Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	MAN2A2 MAN2A1	1.79e-05	2	85	2	GO:0004572
GeneOntologyMolecularFunction	1-phosphatidylinositol-5-phosphate 4-kinase activity	PIP4K2A PIP4K2B	5.36e-05	3	85	2	GO:0016309
Domain	-	MAN2A2 MAN2A1	2.13e-04	5	87	2	1.20.1270.50
Domain	-	MAN2A2 MAN2A1	2.13e-04	5	87	2	3.20.110.10
Domain	Glyco_hydro_38_C	MAN2A2 MAN2A1	2.13e-04	5	87	2	IPR011682
Domain	Alpha-mann_mid	MAN2A2 MAN2A1	2.13e-04	5	87	2	SM00872
Domain	Alpha-mann_mid	MAN2A2 MAN2A1	2.13e-04	5	87	2	PF09261
Domain	Glyco_hydro_38_N	MAN2A2 MAN2A1	2.13e-04	5	87	2	IPR000602
Domain	Glyco_hydro_38/57_N	MAN2A2 MAN2A1	2.13e-04	5	87	2	IPR027291
Domain	Glyco_hydro_38_cen	MAN2A2 MAN2A1	2.13e-04	5	87	2	IPR015341
Domain	Glyco_hydro_57/38_cen	MAN2A2 MAN2A1	2.13e-04	5	87	2	IPR028995
Domain	Glyco_hydro_38C	MAN2A2 MAN2A1	2.13e-04	5	87	2	PF07748
Domain	Glyco_hydro_38	MAN2A2 MAN2A1	2.13e-04	5	87	2	PF01074
Domain	HOOK	CCDC88C CCDC88B	3.18e-04	6	87	2	PF05622
Domain	Hook-related_fam	CCDC88C CCDC88B	3.18e-04	6	87	2	IPR008636
Domain	DEAD/DEAH_box_helicase_dom	RECQL4 DDX60L DDX21 DDX39A	3.74e-04	73	87	4	IPR011545
Domain	DEAD	RECQL4 DDX60L DDX21 DDX39A	3.74e-04	73	87	4	PF00270
Domain	Glyco_hydro/deAcase_b/a-brl	MAN2A2 MAN2A1	4.44e-04	7	87	2	IPR011330
Domain	PInositol-4-P-5-kinase	PIP4K2A PIP4K2B	4.44e-04	7	87	2	IPR023610
Domain	PIPKc	PIP4K2A PIP4K2B	5.90e-04	8	87	2	SM00330
Domain	-	PIP4K2A PIP4K2B	5.90e-04	8	87	2	3.30.800.10
Domain	PIP5K	PIP4K2A PIP4K2B	5.90e-04	8	87	2	PF01504
Domain	PIPK	PIP4K2A PIP4K2B	5.90e-04	8	87	2	PS51455
Domain	PInositol-4-P-5-kinase_N	PIP4K2A PIP4K2B	5.90e-04	8	87	2	IPR027484
Domain	PInositol-4-P-5-kinase_C	PIP4K2A PIP4K2B	5.90e-04	8	87	2	IPR027483
Domain	-	PIP4K2A PIP4K2B	5.90e-04	8	87	2	3.30.810.10
Domain	PInositol-4-P-5-kinase_core	PIP4K2A PIP4K2B	5.90e-04	8	87	2	IPR002498
Domain	Helicase_C	RECQL4 DDX60L DDX21 DDX39A	1.57e-03	107	87	4	PF00271
Domain	HELICc	RECQL4 DDX60L DDX21 DDX39A	1.57e-03	107	87	4	SM00490
Domain	Helicase_C	RECQL4 DDX60L DDX21 DDX39A	1.63e-03	108	87	4	IPR001650
Domain	HELICASE_CTER	RECQL4 DDX60L DDX21 DDX39A	1.68e-03	109	87	4	PS51194
Domain	HELICASE_ATP_BIND_1	RECQL4 DDX60L DDX21 DDX39A	1.68e-03	109	87	4	PS51192
Domain	DEXDc	RECQL4 DDX60L DDX21 DDX39A	1.68e-03	109	87	4	SM00487
Domain	Helicase_ATP-bd	RECQL4 DDX60L DDX21 DDX39A	1.74e-03	110	87	4	IPR014001
Domain	-	MAN2A2 MAN2A1	1.88e-03	14	87	2	2.60.40.1180
Domain	uDENN	DENND2A DENND2D	1.88e-03	14	87	2	SM00800
Domain	CNH	MINK1 MAP4K4	1.88e-03	14	87	2	SM00036
Domain	Glyco_hydro_b	MAN2A2 MAN2A1	2.17e-03	15	87	2	IPR013780
Domain	CNH	MINK1 MAP4K4	2.17e-03	15	87	2	PF00780
Domain	uDENN	DENND2A DENND2D	2.17e-03	15	87	2	PF03456
Domain	CNH	MINK1 MAP4K4	2.17e-03	15	87	2	PS50219
Domain	CNH_dom	MINK1 MAP4K4	2.17e-03	15	87	2	IPR001180
Domain	UDENN	DENND2A DENND2D	2.47e-03	16	87	2	PS50946
Domain	DDENN	DENND2A DENND2D	2.47e-03	16	87	2	PS50947
Domain	DENN	DENND2A DENND2D	2.47e-03	16	87	2	SM00799
