Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	chromatin remodeling	CARM1 BMI1 PCGF2 BRCA2 LIN54 BUB1 KDM6A ZFY TASOR2 TDRD12	2.69e-05	741	56	10	GO:0006338
MousePheno	abnormal prenatal growth/weight/body size	CARM1 TGFBR1 BMI1 SMG1 LIFR HK2 KITLG BRCA2 ABCA12 KDR CLPX CMTR2 ALG6 KDM6A ZFY EFTUD2	2.02e-06	1493	41	16	MP:0004196
MousePheno	abnormal prenatal body size	CARM1 TGFBR1 BMI1 SMG1 LIFR KITLG BRCA2 ABCA12 KDR CLPX ALG6 KDM6A ZFY	1.06e-05	1116	41	13	MP:0010866
MousePheno	abnormal embryonic growth/weight/body size	CARM1 TGFBR1 BMI1 SMG1 HK2 BRCA2 KDR CLPX CMTR2 ALG6 KDM6A ZFY EFTUD2	5.18e-05	1295	41	13	MP:0002088
MousePheno	perinatal lethality, incomplete penetrance	CARM1 PCGF2 KITLG BRCA2 BUB1 KDM6A ZFY EFTUD2	8.91e-05	503	41	8	MP:0011090
Domain	DUF4195	ZNF280D ZNF280C	5.47e-05	4	57	2	PF13836
Domain	DUF4195	ZNF280D ZNF280C	5.47e-05	4	57	2	IPR025243
Domain	ZINC_FINGER_C2H2_2	ZNF26 ZNF33A ZNF33B ZNF493 ZNF280D ZNF280C ZNF768 ZNF286A ZFY	5.24e-04	775	57	9	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF26 ZNF33A ZNF33B ZNF493 ZNF280D ZNF280C ZNF768 ZNF286A ZFY	5.34e-04	777	57	9	PS00028
Domain	Znf_C2H2-like	ZNF26 ZNF33A ZNF33B ZNF493 ZNF280D ZNF280C ZNF768 ZNF286A ZFY	6.35e-04	796	57	9	IPR015880
Domain	Znf_C2H2	ZNF26 ZNF33A ZNF33B ZNF493 ZNF280D ZNF280C ZNF768 ZNF286A ZFY	6.88e-04	805	57	9	IPR007087
Domain	ZnF_C2H2	ZNF26 ZNF33A ZNF33B ZNF493 ZNF280D ZNF280C ZNF768 ZNF286A ZFY	7.07e-04	808	57	9	SM00355
Domain	zf-C2H2	ZNF26 ZNF33A ZNF33B ZNF493 ZNF280D ZNF768 ZNF286A ZFY	1.14e-03	693	57	8	PF00096
Domain	GUANYLATE_CYCLASE_1	GUCY1B2 ADCY9	1.51e-03	19	57	2	PS00452
Domain	Guanylate_cyc	GUCY1B2 ADCY9	1.51e-03	19	57	2	PF00211
Domain	GUANYLATE_CYCLASE_2	GUCY1B2 ADCY9	1.51e-03	19	57	2	PS50125
Domain	A/G_cyclase	GUCY1B2 ADCY9	1.51e-03	19	57	2	IPR001054
Domain	CYCc	GUCY1B2 ADCY9	1.51e-03	19	57	2	SM00044
Domain	-	ZNF26 ZNF33A ZNF33B ZNF493 ZNF768 ZNF286A ZFY	4.44e-03	679	57	7	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF26 ZNF33A ZNF33B ZNF493 ZNF768 ZNF286A ZFY	5.00e-03	694	57	7	IPR013087
Pubmed	Polycomb genes expression as a predictor of poor clinical outcome in children with medulloblastoma.	BMI1 PCGF2	2.64e-06	2	57	2	20717685
Pubmed	Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis.	BMI1 PCGF2	2.64e-06	2	57	2	17452456
Pubmed	Expression and clinicopathological significance of Mel-18 and Bmi-1 mRNA in gastric carcinoma.	BMI1 PCGF2	2.64e-06	2	57	2	21059209
Pubmed	Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells.	BMI1 PCGF2	2.64e-06	2	57	2	17545584
Pubmed	BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer.	BMI1 PCGF2	2.64e-06	2	57	2	20170541
Pubmed	Expression of BMI-1 and Mel-18 in breast tissue--a diagnostic marker in patients with breast cancer.	BMI1 PCGF2	2.64e-06	2	57	2	21162745
Pubmed	Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas.	BMI1 PCGF2	7.91e-06	3	57	2	17145810
Pubmed	Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins.	BMI1 PCGF2	7.91e-06	3	57	2	17151361
