Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	zf-MYND	ZMYND8 ANKMY1	1.79e-03	21	56	2	PF01753
Domain	Znf_MYND	ZMYND8 ANKMY1	1.96e-03	22	56	2	IPR002893
Domain	ZF_MYND_1	ZMYND8 ANKMY1	1.96e-03	22	56	2	PS01360
Domain	ZF_MYND_2	ZMYND8 ANKMY1	1.96e-03	22	56	2	PS50865
Domain	SMAD_FHA_domain	SLMAP DUSP15	1.06e-02	52	56	2	IPR008984
Pubmed	Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination.	ATR FANCI	8.48e-06	3	59	2	34828369
Pubmed	DUSP15 expression is reduced in the hippocampus of Myrf knock-out mice but attention and object recognition memory remain intact.	DUSP15 MYRF	8.48e-06	3	59	2	36730342
Pubmed	Deficiency in IL-17-committed Vγ4(+) γδ T cells in a spontaneous Sox13-mutant CD45.1(+) congenic mouse substrain provides protection from dermatitis.	PTPRC SOX13	8.48e-06	3	59	2	23624556
Pubmed	FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway.	ATR FANCI	1.69e-05	4	59	2	18931676
Pubmed	ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress.	ATR FANCI	2.82e-05	5	59	2	25843623
Pubmed	ATR-ATRIP kinase complex triggers activation of the Fanconi anemia DNA repair pathway.	ATR FANCI	4.23e-05	6	59	2	22258451
Pubmed	The Dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in Myelinating Oligodendrocytes.	DUSP15 MYRF	5.91e-05	7	59	2	27532821
Pubmed	Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.	RIMBP3 GJA5 PDE4B ZMIZ2 FAM131C MEOX2	6.17e-05	402	59	6	24722188
Pubmed	Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).	ATR FANCI KDM4B	1.14e-04	55	59	3	27114453
Pubmed	A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.	ATR FANCI	1.26e-04	10	59	2	17478428
Pubmed	Cdk12 is essential for embryonic development and the maintenance of genomic stability.	ATR FANCI	1.26e-04	10	59	2	26658019
Pubmed	Interleukin-11 signaling is required for the differentiation of natural killer cells at the maternal-fetal interface.	PTPRC ENG	1.54e-04	11	59	2	15499555
Pubmed	Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos.	PTPRC ENG	1.54e-04	11	59	2	20876651
Pubmed	14-3-3epsilon controls multiple developmental processes in the mouse heart.	GJA5 ENG	1.54e-04	11	59	2	27580238
Pubmed	Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.	PTPRC ATR	1.54e-04	11	59	2	11551930
Pubmed	Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes.	MYRF SOX13	1.85e-04	12	59	2	26525805
Pubmed	HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.	ATR FANCI	1.85e-04	12	59	2	24005329
Pubmed	The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features.	ATR FANCI	2.93e-04	15	59	2	19536649
Pubmed	Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex.	ATR FANCI	2.93e-04	15	59	2	27073218
Pubmed	A blood capillary plexus-derived population of progenitor cells contributes to genesis of the dermal lymphatic vasculature during embryonic development.	GJA5 PTPRC	2.93e-04	15	59	2	29773646
Pubmed	Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential.	GJA5 ENG	2.93e-04	15	59	2	28195173
