Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionintracellular sodium-activated potassium channel activity

KCNT2 KCNT1

3.46e-0521182GO:0005228
DomainARM-type_fold

CAND1 NEK10 UBR4 NOC3L MEI1 ARFGEF3 URB1 LTN1 ASPM INTS4 ULK4 UTP20 STAG2

1.54e-0733911413IPR016024
DomainARM-like

CAND1 NEK10 NOC3L MEI1 LTN1 ASPM INTS4 ULK4 UTP20 STAG2

6.13e-0627011410IPR011989
DomainKH_dom-like_a/b

RPS3 RBFA

1.10e-0431142IPR015946
DomainSTPPase_N

PPP1CA PPP1CC

1.10e-0431142IPR031675
DomainSTPPase_N

PPP1CA PPP1CC

1.10e-0431142PF16891
Domain-

RPS3 RBFA

1.10e-04311423.30.300.20
DomainK_chnl_Ca-activ_BK_asu

KCNT2 KCNT1

2.20e-0441142IPR003929
DomainBK_channel_a

KCNT2 KCNT1

2.20e-0441142PF03493
DomainPeptidase_A22B_SPP

SPPL2B SPPL2A

3.65e-0451142IPR007369
DomainPeptidase_A22B

SPPL2B SPPL2A

3.65e-0451142PF04258
DomainPSN

SPPL2B SPPL2A

7.60e-0471142SM00730
DomainPreselin/SPP

SPPL2B SPPL2A

7.60e-0471142IPR006639
DomainHEAT_REPEAT

CAND1 INTS4 ULK4 UTP20

8.85e-04701144PS50077
DomainTMC

TMC7 TMC6

1.01e-0381142PF07810
DomainTMC

TMC7 TMC6

1.01e-0381142IPR012496
DomainIL-1_rcpt_fam

IL1RAPL2 SIGIRR

1.96e-03111142IPR015621
DomainMBOAT_fam

PORCN LPCAT3

1.96e-03111142IPR004299
DomainMBOAT

PORCN LPCAT3

1.96e-03111142PF03062
DomainWD40_repeat_dom

IFT140 UBR4 DDB1 LLGL2 WDR11 HERC1 WDR13

2.32e-032971147IPR017986
Domain-

CAND1 NEK10 ASPM INTS4 ULK4 UTP20

2.42e-0322211461.25.10.10
DomainSer/Thr-sp_prot-phosphatase

PPP1CA PPP1CC

2.76e-03131142IPR006186
DomainSER_THR_PHOSPHATASE

PPP1CA PPP1CC

2.76e-03131142PS00125
DomainPP2Ac

PPP1CA PPP1CC

2.76e-03131142SM00156
DomainTPR-like_helical_dom

ADCY10 IFT140 OGT POLR1A TTC29 CFAP70

3.08e-032331146IPR011990
DomainHEAT

CAND1 INTS4 UTP20

3.14e-03481143PF02985
Domain-

IFT140 DDB1 LLGL2 WDR11 HERC1 WDR13 PLXNA1

4.35e-0333311472.130.10.10
DomainWD40/YVTN_repeat-like_dom

IFT140 DDB1 LLGL2 WDR11 HERC1 WDR13 PLXNA1

4.49e-033351147IPR015943
DomainHEAT

CAND1 INTS4 UTP20

5.35e-03581143IPR000357
DomainPA

SPPL2B SPPL2A

5.90e-03191142PF02225
DomainPA_domain

SPPL2B SPPL2A

5.90e-03191142IPR003137
DomainMyosin-like_IQ_dom

MYH10 ASPM

5.90e-03191142IPR027401
Domain-

MYH10 ASPM

5.90e-031911424.10.270.10
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

MYH10 CAND1 POLR1A RPS3 POLE UBR4 NOC3L FAM98A DDB1 NT5DC1 PPP1CA PPP1CC LONP1 URB1 DIMT1 WDR11 FDPS LTN1 ASPM BYSL MACF1 UTP20 HERC2 WDR13

2.97e-1113531192429467282
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MYH10 POLR1A POLE UBR4 NOC3L DDB1 PPP1CA PPP1CC LONP1 URB1 BYSL MACF1 UTP20 CTNNA1 HERC2 STAG2

8.95e-106531191622586326
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

LZTR1 ITPRIPL2 ATP13A1 POLE UBR4 TMC6 PANX1 SPPL2B CNPPD1 FAM20C URB1 LLGL2 LRP3 KCNQ2 ULK4 HERC2 HERC1 PLXNA1 ABCC10

7.24e-0911051191935748872
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

CAND1 POLR1A POLE NOC3L FAM98A DDB1 URB1 DIMT1 DROSHA ASPM BYSL MACF1 UTP20 HERC2 MED23 HDAC1

7.56e-097591191635915203
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

CAND1 OGT POLR1A ATP13A1 NOC3L FAM98A PPP1CC URB1 DIMT1 WDR11 DROSHA LTN1 BYSL MACF1 UTP20 HERC2 MED23 STAG2 RBFA HDAC1

1.76e-0714971192031527615
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

MYH10 CAND1 POLR1A ATP13A1 RPS3 POLE UBR4 NOC3L DDB1 PPP1CA LONP1 URB1 DIMT1 BYSL UTP20 MED23 STAG2 PLXNA1 HDAC1

3.84e-0714251191930948266
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

CAND1 POLR1A ATP13A1 POLE UBR4 NOC3L CPD RTN2 ARFGEF3 URB1 BYSL UTP20 CTNNA1 ABHD12 STAG2

8.36e-079421191531073040
Pubmed

The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities.

HERC2P3 HERC2 HERC1

1.35e-06711939949213
Pubmed

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.

OGT RPS3 PPP1CA URB1 MED23 HDAC1

1.63e-06104119626167872
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

MYH10 CAND1 OGT POLR1A FRMPD2 TMC6 PORCN CPD SPPL2B ARFGEF3 WDR11 GPR137C SIGIRR LPCAT3 MACF1 ATP11A WDR13 STAG2

3.21e-0614891191828611215
Pubmed

Consensus PP1 binding motifs regulate transcriptional corepression and alternative RNA splicing activities of the steroid receptor coregulators, p54nrb and PSF.

