PDE4DIP SSH2 HERC2 WDR1 CABIN1 CAMSAP2	5.85e-04	963	103	10	28671696
Pubmed	Myc-dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor-2.	ACOD1 FASN	6.63e-04	13	103	2	31545012
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CNTN4 DYNC2H1 GRAMD1A TTYH3 RHOBTB1 LTN1 SSH2	6.77e-04	493	103	7	15368895
Pubmed	Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.	CEP128 PPT2 IL5RA	7.64e-04	60	103	3	23362303
Pubmed	SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.	RELN SYNE1	7.72e-04	14	103	2	19874786
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH10 DYNC2H1	7.72e-04	14	103	2	9373155
Pubmed	Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice.	CNTN4 IL5RA	7.72e-04	14	103	2	16964447
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	LRP12 MYCBP2 GRAMD1A PIGG PLA2R1 P4HTM MEGF8 HYAL3 PRDX3 CDIPT LTN1	8.73e-04	1201	103	11	35696571
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	MID2 DYNC2H1 PACSIN3 TTYH3 SUCNR1 FASN MEGF8 PLPP1 ASL WDR1	8.80e-04	1016	103	10	19056867
Pubmed	Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity.	CNTN4 PPT2 ASL RAB2B SSH2 WDR1	8.84e-04	374	103	6	23824909
Pubmed	FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation.	MYCBP2 MED13L	8.89e-04	15	103	2	31285543
Pubmed	TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77.	NR4A1 PELP1	8.89e-04	15	103	2	19321449
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	CNTN4 MYCBP2 ENTPD4 FREM1 ZNF100 RHOBTB1 PLPP1 SAMD11 LTN1 HERC2 ZNF415	9.59e-04	1215	103	11	15146197
Pubmed	TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN.	FLG SDK2 MYCBP2 FASN PRDX3 PDE4DIP	9.86e-04	382	103	6	37249651
Pubmed	Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.	RELN PLXNA2	1.15e-03	17	103	2	11683995
Pubmed	Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness.	CNTN4 SYNE1	1.15e-03	17	103	2	17903302
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	LRP12 SYNE1 PACSIN3 ABT1 TTYH3 PIGG HERC2 KIF13A	1.36e-03	719	103	8	35337019
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	DNAH10 SYNE1 CCDC168 FAM13B	1.60e-03	168	103	4	30631154
Pubmed	The DNA sequence and analysis of human chromosome 13.	SERPINE3 MYCBP2 CCDC168 MICU2	1.67e-03	170	103	4	15057823
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	FLG CHAF1B DYNC2H1 SYNE1 FASN RHOBTB1 PRDX3 KIF13A	1.83e-03	754	103	8	35906200
Pubmed	The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division.	MID2 CEP128	1.93e-03	22	103	2	26748699
Pubmed	Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.	SDK2 RAB2B HERC2	2.02e-03	84	103	3	15203218
Pubmed	Sidekick 2 directs formation of a retinal circuit that detects differential motion.	SDK2 SDK1	2.11e-03	23	103	2	26287463
Pubmed	Functional genetic analysis of mouse chromosome 11.	FREM1 WDR1	2.11e-03	23	103	2	12955145
Pubmed	Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity.	CCDC168 PDE4DIP	2.11e-03	23	103	2	22792062
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	DNAH10 DYNC2H1 SYNE1 SSH2	2.36e-03	187	103	4	26460568