Pubmed	The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1+ hematoendothelial progenitors.	PTPRC MEOX2	3.34e-04	16	59	2	33454424
Pubmed	Analysis of Placental Arteriovenous Formation Reveals New Insights Into Embryos With Congenital Heart Defects.	GJA5 ENG	3.79e-04	17	59	2	35126469
Pubmed	Connexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothorax.	GJA5 PTPRC	3.79e-04	17	59	2	21515254
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	TBC1D32 SLMAP MTCL1 KDM4B PPP6R3	4.20e-04	371	59	5	15747579
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	COBL MTCL1 PPP6R3 HELB	4.45e-04	209	59	4	36779422
Pubmed	Lymph sacs are not required for the initiation of lymph node formation.	PTPRC ENG	4.75e-04	19	59	2	19060331
Pubmed	Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function.	PTPRC CIITA	5.27e-04	20	59	2	19234195
Pubmed	Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp.	PTPRC ENG	5.27e-04	20	59	2	30988302
Pubmed	Fgf9 signaling regulates small intestinal elongation and mesenchymal development.	PTPRC ENG	5.27e-04	20	59	2	18653563
Pubmed	ETAA1 acts at stalled replication forks to maintain genome integrity.	ATR HELB	5.82e-04	21	59	2	27723720
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SEMA6D PRRC2C COBL MTCL1 EPG5	6.38e-04	407	59	5	12693553
Pubmed	Mechanical load regulates bone growth via periosteal Osteocrin.	PTPRC ENG	6.39e-04	22	59	2	34260913
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	ATR USH2A MYRF EPG5	6.69e-04	233	59	4	32290105
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SLMAP PPP6R3 EPG5	6.87e-04	101	59	3	10997877
Pubmed	A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells.	ATR USH2A EPG5	7.69e-04	105	59	3	23284306
Pubmed	The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.	COBL SOX13	8.28e-04	25	59	2	35874829
Pubmed	ATR maintains select progenitors during nervous system development.	ATR MEOX2	8.28e-04	25	59	2	22266795
Pubmed	Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.	PRRC2C FANCI SLMAP MASTL PPP6R3	8.34e-04	432	59	5	23455922
Pubmed	Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.	MTCL1 EPG5	9.66e-04	27	59	2	18649358
Pubmed	FOXO1 represses sprouty 2 and sprouty 4 expression to promote arterial specification and vascular remodeling in the mouse yolk sac.	SPRY3 GJA5	1.04e-03	28	59	2	35297995
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	FSIP2 PRRC2C ZMYND8	1.21e-03	123	59	3	26912792
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ZMIZ2 ZMYND8 SOX13 ZFAND4 KDM4B MEOX2	1.27e-03	709	59	6	22988430
Pubmed	STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.	MTCL1 PPP6R3	1.27e-03	31	59	2	28089446
Pubmed	Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line.	PTPRC ATR	1.44e-03	33	59	2	24569637
Cytoband	2q32.1	FSIP2 OSBPL6	6.90e-04	30	59	2	2q32.1
GeneFamily	Zinc fingers MYND-type	ZMYND8 ANKMY1	7.47e-04	21	35	2	87
