Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II CTD heptapeptide repeat kinase activity	CCNK BRD4	5.68e-05	10	23	2	GO:0008353
GeneOntologyMolecularFunction	RNA polymerase II CTD heptapeptide repeat modifying activity	CCNK BRD4	3.16e-04	23	23	2	GO:0140994
GeneOntologyMolecularFunction	methyl-CpG binding	CDX1 CDX2	5.78e-04	31	23	2	GO:0008327
GeneOntologyMolecularFunction	structural constituent of skin epidermis	SPRR1A SPRR1B	1.11e-03	43	23	2	GO:0030280
GeneOntologyMolecularFunction	double-stranded RNA binding	DHX15 STAU2	3.61e-03	78	23	2	GO:0003725
GeneOntologyBiologicalProcess	regulation of somitogenesis	CDX1 CDX2	2.49e-05	7	23	2	GO:0014807
GeneOntologyBiologicalProcess	keratinization	SPRR1A SPRR1B SPRR3	1.21e-04	87	23	3	GO:0031424
GeneOntologyBiologicalProcess	regulation of transcription elongation by RNA polymerase II	CCNK NELFA BRD4	1.47e-04	93	23	3	GO:0034243
GeneOntologyBiologicalProcess	regulation of DNA-templated transcription elongation	CCNK NELFA BRD4	2.11e-04	105	23	3	GO:0032784
GeneOntologyBiologicalProcess	transcription elongation by RNA polymerase II	CCNK NELFA BRD4	3.69e-04	127	23	3	GO:0006368
GeneOntologyBiologicalProcess	peptide cross-linking	SPRR1A SPRR1B	4.10e-04	27	23	2	GO:0018149
GeneOntologyBiologicalProcess	DNA-templated transcription elongation	CCNK NELFA BRD4	5.33e-04	144	23	3	GO:0006354
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	ITGA8 CCNK NELFA ZFHX3 CDX1 BRD4 CDX2	5.84e-04	1390	23	7	GO:0045944
GeneOntologyCellularComponent	transcription elongation factor complex	CCNK NELFA BRD4 AFF2	3.94e-07	56	23	4	GO:0008023
GeneOntologyCellularComponent	cyclin/CDK positive transcription elongation factor complex	CCNK BRD4	4.15e-05	9	23	2	GO:0008024
GeneOntologyCellularComponent	cornified envelope	SPRR1A SPRR1B SPRR3	5.81e-05	69	23	3	GO:0001533
GeneOntologyCellularComponent	nuclear cyclin-dependent protein kinase holoenzyme complex	CCNK BRD4	1.75e-04	18	23	2	GO:0019908
GeneOntologyCellularComponent	carboxy-terminal domain protein kinase complex	CCNK BRD4	3.15e-04	24	23	2	GO:0032806
GeneOntologyCellularComponent	nuclear body	DHX15 PRPF40B ATXN2L NELFA ZFHX3 AFF2	3.43e-04	903	23	6	GO:0016604
GeneOntologyCellularComponent	nuclear protein-containing complex	DHX15 PRPF40B CCNK NELFA CPSF4 BRD4 AFF2	5.09e-04	1377	23	7	GO:0140513
GeneOntologyCellularComponent	nuclear speck	DHX15 PRPF40B ATXN2L AFF2	1.16e-03	431	23	4	GO:0016607
GeneOntologyCellularComponent	cyclin-dependent protein kinase holoenzyme complex	CCNK BRD4	2.04e-03	61	23	2	GO:0000307
GeneOntologyCellularComponent	condensed nuclear chromosome	BRD4 CDX2	4.47e-03	91	23	2	GO:0000794
GeneOntologyCellularComponent	cytoplasmic stress granule	ATXN2L STAU2	4.96e-03	96	23	2	GO:0010494
GeneOntologyCellularComponent	U2-type spliceosomal complex	DHX15 PRPF40B	5.06e-03	97	23	2	GO:0005684
Domain	Cornifin	SPRR1A SPRR1B SPRR3	6.52e-09	4	23	3	IPR003302
Domain	Caudal_act	CDX1 CDX2	4.35e-06	3	23	2	PF04731
Domain	Caudal_activation_dom	CDX1 CDX2	4.35e-06	3	23	2	IPR006820
Domain	SPRR/LCE	SPRR1A SPRR1B SPRR3	5.24e-06	28	23	3	IPR026075
Domain	Homeobox_CS	ZFHX3 CDX1 CDX2	1.49e-03	186	23	3	IPR017970
Domain	Homeobox	ZFHX3 CDX1 CDX2	2.86e-03	234	23	3	PF00046
Domain	HOMEOBOX_1	ZFHX3 CDX1 CDX2	2.93e-03	236	23	3	PS00027
Domain	HOX	ZFHX3 CDX1 CDX2	2.96e-03	237	23	3	SM00389
Domain	Homeobox_dom	ZFHX3 CDX1 CDX2	3.03e-03	239	23	3	IPR001356
Domain	HOMEOBOX_2	ZFHX3 CDX1 CDX2	3.03e-03	239	23	3	PS50071
Domain	HTH_motif	CDX1 CDX2	3.24e-03	69	23	2	IPR000047
Domain	-	ZFHX3 CDX1 CDX2	4.87e-03	283	23	3	1.10.10.60
Domain	Homeobox_metazoa	CDX1 CDX2	5.44e-03	90	23	2	IPR020479
Domain	Homeodomain-like	ZFHX3 CDX1 CDX2	7.57e-03	332	23	3	IPR009057
Pubmed	The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation.	SPRR1A SPRR1B SPRR3	2.53e-10	3	23	3	7829876
Pubmed	Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype.	SPRR1A SPRR1B SPRR3	5.05e-09	6	23	3	27304082
Pubmed	Mouse Sprr locus: a tandem array of coordinately regulated genes.	SPRR1A SPRR1B SPRR3	1.41e-08	8	23	3	12584609
Pubmed	Long-range comparison of human and mouse Sprr loci to identify conserved noncoding sequences involved in coordinate regulation.	SPRR1A SPRR1B SPRR3	1.41e-08	8	23	3	15574822
Pubmed	Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins.	SPRR1A SPRR1B SPRR3	3.02e-08	10	23	3	8325635
Pubmed	Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues.	SPRR1A SPRR1B SPRR3	5.54e-08	12	23	3	9888996
Pubmed	Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families.	SPRR1A SPRR1B SPRR3	5.54e-08	12	23	3	18643845
Pubmed	Cdx function is required for maintenance of intestinal identity in the adult.	CDX1 CDX2	4.18e-07	2	23	2	22285812
Pubmed	The homeodomain transcription factors Cdx1 and Cdx2 induce E-cadherin adhesion activity by reducing beta- and p120-catenin tyrosine phosphorylation.	CDX1 CDX2	4.18e-07	2	23	2	17463179
Pubmed	Regulation of axial elongation by Cdx.	CDX1 CDX2	4.18e-07	2	23	2	34958748
Pubmed	Single nucleotide polymorphisms of caudal type homeobox 1 and 2 are associated with Barrett's esophagus.	CDX1 CDX2	4.18e-07	2	23	2	23918153
Pubmed	Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors.	CDX1 CDX2	4.18e-07	2	23	2	18187048
Pubmed	Differential gene expression in normal esophagus and Barrett's esophagus.	CDX1 CDX2	4.18e-07	2	23	2	19468668
Pubmed	Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts.	SPRR1A SPRR3	4.18e-07	2	23	2	8018055
Pubmed	The Cdx-1 and Cdx-2 homeobox genes in the intestine.	CDX1 CDX2	4.18e-07	2	23	2	10392709
Pubmed	MiR-463-3p inhibits tibial nerve regeneration via post-transcriptional suppression of SPRR1A.	SPRR1A SPRR1B	4.18e-07	2	23	2	31468997
Pubmed	Expression of the regeneration-associated protein SPRR1A in primary sensory neurons and spinal cord of the adult mouse following peripheral and central injury.	SPRR1A SPRR1B	4.18e-07	2	23	2	19107756
Pubmed	Structure and organization of the genes encoding mouse small proline-rich proteins, mSPRR1A and 1B.	SPRR1A SPRR1B	4.18e-07	2	23	2	9931436
Pubmed	Carbon monoxide modulates alpha-smooth muscle actin and small proline rich-1a expression in fibrosis.	SPRR1A SPRR1B	4.18e-07	2	23	2	19097987