PPP1CA PPP1CC HDAC1

3.23e-069119321566083
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

SELENOS ITPRIPL2 ATP13A1 SLC46A1 CPD FAM98A FAM20C LPCAT3 LTN1 INTS4 MACF1 CTNNA1 HERC1 PLXNA1 ABCC10

3.59e-0610611191533845483
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

CYSLTR2 HTR6 ATP13A1 UBR4 TMC6 GDPD2 PANX1 CTNNA1 TMCO3 HERC2 ABHD12 PIGM

5.14e-066971191228298427
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

MYH10 CAND1 OGT UBR4 GRM2 DDB1 PPP1CA PPP1CC FRY MACF1 CTNNA1 HERC2 KCNT1 LGI1

5.67e-069631191428671696
Pubmed

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

POLR1A RPS3 NOC3L DDB1 PPP1CC URB1 DIMT1 BYSL UTP20 HDAC1

6.71e-064831191036912080
Pubmed

Cell volume changes regulate slick (Slo2.1), but not slack (Slo2.2) K+ channels.

KCNT2 KCNT1

1.16e-052119225347289
Pubmed

Molecular mechanisms of Slo2 K+ channel closure.

KCNT2 KCNT1

1.16e-052119227682982
Pubmed

O-GlcNAcylation of histone deacetylases 1 in hepatocellular carcinoma promotes cancer progression.

OGT HDAC1

1.16e-052119227060025
Pubmed

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b.

SPPL2B SPPL2A

1.16e-052119216829951
Pubmed

ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease.

LPCAT3 ABHD12

1.16e-052119232364701
Pubmed

PP-1α and PP-1γ display antagonism and differential roles in tumorigenicity of lung cancer cells.

PPP1CA PPP1CC

1.16e-052119223176181
Pubmed

Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons.

KCNT2 KCNT1

1.16e-052119217344399
Pubmed

The intramembrane proteases SPPL2a and SPPL2b regulate the homeostasis of selected SNARE proteins.

SPPL2B SPPL2A

1.16e-052119236047592
Pubmed

Differential distribution of the sodium-activated potassium channels slick and slack in mouse brain.

KCNT2 KCNT1

1.16e-052119226587966
Pubmed

The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo.

SPPL2B SPPL2A

1.16e-052119224492962
Pubmed

Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice.

KCNT2 KCNT1

1.16e-052119230796290
Pubmed

Spermiogenesis is impaired in mice bearing a targeted mutation in the protein phosphatase 1cgamma gene.

PPP1CA PPP1CC

1.16e-05211929882500
Pubmed

Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning.

KCNT2 KCNT1

1.16e-052119226845140
Pubmed

Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis.

SPPL2B SPPL2A

1.16e-052119230819724
Pubmed

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.

MYH10 RPS3 DDB1 PPP1CA URB1 BYSL UTP20 STAG2

2.35e-05340119829478914
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

MYH10 CAND1 SMIM11 UBR4 NOC3L DDB1 PPP1CA PPP1CC ARFGEF3 LONP1 URB1 DIMT1 FDPS LTN1 CTNNA1 STAG2

3.32e-0514401191630833792
Pubmed

CUL4B Promotes Breast Carcinogenesis by Coordinating with Transcriptional Repressor Complexes in Response to Hypoxia Signaling Pathway.

CAND1 OGT DDB1 HDAC1

3.35e-0553119434026424
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

CAND1 OGT ATP13A1 UBR4 CNPPD1 FRY DROSHA KCNQ2 MACF1 CTNNA1 HERC2 WDR13 ABHD12 LGI1 ZNF292

3.41e-0512851191535914814
Pubmed

Function of a membrane-embedded domain evolutionarily multiplied in the GPI lipid anchor pathway proteins PIG-B, PIG-M, PIG-U, PIG-W, PIG-V, and PIG-Z.

PIGB PIGM

3.47e-053119229764287
Pubmed

Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons.

KCNT2 KCNT1

3.47e-053119226559620
Pubmed

Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network.

PPP1CA PPP1CC

3.47e-053119219074462
Pubmed

1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription.

PPP1CA PPP1CC

3.47e-053119225073485
Pubmed

Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.

PPP1CA PPP1CC

3.47e-053119221712997
Pubmed

NOM1 targets protein phosphatase I to the nucleolus.

PPP1CA PPP1CC

3.47e-053119217965019
Pubmed

The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation.

PPP1CA PPP1CC

3.47e-053119212138106
Pubmed

Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization.

PPP1CA PPP1CC

3.47e-05311927857673
Pubmed

Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail.

SPPL2B SPPL2A

3.47e-053119221896273
Pubmed

In vivo measurements of ethanol concentration in rabbit brain by 1H magnetic resonance spectroscopy.

SPPL2B SPPL2A

3.47e-05311922313285
Pubmed

Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells.

PPP1CA PPP1CC

3.47e-053119211739654
Pubmed

Myr 8, a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1.

PPP1CA PPP1CC

3.47e-053119211588169
Pubmed

Characterization of protein phosphatases in mouse oocytes.

PPP1CA PPP1CC

3.47e-05311929882488
Pubmed

Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4DCAF5 ubiquitin ligase.

CAND1 DDB1 HDAC1

3.64e-0519119330442713
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

ICA1 UBR4 FAM20C FRY URB1 ARHGEF33 DROSHA UTP20 RXFP1 HDAC1 PIGM

4.71e-057361191129676528
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

ATP13A1 POLE UBR4 NOC3L CPD FAM98A DDB1 PPP1CC URB1 WDR11 ASPM BYSL MACF1 CTNNA1 HERC2 ABHD12

4.87e-0514871191633957083
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

CAND1 POLR1A RPS3 DDB1 PPP1CA LONP1 URB1 F11R MACF1 UTP20 CTNNA1 HERC2 STAG2

5.08e-0510241191324711643
Pubmed

Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis.

