Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetylglucosaminyltransferase activity	GCNT7 MFNG B3GNT7	3.44e-05	47	27	3	GO:0008375
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2C PRDM7	3.30e-04	20	27	2	GO:0042800
GeneOntologyMolecularFunction	protein methyltransferase activity	KMT2C MGMT PRDM7	3.56e-04	103	27	3	GO:0008276
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	GCNT7 MFNG B3GNT7	1.13e-03	153	27	3	GO:0008194
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	KMT2C PRDM7	1.61e-03	44	27	2	GO:0140938
GeneOntologyMolecularFunction	hexosyltransferase activity	GCNT7 MFNG B3GNT7	2.82e-03	211	27	3	GO:0016758
GeneOntologyMolecularFunction	methyltransferase activity	KMT2C MGMT PRDM7	2.90e-03	213	27	3	GO:0008168
GeneOntologyMolecularFunction	transferase activity, transferring one-carbon groups	KMT2C MGMT PRDM7	3.34e-03	224	27	3	GO:0016741
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	PLEKHG6 MYCBP2 HPS1	3.64e-03	231	27	3	GO:0005085
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	KMT2C PRDM7	3.80e-03	68	27	2	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	KMT2C PRDM7	3.91e-03	69	27	2	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	KMT2C PRDM7	4.13e-03	71	27	2	GO:0042054
GeneOntologyMolecularFunction	GTPase regulator activity	PLEKHG6 MYCBP2 ARHGAP36 HPS1	4.53e-03	507	27	4	GO:0030695
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	PLEKHG6 MYCBP2 ARHGAP36 HPS1	4.53e-03	507	27	4	GO:0060589
Domain	APC_su10/DOC_dom	CUL9 MYCBP2	4.21e-05	7	27	2	IPR004939
Domain	APC10	CUL9 MYCBP2	4.21e-05	7	27	2	SM01337
Domain	DOC	CUL9 MYCBP2	4.21e-05	7	27	2	PS51284
Domain	ANAPC10	CUL9 MYCBP2	4.21e-05	7	27	2	PF03256
Domain	SET	KMT2C PRDM7	2.00e-03	46	27	2	SM00317
Domain	-	HSPG2 ALK	2.00e-03	46	27	2	4.10.400.10
Domain	LDLRA_1	HSPG2 ALK	2.18e-03	48	27	2	PS01209
Domain	LDrepeatLR_classA_rpt	HSPG2 ALK	2.27e-03	49	27	2	IPR002172
Domain	LDLa	HSPG2 ALK	2.27e-03	49	27	2	SM00192
Domain	LDLRA_2	HSPG2 ALK	2.27e-03	49	27	2	PS50068
Domain	SET_dom	KMT2C PRDM7	2.36e-03	50	27	2	IPR001214
Domain	SET	KMT2C PRDM7	2.36e-03	50	27	2	PS50280
Domain	Ig_I-set	IGSF10 HSPG2 ADAMTSL3	2.53e-03	190	27	3	IPR013098
Domain	I-set	IGSF10 HSPG2 ADAMTSL3	2.53e-03	190	27	3	PF07679
Domain	IGc2	IGSF10 HSPG2 ADAMTSL3	4.60e-03	235	27	3	SM00408
Domain	Ig_sub2	IGSF10 HSPG2 ADAMTSL3	4.60e-03	235	27	3	IPR003598
Domain	-	CUL9 MYCBP2	4.96e-03	73	27	2	2.60.120.260
Domain	IGv	IGSF10 HSPG2	5.23e-03	75	27	2	SM00406
Domain	Galactose-bd-like	CUL9 MYCBP2	8.11e-03	94	27	2	IPR008979
Domain	ZF_RING_2	CUL9 KMT2C MYCBP2	8.86e-03	298	27	3	PS50089
Domain	RING	CUL9 KMT2C MYCBP2	9.44e-03	305	27	3	SM00184
Domain	Znf_RING	CUL9 KMT2C MYCBP2	1.13e-02	326	27	3	IPR001841
Domain	ARM-type_fold	CUL9 VEPH1 USP24	1.26e-02	339	27	3	IPR016024
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NHSL1 CUL9 HSPG2 KMT2C MYCBP2 MFHAS1 SEC16A	2.11e-05	1105	28	7	35748872
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	CUL9 NRDC MYCBP2 USP24	2.45e-05	212	28	4	33853758
Pubmed	Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.	CUL9 NRDC	5.65e-05	14	28	2	22653443
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	CUL9 SET USP24 SEC16A	7.43e-05	282	28	4	23667531
Pubmed	Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.	MYCBP2 ALK	8.44e-05	17	28	2	19398581
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CUL9 FMR1 MYCBP2 USP24 SEC16A	1.58e-04	653	28	5	22586326
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	KMT2C SET TCAF1 NRDC HPS1 SEC16A	1.89e-04	1084	28	6	11544199
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	HSPG2 SET FMR1 MYCBP2	6.43e-04	497	28	4	23414517
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	SET TCAF1 USP24 SEC16A	6.47e-04	498	28	4	36634849
