Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessprotein localization to organelle

USP36 TNIK FLNA SP100 GAK MID2 DISC1 CD2AP BAG4 TOPBP1 VPS54 CBL TERF1 KIAA0753 CEP350 FSIP2 NF1 EGF MDC1 LRRC7

4.69e-06109112020GO:0033365
GeneOntologyBiologicalProcessplasma membrane bounded cell projection assembly

TNIK FLNA DISC1 CD2AP BAG4 KIAA0753 CEP350 TBC1D16 FSIP2 CFAP97D1 ARHGAP44 DNAI4 COBL WDR90 KIT

8.14e-0667012015GO:0120031
GeneOntologyBiologicalProcesscell projection assembly

TNIK FLNA DISC1 CD2AP BAG4 KIAA0753 CEP350 TBC1D16 FSIP2 CFAP97D1 ARHGAP44 DNAI4 COBL WDR90 KIT

1.06e-0568512015GO:0030031
GeneOntologyBiologicalProcessregulation of plasma membrane bounded cell projection organization

TNIK SEMA6C FLNA ARHGAP32 GAK DISC1 USH1C ZEB2 TBC1D16 NF1 ARHGAP44 PAK2 COBL LRRC7 ULK1 KIT

3.20e-0584612016GO:0120035
GeneOntologyBiologicalProcessregulation of cell projection organization

TNIK SEMA6C FLNA ARHGAP32 GAK DISC1 USH1C ZEB2 TBC1D16 NF1 ARHGAP44 PAK2 COBL LRRC7 ULK1 KIT

4.06e-0586312016GO:0031344
GeneOntologyBiologicalProcessneuron projection development

TNIK SEMA6C FLNA ARHGAP32 GAK TRIO DISC1 CD2AP SLITRK4 ARFGEF1 VPS54 USH1C ZEB2 NF1 ARHGAP44 SEC24B PAK2 COBL LRRC7 ULK1

5.00e-05128512020GO:0031175
GeneOntologyBiologicalProcessregulation of neuron projection development

TNIK SEMA6C FLNA ARHGAP32 GAK DISC1 ZEB2 NF1 ARHGAP44 PAK2 COBL LRRC7 ULK1

5.83e-0561212013GO:0010975
GeneOntologyBiologicalProcesscell morphogenesis

TNIK SEMA6C FLNA ARHGAP32 TRIO DISC1 CD2AP SLITRK4 VPS54 USH1C JMJD1C ZEB2 ARHGAP44 SEC24B PAK2 COBL ULK1 KIT YTHDF2

5.88e-05119412019GO:0000902
GeneOntologyBiologicalProcesscollateral sprouting

CD2AP ZEB2 COBL ULK1

6.20e-05371204GO:0048668
GeneOntologyBiologicalProcessactin cytoskeleton organization

TNIK FLNA MYO5A MYO7B CD2AP BAG4 ARFGEF1 USH1C SPECC1 ZEB2 NF1 ARHGAP44 PAK2 COBL KIT

6.62e-0580312015GO:0030036
GeneOntologyBiologicalProcessneural precursor cell proliferation

FLNA GAK DISC1 ZEB2 NCOR2 NF1 EGF VCAN

6.67e-052331208GO:0061351
GeneOntologyBiologicalProcessregulation of nervous system development

TNIK SEMA6C ARHGAP32 DISC1 SLITRK4 ZEB2 NF1 VCAN ULK1 SPEN KIT YTHDF2 ADGRL3

7.21e-0562512013GO:0051960
GeneOntologyBiologicalProcessactin filament-based process

TNIK FLNA MYO5A MYO7B CD2AP BAG4 ARFGEF1 USH1C SPECC1 ZEB2 NF1 ARHGAP44 PAK2 COBL CACNA1G KIT

7.80e-0591212016GO:0030029
GeneOntologyBiologicalProcessmelanocyte migration

ZEB2 KIT

1.00e-0431202GO:0097324
GeneOntologyBiologicalProcesspositive regulation of neural precursor cell proliferation

FLNA GAK DISC1 EGF VCAN

1.04e-04801205GO:2000179
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

TNIK SEMA6C ARHGAP32 TRIO DISC1 CD2AP SLITRK4 USH1C ZEB2 ARHGAP44 SEC24B PAK2 COBL ULK1

1.15e-0474812014GO:0048667
GeneOntologyBiologicalProcesspositive regulation of cellular component organization

UNC13B TNIK FLNA ARHGAP32 DISC1 BAG4 SLITRK4 CBL FASLG TERF1 ZEB2 NF1 EGF BTK COBL LRRC7 ULK1 MERTK KIT ADGRL3

1.16e-04136612020GO:0051130
GeneOntologyBiologicalProcessregulation of neural precursor cell proliferation

FLNA GAK DISC1 NF1 EGF VCAN

1.39e-041351206GO:2000177
GeneOntologyBiologicalProcessregulation of small GTPase mediated signal transduction

ARHGAP32 TRIO CD2AP ARFGEF1 CBL MADD NF1 RASAL3 ARHGAP44

1.45e-043331209GO:0051056
GeneOntologyBiologicalProcessregulation of neurogenesis

TNIK SEMA6C ARHGAP32 DISC1 ZEB2 NF1 VCAN ULK1 SPEN KIT YTHDF2

2.12e-0451512011GO:0050767
GeneOntologyBiologicalProcesspositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

BAG4 ARFGEF1 CBL EGF MERTK KIT PIK3R5

2.82e-042171207GO:0051897
GeneOntologyBiologicalProcessneuron development

TNIK SEMA6C FLNA ARHGAP32 GAK TRIO DISC1 CD2AP SLITRK4 ARFGEF1 VPS54 USH1C ZEB2 NF1 ARHGAP44 SEC24B PAK2 COBL LRRC7 ULK1

2.88e-04146312020GO:0048666
GeneOntologyBiologicalProcess4-nitrophenol metabolic process