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	LRP12 CHAF1B PLPP1 LTN1 HERC2	2.44e-03	313	103	5	38270169
Pubmed	Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.	PITPNM2 MYCBP2	2.49e-03	25	103	2	12522145
Pubmed	A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.	SDK2 SDK1 PLXNA2	2.54e-03	91	103	3	28558017
Pubmed	A comprehensive resource of interacting protein regions for refining human transcription factor networks.	NR4A1 PELP1 LTN1 CAMSAP2	2.55e-03	191	103	4	20195357
Pubmed	An approach based on a genome-wide association study reveals candidate loci for narcolepsy.	SRA1 NR4A1 PPARGC1B THRB	2.65e-03	193	103	4	20677014
Pubmed	The structural role of radial glial endfeet in confining spinal motor neuron somata is controlled by the Reelin and Notch pathways.	RELN PLXNA2	2.69e-03	26	103	2	23988635
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	MYCBP2 LTN1 HERC2	2.87e-03	95	103	3	29643511
Interaction	OAZ1 interactions	SRA1 MYCBP2 FASN OAZ3 CAMSAP2	1.14e-06	38	99	5	int:OAZ1
GeneFamily	C2 domain containing\|Calpains	CAPN9 CAPN11 CAPN15	2.55e-05	15	71	3	975
GeneFamily	Fibronectin type III domain containing	CNTN4 SDK2 MID2 PTPRQ SDK1	4.15e-04	160	71	5	555
GeneFamily	Immunoglobulin like domain containing	CNTN4 SDK2 CD86 SDK1 VSTM1	9.69e-04	193	71	5	594
GeneFamily	Low density lipoprotein receptors	LRP12 LRP3	1.15e-03	13	71	2	634
GeneFamily	Rho family GTPases	RHOBTB1 RHOBTB2	2.76e-03	20	71	2	390
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	CNTN4 SDK2 NRG2 SDK1	3.70e-03	161	71	4	593
ToppCell	renal_medulla_nuclei-Adult_normal_reference\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	PITPNM2 NR4A1 THRB PLPP1 PDE4DIP SLC14A2 PLXNA2	3.02e-07	190	103	7	f1363f7806cfc4f14fbc1b0e8dac2de813a88eee
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CNTN4 SDK2 MYCBP2 DYNC2H1 SYNE1 FREM1 LRP3	4.12e-07	199	103	7	a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCell	droplet-Marrow-nan-24m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHAF1B NIBAN3 PLPP1 CD86 PRDX3 IL5RA	3.11e-06	173	103	6	35dc897e06f905419d44093a92170d2cec35dd51
ToppCell	droplet-Marrow-nan-24m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHAF1B NIBAN3 PLPP1 CD86 PRDX3 IL5RA	3.11e-06	173	103	6	37825d0dda028cf677ff6ff16ea58bff75cb25a7
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CNTN4 SDK2 SYNE1 FREM1 PLPP1 SDK1	6.01e-06	194	103	6	60622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FLG RELN SYNE1 PLA2R1 SAMD11 PTPRQ	6.01e-06	194	103	6	1374600957c7d7f0b05fd2c1186f521b9096d4ef
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_2\|390C / Donor, Lineage, Cell class and subclass (all cells)	NRG2 TTYH3 PIGG SUCNR1 GDF11	3.03e-05	155	103	5	15bacd06cc2b02b13c85bb71c5b758e5ff613e80
ToppCell	severe_influenza-CD8+_T_naive\|severe_influenza / disease group, cell group and cell class (v2)	PITPNM2 ZNF57 ZNF14 PLPP1 ZNF764	3.64e-05	161	103	5	82196139cdbbd70a36957a87bc9ac6d02575da3f
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SERPINE3 NRG2 SGSM2 HYAL3 SLC14A2	3.75e-05	162	103	5	ca30d9bf61f4133566fdc91c7996e130ea554d01