CAND1 CPD DDB1

5.74e-0522119322902628
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

SELENOS ATP13A1 FAM98A DDB1 URB1 WDR11 LTN1 INTS4 UTP20 HERC2 ABHD12

5.85e-057541191133060197
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

MYH10 LZTR1 NOC3L CPD PPP1CA PPP1CC LONP1 WDR11 LTN1 INTS4 CTNNA1 HERC2 HERC1

6.48e-0510491191327880917
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

MYH10 OGT POLR1A NOC3L DDB1 PPP1CC STAG2 HDAC1

6.64e-05394119827248496
Pubmed

Damaged DNA-binding protein down-regulates epigenetic mark H3K56Ac through histone deacetylase 1 and 2.

DDB1 HDAC1

6.93e-054119226255936
Pubmed

Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling.

PPP1CA PPP1CC

6.93e-054119223499489
Pubmed

Inactivation of CREB mediated gene transcription by HDAC8 bound protein phosphatase.

PPP1CC HDAC1

6.93e-054119219070599
Pubmed

The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor.

RPS3 DDB1

6.93e-054119217620334
Pubmed

Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein.

PPP1CA PPP1CC

6.93e-054119216131488
Pubmed

Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1.

PPP1CA PPP1CC

6.93e-054119210194355
Pubmed

Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex.

PPP1CC HDAC1

6.93e-054119212567184
Pubmed

NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1.

PPP1CA PPP1CC

6.93e-054119210880350
Pubmed

Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis.

PPP1CA PPP1CC

6.93e-054119215226296
Pubmed

DNA damage-binding complex recruits HDAC1 to repress Bcl-2 transcription in human ovarian cancer cells.

DDB1 HDAC1

6.93e-054119224249678
Pubmed

Small molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1.

PPP1CA PPP1CC

6.93e-054119222768081
Pubmed

Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif.

PPP1CA PPP1CC

6.93e-054119210807923
Pubmed

Nuclear protein phosphatase-1 regulates HIV-1 transcription.

PPP1CA PPP1CC

6.93e-054119212788939
Pubmed

Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8.

DROSHA HDAC1

6.93e-054119222222205
Pubmed

Formin homology 2 domain-containing 3 (Fhod3) controls neural plate morphogenesis in mouse cranial neurulation by regulating multidirectional apical constriction.

MYH10 CTNNA1

6.93e-054119230573686
Pubmed

Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function.

TTC29 CFAP70

6.93e-054119237934199
Pubmed

Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx.

PPP1CA PPP1CC

6.93e-054119223277204
Pubmed

The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits.

PPP1CA PPP1CC

6.93e-054119212016225
Pubmed

Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation.

PPP1CA PPP1CC

6.93e-054119212221103
Pubmed

Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.

PPP1CA PPP1CC

6.93e-054119212226088
Pubmed

Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation.

PPP1CA PPP1CC

6.93e-054119217202132
Pubmed

A vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand.

PPP1CA PPP1CC

6.93e-054119212036952
Pubmed

N-CoR controls differentiation of neural stem cells into astrocytes.

PPP1CA PPP1CC

6.93e-054119212410313
Pubmed

ATM regulates ionizing radiation-induced disruption of HDAC1:PP1:Rb complexes.

PPP1CA HDAC1

6.93e-054119217008050
Pubmed

Synphilin-1A is a phosphoprotein phosphatase 1-interacting protein and affects PPP1 sorting to subcellular compartments.

PPP1CA PPP1CC

6.93e-054119224902662
Pubmed

Identification of signal peptide peptidase, a presenilin-type aspartic protease.

SPPL2B SPPL2A

6.93e-054119212077416
Pubmed

A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.

POLR1A RPS3 POLE PPP1CC FDPS LTN1 ASPM WDR13

1.02e-04419119828700943
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

RPS3 PPP1CA PPP1CC LONP1 IL1RAPL2 HERC2 HERC1 HDAC1

1.03e-04420119828065597
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

CAND1 OGT POLR1A RPS3 POLE UBR4 FAM98A DDB1 PPP1CA PPP1CC URB1 DIMT1 WDR11 HDAC1

1.04e-0412571191437317656
Pubmed

Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.

MYH10 POLR1A DDB1 LONP1 CTNNA1 HDAC1

1.12e-04219119631353912
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

MYH10 CAND1 OGT RPS3 FAM98A GRM2 DDB1 PPP1CA PPP1CC LONP1 KCNQ2 MACF1 CTNNA1 ABHD12 LGI1

1.14e-0414311191537142655
Pubmed

Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms.

OGT PPP1CC

1.15e-045119227505673
Pubmed

Distinct roles for the α , β and γ1 isoforms of protein phosphatase 1 in the outside-in αIIbβ3 integrin signalling-dependent functions.

PPP1CA PPP1CC

1.15e-045119223197154
Pubmed

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins.

SPPL2B SPPL2A

1.15e-045119215385547
Pubmed

Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions.

PPP1CA PPP1CC

1.15e-045119219581931
Pubmed

Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability.

UBE2Q1 HERC2

1.15e-045119222124266
Pubmed

Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores.

PPP1CA PPP1CC

1.15e-045119222801782
Pubmed

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production.

SPPL2B SPPL2A

1.15e-045119216829952
Pubmed

The heterotrimeric G protein Gβ1 interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein-coupled receptor signaling in platelets.

PPP1CA PPP1CC

1.15e-045119228615442
Pubmed

Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220.

PPP1CA PPP1CC

1.15e-045119210209101
Pubmed

A PP1-PP2A phosphatase relay controls mitotic progression.

PPP1CA PPP1CC

1.15e-045119225487150
Pubmed

CCDC6 represses CREB1 activity by recruiting histone deacetylase 1 and protein phosphatase 1.

PPP1CA HDAC1

1.15e-045119220498639
Pubmed

Ubiquitination of stalled ribosome triggers ribosome-associated quality control.

RPS3 LTN1

1.15e-045119228757607
Pubmed

Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases.

PPP1CC HDAC1

1.15e-045119214670976
Pubmed

SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1.

PPP1CA PPP1CC

1.15e-045119220424263
Pubmed

Novel class of polytopic proteins with domains associated with putative protease activity.