CYP2E1 SULT1A1

3.32e-0451202GO:0018960
GeneOntologyBiologicalProcessviral transcription

SP100 MID2 RRP1B CHD1

3.63e-04581204GO:0019083
GeneOntologyBiologicalProcessprotein localization to microtubule cytoskeleton

MID2 DISC1 KIAA0753 CEP350

3.87e-04591204GO:0072698
GeneOntologyBiologicalProcessphosphatidylinositol 3-kinase/protein kinase B signal transduction

CD2AP BAG4 ARFGEF1 CBL NF1 EGF MERTK KIT PIK3R5

4.00e-043821209GO:0043491
GeneOntologyCellularComponentactin cytoskeleton

FLNA ARHGAP32 MYO5A MYO7B CD2AP APC2 TOPBP1 C10orf90 SPECC1 INTS6 SH3PXD2A COBL LRRC7

3.55e-0557612313GO:0015629
GeneOntologyCellularComponentfibrillar center

ARHGAP32 SELENBP1 CD2AP TERF1 SPECC1 NUFIP1 KIT

3.88e-051561237GO:0001650
GeneOntologyCellularComponentanchoring junction

FLNA GAK THEMIS PNN CD2AP LCP2 MAST2 CBL SH3PXD2A PI4KA MDC1 PAK2 NHS LRRC7 KIT ADGRL3 SYMPK

5.82e-0597612317GO:0070161
GeneOntologyCellularComponentnuclear protein-containing complex

FLNA SP100 PMS2 THEMIS PNN TOPBP1 ARFGEF1 BRMS1L BCOR TERF1 JMJD1C NUFIP1 NCOR2 GTF2E1 INTS6 DBF4 ASCC2 KMT2A SRRM2 SYMPK

1.53e-04137712320GO:0140513
GeneOntologyCellularComponentactin filament

FLNA MYO5A CD2AP APC2 SPECC1 COBL

2.28e-041461236GO:0005884
GeneOntologyCellularComponentcell-cell junction

FLNA THEMIS PNN CD2AP LCP2 PAK2 NHS LRRC7 KIT ADGRL3 SYMPK

7.43e-0459112311GO:0005911
GeneOntologyCellularComponentnuclear body

USP36 SP100 PNN KAT6A TOPBP1 TERF1 NCOR2 DBF4 SETBP1 MDC1 ASCC2 NHS SRRM2 SYMPK

8.69e-0490312314GO:0016604
HumanPhenoAnteverted ears

KAT6A BCOR NHS CACNA1G

4.15e-0614434HP:0040080
HumanPhenoAbnormality of pigmentation

FLNA PMS2 SLC29A3 COPB1 MYO5A APC2 KAT6A USH1C CBL JMJD1C ZEB2 ZNF469 NF1 BTK SETBP1 SPEN KIT

5.01e-066254317HP:0200045
HumanPhenoAbnormal nasal tip morphology

FLNA TRIO KAT6A BCOR JMJD1C ZEB2 MADD KIAA0753 NF1 SETBP1 KMT2A SRRM2 SPEN

9.96e-063864313HP:0000436
HumanPhenoLarge face

FLNA MID2 APC2 KAT6A BCOR JMJD1C KIAA0753 NF1 SETBP1 NHS SPEN

1.49e-052834311HP:0100729
HumanPhenoDilatation of the renal pelvis

FLNA APC2 KAT6A BCOR CBL ZEB2 KIAA0753 NF1 PI4KA SETBP1 SPEN

1.88e-052904311HP:0010946
HumanPhenoAbnormal renal pelvis morphology

FLNA APC2 KAT6A BCOR CBL ZEB2 KIAA0753 NF1 PI4KA SETBP1 SPEN

2.59e-053004311HP:0010944
HumanPhenoAbnormality of skin pigmentation

FLNA PMS2 SLC29A3 COPB1 MYO5A APC2 KAT6A CBL JMJD1C ZEB2 NF1 BTK SETBP1 SPEN KIT

2.82e-055614315HP:0001000
HumanPhenoAbnormal pulmonary valve morphology

FLNA SLC29A3 KAT6A BCOR CBL JMJD1C ZEB2 ZNF469 NF1

3.02e-05198439HP:0001641
HumanPhenoHighly arched eyebrow

TRIO KAT6A BCOR CBL ZEB2 MADD KIAA0753 KMT2A SPEN

4.13e-05206439HP:0002553
HumanPhenoStrabismus

FLNA MID2 TRIO MYO5A APC2 KAT6A BCOR CBL JMJD1C ZEB2 MADD KIAA0753 NF1 PI4KA SETBP1 PAK2 KMT2A NHS CACNA1G SRRM2 SPEN PIK3R5

4.15e-0511594322HP:0000486
HumanPhenoLong face

MID2 APC2 KAT6A BCOR JMJD1C KIAA0753 NF1 SETBP1 NHS SPEN

4.19e-052594310HP:0000276
HumanPhenoPatent ductus arteriosus

FLNA SLC29A3 TRIO APC2 KAT6A BCOR CBL JMJD1C ZEB2 PAK2 KMT2A SPEN

4.82e-053824312HP:0001643
HumanPhenoNeoplasm by histology

FLNA PMS2 APC2 FASLG SSX2 ZEB2 KIAA0753 NF1 SETBP1 PAK2 SPEN KIT

4.95e-053834312HP:0011792
HumanPhenoAbnormal hallux morphology

FLNA SLC29A3 KAT6A BCOR ZEB2 KIAA0753 ZNF469 SETBP1 KMT2A

5.19e-05212439HP:0001844
HumanPhenoAbnormal eyebrow morphology

SLC29A3 TRIO MYO5A KAT6A CHD1 BCOR CBL ZEB2 MADD KIAA0753 NF1 PI4KA SETBP1 KMT2A SPEN KIT

6.08e-056744316HP:0000534
HumanPhenoAbnormal conjugate eye movement

FLNA MID2 TRIO MYO5A APC2 KAT6A BCOR CBL JMJD1C ZEB2 MADD KIAA0753 NF1 PI4KA SETBP1 PAK2 KMT2A NHS CACNA1G SRRM2 SPEN PIK3R5

