Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	dendrite	SEMA4F PDE2A RTN4R GRIA4 GRIN1 CHRM2 MAPK8IP3 KHSRP IFNGR1 KCNC2 LZTS1 SKOR1 NGF ROBO1 GRIP2 TRAK2 GNAS HTT	1.55e-04	858	165	18	GO:0030425
GeneOntologyCellularComponent	dendritic tree	SEMA4F PDE2A RTN4R GRIA4 GRIN1 CHRM2 MAPK8IP3 KHSRP IFNGR1 KCNC2 LZTS1 SKOR1 NGF ROBO1 GRIP2 TRAK2 GNAS HTT	1.60e-04	860	165	18	GO:0097447
GeneOntologyCellularComponent	leading edge membrane	ERBB2 EPS8L2 GRIN1 MAPK8IP3 MTMR6 KCNC2 ROBO1 FGD5	2.71e-04	210	165	8	GO:0031256
GeneOntologyCellularComponent	somatodendritic compartment	SEMA4F PDE2A SNPH RTN4R GRIA4 GRIN1 CIT CHRM2 MAPK8IP3 KHSRP JAM2 IFNGR1 KCNC2 LZTS1 SKOR1 NGF ROBO1 PRKN GRIP2 TRAK2 GNAS HTT	2.71e-04	1228	165	22	GO:0036477
GeneOntologyCellularComponent	cell body	SEMA4F SNPH RTN4R GRIA4 GRIN1 CIT CHRM2 MAPK8IP3 KHSRP KCNC2 LZTS1 SKOR1 ROBO1 PRKN GRIP2 TRAK2 GNAS HTT	4.06e-04	929	165	18	GO:0044297
GeneOntologyCellularComponent	axolemma	MAPK8IP3 KCNC2 ROBO1	5.79e-04	21	165	3	GO:0030673
GeneOntologyCellularComponent	synaptic membrane	SEMA4F SEMA4B ERBB2 PDE2A SNPH GRIA4 GRIN1 CHRM2 KCNC2 LZTS1 GRIP2 ADGRL2 HTT	7.53e-04	583	165	13	GO:0097060
GeneOntologyCellularComponent	neuronal cell body	SEMA4F SNPH RTN4R GRIA4 GRIN1 CIT CHRM2 KHSRP KCNC2 SKOR1 ROBO1 PRKN GRIP2 TRAK2 GNAS HTT	9.65e-04	835	165	16	GO:0043025
Domain	TSP_3	COMP THBS1 THBS3	6.93e-06	5	167	3	PF02412
Domain	TSP3	COMP THBS1 THBS3	6.93e-06	5	167	3	PS51234
Domain	TSP_CTER	COMP THBS1 THBS3	6.93e-06	5	167	3	PS51236
Domain	Thrombospondin_3_rpt	COMP THBS1 THBS3	6.93e-06	5	167	3	IPR017897
Domain	TSP_type-3_rpt	COMP THBS1 THBS3	6.93e-06	5	167	3	IPR028974
Domain	-	COMP THBS1 THBS3	6.93e-06	5	167	3	4.10.1080.10
Domain	Thrombospondin_C	COMP THBS1 THBS3	6.93e-06	5	167	3	IPR008859
Domain	TSP_C	COMP THBS1 THBS3	6.93e-06	5	167	3	PF05735
Domain	Thrombospondin_3-like_rpt	COMP THBS1 THBS3	6.93e-06	5	167	3	IPR003367
Domain	COMP	COMP THBS3	2.37e-04	3	167	2	PF11598
Domain	Thbs/COMP_coiled-coil	COMP THBS3	2.37e-04	3	167	2	IPR024665
Domain	TSP_1	THSD7A THSD7B ADAMTS10 THBS1 ADAMTS6	2.49e-04	63	167	5	PF00090
Domain	TSP1	THSD7A THSD7B ADAMTS10 THBS1 ADAMTS6	2.88e-04	65	167	5	SM00209
Domain	TSP1_rpt	THSD7A THSD7B ADAMTS10 THBS1 ADAMTS6	2.88e-04	65	167	5	IPR000884
Domain	TSP1	THSD7A THSD7B ADAMTS10 THBS1 ADAMTS6	2.88e-04	65	167	5	PS50092
Domain	DNA_pol_B	POLD1 POLE	4.71e-04	4	167	2	PF00136
Domain	DNA-dir_DNA_pol_B	POLD1 POLE	4.71e-04	4	167	2	IPR006172
Domain	DNA-dir_DNA_pol_B_exonuc	POLD1 POLE	4.71e-04	4	167	2	IPR006133
Domain	DNA-dir_DNA_pol_B_multi_dom	POLD1 POLE	4.71e-04	4	167	2	IPR006134
Domain	DNA_pol_B_exo1	POLD1 POLE	4.71e-04	4	167	2	PF03104
Domain	POLBc	POLD1 POLE	4.71e-04	4	167	2	SM00486
Domain	EGF_CA	COMP JAG2 SNED1 THBS1 THBS3 FBN3	8.03e-04	122	167	6	SM00179
Domain	-	RNASEH2A POLD1 POLE POLQ	8.15e-04	47	167	4	3.30.420.10
Domain	EGF-like_Ca-bd_dom	COMP JAG2 SNED1 THBS1 THBS3 FBN3	8.74e-04	124	167	6	IPR001881
Domain	EGF_CA	COMP JAG2 THBS1 THBS3 FBN3	1.05e-03	86	167	5	PF07645
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	THSD7A THSD7B ADAMTS10 THBS1 ADAMTS6	1.66e-05	39	117	5	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	THSD7A THSD7B ADAMTS10 THBS1 ADAMTS6	1.66e-05	39	117	5	MM15165
Pathway	WP_INFLAMMATORY_RESPONSE_PATHWAY	ZAP70 THBS1 THBS3 COL1A1	1.05e-04	30	117	4	M39641
Pathway	WP_INFLAMMATORY_RESPONSE_PATHWAY	ZAP70 THBS1 THBS3 COL1A1	1.05e-04	30	117	4	MM15812
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SEMA4F FAM193B SEMA4B ERBB2 PDE2A SHROOM3 PLOD3 POLE FBRSL1 GEMIN5 CHD8 BCL9 CIT MAPK8IP3 MPRIP JAG2 ARHGEF40 SETD5 ZNF408 ZNF516 TNKS1BP1 CABIN1 ADAT1 RAI1 HTT COL1A1	4.00e-11	1105	171	26	35748872
Pubmed	Interaction network of human early embryonic transcription factors.	ZNF131 TSHZ3 ZNF609 ZNF423 FBRSL1 CHD8 BCL9 HOXB9 ZNF516 ASXL2 UHRF2 RAI1	1.94e-07	351	171	12	38297188
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FNIP2 SNPH ZNF423 FRMPD1 EPG5 SETD5 ZFR2 PPIP5K1 CHPF2 BOD1L1 ASXL2 TRAK2	9.28e-07	407	171	12	12693553
Pubmed	Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability.	COMP THBS1 THBS3	1.16e-06	5	171	3	30622267
Pubmed	Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen.	COMP THBS1 THBS3	1.16e-06	5	171	3	18467703
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ERBB2 SHROOM3 ZNF609 RNMT KDM5C FBRSL1 CHD8 NACAD GTF3C2 ZNF516 TNKS1BP1 ADGRL2 RAI1	2.44e-06	529	171	13	14621295
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	PDE2A SHROOM3 GRIA4 CHD8 GRIN1 BCL9 CIT MAPK8IP3 KHSRP MPRIP LZTS1 ICAM5 ZNF516 UBA6 CABIN1 RASAL2 RAI1	6.02e-06	963	171	17	28671696
Pubmed	Thrombospondins 1 and 2 are important for afferent synapse formation and function in the inner ear.	COMP THBS1 THBS3	6.42e-06	8	171	3	24460873
Pubmed	Praja1 RING-finger E3 ubiquitin ligase is a common suppressor of neurodegenerative disease-associated protein aggregation.	RNF220 PRKN HTT	9.60e-06	9	171	3	35701899
Pubmed	The LMO2 oncogene regulates DNA replication in hematopoietic cells.	POLD1 GTF3C2 ITM2B RAI1 CAPN15	1.01e-05	58	171	5	26764384
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZNF131 TSHZ3 CHD8 RRP1 RNF220 HOXB9 SCML2 GTF3C2 BOD1L1 UHRF2 CABIN1 RAI1 DNMT3A	1.09e-05	608	171	13	36089195
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SEMA4B THSD7B SETD5 TNKS1BP1 ASXL2 GRIP2	1.18e-05	102	171	6	11214970
Pubmed	N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.	ZNF175 EMILIN2 MPRIP PPARGC1B SETD5 ZNF516 BOD1L1 PLCB3	1.30e-05	217	171	8	34048709
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	RARS1 GEMIN5 CHD8 KHSRP MPRIP MTMR6 SCML2 GTF3C2 ICAM5 TNKS1BP1 BOD1L1 HTT	1.93e-05	549	171	12	38280479
Pubmed	Combined mismatch repair and POLE/POLD1 defects explain unresolved suspected Lynch syndrome cancers.	POLD1 POLE	2.40e-05	2	171	2	26648449
