Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN2A SCN3A CAPN3

1.27e-0714694GO:0031402
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN1A SCN2A SCN3A SCN10A

1.84e-0626694GO:0005248
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN2A SCN3A CAPN3

1.84e-0626694GO:0031420
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

SCN1A SCN2A SCN10A

2.59e-0517693GO:0099508
GeneOntologyMolecularFunctionsodium channel activity

SCN1A SCN2A SCN3A SCN10A

3.12e-0552694GO:0005272
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

TRPA1 SCN1A SCN2A SCN10A CACHD1

4.17e-04182695GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

TRPA1 SCN1A SCN2A SCN10A CACHD1

4.39e-04184695GO:0022832
GeneOntologyMolecularFunctionmonoatomic cation channel activity

TRPA1 SCN1A SCN2A SCN3A SCN10A CACHD1

1.19e-03343696GO:0005261
GeneOntologyBiologicalProcessneuronal action potential

TRPA1 SCN1A SCN2A SCN3A SCN10A

2.19e-0663695GO:0019228
GeneOntologyBiologicalProcessmembrane depolarization during action potential

SCN1A SCN2A SCN3A SCN10A

6.23e-0636694GO:0086010
GeneOntologyBiologicalProcesstransmission of nerve impulse

TRPA1 SCN1A SCN2A SCN3A SCN10A

3.68e-05112695GO:0019226
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception

TRPA1 SCN1A SCN10A ADGRV1

3.96e-0557694GO:0050974
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

SCN1A SCN2A SCN3A SCN10A

5.53e-0562694GO:0086002
GeneOntologyBiologicalProcessdetection of mechanical stimulus

TRPA1 SCN1A SCN10A ADGRV1

1.17e-0475694GO:0050982
GeneOntologyBiologicalProcesssensory perception of mechanical stimulus

TRPA1 MYO1A SCN1A SCN10A ADGRV1 PKHD1L1

1.45e-04238696GO:0050954
GeneOntologyBiologicalProcessactin filament-based movement

MYO1A SCN1A SCN2A SCN3A SCN10A

1.61e-04153695GO:0030048
GeneOntologyBiologicalProcessresponse to mechanical stimulus

TRPA1 SCN1A NFKBIA SCN10A ADGRV1 PSPH

1.77e-04247696GO:0009612
GeneOntologyBiologicalProcesscardiac muscle cell action potential

SCN1A SCN2A SCN3A SCN10A

2.07e-0487694GO:0086001
GeneOntologyBiologicalProcesscardiac muscle cell contraction

SCN1A SCN2A SCN3A SCN10A

2.68e-0493694GO:0086003
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN1A SCN2A SCN3A SCN10A

2.50e-0717694GO:0001518
GeneOntologyCellularComponentsodium channel complex

SCN1A SCN2A SCN3A SCN10A

2.43e-0629694GO:0034706
GeneOntologyCellularComponentpresynapse

TENM3 SYNJ1 VPS33B GIT1 SCN1A SCN2A IQSEC2 SCN10A GABBR2 DENND1A OPHN1

1.43e-048866911GO:0098793
GeneOntologyCellularComponentpresynaptic membrane

TENM3 SCN1A SCN2A SCN10A GABBR2 DENND1A

3.05e-04277696GO:0042734
GeneOntologyCellularComponentaxon

TRPA1 MYO1A TENM3 SYNJ1 GIT1 SCN1A SCN2A SCN3A SCN10A OPHN1

6.53e-048916910GO:0030424
GeneOntologyCellularComponentsynaptic membrane

TENM3 SYNJ1 SCN1A SCN2A IQSEC2 SCN10A GABBR2 DENND1A

6.54e-04583698GO:0097060
GeneOntologyCellularComponentcluster of actin-based cell projections