SPPL2B SPPL2A

1.15e-045119212139484
InteractionCDH5 interactions

POLR1A ATP13A1 F2RL2 ASPM TIGD5 CTNNA1 RBFA

2.69e-061091137int:CDH5
InteractionSIRT7 interactions

MYH10 POLR1A POLE UBR4 NOC3L DDB1 PPP1CA PPP1CC LONP1 URB1 BYSL MACF1 UTP20 CTNNA1 HERC2 STAG2

3.99e-0674411316int:SIRT7
InteractionBRWD3 interactions

DDB1 LLGL2 WDR11 MACF1 WDR13

8.78e-06501135int:BRWD3
InteractionHECTD1 interactions

MYH10 CAND1 POLR1A RPS3 POLE NOC3L FAM98A DDB1 URB1 DIMT1 DROSHA ASPM BYSL MACF1 UTP20 HERC2 MED23 HDAC1

8.91e-0698411318int:HECTD1
InteractionKIR2DL4 interactions

ATP13A1 SPPL2A FCER1G LTN1 INTS4 STAG2

1.48e-05941136int:KIR2DL4
InteractionTOP3B interactions

MYH10 LZTR1 ITPRIPL2 ATP13A1 POLE UBR4 TMC6 PANX1 SPPL2B CNPPD1 FAM20C LONP1 URB1 LLGL2 BYSL LRP3 KCNQ2 ULK4 HERC2 HERC1 PLXNA1 ABCC10

1.94e-05147011322int:TOP3B
InteractionGPR17 interactions

MMS22L UBE2Q1 ARFGEF3 URB1 LPCAT3 LTN1 UTP20 MED23 STAG2

3.12e-052831139int:GPR17
InteractionRPS24 interactions

CAND1 OGT RPS3 NOC3L CCDC168 PPP1CA PPP1CC URB1 BYSL UTP20 CTNNA1 HERC2

4.21e-0552911312int:RPS24
InteractionTTYH1 interactions

ITPRIPL2 HTR6 TMC6 SPPL2B KCNT2 LPCAT3 ABHD12 ABCC10 PIGM

4.91e-053001139int:TTYH1
InteractionCIT interactions

MYH10 POLR1A RPS3 UBR4 NOC3L FAM98A GRM2 DDB1 PPP1CA PPP1CC LONP1 URB1 DIMT1 BYSL INTS4 MACF1 UTP20 CTNNA1 HERC1 STAG2 HDAC1

5.00e-05145011321int:CIT
InteractionHSPA13 interactions

CAND1 OGT UBR4 FAM20C FRY CTNNA1

6.48e-051221136int:HSPA13
InteractionLUC7L3 interactions

CAND1 OGT GRM2 DDB1 PPP1CC HERC2 HDAC1

8.35e-051851137int:LUC7L3
InteractionCBARP interactions

ATP13A1 TMC6 PORCN PPP1CA PPP1CC

8.72e-05801135int:CBARP
InteractionPPP1R15B interactions

PTGER3 PPP1CA PPP1CC LRP3 RXFP1

9.81e-05821135int:PPP1R15B
GeneFamilyPotassium sodium-activated channel subfamily T

KCNT2 KCNT1

1.93e-052802856
GeneFamilyTransmembrane channel likes

TMC7 TMC6

5.32e-0488021135
GeneFamilyDolichyl D-mannosyl phosphate dependent mannosyltransferases|Phosphatidylinositol glycan anchor biosynthesis

PIGB PIGM

6.82e-049802430
GeneFamilyProtein phosphatase catalytic subunits|EF-hand domain containing

PPP1CA PPP1CC

1.46e-0313802693
GeneFamilyCD molecules|I-set domain containing|Immunoglobulin like domain containing|Interleukin receptors|TIR domain containing

IL1RAPL2 SIGIRR

1.96e-03158021296
CoexpressionGSE21670_STAT3_KO_VS_WT_CD4_TCELL_DN

CYSLTR2 POLR1A NOC3L FAM98A LINS1 LPCAT3 BYSL UTP20

3.66e-061991198M7454
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Nefl_(Neurofilament_state)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ADCY10 MGAT4D CCDC168 ASPM

6.97e-0646119437ea73d291e35b6865bd3ea4857275a6e5b299d1
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Nefl_(Neurofilament_state)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ADCY10 MGAT4D CCDC168 ASPM

6.97e-0646119469e9c8cbae3d15bd0823b8c6e48a9d2b9815296b
ToppCellPCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ICA1 FRMPD2 ARFGEF3 FRY LLGL2 ATP11A

1.02e-051841196fa4915b0498f3069fd5ef497286445528f75187e
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

UNC13D LLGL2 KCNT2 ATOH8 ATP11A PLXNA1

1.42e-05195119668f4cc84b5ae7f4159b780c78e4b66c94211779a
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

UNC13D LLGL2 KCNT2 ATOH8 ATP11A PLXNA1

1.42e-0519511962a1863f4b9fe73c30b0b1acf9b12fc98ef65040f
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

UNC13D LLGL2 KCNT2 ATOH8 ATP11A PLXNA1

1.46e-051961196eb68f7954e7c2f86d05e740e95b6e74805a6053f
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuroepithelial|5w / Sample Type, Dataset, Time_group, and Cell type.

WAS RPS3 TMC6 UNC13D COLEC12 HAS2

1.64e-05200119669707f9576d326a06faac49701ef5cd632e760f6
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuroepithelial-Proteoglycan-expressing_cell|5w / Sample Type, Dataset, Time_group, and Cell type.