7.13e-0511984322HP:0000549
HumanPhenoTeratoma

APC2 SETBP1 KIT

8.82e-0511433HP:0009792
HumanPhenoAbnormality of the chin

FLNA TRIO APC2 KAT6A CHD1 ZEB2 MADD SETBP1 NHS CACNA1G SRRM2 SPEN

9.42e-054094312HP:0000306
HumanPhenoAbnormal hair morphology

FLNA SLC29A3 COPB1 TRIO MYO5A APC2 KAT6A CHD1 BCOR CBL JMJD1C ZEB2 MADD KIAA0753 ZNF469 NF1 PI4KA BTK SETBP1 PAK2 KMT2A CACNA1G SPEN KIT

1.07e-0414244324HP:0001595
HumanPhenoMyeloid leukemia

CBL NF1 SETBP1 KIT

1.17e-0431434HP:0012324
HumanPhenoPointed chin

FLNA KAT6A CHD1 ZEB2 MADD SETBP1 SPEN

1.31e-04138437HP:0000307
HumanPhenoLong philtrum

FLNA TRIO BCOR CBL JMJD1C MADD KIAA0753 NF1 SETBP1 KMT2A SPEN KIT

1.49e-044294312HP:0000343
HumanPhenoAbnormality of the philtrum

FLNA MID2 TRIO KAT6A BCOR CBL JMJD1C ZEB2 MADD KIAA0753 NF1 SETBP1 KMT2A SRRM2 SPEN KIT

1.51e-047264316HP:0000288
HumanPhenoOverlapping fingers

FLNA MADD PI4KA SETBP1

1.91e-0435434HP:0010557
HumanPhenoAbnormal enteric ganglion morphology

APC2 BCOR JMJD1C ZEB2 KIAA0753 SETBP1 KIT

2.21e-04150437HP:0004362
HumanPhenoAganglionic megacolon

APC2 BCOR JMJD1C ZEB2 KIAA0753 SETBP1 KIT

2.21e-04150437HP:0002251
HumanPhenoMegacolon

APC2 BCOR JMJD1C ZEB2 KIAA0753 SETBP1 KIT

2.21e-04150437HP:6000852
HumanPhenoAbnormal autonomic nervous system morphology

APC2 BCOR JMJD1C ZEB2 KIAA0753 SETBP1 KIT

2.30e-04151437HP:0012331
HumanPhenoAbnormal enteric nervous system morphology

APC2 BCOR JMJD1C ZEB2 KIAA0753 SETBP1 KIT

2.30e-04151437HP:0025028
HumanPhenoAbnormal hair pattern

FLNA SLC29A3 COPB1 TRIO APC2 CBL ZEB2 MADD KIAA0753 NF1 SETBP1 KMT2A CACNA1G SPEN KIT

2.47e-046764315HP:0010720
HumanPhenomacules

PMS2 COPB1 CBL JMJD1C ZEB2 NF1 BTK SETBP1 KIT

2.65e-04262439HP:0200031
HumanPhenoPectus excavatum

FLNA TRIO APC2 KAT6A BCOR CBL ZEB2 NF1 PI4KA KMT2A

2.67e-043234310HP:0000767
HumanPhenoHydronephrosis

FLNA APC2 KAT6A BCOR ZEB2 KIAA0753 NF1 SETBP1 SPEN

2.80e-04264439HP:0000126
HumanPhenoAbnormal eyelid morphology

FLNA SLC29A3 COPB1 TRIO MYO5A APC2 KAT6A CHD1 BCOR CBL JMJD1C ZEB2 MADD KIAA0753 ZNF469 NF1 SETBP1 PAK2 KMT2A CACNA1G SRRM2 SPEN KIT

2.89e-0414084323HP:0000492
HumanPhenoAbnormal helix morphology

FLNA TRIO KAT6A BCOR CBL JMJD1C NF1 SETBP1

3.24e-04212438HP:0011039
HumanPhenoEpicanthus

FLNA TRIO KAT6A CBL JMJD1C ZEB2 MADD KIAA0753 ZNF469 NF1 PAK2 KMT2A SRRM2 SPEN

3.25e-046144314HP:0000286
HumanPhenoAbnormal nasal septum morphology

TRIO KAT6A ZEB2 MADD NF1 KMT2A

3.58e-04115436HP:0000419
HumanPhenoAbnormal pulmonary valve physiology

FLNA SLC29A3 KAT6A BCOR ZEB2 ZNF469 NF1

3.68e-04163437HP:0031654
HumanPhenoAbnormal sternum morphology

FLNA TRIO APC2 KAT6A BCOR CBL ZEB2 KIAA0753 NF1 PI4KA SETBP1 KMT2A

3.83e-044744312HP:0000766
HumanPhenoBroad hallux

FLNA BCOR ZEB2 KIAA0753 SETBP1

4.00e-0476435HP:0010055
HumanPhenoSacrococcygeal teratoma

APC2 SETBP1

4.13e-044432HP:0030736
HumanPhenoAbnormality of refraction

FLNA MYO5A APC2 KAT6A USH1C ZEB2 MADD KIAA0753 ZNF469 VCAN SETBP1 PAK2 CACNA1G SRRM2 SPEN

4.20e-047094315HP:0000539
HumanPhenoSyndactyly

FLNA TRIO APC2 KAT6A BMS1 BCOR ZEB2 KIAA0753 SETBP1 KMT2A CACNA1G

5.03e-044174311HP:0001159
HumanPhenoAbnormal intestine morphology

FLNA PMS2 SLC29A3 COPB1 TRIO CD2AP APC2 KAT6A BCOR CBL FASLG JMJD1C ZEB2 MADD KIAA0753 PI4KA BTK SETBP1 PAK2 KMT2A CACNA1G SPEN KIT

