Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium ion binding

NOTCH2NLA DLL1 CD248 NOTCH2NLC CRB2 CRB1

2.62e-04749256GO:0005509
GeneOntologyMolecularFunctionNotch binding

NOTCH2NLA DLL1

5.18e-0427252GO:0005112
GeneOntologyBiologicalProcessregulation of embryonic development

LAMA5 DLL1 CRB2 LAMA1

6.88e-0699264GO:0045995
GeneOntologyBiologicalProcesspositive regulation of Notch signaling pathway

NOTCH2NLA DLL1 NOTCH2NLC

3.99e-0553263GO:0045747
GeneOntologyBiologicalProcessestablishment or maintenance of epithelial cell apical/basal polarity

CRB2 CRB1 LAMA1

5.24e-0558263GO:0045197
GeneOntologyBiologicalProcessestablishment or maintenance of bipolar cell polarity

CRB2 CRB1 LAMA1

6.72e-0563263GO:0061245
GeneOntologyBiologicalProcessestablishment or maintenance of apical/basal cell polarity

CRB2 CRB1 LAMA1

6.72e-0563263GO:0035088
GeneOntologyBiologicalProcessheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

TENM1 CRB2 CRB1

6.72e-0563263GO:0007157
GeneOntologyBiologicalProcessretina development in camera-type eye

DLL1 CRB2 CRB1 LAMA1

1.33e-04211264GO:0060041
GeneOntologyBiologicalProcessretina morphogenesis in camera-type eye

DLL1 CRB2 CRB1

1.94e-0490263GO:0060042
GeneOntologyBiologicalProcessestablishment or maintenance of cell polarity

FSCN3 CRB2 CRB1 LAMA1

2.84e-04257264GO:0007163
GeneOntologyBiologicalProcessodontogenesis of dentin-containing tooth

RSPO2 LAMA5 DLL1

3.24e-04107263GO:0042475
GeneOntologyBiologicalProcessregulation of Notch signaling pathway

NOTCH2NLA DLL1 NOTCH2NLC

3.90e-04114263GO:0008593
GeneOntologyBiologicalProcesssegmentation

LAMA5 DLL1 CRB2

4.87e-04123263GO:0035282
GeneOntologyBiologicalProcessbranching involved in salivary gland morphogenesis

LAMA5 LAMA1

5.66e-0428262GO:0060445
GeneOntologyBiologicalProcessodontogenesis

RSPO2 LAMA5 DLL1

8.84e-04151263GO:0042476
GeneOntologyBiologicalProcesssalivary gland morphogenesis

LAMA5 LAMA1

1.04e-0338262GO:0007435
GeneOntologyBiologicalProcessepithelial tube branching involved in lung morphogenesis

RSPO2 LAMA1

1.22e-0341262GO:0060441
GeneOntologyBiologicalProcesscamera-type eye morphogenesis

DLL1 CRB2 CRB1

1.27e-03171263GO:0048593
GeneOntologyBiologicalProcesssalivary gland development

LAMA5 LAMA1

1.34e-0343262GO:0007431
GeneOntologyBiologicalProcessestablishment of cell polarity

CRB2 CRB1 LAMA1

1.40e-03177263GO:0030010
GeneOntologyBiologicalProcessphotoreceptor cell maintenance