TRPA1 MYO1A ADGRV1 PKHD1L1 B4GALT1

8.53e-04223695GO:0098862
GeneOntologyCellularComponentcation channel complex

SCN1A SCN2A SCN3A SCN10A CACHD1

1.08e-03235695GO:0034703
DomainNa_channel_asu

SCN1A SCN2A SCN3A SCN10A

3.32e-0810684IPR001696
DomainNa_trans_assoc

SCN1A SCN2A SCN3A SCN10A

3.32e-0810684IPR010526
DomainNa_trans_assoc

SCN1A SCN2A SCN3A SCN10A

3.32e-0810684PF06512
DomainIQ_motif_EF-hand-BS

MYO1A SCN1A SCN2A IQSEC2 SCN3A SCN10A

9.11e-0790686IPR000048
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A

9.16e-076683PF11933
DomainNa_trans_cytopl

SCN1A SCN2A SCN3A

9.16e-076683IPR024583
DomainIQ

MYO1A SCN1A SCN2A IQSEC2 SCN3A SCN10A

1.11e-0693686PS50096
DomainIQ

MYO1A SCN1A IQSEC2 SCN3A SCN10A

5.96e-0671685PF00612
DomainChannel_four-helix_dom

SCN1A SCN2A SCN3A SCN10A

5.49e-0557684IPR027359
Domain-

SCN1A SCN2A SCN3A SCN10A

5.49e-05576841.20.120.350
DomainIon_trans_dom

TRPA1 SCN1A SCN2A SCN3A SCN10A

5.95e-05114685IPR005821
DomainIon_trans

TRPA1 SCN1A SCN2A SCN3A SCN10A

5.95e-05114685PF00520
DomainAnk_2

ANKRD42 TRPA1 GIT1 ASPG NFKBIA KANK2

1.31e-04215686PF12796
DomainIQ

MYO1A SCN1A SCN2A SCN3A

2.17e-0481684SM00015
Domain-

ANKRD42 TRPA1 GIT1 ASPG NFKBIA KANK2

2.84e-042486861.25.40.20
DomainANK

ANKRD42 TRPA1 GIT1 ASPG NFKBIA KANK2

3.03e-04251686SM00248
DomainANK_REPEAT

ANKRD42 TRPA1 GIT1 ASPG NFKBIA KANK2

3.16e-04253686PS50088
DomainAnkyrin_rpt-contain_dom

ANKRD42 TRPA1 GIT1 ASPG NFKBIA KANK2

3.22e-04254686IPR020683
DomainANK_REP_REGION

ANKRD42 TRPA1 GIT1 ASPG NFKBIA KANK2

3.22e-04254686PS50297
DomainAnkyrin_rpt

ANKRD42 TRPA1 GIT1 ASPG NFKBIA KANK2

3.80e-04262686IPR002110
DomainAnk

ANKRD42 TRPA1 GIT1 NFKBIA KANK2

1.45e-03228685PF00023
DomainCupredoxin

CP PKHD1L1

2.88e-0322682IPR008972
Domain-

SYNJ1 SMPD3

4.01e-03266823.60.10.10
DomainExo_endo_phos

SYNJ1 SMPD3

4.01e-0326682PF03372
DomainEndo/exonuclease/phosphatase

SYNJ1 SMPD3

4.32e-0327682IPR005135
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN1A SCN2A SCN3A SCN10A

4.11e-0631504M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN1A SCN2A SCN3A SCN10A

4.68e-0632504M27455
PathwayWP_DRAVET_SYNDROME

SCN1A SCN2A SCN3A

1.29e-0428503M45519
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN1A SCN2A SCN3A SCN10A

2.12e-10669423652591
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN1A SCN2A SCN3A SCN10A

1.77e-09969416382098
Pubmed

Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

SCN1A SCN2A SCN3A

7.47e-09369312610651
Pubmed

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.

SCN1A SCN2A SCN3A

7.47e-09369323859570
Pubmed

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

SCN1A SCN2A SCN3A

7.47e-09369318784617
Pubmed

Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.

SCN1A SCN2A SCN3A

7.47e-09369317544618
Pubmed

Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.

SCN1A SCN2A SCN3A

7.47e-09369314973256
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN1A SCN2A SCN3A SCN10A

1.00e-081369415123669
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN1A SCN2A SCN3A

2.99e-08469317537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN1A SCN2A SCN3A

2.99e-08469335031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN1A SCN2A SCN3A

2.99e-08469329578003
Pubmed

Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.

SCN1A SCN2A SCN3A

2.99e-08469335801810
Pubmed

Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.

SCN1A SCN2A SCN3A

2.99e-0846938974318
Pubmed

Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.

SCN1A SCN2A SCN3A

7.45e-0856931679748
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN1A SCN2A SCN3A

7.45e-0856938812438
Pubmed

Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.

SCN1A SCN2A SCN3A

7.45e-08569324337656
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

ABCB7 SYNJ1 VPS33B GIT1 CP TAF2 TNRC6C TBC1D23 PC KANK2 PFDN6 PCID2

1.07e-07853691228718761
Pubmed

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.

TRPA1 SCN3A SCN10A

1.49e-07669323711479
Pubmed

Significant determinants of mouse pain behaviour.

TRPA1 SCN3A SCN10A

4.16e-07869325101983
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN1A SCN2A SCN3A

6.22e-07969315746173
Pubmed

Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.

SCN1A SCN2A SCN3A

1.62e-06126938169823
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN1A SCN2A SCN3A

1.62e-061269330175250
Pubmed

Confirmation of quantitative trait loci for alcohol preference in mice.

SCN1A SCN2A SCN3A

3.34e-06156939726281
Pubmed

Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures.

SCN1A SCN2A

3.88e-06269229649454
Pubmed

Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.

SCN2A SCN3A

3.88e-06269220346423
Pubmed

Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.

SCN1A SCN2A

3.88e-06269210827969
Pubmed

Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population.

SCN1A SCN2A

3.88e-06269219694741
Pubmed

Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.

SCN2A SCN3A

3.88e-06269211245985
Pubmed

Differential expression of two sodium channel subtypes in human brain.

SCN1A SCN2A

3.88e-0626921317301
Pubmed

Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.

SCN2A SCN3A

3.88e-06269223016767
Pubmed

Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.

SCN2A SCN3A

3.88e-06269227153334
Pubmed

Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.

SCN1A SCN2A

3.88e-06269233096315
Pubmed

Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A.

SCN1A SCN3A

3.88e-06269224990319
Pubmed

Clinical exome sequencing identifies two novel mutations of the SCN1A and SCN2A genes in Moroccan patients with epilepsy: a case series.

SCN1A SCN2A

3.88e-06269231439038
Pubmed

Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures.

SCN1A SCN2A

3.88e-06269226311622
Pubmed

Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A.

SCN1A SCN2A

3.88e-06269215249644
Pubmed

Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a.

SCN1A SCN3A

3.88e-06269227690330
Pubmed

The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe.

SCN1A SCN2A

3.88e-06269221377452
Pubmed

Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome.

SCN1A SCN3A

3.88e-06269223965409
Pubmed

SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.