5.10e-0414594323HP:0002242
HumanPhenoLocalized skin lesion

FLNA PMS2 SLC29A3 COPB1 KAT6A BMS1 BCOR CBL JMJD1C ZEB2 ZNF469 NF1 BTK SETBP1 KMT2A SPEN KIT

5.54e-048974317HP:0011355
HumanPhenoMidface retrusion

FLNA TRIO KAT6A CHD1 CBL NF1 SETBP1 PAK2 SPEN

5.76e-04291439HP:0011800
HumanPhenoHypertrichosis

FLNA SLC29A3 COPB1 TRIO ZEB2 KIAA0753 SETBP1 KMT2A CACNA1G SPEN KIT

5.92e-044254311HP:0000998
HumanPhenoDownslanted palpebral fissures

FLNA SLC29A3 TRIO APC2 CHD1 CBL JMJD1C ZEB2 NF1 SETBP1 KMT2A SPEN

5.92e-044974312HP:0000494
HumanPhenoFlushing

APC2 CBL NF1 KIT

6.03e-0447434HP:0031284
HumanPhenoGlioma

PMS2 APC2 NF1 SETBP1

6.54e-0448434HP:0009733
HumanPhenoPes planus

FLNA SLC29A3 COPB1 TRIO APC2 KAT6A ZEB2 ZNF469 KMT2A SPEN

7.11e-043654310HP:0001763
HumanPhenoDiagnostic behavioral phenotype

TRIO APC2 KAT6A CHD1 BCOR USH1C JMJD1C MADD NF1 SETBP1 PAK2 KMT2A NHS SRRM2 SPEN

7.42e-047474315HP:0025783
HumanPhenoBroad toe

FLNA BCOR ZEB2 KIAA0753 SETBP1

7.48e-0487435HP:0001837
HumanPhenoDelayed eruption of teeth

FLNA SLC29A3 TRIO APC2 BCOR ZEB2 SETBP1

7.90e-04185437HP:0000684
HumanPhenoToe syndactyly

FLNA TRIO APC2 KAT6A BMS1 BCOR KIAA0753 KMT2A

8.32e-04244438HP:0001770
HumanPhenoShort attention span

TNIK PMS2 TRIO APC2 CBL JMJD1C MADD NF1 SETBP1 KMT2A SRRM2 SPEN

8.47e-045174312HP:0000736
HumanPhenoAbnormal large intestine morphology

PMS2 COPB1 TRIO APC2 BCOR FASLG JMJD1C ZEB2 KIAA0753 PI4KA SETBP1 CACNA1G KIT

8.49e-045944313HP:0002250
HumanPhenoAutistic behavior

TRIO APC2 KAT6A CHD1 BCOR JMJD1C MADD NF1 SETBP1 PAK2 KMT2A NHS SRRM2 SPEN

9.04e-046784314HP:0000729
HumanPhenoAbnormal earlobe morphology

KAT6A JMJD1C ZEB2 SETBP1 SRRM2 SPEN

9.11e-04137436HP:0000363
HumanPhenoPulmonic stenosis

SLC29A3 KAT6A BCOR ZEB2 ZNF469 NF1

9.47e-04138436HP:0001642
HumanPhenoDelayed speech and language development

TNIK FLNA COPB1 TRIO APC2 KAT6A ARFGEF1 CBL ZEB2 MADD KIAA0753 NF1 PI4KA BTK SETBP1 KMT2A CACNA1G SRRM2 SPEN

9.56e-0411234319HP:0000750
HumanPhenoAbnormality of the dentition

FLNA SLC29A3 TRIO APC2 KAT6A BCOR USH1C JMJD1C ZEB2 MADD KIAA0753 ZNF469 NF1 SETBP1 PAK2 KMT2A NHS SPEN

9.58e-0410304318HP:0000164
HumanPhenoNeuroepithelial neoplasm

PMS2 APC2 NF1 SETBP1 SPEN

9.65e-0492435HP:0030063
HumanPhenoReduced attention regulation

TNIK PMS2 TRIO APC2 CBL JMJD1C MADD NF1 SETBP1 KMT2A SRRM2 SPEN

9.88e-045264312HP:5200044
HumanPhenoAbnormal serum mast cell beta-tryptase concentration