CRB2 CRB1

1.60e-0347262GO:0045494
GeneOntologyCellularComponentsubapical complex

CRB2 CRB1

1.26e-055242GO:0035003
GeneOntologyCellularComponentlaminin complex

LAMA5 LAMA1

5.65e-0510242GO:0043256
GeneOntologyCellularComponentapical plasma membrane

SLC12A1 DLL1 CRB2 CRB1

2.14e-03487244GO:0016324
GeneOntologyCellularComponentcell-cell junction

DLL1 CRB2 CRB1 LAMA1

4.28e-03591244GO:0005911
GeneOntologyCellularComponentapical part of cell

SLC12A1 DLL1 CRB2 CRB1

4.31e-03592244GO:0045177
DomainEGF

NOTCH2NLA TENM1 LAMA5 DLL1 CD248 NOTCH2NLC CRB2 CRB1 LAMA1

1.16e-11235259SM00181
DomainEGF-like_dom

NOTCH2NLA TENM1 LAMA5 DLL1 CD248 NOTCH2NLC CRB2 CRB1 LAMA1

1.95e-11249259IPR000742
DomainEGF_1

NOTCH2NLA TENM1 LAMA5 DLL1 CD248 NOTCH2NLC CRB2 CRB1 LAMA1

2.42e-11255259PS00022
DomainEGF-like_CS

NOTCH2NLA TENM1 LAMA5 DLL1 CD248 NOTCH2NLC CRB2 CRB1 LAMA1

2.98e-11261259IPR013032
DomainEGF_2

NOTCH2NLA TENM1 LAMA5 DLL1 CD248 NOTCH2NLC CRB2 CRB1 LAMA1

3.41e-11265259PS01186
DomainEGF_Ca-bd_CS

NOTCH2NLA DLL1 CD248 NOTCH2NLC CRB2 CRB1

2.74e-0997256IPR018097
DomainEGF_CA

NOTCH2NLA DLL1 CD248 NOTCH2NLC CRB2 CRB1

3.11e-0999256PS01187
DomainEGF-type_Asp/Asn_hydroxyl_site

NOTCH2NLA DLL1 CD248 NOTCH2NLC CRB2 CRB1

4.70e-09106256IPR000152
DomainEGF_CA

NOTCH2NLA DLL1 CD248 NOTCH2NLC CRB2 CRB1

1.10e-08122256SM00179
DomainEGF-like_Ca-bd_dom

NOTCH2NLA DLL1 CD248 NOTCH2NLC CRB2 CRB1

1.21e-08124256IPR001881
DomainEGF

NOTCH2NLA DLL1 CD248 NOTCH2NLC CRB2 CRB1

1.33e-08126256PF00008
DomainEGF_3

NOTCH2NLA TENM1 DLL1 CD248 NOTCH2NLC CRB2 CRB1

1.81e-08235257PS50026
DomainGrowth_fac_rcpt_

RSPO2 LAMA5 DLL1 CD248 CRB1 LAMA1

4.79e-08156256IPR009030
Domain-

LAMA5 PAPPA CRB2 CRB1 LAMA1

1.50e-07952552.60.120.200
DomainLAM_G_DOMAIN

LAMA5 CRB2 CRB1 LAMA1

1.79e-0738254PS50025
DomainASX_HYDROXYL

NOTCH2NLA DLL1 NOTCH2NLC CRB2 CRB1

1.94e-07100255PS00010
DomainLaminin_G_2

LAMA5 CRB2 CRB1 LAMA1

2.21e-0740254PF02210
DomainLamG

LAMA5 CRB2 CRB1 LAMA1

3.27e-0744254SM00282
DomainConA-like_dom

LAMA5 PAPPA BTNL9 CRB2 CRB1 LAMA1

3.57e-07219256IPR013320
DomainLaminin_G

LAMA5 CRB2 CRB1 LAMA1

1.01e-0658254IPR001791
DomainhEGF

DLL1 CRB2 CRB1

6.79e-0628253PF12661
DomainLaminin_aI

LAMA5 LAMA1

1.72e-055252IPR009254
DomainLaminin_I

LAMA5 LAMA1

1.72e-055252PF06008
DomainLaminin_II

LAMA5 LAMA1

1.72e-055252PF06009
DomainLaminin_domII

LAMA5 LAMA1

1.72e-055252IPR010307
DomainLAMININ_IVA

LAMA5 LAMA1

4.79e-058252PS51115
DomainLaminin_B

LAMA5 LAMA1

4.79e-058252PF00052
DomainLamB

LAMA5 LAMA1

4.79e-058252SM00281
DomainLaminin_IV

LAMA5 LAMA1

4.79e-058252IPR000034
DomainEGF_CA

NOTCH2NLA CD248 NOTCH2NLC

2.01e-0486253PF07645
DomainLAMININ_NTER

LAMA5 LAMA1

2.04e-0416252PS51117
DomainLaminin_N

LAMA5 LAMA1

2.04e-0416252PF00055
DomainLaminin_N

LAMA5 LAMA1

2.04e-0416252IPR008211
DomainLamNT

LAMA5 LAMA1

2.04e-0416252SM00136
DomainEGF_LAM_2

LAMA5 LAMA1

7.31e-0430252PS50027
DomainEGF_LAM_1

LAMA5 LAMA1

7.31e-0430252PS01248
DomainLaminin_EGF

LAMA5 LAMA1

9.96e-0435252PF00053
DomainEGF_Lam

LAMA5 LAMA1

9.96e-0435252SM00180
DomainLaminin_EGF

LAMA5 LAMA1

1.17e-0338252IPR002049
DomainSUSHI

PAPPA CD248

2.53e-0356252PS50923
DomainSushi_SCR_CCP_dom

PAPPA CD248

2.62e-0357252IPR000436
DomainGalactose-bd-like

LAMA5 LAMA1

6.97e-0394252IPR008979
PathwayPID_INTEGRIN4_PATHWAY

LAMA5 LAMA1

5.78e-0511152M158
PathwayREACTOME_LAMININ_INTERACTIONS

LAMA5 LAMA1

4.52e-0430152M27216
PathwayREACTOME_MET_ACTIVATES_PTK2_SIGNALING

LAMA5 LAMA1

4.52e-0430152M27772
PathwayWP_ALPHA_6_BETA_4_SIGNALING

LAMA5 LAMA1

5.47e-0433152M39503
PathwayREACTOME_MET_PROMOTES_CELL_MOTILITY

LAMA5 LAMA1

8.46e-0441152M27778
PathwayPID_A6B1_A6B4_INTEGRIN_PATHWAY

LAMA5 LAMA1

1.06e-0346152M239
PathwayREACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS

LAMA5 LAMA1

1.75e-0359152M27218
PathwayWP_ALPHA_6_BETA_4_INTEGRIN_SIGNALING_PATHWAY

LAMA5 LAMA1

2.18e-0366152MM15925
PathwayPID_INTEGRIN1_PATHWAY

LAMA5 LAMA1

2.18e-0366152M18
PathwayREACTOME_ECM_PROTEOGLYCANS

LAMA5 LAMA1

2.88e-0376152M27219
PathwayREACTOME_SIGNALING_BY_MET

LAMA5 LAMA1

3.11e-0379152M27643
PathwayKEGG_ECM_RECEPTOR_INTERACTION

LAMA5 LAMA1

3.50e-0384152M7098
PathwayKEGG_SMALL_CELL_LUNG_CANCER

LAMA5 LAMA1

3.50e-0384152M3228
Pubmed

Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation.

NOTCH2NLA DLL1 NOTCH2NLC

3.70e-09526329856955
Pubmed

Crumbs proteins regulate layered retinal vascular development required for vision.

CRB2 CRB1

5.37e-07226231718797
Pubmed

Expression and localization of the polarity protein CRB2 in adult mouse brain: a comparison with the CRB1rd8 mutant mouse model.

CRB2 CRB1

5.37e-07226230076417
Pubmed

Human iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Müller Glia Are Targets of AAV5.

CRB2 CRB1

5.37e-07226230956116
Pubmed

Human CRB1 and CRB2 form homo- and heteromeric protein complexes in the retina.

CRB2 CRB1

5.37e-07226238570189
Pubmed

CRB2 acts as a modifying factor of CRB1-related retinal dystrophies in mice.

CRB2 CRB1

5.37e-07226224565864
Pubmed

CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function.

CRB2 CRB1

5.37e-07226229893966
Pubmed

Presynaptic congenital myasthenic syndrome with a homozygous sequence variant in LAMA5 combines myopia, facial tics, and failure of neuromuscular transmission.

LAMA5 LAMA1

5.37e-07226228544784
Pubmed

Perturbed cell cycle phase-dependent positioning and nuclear migration of retinal progenitors along the apico-basal axis underlie global retinal disorganization in the LCA8-like mouse model.

CRB2 CRB1

5.37e-07226239284539
Pubmed

The laminin response in inflammatory bowel disease: protection or malignancy?

LAMA5 LAMA1

5.37e-07226225347196
Pubmed

[Correlation between ultrastructural changes of glomerular basement membrane and abnormal distribution of laminins in patients with Alport's syndrome].

LAMA5 LAMA1

5.37e-07226220019771
Pubmed

Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis.