Pubmed	Polymerase proofreading-associated polyposis: a new, dominantly inherited syndrome of hereditary colorectal cancer predisposition.	POLD1 POLE	2.40e-05	2	171	2	24509466
Pubmed	Increased somatic mutation burdens in normal human cells due to defective DNA polymerases.	POLD1 POLE	2.40e-05	2	171	2	34594041
Pubmed	The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry.	NGF MOG	2.40e-05	2	171	2	26347141
Pubmed	Long patch base excision repair with purified human proteins. DNA ligase I as patch size mediator for DNA polymerases delta and epsilon.	POLD1 POLE	2.40e-05	2	171	2	10559260
Pubmed	Role of POLE and POLD1 in familial cancer.	POLD1 POLE	2.40e-05	2	171	2	32792570
Pubmed	Human mismatch repair system balances mutation rates between strands by removing more mismatches from the lagging strand.	POLD1 POLE	2.40e-05	2	171	2	28512192
Pubmed	Germline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancers.	POLD1 POLE	2.40e-05	2	171	2	23447401
Pubmed	PGC-1β regulates HER2-overexpressing breast cancer cells proliferation by metabolic and redox pathways.	ERBB2 PPARGC1B	2.40e-05	2	171	2	26602383
Pubmed	Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis.	SHROOM3 COL1A1	2.40e-05	2	171	2	25437874
Pubmed	Tumor-Infiltrating Lymphocytes, Tumor Mutational Burden, and Genetic Alterations in Microsatellite Unstable, Microsatellite Stable, or Mutant POLE/POLD1 Colon Cancer.	POLD1 POLE	2.40e-05	2	171	2	34250404
Pubmed	Expression and initial characterization of recombinant mouse thrombospondin 1 and thrombospondin 3.	THBS1 THBS3	2.40e-05	2	171	2	8654563
Pubmed	The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signalling.	ERBB2 HTT	2.40e-05	2	171	2	23300147
Pubmed	POLE/POLD1 mutation in non-exonuclease domain matters for predicting efficacy of immune-checkpoint-inhibitor therapy.	POLD1 POLE	2.40e-05	2	171	2	34586735
Pubmed	Mutation spectrum of POLE and POLD1 mutations in South East Asian women presenting with grade 3 endometrioid endometrial carcinomas.	POLD1 POLE	2.40e-05	2	171	2	26748215
Pubmed	POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance.	POLD1 POLE	2.40e-05	2	171	2	26133394
Pubmed	Race, Prevalence of POLE and POLD1 Alterations, and Survival Among Patients With Endometrial Cancer.	POLD1 POLE	2.40e-05	2	171	2	38231514
Pubmed	Homozygosity mapping of a Weill-Marchesani syndrome locus to chromosome 19p13.3-p13.2.	ADAMTS10 FBN3	2.40e-05	2	171	2	11941487
Pubmed	Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.	POLD1 POLE	2.40e-05	2	171	2	23263490
Pubmed	Short CCG repeat in huntingtin gene is an obstacle for replicative DNA polymerases, potentially hampering progression of replication fork.	POLD1 POLE	2.40e-05	2	171	2	26271349
Pubmed	Intermolecular interactions of thrombospondins drive their accumulation in extracellular matrix.	COMP THBS1	2.40e-05	2	171	2	25995382
Pubmed	POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East.	POLD1 POLE	2.40e-05	2	171	2	32567205
Pubmed	POLE/POLD1 mutation and tumor immunotherapy.	POLD1 POLE	2.40e-05	2	171	2	35780178
Pubmed	DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer.	POLD1 POLE	2.40e-05	2	171	2	23528559
Pubmed	New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis.	POLD1 POLE	2.40e-05	2	171	2	24501277
Pubmed	Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity.	POLD1 POLE	2.40e-05	2	171	2	35817971
Pubmed	Lysyl hydroxylase 3-mediated glucosylation in type I collagen: molecular loci and biological significance.	PLOD3 COL1A1	2.40e-05	2	171	2	22573318
Pubmed	Ionotropic glutamate receptor expression in human white matter.	GRIA4 GRIN1	2.40e-05	2	171	2	27443784
Pubmed	ADAMTS-10 and -6 differentially regulate cell-cell junctions and focal adhesions.	ADAMTS10 ADAMTS6	2.40e-05	2	171	2	27779234
Pubmed	Rare germline variants in POLE and POLD1 encoding the catalytic subunits of DNA polymerases ε and δ in glioma families.	POLD1 POLE	2.40e-05	2	171	2	37990341
Pubmed	Thrombospondin 3 is a developmentally regulated heparin binding protein.	THBS1 THBS3	2.40e-05	2	171	2	8288588
Pubmed	DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors.	POLD1 POLE	2.40e-05	2	171	2	38219146
Pubmed	Comprehensive analysis of POLE and POLD1 Gene Variations identifies cancer patients potentially benefit from immunotherapy in Chinese population.	POLD1 POLE	2.40e-05	2	171	2	31673068
Pubmed	Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer.	POLD1 POLE	2.40e-05	2	171	2	25370038
Pubmed	Do HOXB9 and COL1A1 genes play a role in congenital dislocation of the hip? Study in a Caucasian population.	HOXB9 COL1A1	2.40e-05	2	171	2	19341834
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	SHROOM3 THSD7A EPG5 THBS1 SPINK5	2.71e-05	71	171	5	33541421
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	THSD7A THSD7B ADAMTS10 THBS1 ADAMTS6	3.54e-05	75	171	5	20637190
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ERBB2 ZNF609 RNASEH2A RBL1 POLD1 KDM5C BTBD18 FBRSL1 CHD8 MLKL ARHGEF40 SETD5 CHPF2 USP54 ADGRL2 FHL3 RAI1	3.94e-05	1116	171	17	31753913
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	KDM5C R3HCC1 CHD8 MPRIP THBS1 SETD5 DSTYK TNKS1BP1 ADGRL2	4.25e-05	332	171	9	37433992
Pubmed	Tagging genes with cassette-exchange sites.	ZFAT RARS1 ZNF423 TM7SF3 GEMIN5 CHD8 CIT JAM2 RNF220	4.55e-05	335	171	9	15741177
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	GRIA4 GRIN1 CIT MAPK8IP3 TNKS1BP1 ITM2B FAM131B	5.76e-05	197	171	7	36604605
Pubmed	Extracellular matrix retention of thrombospondin 1 is controlled by its conserved C-terminal region.	COMP THBS1	7.19e-05	3	171	2	18285447
Pubmed	Genome-wide study of hypomethylated and induced genes in patients with liver cancer unravels novel anticancer targets.	RNMT RASAL2	7.19e-05	3	171	2	24763612