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Papillary_Renal_Cell_Carcinoma-7\|TCGA-Kidney / Sample_Type by Project: Shred V9	RELN CFAP65 P4HTM KATNIP SSH2	4.21e-05	166	103	5	b545de32578047c9ca422354b8992f2d9c9e1cc7
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Myeloid-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRAMD1A ACOD1 THRB LTN1 KATNIP	4.71e-05	170	103	5	f3d5678669dcaed1836014cea543758b7ccc6b46
ToppCell	NS-critical-d_0-4-Epithelial-FOXN4+\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CHAF1B FAM201A PLA2R1 LRP3 SNTB1	4.98e-05	172	103	5	a00bb44d33658cb3a98accd6b60f3ce964c425b4
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SERPINE3 COQ6 PPARGC1B HYAL3 IL5RA	5.12e-05	173	103	5	8bffd512a4e561e23cc04478e2ca6fd5d3771fe4
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SERPINE3 COQ6 PPARGC1B HYAL3 IL5RA	5.12e-05	173	103	5	3e3c61468e703330788a10d850ef41a85680f86d
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NIBAN3 ARHGAP22 P4HTM PDE4DIP DKKL1	5.26e-05	174	103	5	7be0c6248e77f2d0260b852b01e17892f7828f1b
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 DYNC2H1 CFAP65 SDK1 DKKL1	6.02e-05	179	103	5	5e5f1cdf4aa66868d45b74ba91e20e848a3cbaff
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN DNAH10 FREM1 PTPRQ SDK1	6.86e-05	184	103	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	CNTN4 LRP12 MYCBP2 MED13L FREM1	6.86e-05	184	103	5	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN DNAH10 FREM1 PTPRQ SDK1	6.86e-05	184	103	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RELN DNAH10 FREM1 PTPRQ SDK1	6.86e-05	184	103	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Skin-nan-18m-Epithelial-Basal_IFE\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WSB1 SYNE1 NR4A1 RHOBTB1 SSH2	7.78e-05	189	103	5	6c71e81373cb7822de23c193a6350b6df9f567bc
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	WSB1 DYNC2H1 FREM1 SLC14A2 SDK1	7.78e-05	189	103	5	8ff3c3232eff9de4b5c9b22ecb82bc509d773f58
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	WSB1 NR4A1 FREM1 SNTB1 VWA5B1	7.78e-05	189	103	5	a9864873b19ab3e60acf11f288fa7275badc2e42
ToppCell	Adult\|World / Lineage, Cell type, age group and donor	ARHGAP22 FASN RHOBTB2 PDE4DIP SNTB1	7.78e-05	189	103	5	5cd285bfad973125d46d704fec18b21266a63379
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	WSB1 DYNC2H1 FREM1 SLC14A2 SDK1	7.98e-05	190	103	5	4836ea19308d2a96694f12ab0653b7ce7b101d2f
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH10 DYNC2H1 CFAP65 SDK1 PLXNA2	8.59e-05	193	103	5	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CNTN4 SDK2 FREM1 PLPP1 SDK1	8.80e-05	194	103	5	89b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLG RELN SYNE1 PLA2R1 PTPRQ	9.23e-05	196	103	5	545d2e4469924d333e3f655f559c899fa1260196
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SDK2 DYNC2H1 SYNE1 FREM1 PLPP1	9.92e-05	199	103	5	30d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CNTN4 SDK2 SYNE1 FASN SDK1	9.92e-05	199	103	5	8b86c69aaf60feff53aa782559cfece7342a23de