SCN1A SCN2A

3.88e-06269230693367
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SYNJ1 GIT1 IQSEC2 FIP1L1 ASTN1 CACHD1 PRKDC SMPD3 TBC1D23 PC KANK2 RASAL2

7.73e-061285691235914814
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PCNX2 MDN1 PSME4 SYNJ1 CHD5 PRKDC DTX2 TNRC6C RALGAPA2 PC DENND1A

1.07e-051105691135748872
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

SNRNP40 RBM5 FIP1L1 PRKDC TAF2 PCID2

1.09e-0525169631076518
Pubmed

Voltage-gated sodium channels in taste bud cells.

SCN2A SCN3A

1.16e-05369219284629
Pubmed

Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2.

SCN1A SCN2A

1.16e-05369228784306
Pubmed

Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.

SCN1A SCN2A

1.16e-05369232185219
Pubmed

Clinical exome sequencing as the first-tier test for diagnosing developmental disorders covering both CNV and SNV: a Chinese cohort.

SCN1A SCN2A

1.16e-05369232005694
Pubmed

Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia.

TRPA1 SCN10A

1.16e-05369229505031
Pubmed

Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).

SCN1A SCN3A

1.16e-05369233895391
Pubmed

Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.

SCN3A SCN10A

1.16e-05369219699781
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN1A SCN2A

1.16e-05369232845893
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN1A SCN2A

1.16e-05369228518218
Pubmed

GAPDH-mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions.

SCN1A SCN3A

1.16e-05369227816501
Pubmed

Gene-to-gene interaction between sodium channel-related genes in determining the risk of antiepileptic drug resistance.

SCN1A SCN2A

1.16e-05369219270815
Pubmed

Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells.

SCN2A SCN3A

1.16e-05369216052353
Pubmed

Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy.

SCN1A SCN2A

1.16e-05369225155934
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN1A SCN2A

1.16e-05369217928448
Pubmed

Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice.

SCN3A SCN10A

1.16e-05369217052333
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

WDR74 NAA35 MDN1 PSME4 VPS33B SNRNP40 FIP1L1 PRKDC TAF2 GRSF1 PCID2 RASAL2

1.30e-051353691229467282
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

TENM3 NFKBIA RBM5 FIP1L1 PRKDC PC PKHD1L1 GRSF1 RASAL2

2.27e-0577769935844135
Pubmed

Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.

SCN1A SCN2A

2.32e-05469226637798
Pubmed

Tumor necrosis factor-alpha-inducible IkappaBalpha proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappab activation.

NFKBIA CAPN3

2.32e-0546929873017
Pubmed

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

SCN1A SCN2A

2.32e-05469221156207
Pubmed

Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling.

TRPA1 SCN10A

2.32e-05469222850668
Pubmed

Dorsal root ganglia isolated from Nf1+/- mice exhibit increased levels of mRNA expression of voltage-dependent sodium channels.

SCN1A SCN10A

2.32e-05469222260870
Pubmed

Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain.

TRPA1 SCN10A

2.32e-05469232687056
Pubmed

Homeostatic pruning and activity of epidermal nerves are dysregulated in barrier-impaired skin during chronic itch development.

TRPA1 SCN10A

2.32e-05469231197234
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

WDR74 NAA35 ABCB7 IQSEC2 GPAT3 MAIP1 PRKDC TAF2 TBC1D23 PCID2 B4GALT1

2.35e-051203691129180619
Pubmed

The functional interactome landscape of the human histone deacetylase family.

WDR74 MDN1 FIP1L1 MAIP1 PRKDC PFDN6

2.42e-0528969623752268
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

WDR74 TIGAR NAA35 ABCB7 MDN1 GPAT3 SNRNP40 KANK2 PFDN6 GRSF1 TMCC3 RASAL2

3.28e-051487691233957083
Pubmed

The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells.

MMS22L PRKDC

3.86e-05569229478807
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN2A SCN3A

3.86e-05569217724025
Pubmed

Involvement of TRPV1 and TDAG8 in Pruriception Associated with Noxious Acidosis.

TRPA1 SCN10A

3.86e-05569227566399
Pubmed

The fructose-2,6-bisphosphatase TIGAR suppresses NF-κB signaling by directly inhibiting the linear ubiquitin assembly complex LUBAC.

TIGAR NFKBIA

3.86e-05569229650758
Pubmed

DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells.

MDN1 TAF2 PCID2

4.67e-053569324515614
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

MDN1 SYNJ1 GIT1 IQSEC2 FIP1L1 PC DENND1A TMCC3 RASAL2

5.03e-0586169936931259
Pubmed

ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage.

NFKBIA PRKDC

5.79e-05669214966265
Pubmed

Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.

SCN1A SCN2A

8.09e-05769225818041
Pubmed

Pain without nociceptors? Nav1.7-independent pain mechanisms.

SCN3A SCN10A

8.09e-05769224440715
Pubmed

LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.

TIGAR PSPH PC

1.07e-044669335237793
Pubmed

Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis.

TRPA1 SCN10A

1.38e-04969228658621
Pubmed

Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse.

SCN3A SCN10A

1.38e-0496928854872
Pubmed

Common variants associated with general and MMR vaccine-related febrile seizures.

SCN1A SCN2A

1.73e-041069225344690
Pubmed

Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment.