Pubmed	A glial-specific voltage-sensitive Na channel gene maps close to clustered genes for neuronal isoforms on mouse chromosome 2.	THBS1 SCN7A	7.19e-05	3	171	2	8250913
Pubmed	Pathological Significance and Prognostic Roles of Thrombospondin-3, 4 and 5 in Bladder Cancer.	COMP THBS3	7.19e-05	3	171	2	33910854
Pubmed	Segregation of replicative DNA polymerases during S phase: DNA polymerase ε, but not DNA polymerases α/δ, are associated with lamins throughout S phase in human cells.	POLD1 POLE	7.19e-05	3	171	2	22887995
Pubmed	NFM Cross-Reactivity to MOG Does Not Expand a Critical Threshold Level of High-Affinity T Cells Necessary for Onset of Demyelinating Disease.	IFNGR1 MOG	7.19e-05	3	171	2	28887429
Pubmed	Thrombospondin-1, -2 and -5 have differential effects on vascular smooth muscle cell physiology.	COMP THBS1	7.19e-05	3	171	2	26168731
Pubmed	Genetic diagnosis in Sudanese and Tunisian families with syndromic intellectual disability through exome sequencing.	ADAT3 CCDC82	7.19e-05	3	171	2	35118659
Pubmed	Parkinson's disease-linked Parkin mutations impair glutamatergic signaling in hippocampal neurons.	GRIN1 PRKN	7.19e-05	3	171	2	30200940
Pubmed	mRNA Expression of thrombospondin 1, 2 and 3 from proximal to distal in human abdominal aortic aneurysm - preliminary report.	THBS1 THBS3	7.19e-05	3	171	2	34669362
Pubmed	Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers.	THBS1 THBS3	7.19e-05	3	171	2	1459996
Pubmed	Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age.	FGD5 COL1A1	7.19e-05	3	171	2	36961818
Pubmed	Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging.	FGD5 COL1A1	7.19e-05	3	171	2	30561324
Pubmed	The function of DNA polymerases in DNA repair synthesis of ultraviolet-irradiated human fibroblasts.	POLD1 POLE	7.19e-05	3	171	2	1730053
Pubmed	Inhibition of DNA Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity.	HTT DNMT3A	7.19e-05	3	171	2	27516062
Pubmed	Differential expression of thrombospondin 1, 2, and 3 during murine development.	THBS1 THBS3	7.19e-05	3	171	2	8400410
Pubmed	ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1.	COMP THBS1	7.19e-05	3	171	2	25712208
Pubmed	Expression and function of thrombospondin-1 in myelinating glial cells of the central nervous system.	THBS1 THBS3	7.19e-05	3	171	2	9373030
Pubmed	The number and distribution of AMPA receptor channels containing fast kinetic GluA3 and GluA4 subunits at auditory nerve synapses depend on the target cells.	GRIA4 ICAM5	7.19e-05	3	171	2	28397107
Pubmed	Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions.	SNPH PRKN	7.19e-05	3	171	2	28472658
Pubmed	Distinctive activities of DNA polymerases during human DNA replication.	POLD1 POLE	7.19e-05	3	171	2	16762037
Pubmed	Thrombospondin-1 opens the paracellular pathway in pulmonary microvascular endothelia through EGFR/ErbB2 activation.	ERBB2 THBS1	7.19e-05	3	171	2	21531776
Pubmed	Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome.	POLD1 POLE	7.19e-05	3	171	2	28218421
Pubmed	Development of ventricular trabeculae affects electrical conduction in the early endothermic heart.	ERBB2 NKX2-5	7.19e-05	3	171	2	36400745
Pubmed	Genomic Alterations of NTRK, POLE, ERBB2, and Microsatellite Instability Status in Chinese Patients with Colorectal Cancer.	ERBB2 POLE	7.19e-05	3	171	2	32627883
Pubmed	The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5.	SUPT20HL1 SUPT20HL2	7.19e-05	3	171	2	24220028
Pubmed	Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling.	ZNF131 UHRF2	7.19e-05	3	171	2	22467880
Pubmed	Regeneration after blood loss and acute inflammation proceeds without contribution of primitive HSCs.	FGD5 COL1A1	7.19e-05	3	171	2	36787502
Pubmed	Mapping of five subtype genes for muscarinic acetylcholine receptor to mouse chromosomes.	CHRM2 THBS1 SCN7A	7.55e-05	17	171	3	10549128
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	SEMA4F LAMB4 RARS1 COL28A1 GRIN1 TRPM3 ZFR2 ZNF408 BOD1L1 PLCB3 PWWP3B FBN3 RAI1	7.76e-05	736	171	13	29676528
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	ZNF131 FAM193B ERBB2 TSHZ3 ZNF423 CHD8 BCL9 MAPK8IP3 ADAMTS10 RNF220 SHF CPXM1 PLCB3 PWWP3B USP54 GNAS FBN3	1.11e-04	1215	171	17	15146197
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	SNPH THSD7A CHD8 MDH2 KHSRP THBS1 PLCB3 MOG HTT COL1A1	1.31e-04	475	171	10	31040226
Pubmed	Temporal dissection of Rai1 function reveals brain-derived neurotrophic factor as a potential therapeutic target for Smith-Magenis syndrome.	RAI1 COL1A1	1.43e-04	4	171	2	34463714
Pubmed	Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis.	FGD5 DNMT3A	1.43e-04	4	171	2	36169447
Pubmed	Injury induces early activation of T-cell receptor signaling pathways in CD4+ regulatory T cells.	ZAP70 NFATC4	1.43e-04	4	171	2	20720513
Pubmed	SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts.	SHROOM3 COL1A1	1.43e-04	4	171	2	30341149
Pubmed	Immunohistochemical localisation of thrombospondin in human megakaryocytes and platelets.	THBS1 THBS3	1.43e-04	4	171	2	6338048
Pubmed	Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells.	ZAP70 MOG	1.43e-04	4	171	2	26818004
Pubmed	PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus.	PAGE1 PAGE4	1.43e-04	4	171	2	9724777
Pubmed	DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice.	POLD1 POLE	1.43e-04	4	171	2	19805137
Pubmed	Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner.	PDE2A THBS1	1.43e-04	4	171	2	16150726
Pubmed	UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131.	ZNF131 UHRF2	1.43e-04	4	171	2	23404503
Pubmed	Fibrotic response in fibroblasts from congenital disorders of glycosylation.	COMP COL1A1	1.43e-04	4	171	2	21029365
Pubmed	Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline.	THBS1 COL1A1	1.43e-04	4	171	2	18089612
Pubmed	Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication.	GRIN1 MOG	1.43e-04	4	171	2	23874151