Pubmed	Functional analysis of mouse Polycomb group genes.	BMI1 PCGF2	7.91e-06	3	57	2	9487388
Pubmed	Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth.	HK2 BRCA2	7.91e-06	3	57	2	25176644
Pubmed	Reciprocal expression of Bmi1 and Mel-18 is associated with functioning of primitive hematopoietic cells.	BMI1 PCGF2	7.91e-06	3	57	2	19409954
Pubmed	Impaired phosphorylation and mis-localization of Bub1 and BubR1 are responsible for the defective mitotic checkpoint function in Brca2-mutant thymic lymphomas.	BRCA2 BUB1	7.91e-06	3	57	2	14646599
Pubmed	Stage-specific expression of cytokine and receptor messenger ribonucleic acids in human preimplantation embryos.	LIFR KITLG	7.91e-06	3	57	2	8547494
Pubmed	A novel cysteine-rich sequence motif.	BMI1 PCGF2	7.91e-06	3	57	2	1991318
Pubmed	A novel zinc finger coiled-coil domain in a family of nuclear proteins.	BMI1 PCGF2	7.91e-06	3	57	2	1412709
Pubmed	Evidence for alteration of EZH2, BMI1, and KDM6A and epigenetic reprogramming in human papillomavirus type 16 E6/E7-expressing keratinocytes.	BMI1 KDM6A	7.91e-06	3	57	2	21865393
Pubmed	Hexokinase 2 (HK2), the tumor promoter in glioma, is downregulated by miR-218/Bmi1 pathway.	BMI1 HK2	7.91e-06	3	57	2	29220380
Pubmed	Regulation of hematopoietic stem cells using protein transduction domain-fused Polycomb.	BMI1 PCGF2	7.91e-06	3	57	2	22634509
Pubmed	Polycomb repressive complex 1 modulates granulosa cell proliferation in early folliculogenesis to support female reproduction.	BMI1 PCGF2	1.58e-05	4	57	2	38389850
Pubmed	Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex.	BMI1 PCGF2	1.58e-05	4	57	2	9009205
Pubmed	Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond.	BMI1 PCGF2	1.58e-05	4	57	2	9153995
Pubmed	High-throughput microarray detection of olfactory receptor gene expression in the mouse.	OR2M7 OR2M2	1.58e-05	4	57	2	15377787
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	CARM1 BMI1 PCGF2 ZNF280D LIN54 ZNF280C KDM6A	1.62e-05	495	57	7	27705803
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	CARM1 BMI1 KDM6A	2.20e-05	33	57	3	26864203
Pubmed	Activin receptor-like kinase 1 is essential for placental vascular development in mice.	TGFBR1 KDR	2.63e-05	5	57	2	17530030
Pubmed	Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1.	BMI1 PCGF2	2.63e-05	5	57	2	15589172
Pubmed	Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution.	ZNF33A ZNF33B	2.63e-05	5	57	2	8464732
Pubmed	Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF.	BMI1 PCGF2	2.63e-05	5	57	2	14560011
Pubmed	MOZ and BMI1 act synergistically to maintain hematopoietic stem cells.	BMI1 PCGF2	2.63e-05	5	57	2	27773671
Pubmed	Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes.	GUCY1B2 PDE5A	3.94e-05	6	57	2	19345227
Pubmed	Apelin+ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury.	KITLG KDR	3.94e-05	6	57	2	31761723
Pubmed	Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.	CARM1 BMI1 KDM6A	5.27e-05	44	57	3	24183668