SCN1A SCN2A

1.73e-041069220602612
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

TENM3 VPS33B CACHD1 RALGAPA2 GNS RASAL2

1.91e-0442169636976175
Pubmed

Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation.

TRPA1 SCN10A

2.11e-041169234338291
Pubmed

Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo.

FIP1L1 TAF2

2.11e-041169214729963
Pubmed

A comparative gene map of the horse (Equus caballus).

PRKDC TG

2.53e-041269210613847
Pubmed

BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.

SYNJ1 VPS33B TBC1D23 DENND1A GNS

2.61e-0428569534369648
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

MDN1 GPAT3 ALG11 MAIP1 TAF2 PFDN6 RASAL2

2.73e-0463869731182584
Pubmed

Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.

PRKDC TG

2.98e-041369222724066
Pubmed

Etv4 regulates nociception by controlling peptidergic sensory neuron development and peripheral tissue innervation.

TRPA1 SCN10A

2.98e-041369235904071
Pubmed

Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia.

TRPA1 SCN10A

2.98e-041369235263589
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

NAA35 CHD5 ZNF589 FIP1L1 MAIP1 TAF2 RALGAPA2 KANK2 PCID2

3.52e-04111669931753913
Pubmed

Report and abstracts of the Fourth International Workshop on Human Chromosome 2 Mapping 1996.

SCN1A SCN2A SCN3A

3.88e-04716938751373
Pubmed

Identification of potential protein interactors of Lrrk2.

MDN1 PRKDC

4.01e-041569217400507
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

WDR74 MDN1 SYNJ1 IQSEC2 TAF2 RASAL2 SGK3

4.33e-0468969736543142
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

WDR74 GIT1 SNRNP40 RBM5 FIP1L1 PFDN6 GRSF1 OPHN1

4.54e-0491669832203420
Pubmed

Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.

SCN10A PRDM6

4.57e-041669225035420
Pubmed

Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.

MDN1 PRKDC TNRC6C

4.74e-047669327542412
Cytoband2q24.3

SCN1A SCN2A

2.64e-04166922q24.3
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN2A SCN3A SCN10A

5.46e-0994841203
GeneFamilyAnkyrin repeat domain containing

ANKRD42 TRPA1 GIT1 ASPG NFKBIA KANK2

4.14e-05242486403
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM3 ACOT11 CHD5 ASTN1 PC GNS

4.73e-07188696a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN1A CHD5 SCN2A SCN3A GABBR2 RASAL2

6.41e-07198696c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN1A CHD5 SCN2A SCN3A GABBR2 RASAL2

6.41e-071986966d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN1A CHD5 SCN2A SCN3A GABBR2 RASAL2

6.41e-071986964ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

MDN1 TNRC6C ADGRV1 PC OPHN1

5.15e-06161695347edb0de10850b7d16c40945751033289289c9b
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ASPG SCN1A SCN3A PKHD1L1 SGK3

5.63e-061646954cfc9f92e49f86d3639e018b35b6a60dc62f494a
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ASPG SCN1A SCN3A PKHD1L1 SGK3

5.63e-061646957a8e5ef52a8fd2877d59ef0696af8a7af90bbed6
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ASPG SCN1A SCN3A PKHD1L1 SGK3

5.63e-061646955e5bd81414ea2d64f73cdef19a0a78c17bec8c18
ToppCellPND10-Endothelial-Endothelial_lymphatic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ASPG SCN1A SCN3A PKHD1L1 SGK3

5.63e-06164695f13b8d9b7f42193f333d9a77571a1dde6bbb48d8
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A ASTN1 PKHD1L1 SGK3

5.80e-06165695347b59aa625a8a960828b8620824d8ac48990e07
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A ASTN1 PKHD1L1 SGK3

5.80e-06165695507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCellPND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A ASTN1 PKHD1L1 SGK3

5.80e-0616569539a25be081a5d59c7cf107a997d352793d5025fb
ToppCellPND03-Endothelial-Endothelial_lymphatic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A ASTN1 PKHD1L1 SGK3

5.80e-061656951890f9c33b0c5b381d57f97042da2610a093a6de
ToppCelllymphoid-NK_cell-TNFRSF18+IL7R+_NK_cell|World / Lineage, cell class and subclass

SCN2A CAPN3 MYOM2 SMPD3 OPHN1

9.10e-061816950d096d7d557fd2e71b35e41816e11d7e83cd9210
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ACOT11 SCN2A SCN3A CACHD1 OPHN1

9.59e-061836952e831a4d99c6f983793df71c0994124c943c6da9
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN2A ROS1 MYOM2 ADGRV1 PKHD1L1

9.85e-061846952cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN2A ROS1 MYOM2 ADGRV1 PKHD1L1

9.85e-06184695ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN2A ROS1 MYOM2 ADGRV1 PKHD1L1

9.85e-061846952b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCNX2 SCN1A CHD5 SCN2A GABBR2

1.04e-051866957278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCelllymphoid-NK_cell-TNFRSF18+IL7R+_NK_cell|lymphoid / Lineage, cell class and subclass

SCN2A CAPN3 MYOM2 SMPD3 OPHN1

1.06e-0518769599dfa50f6325b0d66d23ee8dcaa6437e7161628a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ACOT11 SCN2A SCN3A CACHD1 OPHN1

1.09e-05188695bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ACOT11 SCN2A SCN3A CACHD1 OPHN1

1.09e-05188695eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CHD5 ASTN1 MYOM2 KANK2 PRDM6