CBL KIT

1.02e-036432HP:0031900
HumanPhenoElevated total serum tryptase

CBL KIT

1.02e-036432HP:0031901
HumanPhenoUpper eyelid edema

SLC29A3 KAT6A

1.02e-036432HP:0012724
HumanPhenoCongenital malformation of the great arteries

FLNA SLC29A3 TRIO APC2 KAT6A BCOR CBL JMJD1C ZEB2 PAK2 KMT2A SPEN

1.04e-035294312HP:0011603
HumanPhenoShort philtrum

MID2 TRIO KAT6A JMJD1C ZEB2 MADD SETBP1 SPEN

1.06e-03253438HP:0000322
HumanPhenoNeuroectodermal neoplasm

PMS2 APC2 NF1 SETBP1 SPEN

1.06e-0394435HP:0030061
HumanPhenoNervous tissue neoplasm

PMS2 APC2 NF1 SETBP1 SPEN

1.06e-0394435HP:0030060
HumanPhenoNeoplasm of the nervous system

PMS2 APC2 KIAA0753 NF1 SETBP1 SPEN KIT

1.08e-03195437HP:0004375
HumanPhenoAstrocytoma

PMS2 APC2 NF1

1.13e-0325433HP:0009592
HumanPhenoSandal gap

FLNA TRIO KAT6A BCOR SETBP1

1.17e-0396435HP:0001852
HumanPhenoDental crowding

TRIO BCOR ZEB2 MADD SETBP1 SPEN

1.18e-03144436HP:0000678
HumanPhenoAbnormal bleeding

FLNA PMS2 BMS1 BCOR LCP2 CBL FASLG JMJD1C ZEB2 ZNF469 NF1 KIT

1.19e-035374312HP:0001892
HumanPhenoAbnormal columella morphology

TRIO KAT6A ZEB2 MADD KMT2A

1.23e-0397435HP:0009929
HumanPhenoAtrial septal defect

FLNA SLC29A3 TRIO APC2 KAT6A BCOR CBL JMJD1C ZEB2 NF1 SETBP1 KMT2A

1.27e-035414312HP:0001631
HumanPhenoAbnormality of the atrial septum

FLNA SLC29A3 TRIO APC2 KAT6A BCOR CBL JMJD1C ZEB2 NF1 SETBP1 KMT2A

1.27e-035414312HP:0001630
HumanPhenoNarrow palate

FLNA COPB1 APC2 BCOR MADD SETBP1 SPEN

1.33e-03202437HP:0000189
HumanPhenoAbnormal atrial septum morphology

FLNA SLC29A3 TRIO APC2 KAT6A BCOR CBL JMJD1C ZEB2 NF1 SETBP1 KMT2A

1.33e-035444312HP:0011994
HumanPhenoAbnormal anterior eye segment morphology

FLNA SLC29A3 COPB1 MYO5A APC2 KAT6A BCOR USH1C CBL JMJD1C ZEB2 KIAA0753 ZNF469 NF1 VCAN BTK SETBP1 PAK2 NHS MERTK SPEN KIT

1.34e-0314504322HP:0004328
HumanPhenoMalignant neoplasm of the central nervous system

PMS2 APC2 NF1 SETBP1 SPEN

1.34e-0399435HP:0100836
HumanPhenoHyperpigmentation of the skin

PMS2 SLC29A3 COPB1 MYO5A APC2 CBL NF1 SETBP1 KIT

1.36e-03328439HP:0000953
HumanPhenoAbnormality of the palpebral fissures

FLNA SLC29A3 COPB1 TRIO APC2 CHD1 BCOR CBL JMJD1C ZEB2 MADD NF1 SETBP1 KMT2A CACNA1G SPEN

1.39e-038804316HP:0008050
HumanPhenoGeneralized hypertrichosis

SETBP1 KMT2A

1.42e-037432HP:0004554
HumanPhenoHyperpigmented papule

FLNA KIT

1.42e-037432HP:0025473
HumanPhenoConstipation

FLNA PMS2 TRIO APC2 JMJD1C ZEB2 MADD PAK2 KMT2A SPEN KIT

1.42e-034724311HP:0002019
MousePhenoabnormal spleen size

BICDL2 SLC29A3 GAK SELENBP1 MID2 CD2AP BAG4 KAT6A CBL FASLG NCOR2 ZSCAN10 SULT1A1 VCAN BTK MDC1 SEC24B ASCC2 KMT2A ULK1 MERTK KIT

1.96e-0512039722MP:0002224
MousePhenoabnormal ear pigmentation

MYO5A CBL NF1 KIT

2.90e-0526974MP:0000015
MousePhenoabnormal thymus morphology

PMS2 SLC29A3 GAK THEMIS SELENBP1 CD2AP BAG4 KAT6A LCP2 CBL FASLG SULT1A1 SH3PXD2A MDC1 COBL KIT

3.14e-057179716MP:0000703
MousePhenoabnormal outer ear skin morphology

MYO5A CBL NF1 KIT

3.38e-0527974MP:0030530
MousePhenoabnormal foot pigmentation

MYO5A CBL NF1 KIT

3.93e-0528974MP:0009379
MousePhenoliver hypoplasia

KAT6A NF1 SH3PXD2A KMT2A SPEN

6.86e-0562975MP:0000600
MousePhenoabnormal head skin morphology

MYO5A CBL NF1 KIT

8.61e-0534974MP:0030529
MousePhenoabnormal positive T cell selection

THEMIS LCP2 CD74

1.12e-0414973MP:0004919
MousePhenoabnormal lymphopoiesis

PMS2 THEMIS KAT6A LCP2 CBL FASLG BTK MDC1 KMT2A CD74 SPEN KIT

1.43e-044909712MP:0002401
MousePhenoabnormal tail pigmentation

MYO5A CBL NF1 KIT

1.49e-0439974MP:0005174
MousePhenoabnormal outer ear morphology

MYO5A CBL NF1 KMT2A TSHZ1 KIT

1.76e-04119976MP:0002177
MousePhenolethality throughout fetal growth and development

FLNA TRIO KAT6A CBL NCOR2 NF1 VCAN SEC24B KMT2A SPEN KIT

2.09e-044359711MP:0006208
MousePhenoabnormal leukopoiesis

PMS2 SLC29A3 THEMIS KAT6A LCP2 CBL FASLG BTK MDC1 KMT2A CD74 SPEN KIT

2.26e-045949713MP:0005460
MousePhenoabnormal prevertebral ganglion morphology

NF1 SH3PXD2A

2.83e-044972MP:0008316
MousePhenotransposition of great arteries

PNN KAT6A SH3PXD2A SEC24B

3.09e-0447974MP:0004110
MousePhenoabnormal immune system development

PMS2 SLC29A3 THEMIS KAT6A LCP2 CBL FASLG BTK MDC1 KMT2A CD74 SPEN KIT

3.22e-046169713MP:0020981
MousePhenoabnormal cardiac outflow tract development

FLNA PNN NF1 SH3PXD2A VCAN SEC24B

3.36e-04134976MP:0006126
DomainLRRC37AB_C

LRRC37A3 LRRC37A2 LRRC37A

9.79e-0741183IPR029423
DomainLRRC37AB_C

LRRC37A3 LRRC37A2 LRRC37A

9.79e-0741183PF14914
DomainLRRC37_N

LRRC37A3 LRRC37A2 LRRC37A

9.79e-0741183IPR032754
DomainLRRC37

LRRC37A3 LRRC37A2 LRRC37A

9.79e-0741183PF15779
DomainLRRC37A/B-like

LRRC37A3 LRRC37A2 LRRC37A

9.79e-0741183IPR015753
DomainBRCT

TOPBP1 DBF4 MDC1

2.21e-04191183PF00533
DomainBRCT

TOPBP1 DBF4 MDC1

3.47e-04221183SM00292
Domain-

TOPBP1 DBF4 MDC1

3.97e-042311833.40.50.10190
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

ARHGAP32 TRIO CD2AP MAST2 CBL SPECC1 MADD KIAA0753 CEP350 FSIP2 NF1 SH3PXD2A PI4KA SEC24B KMT2A COBL NHS TANC1 SRRM2 YTHDF2

3.21e-118611242036931259
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

USP36 ARHGAP32 PMS2 TRIO MYO5A RRP1B BMS1 BCOR MADD KIAA0753 CEP350 NCOR2 GTF2E1 PI4KA SEC24B NHS TANC1 SRRM2 USP1 SYMPK

1.01e-0910491242027880917
Pubmed

Analysis of the multi-copy gene family FAM90A as a copy number variant in different ethnic backgrounds.