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CNTN4 DYNC2H1 SYNE1 FREM1 SDK1	1.02e-04	200	103	5	9b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RELN SDK2 SYNE1 LGI4 PDE4DIP	1.02e-04	200	103	5	b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RELN SDK2 SYNE1 LGI4 PDE4DIP	1.02e-04	200	103	5	f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	CNTN4 MYCBP2 SYNE1 THRB DPY19L2P1	1.02e-04	200	103	5	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Sepsis-ICU-SEP-Lymphocyte-T/NK-dn_T\|ICU-SEP / Disease, condition lineage and cell class	FASN ZNF764 TRAPPC10 MICU2 CAMSAP2	1.02e-04	200	103	5	9ee3e18dc429b9c472e3e366d9bfdbb150daa369
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-GABAergic_neurons\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	RELN SDK2 MYCBP2 THRB PDE4DIP	1.02e-04	200	103	5	c6bbd33bca86ac7a76a7ba704b3e141237d04549
Disease	developmental and epileptic encephalopathy 64 (implicated_via_orthology)	RHOBTB1 RHOBTB2	1.14e-05	2	100	2	DOID:0070375 (implicated_via_orthology)
Disease	obesity (implicated_via_orthology)	CAPN9 SDK2 DNAH10 MED13L CAPN11 SDK1	9.41e-05	215	100	6	DOID:9970 (implicated_via_orthology)
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CAPN9 CAPN11 SNTB1	2.49e-04	36	100	3	DOID:11723 (implicated_via_orthology)
Disease	urate measurement, bone density	CNTN4 CHAF1B SYNE1 ENTPD4 FREM1 ARHGAP22 RHOBTB1 RHOBTB2 CABIN1	2.59e-04	619	100	9	EFO_0003923, EFO_0004531
Disease	FVC change measurement, response to placebo	RELN KATNIP	8.66e-04	13	100	2	EFO_0008344, EFO_0010339
Disease	Tourette syndrome, schizophrenia	PITPNM2 DNAH10	1.68e-03	18	100	2	EFO_0004895, MONDO_0005090
Disease	neoplasm of mature B-cells	CD86 SLC14A2	2.08e-03	20	100	2	EFO_0000096
Disease	small cell lung carcinoma	DYNC2H1 ABT1 VSTM1	2.57e-03	80	100	3	EFO_0000702
Disease	susceptibility to Mycobacterium tuberculosis infection measurement	CNTN4 THRB SDK1	3.15e-03	86	100	3	EFO_0008407
Disease	Involutional paraphrenia	RELN NR4A1	3.24e-03	25	100	2	C1571983
Disease	Psychosis, Involutional	RELN NR4A1	3.24e-03	25	100	2	C1571984
Disease	Involutional Depression	RELN NR4A1	3.24e-03	25	100	2	C0011574

Protein segments in the cluster

Peptide	Gene	Start	Entry
SSEHLSVADATWLAL	CASTOR3	76	Q8NAP1
RGLDHSSSWQDHSRF	CEP128	1036	Q6ZU80
FHSTTWSRIRAHSLN	AKAP10	161	O43572
VSNIHYHTLSDISWS	CHAF1B	341	Q13112
VTHDHSLDIVFTWSF	CNTN4	521	Q8IWV2
LSSLVWSTSHEHAAE	COQ6	266	Q9Y2Z9
HEASSWADSSRHSLV	FLG	2211	P20930
FVHSTERSEFWSALL	CAPN11	201	Q9UMQ6
NLERSHWLTSYTHDF	C7orf31	271	Q8N865
TSFDSDSWTLRLHNL	CD86	86	P42081
DVASHWLHLHSSVVR	CDIPT	101	O14735
LERTAHTFESWHSLA	GRAMD1A	636	Q96CP6
AESSELVRNSHHTWL	P4HTM	266	Q9NXG6
RDNHRSAEPDLTHSW	PADI1	156	Q9ULC6
HLTSWLEDARQHSSS	RAB2B	96	Q8WUD1
LSHSLETVSSHSVWS	NIBAN3	676	Q86XR2
VSSESHFSERWTLLS	LTN1	761	O94822
DWIDSILAFSRSLHS	NR4A1	481	P22736
FRDHRATWSVFHTLR	CAPN15	526	O75808
TSAHSRSLLHLSSWR	FAM201A	76	Q5SY85
DRHFSHLSSLEWEMT	DPY19L2P1	126	Q6NXN4