Domain	Laminin_N	LAMB3 USH2A	2.47e-03	16	87	2	IPR008211
Domain	dDENN	DENND2A DENND2D	2.47e-03	16	87	2	SM00801
Domain	DENN	DENND2A DENND2D	2.47e-03	16	87	2	PF02141
Domain	LAMININ_NTER	LAMB3 USH2A	2.47e-03	16	87	2	PS51117
Domain	dDENN_dom	DENND2A DENND2D	2.47e-03	16	87	2	IPR005112
Domain	uDENN_dom	DENND2A DENND2D	2.47e-03	16	87	2	IPR005113
Domain	Laminin_N	LAMB3 USH2A	2.47e-03	16	87	2	PF00055
Domain	dDENN	DENND2A DENND2D	2.47e-03	16	87	2	PF03455
Domain	DENN	DENND2A DENND2D	2.47e-03	16	87	2	PS50211
Domain	DENN_dom	DENND2A DENND2D	2.47e-03	16	87	2	IPR001194
Domain	LamNT	LAMB3 USH2A	2.47e-03	16	87	2	SM00136
Domain	Gal_mutarotase_SF_dom	MAN2A2 MAN2A1	2.79e-03	17	87	2	IPR011013
Domain	C2	RPGRIP1 SYTL4 CADPS PKN3	3.85e-03	137	87	4	SM00239
Pathway	REACTOME_PI5P_REGULATES_TP53_ACETYLATION	PIP4K2A PIP4K2B TP53	6.68e-06	9	62	3	MM15357
Pathway	REACTOME_PI5P_REGULATES_TP53_ACETYLATION	PIP4K2A PIP4K2B TP53	6.68e-06	9	62	3	M27655
Pubmed	Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.	PIP4K2A PIP4K2B TP53	1.51e-08	3	87	3	24209622
Pubmed	Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells.	PIP4K2A PIP4K2B TP53	1.51e-08	3	87	3	34001596
Pubmed	PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay.	PIP4K2A PIP4K2B TP53	6.04e-08	4	87	3	33984270
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CRNKL1 TBC1D4 VPS33B MICAL2 TLN1 PIP4K2A RECQL4 POLRMT PKP1 AMBRA1 RICTOR TFIP11 DDX60L DDX21 DDX39A BAG6	2.21e-07	1353	87	16	29467282
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	CWC27 KIF16B TFIP11 MAP4K4 NEURL4 BAG6 PKN3 TP53	1.24e-06	313	87	8	38270169
Pubmed	Microglia ablation alleviates myelin-associated catatonic signs in mice.	CADPS AMBRA1 DLG2	1.26e-06	9	87	3	29252214
Pubmed	A Novel Mechanism for NF-κB-activation via IκB-aggregation: Implications for Hepatic Mallory-Denk-Body Induced Inflammation.	TBC1D4 POLRMT SUMO2 TP53	2.26e-06	37	87	4	32912968
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	CRNKL1 OXA1L MAN2A2 MAN2A1 VWA8 TLN1 PIP4K2A KIF16B MIF4GD PKP1 PIP4K2B SLC30A1 ECHDC2 MAP4K4 BAG6	2.93e-06	1451	87	15	30550785
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	OXA1L VWA8 SUN2 TLN1 MINK1 ACBD5 KIF16B POLRMT RICTOR TFIP11 SLC30A1 DDX21 MAP4K4 NEURL4 BAG6	3.95e-06	1487	87	15	33957083
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	GINS3 FBXO5 VWA8 CADPS INTS13 SUN2 FBF1 PIP4K2A POLRMT AMBRA1 PIP4K2B RICTOR TP53	4.05e-06	1116	87	13	31753913
Pubmed	Nitric oxide, a mediator of inflammation, suppresses tumorigenesis.	NOS2 TP53	6.19e-06	2	87	2	15466171
Pubmed	Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme.	MAN2A2 MAN2A1	6.19e-06	2	87	2	8524845
Pubmed	Nitric oxide-dependent activation of p53 suppresses bleomycin-induced apoptosis in the lung.	NOS2 TP53	6.19e-06	2	87	2	10993916
Pubmed	TRIM47 promotes malignant progression of renal cell carcinoma by degrading P53 through ubiquitination.	TRIM47 TP53	6.19e-06	2	87	2	33622324