1.12e-051896957fbe855bfdb47d35e040b04a80fe4b729a3764e8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CHD5 ASTN1 MYOM2 KANK2 PRDM6

1.12e-0518969506b35abecd29f902cf251fcc1f6ad33db7ab08a2
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCNX2 SCN1A CHD5 SCN2A GABBR2

1.24e-05193695be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCNX2 SCN1A CHD5 SCN2A GABBR2

1.24e-051936950c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCNX2 SCN1A CHD5 SCN2A GABBR2

1.24e-051936958689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellHippocampus-Neuronal|Hippocampus / BrainAtlas - Mouse McCarroll V32

PCNX2 SYNJ1 CHD5 SCN2A GABBR2

1.27e-051946958aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCNX2 CHD5 SCN2A SCN3A SMPD3

1.30e-05195695ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CHD5 SCN2A SCN3A GABBR2 RASAL2

1.34e-05196695676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellControl_saline-Epithelial_airway|Control_saline / Treatment groups by lineage, cell group, cell type

CP ODAD4 CEP126 CFAP44 RSPH10B

1.40e-05198695e6863238e022ecfb6a8e3f4b7661b376e92c5d8f
ToppCellControl_saline-Epithelial_airway-airway_epithelial|Control_saline / Treatment groups by lineage, cell group, cell type

CP ODAD4 CEP126 CFAP44 RSPH10B

1.40e-05198695e7aa42e5fbd42c68f50cda4a8f3aa464c862c007
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CHD5 SCN2A SCN3A GABBR2 RASAL2

1.40e-051986950ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

CHD5 SCN2A SCN3A GABBR2 RASAL2

1.47e-0520069548d801219bc771d6c7e151dc88ca4c179988de85
ToppCellControl-NK|World / Disease group and Cell class

ACOT11 IQSEC2 CACHD1 RASAL2

7.20e-05143694fe08adc9472dfd4242497d6c614d0490713261da
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN1A SCN10A ROS1 ADGRV1

7.60e-0514569496712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCelldroplet-Heart-nan-24m-Mesenchymal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CP ADGRV1 PC PRDM6

1.09e-041596947ad3a91d29639b32f6264c91f401c14a35469ac0
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SCN10A ROS1 ADGRV1 PKHD1L1

1.17e-04162694bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5|TCGA-Ovary / Sample_Type by Project: Shred V9

PCNX2 ACOT11 ZNF589 CFAP44

1.28e-0416669432d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

GPAT3 MYOM2 DENND1A TMCC3

1.34e-0416869494cded2e953c0970bf2f3dbe0ce46bd77a5ed8c7
ToppCellControl-NK|Control / Disease group and Cell class

ACOT11 IQSEC2 CACHD1 TMCC3

1.34e-04168694683d389c8a1e791bfc773e63148115a21a6566db
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A GABBR2 SGK3

1.37e-04169694f077e39e41fffe7672541f5b72b80faaf56c597c
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFKBIA SCN3A ADGRV1 PKHD1L1

1.37e-0416969412bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A GABBR2 SGK3

1.40e-0417069435e3945d8a540a3e2cec1b559316265aaad023d1
ToppCellPND01-Endothelial-Endothelial_lymphatic|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A GABBR2 SGK3

1.40e-041706940ea625abaa25bab93b70b7000e8f90d5c0f9a0fb
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN1A SCN3A GABBR2 SGK3

1.40e-041706940b5ddc7d452db0a389927a367914f7d257703f7e
ToppCelldroplet-Marrow-nan-18m-Lymphocytic-plasma_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IQSEC2 CP GNS TMCC3

1.40e-04170694067657ca7fcf5a0ffbd168b5c4609a30ca508f22
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_TMEM233|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 MYOM2 CACHD1 TG

1.44e-04171694fdd96c6fe850bd10e1e0d0f18c4401f8348b7d2c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ACOT11 SCN2A CACHD1 OPHN1

1.50e-041736944bc6d93716f093b460c8b047199db8cab5fea720
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCNX2 TENM3 SMPD3 PKHD1L1

1.50e-0417369430d67738633493d47f06ae452424382f069b6c0a
ToppCell3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCN2A SCN3A ADGRV1 GABBR2

1.54e-04174694a62531ebf16b32b249168dca11b870f63a8aa81c
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ASPG CP CEP126 CFAP44

1.60e-04176694dee780cfa85234a7cd7bf440b66b84cec959893e
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_TMEM233|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM3 MYOM2 CACHD1 TG

1.68e-04178694c655b72ec22d45d2da69c2d8886a01831ce79558
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SCN2A SCN3A CACHD1 OPHN1

1.71e-04179694666072c0e8448dbaec1683d18368ec2502453f90
ToppCellPCW_13-14-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TRPA1 SCN1A SCN2A SCN3A

1.71e-04179694af0b54c9ea0b6e4210f22dbb6e88ecd3276a5f86
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

SCN1A ROS1 CACHD1 ADGRV1

1.75e-04180694198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ACOT11 SCN2A CACHD1 OPHN1

1.79e-04181694e0abf2707d9e0aa942c657eef7d2cbcd02f060dd
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

CP ROS1 CACHD1 ADGRV1

1.79e-04181694c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCellwk_08-11-Mesenchymal-Mesothelial-Late_mesothelial|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

GIT1 ASPG SMPD3 PKHD1L1

1.82e-04182694f8257c884393f168f605d371e0840cfca8d3657e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SCN2A SCN3A CACHD1 OPHN1