Pubmed	IKK-Mediated Regulation of the COP9 Signalosome via Phosphorylation of CSN5.	TCAF1 NRDC USP24	7.37e-04	221	28	3	31950832
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	SET CCDC59 FMR1 MFHAS1 SEC16A	7.67e-04	922	28	5	27609421
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	KMT2C MYCBP2 SEC16A	7.77e-04	225	28	3	12168954
Cytoband	Ensembl 112 genes in cytogenetic band chr1p32	NRDC USP24	4.04e-03	155	28	2	chr1p32
Cytoband	Ensembl 112 genes in cytogenetic band chr3q25	IGSF10 VEPH1	5.40e-03	180	28	2	chr3q25
GeneFamily	Beta 3-glycosyltransferases	MFNG B3GNT7	2.27e-04	24	17	2	426
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	IGSF10 HSPG2 ADAMTSL3	4.30e-04	161	17	3	593
GeneFamily	Immunoglobulin like domain containing	HSPG2 ADAMTSL3	1.39e-02	193	17	2	594
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG6 VEPH1	1.57e-02	206	17	2	682
Disease	Brain Tumor, Primary	MGMT ALK	4.50e-04	33	28	2	C0750974
Disease	Primary malignant neoplasm of brain	MGMT ALK	4.50e-04	33	28	2	C0750979
Disease	Recurrent Brain Neoplasm	MGMT ALK	4.50e-04	33	28	2	C0750977
Disease	Neoplasms, Intracranial	MGMT ALK	4.50e-04	33	28	2	C1527390
Disease	Benign neoplasm of brain, unspecified	MGMT ALK	4.50e-04	33	28	2	C0496899
Disease	granulocyte colony-stimulating factor measurement	SLC5A8 ALK	4.78e-04	34	28	2	EFO_0008142
Disease	anthropometric measurement	MGMT ADAMTSL3 MYCBP2	5.35e-04	168	28	3	EFO_0004302
Disease	Malignant neoplasm of brain	MGMT ALK	5.98e-04	38	28	2	C0153633
Disease	Brain Neoplasms	MGMT ALK	6.30e-04	39	28	2	C0006118
Disease	oral microbiome measurement	KMT2C NRDC	7.30e-04	42	28	2	EFO_0801229
Disease	esophagus squamous cell carcinoma (is_implicated_in)	KMT2C MGMT	8.38e-04	45	28	2	DOID:3748 (is_implicated_in)
Disease	response to cisplatin	NHSL1 CCDC59	1.08e-03	51	28	2	GO_0072718
Disease	very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio	MFHAS1 USP24 SEC16A	1.20e-03	222	28	3	EFO_0008317, EFO_0020943
Disease	triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	MFHAS1 USP24 SEC16A	1.24e-03	225	28	3	EFO_0008317, EFO_0020947
Disease	Necrosis	SET MGMT	1.25e-03	55	28	2	C0027540
Disease	very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	MFHAS1 USP24 SEC16A	1.97e-03	264	28	3	EFO_0008317, EFO_0020944
Disease	functional brain measurement	HSPG2 HPS1	2.75e-03	82	28	2	EFO_0007849
Disease	Glioma	MGMT ALK	3.09e-03	87	28	2	C0017638
Disease	cortical thickness	NHSL1 CUL9 HSPG2 ADAMTSL3 MYCBP2	3.61e-03	1113	28	5	EFO_0004840
Disease	Squamous cell carcinoma of esophagus	KMT2C MGMT	3.67e-03	95	28	2	C0279626

Protein segments in the cluster

Peptide	Gene	Start	Entry
QPSTFIVPFREQAWQ	HSPG2	1051	P98160
NWDVLFQVPPHIQRQ	ARHGAP36	421	Q6ZRI8
QHWQPENVNQAFTRP	KMT2C	2421	Q8NEZ4
RSWQVLEELHFQPPQ	MFHAS1	661	Q9Y4C4
HPVFQQESFTRQVLW	MGMT	86	P16455
WHQQENVFLPTTRPP	NHSL1	86	Q5SYE7
QWNFSQTPIEHVFPV	FAM214A	186	Q32MH5
QEPQPWIQIMFLFQQ	VEPH1	611	Q14D04
EQQETNPLFHAFVQW	PLEKHG6	276	Q3KR16
AFENNWQPDRQIPFH	FMR1	31	Q06787
RKIPWQQNFVNNHNP	IGSF10	1201	Q6WRI0
RPWDQAQHFTNPAPF	IGF2-AS	111	Q6U949
RQAEVPIEPHWHFQQ	GCNT7	406	Q6ZNI0
FRQSNNGIPPVQVFW	CUL9	406	Q8IWT3
PPDLAQRVQLWEHFQ	HPS1	136	Q92902
THQPWFQVLEPQFRQ	B3GNT7	96	Q8NFL0
RWDQPPHPQIQTFFS	NKG7	116	Q16617
PQPHNRTRLVQFWFA	MFNG	181	O00587
RNQQRQEWEFPPHTT	TCAF1	761	Q9Y4C2
PHAVWPFQVKNFSVN	PRDM7	421	Q9NQW5
IPNFWVTTFVNHPQV	SET	91	Q01105
RLNFWNFNPNPLQRH	SLC5A8	226	Q8N695
NFNPNPLQRHTFWTI	SLC5A8	231	Q8N695
NVRQKTWRPNHPQAF	CCDC59	31	Q9P031
ERNFQWPVLAFVIQH	MYCBP2	3536	O75592
WQHQPEDRPNFAIIL	ALK	1366	Q9UM73
TFRQNPRIVNHWASP	SEC16A	301	O15027
TITWALPPQQQHYRV	NRDC	441	O43847
NPQFVWVVPALRQLH	USP24	626	Q9UPU5
YQPISHQWRQTDFFP	ADAMTSL3	336	P82987