WAS RPS3 TMC6 UNC13D COLEC12 HAS2

1.64e-052001196f94381d0a3b5b81cdbb13b75fc0e4910cbd70382
ToppCell368C-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TSPAN12 POLE ICA1 FRY RXFP1

6.24e-0515611954877aabf647238c0279e497345b6a6d5ee07ef9c
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

OGT NEK10 TTC29 CYP4X1 CFAP70

6.24e-05156119510d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell368C-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TSPAN12 POLE ICA1 FRY RXFP1

6.24e-0515611951d681fa17e62815f5d5f90c86be3c248b38e011b
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC190 UNC13D CA14 LLGL2 ATOH8

6.43e-0515711959665a1375cfd8e9b8781c852686591226c0e0d9a
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_2|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

ITPRIPL2 POLR1A POLE PANX1 LTN1

9.11e-051691195ea600c63cf9572bc4b3cad6392f67bd0d92c7fc9
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MMS22L MYH10 PTGER3 COLEC12 MACF1

1.10e-041761195d30241fb8119834d6e7b59efec3f92fc7a3d1247
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.16e-041781195de5d50d7ca9ee9eb62f50c88a0c6d47f0694b2e6
ToppCellRSV-Healthy-0|RSV / Virus stimulation, Condition and Cluster

ICA1 PPP1CA LLGL2 WDR11 INTS4

1.22e-041801195974044056e2f7e909cb11c6f6ca89e58bf95f7e5
ToppCellRSV-Healthy-0|Healthy / Virus stimulation, Condition and Cluster

ICA1 PPP1CA LLGL2 WDR11 INTS4

1.22e-041801195703a1d0f9536af94d56757eb01221878d7b7fe61
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NEK10 FRMPD2 TTC29 CFAP70 CCDC157

1.26e-041811195dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.29e-041821195fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.39e-0418511953e39a3cb534dfe2301930f3e2f7e8cefb522c158
ToppCelldroplet-Bladder-BLADDER-1m-Hematologic-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYSLTR2 WAS UNC13D F2RL2 FCER1G

1.39e-041851195969248b63d4ce335f223528de756bcddffadbd77
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.39e-04185119518a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK-T_mait-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

POLR1A WDR11 LTN1 ABHD12 ABCC10

1.43e-041861195927723ad579bbd9947ff525bd501e222d3fa9289
ToppCell21-Trachea-Epithelial-Intermediate_ciliated|Trachea / Age, Tissue, Lineage and Cell class

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.46e-0418711951a2178a195d078d1963947b327c6d0d4f2f48341
ToppCellAdult-Epithelial-ciliated_cell-D231|Adult / Lineage, Cell type, age group and donor

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.50e-04188119534b11f72ca73153d02edcd09b38983ad1a504659
ToppCellPCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ICA1 ARFGEF3 FRY LLGL2 IL1RAPL2

1.50e-0418811950d86044bc340e3efb90d0022dd299873639d831c
ToppCellCiliated_cells-B-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.50e-041881195606907c865bd2f11bb6474932716550f7723d858
ToppCellPCW_10-12-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ICA1 ARFGEF3 FRY LLGL2 IL1RAPL2

1.50e-041881195beb2df2332a46cc81b10e8e29fc9829020111f03
ToppCellCOVID-19-lung-Ciliated|COVID-19 / Disease (COVID-19 only), tissue and cell type

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.54e-041891195a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.54e-04189119568a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCellControl-Epithelial-Ciliated|Control / Disease state, Lineage and Cell class

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.54e-041891195c007fccd08728db3ea99af9da91d67b9b16dabb3
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ICA1 PTGER3 SPPL2A IL1RAPL2 DIO2

1.54e-041891195977a813e5d7a5a561c1fced2bbf21c20056b88d8
ToppCellCOPD-Epithelial-ATI|Epithelial / Disease state, Lineage and Cell class

TSPAN12 UNC13D KCNT2 ATOH8 PLXNA1

1.54e-04189119514e8e57e4db336fbef005270647983b4edf407c0
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NEK10 CCDC190 TTC29 CFAP70 CCDC157

1.54e-041891195b4b93bd10b7e3cc16e54ff73beac230f519c010a
ToppCellAdult-Epithelial-ciliated_cell|Adult / Lineage, Cell type, age group and donor

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.54e-041891195b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCellCOVID-19-lung-Ciliated|lung / Disease (COVID-19 only), tissue and cell type

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.54e-04189119527329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCellCOPD-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

NEK10 FRMPD2 TTC29 ULK4 CFAP70

1.54e-0418911953e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCelldroplet-Limb_Muscle-nan-21m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN12 F11R SIGIRR CTNNA1 B4GALT4

1.58e-0419011951ff2295c9fc94ea21fff286706b739d0deb032d0
ToppCelldroplet-Limb_Muscle-nan-21m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN12 F11R SIGIRR CTNNA1 B4GALT4

1.58e-04190119561f2f9fb4b8f47a2a669f6b052214d2ce0c194cd
ToppCelldroplet-Limb_Muscle-nan-21m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN12 F11R SIGIRR CTNNA1 B4GALT4

1.58e-041901195d415c8f3d69a8142e95307aeabc6d0e812cd5165
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_intermediate_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ICA1 ARFGEF3 FRY LLGL2 F11R

1.62e-04191119572dbd2e0fabfca8d6f604df35277d3574739a0b3
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

NEK10 ICA1 ARFGEF3 FRY CFAP70

1.62e-04191119560ff989fe99d243a3d52955223680cdd1f1917a4
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.62e-041911195e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.62e-0419111959d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCellwk_15-18-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.62e-041911195e81cd65dbf0ef1c2ab7088f73ce605d456dd3a7a
ToppCellnucseq-Epithelial-Epithelial_Airway|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.62e-0419111951c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCellmulticiliated|World / shred by cell class for turbinate

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.65e-0419211950f89ea0deb651ca11531c51ee94e0233608d22ea
ToppCellIPF-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.65e-041921195d903bbd6c18e29e2c4cdedeb3fea1fd5ad7baa11
ToppCellCOPD-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.65e-041921195eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCellCOPD-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

MYH10 F11R ULK4 MACF1 HAS2

1.65e-04192119562904f94dfce430456f05066522cbf9bd29f4d7e
ToppCellPCW_10-12-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

NEK10 ICA1 ARFGEF3 FRY IL1RAPL2

1.70e-041931195b25cdca3a1e381784ae48ca73c51cbb6ac62b811
ToppCellControl-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

NEK10 FRMPD2 TTC29 ULK4 CFAP70

1.70e-0419311950e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

CAND1 CPD ARFGEF3 MED23 STAG2

1.70e-041931195abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCellfacs-Large_Intestine-Distal-24m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN12 ICA1 CPD B3GNT7 TMCO3

1.70e-0419311955a92697430f16c49e19a5f727d289d7bd1ece31c
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