Pubmed	Exosome-dependent immune surveillance at the metastatic niche requires BAG6 and CBP/p300-dependent acetylation of p53.	BAG6 TP53	6.19e-06	2	87	2	31534536
Pubmed	Nitric oxide is a key component in inflammation-accelerated tumorigenesis.	NOS2 TP53	6.19e-06	2	87	2	18757428
Pubmed	The Expression and Correlation of iNOS and p53 in Oral Squamous Cell Carcinoma.	NOS2 TP53	6.19e-06	2	87	2	26523280
Pubmed	HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase.	DCT TP53	6.19e-06	2	87	2	20520707
Pubmed	Overexpression of inducible nitric oxide synthase and accumulation of 8-OHdG in nasopharyngeal carcinoma.	NOS2 TP53	6.19e-06	2	87	2	18184270
Pubmed	Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases.	NOS2 TP53	6.19e-06	2	87	2	11050162
Pubmed	Soluble guanylyl cyclase α1 and p53 cytoplasmic sequestration and down-regulation in prostate cancer.	GUCY1A1 TP53	6.19e-06	2	87	2	22174378
Pubmed	Inflammation regulates microRNA expression in cooperation with p53 and nitric oxide.	NOS2 TP53	6.19e-06	2	87	2	22042537
Pubmed	Inducible nitric oxide synthase, nitrotyrosine and p53 mutations in the molecular pathogenesis of Barrett's esophagus and esophageal adenocarcinoma.	NOS2 TP53	6.19e-06	2	87	2	17849424
Pubmed	Coupled induction of iNOS and p53 upregulation in renal resident cells may be linked with apoptotic activity in the pathogenesis of progressive IgA nephropathy.	NOS2 TP53	6.19e-06	2	87	2	15284293
Pubmed	Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.	PIP4K2A PIP4K2B	6.19e-06	2	87	2	29727621
Pubmed	Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice.	MAN2A2 MAN2A1	6.19e-06	2	87	2	16754854
Pubmed	Elucidation of the integrin LFA-1-mediated signaling pathway of actin polarization in natural killer cells.	WAS TLN1	6.19e-06	2	87	2	20472831
Pubmed	Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells.	FBXO5 TP53	6.19e-06	2	87	2	16861914
Pubmed	RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress.	RECQL4 TP53	6.19e-06	2	87	2	22357944
Pubmed	N-Glycan structure analysis using lectins and an alpha-mannosidase activity assay.	MAN2A2 MAN2A1	6.19e-06	2	87	2	17113875
Pubmed	Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma.	DUSP26 TP53	6.19e-06	2	87	2	20562916
Pubmed	Germ cell survival through carbohydrate-mediated interaction with Sertoli cells.	MAN2A2 MAN2A1	6.19e-06	2	87	2	11778047
Pubmed	Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase MARCH7.	TRIM47 BAG6 TP53	6.73e-06	15	87	3	29295817
Pubmed	LZTR1 is a regulator of RAS ubiquitination and signaling.	SYTL4 MINK1 RICTOR SLC30A1 MAP4K4	1.74e-05	127	87	5	30442766
Pubmed	HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.	BAG6 TP53	1.85e-05	3	87	2	17403783
Pubmed	Expression of p53, inducible nitric oxide synthase and vascular endothelial growth factor in gastric precancerous and cancerous lesions: correlation with clinical features.	NOS2 TP53	1.85e-05	3	87	2	11978184