Interaction	TOP3B interactions	SEMA4F FAM193B SEMA4B ERBB2 PDE2A SHROOM3 PLOD3 RARS1 POLE FBRSL1 GEMIN5 CHD8 BCL9 CIT MAPK8IP3 MPRIP JAG2 ARHGEF40 SETD5 ZNF408 ZNF516 DKC1 PRKN TNKS1BP1 GNAS CABIN1 ADAT1 RAI1 HTT COL1A1	5.37e-06	1470	170	30	int:TOP3B
GeneFamily	DNA polymerases	POLD1 POLE POLQ	2.53e-04	23	98	3	535
GeneFamily	Granins	SCG5 GNAS	7.97e-04	8	98	2	925
GeneFamily	Adenosine deaminases acting on RNA	ADAT3 ADAT1	7.97e-04	8	98	2	1303
Coexpression	HEVNER_CORTEX_RADIAL_GLIA_PROGENITORS	RBL1 POLD1 POLE SMOC1 TTK CIT JAM2 IFNGR1 ARHGEF40 NFATC4 DKC1 ASXL2 DNMT3A	5.30e-06	432	170	13	MM419
Coexpression	NABA_CORE_MATRISOME	LAMB4 COMP COL28A1 EMILIN2 SMOC1 SNED1 THBS1 THBS3 FBN3 COL1A1	1.34e-05	275	170	10	M5884
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A SCG5 OVOS2 THSD7B SMOC1 ADAMTS6 SCN7A ROBO1 FGD5 GRIP2 GNAS	2.21e-10	191	171	11	764c3a8829ae1253a0790744138266e81fc075ec
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A SCG5 FRMPD1 THSD7B KCNC2 SCN7A GRIP2 GNAS ATP1B1	6.24e-08	193	171	9	9f9eb241b0b82a6f12de6921c3acf6fed7cf65bb
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D122\|Adult / Lineage, Cell type, age group and donor	THSD7A ZNF423 RYR3 JAM2 JAG2 TRPM3 FGD5 GRIP2	2.93e-07	168	171	8	8c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF423 TRPM3 ADAMTS6 NFATC4 LZTS1 ROBO1 GNAS MYO18B	3.21e-07	170	171	8	cdb6fad277f284c3fd5a6f45672a8edc24715882
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF423 TRPM3 ADAMTS6 NFATC4 LZTS1 ROBO1 GNAS MYO18B	3.21e-07	170	171	8	99dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF423 TRPM3 ADAMTS6 NFATC4 LZTS1 ROBO1 GNAS MYO18B	3.21e-07	170	171	8	3a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ERBB2 PDE2A PCDHB11 DSTYK ZNF408 ROBO1 FGD5 RASAL2	4.36e-07	177	171	8	8ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FNIP2 EPS8L2 SHROOM3 THSD7A COMP CIT USP54 ATP1B1	4.55e-07	178	171	8	f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A OVOS2 THSD7B SMOC1 ADAMTS6 ROBO1 FGD5 GRIP2	4.75e-07	179	171	8	97ba67a856680f24846244c0b92c886cc0e79537
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A THSD7B SMOC1 ADAMTS6 ROBO1 FGD5 GRIP2 FBN3	5.38e-07	182	171	8	420a8fd30543e37a66ba0786215d056d308660d0
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A OVOS2 CHRM2 RYR3 ADAMTS6 ROBO1 GRIP2 FBN3	5.38e-07	182	171	8	d3a037268f026eb2f84428b1821022503cef7756
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A OVOS2 THSD7B SMOC1 ADAMTS6 SCN7A FGD5 GRIP2	6.09e-07	185	171	8	08fad1e3c3cc5f1c3eb6629a49c094b628e75a92
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A THSD7B SMOC1 ADAMTS6 ROBO1 FGD5 GRIP2 FBN3	6.09e-07	185	171	8	cefd81adb480c027545a5c78dcd05669783717f4
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A OVOS2 THSD7B SMOC1 ADAMTS6 ROBO1 FGD5 GRIP2	6.09e-07	185	171	8	bdfa8c284bbc5e85c806327fbb7778cf16242a38
ToppCell	droplet-Heart-nan-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHRM2 RBM20 ADAMTS10 ARHGEF40 SCN7A CPXM1 MYO18B COL1A1	7.45e-07	190	171	8	96a92212ea3fb35fa3d0da495e504edc61c71c23
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A THSD7B SMOC1 ADAMTS6 ROBO1 FGD5 GRIP2 FBN3	8.06e-07	192	171	8	3abee376c37c3646da33ac381aa63d50a01607a6
ToppCell	facs-Heart\|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RCSD1 JAM2 IFNGR1 ARHGEF40 SCN7A CPXM1 ITM2B COL1A1	9.78e-07	197	171	8	6a9571c0a3238b39214afdece93d7541bc8a0a70
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A ZNF423 RYR3 JAM2 SNED1 ADAMTS6 FGD5 RASAL2	1.02e-06	198	171	8	fa84bf8533d1b91d2c2bcf06b710670605072b89
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A ZNF423 RYR3 JAM2 SNED1 ADAMTS6 FGD5 RASAL2	1.02e-06	198	171	8	07701c73137947ed4a27e225975329235bbb8734
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	RIMKLA GRIA4 MINDY2 KCNC2 NGF FGD5 GRIP2	3.02e-06	161	171	7	b81b346309f3facbfbebd91cae4c5b33c7bd24ef
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNPH CARMIL2 RTN4R GRIN1 CIT CHRM2 KCNC2	3.55e-06	165	171	7	6d8b5669eee9b0903c9260fea707d186c9d7fefa
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNPH CARMIL2 RTN4R GRIN1 CIT CHRM2 KCNC2	3.55e-06	165	171	7	02cd87dfa2ca40e13455a4b9308477e82f76289b
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D231\|Adult / Lineage, Cell type, age group and donor	SNPH THSD7A ZNF423 JAM2 ADAMTS6 FGD5 GRIP2	4.00e-06	168	171	7	aca34c51758c65925ad24110294a72b2dea6db72
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TSHZ3 SMOC1 ICAM5 SCN7A CPXM1 SPINDOC COL1A1	4.00e-06	168	171	7	d2b91f2adc95dcfa623f8d7ca2df1c6f884da988
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAP10 SCARF1 JAG2 SCN7A YDJC POLQ ADGRL2	4.16e-06	169	171	7	8a6d05b5d60b2b2e43a8ff7521feb79cd6dbd940
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SNPH THSD7A SMOC1 JAM2 SCARF1 ICAM5 PWWP3B	4.67e-06	172	171	7	9a1743abcd5fbd38253ea84d88ad716cfb71de36
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A OVOS2 THSD7B ADAMTS6 ROBO1 GRIP2 FBN3	5.04e-06	174	171	7	fdadac1eaab2c4a67e4832f0901df22e893add6a
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A OVOS2 THSD7B SMOC1 ADAMTS6 FGD5 GRIP2	6.77e-06	182	171	7	7dc61e901428cea04f00ebb0939a44d21a6145c6
ToppCell	tumor_Lymph_Node_/_Brain-Endothelial_cells\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	LAMB4 PDE2A JAM2 SCARF1 FGD5 GRIP2 ADGRL2	6.77e-06	182	171	7	d7cce5dd7046f06bf40f00c9dbfa610722b03333
ToppCell	Hippocampus-Neuronal-Inhibitory\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TCERG1L GRIA4 CIT KCNC2 NGF GRIP2 GNAS	6.77e-06	182	171	7	b54ae650c04dfd0759c5f5e752b9bf684dd36516
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A OVOS2 THSD7B ADAMTS6 SCN7A FGD5 GRIP2	7.53e-06	185	171	7	16e9ccea0e3b95d90dc48ef74206c805681dac0b