Pubmed	SPRR1B overexpression enhances entry of cells into the G0 phase of the cell cycle.	SPRR1A SPRR1B	4.18e-07	2	23	2	12832281
Pubmed	Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis.	CDX1 CDX2	4.18e-07	2	23	2	9036867
Pubmed	Different effects of the Cdx1 and Cdx2 homeobox genes in a murine model of intestinal inflammation.	CDX1 CDX2	4.18e-07	2	23	2	17595234
Pubmed	Cdx1 and Cdx2 exhibit transcriptional specificity in the intestine.	CDX1 CDX2	4.18e-07	2	23	2	23382958
Pubmed	Cdx regulates gene expression through PRC2-mediated epigenetic mechanisms.	CDX1 CDX2	4.18e-07	2	23	2	34973175
Pubmed	Sequence and expression patterns of mouse SPR1: Correlation of expression with epithelial function.	SPRR1A SPRR1B	4.18e-07	2	23	2	8601731
Pubmed	Essential and redundant functions of caudal family proteins in activating adult intestinal genes.	CDX1 CDX2	4.18e-07	2	23	2	21402776
Pubmed	Cdx binding determines the timing of enhancer activation in postnatal duodenum.	CDX1 CDX2	4.18e-07	2	23	2	15677472
Pubmed	SPRR1 gene induction and barrier formation occur as coordinated moving fronts in terminally differentiating epithelia.	SPRR1A SPRR1B	4.18e-07	2	23	2	10771479
Pubmed	Cdx1 and cdx2 expression during intestinal development.	CDX1 CDX2	4.18e-07	2	23	2	11040183
Pubmed	Follow-Up Study on CDX1 and CDX2 mRNA Expression in Noncancerous Gastric Mucosae After Helicobacter pylori Eradication.	CDX1 CDX2	4.18e-07	2	23	2	26841784
Pubmed	Transgenic Cdx2 induces endogenous Cdx1 in intestinal metaplasia of Cdx2-transgenic mouse stomach.	CDX1 CDX2	4.18e-07	2	23	2	19725873
Pubmed	[Identity and intestinal pathologies: the Cdx2 homeotic gene].	CDX1 CDX2	4.18e-07	2	23	2	23127929
Pubmed	CDX1 and CDX2 expression in intestinal metaplasia, dysplasia and gastric cancer.	CDX1 CDX2	4.18e-07	2	23	2	21532856
Pubmed	CDX1/2 and KLF5 Expression and Epigenetic Modulation of Sonic Hedgehog Signaling in Gastric Adenocarcinoma.	CDX1 CDX2	1.25e-06	3	23	2	30685841
Pubmed	Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth.	SPRR1A SPRR1B	1.25e-06	3	23	2	11850458
Pubmed	Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2.	CDX1 CDX2	1.25e-06	3	23	2	25500896
Pubmed	Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity.	CDX1 CDX2	1.25e-06	3	23	2	15215241
Pubmed	cdx4/lacZ and cdx2/lacZ protein gradients formed by decay during gastrulation in the mouse.	CDX1 CDX2	1.25e-06	3	23	2	16281167
Pubmed	Cdx4 is a Cdx2 target gene.	CDX1 CDX2	1.25e-06	3	23	2	20933081
Pubmed	CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium.	CDX1 CDX2	1.25e-06	3	23	2	19900445
Pubmed	Cdx gene deficiency compromises embryonic hematopoiesis in the mouse.	CDX1 CDX2	1.25e-06	3	23	2	18511567
Pubmed	Cdx1 refines positional identity of the vertebrate hindbrain by directly repressing Mafb expression.	CDX1 CDX2	1.25e-06	3	23	2	21098558
Pubmed	Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2.	CDX1 CDX2	1.25e-06	3	23	2	15774940
Pubmed	The effect of miR-372-5p regulation on CDX1 and CDX2 in the gastric cancer cell line.	CDX1 CDX2	1.25e-06	3	23	2	36848481
Pubmed	Cdx1 and Cdx2 function as tumor suppressors.	CDX1 CDX2	1.25e-06	3	23	2	25320087
Pubmed	Anterior expression of the caudal homologue cCdx-B activates a posterior genetic program in avian embryos.	CDX1 CDX2	1.25e-06	3	23	2	11500978
Pubmed	Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2.	CDX1 CDX2	1.25e-06	3	23	2	21074721
Pubmed	Caudal-related homeobox (Cdx) protein-dependent integration of canonical Wnt signaling on paired-box 3 (Pax3) neural crest enhancer.	CDX1 CDX2	1.25e-06	3	23	2	22457346
Pubmed	Modulation of murine embryonic stem cell-derived CD41+c-kit+ hematopoietic progenitors by ectopic expression of Cdx genes.	CDX1 CDX2	1.25e-06	3	23	2	18252864
Pubmed	Structure of the murine homeobox gene cdx-2. Expression in embryonic and adult intestinal epithelium.	CDX1 CDX2	1.25e-06	3	23	2	7910823
Pubmed	Cdx1 or Cdx2 expression activates E-cadherin-mediated cell-cell adhesion and compaction in human COLO 205 cells.	CDX1 CDX2	1.25e-06	3	23	2	14977637
Pubmed	Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2.	CDX1 CDX2	1.25e-06	3	23	2	19781065
Pubmed	Dysregulation of CDX1, CDX2 and SOX2 in patients with gastric cancer also affects the non-malignant mucosa.	CDX1 CDX2	1.25e-06	3	23	2	23613102
Pubmed	Regulation of the gene encoding the intestinal bile acid transporter ASBT by the caudal-type homeobox proteins CDX1 and CDX2.	CDX1 CDX2	1.25e-06	3	23	2	22016432
Pubmed	Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa--with special emphasis on participation in intestinal metaplasia of the human stomach.	CDX1 CDX2	1.25e-06	3	23	2	11846061
Pubmed	Cardiomyocyte microRNA-150 confers cardiac protection and directly represses proapoptotic small proline-rich protein 1A.	SPRR1A SPRR1B	1.25e-06	3	23	2	34403363
Pubmed	Multiple pathways governing Cdx1 expression during murine development.	CDX1 CDX2	1.25e-06	3	23	2	11784033
Pubmed	Cdx2 Regulates Gene Expression through Recruitment of Brg1-associated Switch-Sucrose Non-fermentable (SWI-SNF) Chromatin Remodeling Activity.	CDX1 CDX2	1.25e-06	3	23	2	28082674
Pubmed	SPRR1A is a key downstream effector of MiR-150 during both maladaptive cardiac remodeling in mice and human cardiac fibroblast activation.	SPRR1A SPRR1B	1.25e-06	3	23	2	37468478
Pubmed	[Expression and clinical significance of caudal type homeobox transcription factor-2 in adult acute lymphocytic leukemia].	CDX1 CDX2	1.25e-06	3	23	2	21518475
Pubmed	Cdx mediates neural tube closure through transcriptional regulation of the planar cell polarity gene Ptk7.	CDX1 CDX2	2.51e-06	4	23	2	21350009
Pubmed	Increased Cdx protein dose effects upon axial patterning in transgenic lines of mice.	CDX1 CDX2	2.51e-06	4	23	2	18579683
Pubmed	Nervous System Regionalization Entails Axial Allocation before Neural Differentiation.	CDX1 CDX2	2.51e-06	4	23	2	30343898
Pubmed	S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes.	SPRR1A SPRR1B	4.18e-06	5	23	2	9115270
Pubmed	Isx participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15,15'-monooxygenase (Bcmo1) expression.	CDX1 CDX2	4.18e-06	5	23	2	18093975
Pubmed	Cdx1 and Cdx2 are functionally equivalent in vertebral patterning.	CDX1 CDX2	4.18e-06	5	23	2	19328777