FAM90A14 FAM90A17 FAM90A23 FAM90A8 FAM90A16

1.70e-0823124518602769
Pubmed

Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events.

FAM90A14 FAM90A17 FAM90A23 FAM90A8 FAM90A16

2.67e-0825124517684299
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

ARHGAP32 DISC1 APC2 NCOR2 ZNF469 RASAL3 SETBP1 MDC1 TSHZ1 WDR90 SPEN ADGRL3

5.01e-084301241235044719
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

USP36 FLNA PNN RRP1B CD2AP TOPBP1 CHD1 BCOR SSX2 JMJD1C NCOR2 MDC1 KMT2A SRRM2 SPEN YTHDF2 SYMPK

5.41e-089541241736373674
Pubmed

A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton.

CD2AP CBL EGF SH3PXD2A

7.45e-0812124412672817
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

FLNA GAK PNN CD2AP BCOR CBL JMJD1C MDC1 SEC24B PAK2 KMT2A SPEN SYMPK

9.13e-085491241338280479
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

GAK PNN TRIO RRP1B CHD1 CBL SPECC1 NCOR2 NF1 EGF SH3PXD2A BTK KMT2A ULK1 MERTK YTHDF2

1.65e-079101241636736316
Pubmed

Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.

LRRC37A3 LRRC37A2 LRRC37A

1.76e-074124322419166
Pubmed

Symplekin, a polyadenylation factor, prevents MOZ and MLL activity on HOXA9 in hematopoietic cells.

KAT6A KMT2A SYMPK

1.76e-074124323994619
Pubmed

A human MAP kinase interactome.

FLNA ARHGAP32 SP100 LCP2 CBL TERF1 MADD CEP350 RASAL3 BTK PAK2 COBL

1.88e-074861241220936779
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

UNC13B TNIK ZEB2 MADD SNX13 COBL LRRC7 ULK1 SRRM2 SPEN ADGRL3

2.55e-074071241112693553
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

BCOR JMJD1C ZEB2 KIAA0753 CEP350 NCOR2 SEC24B SPEN

3.44e-07184124832908313
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

UNC13B SEMA6C FLNA TRIO KAT6A MAST2 MADD TBC1D16 NCOR2 PI4KA ARHGAP44 COBL WDR90 TANC1 ULK1 SPEN SYMPK

4.29e-0711051241735748872
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

FLNA SP100 CD2AP BCOR JMJD1C NCOR2 GTF2E1 SEC24B PAK2 YTHDF2 SYMPK

6.02e-074441241134795231
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

FLNA COPB1 PNN MYO5A RRP1B BMS1 CHD1 NF1 MDC1 KMT2A SRRM2 SPEN SYMPK

6.53e-076531241322586326
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

UNC13B USP36 PNN RRP1B MAST2 JMJD1C NF1 MDC1 SRRM2 SPEN

7.34e-073611241026167880
Pubmed

Human transcription factor protein interaction networks.

ARHGAP32 ATXN7L2 COPB1 PNN MYO5A RRP1B BMS1 BRMS1L BCOR JMJD1C ZEB2 NCOR2 MDC1 SEC24B KMT2A SRRM2 SPEN YTHDF2 SYMPK

7.68e-0714291241935140242
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

FLNA ARHGAP32 CD2AP CBL SPECC1 PI4KA SEC24B VSIG10L PAK2 NHS LRRC7 TANC1

9.20e-075651241225468996
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

USP36 FLNA PNN RRP1B CEP350 NF1 KMT2A SRRM2

9.34e-07210124816565220
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

USP36 MYO5A RRP1B CD2AP BMS1 TOPBP1 CHD1 BCOR SPECC1 RBM23 INTS6 PI4KA MDC1 SEC24B ASCC2 KMT2A TANC1 SPEN MRPL9

1.53e-0614971241931527615
Pubmed

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ARHGAP32 MAST2 SNX13 KIAA0753 ULK1 ADGRL3

1.75e-0610112469872452
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

RRP1B KAT6A TOPBP1 CHD1 BCOR JMJD1C ZEB2 FSIP2 GTF2E1 MDC1 KMT2A SPEN

1.97e-066081241236089195
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

FLNA PNN MYO5A MYO7B BCOR MAST2 MDC1 SRRM2

2.10e-06234124836243803
Pubmed

TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.

RRP1B CHD1 BCOR ZEB2 SPEN YTHDF2

2.73e-06109124633554859
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

USP36 EME1 ATXN7L2 PNN RRP1B TOPBP1 BRMS1L BCOR TERF1 JMJD1C NCOR2 INTS6 MDC1 KMT2A SRRM2 SPEN SYMPK

3.65e-0612941241730804502
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

PMS2 ARFGEF1 CHD1 JMJD1C MDC1 KMT2A SRRM2 SPEN SYMPK

3.98e-06341124932971831
Pubmed

Combinatorial CRISPR screen identifies fitness effects of gene paralogues.

USP36 CDS1 GAK ARFGEF1 SEC24B KMT2A SRRM2

4.97e-06186124733637726
Pubmed

Evolutionary dynamism of the primate LRRC37 gene family.

LRRC37A3 LRRC37A2 LRRC37A

5.21e-0610124323064749
Pubmed

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.