CRB2 CRB1

5.37e-07226224339791
Pubmed

Impaired fetal muscle development and JAK-STAT activation mark disease onset and progression in a mouse model for merosin-deficient congenital muscular dystrophy.

LAMA5 DLL1 LAMA1

5.66e-072226328334989
Pubmed

Targeted deletion of Crb1/Crb2 in the optic vesicle models key features of leber congenital amaurosis 8.

CRB2 CRB1

1.61e-06326231145883
Pubmed

α1- and α5-containing laminins regulate the development of bile ducts via β1 integrin signals.

LAMA5 LAMA1

1.61e-06326222761447
Pubmed

CRB2 Loss in Rod Photoreceptors Is Associated with Progressive Loss of Retinal Contrast Sensitivity.

CRB2 CRB1

1.61e-06326231438467
Pubmed

Expression of laminin alpha 1, alpha 5 and beta 2 chains during embryogenesis of the kidney and vasculature.

LAMA5 LAMA1

1.61e-0632629049978
Pubmed

Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences.

LAMA5 LAMA1

1.61e-0632629006922
Pubmed

Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background.

CRB2 CRB1

1.61e-06326224324803
Pubmed

Heterologously overexpressed, affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro.

LAMA5 LAMA1

1.61e-06326210620696
Pubmed

Overexpression of human CRB1 or related isoforms, CRB2 and CRB3, does not regulate the human presenilin complex in culture cells.

CRB2 CRB1

1.61e-06326217988153
Pubmed

Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells.

LAMA5 LAMA1

1.61e-06326212393739
Pubmed

Laminin compensation in collagen alpha3(IV) knockout (Alport) glomeruli contributes to permeability defects.

LAMA5 LAMA1

3.22e-06426217699809
Pubmed

Laminin-1 reexpression in Alport mouse glomerular basement membranes.

LAMA5 LAMA1

3.22e-06426212631063
Pubmed

Developmental regulation of the laminin alpha5 chain suggests a role in epithelial and endothelial cell maturation.

LAMA5 LAMA1

3.22e-0642629299121
Pubmed

Evolution of Human Brain Size-Associated NOTCH2NL Genes Proceeds toward Reduced Protein Levels.

NOTCH2NLA NOTCH2NLC

3.22e-06426232330268
Pubmed

Expression of laminin chains by central neurons: analysis with gene and protein trapping techniques.

LAMA5 LAMA1

3.22e-06426212820173
Pubmed

Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex.

NOTCH2NLA NOTCH2NLC

3.22e-06426229561261
Pubmed

Expression and distribution of laminin alpha1 and alpha2 chains in embryonic and adult mouse tissues: an immunochemical approach.

LAMA5 LAMA1

5.37e-06526211969289
Pubmed

Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis.

NOTCH2NLA NOTCH2NLC

5.37e-06526229856954
Pubmed

Laminin gamma2 expression is developmentally regulated during murine tooth morphogenesis and is intense in ameloblasts.

LAMA5 LAMA1

5.37e-0652629719032
Pubmed

Laminin-10 is crucial for hair morphogenesis.

LAMA5 LAMA1

5.37e-06526212743034
Pubmed

Complete sequence, recombinant analysis and binding to laminins and sulphated ligands of the N-terminal domains of laminin alpha3B and alpha5 chains.

LAMA5 LAMA1

5.37e-06526211829758
Pubmed

Posttranslational modifications and beta/gamma chain associations of human laminin alpha1 and laminin alpha5 chains: purification of laminin-3 from placenta.

LAMA5 LAMA1

5.37e-06526210964500
Pubmed

Differential expression of five laminin alpha (1-5) chains in developing and adult mouse kidney.

LAMA5 LAMA1

5.37e-0652629415429
Pubmed

Differential expression of laminin alpha chains during murine tooth development.

LAMA5 LAMA1

5.37e-0652629389447
Pubmed

Laminin is the ECM niche for trophoblast stem cells.

LAMA5 LAMA1

8.05e-06626231937556
Pubmed

Laminin alpha1 globular domains 4-5 induce fetal development but are not vital for embryonic basement membrane assembly.

LAMA5 LAMA1

8.05e-06626215668394
Pubmed

HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium.

LAMA5 LAMA1

8.05e-0662629597096
Pubmed

Laminin isoforms in fetal and adult human adrenal cortex.

LAMA5 LAMA1

1.13e-05726214557481
Pubmed

Abscence of laminin alpha1 chain in the skeletal muscle of dystrophic dy/dy mice.

LAMA5 LAMA1

1.13e-0572629390664
Pubmed

Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Muller glia cells.

CRB2 CRB1

1.13e-05726216885194
Pubmed

Beta1 integrins are required for the invasion of the caecum and proximal hindgut by enteric neural crest cells.

LAMA5 LAMA1

1.50e-05826219633172
Pubmed

Laminin-1 promotes differentiation of fetal mouse pancreatic beta-cells.

LAMA5 LAMA1

1.50e-05826210102687
Pubmed

Cloning and expression analyses of mouse dystroglycan gene: specific expression in maternal decidua at the peri-implantation stage.

LAMA5 LAMA1

1.50e-0582628872465
Pubmed

Asymmetric distribution of CRUMBS polarity complex proteins from compacted 8-cell to blastocyst stage during mouse preimplantation development.

CRB2 CRB1

1.50e-05826229155075
Pubmed

Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment.

LAMA5 LAMA1

1.50e-05826219651211
Pubmed

FERM protein EPB41L5 is a novel member of the mammalian CRB-MPP5 polarity complex.

CRB2 CRB1

1.50e-05826217920587
Pubmed

Expression and localization of laminin-5 subunits during mouse tooth development.

LAMA5 LAMA1

1.50e-0582629489770
Pubmed

Roles for laminin in embryogenesis: exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha5 chain.

LAMA5 LAMA1

1.50e-0582629852162
Pubmed

A mutation affecting laminin alpha 5 polymerisation gives rise to a syndromic developmental disorder.

LAMA5 LAMA1

1.50e-05826232439764
Pubmed

Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome.

LAMA5 LAMA1

1.93e-05926210880400
Pubmed

Expression of laminin alpha1, alpha2, alpha4, and alpha5 chains, fibronectin, and tenascin-C in skeletal muscle of dystrophic 129ReJ dy/dy mice.