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	DHX15 ATXN2L CCNK NELFA ZYX VARS1 BRD4	4.97e-06	1103	23	7	34189442
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	KIF20A DHX15 ATXN2L ZYX VARS1 STAU2	5.95e-06	724	23	6	36232890
Pubmed	Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation.	CDX1 CDX2	6.26e-06	6	23	2	11959827
Pubmed	Genomic organization and mapping of the human and mouse neuronal beta2-nicotinic acetylcholine receptor genes.	SPRR1A SPRR1B	6.26e-06	6	23	2	10441742
Pubmed	Developmental regulation of the Hox genes during axial morphogenesis in the mouse.	CDX1 CDX2	8.77e-06	7	23	2	15944185
Pubmed	Functional characterization of the CCL25 promoter in small intestinal epithelial cells suggests a regulatory role for caudal-related homeobox (Cdx) transcription factors.	CDX1 CDX2	8.77e-06	7	23	2	16517733
Pubmed	Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes.	SPRR1A SPRR1B	8.77e-06	7	23	2	10908733
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZYX ZFHX3 CPSF4 CDX1 BRD4 CDX2	1.11e-05	808	23	6	20412781
Pubmed	Role of Cdx factors in early mesodermal fate decisions.	CDX1 CDX2	1.17e-05	8	23	2	30936115
Pubmed	Cdx2 determines the fate of postnatal intestinal endoderm.	CDX1 CDX2	1.17e-05	8	23	2	22190642
Pubmed	Pdx1-related homeodomain transcription factors are distinctly expressed in mouse adult pancreatic islets.	CDX1 CDX2	1.50e-05	9	23	2	15888377
Pubmed	Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function.	SPRR1A SPRR3	1.50e-05	9	23	2	11279051
Pubmed	Cdx regulates Dll1 in multiple lineages.	CDX1 CDX2	1.50e-05	9	23	2	22015720
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	DHX15 CCNK NELFA ZYX BRD4	1.73e-05	506	23	5	30890647
Pubmed	Cdk12 is essential for embryonic development and the maintenance of genomic stability.	CCNK CDX2	1.88e-05	10	23	2	26658019
Pubmed	Loss-of-function mutations in FREM2 disrupt eye morphogenesis.	SPRR1A SPRR1B	2.29e-05	11	23	2	30802441
Pubmed	HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity.	SPRR1A SPRR1B	2.29e-05	11	23	2	32467224
Pubmed	The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.	DHX15 ZFHX3	2.29e-05	11	23	2	26232227
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	CCNK NELFA CPSF4 BRD4	2.72e-05	268	23	4	33640491
Pubmed	Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression.	CDX1 CDX2	2.75e-05	12	23	2	11335109
Pubmed	Cdx2 regulates patterning of the intestinal epithelium.	CDX1 CDX2	2.75e-05	12	23	2	20043902
Pubmed	Insights into the ubiquitin-proteasome system of human embryonic stem cells.	DHX15 CCNK NELFA CPSF4	2.76e-05	269	23	4	29511261
Pubmed	BET proteins are essential for the specification and maintenance of the epiblast lineage in mouse preimplantation embryos.	BRD4 CDX2	3.25e-05	13	23	2	35264162
Pubmed	TFEB regulates murine liver cell fate during development and regeneration.	SPRR1A SPRR1B	3.25e-05	13	23	2	32424153
Pubmed	Effect of retinoic acid signaling on Wnt/beta-catenin and FGF signaling during body axis extension.	CDX1 CDX2	3.79e-05	14	23	2	19539783
Pubmed	Essential roles for Cdx in murine primitive hematopoiesis.	CDX1 CDX2	3.79e-05	14	23	2	28065741
Pubmed	Lymphotoxin-beta regulates periderm differentiation during embryonic skin development.	SPRR1A SPRR1B	3.79e-05	14	23	2	17673451
Pubmed	Three-dimensional molecular architecture of mouse organogenesis.	SPRR1A SPRR1B CDX2	3.92e-05	100	23	3	37524711
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	DHX15 SPRR1B NELFA ZYX	4.11e-05	298	23	4	30737378
Pubmed	Cdx2 is essential for axial elongation in mouse development.	CDX1 CDX2	4.37e-05	15	23	2	15136723
Pubmed	Cdx2 regulation of posterior development through non-Hox targets.	CDX1 CDX2	4.99e-05	16	23	2	19906845
Pubmed	Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos.	CDX1 CDX2	4.99e-05	16	23	2	15057272
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DHX15 CCNK VARS1 CPSF4 BRD4 STAU2	5.73e-05	1082	23	6	38697112
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	CCNK NELFA CPSF4 BRD4	6.78e-05	339	23	4	30415952
Interaction	SRSF7 interactions	KIF20A DHX15 CCNK CPSF4 BRD4 STAU2	6.32e-06	425	23	6	int:SRSF7
Interaction	PRPF40A interactions	KIF20A DHX15 ATXN2L ZFHX3 BRD4 CDX2	8.33e-06	446	23	6	int:PRPF40A
Interaction	SRSF1 interactions	KIF20A DHX15 NELFA CDX1 BRD4 STAU2	3.34e-05	570	23	6	int:SRSF1
Interaction	CEBPA interactions	DHX15 ATXN2L CCNK NELFA ZYX VARS1 CDX1 BRD4	4.41e-05	1245	23	8	int:CEBPA
Interaction	VTN interactions	KIF20A DHX15 ITGA8 BRD4	5.09e-05	183	23	4	int:VTN
Interaction	MECP2 interactions	DHX15 PRPF40B ATXN2L CCNK VARS1 CPSF4 BRD4 STAU2	5.59e-05	1287	23	8	int:MECP2
Interaction	DDX42 interactions	DHX15 ATXN2L CDX1 BRD4	8.37e-05	208	23	4	int:DDX42
Interaction	RBBP6 interactions	KIF20A CPSF4 CDX1 BRD4	9.68e-05	216	23	4	int:RBBP6
Interaction	ACTC1 interactions	KIF20A DHX15 CCNK NELFA ZYX BRD4	9.97e-05	694	23	6	int:ACTC1
Interaction	BRDT interactions	NELFA TMEM214 BRD4	1.05e-04	81	23	3	int:BRDT
Interaction	CABIN1 interactions	SPRR1B CDX1 GRM1	1.12e-04	83	23	3	int:CABIN1
Interaction	FIP1L1 interactions	KIF20A ATXN2L CPSF4 BRD4	1.13e-04	225	23	4	int:FIP1L1
Interaction	PAPOLA interactions	ATXN2L ZYX BRD4	1.53e-04	92	23	3	int:PAPOLA
Interaction	TMPO interactions	KIF20A DHX15 ATXN2L VARS1 TMEM214 BRD4	1.67e-04	762	23	6	int:TMPO
Interaction	SRSF3 interactions	KIF20A DHX15 CPSF4 BRD4 STAU2	2.61e-04	522	23	5	int:SRSF3
Interaction	TBR1 interactions	KIF20A ZFHX3 BRD4	2.80e-04	113	23	3	int:TBR1
Interaction	ADAR interactions	KIF20A DHX15 BRD4 STAU2	2.84e-04	286	23	4	int:ADAR
Interaction	FMR1 interactions	KIF20A ATXN2L CDX1 BRD4 RAPGEF2	2.95e-04	536	23	5	int:FMR1
Interaction	HNRNPUL2 interactions	KIF20A BRD4 CDX2 STAU2	3.04e-04	291	23	4	int:HNRNPUL2
Interaction	LAP3 interactions	ZYX VARS1 RAPGEF2	3.10e-04	117	23	3	int:LAP3
Interaction	HDLBP interactions	DHX15 CCNK ZYX VARS1 CPSF4 STAU2	3.11e-04	855	23	6	int:HDLBP
Interaction	MFAP1 interactions	KIF20A PRPF40B ATXN2L BRD4	3.20e-04	295	23	4	int:MFAP1
Interaction	HDAC2 interactions	KIF20A DHX15 SPRR1B NELFA ZYX BRD4	3.31e-04	865	23	6	int:HDAC2
Interaction	P4HA1 interactions	KIF20A PRPF40B CPSF4 BRD4	3.32e-04	298	23	4	int:P4HA1
Cytoband	1q21-q22	SPRR1A SPRR1B SPRR3	1.93e-07	23	23	3	1q21-q22