FLNA EME1 TOPBP1 BCOR SPECC1 ZEB2 CEP350 MDC1 SYMPK

5.76e-06357124937059091
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

CDS1 MID2 TRIO MYO5A CD2AP KAT6A VPS54 SSX2 JMJD1C NCOR2 INTS6 SH3PXD2A SETBP1 ARHGAP44 COBL LRRC7 TANC1 CYP4F11

5.82e-0614891241828611215
Pubmed

Oct4 links multiple epigenetic pathways to the pluripotency network.

FLNA COPB1 JMJD1C NCOR2 GTF2E1 MDC1 SYMPK

8.80e-06203124722083510
Pubmed

Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells.

FLNA PNN CD2AP CBL PAK2 SRRM2

1.02e-05137124637039823
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

USP36 SP100 ATXN7L2 BAG4 KAT6A BRMS1L BCOR MAST2 NUFIP1 NCOR2 INTS6 ZNF469 RASAL3 TANC1 SRRM2

1.09e-0511161241531753913
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

ARHGAP32 ATXN7L2 MID2 COPB1 BEND5 KAT6A BCOR USH1C CEP350 CACNA1G SPEN

1.21e-056081241116713569
Pubmed

Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation.

LCP2 CBL

1.26e-052124219074136
Pubmed

Human CYP2E1-dependent and human sulfotransferase 1A1-modulated induction of micronuclei by benzene and its hydroxylated metabolites in Chinese hamster V79-derived cells.

CYP2E1 SULT1A1

1.26e-052124225771868
Pubmed

Solution structure of the human BTK SH3 domain complexed with a proline-rich peptide from p120cbl.

CBL BTK

1.26e-052124210826882
Pubmed

Structure of Myo7b/USH1C complex suggests a general PDZ domain binding mode by MyTH4-FERM myosins.

MYO7B USH1C

1.26e-052124228439001
Pubmed

The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function.

TNIK DISC1

1.26e-052124220838393
Pubmed

Solution structure of the second SH3 domain of human CMS and a newly identified binding site at the C-terminus of c-Cbl.

CD2AP CBL

1.26e-052124217188587
Pubmed

Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control.

TOPBP1 MDC1

1.26e-052124223891287
Pubmed

Ubiquitin-specific protease 1 acts as an oncogene and promotes lenvatinib efficacy in hepatocellular carcinoma by stabilizing c-kit.

USP1 KIT

1.26e-052124235045360
Pubmed

The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction.

CD2AP CBL

1.26e-052124211067845
Pubmed

Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation.

CBL KIT

1.26e-052124216780420
Pubmed

The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase.

CBL BTK

1.26e-05212427629518
Pubmed

Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow.

NF1 KIT

1.26e-052124218984156
Pubmed

Leukemic potential of doubly mutant Nf1 and Wv hematopoietic cells.

NF1 KIT

1.26e-052124212393498
Pubmed

Human cytochrome P450 2E1 and sulfotransferase 1A1 coexpressed in Chinese hamster V79 cells enhance spontaneous mutagenesis.

CYP2E1 SULT1A1

1.26e-052124219484729
Pubmed

CBL mutations in infant acute lymphoblastic leukaemia.

CBL KMT2A

1.26e-052124221988239
Pubmed

Feedback activation of neurofibromin terminates growth factor-induced Ras activation.

NF1 EGF

1.26e-052124226861207
Pubmed

Estradiol protects dermal hyaluronan/versican matrix during photoaging by release of epidermal growth factor from keratinocytes.

EGF VCAN

1.26e-052124222493503
Pubmed

Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link Complex.

MYO7B USH1C

1.26e-052124226812017
Pubmed

Identification of CBL, a proto-oncogene at 11q23.3, as a novel MLL fusion partner in a patient with de novo acute myeloid leukemia.

CBL KMT2A

1.26e-052124212696071
Pubmed

SH3 domain of Bruton's tyrosine kinase can bind to proline-rich peptides of TH domain of the kinase and p120cbl.

CBL BTK

1.26e-05212429408950
Pubmed

The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin.

FLNA TRIO

1.26e-052124211146652
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

FLNA PMS2 PNN RRP1B TOPBP1 CBL PAK2 NHS SRRM2 SPEN

1.37e-055031241016964243
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

UNC13B PMS2 COPB1 TRIO MYO5A APC2 VPS54 TERF1 SPECC1 ZEB2 MADD NUFIP1 CEP350 PAK2 CD74 MERTK

1.41e-0512851241635914814
Pubmed

A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.

FLNA MYO7B USH1C COBL

2.05e-0545124422114352
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

USP36 SEMA6C RRP1B BMS1 TOPBP1 BCOR SETBP1 MDC1 CACNA1G WDR90

2.11e-055291241014621295
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

FLNA EME1 PNN BCOR NCOR2 NF1 DBF4 MDC1 KMT2A SRRM2 SPEN SYMPK

2.22e-057741241215302935
Pubmed

Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.

CDS1 FAM90A14 FAM90A17 FAM90A23 MERTK FAM90A8

2.83e-05164124622967998
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

USP36 TNIK FLNA GAK COPB1 PNN CHD1 BCOR GTF2E1 SEC24B PAK2 KMT2A YTHDF2

3.07e-059341241333916271
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

MYO5A SPECC1 MADD NF1 SH3PXD2A LRRC7 SRRM2 ADGRL3

3.65e-05347124817114649
Pubmed

Oocytes can repair DNA damage during meiosis via a microtubule-dependent recruitment of CIP2A-MDC1-TOPBP1 complex from spindle pole to chromosomes.

TOPBP1 MDC1

3.77e-053124236999590
Pubmed

Impact of FLT3 mutations and promyelocytic leukaemia-breakpoint on clinical characteristics and prognosis in acute promyelocytic leukaemia.

KMT2A KIT

3.77e-053124216029447
Pubmed

Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor.

CBL EGF

3.77e-053124214627991
Pubmed

Structural insights into the recruitment of SMRT by the corepressor SHARP under phosphorylative regulation.