Pubmed	Essential Role for Polycomb Group Protein Pcgf6 in Embryonic Stem Cell Maintenance and a Noncanonical Polycomb Repressive Complex 1 (PRC1) Integrity.	BMI1 PCGF2	5.51e-05	7	57	2	28049731
Pubmed	Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development.	TGFBR1 KDR	5.51e-05	7	57	2	16344855
Pubmed	Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice.	BMI1 PCGF2	5.51e-05	7	57	2	15964995
Pubmed	Topology and enzymatic properties of a canonical Polycomb repressive complex 1 isoform.	BMI1 PCGF2	5.51e-05	7	57	2	31093962
Pubmed	BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3.	BMI1 PCGF2	5.51e-05	7	57	2	28780076
Pubmed	REST interacts with Cbx proteins and regulates polycomb repressive complex 1 occupancy at RE1 elements.	BMI1 PCGF2	5.51e-05	7	57	2	21402785
Pubmed	BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase.	BMI1 PCGF2	7.34e-05	8	57	2	26151332
Pubmed	A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.	SMG1 TTI1	7.34e-05	8	57	2	20810650
Pubmed	Functional redundancy among Polycomb complexes in maintaining the pluripotent state of embryonic stem cells.	BMI1 PCGF2	7.34e-05	8	57	2	35364009
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	BMI1 GUCY1B2 BUB1 KDR ZMYM1 TASOR2	7.35e-05	430	57	6	35044719
Pubmed	Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs.	BMI1 PCGF2	9.43e-05	9	57	2	23523425
Pubmed	The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.	BMI1 PCGF2	1.18e-04	10	57	2	19585519
Pubmed	A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1.	BMI1 PCGF2	1.18e-04	10	57	2	20808772
Pubmed	Differential expression of polycomb repression complex 1 (PRC1) members in the developing mouse brain reveals multiple complexes.	BMI1 PCGF2	1.18e-04	10	57	2	16786585
Pubmed	Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8.	BMI1 PCGF2	1.18e-04	10	57	2	16687444
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	SMG1 TTI1	1.44e-04	11	57	2	20427287
Pubmed	Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice.	BMI1 PCGF2	1.44e-04	11	57	2	12183370
Pubmed	Defective paracrine signalling by TGFbeta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia.	TGFBR1 KDR	1.44e-04	11	57	2	15548578
Pubmed	c-kit delineates a distinct domain of progenitors in the developing kidney.	KITLG KDR	1.44e-04	11	57	2	16942767
Pubmed	Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.	BMI1 PCGF2	1.72e-04	12	57	2	19636380
Pubmed	Lsh controls Hox gene silencing during development.	BMI1 PCGF2	1.72e-04	12	57	2	17726103
Pubmed	Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor.	BMI1 PCGF2	1.72e-04	12	57	2	20543829
Pubmed	Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer.	BMI1 BUB1	2.03e-04	13	57	2	15931389
Pubmed	Mapping anti-müllerian hormone (Amh) and related sequences in the mouse: identification of a new region of homology between MMU10 and HSA19p.	KITLG ZFY	2.03e-04	13	57	2	1685136
Pubmed	PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification.	BMI1 PCGF2	2.03e-04	13	57	2	29727681