Cytoband	Ensembl 112 genes in cytogenetic band chr1q21	SPRR1A SPRR1B SPRR3	1.05e-03	404	23	3	chr1q21
GeneFamily	Small proline rich proteins	SPRR1A SPRR1B SPRR3	7.59e-08	11	15	3	1353
GeneFamily	HOXL subclass homeoboxes	CDX1 CDX2	8.32e-04	52	15	2	518
CoexpressionAtlas	AravindRamakr_EmbryoidBody-LF_top-relative-expression-ranked_500_k-means-cluster#4	SPRR1A SPRR1B SPRR3	3.47e-05	59	23	3	Arv_EB-LF_500_K4
CoexpressionAtlas	BM Top 100 - cervix	SPRR1A SPRR1B SPRR3	4.86e-05	66	23	3	BM Top 100 - cervix
CoexpressionAtlas	BM Top 100 - vagina	SPRR1A SPRR1B SPRR3	7.41e-05	76	23	3	BM Top 100 - vagina
CoexpressionAtlas	BM Top 100 - tongue superior part w_papillae	SPRR1A SPRR1B SPRR3	8.32e-05	79	23	3	BM Top 100 - tongue superior part w_papillae
CoexpressionAtlas	BM Top 100 - esophagus	SPRR1A SPRR1B SPRR3	1.07e-04	86	23	3	BM Top 100 - esophagus
CoexpressionAtlas	Progenitor-Cell-Biology-Consortium_reference_BronchioEpithel_top-relative-expression-ranked_100	SPRR1A SPRR1B SPRR3	1.58e-04	98	23	3	PCBC_ctl_BronchioEpithel_100
CoexpressionAtlas	AravindRamakr_EmbryoidBody-LF_top-relative-expression-ranked_1000_k-means-cluster#5	SPRR1A SPRR1B SPRR3	3.09e-04	123	23	3	Arv_EB-LF_1000_K5
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KIF20A SPRR1A SPRR1B SPRR3	2.96e-06	197	23	4	dcabea5c50c133c9a4e294e447462d0393174ea7
ToppCell	Bronchial_Brush-Epithelial-Ciliated_2\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	SPRR1A SPRR1B SPRR3	4.19e-05	132	23	3	780a391924f776dc6fbe44ddcf4ae0583a1e2157
ToppCell	Bronchial_Brush-Epithelial-Ciliated_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	SPRR1A SPRR1B SPRR3	4.48e-05	135	23	3	366a417f9ef7c0d86e9f262d97bf788f478315ee
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-FB-3\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	ITGA8 PRPF40B VARS1	4.68e-05	137	23	3	25b5370b63644351efddb8749ef174beca0581cd
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_ductal_cel\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRR1A CDX1 CDX2	6.00e-05	149	23	3	7726957b1de638c3bfc659381d15eab626bb179b
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM5-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPRR1A SPRR1B SPRR3	8.27e-05	166	23	3	006ced12f69ef13ddcba5a3891ddc7c18c384863
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM5-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SPRR1A SPRR1B SPRR3	8.27e-05	166	23	3	6bb3410e65c971acc458c472015afcec6de6e310
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM5\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPRR1A SPRR1B SPRR3	8.27e-05	166	23	3	ac28c8cac1e94be0c47fb862c5809c92cdaa11f3
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM5\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SPRR1A SPRR1B SPRR3	8.27e-05	166	23	3	823ec03714884cb860a1260410feac8c536b6d06
ToppCell	facs-GAT-Fat-18m-Epithelial\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRR1A CDX1 CDX2	8.57e-05	168	23	3	d6c8056b7d6b937bb91e6b33beeb1075dce1685c
ToppCell	facs-GAT-Fat-18m-Epithelial-epithelial_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRR1A CDX1 CDX2	8.57e-05	168	23	3	7102c52bf1b2ba67bb3700932181a2e0a6627711
ToppCell	facs-GAT-Fat-18m-Epithelial-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRR1A CDX1 CDX2	8.57e-05	168	23	3	68a2f9fd53b54023241acd1620cf24226f639c1b
ToppCell	NS-moderate-d_0-4-Epithelial-Squamous\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1A SPRR1B SPRR3	8.72e-05	169	23	3	4a5d023ffcf83312d29b1d215eb6b744ef1a0777
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1A SPRR1B SPRR3	8.88e-05	170	23	3	13a225e32132e9717debb0d64d7c28ada974c3e6
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-Goblet\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SPRR1A SPRR1B SPRR3	9.03e-05	171	23	3	fe27bf581c75ef33c2848878e51ed16b275a4c8e
ToppCell	cellseq2-Epithelial-Epithelial_Glandular-Goblet-Goblet\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SPRR1A SPRR1B SPRR3	9.03e-05	171	23	3	25c1979e972c959e1ce4c57804f976f53a247ad7
ToppCell	TCGA-Head_and_Esophagus\|World / Sample_Type by Project: Shred V9	SPRR1A SPRR1B SPRR3	9.19e-05	172	23	3	eb18aa179db1818f408c38e442ecfed8582d7dbc
ToppCell	facs-GAT-Fat-24m-Epithelial\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A CDX1 CDX2	9.35e-05	173	23	3	815ba48a9222ea09ba8005e2d2f7c5addf118ad1
ToppCell	facs-GAT-Fat-24m-Epithelial-nan\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A CDX1 CDX2	9.35e-05	173	23	3	98e464d9e6d6b69421e9e4041b638b6825247f60
ToppCell	facs-GAT-Fat-24m-Epithelial-epithelial_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF20A CDX1 CDX2	9.35e-05	173	23	3	3e6f0a08eddfd61871f7a85acccf6d539af6ebda
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1A SPRR1B SPRR3	9.67e-05	175	23	3	8252ddc2ca95071381f0354aefb70c4714828491
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF20A ZFHX3 RAPGEF2	9.67e-05	175	23	3	3e56695a9db97cb1d3503425c48eb79bbf99213e
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	SPRR1A SPRR1B SPRR3	9.67e-05	175	23	3	0cc215109d9915af47e4d0a120ce2e46910715fa
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1A SPRR1B SPRR3	9.67e-05	175	23	3	8ccf60fc469059d7aaf4e6ce54159db2962e0060
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF20A CDX1 AFF2	1.00e-04	177	23	3	2b63f0529ef73e0eede9b7ef1f08b0a0426a9c82
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-5\|TCGA-Lung / Sample_Type by Project: Shred V9	SPRR1A SPRR1B SPRR3	1.00e-04	177	23	3	a0c7d08469c513cecf87777c19876884f1511570
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1A SPRR1B SPRR3	1.03e-04	179	23	3	2b5f8e109a67c7fc3ec2b83e8f1854160c99283a
ToppCell	NS\|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1A SPRR1B SPRR3	1.05e-04	180	23	3	8472dcce7bc0b7ce428ec17ddf0018f3258f78d2
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-suprabasal_interpapillary\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRR1A SPRR1B SPRR3	1.05e-04	180	23	3	18bf8561ad3aa9787d2a8ef942a96f641734c608
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Colonocyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPRR1B SPRR3 CDX2	1.07e-04	181	23	3	bec917f6f56ae252639a5a76024be5df5c70a6d5