Pubmed	Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization.	PIP4K2A PIP4K2B	1.85e-05	3	87	2	23758345
Pubmed	Down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by p53 in squamous cell carcinoma.	NOS2 TP53	1.85e-05	3	87	2	12875991
Pubmed	Cross-species genomics identifies DLG2 as a tumor suppressor in osteosarcoma.	DLG2 TP53	1.85e-05	3	87	2	30093633
Pubmed	RECQL4 and p53 potentiate the activity of polymerase γ and maintain the integrity of the human mitochondrial genome.	RECQL4 TP53	1.85e-05	3	87	2	24067899
Pubmed	Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase.	NOS2 TP53	1.85e-05	3	87	2	17940019
Pubmed	Comparison of the fertility of tumor suppressor gene-deficient C57BL/6 mouse strains reveals stable reproductive aging and novel pleiotropic gene.	RECQL4 TP53	1.85e-05	3	87	2	34117297
Pubmed	Zinc Finger 280B regulates sGCα1 and p53 in prostate cancer cells.	GUCY1A1 TP53	1.85e-05	3	87	2	24236047
Pubmed	Nuclear interaction between ADR-induced p65 and p53 mediates cardiac injury in iNOS (-/-) mice.	NOS2 TP53	1.85e-05	3	87	2	24586632
Pubmed	Functional analysis of the biochemical activity of mammalian phosphatidylinositol 5 phosphate 4-kinase enzymes.	PIP4K2A PIP4K2B	1.85e-05	3	87	2	30718367
Pubmed	The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation.	RECQL4 TP53	1.85e-05	3	87	2	25859855
Pubmed	The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site.	PIP4K2A PIP4K2B	1.85e-05	3	87	2	25495341
Pubmed	NEURL4 regulates the transcriptional activity of tumor suppressor protein p53 by modulating its oligomerization.	NEURL4 TP53	1.85e-05	3	87	2	28977907
Pubmed	The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.	PIP4K2A PIP4K2B	1.85e-05	3	87	2	26774281
Pubmed	Loss of p53 in stromal fibroblasts enhances tumor cell proliferation through nitric-oxide-mediated cyclooxygenase 2 activation.	NOS2 TP53	1.85e-05	3	87	2	25511472
Pubmed	[Abnormal expression of p53, Ki67 and iNOS in human esophageal carcinoma in situ and pre-malignant lesions].	NOS2 TP53	1.85e-05	3	87	2	11783017
Pubmed	NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis.	DUSP26 TP53	1.85e-05	3	87	2	26247726
Pubmed	Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders.	DDX21 TP53	1.85e-05	3	87	2	29364875
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CCDC88C EPPK1 MAN2A2 VWA8 COQ4 TLN1 POLRMT TIGD3 LAMB3 AMBRA1 KIFC2 PKN3	1.97e-05	1105	87	12	35748872
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CRNKL1 MAN2A1 CWC27 SCAF8 INTS13 SUN2 TLN1 MINK1 ACBD5 POLRMT RICTOR GNA11 TFIP11 DENND2D	2.01e-05	1497	87	14	31527615
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	VWA8 CADPS MINK1 ACBD5 PKP1 DLG2 PIP4K2B RICTOR NBEA SMPD2 SLC30A1 MAP4K4	2.65e-05	1139	87	12	36417873
Pubmed	A protein interaction landscape of breast cancer.	EPPK1 VWA8 MICAL2 TLN1 POLRMT PKP1 LAMB3 DDX21 TP53	3.04e-05	634	87	9	34591612