Pubmed	Overexpression of Polycomb-group gene rae28 in cardiomyocytes does not complement abnormal cardiac morphogenesis in mice lacking rae28 but causes dilated cardiomyopathy.	BMI1 PCGF2	2.03e-04	13	57	2	11950896
Pubmed	Searching QTL by gene expression: analysis of diabesity.	APOM KITLG SCP2	2.20e-04	71	57	3	15760467
Pubmed	PRC1 preserves epidermal tissue integrity independently of PRC2.	BMI1 PCGF2	2.37e-04	14	57	2	30567998
Pubmed	Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering.	ZNF33A ZNF33B	2.37e-04	14	57	2	2014798
Pubmed	Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor.	BMI1 PCGF2	2.73e-04	15	57	2	20601937
Pubmed	Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A.	BMI1 PCGF2	3.12e-04	16	57	2	16624538
Pubmed	The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.	BMI1 PCGF2	3.12e-04	16	57	2	12167701
Pubmed	Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation.	KDM6A ZFY	3.53e-04	17	57	2	19571810
Pubmed	Expression levels of endoglin distinctively identify hematopoietic and endothelial progeny at different stages of yolk sac hematopoiesis.	TGFBR1 KDR	3.53e-04	17	57	2	23712751
Pubmed	The Hemogenic Competence of Endothelial Progenitors Is Restricted by Runx1 Silencing during Embryonic Development.	BMI1 KDR	3.53e-04	17	57	2	27239041
Pubmed	Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis.	SMG1 KDR	3.53e-04	17	57	2	10428027
Pubmed	Sox9-Positive Progenitor Cells Play a Key Role in Renal Tubule Epithelial Regeneration in Mice.	BMI1 KITLG	3.97e-04	18	57	2	26776520
Pubmed	Sex differences in sex chromosome gene expression in mouse brain.	KDM6A ZFY	3.97e-04	18	57	2	12023983
Pubmed	Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression.	BMI1 PCGF2	3.97e-04	18	57	2	11290297
Pubmed	Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.	BMI1 PCGF2	4.43e-04	19	57	2	16359901
Pubmed	A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development.	TGFBR1 KDR	4.92e-04	20	57	2	12588999
Pubmed	Mesodermal deletion of transforming growth factor-beta receptor II disrupts lung epithelial morphogenesis: cross-talk between TGF-beta and Sonic hedgehog pathways.	TGFBR1 KDR	4.92e-04	20	57	2	18990706
Pubmed	Apoptosis regulator through modulating IAP expression (ARIA) controls the PI3K/Akt pathway in endothelial and endothelial progenitor cells.	TGFBR1 KDR	5.43e-04	21	57	2	21593423
Pubmed	SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.	BMI1 PCGF2	5.43e-04	21	57	2	37014752
Pubmed	PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos.	BMI1 PCGF2	5.43e-04	21	57	2	18311137
Pubmed	A protein interaction landscape of breast cancer.	HK2 BRCA2 ZMYM1 HSPBP1 CLPX ZNF768	5.91e-04	634	57	6	34591612
Pubmed	AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene.	KITLG KDR	5.97e-04	22	57	2	9811459
Pubmed	Cranial neural crest deletion of VEGFa causes cleft palate with aberrant vascular and bone development.	TGFBR1 KDR	6.53e-04	23	57	2	25759071
Pubmed	Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung.	TGFBR1 KDR	6.53e-04	23	57	2	28811219