1.82e-041826945f513bbb7125956eb528e3120de3fd776770a7c3
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ACOT11 SCN2A CACHD1 OPHN1

1.86e-041836942f0ee40e69ad1259e56e8ee4b352736900eb8901
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

SCN1A ROS1 CACHD1 ADGRV1

1.90e-04184694369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

CP ROS1 CACHD1 ADGRV1

1.94e-04185694cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCN3A ROS1 CEP126 ADGRV1

1.94e-04185694eb78614c4acf8d2ce7874d7e51e16997b76127ef
ToppCell343B-Fibroblasts-Fibroblast-E-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

PSME4 GIT1 SCN2A CFAP44

1.94e-041856941b8e3ddb91797f84e4b15d2457b0c008e5be50db
ToppCell343B-Fibroblasts-Fibroblast-E|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

PSME4 GIT1 SCN2A CFAP44

1.94e-0418569402cbf492bc40abebaa93a3a208888afae72fbe06
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHD5 SCN2A ASTN1 GABBR2

1.98e-0418669418fd311252299d6d30ddb32002ed069056108206
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SCN2A SCN10A ASTN1 ADGRV1

1.98e-0418669423b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ASPG CHD5 SMPD3 PKHD1L1

2.02e-041876948e8f1f2a78ac5f13a414fd448af7d7ff1ea86f0f
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SYNJ1 CHD5 SCN2A SCN3A

2.06e-04188694b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D231|Adult / Lineage, Cell type, age group and donor

SCN1A ROS1 CACHD1 ADGRV1

2.11e-04189694dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCellEpithelial-D_(Ciliated)|World / shred on cell class and cell subclass (v4)

ANKRD42 ODAD4 CFAP44 RSPH10B

2.11e-041896940bf560b595c7a8450a46bc821b742b67965bd9f9
ToppCellRA-10._Endothelium_II|World / Chamber and Cluster_Paper

CP RALGAPA2 PKHD1L1 DENND1A

2.11e-0418969475c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCellRA-10._Endothelium_II|RA / Chamber and Cluster_Paper

CP RALGAPA2 PKHD1L1 DENND1A

2.11e-04189694c81787a8c662db5d7814c583dd64562857629e81
ToppCelllymphoid-NK_cell-TNFRSF18+IL7R+_NK_cell|NK_cell / Lineage, cell class and subclass

SCN2A NFKBIA CAPN3 SMPD3

2.15e-0419069416e408436fa663cdf86e38311a7aed4e02c28579
ToppCellCOVID-19-lung-AT2|COVID-19 / Disease (COVID-19 only), tissue and cell type

SCN1A ROS1 CACHD1 ADGRV1

2.15e-0419069427a1a86620fe9b5ee930d388b32352206485e6d0
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

CHD5 SCN2A SCN3A CEP126

2.15e-041906946e92c78799f34b31d098854503c796edb0dc7f80
ToppCellPND03-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANKRD42 ODAD4 CFAP44 RSPH10B

2.19e-04191694bda8faf92495c8b362850c0aff4fc6fbdd9c563b
ToppCellPND03-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANKRD42 ODAD4 CFAP44 RSPH10B

2.19e-041916946880fb348bb0915db9a5da4f3566ca9ff93ed258
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2|Children_(3_yrs) / Lineage, Cell type, age group and donor

SCN1A ROS1 CACHD1 ADGRV1

2.19e-04191694a0332a4ef629510fb313ec119195c44a3f704a80
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACOT11 ASTN1 PC GNS

2.19e-041916943387b95a3f2445c672d407922fdce3a91eabaef8
ToppCellCOVID-19-lung-AT2|lung / Disease (COVID-19 only), tissue and cell type

SCN1A ROS1 CACHD1 ADGRV1

2.19e-04191694276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PCNX2 SYNJ1 CHD5 SCN2A

2.19e-041916945d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCellEntopeduncular-Neuronal-Inhibitory|Entopeduncular / BrainAtlas - Mouse McCarroll V32

PCNX2 SYNJ1 CHD5 SCN2A

2.19e-0419169473dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCellPND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANKRD42 ODAD4 CFAP44 RSPH10B

2.19e-0419169496483adb97c81208aa513782550acd8a08b63866
ToppCellCOVID-19-Heart-EC_(POSTN)|Heart / Disease (COVID-19 only), tissue and cell type

CP RALGAPA2 PKHD1L1 DENND1A

2.24e-04192694c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCellwk_08-11-Mesenchymal-Mesothelial-intermediate_mesothelial|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ASPG CHD5 SMPD3 PKHD1L1

2.24e-04192694ac9e5288ecd4b1e142f2e15a1fcd11c8eb9e15cd
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM3 ACOT11 GABBR2 PC

2.24e-041926945b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCellfacs-Heart-LA-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CP SMPD3 RALGAPA2 PKHD1L1

2.24e-0419269414a816ef116aa992f86edab411f043cf7d07fe04
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SCN3A ASTN1 MYOM2 PRDM6

2.24e-04192694bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCellPND03-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANKRD42 ODAD4 CFAP44 RSPH10B

2.24e-04192694b5cdc2dae3154b1e4ade88f841f38584402ffe33
ToppCellEpithelial-alveolar_epithelial_cell_type_2|World / Lineage, Cell type, age group and donor