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	CRNKL1 FBXO24 CWC27 FBF1 PIP4K2B DDX21 CCDC88B	3.51e-05	361	87	7	26167880
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SCAF8 MINK1 RECQL4 POLRMT LAMB3 AMBRA1 RICTOR TFIP11 MAP4K4	3.69e-05	650	87	9	38777146
Pubmed	Molecular interactions of N-RAP, a nebulin-related protein of striated muscle myotendon junctions and intercalated disks.	NRAP TLN1	3.70e-05	4	87	2	10320340
Pubmed	Modification of DBC1 by SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage.	SUMO2 TP53	3.70e-05	4	87	2	25406032
Pubmed	A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.	PIP4K2A PIP4K2B	3.70e-05	4	87	2	9367159
Pubmed	Mapping of the gene for inducible nitric oxide (NO) synthase of mouse macrophages to chromosome 11, close to Evi-2, nu, and Idd-4.	NOS2 TP53	3.70e-05	4	87	2	7514570
Pubmed	PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.	PIP4K2A PIP4K2B	3.70e-05	4	87	2	31091439
Pubmed	STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathway regulation.	TFIP11 TP53	3.70e-05	4	87	2	26460617
Pubmed	Increased oxidative stress with gene alteration in urinary bladder urothelium after the Chernobyl accident.	NOS2 TP53	3.70e-05	4	87	2	10842192
Pubmed	MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity.	SUMO2 TP53	3.70e-05	4	87	2	21900752
Pubmed	Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities.	RICTOR TP53	3.70e-05	4	87	2	19619545
Pubmed	Anaphylactic shock depends on PI3K and eNOS-derived NO.	GUCY1A1 NOS2	3.70e-05	4	87	2	16886062
Pubmed	Regulation of the MDM2-p53 pathway by the ubiquitin ligase HERC2.	NEURL4 TP53	3.70e-05	4	87	2	31665549
Pubmed	Site-specific inhibition of the small ubiquitin-like modifier (SUMO)-conjugating enzyme Ubc9 selectively impairs SUMO chain formation.	SUMO2 TP53	3.70e-05	4	87	2	28784659
Pubmed	Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma.	RICTOR TP53	3.70e-05	4	87	2	29996106
Pubmed	Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression.	RICTOR TP53	3.70e-05	4	87	2	22958933
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	VWA8 SYTL4 SUN2 PKP1 AMBRA1 SUMO2 DDX39A MAP4K4 NEURL4 BAG6 TP53	4.20e-05	1005	87	11	19615732
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	SYTL4 MINK1 DLG2 PARD3B RICTOR SLC30A1 MAP4K4	4.62e-05	377	87	7	38117590
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	CRNKL1 EPPK1 OXA1L TBC1D4 VWA8 SCAF8 TLN1 PKP1 TFIP11 TRIM47 SLC30A1 DDX21 BAG6	4.92e-05	1415	87	13	28515276
Pubmed	Tumor suppressor p53 represses transcription of RECQ4 helicase.	RECQL4 TP53	6.16e-05	5	87	2	15674334
Pubmed	β-Arrestin-1 protects against endoplasmic reticulum stress/p53-upregulated modulator of apoptosis-mediated apoptosis via repressing p-p65/inducible nitric oxide synthase in portal hypertensive gastropathy.	NOS2 TP53	6.16e-05	5	87	2	26119788
Pubmed	Expression of SUMO-2/3 induced senescence through p53- and pRB-mediated pathways.	SUMO2 TP53	6.16e-05	5	87	2	17012228