LAMA5 LAMA1

1.93e-0592629882526
Pubmed

Compositional and structural requirements for laminin and basement membranes during mouse embryo implantation and gastrulation.

LAMA5 LAMA1

1.93e-05926215102706
Pubmed

Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality.

LAMA5 LAMA1

1.93e-05926230456378
Pubmed

Integrin alpha6beta1-laminin interactions regulate early myotome formation in the mouse embryo.

LAMA5 LAMA1

2.41e-051026216554364
Pubmed

Functional consequences of cell type-restricted expression of laminin α5 in mouse placental labyrinth and kidney glomerular capillaries.

LAMA5 LAMA1

2.41e-051026222911783
Pubmed

Generation of a conditionally null allele of the laminin alpha1 gene.

LAMA5 LAMA1

2.41e-051026216100707
Pubmed

Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro.

LAMA5 LAMA1

2.41e-051026218590826
Pubmed

Trophoblast-specific expression and function of the integrin alpha 7 subunit in the peri-implantation mouse embryo.

LAMA5 LAMA1

2.41e-051026211784026
Pubmed

Primary cellular meningeal defects cause neocortical dysplasia and dyslamination.

LAMA5 LAMA1

2.41e-051026220976766
Pubmed

Distribution of the ten known laminin chains in the pathways and targets of developing sensory axons.

LAMA5 LAMA1

2.41e-05102629034910
Pubmed

Laminin alpha 5 is required for lobar septation and visceral pleural basement membrane formation in the developing mouse lung.

LAMA5 LAMA1

2.94e-051126212051813
Pubmed

Regional differences in the expression of laminin isoforms during mouse neural tube development.

LAMA5 LAMA1

2.94e-051126221524702
Pubmed

Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities.

LAMA5 LAMA1

2.94e-051126223472759
Pubmed

Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice.

LAMA5 LAMA1

3.53e-05122629396756
Pubmed

Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis.

LAMA5 LAMA1

3.53e-051226211381080
Pubmed

Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse.

LAMA5 LAMA1

3.53e-051226210433923
Pubmed

Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function.

LAMA5 LAMA1

3.53e-051226216750824
Pubmed

The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut.

LAMA5 LAMA1

4.17e-051326236350252
Pubmed

Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane.

LAMA5 LAMA1

4.17e-051326212682087
Pubmed

Fukutin-related protein alters the deposition of laminin in the eye and brain.

LAMA5 LAMA1

4.17e-051326221900571
Pubmed

The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform.

LAMA5 LAMA1

4.86e-05142629151674
Pubmed

Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome.

LAMA5 LAMA1

4.86e-051426219783738
Pubmed

Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane.

LAMA5 LAMA1

5.61e-051526210625553
Pubmed

Laminin alpha5 chain is required for intestinal smooth muscle development.

LAMA5 LAMA1

5.61e-051526212921739
Pubmed

Localization of basement membrane-associated protein isoforms during development of the ocular surface of mouse eye.

LAMA5 LAMA1

5.61e-05152629264260
Pubmed

Basement membrane composition in the early mouse embryo day 7.

LAMA5 LAMA1

5.61e-051526215895400
Pubmed

Efficient and fast targeted production of murine models based on ENU mutagenesis.

DLL1 CRB2

5.61e-051526216075367
Pubmed

ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice.

LAMA5 LAMA1

6.41e-051626230579834
Pubmed

The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation.

LAMA5 LAMA1

6.41e-051626219733164
Pubmed

Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling.

LAMA5 LAMA1

6.41e-051626217601529
Pubmed

Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.

DLL1 LAMA1

6.41e-051626217229764
Pubmed

Beta1-integrins are critical for cerebellar granule cell precursor proliferation.

LAMA5 LAMA1

7.26e-051726215056720
Pubmed

Laminin α1 is essential for mouse cerebellar development.

LAMA5 LAMA1

7.26e-051726221983115
Pubmed

ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.

LAMA5 LAMA1

8.16e-051826239040056
Pubmed

Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53.

LAMA5 LAMA1

8.16e-051826211311202
Pubmed

Notch is required for the formation of all nephron segments and primes nephron progenitors for differentiation.

SLC12A1 LAMA1

8.16e-051826229113990
Pubmed

A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.

LAMA5 LAMA1

8.16e-051826214730302
Pubmed

Transcriptional fates of human-specific segmental duplications in brain.

NOTCH2NLA NOTCH2NLC

9.12e-051926230228200
Pubmed

Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis.

CRB2 CRB1

9.12e-051926222398208
Pubmed

The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo.

CRB2 CRB1

9.12e-051926217507402
Pubmed

Yap/Taz are required for establishing the cerebellar radial glia scaffold and proper foliation.

CRB2 CRB1

9.12e-051926231586559
Pubmed

Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon.

CRB2 CRB1

1.01e-042026226802325
Pubmed

Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: implications for regulation of BMP signalling.

LAMA5 LAMA1

1.01e-042026222911573
Pubmed

Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye.

CRB2 CRB1

1.01e-042026227616714
Pubmed

Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders.

TENM1 LAMA1

1.23e-042226235245678
Pubmed

Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation.

DLL1 LAMA1

1.23e-042226215496443
Pubmed

Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation.

CRB2 CRB1

1.23e-042226227870829
Pubmed

A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.

WDR27 DLL1

1.23e-042226221980299
Cytoband6q27

WDR27 DLL1

4.50e-04552626q27
CytobandEnsembl 112 genes in cytogenetic band chr6q27

WDR27 DLL1

9.48e-0480262chr6q27
CytobandEnsembl 112 genes in cytogenetic band chr9q33

PAPPA CRB2

2.78e-03138262chr9q33
GeneFamilyPDZ domain containing|Crumbs complex

CRB2 CRB1

2.98e-0591721223
GeneFamilyLaminin subunits

LAMA5 LAMA1

5.46e-0512172626
CoexpressionGSE45365_CTRL_VS_MCMV_INFECTION_NK_CELL_UP

ZFYVE19 CD248 BTNL9 LAMA1

3.67e-05200254M10026
CoexpressionAtlasDevelopingKidney_e14.5 whole kidney - wildtype_emap-6674_k-means-cluster#3_top-relative-expression-ranked_200

DLL1 ZCCHC3 LAMA1

6.99e-0632253gudmap_developingKidney_e14.5 whole kidney - wildtype_200_k3
CoexpressionAtlasDevelopingKidney_e14.5 whole kidney - wildtype_emap-6674_top-relative-expression-ranked_200