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A CHRM2 RYR3 ADAMTS6 ROBO1 GRIP2 FBN3	7.53e-06	185	171	7	0b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sncg-Sncg_Vip_Nptx2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	THSD7A SMOC1 JAM2 NGF ROBO1 PWWP3B	7.75e-06	122	171	6	1720756e0b3e8db14a9ccabe83f9b41689a4f754
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Sncg-Sncg_Vip_Nptx2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	THSD7A SMOC1 JAM2 TRPM3 ROBO1 PWWP3B	7.75e-06	122	171	6	91e338db581b36baffecc323b1909f2069b27242
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC30A8 ADAMTS10 THBS1 ARHGEF40 SCN7A CPXM1 COL1A1	7.80e-06	186	171	7	35c88cc4eb388811fcac4323b549e5897fa8dc27
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC30A8 ADAMTS10 THBS1 ARHGEF40 SCN7A CPXM1 COL1A1	7.80e-06	186	171	7	d998c5b00083cf2a7cd5341a98b7374b4de73c63
ToppCell	ILEUM-inflamed-(8)_Fibroblast-(8)_Smooth_muscle_cells\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	LAMB4 TSHZ3 SLC30A8 IGHA1 ADAMTS6 SCN7A FGD5	7.80e-06	186	171	7	cacc2f0b2ed46516173b61ba1c5c226a2db7cddc
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A THSD7B SMOC1 ADAMTS6 ROBO1 FGD5 GRIP2	8.08e-06	187	171	7	ae2ee6f8e5c37cb88a67f3e742cf86e57657bfaf
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF423 BTBD18 JAM2 SCARF1 TNKS1BP1 ADGRL2 RASAL2	8.08e-06	187	171	7	3548a9914c2b2f5d805798ce22ab26eab6d03897
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	EPS8L2 SHROOM3 OVCH2 PLEKHG4B ICAM5 USP54 FBN3	8.08e-06	187	171	7	4ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Endothelial-endothelial_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF423 BTBD18 JAM2 SCARF1 TNKS1BP1 ADGRL2 RASAL2	8.08e-06	187	171	7	f4de4b7af1fdfbd628b1f509c060c1079d2e5437
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Endothelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF423 BTBD18 JAM2 SCARF1 TNKS1BP1 ADGRL2 RASAL2	8.08e-06	187	171	7	81754e965848b718be20ee97ce072ce426938a69
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSHZ3 THSD7A BTBD18 THSD7B JAM2 JAG2 FGD5	8.08e-06	187	171	7	e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCell	tumor_Lymph_Node_/_Brain-Endothelial_cells-Tumor_ECs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	LAMB4 PDE2A JAM2 SCARF1 FGD5 GRIP2 ADGRL2	8.08e-06	187	171	7	be5f8c5802b0fa8cc1e274fdf06b13eb8ceb8ad4
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A THSD7B SMOC1 ADAMTS6 ROBO1 FGD5 FBN3	8.36e-06	188	171	7	6ee3f8f94ea7bdf652c9575fc65bff08070093a4
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6\|TCGA-Breast / Sample_Type by Project: Shred V9	ZNF423 THSD7B SCARF1 ADAMTS10 ARHGEF40 SCN7A CPXM1	8.36e-06	188	171	7	c90669b51e1902fe7726555290c91c92a911df83
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A THSD7B SMOC1 ADAMTS6 ROBO1 FGD5 FBN3	8.36e-06	188	171	7	c66fccdfe68760b8c3efca77e3c25966dc9a8a5f
ToppCell	cellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	POLD1 ZNF175 ZNF423 JAG2 MLKL ADAMTS6 ADAT1	8.66e-06	189	171	7	bccb3481ffed597c845fe860da658505316105b5
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	CHRM2 RBM20 PPARGC1B PRKN GRIP2 MYO18B ADGRL2	8.66e-06	189	171	7	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	COVID-19-Heart-CM_4\|Heart / Disease (COVID-19 only), tissue and cell type	FNIP2 SEMA4B SHROOM3 THBS1 FAM153A MYO18B ATP1B1	8.96e-06	190	171	7	3729648a17093b438398b82e32bbccc3af7b8c5d
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GRIA4 THSD7B SMOC1 THBS3 NGF CPXM1 COL1A1	9.27e-06	191	171	7	b51e0f5d1b93f526160c904e9091313a5364f3a7
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GRIA4 CHRM2 JAM2 NRK SCN7A ATP1B1 COL1A1	9.59e-06	192	171	7	20ede290e01ad574afd122d72b59dbc52c595fad
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A FRMPD1 THSD7B KCNC2 ADAMTS6 NGF GRIP2	9.59e-06	192	171	7	bf1943715085c4124b1675888b0615c9500ec888
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A SMOC1 CIT ADAMTS6 FGD5 GNAS FBN3	9.59e-06	192	171	7	025fac36b862f9ca7f96fb4a1946c44ba7cbc382
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A SMOC1 ADAMTS6 ROBO1 FGD5 GRIP2 FBN3	9.59e-06	192	171	7	6a252e298f8a454623fa9c1c893a7a45a886d694
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD7A RYR3 JAM2 JAG2 SNED1 ADAMTS6 FGD5	9.92e-06	193	171	7	2e72309607902dabe3218888b22a77fe941f3570
ToppCell	Mesenchymal_cells-Stromal_fibro.\|World / Lineage and Cell class	COL28A1 JAM2 THBS1 THBS3 SCN7A CPXM1 COL1A1	1.06e-05	195	171	7	69723b06c2a5c2aaf4d10874b11bca7f06822bdc
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF423 RYR3 JAM2 JAG2 SNED1 ADAMTS6 FGD5	1.06e-05	195	171	7	77e47d2e8b3eb7f7c9620369ccaf87581f923bdb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A SNED1 NXF3 FGD5 GRIP2 ADGRL2 RASAL2	1.06e-05	195	171	7	23ced69fd904f1d4114b1a7f99f4b5f65ea8824b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A ZNF423 RYR3 JAM2 SNED1 ADAMTS6 FGD5	1.10e-05	196	171	7	8ad8efb631164b46f0c082572270188e5ead20bf
ToppCell	background-Endothelial_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	PDE2A THSD7A THSD7B SNED1 FGD5 ADGRL2 RASAL2	1.10e-05	196	171	7	e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A ZNF423 RYR3 JAM2 SNED1 ADAMTS6 FGD5	1.10e-05	196	171	7	9606ea7e42f707e69ea891b3521037613b9675f5
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A ZNF423 RYR3 SNED1 ROBO1 FGD5 RASAL2	1.13e-05	197	171	7	cd509e49bbdbf991cc5913960ff3ef275ad40628
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A ZNF423 RYR3 SNED1 ROBO1 FGD5 RASAL2	1.13e-05	197	171	7	412cb5f37df57121ddd1492021445479c7cbccbf
ToppCell	Parenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ZNF423 NACAD JAM2 SCML2 ADAMTS6 ZNF408 FGD5	1.17e-05	198	171	7	88b4662be9cc933a402c52673fa5e00fa979c0db