Pubmed	The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.	NOS2 TP53	6.16e-05	5	87	2	7507509
Pubmed	Precise coordination of cell-ECM adhesion is essential for efficient melanoblast migration during development.	TLN1 DCT	6.16e-05	5	87	2	32580934
Pubmed	Haematopoietic stem cells require a highly regulated protein synthesis rate.	RICTOR TP53	6.16e-05	5	87	2	24670665
Pubmed	COP9 subunits 4 and 5 target soluble guanylyl cyclase α1 and p53 in prostate cancer cells.	GUCY1A1 TP53	6.16e-05	5	87	2	24725084
Pubmed	HLA-B-associated transcript 3 (Bat3) stabilizes and activates p53 in a HAUSP-dependent manner.	BAG6 TP53	6.16e-05	5	87	2	31647545
Pubmed	Analysis of genetic polymorphisms associated with leukoaraiosis in the southern Chinese population: A case-control study.	FBF1 TRIM47	6.16e-05	5	87	2	27583843
Pubmed	Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain.	PIP4K2A PIP4K2B	6.16e-05	5	87	2	32449185
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	CRNKL1 OXA1L TBC1D4 MICAL2 SUN2 TLN1 UBAC2 GNA11 TFIP11 SUMO2 DDX21 DDX39A	6.36e-05	1247	87	12	27684187
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	DUSP26 GINS3 EPPK1 OXA1L SYTL4 COQ4 ACBD5 MIF4GD LAMB3 RICTOR DENND2D DCT	8.97e-05	1293	87	12	15342556
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	VPS33B SYTL4 MINK1 PARD3B RICTOR SLC30A1 MAP4K4	9.21e-05	421	87	7	36976175
Pubmed	Identification of tuftelin- and amelogenin-interacting proteins using the yeast two-hybrid system.	TFIP11 BAG6	9.22e-05	6	87	2	11063033
Pubmed	Long non-coding RNA Lnc-Tim3 exacerbates CD8 T cell exhaustion via binding to Tim-3 and inducing nuclear translocation of Bat3 in HCC.	BAG6 TP53	9.22e-05	6	87	2	29706626
Pubmed	Repression of SOX6 transcriptional activity by SUMO modification.	SUMO2 TP53	9.22e-05	6	87	2	16442531
Pubmed	Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1.	PIP4K2A PIP4K2B	9.22e-05	6	87	2	14614850
Pubmed	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	RPGRIP1 GINS3 VPS33B CADPS MIF4GD LAMB3 TFIP11 DDX39A TP53	1.02e-04	742	87	9	26871637
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	CCDC88C EPPK1 INTS13 SUN2 SUMO2 DDX21 DDX39A TP53	1.09e-04	583	87	8	29844126
Pubmed	RINT1 Loss Impairs Retinogenesis Through TRP53-Mediated Apoptosis.	ATOH7 TP53	1.29e-04	7	87	2	32850831
Pubmed	Localization of mRNAs for phosphatidylinositol phosphate kinases in the mouse brain during development.	PIP4K2A PIP4K2B	1.29e-04	7	87	2	15018809
Pubmed	Genetic mapping of the beta-arrestin 1 and 2 genes on mouse chromosomes 7 and 11 respectively.	NOS2 TP53	1.29e-04	7	87	2	7613043
Pubmed	Mad1 destabilizes p53 by preventing PML from sequestering MDM2.	SUMO2 TP53	1.29e-04	7	87	2	30948704
Pubmed	Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss.	RICTOR TP53	1.29e-04	7	87	2	35238644
Interaction	ZCCHC10 interactions	CRNKL1 MINK1 PIP4K2A PIP4K2B TFIP11 DDX60L MAP4K4 NEURL4 TP53	7.47e-07	236	86	9	int:ZCCHC10