SLC12A1 DLL1 ZCCHC3 LAMA1

2.77e-05151254gudmap_developingKidney_e14.5 whole kidney - wildtype_emap-6674_200
CoexpressionAtlasDevelopingKidney_e15.5_S-shaped body_emap-27855_top-relative-expression-ranked_200

SLC12A1 DLL1 BTNL9 LAMA1

3.64e-05162254gudmap_developingKidney_e15.5_S-shaped body_200
CoexpressionAtlasAravindRamakr_EmbryoidBody-LF_top-relative-expression-ranked_2500_k-means-cluster#2

RSPO2 PAPPA GRIN2D CD248 CRB2 CRB1 LAMA1

8.36e-05951257Arv_EB-LF_2500_K2
CoexpressionAtlasDevelopingKidney_e15.5_S-shaped body_emap-27855_top-relative-expression-ranked_500

SLC12A1 DLL1 BTNL9 RUNDC1 LAMA1

9.66e-05406255gudmap_developingKidney_e15.5_S-shaped body_500
CoexpressionAtlasDevelopingKidney_e14.5 whole kidney - wildtype_emap-6674_top-relative-expression-ranked_100

SLC12A1 DLL1 LAMA1

1.03e-0478253gudmap_developingKidney_e14.5 whole kidney - wildtype_emap-6674_100
CoexpressionAtlasProgenitor-Cell-Biology-Consortium_EmbryoidBody_from_inducedPluripotentialStemCells_derived from_from_fibroblast_top-relative-expression-ranked_1000

RSPO2 PAPPA GRIN2D DLL1 CRB2 CRB1 LAMA1

1.05e-04986257PCBC_EB_fibroblast_1000
CoexpressionAtlasAravindRamakr_EmbryoidBody-LF_top-relative-expression-ranked_1000_k-means-cluster#4

RSPO2 PAPPA CRB2 CRB1 LAMA1

1.31e-04433255Arv_EB-LF_1000_K4
CoexpressionAtlasDevelopingKidney_e14.5 whole kidney - wildtype_emap-6674_k-means-cluster#5_top-relative-expression-ranked_100

DLL1 LAMA1

2.25e-0419252gudmap_developingKidney_e14.5 whole kidney - wildtype_100_k5
CoexpressionAtlasDevelopingKidney_e14.5 whole kidney - wildtype_emap-6674_k-means-cluster#5_top-relative-expression-ranked_500

DLL1 ZCCHC3 LAMA1

2.50e-04105253gudmap_developingKidney_e14.5 whole kidney - wildtype_500_k5
CoexpressionAtlasDevelopingKidney_e15.5_S-shaped body_emap-27855_top-relative-expression-ranked_1000

LAMA5 SLC12A1 DLL1 BTNL9 RUNDC1 LAMA1

2.89e-04811256gudmap_developingKidney_e15.5_S-shaped body_1000
ToppCelldroplet-Kidney-nan-21m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WDR27 CD248 FSCN3 CRB2

3.69e-06183264f55081068213cc1cdb2acad58ff10f6b48b44c72
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 RSPO2 PAPPA GRIN2D

4.02e-06187264d413fb4b1531b297af5012a392b88128510c2de8
ToppCellwk_08-11-Mesenchymal-Mesothelial-Early_mesothelial|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

LAMA5 PAPPA GASK1A CRB2

4.11e-061882646151051c027c7ff7d5d4bf5f1e11d7fe58eb22ed
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 RSPO2 PAPPA GRIN2D

4.28e-06190264305fbef734c350cfbf786ca7ff6e07093aab56ea
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

LAMA5 PAPPA GASK1A CRB2

4.37e-061912644c4eb61e6179d2f8fc524d2f813db9cba84f67a2
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 RSPO2 PAPPA GRIN2D

4.56e-0619326453bcd50892c379b2a571751f6eb1062436339fe7
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 RSPO2 PAPPA GRIN2D

4.56e-061932645581a5ebcd21a2a8062ccfb917f088ec67a10a9c
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)|Neuronal / cells hierarchy compared to all cells using T-Statistic

TENM1 RSPO2 PAPPA GRIN2D

5.25e-06200264107854f4855fc99c9f7e737eb246f0d868e6c5fd
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC12A1 CRB1 LAMA1

1.08e-04160263c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC12A1 CRB1 LAMA1

1.08e-0416026325c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(RGS5+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMA5 PAPPA CRB2

1.41e-04175263f5451c29c487b998778e50349b3d774d5e20fd28
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PAPPA GRIN2D

1.43e-04176263682a1dfcc507ec540f5fadf08e872533ea9f0291
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RSPO2 ZNF202 CD248

1.46e-0417726330f82b04e48940bfcaf2c22677efe6d57ae3f1a7
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PAPPA GRIN2D

1.48e-041782636ad46b0720298bcb927fd53468bb4ea0c199ad35
ToppCell-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

PAPPA CD248 CRB2

1.56e-04181263ef579e958f334da0f9415aa7e3d5c02c807954a6
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 RSPO2 PAPPA

1.58e-04182263a3c5c0eff527c8d3848acda14af8f9e99c69b0de
ToppCellBasal|World / shred by cell class for mouse tongue

LAMA5 PAPPA DLL1

1.61e-04183263c6729a207526ff4aa48176207b9353176f631fea
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PAPPA GRIN2D

1.61e-04183263121791ef84e7ce377ed6f5b7953af8865e04958e
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAPPA CD248 CRB2

1.61e-04183263ebe369dc80c4fbf8f4dbe947147f8c47507ffb60
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 RSPO2 PAPPA

1.66e-04185263f4ac62009c0ad3346e71b809e17727303c4df153
ToppCell343B-Fibroblasts-Fibroblast-E|343B / Donor, Lineage, Cell class and subclass (all cells)

PAPPA CD248 GASK1A

1.69e-0418626359db239f1864a5d4f1570c93219dbd7ac5b6db35
ToppCell343B-Fibroblasts-Fibroblast-E-|343B / Donor, Lineage, Cell class and subclass (all cells)

PAPPA CD248 GASK1A

1.69e-041862631bac7825c2fe3e6cdff65026b09b9ccaa40fa27f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 RSPO2 GRIN2D