ToppCell	Biopsy_Control_(H.)-Mesenchymal-Mesothelial_cells\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	SCG5 TRPM3 NRK NGF CPXM1 PWWP3B COL1A1	1.21e-05	199	171	7	ca970114b5aef4518ce580897a62ac88688b2671
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	THSD7A SMOC1 ADAMTS6 ROBO1 FGD5 GRIP2 FBN3	1.25e-05	200	171	7	7e51715525fdb001b7042b2bfcb9de81ecb5e4ee
ToppCell	Biopsy_Control_(H.)-Mesenchymal-PLIN2+_Fibroblasts\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	SCG5 GRIA4 NFATC4 NGF CPXM1 PWWP3B COL1A1	1.25e-05	200	171	7	cdaf462b1db29dab61038eeab5ddd3eef3386763
ToppCell	Neuronal-Inhibitory\|Neuronal / cells hierarchy compared to all cells using T-Statistic	THSD7A FRMPD1 THSD7B KCNC2 ADAMTS6 NGF GRIP2	1.25e-05	200	171	7	9ff8647e2de0b538e15929dca88ebb20ff7ab043
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	THSD7A CHRM2 RYR3 ADAMTS6 ROBO1 GRIP2 FBN3	1.25e-05	200	171	7	501a3b93624df463458a35d3e6648d4ccc941724
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2-L1-3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	THSD7A CHRM2 RYR3 ADAMTS6 ROBO1 GRIP2 FBN3	1.25e-05	200	171	7	d1f36a8232411933b1494168ec912fd0e5246428
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Endothelial-1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	PDE2A THSD7A JAM2 JAG2 ADAMTS6 FGD5 ADGRL2	1.25e-05	200	171	7	27507c4b41d45c7cc50e4993169c0302be22ee34
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	COL28A1 SNED1 NRK SCN7A PWWP3B USP54 COL1A1	1.25e-05	200	171	7	29054cf55e88e1ac81a562d8dd9af9b7c749321d
ToppCell	Parenchyma_COVID-19-Endothelial-TX-Endothelial-1\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	PDE2A THSD7A JAM2 JAG2 ADAMTS6 FGD5 ADGRL2	1.25e-05	200	171	7	b65fb8d378abd91cdabf5faac5f4b90d527f8c44
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Endothelial-1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PDE2A THSD7A JAM2 JAG2 ADAMTS6 FGD5 ADGRL2	1.25e-05	200	171	7	2cb6e35add34b9dc564ebcf5d3cbc761325ca9f4
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	THSD7A SMOC1 ADAMTS6 ROBO1 FGD5 GRIP2 FBN3	1.25e-05	200	171	7	75649534a98bc738fca62d071de0978dc61eb24f
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TCERG1L SMOC1 CIT RYR3 THBS3 SCN7A	2.07e-05	145	171	6	590ba937c741ae67460f303eca88b1cd3ac87f64
ToppCell	(6)_Endothelial_cells-(6)_Endothelial-C_(Capillary_Aerocyte_)\|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	SHROOM3 RCSD1 CHRM2 IFNGR1 ADGRL2 ITM2B	3.24e-05	157	171	6	84f629b7f589ca8a1abc220fa740c4a6fdc1b579
ToppCell	TCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue-Urothelial_normal_tissue\|TCGA-Bladder / Sample_Type by Project: Shred V9	PDE2A CHRM2 RYR3 JAM2 SCN7A PRKN	3.61e-05	160	171	6	8a41e2c96e0e170ac35daf6c403bf961b8d7c30b
ToppCell	TCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue\|TCGA-Bladder / Sample_Type by Project: Shred V9	PDE2A CHRM2 RYR3 JAM2 SCN7A PRKN	3.61e-05	160	171	6	c8dc575562b463fd30832d322c28006f18f7ab9c
ToppCell	TCGA-Bladder-Solid_Tissue_Normal\|TCGA-Bladder / Sample_Type by Project: Shred V9	PDE2A CHRM2 RYR3 JAM2 SCN7A PRKN	3.61e-05	160	171	6	d6678996e12eaf2b735f1dfae32418cb2fabf268
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SCG5 ZAP70 ADAMTS10 CPXM1 POLQ COL1A1	3.74e-05	161	171	6	a7e09cf2ca6cd70d40d08440fe9c5ab9befa1b79
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SCG5 ZAP70 ADAMTS10 CPXM1 POLQ COL1A1	3.74e-05	161	171	6	08920a716f6ec62538e361211455a30ad726d7be
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EMILIN2 RYR3 JAM2 NRK SCN7A ATP1B1	4.14e-05	164	171	6	d167c7a987b9b35d1e7725c803df4f9cd5380e47
ToppCell	367C-Myeloid-Dendritic-cDC_proliferating_2\|367C / Donor, Lineage, Cell class and subclass (all cells)	SNPH RNASEH2A POLD1 PPARGC1B PPIP5K1 POLQ	4.14e-05	164	171	6	0662cd9d21608efacc336e0a582859f3b9a4951d
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ERBB2 COMP SCG5 SCARF1 FAM153A SPINDOC	4.14e-05	164	171	6	d2218d50e0e2d19f919dcb460b3840687c082810
ToppCell	LPS-antiTNF-Endothelial-Mes-Like-Alv_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SNPH ADAT3 RNASEH2A ZNF423 RCSD1 JAM2	4.43e-05	166	171	6	94a00edf66d54bc5f7343daea700ca26cf38fd90
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	THSD7A ZNF423 SNED1 NFATC4 SCN7A ADGRL2	4.43e-05	166	171	6	f416d8a322f086c769659a9fab6b460a2d546ab1
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SCG5 ARHGEF40 SHF SKOR1 CPXM1 COL1A1	4.58e-05	167	171	6	31cf8bf2eb523f6e7e319620648ff37fc09e2601
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SCG5 ARHGEF40 SHF SKOR1 CPXM1 COL1A1	4.58e-05	167	171	6	805129f887078340b260aa136b0ba19f2bd6ea03
ToppCell	5'-Airway_Nasal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SCG5 ARHGEF40 SHF SKOR1 CPXM1 COL1A1	4.58e-05	167	171	6	3acb18428d1d33ad430c2fd031b1a91baee3c01d
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D231\|Adult / Lineage, Cell type, age group and donor	FNIP2 SHROOM3 SLC30A8 CIT PWWP3B ATP1B1	5.06e-05	170	171	6	269dee5abca9f6aa079f116f0d8f1d198604d9d4
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	EPS8L2 SHROOM3 THSD7A CIT USP54 ATP1B1	5.06e-05	170	171	6	a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SHROOM3 RCSD1 CHRM2 NFATC4 ADGRL2 ITM2B	5.06e-05	170	171	6	f0b0d2d0402de3ed7322284a599646db43475761
ToppCell	368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SHROOM3 RCSD1 CHRM2 NFATC4 ADGRL2 ITM2B	5.06e-05	170	171	6	054360a3b05f5e41221c98b122d241b1affad26a
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_ACHE\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A RYR3 ADAMTS6 FGD5 GRIP2 FBN3	5.06e-05	170	171	6	36dbbdb13f69307afd2122ff051b2980850c1f00
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD7A THSD7B SMOC1 ADAMTS6 FGD5 FBN3	5.94e-05	175	171	6	e78bf0c33a741bb97e987e41ac33da9e623a08ec