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	TGFBR1 BMI1 BRCA2 KDR ZFY	6.54e-04	424	57	5	21731673
Pubmed	Positioning of five genes (CASK, ARX, SAT, IMAGE cDNAs 248928 and 253949) from the human X chromosome short arm with respect to evolutionary breakpoints on the mouse X chromosome.	KDM6A ZFY	8.36e-04	26	57	2	10920247
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	SMG1 TTI1	9.02e-04	27	57	2	23027611
Pubmed	Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.	TGFBR1 KDR	9.02e-04	27	57	2	35894043
Pubmed	Conditionals by inversion provide a universal method for the generation of conditional alleles.	TGFBR1 KDR	9.02e-04	27	57	2	23918385
Pubmed	SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination.	BMI1 PCGF2	9.02e-04	27	57	2	25703348
Pubmed	Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.	BMI1 PCGF2 ZNF33A	9.28e-04	116	57	3	21282530
Pubmed	Gene knockouts that cause female infertility: search for novel contraceptive targets.	KITLG ZFY	9.71e-04	28	57	2	15970507
Pubmed	Deficiency of MFSD7c results in microcephaly-associated vasculopathy in Fowler syndrome.	HK2 KDR	9.71e-04	28	57	2	32369449
Pubmed	AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.	SMG1 TTI1	1.04e-03	29	57	2	20371770
Pubmed	Characterising the dynamics of placental glycogen stores in the mouse.	HK2 KDR	1.04e-03	29	57	2	32798765
Pubmed	Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.	BMI1 PCGF2	1.11e-03	30	57	2	37158107
Pubmed	POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.	TGFBR1 LIFR ZNF26 RP1	1.12e-03	277	57	4	30745168
Pubmed	Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.	ZNF280D LIN54 ZNF280C	1.15e-03	125	57	3	32891193
Pubmed	Multiple genes encoding zinc finger domains are expressed in human T cells.	ZNF26 ZNF33B	1.19e-03	31	57	2	2288909
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	TTI1 CLPX ZNF768 EFTUD2	1.50e-03	300	57	4	28561026
Interaction	MPLKIP interactions	CARM1 BRCA2 SCP2 EFTUD2	2.74e-06	36	55	4	int:MPLKIP
Interaction	TTI2 interactions	RNF123 BRCA2 CD40 TTI1	2.02e-05	59	55	4	int:TTI2
GeneFamily	Ring finger proteins\|Polycomb group ring fingers	BMI1 PCGF2	1.05e-04	7	41	2	61
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF26 ZNF33A ZNF33B ZNF493 ZNF768 ZNF286A ZFY	1.05e-03	718	41	7	28
GeneFamily	Olfactory receptors, family 2	OR2M7 OR2M2 OR2V2	2.13e-03	113	41	3	149
CoexpressionAtlas	facebase_RNAseq_e10.5_MandArch_2500	TGFBR1 ACAP1 YPEL4 HK2 ZNF280D BRCA2 LIN54 BUB1 CD40 TTI1 ZMYM1 OR2V2 KDM6A	5.97e-05	1468	54	13	facebase_RNAseq_e10.5_MandArch_2500
CoexpressionAtlas	DevelopingKidney_e15.5_Endothelial cells_emap-29965_k-means-cluster#5_top-relative-expression-ranked_1000	TGFBR1 LIFR KITLG USP12	6.20e-05	84	54	4	gudmap_developingKidney_e15.5_Endothelial cells_1000_k5
Disease	Colorectal Carcinoma	TGFBR1 LIFR ACAP1 CLSTN3 ABCA12 BUB1 KDR KDM6A	2.95e-05	702	52	8	C0009402
Disease	Pathologic Neovascularization	BMI1 KDR	4.55e-05	6	52	2	C0027686