Disease	phosphatidylethanolamine measurement	SEMA6D USH2A MYRF MEOX2	3.30e-04	173	56	4	EFO_0010228
Disease	Gastro-enteropancreatic neuroendocrine tumor	PTPRC CIITA	3.66e-04	15	56	2	C2930967
Disease	neuropsychological test	TBC1D32 GJA5 FAM131C RFX4	5.40e-04	197	56	4	EFO_0003926
Disease	retinitis pigmentosa (implicated_via_orthology)	USH2A EPG5	1.20e-03	27	56	2	DOID:10584 (implicated_via_orthology)
Disease	red blood cell density measurement	GJA5 PRDM8 PTPRC ATR CIITA ENG MYRF	1.33e-03	880	56	7	EFO_0007978
Disease	pursuit maintenance gain measurement	SPATA31C2 ANKMY1 EPG5	1.67e-03	123	56	3	EFO_0008433
Disease	oppositional defiant disorder measurement	TTLL8 S1PR3	2.14e-03	36	56	2	EFO_0007679
Disease	skin pigmentation measurement	SEMA6D NOX4 USH2A	2.27e-03	137	56	3	EFO_0007009
Disease	QT interval	PRDM8 PDE4B OSBPL6 MYRF PPP6R3	3.41e-03	534	56	5	EFO_0004682

Protein segments in the cluster

Peptide	Gene	Start	Entry
NSSPHPETRSMIVCL	EPG5	2106	Q9HCE0
SPSCPKMTSAAHSEN	TBC1D32	476	Q96NH3
MTEHKTSPTQCPAAG	CIITA	311	P33076
TPTQKRRSCMPHQQT	MASTL	696	Q96GX5
DSPPSLSTHFMKKCN	AASDH	91	Q4L235
SSSSPQRKKVHCLNM	ENG	431	P17813
SNMAKPRAPSCRTVH	ATP10D	491	Q9P241
QLPCMRNTHVPSSSV	RFX4	571	Q33E94
TMTSPEHCQKQPLRS	MTCL1	1486	Q9Y4B5
TSPSLSRMPNQHACK	FANCI	406	Q9NVI1
KPMAQRSAHCSRPSG	CSNK1G1	16	Q9HCP0
NKPNCIMSLTGHTSP	KATNB1	51	Q9BVA0
NKSFSMHRNNSVPLC	FSIP2	3631	Q5CZC0
PKAMSRNSSLPSEQH	PDE4B	146	Q07343
LSNMHDLSSNSKPRC	DEPDC1	406	Q5TB30
HGAQNPSCKIMTFRP	KDM4B	6	O94953
APLKCPLADTHMNSS	LRRC42	346	Q9Y546
QMSSPPSAARHSLCL	MEOX2	96	P50222
TQLHKLARSPCSPDM	MROH6	271	A6NGR9
MSPVRLHSSNPNLCA	OSBPL6	336	Q9BZF3
NHPFTLTMCPTETKA	NOX4	351	Q9NPH5
CSSSVAPSQHLQPMA	HOXD4	231	P09016
PPYSSKTRSQVMNCH	SLC51A	286	Q86UW1
LHSSQMTALPNTPCQ	ATR	941	Q13535
HRNPVSMETKSSCLP	ICE2	951	Q659A1
NPALQIGSHPMCKSS	CARD6	926	Q9BX69
PRQHMAKCQLSGPSV	GJA5	241	P36382
HRTSKTSGAQCPPMT	DUSP15	146	Q9H1R2
LISKTPCMPQAASNT	GPR148	21	Q8TDV2
KGCLTTPNSPSMHSR	COBL	261	O75128
SRDLFTSAHKNCPMP	FAM131C	6	Q96AQ9
QSHSLLKMASPSPCT	ANKMY1	491	Q9P2S6
PEHMKSCTQSATAPQ	ZMYND8	1056	Q9ULU4
PHTAPSSCIMDKNAA	S1PR3	356	Q99500
ATQMPCSLDKPHRSS	POLRMT	586	O00411
SDMSPPNQKHICALF	HELB	116	Q8NG08
NNSDTLRLPKMSSCP	FBXL21P	201	Q9UKT6
HCLVPKMPTNSTETT	GARIN1A	191	Q6NXP2
AKALHRMSPTPNSCP	NUTM2A	46	Q8IVF1
NHKSCFSSPPSPKLM	USH2A	131	O75445
HMPERLQASSPACKQ	SPATA31C2	726	B4DYI2
ENCSQHMGTSKSPAP	RIMBP3	1311	Q9UFD9
CPSRSHNKMNGSSPY	PRDM8	141	Q9NQV8
SLPSASHFSQLSCMP	PRRC2C	2351	Q9Y520
HSLTKRPNCSSMSSL	POM121L2	226	Q96KW2
ATMPTSLPRSLSQCH	SPRY3	56	O43610
PESRNSSHIKRPMNA	SOX13	416	Q9UN79
TMHPSTPVTAQLCAQ	TTLL8	546	A6PVC2
KDMLNTPLCPSHSSL	RNPC3	286	Q96LT9
MPSALAIFTCRPNSH	SLMAP	1	Q14BN4
ESSQAQSCMSPPQKH	TSHZ2	776	Q9NRE2
QSCMSPPQKHALSDI	TSHZ2	781	Q9NRE2
KSTACLPSQMAPAGH	ZMIZ2	796	Q8NF64
SSTMKPNTKCHSPER	TSGA10	661	Q9BZW7
RCSAPMSLHNSLVKP	ZFAND4	476	Q86XD8
RHSISAMPKNLNSPN	SEMA6D	971	Q8NFY4
PAKKHPSASMSCQRQ	TMEM202	31	A6NGA9
PPGMSHSACSVNKSV	PPP6R3	291	Q5H9R7
TSDNSMHVKCRPPRD	PTPRC	496	P08575
RKHSESPPSTLNAQM	MYRF	256	Q9Y2G1