ToppCell	PSB-critical-LOC-Epithelial-Squamous\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1A SPRR1B SPRR3	1.10e-04	183	23	3	2cf798a2371c61322484ea16fdfae0acfa94f102
ToppCell	droplet-Tongue-nan-24m-Epithelial-keratinocyte\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRR1A SPRR1B SPRR3	1.10e-04	183	23	3	9e6c96ada930e8559246a270dfc69fb3cbb3bdf3
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ITGA8 ZFHX3 AFF2	1.12e-04	184	23	3	327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1A SPRR1B SPRR3	1.14e-04	185	23	3	f3fbc3096f85397a959cee17c3c4fcf2d511f3d5
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-epithelial_progenitor_cell-TA\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KIF20A CDX1 CDX2	1.20e-04	188	23	3	b3cae49f0665ace0016a6441cbf9ae40755b0ea3
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ITGA8 CDX1 AFF2	1.20e-04	188	23	3	ccddc08121caff958a2b6f9e278a018858af6b4d
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma\|TCGA-Lung / Sample_Type by Project: Shred V9	SPRR1A SPRR1B SPRR3	1.21e-04	189	23	3	aa4f7d7a5196e5ae481ebc2549de8e3f0ef6e6be
ToppCell	BL-critical-LOC-Epithelial-Squamous\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1A SPRR1B SPRR3	1.25e-04	191	23	3	3f9b8c4fb72ae6f3167b187e6715c4dcb3159f98
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1A SPRR1B SPRR3	1.25e-04	191	23	3	fbd8d337b4444fba8527a614e4a8bfb516ce0f66
ToppCell	NS-moderate-d_16-33-Epithelial-Squamous\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1A SPRR1B SPRR3	1.27e-04	192	23	3	103496f428f59683ac3ae6147682c07c30663724
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ITGA8 ZFHX3 GRM1	1.29e-04	193	23	3	323d1f3f4fbeb93ba857fc135d8aa0b897f98ac5
ToppCell	CTRL-Epithelial-Epithelial_cell\|CTRL / Disease state, Lineage and Cell class	SPRR1A SPRR1B SPRR3	1.31e-04	194	23	3	2bc4deaf2a01a39809fc323962fce4286835209c
ToppCell	NS-critical-d_07-13-Epithelial-Squamous\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1A SPRR1B SPRR3	1.31e-04	194	23	3	53a34843d529ef395deb27086f71f7049a087bab
ToppCell	NS-critical-d_0-4-Epithelial-Squamous\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1A SPRR1B SPRR3	1.31e-04	194	23	3	614d0c25b56957c70f397abb169fd2a860eb1c06
ToppCell	CTRL-Epithelial\|CTRL / Disease state, Lineage and Cell class	SPRR1A SPRR1B SPRR3	1.31e-04	194	23	3	49dcb31427f370692308f939e23992925708abb7
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ITGA8 ZFHX3 AFF2	1.31e-04	194	23	3	6a4e7f1bf67bad94cd8c472e7c66798b0c25ba01
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-squamous_epithelial_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SPRR1A SPRR1B SPRR3	1.33e-04	195	23	3	82d87fdb39ec15be9057e2d2ba5c1afb5f97aafe
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-Plasma_cell-B_c06-MKI67\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	KIF20A VARS1 TMEM214	1.33e-04	195	23	3	533818e89d809f01fbb5c4b57932b76aa5c8f30e
ToppCell	NS-moderate-d_07-13\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1A SPRR1B SPRR3	1.33e-04	195	23	3	088209505a68519ec89f50f0576096da6966bf17
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-squamous_epithelial_cell-Epi-Squamous\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SPRR1A SPRR1B SPRR3	1.33e-04	195	23	3	dd8117dbd22892288f74a7314ab0b5080106936c
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1A SPRR1B SPRR3	1.33e-04	195	23	3	24d226f89dd337c22728688e4b40ca082a0e1fe1
ToppCell	NS-critical-d_16-33-Epithelial-Squamous\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1A SPRR1B SPRR3	1.35e-04	196	23	3	97e16d9833e4083d719ca7058d5fc9b11edb37e3
ToppCell	NS-critical-LOC-Epithelial-Squamous\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1A SPRR1B SPRR3	1.35e-04	196	23	3	453c809494ceffa2a28af283c4b5a4924fcf160f
ToppCell	BAL-Severe-Epithelial-Epithelial-transitional_Epi-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPRR1A SPRR1B SPRR3	1.35e-04	196	23	3	1efacc37bbfbd05b5d4db3dd10f6d9a238d23e31
ToppCell	BAL-Severe-Epithelial-Epithelial-transitional_Epi\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPRR1A SPRR1B SPRR3	1.35e-04	196	23	3	3e99a367b7d817e1f1221450fcec20ad7a7c7a2a
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_monocytic\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SPRR1A SPRR1B SPRR3	1.35e-04	196	23	3	03de28e1c963e99623e8b0e33bf2e8ef67dc3baa
ToppCell	COVID-19-lung-Pericytes/_Smooth_Muscle\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ITGA8 ZFHX3 AFF2	1.35e-04	196	23	3	754a3613340932563cd8424d775e18b93c3a1aaa
ToppCell	BAL-Severe-Epithelial-Epithelial-transitional_Epi-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SPRR1A SPRR1B SPRR3	1.37e-04	197	23	3	08b371309cd790b171ed76cabc7d910e71cd2835
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1A SPRR1B SPRR3	1.37e-04	197	23	3	fb272c9c60ee3d980e528044dc567b4925a23da6
ToppCell	critical-Epithelial-Squamous\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPRR1A SPRR1B SPRR3	1.37e-04	197	23	3	cfbdaada7169afb68455724ae87032ff311b2d89
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SPRR1A SPRR1B SPRR3	1.37e-04	197	23	3	ac9c0c25cfeaabd53d332982c73fc6c47b0c6478
ToppCell	NS-control-d_0-4-Epithelial-Squamous\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1A SPRR1B SPRR3	1.37e-04	197	23	3	ab965a0ba87efd3329d24a1ec123985f46fc17c0
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1A SPRR1B SPRR3	1.37e-04	197	23	3	61c0d78b29dc4ad8a84172cbfcdab03f31351d0e
ToppCell	distal-1-Epithelial-Basal\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SPRR1A SPRR1B SPRR3	1.37e-04	197	23	3	25a2ccc98b973611de0d920b1b455d0b40f0d37f
ToppCell	moderate-Epithelial-Squamous\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPRR1A SPRR1B SPRR3	1.37e-04	197	23	3	ab3c90a5b643b45d0b83939c6304b11f567c5d78
ToppCell	moderate-Epithelial-Squamous\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPRR1A SPRR1B SPRR3	1.37e-04	197	23	3	2e13881f917d4f62a5b3e968e41c57e43300d988
ToppCell	BAL-Severe-Epithelial-Epithelial-transitional_Epi\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	SPRR1A SPRR1B SPRR3	1.37e-04	197	23	3	9f49feee38647bbf964974aac96fa75602186b5c