NEK10 FRMPD2 TTC29 ULK4 CFAP70

1.70e-041931195ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCellfacs-Large_Intestine-Distal-24m-Epithelial-secretory_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TSPAN12 ICA1 CPD B3GNT7 TMCO3

1.70e-04193119564bcdbb422f8da6fc3275e82f6aaf562f546a180
ToppCellPCW_05-06-Epithelial-Epithelial_airway|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ICA1 ARFGEF3 FRY LLGL2 F11R

1.70e-041931195af6ec2c2ba92aef3e41531c3c7215b3300437bd9
ToppCellwk_20-22-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.74e-041941195756082a0f5953b52229bb60d40b84701cb6cb23d
ToppCellNS-critical-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.74e-0419411951ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCellPCW_13-14-Epithelial-Epithelial_airway|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ICA1 ARFGEF3 FRY LLGL2 IL1RAPL2

1.74e-0419411957b2b40a56eb9c7203ca50133b2da4fd8fdd4a5cf
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ICA1 ARFGEF3 FRY LLGL2 F11R

1.74e-041941195b19e16a76d7342ff9a665d19c9151652916f17d4
ToppCellPCW_05-06-Epithelial|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ICA1 ARFGEF3 FRY LLGL2 F11R

1.74e-04194119547a1369c22fcbfe00b08376eb610a61c355548db
ToppCellCOVID-19-Epithelial-Ciliated_cells|COVID-19 / Condition, Lineage and Cell class

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.74e-04194119543be5fbd51dd58839cb03ca3ddd05a458e1ddb74
ToppCellIPF-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

NEK10 FRMPD2 ARFGEF3 TTC29 CFAP70

1.78e-04195119521dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCelldroplet-Lung-21m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_endothelial_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TSPAN12 CA14 F11R CTNNA1 B4GALT4

1.78e-04195119527d1f228103ff5d8941aa8a8d15726cd09298a30
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

OGT ICA1 PTGER3 SPPL2A DIO2

1.78e-041951195a38d9dc6192aea673d96fda6b25e81223fda3abf
ToppCellmoderate-Epithelial-Ciliated|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.78e-041951195e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCellSecretory|World / shred by cell class for bronchial biopsy

CCDC190 ARFGEF3 FDPS TMCO3 B4GALT4

1.78e-04195119552f8281fe0df67cec3faa780a23ed6343ed5a6ba
ToppCellcritical-Epithelial-Ciliated|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.82e-04196119527b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCellBAL-Severe-Epithelial-Epithelial-Ciliated|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.82e-041961195686a5a0ddb00929842c1c98445c59edfcc9a8a04
ToppCellBAL-Severe-Epithelial-Epithelial-Ciliated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.82e-04196119567aefc480714e4b8c9ae53c036efdc07ec6f94af
ToppCellBAL-Severe-Epithelial-Epithelial-Ciliated|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.82e-041961195ca56311edc6788e032e7635fa69b1e07035202b5
ToppCellSevere_COVID-19-Epithelial-Ciliated|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.82e-0419611951cdef976a754c90d18b6149d367bd64e6e99b0a9
ToppCellNS-control-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.82e-041961195d46ab80554dd3c1cc81e1938ea2acfd5e85c6d2a
ToppCellBAL-Severe-Epithelial-Epithelial-Ciliated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.82e-04196119569f5081e06d84ec1d9695762df801a9d0df1984b
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

OGT MACF1 HERC1 MED23 ZNF292

1.86e-04197119557ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellNS-moderate-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.86e-04197119571fea4aa6ce96c7693fa94792d08770622873850
ToppCell(5)_Fibroblasts-(5)_Fibroblast-G|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

MYH10 MEI1 F11R ULK4 MACF1

1.86e-041971195a21a710c824f9e5c7ef1674168d1ce5aef85bd35
ToppCellcritical-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

1.91e-041981195ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCellControl_saline-Epithelial_alveolar-AT_1-Differentiating_AT1|Control_saline / Treatment groups by lineage, cell group, cell type

UNC13D LLGL2 ATOH8 ATP11A PLXNA1

1.91e-04198119585f424cd9bb3117c9e322031024aabb87696ce47
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-innate_lymphocytic|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

B3GNT7 LLGL2 SIGIRR MACF1 B4GALT4

1.91e-041981195326e97bdc27cc3440f5488c2519446580cdc9d51
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

B3GNT7 LLGL2 SIGIRR MACF1 B4GALT4

1.91e-0419811952fdb92b198ba24e326e90479fd024400d956fb32
ToppCellLPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

UNC13D LLGL2 ATOH8 CYP4X1 PLXNA1

1.91e-041981195b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

UNC13D LLGL2 ATOH8 ATP11A PLXNA1

1.95e-041991195d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MYH10 COLEC12 LRP3 MACF1 HAS2

1.95e-041991195a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

2.00e-04200119552aef65f01b06cd98056f17977efe525aee6eb6f
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

2.00e-04200119555c148238d5c80c1faa3428a917ae8075be2c145
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / Treatment groups by lineage, cell group, cell type

UNC13D LLGL2 ATOH8 ATP11A PLXNA1

2.00e-0420011952dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

2.00e-04200119585c98da55f7cd4ffdf9d309b56c8cc5d43f3c04c
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

UNC13D LLGL2 ATOH8 ATP11A PLXNA1

2.00e-042001195ddfb1f006365bf16203ee49f20200f68220cc288
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_airway_ciliated|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

2.00e-0420011957cb3e3bd9e851ccb096e0a3471819471d85ebace
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MYH10 COLEC12 LRP3 MACF1 HAS2

2.00e-0420011953bdba9612cd7c612b76aa9abecc4a6529aabfc1c
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

2.00e-042001195e1dce91c6c531bb212002a14705e496d77ad3490
ToppCellBrain_organoid-organoid_Tanaka_cellReport-1m-Mesenchymal-Mesoderm|1m / Sample Type, Dataset, Time_group, and Cell type.