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RCSD1 THSD7B LZTS1 NGF GRIP2 COL1A1	6.33e-05	177	171	6	4943d040eee0f9dceaddc7498171281d170e271f
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	POLE MAP10 SCML2 TRPM3 NRK COL1A1	6.33e-05	177	171	6	3e149bff1f1b393a7abe98984e37981c8296f95d
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TCERG1L GRIN1 THSD7B PPARGC1B PRKN POLQ	6.33e-05	177	171	6	8abdf1d970b2f15e17e185f3e612dd5065c88757
Disease	Intellectual Disability	RARS1 RNASEH2A KDM5C CHD8 GRIN1 MAPK8IP3 POLR3B TRPM3 GNAS RAI1 HTT DNMT3A	1.06e-05	447	168	12	C3714756
Disease	Malignant neoplasm of breast	ERBB2 PDE2A ADAT3 FRMPD1 EPG5 JAG2 PPARGC1B THBS1 TRMT10A THBS3 HOXB9 ICAM5 ROBO1 BOD1L1 FGD5 DLEC1 USP54 RASAL2 DNMT3A	1.27e-05	1074	168	19	C0006142
Disease	Profound Mental Retardation	KDM5C CHD8 POLR3B GNAS RAI1 DNMT3A	1.50e-04	139	168	6	C0020796
Disease	Mental Retardation, Psychosocial	KDM5C CHD8 POLR3B GNAS RAI1 DNMT3A	1.50e-04	139	168	6	C0025363
Disease	Mental deficiency	KDM5C CHD8 POLR3B GNAS RAI1 DNMT3A	1.50e-04	139	168	6	C0917816
Disease	cortical thickness	FNIP2 SHROOM3 ZNF423 TM7SF3 PCDHB11 MINDY2 ETV3L MAPK8IP3 JAG2 THBS1 THBS3 ARHGEF40 SHF SETD5 ROBO1 DLEC1	6.51e-04	1113	168	16	EFO_0004840
Disease	Ovarian neoplasm	ERBB2 PRKN	6.64e-04	7	168	2	cv:C0919267
Disease	pyridoxate measurement	SHROOM3 EMILIN2 THSD7B	7.25e-04	31	168	3	EFO_0010527
Disease	cocaine use disorder, social environment measurement	TRAK2 ADGRL2	8.82e-04	8	168	2	EFO_0010445, EFO_0010552
Disease	lung cancer (implicated_via_orthology)	POLE ROBO1	1.13e-03	9	168	2	DOID:1324 (implicated_via_orthology)
Disease	Facies	CHD8 DNMT3A	1.41e-03	10	168	2	C0282631
Disease	Autism Spectrum Disorders	TSHZ3 CHD8 RAI1 DNMT3A	1.43e-03	85	168	4	C1510586
Disease	Childhood Medulloblastoma	ERBB2 SCG5 SCML2	1.89e-03	43	168	3	C0278510
Disease	Melanotic medulloblastoma	ERBB2 SCG5 SCML2	1.89e-03	43	168	3	C1275668
Disease	Medullomyoblastoma	ERBB2 SCG5 SCML2	1.89e-03	43	168	3	C0205833
Disease	Desmoplastic Medulloblastoma	ERBB2 SCG5 SCML2	1.89e-03	43	168	3	C0751291
Disease	Adult Medulloblastoma	ERBB2 SCG5 SCML2	1.89e-03	43	168	3	C0278876
Disease	hematocrit	SHROOM3 RNMT FBRSL1 MPRIP THBS3 ARHGEF40 YDJC PLCB3 FGD5 ASXL2 UHRF2 ITM2B RAI1 DNMT3A	2.00e-03	1011	168	14	EFO_0004348
Disease	Neurobehavioral Manifestations	NGF RAI1	2.05e-03	12	168	2	C0525041
Disease	Adenocarcinoma of large intestine	ERBB2 POLE NRK NEK11	2.24e-03	96	168	4	C1319315
Disease	sphingomyelin 18:1 measurement	LZTS1 TNKS1BP1	2.41e-03	13	168	2	EFO_0010394
Disease	opioid dependence	KCNC2 DLEC1 MYO18B ADGRL2 SPINDOC COL1A1	2.44e-03	237	168	6	EFO_0005611
Disease	major depressive episode	THSD7A PRKN ADGRL2	2.45e-03	47	168	3	EFO_0007634
Disease	intraocular pressure measurement	THSD7A SLC30A8 MAPK8IP3 ADAMTS6 ZNF516 CPXM1 BOD1L1 DLEC1 ATP1B1	2.66e-03	509	168	9	EFO_0004695
Disease	Neoplasm of lung	ERBB2 PRKN	2.80e-03	14	168	2	cv:C0024121
Disease	Manganese Poisoning	PRKN HTT	2.80e-03	14	168	2	C0677050
Disease	Lung cancer	ERBB2 PRKN	2.80e-03	14	168	2	cv:C0242379
Disease	LUNG CANCER	ERBB2 PRKN	2.80e-03	14	168	2	211980
Disease	Medulloblastoma	ERBB2 SCG5 SCML2	2.92e-03	50	168	3	C0025149
Disease	Tourette syndrome	EFL1 THSD7A POLR3B	2.92e-03	50	168	3	EFO_0004895
Disease	glycerate measurement	THSD7B RYR3	3.22e-03	15	168	2	EFO_0021029
Disease	Mammary Carcinoma, Human	ERBB2 PDE2A JAG2 PPARGC1B THBS1 HOXB9 ICAM5 FGD5 DNMT3A	3.26e-03	525	168	9	C4704874
Disease	Mammary Neoplasms, Human	ERBB2 PDE2A JAG2 PPARGC1B THBS1 HOXB9 ICAM5 FGD5 DNMT3A	3.26e-03	525	168	9	C1257931
Disease	Mammary Neoplasms	ERBB2 PDE2A JAG2 PPARGC1B THBS1 HOXB9 ICAM5 FGD5 DNMT3A	3.35e-03	527	168	9	C1458155
Disease	Familial thoracic aortic aneurysm and aortic dissection	PLOD3 ADAMTS10 COL1A1	3.45e-03	53	168	3	C4707243
Disease	central nervous system disease (implicated_via_orthology)	GEMIN5 GRIA4	3.67e-03	16	168	2	DOID:331 (implicated_via_orthology)
Disease	Breast Carcinoma	ERBB2 PDE2A JAG2 PPARGC1B THBS1 HOXB9 ICAM5 FGD5 DNMT3A	3.83e-03	538	168	9	C0678222
Disease	Benign neoplasm of stomach	ERBB2 POLE	4.14e-03	17	168	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	ERBB2 POLE	4.14e-03	17	168	2	C0496905
Disease	Antibody Deficiency Syndrome	ZAP70 EPG5	4.14e-03	17	168	2	C0003257
Disease	Carcinoma in situ of stomach	ERBB2 POLE	4.14e-03	17	168	2	C0154060
Disease	urate measurement, spine bone mineral density	FAM193B RBM20 ROBO1	4.45e-03	58	168	3	EFO_0004531, EFO_0007701
Disease	FEV change measurement, response to bronchodilator	RNASEH2A MLYCD ADGRL2	4.45e-03	58	168	3	EFO_0005921, GO_0097366
Disease	caudal middle frontal gyrus volume measurement	ZFAT KHSRP	4.64e-03	18	168	2	EFO_0010290
Disease	Colorectal Neoplasms	TCERG1L SCG5 POLD1 POLE ICAM5 FHL3	5.22e-03	277	168	6	C0009404
Disease	serum urea measurement	SHROOM3 EPG5 THBS3 GNAS ADGRL2	5.28e-03	195	168	5	EFO_0009795
Disease	alcohol use disorder (implicated_via_orthology)	ERBB2 EPS8L2 KDM5C FBRSL1 RYR3	5.28e-03	195	168	5	DOID:1574 (implicated_via_orthology)
Disease	neuropsychological test	TSHZ3 THSD7B JAM2 POLR3B GRIP2	5.51e-03	197	168	5	EFO_0003926
Disease	atrial fibrillation	ZFAT POLD1 FBRSL1 RBM20 MPRIP NKX2-5 MYO18B	5.53e-03	371	168	7	EFO_0000275
Disease	abdominal fat cell number	COL28A1 FRMPD1 MINDY2 CHRM2 SCN7A	5.63e-03	198	168	5	EFO_0021534

Protein segments in the cluster

Peptide	Gene	Start	Entry
GLVEQPKCLEAGSPE	ADAT3	6	Q96EY9
PDTSPRGCNIKGEDE	ESD	81	P10768
DLDDKGCPAEQRASP	ERBB2	636	P04626
GCPLSGTPEEKVEAD	PABPN1L	131	A6NDY0
LTCNTEPPKEGGEAR	EPG5	96	Q9HCE0
SPGQDLEPACDGARK	FBRSL1	141	Q9HCM7
CGDVPSEPKERGDFN	ATP1B1	126	P05026
DPALCFLEKAGRPDD	CHD8	1651	Q9HCK8
AGEKEPQLSEACGPT	ARHGEF40	451	Q8TER5
GDLEKRSEPQPEEGS	DNMT3A	91	Q9Y6K1
EDPCLGPRNEDGQLR	CARMIL2	1336	Q6F5E8
VCLPAGGAGEQEKEP	C2orf27A	156	P0DPF5
SPEECKGQGEPLDDR	ASB10	6	Q8WXI3