1.69e-041862636379609b7ace80683f5754b16aa77f11b43766ae
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

LAMA5 PAPPA CRB2

1.71e-041872638e8f1f2a78ac5f13a414fd448af7d7ff1ea86f0f
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMA5 PAPPA DLL1

1.74e-04188263997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCellEC-Sinusoidal_ECs|World / Lineage and Cell class

LAMA5 DLL1 BTNL9

1.77e-041892639a0956c8a7069ba3bd0fa56d052d6e514453e578
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PAPPA GRIN2D

1.79e-041902633f22c118d552345f731d4d49f0bcb5765d93de3b
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PAPPA GRIN2D

1.79e-04190263d19bc44310c53726e2f5f6a2bd377bbbf1d1983f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PAPPA GRIN2D

1.79e-04190263e58e4b6fbeb4368f738adac67ec10879c0966f0f
ToppCell15-Trachea-Epithelial-Submucosal_gland_basal|Trachea / Age, Tissue, Lineage and Cell class

PAPPA GASK1A LAMA1

1.82e-04191263409e12d2bb26b6d2ed025304ca6ace07df16638a
ToppCellControl-Stromal_mesenchymal|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RSPO2 PAPPA GASK1A

1.82e-0419126314057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCellEC|World / Lineage and Cell class

LAMA5 DLL1 BTNL9

1.85e-04192263478866dd5b0d6ff3a76d07a17c4b5989dd7a27bb
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PAPPA CRB1

1.88e-04193263d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TENM1 PAPPA GRIN2D

1.88e-041932634979862c0c16e6b4baa4c79894f1d237c861f5a5
ToppCellfacs-MAT-Fat-3m-Endothelial-endothelial_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA5 DLL1 BTNL9

1.88e-04193263e164f6403a8b541ced08a6feec915d2e855036ea
ToppCellfacs-MAT-Fat-3m-Endothelial|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA5 DLL1 BTNL9

1.88e-04193263b32533afeff1905e188becaa09079e9699722e4b
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RSPO2 PAPPA CD248

1.88e-041932635bee7abc550ddaa28cbb3b9ecaf6b924ab175de0
ToppCellfacs-MAT-Fat-3m-Endothelial-nan|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA5 DLL1 BTNL9

1.88e-041932632ff573ba2c74583ed1cb071a3bbc01bb71117e5f
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts-Subpleural_fibroblasts_L.2.1.5.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PAPPA CD248 CRB2

1.94e-041952630866aaf053762d1a021fcbccff058526078a99da
ToppCellwk_08-11-Mesenchymal-Mesothelial|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

PAPPA GASK1A CRB2

1.94e-041952639016a44b521214546a55a822ebdef5b5312206d2
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts-Subpleural_fibroblasts_L.2.1.5.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PAPPA CD248 CRB2

1.97e-0419626346d665de09f8164690b9a3e0acf0b0afa3f81b3d
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TENM1 PAPPA GASK1A

2.00e-0419726344673c38384453207871d3fd8e8ba9093cc06bc5
ToppCelldistal-mesenchymal-Lipofibroblast-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PAPPA CD248 CRB2

2.00e-04197263865010edcd7e3f79f505fcef7b33882095994aa8
ToppCelldistal-mesenchymal-Lipofibroblast|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PAPPA CD248 CRB2

2.00e-04197263ceb83bdef16b58ee16193413bfb006f7715728b2
ToppCellParenchymal-10x3prime_v2-Stromal-Mesofibroblastic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

FSCN3 CRB2 LAMA1

2.03e-041982630cd930e374c2c48d1991b51c025f9801b22ecee7
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NOTCH2NLA RSPO2 LAMA5

2.03e-04198263399760b6b6fef8639ded53b14f251b9fce600e81
ToppCellParenchymal-10x3prime_v2-Stromal-Mesofibroblastic-Mesothelia|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

FSCN3 CRB2 LAMA1

2.03e-04198263e0df6d6ff2a9c41d813f84a2a5ee7cb5f6fc3e30
ToppCelldistal-2-mesenchymal-Adventitial_Fibroblast|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

RSPO2 PAPPA CD248

2.06e-0419926397b475f9110ef7bb29d9cf2109b7e43177830f05
ToppCell368C-Fibroblasts-Fibroblast-D-|368C / Donor, Lineage, Cell class and subclass (all cells)

PAPPA CD248 GASK1A

2.06e-041992635a425e7d11c5911ff5855c27a7f058a7ed7abbb0
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMA5 PAPPA DLL1

2.06e-04199263edba1833ef5c4ca122d7c32f97670314e005f93b
ToppCell368C-Fibroblasts-Fibroblast-D|368C / Donor, Lineage, Cell class and subclass (all cells)

PAPPA CD248 GASK1A

2.06e-0419926366545eb7f65e450b742628fd431956e13330a0d3
ToppCell(5)_Fibroblast-D|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

PAPPA CD248 GASK1A

2.06e-041992633f415620ad8b8d8c6871e1353e13f87b281fcc0e
ToppCell343B-Fibroblasts-Fibroblast-F|343B / Donor, Lineage, Cell class and subclass (all cells)

PAPPA CD248 GASK1A

2.06e-04199263b877c1d24357249781032e99d4237f72789cc9b8
ToppCell343B-Fibroblasts-Fibroblast-F-|343B / Donor, Lineage, Cell class and subclass (all cells)

PAPPA CD248 GASK1A

2.06e-04199263e32fa66f3361474088ba1dd58574822537950d59
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.4.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PAPPA CD248 GASK1A

2.06e-0419926366b4ff23b2e83fb7e6a37fdafdef315cfa33d327
ToppCellNeuronal-Excitatory-eC(RORB)-eC_1-CARM1P1|Neuronal / cells hierarchy compared to all cells using T-Statistic

NOTCH2NLA NOTCH2NLC BTNL9

2.09e-04200263f75d95376a340d467c4392b872b2a2dbdd184556
ToppCellLung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-2,_SCARA5-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PAPPA CD248 GASK1A

2.09e-042002630b2614b8513693dd508c9003699049efd9abac52
ToppCellNeuronal-Excitatory-eC(RORB)-eC_1-CARM1P1--L3-4|Neuronal / cells hierarchy compared to all cells using T-Statistic