TMC7 UNC13D GPR137C HERC1 MED23

2.00e-042001195c0ad32e9dd7f481c2665587fd8bd9fffc2e725f9
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

2.00e-04200119512bc7d95c4166d12487081a76d210b7abe5991b0
ToppCell18-Distal-Epithelial-Bud_tip_adjacent|Distal / Age, Tissue, Lineage and Cell class

TSPAN12 RPS3 ICA1 UNC13D ATP11A

2.00e-0420011953c231d0a5809eab0acd6d0a77d54c49ac3eaaff3
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_airway_ciliated-Ciliated|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

NEK10 FRMPD2 CCDC190 TTC29 CFAP70

2.00e-0420011958441e289377215a6877640946fe3f6de1f456502
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Deptor_(Deep_layer_pyramidal_cells--Layer_5a)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

MEI1 GRM2 F2RL2 IL1RAPL2

2.02e-041081194514dfc3f7ac303311ae599f981f3f3c7eb6801b8
Diseasecancer (implicated_via_orthology)

TSPAN12 CAND1 POLE PPP1CA PPP1CC LLGL2 MACF1

7.59e-052681127DOID:162 (implicated_via_orthology)
DiseaseHematopoetic Myelodysplasia

CTNNA1 STAG2 HDAC1

1.81e-04291123C2713368
Diseaseglucagon measurement, glucose tolerance test

MACF1 HERC1

2.12e-0461122EFO_0004307, EFO_0008463
DiseaseDrug Allergy

CYSLTR2 PTGER3 FCER1G

3.19e-04351123C0013182
Diseasekidney cancer (implicated_via_orthology)

POLE LLGL2

7.68e-04111122DOID:263 (implicated_via_orthology)
Diseasesystolic blood pressure, cigarettes per day measurement

FRY DIO2

1.08e-03131122EFO_0006335, EFO_0006525
DiseaseSeizures

PIGB KCNQ2 MACF1 ZNF292 PIGM

1.49e-032181125C0036572
DiseaseIntellectual Disability

PIGB LINS1 FRY MACF1 MED23 STAG2 ZNF292

1.62e-034471127C3714756
DiseasePsychoses, Substance-Induced

HTR6 GRM2

1.87e-03171122C0033941
DiseaseVertigo

TSPAN12 SPPL2A DROSHA ABCC10

1.98e-031391124HP_0002321
Diseaseascending aortic diameter

NOC3L UNC13D ULK4 HAS2

2.03e-031401124EFO_0021787
DiseaseMYELODYSPLASTIC SYNDROME

CTNNA1 STAG2 HDAC1

2.14e-03671123C3463824
Diseasepulse pressure measurement, alcohol drinking

NEK10 ULK4 ABCC10

2.42e-03701123EFO_0004329, EFO_0005763
DiseasePsychoses, Drug

HTR6 GRM2

2.86e-03211122C0033937
Diseasenucleus accumbens volume change measurement, age at assessment

CCDC190 B3GNT7

3.14e-03221122EFO_0008007, EFO_0021493
Diseasecomplement factor H-like 1 protein measurement