ToppCell	critical-Epithelial-Squamous\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPRR1A SPRR1B SPRR3	1.37e-04	197	23	3	eccc80d6ab79c46b10108de1cff3abeacfc105cd
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_monocytic-leukocyte\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SPRR1A SPRR1B SPRR3	1.37e-04	197	23	3	e621d4f9d4ba5e3ef17d2b477e5e14ea0251147e
ToppCell	distal-Epithelial-Basal-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SPRR1A SPRR1B SPRR3	1.37e-04	197	23	3	75b4292ce2ad7f9c8b6a4781e1cb71f5b18b74e3
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Epithelial\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SPRR1A SPRR1B SPRR3	1.37e-04	197	23	3	b57d2e3413ef6dd1da56c45087926f2f3eab876c
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPRR1A SPRR1B SPRR3	1.39e-04	198	23	3	e06d41a7254a09e037ec404be2d8c352d5cbd7f4
ToppCell	control-Epithelial-Squamous\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPRR1A SPRR1B SPRR3	1.39e-04	198	23	3	6ba669ac1ed275ae309054941b1457e315766faa
ToppCell	NS-moderate-d_07-13-Epithelial-Squamous\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPRR1A SPRR1B SPRR3	1.39e-04	198	23	3	b7495369baba203490c067a58fc8456a778a12e4
ToppCell	distal-Epithelial-Differentiating_Basal-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SPRR1A SPRR1B SPRR3	1.41e-04	199	23	3	a1b87c74fe3106ff8bf1c6ff4048d0c3d3fee7ba
ToppCell	(04)_Interm._basal>secr.-(1)_GFP\|(04)_Interm._basal>secr. / shred by cell type by condition	SPRR1B ZYX SPRR3	1.41e-04	199	23	3	7a0d40d4679dc373829d67693851428f41c8b0d6
ToppCell	control-Epithelial-Squamous\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SPRR1A SPRR1B SPRR3	1.41e-04	199	23	3	e13dca7a055cdca53dd6c26c04b2a46d58b419b6
ToppCell	(00)_Basal-(1)_GFP\|(00)_Basal / shred by cell type by condition	SPRR1B ZYX SPRR3	1.41e-04	199	23	3	105b15157f35df3fdf857e306f11e4e8200e05d4
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)\|Smart-seq2 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SPRR1A SPRR1B SPRR3	1.41e-04	199	23	3	8be7cb9d8b4f9707efb69c681c40e683fcd810e5
ToppCell	distal-Epithelial-Differentiating_Basal\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SPRR1A SPRR1B SPRR3	1.41e-04	199	23	3	286d52f25120293620bdbfd62b832f08e118adf6
ToppCell	(00)_Basal\|World / shred by cell type by condition	SPRR1A SPRR1B ZYX	1.41e-04	199	23	3	bc0201e77a1690e3e0a6ecd05cd105e1f5c0ba7b
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-epithelial_progenitor_cell-TA\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KIF20A CDX1 CDX2	1.41e-04	199	23	3	7816ad127b16208b1046da53f4a295b4a747b4cc
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Pericyte\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ITGA8 ZFHX3 AFF2	1.44e-04	200	23	3	b22cae282591d8dead9869c2adbb9632615f50f7
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_only / Treatment groups by lineage, cell group, cell type	ITGA8 ZFHX3 AFF2	1.44e-04	200	23	3	69edc375d85689300d1dbc1217fedc40063ecdcb
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SPRR1A GRM1	1.22e-03	101	23	2	cf52c93f523c5f25bd45519a1444ce7bd1d8b577
ToppCell	Thalamus\|World / BrainAtlas - Mouse McCarroll V32	ZFHX3 CDX1	1.61e-03	116	23	2	5ddfb2dd5459ff6d7ae38163a38eae64fda283b7
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ITGA8 ZFHX3	1.66e-03	118	23	2	e5202fadb3f9d91e56337ddad1666196ec748d87
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Crh_4930553C11Rik_\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	SPRR1B GRM1	1.98e-03	129	23	2	6bc85761dea1f97c19bb379a99e4daf85d53201e
ToppCell	LPS_only-Hematopoietic_Erythro-Megakary-Erythro-Mega-Platelets\|LPS_only / Treatment groups by lineage, cell group, cell type	KIF20A VARS1	2.27e-03	138	23	2	6ddd50e44a3914596b4cd61ae64a987119fe7979
ToppCell	facs-Lung-EPCAM-3m-Hematologic-leukocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX1 CDX2	2.33e-03	140	23	2	731b46e4b815a45af1d0ce7ab4d0d0324ac8798f
ToppCell	facs-Lung-EPCAM-3m-Hematologic-Proliferating_Immune\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX1 CDX2	2.33e-03	140	23	2	b30fc389583406ee6cb55112d0f7250d1b74c88a
ToppCell	facs-Lung-EPCAM-3m-Hematologic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX1 CDX2	2.33e-03	140	23	2	35ecd887bb7827603ef673912ba820208a6368d2
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDX1 CDX2	2.56e-03	147	23	2	a5ed71afe5fcb4f541080f5552252695c7d4d090
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Esophageal_Carcinoma-Adenocarcinoma\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	CDX1 CDX2	2.63e-03	149	23	2	92a8931a51db619fb5f0638d319c02e7838f6559
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-24m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPRR1A CDX1	2.63e-03	149	23	2	d259e9137109eeb2662022f0915ca463f5bebdfe
ToppCell	PND01-03-samps-Myeloid-Macrophage-macrophage-B\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	KIF20A MAK	2.74e-03	152	23	2	5ce8920aedd39a4daf7082153b5e213707c14227
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA8 ZFHX3	2.74e-03	152	23	2	0cb5f4dfae04e3f4eba502bbf229007d5fa3884d
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA8 ZFHX3	2.74e-03	152	23	2	ba89ffb5a8bb33c188f854f54b39123b6d73496a
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KIF20A SPRR3	2.77e-03	153	23	2	499670e716fc85ce76630fc813cec86f8419f2a1
ToppCell	Bronchial_Biopsy-Epithelial-Goblet_2\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	SPRR1B SPRR3	2.77e-03	153	23	2	b25629953ff79aff645845376132b12023067b01
Computational	Neighborhood of SPRR1B	SPRR1A SPRR1B SPRR3	9.26e-06	24	19	3	GNF2_SPRR1B
Computational	Neighborhood of CCNF	NELFA CPSF4 AFF2	3.28e-04	78	19	3	MORF_CCNF
Computational	Neighborhood of EIF4E	NELFA VARS1 CPSF4	4.22e-04	85	19	3	MORF_EIF4E
Drug	PNU-0230031 [267429-39-0]; Down 200; 10uM; PC3; HT_HG-U133A	KIF20A ZYX ZFHX3 BRD4	3.83e-05	192	23	4	4288_DN
Drug	Oxethazaine [126-27-2]; Down 200; 8.6uM; PC3; HT_HG-U133A	SPRR1A ZYX ZFHX3 BRD4	3.99e-05	194	23	4	4246_DN
Drug	Iodipamide [606-17-7]; Up 200; 3.6uM; MCF7; HT_HG-U133A	ATXN2L SPRR1B ZYX ZFHX3	4.15e-05	196	23	4	5510_UP