ADGDGVPNEKDNCPL	COMP	316	P49747
QDGSAIETCPKGEEP	EFL1	466	Q7Z2Z2
IETCPKGEEPRGDEQ	EFL1	471	Q7Z2Z2
EAENRCGSPREEKPA	RCSD1	291	Q6JBY9
CGSPREEKPAGEEAE	RCSD1	296	Q6JBY9
PAGTLDPAEKQETGC	CPXM1	101	Q96SM3
PINKEGCIPEGDVRE	ADGRL2	1436	O95490
PVGKTADDGCLENTP	SCG5	121	P05408
PRDPVTENCVQGEEK	CHRM2	266	P08172
KTRDDEPVCGRPLGI	APMAP	141	Q9HDC9
TGKPLDIDECGEIPA	FBN3	1716	Q75N90
GQRPVEEFELCLPDG	CIT	1486	O14578
PGRKEECESQGEVQP	ASXL2	441	Q76L83
TPGDGPEECKDVNKV	ADAMTS10	1061	Q9H324
LDSGRGTCLDNEPPK	ADAMTS6	456	Q9UKP5
NLEAPGNERKCEDPD	ADAT1	176	Q9BUB4
GNERKCEDPDSPVTK	ADAT1	181	Q9BUB4
GTEDLKGPGQRCENE	R3HCC1	191	Q9Y3T6
ECSKEAPAEPGGEAQ	RAI1	1806	Q7Z5J4
PFVDDCKTRGTPEDG	RBM20	1061	Q5T481
TPEDGACEGSPLEEK	RBM20	1071	Q5T481
GLSSPREKNEPDGCA	RIMKLA	316	Q8IXN7
KLRVSCEAPGDGDPF	GON7	16	Q9BXV9
LVQPKTGCELGDGPD	PAGE1	66	O75459
PKTGCERGDGPDVQE	PAGE1	111	O75459
PAILGEPKGSCQEEA	CAPN15	91	O75808
EPKGSCQEEAGPVRT	CAPN15	96	O75808
GLNLDDGKEDPCIPQ	OVOS1	566	Q6IE37
TPPIEERKVEGDCQE	PAGE4	51	O60829
RALEGEGIVEQPCPD	PLOD3	551	O60568
KGIEPGEKCADRSPV	NXF3	271	Q9H4D5
EPPGDCLTTAGDKLQ	KCNC2	41	Q96PR1
DSQLAECRGPPEVEG	LRRC55	221	Q6ZSA7
ETCPRPTEKQEAELG	MPRIP	506	Q6WCQ1
EKEQGEASSPRGLCP	MAP10	41	Q9P2G4
RCRDELEGPEPKGGN	LZTS1	301	Q9Y250
DPLTCDREGDGEPKS	MAPK8IP3	736	Q9UPT6
DPNPVDSGCRGIDSK	NGF	181	P01138
VDCKDPDDVVPVGQR	ITM2B	36	Q9Y287
ERCGQLDGDPKEVSP	MTMR6	381	Q9Y217
DNSTPEPKENGEEGC	GPBP1L1	351	Q9HC44
CTRENDPIQGPDGKV	SPINK5	381	Q9NQ38
CTRENDPVRGPDGKT	SPINK5	646	Q9NQ38
APGFAGPDCRINIDE	JAG2	816	Q9Y219
LGPEQLPDCLKGCDV	MDH2	81	P40926
LREKTPAPAEGQCAD	MLYCD	56	O95822
SVGENGRVLTPDCPK	GRIA4	866	P48058
GRLFSCEVDGKPQPS	ICAM5	591	Q9UMF0
EVPDLDGTRAPINGC	PDE2A	921	O00408
CVDRGLDEGPRSIPK	FGD5	41	Q6ZNL6
VPQCERDEGSLGKPL	FAM153A	41	Q9UHL3
EEKEEQPEGRLSCSP	NEK11	401	Q8NG66
ECLDLGRGEPVSVKP	RASAL2	101	Q9UJF2
RPDLGGKEADDNCLV	POLE	1691	Q07864
VELRCQDKEGNPAPE	JAM2	151	P57087
GEAGVPEKRPCEDLR	PIK3IP1	86	Q96FE7
NLDDGKEDPCIPQRD	OVOS2	616	Q6IE36
VKRQQEPLGEDCPSE	MLKL	426	Q8NB16
PVLVRDGKPCLGDSA	NKX2-5	221	P52952
PENGEPVGTREIKCC	DSTYK	446	Q6XUX3
VPCNILGEARPEDAG	EPS8L2	541	Q9H6S3
GDEVELPCRISPGKN	MOG	46	Q16653
EKRPLAPEEEEDAGC	FAM131B	276	Q86XD5
GDNGRIVCSIPEDLP	PCDHB11	376	Q9Y5F2
CEGSEDKERPDQTNP	HOXB9	161	P17482
CPGLSNGEEVGLEKP	PLCB3	516	Q01970
EKNGEILAPPESLCG	BOD1L1	2681	Q8NFC6
ELEKEPAGENRGPTE	BTBD18	556	B2RXH4
KGPDCNKTPGSEREL	CCDC82	71	Q8N4S0
GCEQPLGSRSFVPDK	FHL3	131	Q13643
DEATEPGDQENKPCR	HTT	651	P42858
PGDQENKPCRIKGDI	HTT	656	P42858
GAEPTCSQEGKLRPE	CABIN1	2061	Q9Y6J0
GAEDPRCLEALKPGN	COL28A1	1066	Q2UY09
QLPQPCEADEGLGEE	FAM193B	376	Q96PV7
EPRSDECGINPGEKI	FRMPD1	1081	Q5SYB0
CPEGTDSRDLGLKPD	FNIP2	601	Q9P278
RDPGTPNDDSDIKEC	BCL9	111	O00512
QEIPIRDDGFPIKGC	POLQ	1881	O75417
SGKSAVQGPPERDLC	IGHA1	166	P01876
PEIVPEEKDCGDAEG	RNMT	86	O43148
NRAGTQKPICDPDTG	LAMB4	1131	A4D0S4
PRGLADKQGPEECDA	CXorf38	121	Q8TB03
GDCQEGPKDPVKTLR	EMILIN2	116	Q9BXX0
KGGLDPREVFCPETR	ETV3L	321	Q6ZN32
EPDSPAERCGLLQVG	GRIP2	491	Q9C0E4
DHRAPGPGQKQECEE	DLEC1	1536	Q9Y238
PLACGSNPLKREIGD	DKC1	71	O60832
PKVDIPRDSGCFEGS	SASH3	341	O75995
DIECAGRKGIFPEPE	POLD1	316	P28340
SEEFAVCRDGKIGPP	IFNGR1	116	P15260
ENCSETDGPGLKRPA	NRK	1081	Q7Z2Y5
CKVQISPDSGGLPER	KHSRP	176	Q92945
LPGAVPLCKEEEGEE	MINDY2	211	Q8NBR6
TGRATDEEPLGLPKC	RTN4R	321	Q9BZR6
PDNECIEKVEIAGPG	RARS1	146	P54136
PAKESGLGAEERCPS	SKOR1	541	P84550
EECGKEPEDPQELRS	SUPT20HL1	46	Q3ZLR7
ERLESGRGKCPFEPA	SEMA4F	161	O95754
LLPEPDQRKVTCEGG	PRKN	341	O60260
QPADEGRSCPNAVEK	THSD7A	1196	Q9UPZ6
KEPCVLGVDEAGRGP	RNASEH2A	26	O75792
EPASCNGKLPLGAEE	NFATC4	346	Q14934
KDEGDLPGCLEEREN	PWWP3B	136	Q5H9M0
PDCSSGPVKEERGDL	RBL1	916	P28749
EDRPIGKFCGESLPS	OVCH2	376	Q7RTZ1
VENDGEACGPPEVSR	GNAS	61	Q5JWF2
CKQPVHRGPGDEDQE	RNF167	271	Q9H6Y7
VLLEDGKGRCPFDPN	SEMA4B	176	Q9NPR2
GREEDRSCDAGAPPK	PPARGC1B	736	Q86YN6
SVEEGPECQGPVVDR	POLR1H	71	Q9P1U0
DLNGLPSPVEERCGD	SETD5	66	Q9C0A6
GRPTCAVNTKAEDPG	SHROOM3	691	Q8TF72
PLEAGSDGCEEPKQQ	SPINDOC	56	Q9BUA3
GGIFPEDEIPEKACR	RRP1	336	P56182
PCTGEEPGEAKEREA	RNF220	416	Q5VTB9
TKLSDPAVCGDRQPG	SNPH	216	O15079
GCGSPEQDPQKQAEE	SCARF1	796	Q14162
RCQAEVDCGPPEEVK	SNED1	691	Q8TER0
EECGKEPEDPQELRS	SUPT20HL2	46	P0C7V6
PKCPLQGASRADVGD	CHPF2	391	Q9P2E5
DETKNCPGAEVPEGE	COL1A1	76	P02452
TEGCGSPKPEEAKRE	TCERG1L	421	Q5VWI1
RNDPECDLCGGDPEK	UHRF2	326	Q96PU4
GRCQEAEIGPQKPDS	TRAK2	856	O60296
ESLGKPECEEFLPRG	UBA6	426	A0AVT1
SGEACVENGKPELSP	ZNF516	231	Q92618
TEADDPFKDRELPGC	SMOC1	301	Q9H4F8
QFEGPEKSCLSPGRE	SHF	266	Q7M4L6
DPQGPELGEACEKGN	ZNF35	146	P13682
QCPRERPEELESGGM	SLC30A8	36	Q8IWU4
SGLEPQPGVFDCLRD	ZAP70	106	P43403
DGIPDDKDNCRLVPN	THBS1	901	P07996
CPGDTQLEEGRKEPE	ZFAT	536	Q9P243
LLTDGPGLQDPCERD	ZFR2	846	Q9UPR6
VPEASGPQNDGKELC	SSX2	126	Q16385
DSPDIQPVGTCEKEG	SCML2	111	Q9UQR0
SNEDEDLGPCEGPSK	SPANXN3	96	Q5MJ09
PGCRPDVELGADDQA	RYR3	1106	Q15413
PVEGPGCTKEEDVLA	PLEKHG4B	126	Q96PX9
IDPPCGQNETREDGK	TRPM3	1086	Q9HCF6
VGCDPQDDPDITGKS	TRIM51	311	Q9BSJ1
PLGPLLQDGDVDEEC	ZNF408	251	Q9H9D4
SQEGPVKSPAECREE	TNKS1BP1	221	Q9C0C2
EGEEQAREPELPCGL	GEMIN5	781	Q8TEQ6
LGTKPEPEEGENECR	ZNF609	226	O15014
RDQNIPGCESLGLDP	TTMP	196	Q5BVD1
LDDLDSKRPGEEVPC	YDJC	296	A8MPS7
IPERLCESKEGGQGE	ZNF627	66	Q7L945
PSDTPEGEACGLVKN	POLR3B	481	Q9NW08
KGEPATLNCKAEGRP	ROBO1	81	Q9Y6N7
VDGDGIPNGLDNCPK	THBS3	566	P49746
DGCKDGSPLAEPVEN	TSHZ3	676	Q63HK5
VDDAGCPDLGKEPLV	MYO18B	2391	Q8IUG5
REGDEDPCPSALGAK	ZDHHC11	341	Q9H8X9
CRDLVVPGSKPSGND	TTK	306	P33981
CDPDKINPGTQVRGD	SCN7A	1451	Q01118
KIRQPAACPGGEEVD	GTF3C2	226	Q8WUA4
EESQKPRLGEGCEPI	TRMT10A	26	Q8TBZ6
RKGQIKEDGCPSDPT	ZNF131	226	P52739
GGLEGEPECDQKTSR	ZNF423	26	Q2M1K9
GEGRPCPTELTQEKT	THSD7B	1281	Q9C0I4
ENLCPGKASDEPDRA	PPIP5K1	946	Q6PFW1
PEDDGCLLKQEPRGR	nan	146	Q8N7P7
RDPEDDGCLLKQGPR	nan	246	Q8N7P7
NPEDDGCLLKQGPRG	nan	281	Q8N7P7
NRDPEDDGCLLKQEP	nan	426	Q8N7P7
PQVLGPEKQDGSCEA	ZNF175	11	Q9Y473
ERDPVPGGCNLEFDL	TM7SF3	131	Q9NS93
PLDAPEGKLQGSRCD	USP54	991	Q70EL1
ECPPTVVVKEELGGD	KDM5C	266	P41229
TLCPDSPQNLKEEGG	NACAD	556	O15069
LEKENITDPPRGCVG	GRIN1	296	Q05586