KCNT2 KCNQ2

3.14e-03221122EFO_0600092
Diseasemean reticulocyte volume

POLR1A TMC6 NOC3L PPP1CA LONP1 INTS4 TMCO3 STAG2 ABCC10

3.45e-037991129EFO_0010701

Protein segments in the cluster

PeptideGeneStartEntry
YLRVVLLCALKLYVN

CAPZA3

116

Q96KX2
NLCLISLDRYLLILS

HTR6

116

P50406
YKFRLLLLLTLCLTV

B4GALT4

11

O60513
SRNRYKLFLECTLIL

ATP13A1

471

Q9HD20
VLLIALCTLYAFKTR

GRM2

736

Q14416
YLLLVCVQRLRVFIS

ARHGEF33

421

A8MVX0
RLAQLYRQTVCLSLL

ADCY10

1201

Q96PN6
IDRLLLLLQSCMSYL

CCDC157

81

Q569K6
LLLVCFLDYAKISRL

ASPM

891

Q8IZT6
LNGLLYKALTDLLCT

RBFA

96

Q8N0V3
ATYLRCQLLLIKALQ

INTS4

661

Q96HW7
FYRVVTCSLLALKRL

LTN1

221

O94822
RLRKILFCVLGLYIA

ABHD12

71

Q8N2K0
LSKLAILRIACNYIL

ATOH8

266

Q96SQ7
ILRIACNYILSLARL

ATOH8

271

Q96SQ7
RLCLLILQLAALLAY

ABCC10

171

Q5T3U5
LTSLLALKLLQYCLA

SLC46A1

316

Q96NT5
NCLFLALYDSVILLK

DIO2

21

Q92813
ALLCARVVDYLTKLN

NT5DC1

136

Q5TFE4
CLALLLYFQLREKIT

LINS1

151

Q8NG48
YKLALSFQLCRLEQL

LZTR1

551

Q8N653
CLRLLYKLSTVRVFL

LLGL2

456

Q6P1M3
CYVNDIVLAILELLK

HDAC1

151

Q13547
VDLDLLRCQQLKLYI

HERC2

2311

O95714
LRCQQLKLYILKAGR

HERC2

2316

O95714
SYLCSGALKRLILNL

MMS22L

46

Q6ZRQ5
NDANLLEACIYRLLK

FDPS

196

P14324
LLNLYLAEVICKVRC

GPR137C

141

Q8N3F9
YKVRSRLLACKNLEL

HERC1

1301

Q15751
FSLKLLTCLLYIVRV

KCNT1

101

Q5JUK3
ACYLVRILFSKEILI

BEND2

506

Q8NDZ0
RLQRLKVICLYHVKL

CCDC190

31

Q86UF4
SNLKIDALSCLYVIL

CAND1

491

Q86VP6
KIYCLLSVRNVKALA

EFCAB9

16

A8MZ26
KLLLLDYAANRLLAC

PLXNA1

116

Q9UIW2
YSDLKRLRCLLNVQS

NEK10

26

Q6ZWH5
LCLILASFLVYLAEK

KCNQ2

241

O43526
YLLLRKILLRKFCQI

PTGER3

346

P43115
LKFSIILLYILCALL

COLEC12

36

Q5KU26
GIVLTLLYCRLKIQV

FCER1G

36

P30273
LLYCRLKIQVRKAAI

FCER1G

41

P30273
KYNIVTLDRLILCLA

MED23

856

Q9ULK4
QCYRRLLKALKTARL

LCT

111

P09848
LLVIALGCAFKLYSL

LRP3

511

O75074
YHSLLCIVLQFLILR

LPCAT3

91

Q6P1A2
LSSDVLTLLIKQYCR

LONP1

691

P36776
YASLLLVLALLLRLC

GDPD2

96

Q9HCC8
LKTICRAIQRFLLAY

POLE

1561

Q07864
NFSLKLLSCLLYIIR

KCNT2

66

Q6UVM3
LLSCLLYIIRVLLEN

KCNT2

71

Q6UVM3
LLLVSCVVILYSLKT

OR4C13

211

Q8NGP0
ISYCLIAQAVLKIRS

OR2C1

216

O95371
SNNLIIKYISCRLLT

PANX1

206

Q96RD7
IKYISCRLLTLIIIL

PANX1

211

Q96RD7
VSRRLCLLLVSLTYL

OR8J3

136

Q8NGG0
LVTLRLECTNLYRKG

MACF1

516

Q9UPN3
RIKQVLDFCILLLYA

MGAT4D

231

A6NG13
INCLGLLRQLLKYDL

MEI1

241

Q5TIA1
ILLLACISINRYLAI

F2RL2

181

O00254
RGKQSLETICLLLAY

PPP1CA

96

P62136
QKVARSLALALLCLV

PORCN

191

Q9H237
VSRRLCLLLVSLTYL

OR8J1

136

Q8NGP2
QRLVKLSCLLAVAYV

CNPPD1

226

Q9BV87
ACKQDLLAYLQRIAL

CTNNA1

771

P35221
CRIRKSTYLRLQLLA

FAM20C

501

Q8IXL6
AYLALVCLKVGRQLE

CFAP70

1071

Q5T0N1
KSYLALRDLCVVLLN

FRMPD2

336

Q68DX3
ALDYLRRCSQLLAKI

ARFGEF3

1391

Q5TH69
CLALGLLQAIKLYLR

CYP4X1

21

Q8N118
LLTLYVVLINKCGRR

HAS2

526

Q92819
CYQLINLSILLKRLF

C1orf112

491

Q9NSG2
RELLLNLIEYLCKNF

CPD

571

O75976
ALLISCIAYLLVTRN

CEACAM19

171

Q7Z692
ELCQRLYKLHFQLLL

FRY

2826

Q5TBA9
IDKLLYNTAARCILS

CCDC168

2221

Q8NDH2
KTVYRSLCLALALLV

B3GNT7

6

Q8NFL0
CLCLLLAVYFIARKI

CA14

301

Q9ULX7
LLAARKYQEALQLCL

IFT140

1146

Q96RY7
CLLTLVQRYKADLAT

BYSL

381

Q13895
LLFILTAKYNACILE

DDB1

76

Q16531
LKVLQRNCAAYLKLR

MYH10

816

P35580
LYCRLSINTQLLARV

DIMT1

171

Q9UNQ2
LYCVRSDLGNLLKAL

OGT

156

O15294
QRALAFIKRLCTLAL

NOC3L

621

Q8WTT2
IQRTCLDLSKAIVLY

ICA1

66

Q05084
QVERKLLCLFILAIL

F11R

6

Q9Y624
CYLKCLQLLKALRDL

ITPRIPL2

371

Q3MIP1
ITSYVLILCSQRKAL

OR4C5

236

Q8NGB2
IYLLLFTIALRILNC

PIGB

61

Q92521
LLLCGTISLRVYRKV

RTN2

386

O75298
LISAYLPKILQILLC

UTP20

1111

O75691
QILLYLLRCSKALVP

DROSHA

701

Q9NRR4
KVLTCLARLFTAYLQ

POLR1A

776

O95602
TLSLALCVRILNIYL

SLC9B1P1

171

A6NJY1
SLAAVFLLCLVIKKY

TMCO3

466

Q6UWJ1
RLLIQKNCLLLLTYL

FAM98A

101

Q8NCA5
LLLVLLVVIYKCYNI

IL1RAPL2

366

Q9NP60
ALLLAALLYVKCRLN

SIGIRR

131

Q6IA17
LCAIAQAESLRYKLL

RPS3

96

P23396
SLLINACLNKLLLYR

WDR13

371

Q9H1Z4
LDLLRCQQLKLYILK

HERC2P3

1026

Q9BVR0
TILLKAVLLQVICLY

URB1

551

O60287
TLSICYLLIIRVLLK

CYSLTR2

216

Q9NS75
FLIVYLCILISKALI

ATP11A

296

P98196
CILLYVVFQKLSARL

SELENOS

41

Q9BQE4
RRNLLAAFCKLIVYT

STAG2

861

Q8N3U4
NFKSCVILLGLLLLY

SPPL2A

336

Q8TCT8
KACTLLLLVLFLYDI

SPPL2B

346

Q8TCT7
QVYLERCRQLSLLTK

ZNF292

311

O60281
RKCLTLATAVVQLYL

WAS

41

P42768
LLLTFLTLEKYICIV

RXFP1

501

Q9HBX9
SVKCLRCLLYALNLL

TSPAN12

6

O95859
RGKQSLETICLLLAY

PPP1CC

96

P36873
LLLYILAAKTLILCL

SMIM11

11

P58511
NLLACESLLRTYRLL

TTC29

226

Q8NA56
VYVAICRNLILKLAI

TMC6

506

Q7Z403
LYQRNLCLHLKAEAL

TTC37

346

Q6PGP7
KQLYKRELLRLAVSC

TIGD5

426

Q53EQ6
EFTLLQRCLLVSRLY

WDR11

906

Q9BZH6
VLNGYLCLRKLVVQR

UBR4

4266

Q5T4S7
YELLKRLCNRAVLLF

PIGM

216

Q9H3S5
LFQLYISLKELCQLR

UNC13D

556

Q70J99
IRIYSLRLFLNCIVL

TMC7

356

Q7Z402
LQHLKRIISDLCKLY

UBE2Q1

146

Q7Z7E8
TCIRAKAFLVLLYIL

ULK4

746

Q96C45
LKRIAYFLCLLSALL

LGI1

16

O95970