Interaction	PRPF8 interactions	DUSP26 CRNKL1 EPPK1 VWA8 CWC27 PIP4K2A RECQL4 PKP1 PIP4K2B UBAC2 TFIP11 SUMO2 DDX21 TP53	4.85e-06	776	86	14	int:PRPF8
Interaction	RPL13AP3 interactions	MINK1 RECQL4 MAP4K4 TP53	1.15e-05	33	86	4	int:RPL13AP3
Interaction	WDR83 interactions	RPGRIP1 CRNKL1 EPPK1 FBF1 DDX39A BAG6 TP53	2.08e-05	196	86	7	int:WDR83
Interaction	EAF2 interactions	PIP4K2A TFIP11 DDX39A TP53	2.27e-05	39	86	4	int:EAF2
GeneFamily	Mannosidases alpha class 2	MAN2A2 MAN2A1	8.71e-05	5	54	2	1194
Disease	retinitis pigmentosa (implicated_via_orthology)	RPGRIP1 CWC27 USH2A	5.77e-05	27	82	3	DOID:10584 (implicated_via_orthology)
Disease	platelet component distribution width	DENND2A WAS SYTL4 TNN TLN1 ANKDD1A RMI2 KIF16B SLC30A1	2.48e-04	755	82	9	EFO_0007984
Disease	systolic blood pressure, self reported educational attainment	CADPS CDON	3.38e-04	10	82	2	EFO_0004784, EFO_0006335
Disease	guanosine diphosphate measurement	TBC1D4 NBEA	4.13e-04	11	82	2	EFO_0010494
Disease	Pathological accumulation of air in tissues	NOS2 TP53	4.94e-04	12	82	2	C0013990
Disease	basal cell carcinoma (is_implicated_in)	CRNKL1 TP53	4.94e-04	12	82	2	DOID:2513 (is_implicated_in)
Disease	psoriasis vulgaris	RMI2 CCDC88B NOS2	6.63e-04	61	82	3	EFO_1001494
Disease	Leber hereditary optic neuropathy (is_implicated_in)	RPGRIP1 TP53	6.79e-04	14	82	2	DOID:705 (is_implicated_in)
Disease	cancer (implicated_via_orthology)	PIP4K2A DLG2 PIP4K2B SUMO2 TP53	9.19e-04	268	82	5	DOID:162 (implicated_via_orthology)
Disease	psoriasis	GUCY1A1 RMI2 SPATA31C2 UBAC2 NOS2	9.98e-04	273	82	5	EFO_0000676
Disease	epilepsy (implicated_via_orthology)	SLC12A3 MINK1 MAP4K4 NOS2	1.12e-03	163	82	4	DOID:1826 (implicated_via_orthology)
Disease	psoriasis, type 2 diabetes mellitus	RMI2 CCDC88B NOS2	1.21e-03	75	82	3	EFO_0000676, MONDO_0005148
Disease	Precursor B-cell lymphoblastic leukemia	PIP4K2A TP53	1.55e-03	21	82	2	C1292769
Disease	white matter hyperintensity measurement	CCDC88C FBF1 SUMO2 TRIM47 SLC30A1	1.56e-03	302	82	5	EFO_0005665
Disease	Carcinoma of lung	RICTOR TP53	1.86e-03	23	82	2	C0684249
Disease	Hypertensive disease	SLC12A3 GUCY1A1 NOS2 TP53	1.97e-03	190	82	4	C0020538
Disease	Intrahepatic Cholangiocarcinoma	NOS2 TP53	2.02e-03	24	82	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	NOS2 TP53	2.02e-03	24	82	2	C3805278
Disease	atopic asthma	RMI2 UBAC2 MAP4K4 PKN3	2.33e-03	199	82	4	EFO_0010638
Disease	Cholangiocarcinoma	NOS2 TP53	2.37e-03	26	82	2	C0206698
Disease	colorectal adenocarcinoma (is_marker_for)	RICTOR TP53	2.56e-03	27	82	2	DOID:0050861 (is_marker_for)
Disease	lung small cell carcinoma (is_implicated_in)	LAMB3 RICTOR	2.75e-03	28	82	2	DOID:5409 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RERLMQDGHRQRGLE	CCDC88B	1141	A6NC98
LRFNRRGLVAMANAG	CWC27	91	Q6UX04
GQQMELAAVINGRIR	BAG6	886	P46379
FGRGMDIERVNIVFN	DDX39A	346	O00148
DEFSNVRRGRGHRMQ	ACBD5	401	Q5T8D3