Drug	Scopolamine hydrochloride [55-16-3]; Up 200; 11.8uM; MCF7; HT_HG-U133A	ITGA8 SPRR1B AFF2 GRM1	4.23e-05	197	23	4	3357_UP
Drug	Alprostadil [745-65-3]; Up 200; 11.2uM; MCF7; HT_HG-U133A	ATXN2L SPRR1A CPSF4 AFF2	4.23e-05	197	23	4	7358_UP
Drug	(+,-)-Octopamine hydrochloride [770-05-8]; Down 200; 21uM; HL60; HT_HG-U133A	ATXN2L SPRR1A ZFHX3 GRM1	4.32e-05	198	23	4	3112_DN
Drug	PNU-0230031 [267429-39-0]; Down 200; 1uM; MCF7; HT_HG-U133A	ATXN2L RAPGEF2 AFF2 GRM1	4.32e-05	198	23	4	4757_DN
Drug	Dantrolene sodium salt [14663-23-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	ITGA8 ATXN2L CCNK AFF2	4.40e-05	199	23	4	3978_DN
Drug	Tolfenamic acid [13710-19-5]; Up 200; 15.2uM; MCF7; HT_HG-U133A	ATXN2L SPRR1B MAK GRM1	4.49e-05	200	23	4	5454_UP
Drug	flufenamic acid	VARS1 BRD4 GRM1	1.72e-04	108	23	3	CID000003371
Drug	lomustine; Up 200; 100uM; MCF7; HT_HG-U133A	ATXN2L ZYX CPSF4	8.29e-04	185	23	3	7045_UP
Drug	Monobenzone [103-16-2]; Down 200; 20uM; HL60; HT_HG-U133A	KIF20A ATXN2L GRM1	9.23e-04	192	23	3	3054_DN
Drug	Resveratrol [501-36-0]; Down 200; 17.6uM; MCF7; HT_HG-U133A	KIF20A ZYX BRD4	9.23e-04	192	23	3	2865_DN
Drug	Nifuroxazide [965-52-6]; Up 200; 14.6uM; MCF7; HT_HG-U133A	ATXN2L RAPGEF2 GRM1	9.37e-04	193	23	3	4835_UP
Drug	Trifluridine [70-00-8]; Up 200; 13.6uM; MCF7; HT_HG-U133A	ATXN2L SPRR1A RAPGEF2	9.37e-04	193	23	3	7176_UP
Drug	(-) -Levobunolol hydrochloride [27912-14-7]; Up 200; 12.2uM; HL60; HT_HG-U133A	ITGA8 ATXN2L AFF2	9.37e-04	193	23	3	3015_UP
Drug	Amprolium hydrochloride [137-88-2]; Down 200; 12.6uM; PC3; HT_HG-U133A	SPRR1A ZYX GRM1	9.37e-04	193	23	3	4241_DN
Drug	Isoquinoline, 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro, hydrochloride; Down 200; 16.4uM; PC3; HT_HG-U133A	ATXN2L SPRR1A ZYX	9.37e-04	193	23	3	4226_DN
Drug	Amoxapine [14028-44-5]; Up 200; 12.8uM; MCF7; HT_HG-U133A	MAK RAPGEF2 AFF2	9.37e-04	193	23	3	4996_UP
Drug	0317956-0000 [391210-11-0]; Down 200; 10uM; PC3; HT_HG-U133A	ZYX ZFHX3 BRD4	9.51e-04	194	23	3	4331_DN
Drug	Indoprofen [31842-01-0]; Down 200; 14.2uM; PC3; HT_HG-U133A	SPRR1A ZYX GRM1	9.51e-04	194	23	3	4249_DN
Drug	Cephalosporanic acid, 7-amino [957-68-6]; Down 200; 14.6uM; PC3; HT_HG-U133A	ZYX ZFHX3 GRM1	9.51e-04	194	23	3	4242_DN
Drug	Trichlormethiazide [133-67-5]; Down 200; 10.6uM; PC3; HT_HG-U133A	ZYX ZFHX3 GRM1	9.66e-04	195	23	3	4198_DN
Drug	diclofenac sodium; Down 200; 10uM; MCF7; HG-U133A	ATXN2L CCNK ZYX	9.66e-04	195	23	3	333_DN
Drug	(R)-Propranolol hydrochloride [13071-11-9]; Up 200; 13.6uM; MCF7; HT_HG-U133A	ITGA8 SPRR1A GRM1	9.66e-04	195	23	3	3553_UP
Drug	Tetramisole hydrochloride [16595-80-5]; Down 200; 16.6uM; MCF7; HT_HG-U133A	ATXN2L SPRR1A RAPGEF2	9.66e-04	195	23	3	4412_DN
Drug	Talampicillin hydrochloride [39878-70-1]; Up 200; 7.8uM; PC3; HT_HG-U133A	NELFA MAK GRM1	9.66e-04	195	23	3	7254_UP
Drug	Amphotericin B [1397-89-3]; Up 200; 4.4uM; PC3; HT_HG-U133A	ATXN2L CCNK AFF2	9.66e-04	195	23	3	6303_UP
Drug	Palmatine chloride [3486-67-7]; Up 200; 10.4uM; MCF7; HT_HG-U133A	SPRR1B CCNK ZYX	9.66e-04	195	23	3	2795_UP
Drug	estradiol, USP; Up 200; 0.1uM; HL60; HT_HG-U133A	ITGA8 ATXN2L MAK	9.66e-04	195	23	3	2668_UP
Drug	Riboflavine [83-88-5]; Up 200; 10.6uM; MCF7; HT_HG-U133A	CCNK SPRR3 GRM1	9.66e-04	195	23	3	6822_UP
Drug	Famprofazone [22881-35-2]; Up 200; 10.6uM; PC3; HT_HG-U133A	SPRR1B ZFHX3 CDX1	9.66e-04	195	23	3	4309_UP
Drug	haloperidol; Down 200; 10uM; MCF7; HT_HG-U133A	ATXN2L BRD4 RAPGEF2	9.66e-04	195	23	3	5241_DN
Drug	Cyclopenthiazide [742-20-1]; Up 200; 10.6uM; MCF7; HT_HG-U133A	ATXN2L ZYX GRM1	9.66e-04	195	23	3	4813_UP
Drug	arachidonyl trifluoromethyl ketone; Up 200; 10uM; MCF7; HG-U133A	ATXN2L ZFHX3 RAPGEF2	9.66e-04	195	23	3	327_UP
Drug	Capsaicin [404-86-4]; Up 200; 13uM; HL60; HT_HG-U133A	SPRR1B AFF2 GRM1	9.66e-04	195	23	3	3034_UP
Drug	rofecoxib; Up 200; 10uM; MCF7; HG-U133A	ATXN2L SPRR1A RAPGEF2	9.66e-04	195	23	3	166_UP
Drug	Cisapride [81098-60-4]; Up 200; 8.6uM; MCF7; HT_HG-U133A	ATXN2L CCNK GRM1	9.80e-04	196	23	3	3305_UP
Drug	Napelline [5008-52-6]; Up 200; 11.2uM; MCF7; HT_HG-U133A	SPRR1B BRD4 GRM1	9.80e-04	196	23	3	6824_UP
Drug	Corynanthine hydrochloride [66634-44-4]; Down 200; 10.2uM; PC3; HT_HG-U133A	SPRR1A ZYX ZFHX3	9.80e-04	196	23	3	4227_DN
Drug	Dehydrocholic acid [81-23-2]; Down 200; 9.6uM; HL60; HG-U133A	SPRR1A TMEM214 RAPGEF2	9.80e-04	196	23	3	2023_DN
Drug	(-)-Cinchonidine [485-71-2]; Up 200; 13.6uM; PC3; HT_HG-U133A	SPRR1A SPRR1B ZFHX3	9.80e-04	196	23	3	5833_UP
Drug	Nomegestrol acetate [58652-20-3]; Up 200; 10.8uM; MCF7; HT_HG-U133A	ATXN2L MAK GRM1	9.80e-04	196	23	3	5461_UP
Drug	CP-690334-01 [459212-38-5]; Up 200; 1uM; PC3; HT_HG-U133A	MAK AFF2 GRM1	9.80e-04	196	23	3	3826_UP
Drug	Midodrine hydrochloride [3092-17-9]; Up 200; 13.8uM; MCF7; HT_HG-U133A	ITGA8 ATXN2L CCNK	9.80e-04	196	23	3	2250_UP
Drug	Rapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA	ATXN2L SPRR1A GRM1	9.80e-04	196	23	3	987_UP
Drug	Meropenem [96036-03-2]; Up 200; 10.4uM; MCF7; HT_HG-U133A	SPRR1B AFF2 GRM1	9.80e-04	196	23	3	3564_UP
Drug	Scoulerine [6451-73-6]; Up 200; 12.2uM; MCF7; HT_HG-U133A	ATXN2L ZYX ZFHX3	9.80e-04	196	23	3	5536_UP
Drug	Diphemanil methylsulfate [62-97-5]; Down 200; 10.2uM; MCF7; HT_HG-U133A	ATXN2L SPRR1A GRM1	9.80e-04	196	23	3	4416_DN
Drug	Tocainide hydrochloride; Down 200; 17.4uM; PC3; HT_HG-U133A	MAK AFF2 GRM1	9.80e-04	196	23	3	4256_DN
Drug	Indapamide [26807-65-8]; Up 200; 10.6uM; MCF7; HT_HG-U133A	ATXN2L SPRR1B MAK	9.80e-04	196	23	3	2322_UP
Drug	Sulfadoxine [2447-57-6]; Down 200; 12.8uM; MCF7; HT_HG-U133A	ATXN2L CCNK ZYX	9.80e-04	196	23	3	3547_DN
Drug	Calciferol [50-14-6]; Up 200; 10uM; HL60; HT_HG-U133A	ATXN2L ZFHX3 BRD4	9.80e-04	196	23	3	2442_UP
Drug	Procainamide hydrochloride [614-39-1]; Up 200; 14.8uM; PC3; HT_HG-U133A	SPRR1A RAPGEF2 GRM1	9.80e-04	196	23	3	4602_UP
Drug	Seneciphylline [480-81-9]; Down 200; 12uM; PC3; HT_HG-U133A	SPRR1A ZYX ZFHX3	9.80e-04	196	23	3	4238_DN
Drug	PHA-00745360 [351320-33-7]; Down 200; 10uM; MCF7; HT_HG-U133A	SPRR1A SPRR1B GRM1	9.80e-04	196	23	3	4381_DN
Drug	Methoxy-8-psoralen [298-81-7]; Down 200; 18.6uM; MCF7; HT_HG-U133A	KIF20A ZYX RAPGEF2	9.80e-04	196	23	3	5007_DN
Drug	Rifampicin [13292-46-1]; Up 200; 4.8uM; MCF7; HT_HG-U133A	ITGA8 CCNK MAK	9.80e-04	196	23	3	2847_UP