LDFHFRLTSQTSAHW	OAZ3	121	Q9UMX2
ISSQDHIWIRFHSDD	LRP12	131	Q9Y561
EALVRSATVHSWPHS	MED13L	1296	Q71F56
WTLLLFFFHTHSTVT	GPR179	606	Q6PRD1
VAASIASTSWRHFAE	HERC2	1106	O95714
EQEHTLHESWSSLSA	KATNIP	891	O60303
LHESWSSLSAFDRSH	KATNIP	896	O60303
HWILSHAVALTRDSE	ASL	171	P04424
FHNISSWDNSSIHSR	CFAP65	1416	Q6ZU64
ASHHEEIWSANSLAA	FAM13B	161	Q9NYF5
TDSFHTELHPRVAFW	DKKL1	156	Q9UK85
FHSENRDWTFNHLTV	PLXNA2	41	O75051
HHAESDSSTLTLWLR	NUDT6	116	P53370
LRHWHSSHLLRATSD	PCDHGA9	716	Q9Y5G4
SMSLDQSLEFHSWHT	FAM205A	146	Q6ZU69
HESHTWSLERSESLT	NRG2	516	O14511
THLLDHTRPISSFTW	FREM1	346	Q5H8C1
NSTELFHVDRHVWTT	MEGF8	421	Q7Z7M0
ARDHVWIFFHSDASS	LRP3	131	O75074
LITTTSWESFHFIGH	METTL21EP	66	A6NDL7
FHVRESGWEHVSRSD	PSMB11	226	A5LHX3
HLFHASYWESTDVVS	PITPNM2	941	Q9BZ72
HTESWEQELHSLLAS	PELP1	256	Q8IZL8
LEFSTNHGRSWSLLH	RELN	591	P78509
AFNISTHSFSLHWSL	PTPRQ	16	Q9UMZ3
ISHTAWHSNRTLYET	PPT2	281	Q9UMR5
LDAWNLSHTSEEFFH	PLA2G4E	586	Q3MJ16
LSHTSEEFFHRWTRE	PLA2G4E	591	Q3MJ16
DNTHRAHALFSLAWF	DYNC2H1	3856	Q8NCM8
FTWSHLSEHLAFERQ	ABT1	151	Q9ULW3
HSLLASSWASAELHA	IL5RA	106	Q01344
VLSVYHSWRRHSTSL	CABIN1	511	Q9Y6J0
IELHSRSGHWQSIDF	GDF11	226	O95390
DLSLSSSEEECWHLH	HYAL3	321	O43820
NVLLDHWTHRSDSAF	FBXO47	221	Q5MNV8
AHLSTHWVADAAASV	ACOD1	276	A6NK06
ARSDLFRKNSSHWDH	CCDC168	6946	Q8NDH2
ANSRDTSFEQHVLWH	FASN	1721	P49327
RLVFLHSADHNEFWS	CAPN9	156	O14815
FEADLFTTRHISHWV	DNAH10	4446	Q8IVF4
SHSHAVVLSWVRPFD	SDK1	681	Q7Z5N4
RWALHSASVSHNASS	SDK2	1446	Q58EX2
ASVDAITIHSHLWQT	CAMSAP2	1461	Q08AD1
WHAFFTAAERLSALH	PACSIN3	81	Q9UKS6
ATASWDSSVHDSVHL	KIF13A	1226	Q9H1H9
RWVGHSLLHVFSTEF	RPUSD2	156	Q8IZ73
HLFRAETSRDLSHWT	SNTB1	411	Q13884
DSAALSDLHWHDRSA	SYNE1	8231	Q8NF91
SDLHWHDRSADSLLS	SYNE1	8236	Q8NF91
QSLHAWHRDTDAEAL	LGI4	356	Q8N135
EAFRASHTHWRGVSF	ENTPD4	546	Q9Y227
SRVSDYKHHWSDVLT	PLPP1	216	O14494
WHHSRVSVAARDGSF	MICU2	51	Q8IYU8
VSVSLRLWDTFGDHH	RHOBTB2	76	Q9BYZ6
HHSKASWAEFSILRE	PPARGC1B	331	Q86YN6
WAARHISSEHFVLFI	SGSM2	936	O43147
VHTHWDVNISFREAS	SAMD11	86	Q96NU1
QTTSLHDILWHFVAS	MYCBP2	3586	O75592
AVSVDSHFSHLAWIN	PRDX3	131	P30048
SLAWLDEHTLVTTSH	WDR1	581	O75083
VSVSLRLWDTFGDHH	RHOBTB1	76	O94844
ILWILHTHSFTFFTS	MROH2B	1501	Q7Z745
HTHSFTFFTSTWEVI	MROH2B	1506	Q7Z745
SWLHSDLLTIHSAHE	PLA2R1	841	Q13018
DSSARSSLHTDWALE	ARHGAP22	536	Q7Z5H3
SFSRSSALIQHWRVH	ZNF132	411	P52740
AFNWFSTLTTHRRIH	ZNF100	241	Q8IYN0
LWRSHSDSDLSDHHE	SSH2	456	Q76I76
STAEHTLQWARHEFE	UBA7	606	P41226
GHILTTLDHWSSRCE	TOMT	96	Q8WZ04
LSSHRWDAADDIHRS	SRA1	156	Q9HD15
TTWTSSIFHLDHDDV	THRB	61	P10828
HLTASTIHLWTTSLR	SERPINE3	276	A8MV23
RHNFKSLTSFSRWAH	SUCNR1	311	Q9BXA5
TASHEWSESSEHLQL	VSTM1	101	Q6UX27
WLSSVVDHFHSSLGD	ZUP1	341	Q96AP4
FSQTSSLARHWRIHT	ZNF415	441	Q09FC8
KAFSWHSSVRIHERT	ZNF491	166	Q8N8L2
WSSTFREHVRIHTQE	ZNF57	431	Q68EA5
DRWVRSVSFSHDGLH	WSB1	311	Q9Y6I7
HSAHSSQLDADSWIE	TRAPPC10	1171	P48553
HDTITVHWISDDEFS	MID2	416	Q9UJV3
VLWASHLVHFLSSET	PIGG	896	Q5H8A4
HRLPHFDLSWEATSS	TTYH3	16	Q9C0H2
VLSKHRSVFHIEWSS	SLC14A2	471	Q15849
WRSTLVEHVYSHTGE	ZNF764	186	Q96H86
AQDADLWSETFHHLA	VWA5B1	841	Q5TIE3
SFSWSISLRLHERTH	ZNF14	371	P17017
HHALEESASLLTMFW	PDE4DIP	2241	Q5VU43