SCN1A ROS1 CACHD1 ADGRV1

2.24e-0419269458c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SCN1A ROS1 CACHD1 ADGRV1

2.24e-04192694cc9911e182a289779a2612bc213daae5607689e7
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SCN3A ASTN1 MYOM2 PRDM6

2.24e-04192694b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCellfacs-Heart-LA-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CP SMPD3 RALGAPA2 PKHD1L1

2.24e-04192694847822514d747a21d5eb40e04ba9a023fd32bd65
ToppCellPND03-Epithelial-Epithelial_Airway|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANKRD42 ODAD4 CFAP44 RSPH10B

2.24e-041926942d8d5a38e205339eda9c8aca1ca9ba3dcbe5ae56
ToppCellASK452-Epithelial-Ciliated|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

CP ODAD4 CEP126 CFAP44

2.28e-04193694c0d10075862ac878aa05fc49c8b73e470783bf16
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SCN1A ROS1 CACHD1 ADGRV1

2.28e-04193694fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CACHD1 CEP126 ADGRV1 CFAP44

2.28e-04193694ea345d34440b25f65358a53dc72831998d1c3620
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2|Adult / Lineage, Cell type, age group and donor

SCN1A ROS1 CACHD1 ADGRV1

2.28e-04193694738f4f0a9ddde2432b429ab46838e353b1790589
DrugAPETx1, Anthopleura elegantissima

SCN2A SCN3A SCN10A

5.29e-076693ctd:C475726
Drugfenpropathrin

SCN2A SCN3A SCN10A

5.29e-076693ctd:C044267
Drug2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate

SCN2A SCN3A SCN10A

1.48e-068693ctd:C489827
Drugdecamethrin

PSME4 SCN1A SCN2A NFKBIA SCN3A SCN10A

5.39e-06146696ctd:C017180
DrugZonisamide

SCN1A SCN2A SCN3A

1.76e-0517693DB00909
DrugAC1NRC8M

SCN2A NFKBIA SCN3A

2.49e-0519693CID005288877
DrugClidinium bromide [3485-62-9]; Down 200; 9.2uM; HL60; HT_HG-U133A

TIGAR SYNJ1 ZNF589 RBM5 PSPH GNS

2.96e-051976962734_DN
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN10A

5.05e-0910674DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN10A

5.05e-0910674DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN10A

1.19e-0812674DOID:0060170 (implicated_via_orthology)
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN1A SCN2A ADGRV1

9.31e-079673C3502809
Diseaseanxiety disorder (implicated_via_orthology)

SCN1A SCN2A SCN3A

1.67e-0522673DOID:2030 (implicated_via_orthology)
DiseaseSeizure, Febrile, Simple

SCN1A SCN2A

1.06e-047672C0149886
DiseaseSeizure, Febrile, Complex

SCN1A SCN2A

1.06e-047672C0751057
DiseaseEpilepsy

SCN1A SCN2A IQSEC2 ASTN1

1.13e-04109674C0014544
Diseaseresponse to simvastatin, PCSK9 protein measurement

GABBR2 CFAP44

1.81e-049672EFO_0006899, GO_1903491
DiseaseFebrile Convulsions

SCN1A SCN2A

1.81e-049672C0009952
DiseaseInfantile Severe Myoclonic Epilepsy

SCN1A SCN2A

3.90e-0413672C0751122
DiseaseMMR-related febrile seizures

SCN1A SCN2A

5.23e-0415672EFO_0006519
Disease3-hydroxyanthranilic acid measurement

PCNX2 TG

5.23e-0415672EFO_0010447
Diseaseepilepsy (implicated_via_orthology)

SCN1A SCN2A SCN3A SCN10A

5.25e-04163674DOID:1826 (implicated_via_orthology)
DiseaseTremor, Rubral

ABCB7 CP

5.97e-0416672C0750940
DiseaseAtaxia, Appendicular

ABCB7 CP

5.97e-0416672C0750937
DiseaseAtaxia, Motor

ABCB7 CP

5.97e-0416672C0278161
DiseaseAbnormal coordination

ABCB7 CP

5.97e-0416672C0520966
DiseaseAtaxia, Truncal

ABCB7 CP

5.97e-0416672C0427190
DiseaseAtaxia, Sensory

ABCB7 CP

5.97e-0416672C0240991
DiseaseEarly infantile epileptic encephalopathy with suppression bursts

SCN1A SCN2A

5.97e-0416672C0393706
Diseaseserine measurement, amino acid measurement

ASPG PSPH

6.76e-0417672EFO_0005134, EFO_0009774
DiseaseFebrile seizure (within the age range of 3 months to 6 years)

SCN1A SCN2A

7.59e-0418672HP_0002373
DiseaseEpilepsy, Cryptogenic

SCN1A SCN2A IQSEC2

8.72e-0482673C0086237
DiseaseAwakening Epilepsy

SCN1A SCN2A IQSEC2

8.72e-0482673C0751111
DiseaseAura

SCN1A SCN2A IQSEC2

8.72e-0482673C0236018
Diseasesciatic neuropathy (implicated_via_orthology)

NFKBIA SCN10A

1.25e-0323672DOID:11446 (implicated_via_orthology)
DiseaseNeurodevelopmental Disorders