NOTCH2NLA NOTCH2NLC BTNL9

2.09e-0420026347791c93d03ee17c1ce17e27f075be4fc6f2590e
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-SULF1--L4-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

TENM1 RSPO2 PAPPA

2.09e-042002634a426ef88376d8bb2b9dc50aa06e7b9fc50ecc9c
ToppCellNeuronal-Excitatory-eC(RORB)-eC_1-CARM1P1-|Neuronal / cells hierarchy compared to all cells using T-Statistic

NOTCH2NLA NOTCH2NLC BTNL9

2.09e-04200263fae26560ba3b0b638b6bcf92f05330824b31d21b
ToppCell390C-Fibroblasts-Fibroblast-H-|390C / Donor, Lineage, Cell class and subclass (all cells)

PAPPA CD248 GASK1A

2.09e-04200263ec7d6a08e34bcad5b3bbff56ebef96ae17e4cefd
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)|Neuronal / cells hierarchy compared to all cells using T-Statistic

TENM1 PAPPA GRIN2D

2.09e-042002631276bfa911fddada4235e12e3081baa53164574b
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Mesothelial-2-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PAPPA CD248 GASK1A

2.09e-04200263d276062545ecc428a28b12a74f06f3c6bbcff4a3
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PAPPA CD248 GASK1A

2.09e-042002630e1f9e1622e5a0fd814a1e100f79cbca2e0dbfbb
ToppCellParenchymal-10x5prime-Stromal-Fibroblastic-Fibro_adventitial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PAPPA CD248 GASK1A

2.09e-042002636b48ddde83bc6c941d557844aa214d4d2c8e736d
ToppCellParenchyma_Control_(B.)-Stromal-TX-Mesothelial-2|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

PAPPA CD248 GASK1A

2.09e-04200263b33901d91b3af5c0cf310eede30ce03af90c9783
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-SULF1|Neuronal / cells hierarchy compared to all cells using T-Statistic

TENM1 RSPO2 PAPPA

2.09e-04200263fbeee1c16ac0a7fe28d90491c8b079f21ce80bdc
ToppCell(5)_Fibroblast-H|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

PAPPA CD248 GASK1A

2.09e-0420026394e77a1082ade6fad93a37168e037af8aefe7ff4
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-SULF1-|Neuronal / cells hierarchy compared to all cells using T-Statistic

TENM1 RSPO2 PAPPA

2.09e-04200263c6eda342ea0cb37d71d89dbb8d11e819e0745172
ToppCell390C-Fibroblasts-Fibroblast-H|390C / Donor, Lineage, Cell class and subclass (all cells)

PAPPA CD248 GASK1A

2.09e-04200263671e731977c58a0c44c36b56422085d93d999aad
ToppCellParenchymal-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PAPPA CD248 GASK1A

2.09e-0420026354806080b5e97859ee6a4a9b4f19e22021c218f5
ToppCellTransplant_Alveoli_and_parenchyma-Mesenchymal-Mesothelium|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

PAPPA CD248 CRB2

2.09e-04200263c082bc21ec7c5323439d108ea8aea510e1113c3f
ToppCellParenchyma_COVID-19-Stromal-TX-Fibroblasts-2,_SCARA5|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

PAPPA CD248 GASK1A

2.09e-04200263c338a08c1605527ab9aaf62ea151a19e8469dc6d
ToppCellBronchus_Control_(B.)-Stromal-TX-Fibroblasts-4|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

PAPPA CD248 GASK1A

2.09e-0420026354b18c92daaa3b3368c0c46134b0c27e10c8dbb0
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Mesothelial-2|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

PAPPA CD248 GASK1A

2.09e-0420026323bc13983f6bdf95e63109b8bc14c4921ca85c3a
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PAPPA CD248 CRB2

2.09e-04200263d64895354218ebd0217011bae0967a6883bbd1cd
ToppCellLung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-2,_SCARA5|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PAPPA CD248 GASK1A

2.09e-042002638d2ceb2080c67b20f452eeca605aa27a58033c04
ToppCellNeuronal-Inhibitory-iB|Neuronal / cells hierarchy compared to all cells using T-Statistic

TENM1 PAPPA GRIN2D

2.09e-0420026345ddc5ef2caa87ada88327b63ba9b150a6bb3aa5
ToppCellParenchymal-10x5prime-Stromal-Fibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PAPPA CD248 GASK1A

2.09e-042002636e3d1ae0ef84d3075afa40129a41169996462672
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6-Excitatory_Neuron.Slc17a7.Bcl6-Tshz2-Syt2_(Layer_5a,_Entorhinal_cortex,_Tshz1+)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

WDR27 BTNL9

4.02e-0451262adc73d6909d75ad432aef884dae540b7e48cecd6
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gata3_(Periacqueductal_gray_(PAG)_(or_adjacent_APTD))--|Thalamus / BrainAtlas - Mouse McCarroll V32

RSPO2 SLC12A1

5.03e-04572629614fe2acc6ee039383504f94bbe6d35aac27f25
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gata3_(Periacqueductal_gray_(PAG)_(or_adjacent_APTD))-|Thalamus / BrainAtlas - Mouse McCarroll V32

RSPO2 SLC12A1

5.03e-04572623c55a5598a7ea789500f2fbd35c79d2b97a3fc7d
ToppCellThalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Gata3_(Periacqueductal_gray_(PAG)_(or_adjacent_APTD))|Thalamus / BrainAtlas - Mouse McCarroll V32

RSPO2 SLC12A1

5.03e-0457262309b3d48bfe215d7b581722c06d444b5b2ef6a30
ToppCellCerebellum-Macroglia-ASTROCYTE-Gja1-Gfap-_astrocytes_(Htra1)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

C20orf173 GASK1A

7.36e-046926254e5ede00ce2920158d1cc0ac8e718aa24a4342e
ToppCellCerebellum-Macroglia-ASTROCYTE-Gja1-Gfap-_astrocytes_(Htra1)|Cerebellum / BrainAtlas - Mouse McCarroll V32

C20orf173 GASK1A

7.36e-0469262c93a47ee777b560f69b705d5d597f3cb3a3f558a
ToppCellCerebellum-Macroglia-ASTROCYTE-Gja1-Gfap-_astrocytes_(Htra1)--|Cerebellum / BrainAtlas - Mouse McCarroll V32