Disease	colorectal cancer (is_implicated_in)	TGFBR1 BUB1 KDR KDM6A	6.26e-05	121	52	4	DOID:9256 (is_implicated_in)
Disease	pulmonary hypertension (implicated_via_orthology)	TGFBR1 CD40 PDE5A	1.20e-04	54	52	3	DOID:6432 (implicated_via_orthology)
Disease	Myocardial Ischemia	RAB12 HK2 KITLG KDR	2.65e-04	176	52	4	C0151744
Disease	hepatocellular carcinoma (is_implicated_in)	BMI1 KDR KDM6A EFTUD2	2.95e-04	181	52	4	DOID:684 (is_implicated_in)
Disease	Uremia	TGFBR1 KDR	4.07e-04	17	52	2	C0041948
Disease	Malignant neoplasm of pancreas	BRCA2 BUB1 KDR	7.84e-04	102	52	3	C0346647
Disease	blood manganese measurement	FREM3 ADCY9	1.04e-03	27	52	2	EFO_0007581
Disease	Crohn's disease (is_marker_for)	CD40 KDR	1.20e-03	29	52	2	DOID:8778 (is_marker_for)
Disease	cancer (implicated_via_orthology)	ACAP1 BRCA2 TTI1 KDR	1.28e-03	268	52	4	DOID:162 (implicated_via_orthology)
Disease	Colorectal Neoplasms	TGFBR1 ABCA12 BUB1 KDR	1.44e-03	277	52	4	C0009404
Disease	melanoma (is_implicated_in)	BRCA2 CD40	1.65e-03	34	52	2	DOID:1909 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FSTICKICELSFETE	ZNF280D	386	Q6N043
ILFECSECKKTFTES	ZNF286A	296	Q9HBT8
KCVEEFKSLTSCLDS	APOM	156	O95445
LTTAVKCFSEESCVS	CLSTN3	611	Q9BQT9
IFTAKCETSGFQCVE	BUB1	961	O43683
ETFVSSTRFVKCEKC	CLPX	116	O76031
CVTSFSIFEKTSEEE	ALG6	401	Q9Y672
CESETFSLIEKSCQL	ABCA12	441	Q86UK0
SEELIFSELCSLTEC	CMTR2	551	Q8IYT2
RFCFEVVSTSKSCLL	ACAP1	326	Q15027
RFTDDTFCEACKSTV	RAB12	61	Q6IQ22
FTFVTKEVAEATCNC	LIN54	686	Q6MZP7
IFTDLLCKSIQTSCE	EYS	361	Q5T1H1
CSICEVEVFDLLFVT	KDM6A	1331	O15550
IDATTIIECLHSFCK	BMI1	26	P35226
DVCVFKCSVSRETEC	CARM1	76	Q86X55
STCDDSIIVKEVCTV	HK2	811	P52789
DTSIFEEVIFICCIV	OR2M2	191	Q96R28
DTSIFEEVIFICCIV	OR2M7	191	Q8NG81
VDTSLFEKVIFACCV	OR2V2	191	Q96R30
KCTIFIVDEDCSDSF	PDE5A	366	O76074
KATTEELFTCQETVC	PPP1R3A	696	Q16821
IDATTIVECLHSFCK	PCGF2	26	P35227
TCVAATTFQKVLDEC	EVA1C	111	P58658
DTSEEDSFSLCFSKC	BRCA2	301	P51587
FDRLCEETKCEKIST	ADCY9	426	O60503
TKFESNVCVCDFSIE	ANKMY1	466	Q9P2S6
DITFCCVSQEKVLSA	LIFR	266	P42702
EVCSLTDTVFSDKAC	RP1	1301	P56715
IFIEDTITDCKQSAC	FREM3	2121	P0C091
EELEFCEKLLQTCFS	HSPBP1	336	Q9NZL4
FTCSVAETEIVCKVV	TDRD12	681	Q587J7
DCCISSFDKSVLTLA	SMG1	1136	Q96Q15
EFKSCTILFSDVVTF	GUCY1B2	386	O75343
FKDFVVASETSDCVV	KITLG	151	P21583
ASKEVFDFLTILQCC	SCP2	211	P22307
FTCVTDGLCFVSVTE	TGFBR1	46	P36897
VAISFDRCKITSVTC	ZSWIM5	221	Q9P217
EFSDCEKFLCVKSTL	ZNF33B	276	Q06732
KDCFFCKTTIVSVED	RNF123	1286	Q5XPI4
KDVCSECTSFVADVV	SPIRE2	666	Q8WWL2
CLTCETISSKDEDFL	USP12	186	O75317
CEVCSKAFSQSSDLI	ZNF768	291	Q9H5H4
ETCFLDCVKDFTTRE	TIMM9	26	Q9Y5J7
ATCNTFITTLEECVK	PLEKHA3	161	Q9HB20
FSDCEKFLCVKSTLS	ZNF33A	276	Q06730
SVADIFCESCKTTLG	YPEL4	81	Q96NS1
SCSECEKVFSFRSQL	ZNF26	231	P17031
CEECGKAFSIFSTLT	ZNF493	251	Q6ZR52
CEECGKAFSIFSTLT	ZNF493	531	Q6ZR52
VLSCDDSVKITFKCE	TASOR2	736	Q5VWN6
VTECSDGLFCKTLTI	KDR	76	P35968
FSTICKICELSFETE	ZNF280C	381	Q8ND82
VQLEDTTSCKTFCSL	ZMYM1	151	Q5SVZ6
TFCETVVETSSLKCF	EFTUD2	661	Q15029
KLVSDCTEFTETECL	CD40	46	P25942
ECLTFVLSSTCVKEQ	TTI1	76	O43156
FKCDICLLTFSDTKE	ZFY	601	P08048