SCN1A SCN2A IQSEC2

1.25e-0393673C1535926
DiseaseAtaxia

ABCB7 CP

1.47e-0325672C0004134
DiseaseMental Retardation, X-Linked

IQSEC2 OPHN1

1.98e-0329672C1136249

Protein segments in the cluster

PeptideGeneStartEntry
NVNGQQILEGAFRRF

ALG11

106

Q2TAA5
KNQNIGFNNAAFITR

ALG11

211

Q2TAA5
IFNRAKLLNVGFQEA

B4GALT1

221

P15291
VLGFNARQRKAFLNA

CHD5

1421

Q8TDI0
KIIGQNLELNFANFS

ADGRV1

2741

Q8WXG9
GFQKAFQLIRSTNNN

CACHD1

316

Q5VU97
GQVVNIKAKVNRAFN

ACOT11

106

Q8WXI4
NQGRQKLARFNAREF

GIT1

326

Q9Y2X7
FQAAIGENNKFANFL

CFAP44

1471

Q96MT7
QVLKGTFRQNNFARG

ASTN1

751

O14525
GENVLDLAQRFFKQN

ANKRD42

201

Q8N9B4
VGSNIQVQKLLNAFF

OPHN1

411

O60890
QANAQDIINFFAPLK

GRSF1

411

Q12849
LNHLKAGLQAFFQVQ

CP

341

P00450
NAFQIKGNLFREQQR

RSPH10B

531

P0C881
AAVQAARNANIFVIF

MDN1

5511

Q9NU22
RGASVFQVKLGNQNV

MAIP1

241

Q8WWC4
FQNQLFRGNRATKVD

ASPG

176

Q86U10
VLEAFGNAKTIRNNN

MYO1A

141

Q9UBC5
FIEQQFVQQKGQRFG

DTX2

41

Q86UW9
NIGAFVNQNQIKLFP

MMS22L

191

Q6ZRQ5
FLGNRQKQFNRDVLD

IQSEC2

806

Q5JU85
INQFQQKFGAAILHI

EXD1

81

Q8NHP7
AKTTAFFQGNRQRQI

PCNX2

656

A6NKB5
LQQEFQRAQAAKAGA

PFDN6

111

O15212
AAANVQVNKIYGLFV

OR52A1

191

Q9UKL2
IQDGRFNLFKVQQGR

FIP1L1

226

Q6UN15
AKVIQNLANFAKFGN

RASAL2

511

Q9UJF2
QVKGDLAFLNFQNNL

NFKBIA

96

P25963
VNNLFNTQARAKEIG

SMPD3

141

Q9NY59
NTNVKAGVQALLQVF

RALGAPA2

501

Q2PPJ7
KDKQTQQNRGFAFVQ

RBM5

266

P52756
SGFNQINVKNQRVLA

PRDM6

441

Q9NQX0
RVFANNADQQLVKKG

PCID2

116

Q5JVF3
VQFANRVKSAIAIQG

GPAT3

381

Q53EU6
NQSFKFGNQKAAAIR

CEP126

596

Q9P2H0
KAFQNVFAPRNKNFN

GNS

246

P15586
QNATQLQLFKQFIDG

DENND1A

356

Q8TEH3
ASAFLFFNIKNRNQK

GABBR2

496

O75899
FRLGNINAKASQAGQ

KANK2

726

Q63ZY3
QQQFRNIFKQIAGDD

CAPN3

651

P20807
FIKQRRAGLNEFIQN

SGK3

86

Q96BR1
QAQLLQFAAKNIGLN

TNRC6C

1121

Q9HCJ0
FKQAAAAGIFLNNVK

TIGAR

36

Q9NQ88
NNADKQQAGRIKQVF

TMCC3

101

Q9ULS5
NVNGGKQFRSIAFKN

SYNJ1

541

O43426
INQKNAGQVFRGFLE

SYNJ1

761

O43426
NNINFQRKSVVGFVE

TAF2

36

Q6P1X5
FRVGIQKAQEAINNS

ODAD4

116

Q96NG3
IFQGNVHNFEKNLLR

SNRNP40

276

Q96DI7
NLFIGVIIDNFNQQK

SCN3A

1461

Q9NY46
SGQGFQNKNRVAILA

INIP

6

Q9NRY2
NLFIGVIIDNFNQQK

SCN1A

1476

P35498
FNEVRNAVFGKVAQN

ABCB7

206

O75027
KGVNLQRKQAANFTA

WDR74

21

Q6RFH5
KDNFGRNFLHLTVQQ

TRPA1

371

O75762
GNQVNRKVLNFEQAI

NAA35

76

Q5VZE5
FGGNVIRQQVKDNAK

PSPH

196

P78330
NLFVGVIIDNFNQQK

SCN10A

1411

Q9Y5Y9
LQANQLQGEGVRFFV

TBC1D23

326

Q9NUY8
NLFIGVIIDNFNQQK

SCN2A

1466

Q99250
FGVQQQVARQAKAFL

TENM3

2451

Q9P273
NLKGIFQFRVVAANN

ROS1

1821

P08922
LANKGIFLEHFQVNQ

PKHD1L1

851

Q86WI1
QVRNKAQQTFFAALG

PSME4

981

Q14997
NAFKRLGASLAFNNI

PRKDC

1071

P78527
ALAFNQKSNLFRQKA

ZNF589

221

Q86UQ0
RLQQNLFGGKFLVNV

TG

466

P01266
AGQRQVFFELNGQLR

PC

1071

P11498
NVFGFLSQKARNLQA

VPS33B

296

Q9H267
QQFKAAAFAEKNRGR

MYOM2

1331

P54296