C20orf173 GASK1A

7.36e-04692628946d7e433c232c56563a6c464152c0a8cdbdf92
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Dlk1_(Zona_Incerta,_ventral_part_(ZIV)_and/or_Lateral_hypothalamus_(LH))-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

SLC12A1 CRB1

8.23e-0473262cfb3d5bbb1d2b6d228c2cfbdc14e6f70860fe1f2
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Calb2_(MGE-derived_cortical_interneurons--Martinotti_cells)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PAPPA BTNL9

8.23e-04732628e8d06bd4404fe6fda753e7adedc2f2150524750
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Dlk1_(Zona_Incerta,_ventral_part_(ZIV)_and/or_Lateral_hypothalamus_(LH))--|Entopeduncular / BrainAtlas - Mouse McCarroll V32

SLC12A1 CRB1

8.23e-047326223e4ed235e75c7cf2807bd0dda56be7744d0fca0
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Dlk1_(Zona_Incerta,_ventral_part_(ZIV)_and/or_Lateral_hypothalamus_(LH))|Entopeduncular / BrainAtlas - Mouse McCarroll V32

SLC12A1 CRB1

8.23e-047326293f1a39aeb4859c2d7c821ce0ebafb7b7a9d81d4
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Calb2_(MGE-derived_cortical_interneurons--Martinotti_cells)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

PAPPA BTNL9

8.23e-047326248a499fa03d736310d09b01c8889db5288e9b2da
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Six3-Inhibitory_Neuron.Gad1Gad2.Six3-Pvalb_(Thalamic_reticular_nucleus,_TRN+)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

RSPO2 PAPPA

8.91e-047626214350e0e8fc43531f33f6ed4e583e94a13d1dde5
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Six3|Entopeduncular / BrainAtlas - Mouse McCarroll V32

RSPO2 PAPPA

8.91e-0476262492cdcbc577a9334af8e4ded469da17bc7e79025
ToppCellEntopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Six3-Inhibitory_Neuron.Gad1Gad2.Six3-Pvalb_(Thalamic_reticular_nucleus,_TRN+)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

RSPO2 PAPPA

8.91e-0476262539f0076d0571be049c35541a3b281f86ddbecd6
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Trh_(Substantia_Innominata_(SI))--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SLC12A1 CRB1

1.04e-038226215bc417aaace2b1d680904a622fe76e95083c9ff
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Trh_(Substantia_Innominata_(SI))|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SLC12A1 CRB1

1.04e-0382262697e1da3095c8483b8181b290fa5417bdc9cee54
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Trh_(Substantia_Innominata_(SI))-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SLC12A1 CRB1

1.04e-038226273349906bcc8d1a40dc03df7a490a963e85564f2
ToppCelldroplet-Skin-nan-18m-Epithelial|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSPO2 CD248

2.27e-031222628f675dc341b3f6e22f7e52c34d167d9e37df0982
ToppCelldroplet-Skin-nan-18m-Epithelial-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSPO2 CD248

2.27e-03122262c7e81504e62d132624ec15b7d38dc5b6493a37a4
ToppCelldroplet-Skin-nan-18m|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSPO2 CD248

2.38e-031252625a309ce803d2b8efd791eb21808121bf5fc3ea8e
Drugpenam

CD248 MITD1

2.42e-057252CID009548842
DrugS-2-aminoethyl-L-cysteine

SAT2 CD248

2.42e-057252CID000020049
DrugAC1L1E5Z

CD248 MITD1

4.15e-059252CID000002655
DrugAC1L1G72

LAMA5 LAMA1

6.33e-0511252CID000003553
Diseaseretinitis pigmentosa (implicated_via_orthology)

CRB2 CRB1

2.02e-0427232DOID:10584 (implicated_via_orthology)
Diseaseneuroimaging measurement, brain volume measurement

RSPO2 PAPPA CRB2

1.38e-03286233EFO_0004346, EFO_0006930
DiseaseIntellectual Disability

GRIN2D DLL1 LAMA1

4.88e-03447233C3714756
Diseaseepilepsy (implicated_via_orthology)

GRIN2D SLC12A1

7.11e-03163232DOID:1826 (implicated_via_orthology)
DiseaseCOVID-19, mortality

GRIN2D ZNF316

7.71e-03170232EFO_0004352, MONDO_0100096

Protein segments in the cluster

PeptideGeneStartEntry
ALCAYFRPRAHDGGE

BTNL9

481

Q6UXG8
GYSCHCRLGFRPAED

CD248

291

Q9HCU0
FFGDRCRFLHDVGRY

DUS3L

136

Q96G46
DGDLFCARCFREGHD

ZFYVE19

436

Q96K21
EGFLGEYCQHRDPCE

NOTCH2NLA

16

Q7Z3S9
LADRYECHCPLGYAG

CRB2

126

Q5IJ48
FEGATCDRCAPGYFH

LAMA5

566

O15230
FNCIDEPSRCYFHDG

PAPPA

981

Q13219
EGFLGEYCQHRDPCE

NOTCH2NLC

16

P0DPK4
VHDRLDRYCCGFEPE

GASK1A

431

Q9UFP1
FCRPRDDAFGHFTCG

DLL1

191

O00548
EECGFLLHFRDGCYH

FSCN3

176

Q9NQT6
CPAGYAGRFCEIDHD

CRB1

136

P82279
HFDFYCGTCVLLGRP

C20orf173

76

Q96LM9
LRADGFGDNPFYHCL

SAT2

41

Q96F10
LEDFAFRGCPHVLGY

RUNDC1

126

Q96C34
FSLGYCDFDLRPCHE

MITD1

221

Q8WV92
DHDFRCDACLLGYEG

LAMA1

1471

P25391
CGLGYDFSRCRHEPC

SLC12A1

461

Q13621
HYLDAVRDGCPGLCF

TENM1

756

Q9UKZ4
GFYLHRGRCFDECPD

RSPO2

116

Q6UXX9
DRCFRCGEEGHLSPY

ZCCHC3

351

Q9NUD5
ERPYRCAFCGAGFGR

ZNF316

426

A6NFI3
CGRFAACGAEDRHAY

WDR27

766

A2RRH5
PYLCGECGEDFSEHR

ZNF202

536

O95125
RDYGFLPELGHDCRA

GRIN2D

336

O15399