Drug	Beta-sistosterol [83-46-5]; Up 200; 9.6uM; MCF7; HT_HG-U133A	ATXN2L MAK GRM1	9.80e-04	196	23	3	4154_UP
Drug	Clofilium tosylate [92953-10-1]; Down 200; 7.8uM; MCF7; HT_HG-U133A	CCNK ZYX GRM1	9.80e-04	196	23	3	3187_DN
Drug	Gabazine [105538-73-6]; Down 200; 10.8uM; PC3; HT_HG-U133A	SPRR1A ZYX GRM1	9.80e-04	196	23	3	4236_DN
Drug	Sertaconazole nitrate [99592-39-9]; Up 200; 8uM; PC3; HT_HG-U133A	SPRR1A CCNK GRM1	9.94e-04	197	23	3	4475_UP
Drug	N6-methyladenosine [1867-73-8]; Down 200; 14.2uM; PC3; HT_HG-U133A	SPRR1A ZFHX3 GRM1	9.94e-04	197	23	3	6732_DN
Drug	N-Acetyl-L-leucine [1188-21-2]; Up 200; 23uM; PC3; HT_HG-U133A	SPRR1A AFF2 GRM1	9.94e-04	197	23	3	4622_UP
Drug	Ampyrone [83-07-8]; Up 200; 19.6uM; PC3; HT_HG-U133A	ITGA8 ATXN2L SPRR1A	9.94e-04	197	23	3	4507_UP
Drug	Rilmenidine hemifumarate [54187-04-1]; Down 200; 8.4uM; HL60; HT_HG-U133A	ATXN2L SPRR1A ZFHX3	9.94e-04	197	23	3	3133_DN
Drug	CP-863187 [668981-07-5]; Down 200; 10uM; PC3; HT_HG-U133A	DHX15 ATXN2L STAU2	9.94e-04	197	23	3	7512_DN
Drug	Amethopterin (R,S) [59-05-2]; Up 200; 8.8uM; MCF7; HT_HG-U133A	SPRR1A AFF2 GRM1	9.94e-04	197	23	3	3214_UP
Drug	Diloxanide furoate [3736-81-0]; Up 200; 12.2uM; MCF7; HT_HG-U133A	ITGA8 SPRR1A AFF2	9.94e-04	197	23	3	3399_UP
Drug	5666823; Up 200; 100uM; MCF7; HG-U133A	STAU2 RAPGEF2 AFF2	9.94e-04	197	23	3	609_UP
Drug	Ethisterone [434-03-7]; Down 200; 12.8uM; MCF7; HT_HG-U133A	RAPGEF2 AFF2 GRM1	9.94e-04	197	23	3	2326_DN
Drug	Phenelzine sulfate [156-51-4]; Up 200; 17uM; HL60; HT_HG-U133A	SPRR1A SPRR1B AFF2	9.94e-04	197	23	3	2357_UP
Drug	Rapamycin; Down 200; 0.1uM; HL60; HT_HG-U133A	ATXN2L BRD4 MAK	9.94e-04	197	23	3	2702_DN
Drug	Esculin Hydrate [531-75-9]; Up 200; 11.8uM; MCF7; HT_HG-U133A	SPRR1A SPRR1B SPRR3	9.94e-04	197	23	3	3390_UP
Drug	N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Up 200; 25.2uM; MCF7; HT_HG-U133A	ATXN2L CCNK AFF2	9.94e-04	197	23	3	3836_UP
Drug	Atracurium besylate [64228-81-5]; Up 200; 3.2uM; MCF7; HT_HG-U133A	ATXN2L RAPGEF2 GRM1	9.94e-04	197	23	3	1702_UP
Drug	Pinacidil [85371-64-8]; Up 200; 16.4uM; MCF7; HT_HG-U133A	ITGA8 SPRR1B BRD4	9.94e-04	197	23	3	5456_UP
Drug	PNU-0230031 [267429-39-0]; Down 200; 10uM; MCF7; HT_HG-U133A	ATXN2L BRD4 GRM1	9.94e-04	197	23	3	4754_DN
Drug	Iopamidol [60166-93-0]; Down 200; 5.2uM; MCF7; HT_HG-U133A	ATXN2L ZYX ZFHX3	9.94e-04	197	23	3	3473_DN
Drug	Eucatropine hydrochloride [536-93-6]; Down 200; 12.2uM; MCF7; HT_HG-U133A	ITGA8 SPRR1A CCNK	9.94e-04	197	23	3	3935_DN
Drug	Stachydrine hydrochloride; Up 200; 22.2uM; MCF7; HT_HG-U133A	SPRR1A CCNK GRM1	9.94e-04	197	23	3	6805_UP
Drug	Talampicillin hydrochloride [39878-70-1]; Up 200; 7.8uM; MCF7; HT_HG-U133A	ATXN2L CDX2 AFF2	9.94e-04	197	23	3	7014_UP
Drug	Hydroxytacrine maleate (R,S) [118909-22-1]; Up 200; 12.2uM; PC3; HT_HG-U133A	ATXN2L SPRR1A CDX2	1.01e-03	198	23	3	6651_UP
Drug	nordihydroguaiaretic acid; Down 200; 1uM; MCF7; HT_HG-U133A	ATXN2L SPRR1A BRD4	1.01e-03	198	23	3	5583_DN
Drug	Iodixanol [92339-11-2]; Down 200; 2.6uM; HL60; HT_HG-U133A	ATXN2L ZFHX3 BRD4	1.01e-03	198	23	3	3023_DN
Drug	Cyclacillin [3485-14-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A	ATXN2L SPRR1B CCNK	1.01e-03	198	23	3	4358_UP
Drug	Scopolamin-N-oxide hydrobromide [6106-81-6]; Down 200; 10uM; HL60; HG-U133A	NELFA STAU2 RAPGEF2	1.01e-03	198	23	3	1415_DN
Drug	Flunixin meglumine [42461-84-7]; Down 200; 8.2uM; MCF7; HT_HG-U133A	RAPGEF2 AFF2 GRM1	1.01e-03	198	23	3	4735_DN
Drug	Dropropizine (R,S) [17692-31-8]; Up 200; 17uM; HL60; HT_HG-U133A	SPRR1B CCNK CDX1	1.01e-03	198	23	3	2398_UP
Drug	Caffeic acid [3331-39-5]; Down 200; 22.2uM; HL60; HT_HG-U133A	ATXN2L RAPGEF2 GRM1	1.01e-03	198	23	3	3053_DN
Drug	Minaprine dihydrochloride [25953-17-7]; Up 200; 10.8uM; PC3; HT_HG-U133A	ATXN2L CCNK AFF2	1.01e-03	198	23	3	4230_UP
Drug	Cephalothin sodium salt [58-71-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A	SPRR1B AFF2 GRM1	1.01e-03	198	23	3	6819_UP
Drug	Chloroquine diphosphate [50-63-5]; Up 200; 7.8uM; MCF7; HT_HG-U133A	ITGA8 ZYX ZFHX3	1.01e-03	198	23	3	7012_UP
Drug	Nitrendipine [39562-70-4]; Down 200; 11uM; MCF7; HT_HG-U133A	ATXN2L SPRR1A ZFHX3	1.01e-03	198	23	3	5405_DN
Drug	Nabumetone [42924-53-8]; Up 200; 17.6uM; MCF7; HT_HG-U133A	ATXN2L SPRR1B MAK	1.01e-03	198	23	3	5428_UP
Drug	Tiratricol, 3,3',5-triiodothyroacetic acid [51-24-1]; Up 200; 6.4uM; MCF7; HT_HG-U133A	ITGA8 ATXN2L GRM1	1.01e-03	198	23	3	7011_UP
Drug	Piperidolate hydrochloride [129-77-1]; Down 200; 11.2uM; MCF7; HT_HG-U133A	ATXN2L CCNK BRD4	1.01e-03	198	23	3	3551_DN
Drug	Proparacaine hydrochloride [5875-06-9]; Up 200; 12uM; PC3; HT_HG-U133A	ITGA8 SPRR1B AFF2	1.01e-03	198	23	3	6332_UP
Drug	Dextromethorphan hydrobromide monohydrate [6700-34-1]; Up 200; 10.8uM; MCF7; HT_HG-U133A	ITGA8 ZFHX3 RAPGEF2	1.01e-03	198	23	3	2636_UP
Disease	caudate nucleus volume	ATXN2L ZFHX3	2.49e-04	30	23	2	EFO_0004830
Disease	atopic eczema, psoriasis	SPRR1B SPRR3	3.60e-04	36	23	2	EFO_0000274, EFO_0000676
Disease	facial morphology measurement	DHX15 ITGA8 ZFHX3	5.48e-03	466	23	3	EFO_0007841
Disease	Colonic Neoplasms	BRD4 CDX2	6.21e-03	152	23	2	C0009375
Disease	Malignant tumor of colon	BRD4 CDX2	6.78e-03	159	23	2	C0007102
Disease	trauma exposure measurement	ZFHX3 BRD4	7.89e-03	172	23	2	EFO_0010703

Protein segments in the cluster

Peptide	Gene	Start	Entry
KVNKKKQQQQQPPQP	CDX1	211	P47902
KQQQQQPPQPPMAHD	CDX1	216	P47902
KKKLQQQQQQQPPQP	CDX2	246	Q99626
HQSPPQQNVQPKKQE	BRD4	1081	O60885
GIPKNSVPQNPNNKN	AFF2	96	P51816
AQQQQPAQQPKKPSP	CCNK	311	O75909
QQQRIFEPPPPKKQN	DHX15	396	O43143
MLKPQPLQQPSQPQQ	ATXN2L	1	Q8WWM7
APQTQAPAQQQPKKN	NELFA	416	Q9H3P2
QCQPNPNINPQDIKP	ITGA8	866	P53708
QQPPKQQSQEKPPQT	MAK	356	P20794
LPQQTQPPAKQSNNP	CPSF4	181	O95639
PLQQQQQPPPQQKSL	GRM1	1016	Q13255
KFQQKQKIQQQQPPP	VARS1	246	P26640
QKIQQQQPPPGEKKP	VARS1	251	P26640
TPPPQLQQQQVKQPS	SPRR3	11	Q9UBC9
LQQQQVKQPSQPPPQ	SPRR3	16	Q9UBC9
QQKAQSLPQPQQQPP	RAPGEF2	1031	Q9Y4G8
PKPVQKPPKSNVNNN	STAU2	76	Q9NUL3
NQQPNQQPPGKKPFL	KIF20A	836	O95235
MNSQQQKQPCTPPPQ	SPRR1A	1	P35321
QKQPCTPPPQLQQQQ	SPRR1B	6	P22528
TPPPQLQQQQVKQPC	SPRR1B	11	P22528
LQQQQVKQPCQPPPQ	SPRR1B	16	P22528
QPKKVATPPNQNQKQ	TMEM214	91	Q6NUQ4
KQQQQLPQTLQPQPP	PRPF40B	181	Q6NWY9
QFHVQPQPQPKPQVQ	ZYX	221	Q15942
QEKQHPVPPPAQNQN	ZYX	326	Q15942
KQGQPKPELQQQEQP	ZFHX3	2446	Q15911