MRRLVAFLNQGQGLA	BHLHE23	161	Q8NDY6
RMRGGRQAALREVEQ	CCDC96	346	Q2M329
RERGARAMGAQRLLQ	AMBRA1	16	Q9C0C7
EGQRQREKMLSRFGR	CER1	71	O95813
NQGAVILLGRTNMFR	KIF16B	536	Q96L93
LLMENAERVGNRGRI	INTS13	146	Q9NVM9
DQDNARVGDRFMRLI	ACP7	176	Q6ZNF0
VQRYNILEEVGRRMG	NOS2	386	P35228
QIRRELDGRLQMADQ	CADPS	306	Q9ULU8
DGRLRMNDQLIAVNG	PARD3B	541	Q8TEW8
LINRRRFQQMDVLEG	MAP4K4	961	O95819
LRMLQREGCFRSQGA	M1AP	96	Q8TC57
RRLMQDDNRGLEQGI	MAN2A1	956	Q16706
RMGQLQSELQYRRGA	NRAP	1336	Q86VF7
QEDRGRRMTQGLGER	GPR179	1176	Q6PRD1
EVGVFVQRLRGLMND	ECHDC2	106	Q86YB7
LNYRQMSGRAGRRGQ	DDX60L	1301	Q5H9U9
LAMGENQRLRGELDR	CCDC88C	1246	Q9P219
QIRGRERFEMFRELN	TP53	331	P04637
REQRMRNQLELAARG	OXA1L	381	Q15070
AVGNDGLQERDRMVR	RICTOR	171	Q6R327
RADRMRRLGDFLNQE	SMPD2	26	O60906
EMLGNVAGARQVFER	CRNKL1	321	Q9BZJ0
RALQERLGQQQRDME	FBF1	781	Q8TES7
ETQMFRGFIQERELR	DENND2A	951	Q9ULE3
RGNFRLQNIIGRKMG	FBXO5	226	Q9UKT4
LENIIFRMVDVGGQR	GNA11	196	P29992
AEFSRGQEGMINLRI	CDON	1206	Q4KMG0
NARERRRMQGLNTAF	ATOH7	46	Q8N100
RDQMRRDPEGAQILQ	COQ4	86	Q9Y3A0
LVDEFGRIFMQGNNR	FBXO24	371	O75426
DRRLMQDDNRGLGQG	MAN2A2	961	P49641
TRMEELRHQARQQGA	LAMB3	1041	Q13751
DGRLQVGDRLLMVNN	DLG2	236	Q15700
QFERMRNGIDILVGT	DDX21	301	Q9NR30
REMNGNRLGRDRIQN	SCAF8	1171	Q9UPN6
FRRQDAQRGMRVAQV	POLRMT	966	O00411
RALQSLFREMGAGRQ	KIFC2	506	Q96AC6
RDGQLQRMNYGRNLE	NEURL4	1016	Q96JN8
QRMNYGRNLERLGVG	NEURL4	1021	Q96JN8
MEGQVVGRVFRLFQR	DENND2D	1	Q9H6A0
MVFRNLRERFGIDDQ	PIP4K2A	96	P48426
VDGQTGENDMNKRRR	MICAL2	666	O94851
NGQRMDELFVLIRDG	MIF4GD	166	A9UHW6
MEAGGERFLRQRQVL	PCDHB3	1	Q9Y5E6
RRGQDFLRASQMNLG	PKN3	436	Q6P5Z2
VYGLIGRRRFQQMDV	MINK1	1051	Q8N4C8
GRRRFQQMDVLEGLN	MINK1	1056	Q8N4C8
ELQGVLRQQGFDRNM	PKP1	716	Q13835
RFGRNTFLGEAEIQM	SYTL4	451	Q96C24
RISRLGQRMSGFQIN	SYPL1	11	Q16563
NGLEQFVGRMQDFRL	USH2A	261	O75445
RRGVDRQVAEGMFER	NUGGC	691	Q68CJ6
MLGRSQGDLRRQEEQ	TRIM47	296	Q96LD4
QGRVVMADRGEARLR	RMI2	61	Q96E14
QQGRRRFLFDMLNGQ	RPGRIP1	1186	Q96KN7
DVFQQMRELGLARRV	TDRD6	186	O60522
RQLEQHMGQRGRIQE	SPATA31C2	451	B4DYI2
ARLDEMERGLFQTGQ	GINS3	166	Q9BRX5
RERRRVQRAFMQGQL	RECQL4	751	O94761
LGLMERDQDRGQQLQ	SCRN2	366	Q96FV2
DIFRNDGSIMLQGVR	JAML	211	Q86YT9
QQDRDLRVDLGFRGM	NBEA	1296	Q8NFP9
MVFRNLRERFGIDDQ	PIP4K2B	101	P78356
RDATMEVQRGQFQGR	EPPK1	2641	P58107
RDATMEVQRGQFQGR	EPPK1	3706	P58107
LQLDARNRGERRMGA	SLC25A36	146	Q96CQ1
MTQQLRGDGLGFRNR	HRC	26	P23327
LGDQDMANNRRELRR	DUSP26	71	Q9BV47
NNVGRMQELIGRRVN	ANKDD1A	26	Q495B1
DRDMGQQGRQVALLL	TIGD3	251	Q6B0B8
FRTVQGEDRNTMFRG	nan	46	Q6ZQY7
GRVGLLQREEMQAQL	SUN2	471	Q9UH99
EMQLGREDQRFALQG	TNN	1016	Q9UQP3
QQQRLREAAEGLRMA	TLN1	886	Q9Y490
DQGGLEAVRQEMRRQ	WAS	296	P42768
RGLQRGVERRVAEAM	SMTNL2	36	Q2TAL5
QGLSMRQIRFRFDGQ	SUMO2	51	P61956
IRVFVGGQINRMDQE	SLC12A3	861	P55017
GTYEGLLRRNQMGRN	DCT	301	P40126
LENIFSRGANRMRGR	TBC1D4	571	O60343
ARIGMGATLDIQRQQ	UBAC2	231	Q8NBM4
EEDRAGQLNMRGVFL	SLC30A1	236	Q9Y6M5
NGEMILADGRRIVAN	VWA8	866	A3KMH1
RREAENMAQRGIGVA	TFIP11	751	Q9UBB9
RNLQAQYDRRRGMDI	VPS33B	306	Q9H267
FGNGIRRLMNRRDFQ	GUCY1A1	301	Q02108