NCOR2 SPEN

3.77e-053124224268649
Pubmed

Mdc1 modulates the interaction between TopBP1 and the MRN complex during DNA damage checkpoint responses.

TOPBP1 MDC1

3.77e-053124227590578
Pubmed

Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo.

NF1 KIT

3.77e-053124210620616
Pubmed

CRISPR Gene Editing of Murine Blood Stem and Progenitor Cells Induces MLL-AF9 Chromosomal Translocation and MLL-AF9 Leukaemogenesis.

KMT2A KIT

3.77e-053124232549410
Pubmed

Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation.

CBL EGF

3.77e-053124215475003
Pubmed

The importance of relative mutant level for evaluating impact on outcome of KIT, FLT3 and CBL mutations in core-binding factor acute myeloid leukemia.

CBL KIT

3.77e-053124223783394
Pubmed

Forkhead box Q1 promotes hepatocellular carcinoma metastasis by transactivating ZEB2 and VersicanV1 expression.

ZEB2 VCAN

3.77e-053124224005989
Pubmed

CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl.

CD2AP CBL

3.77e-053124212559036
Pubmed

Whole-exome sequencing identifies recurrent SF3B1 R625 mutation and comutation of NF1 and KIT in mucosal melanoma.

NF1 KIT

3.77e-053124228296713
Pubmed

Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.

MYO5A KMT2A

3.77e-05312428327517
Pubmed

Disrupted-in-Schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling.

TRIO DISC1

3.77e-053124221422296
Pubmed

E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease.

CBL KIT

3.77e-053124219734451
Pubmed

A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.

BCOR NCOR2

3.77e-053124223911289
Pubmed

Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing.

LCP2 KIT

3.77e-053124217372019
Pubmed

Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer.

CHD1 KMT2A

3.77e-053124222046413
Pubmed

ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation.

MYO7B USH1C

3.77e-053124226812018
Pubmed

Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl.

CBL KIT

3.77e-053124217904548
Pubmed

Neurofibromin as a regulator of melanocyte development and differentiation.

NF1 KIT

3.77e-053124218089649
Pubmed

The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1).

CD2AP CBL

3.77e-053124215001553
Pubmed

Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl).

CBL KIT

3.77e-053124215315962
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

PMS2 TRIO CD2AP KAT6A MAST2 CBL MADD KIAA0753 NUFIP1 CEP350 SYMPK

3.81e-056891241136543142
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TNIK ARHGAP32 TRIO MYO5A APC2 BCOR ZEB2 NCOR2 NF1 PI4KA ARHGAP44 PAK2 LRRC7

4.19e-059631241328671696
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

ARHGAP32 PNN JMJD1C SEC24B NHS LRRC7 TANC1

4.63e-05263124734702444
Pubmed

Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics.

THEMIS LCP2 CBL

4.82e-0520124331591574
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

FLNA ARHGAP32 GAK SELENBP1 COPB1 TRIO MYO5A SPECC1 MADD NF1 PI4KA VCAN ARHGAP44 KMT2A LRRC7 TANC1

5.13e-0514311241637142655
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

USP36 SP100 PMS2 TRIO BMS1 CHD1 GTF2E1 TANC1 SRRM2

5.18e-05472124938943005
Pubmed

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.

SP100 TOPBP1 CHD1 JMJD1C KMT2A SPEN

5.22e-05183124636129980
Pubmed

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.

FLNA CBL FASLG EGF PAK2 CD74 KIT PIK3R5

5.84e-05371124825241761
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

USP36 FLNA MID2 MYO5A CD2AP CEP350 SH3PXD2A ASCC2 PAK2 SPEN YTHDF2

5.94e-057241241136232890
Pubmed

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.

FLNA PNN RRP1B BAG4 SEC24B COBL YTHDF2

5.99e-05274124734244482
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

TNIK GAK TRIO CHD1 JMJD1C MADD CEP350 MDC1 TANC1 USP1 YTHDF2

6.62e-057331241134672954
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

TNIK ARHGAP32 TRIO MYO5A NF1 PI4KA LRRC7

7.02e-05281124728706196
InteractionNUP43 interactions

USP36 FLNA EME1 PNN RRP1B BMS1 TOPBP1 CHD1 BCOR JMJD1C FSIP2 NCOR2 PI4KA MDC1 KMT2A SRRM2 SPEN

1.39e-0762511817int:NUP43
InteractionYWHAG interactions

FLNA ARHGAP32 COPB1 PNN DISC1 CD2AP MAST2 CBL TERF1 SPECC1 KIAA0753 CEP350 NF1 SH3PXD2A PI4KA SEC24B PAK2 KMT2A COBL NHS TANC1 ULK1 SRRM2 YTHDF2

2.03e-07124811824int:YWHAG
InteractionSH3GL2 interactions

TNIK CD2AP LCP2 MAST2 CBL TERF1 PAK2

8.46e-07881187int:SH3GL2
InteractionLYN interactions

TNIK ARHGAP32 TRIO SLITRK4 LCP2 CBL FASLG SPECC1 NF1 PI4KA BTK PAK2 KMT2A TANC1 ULK1 SRRM2 KIT

1.00e-0672011817int:LYN
InteractionYWHAH interactions

ARHGAP32 PNN TRIO CD2AP MAST2 CBL SPECC1 MADD KIAA0753 CEP350 NF1 SH3PXD2A PI4KA SEC24B PAK2 KMT2A COBL NHS TANC1 SRRM2 YTHDF2

1.54e-06110211821int:YWHAH
InteractionITK interactions

PNN LCP2 CBL FASLG BTK SRRM2

1.67e-06621186int:ITK
InteractionPML interactions

FLNA EME1 SP100 PMS2 CD2AP KAT6A TOPBP1 BCOR JMJD1C NCOR2 GTF2E1 INTS6 NF1 MDC1 SEC24B PAK2 KMT2A YTHDF2 SYMPK

1.98e-0693311819int:PML
InteractionNCK2 interactions

TNIK ARHGAP32 DISC1 LCP2 CBL FASLG C4orf17 PAK2 NHS KIT

3.30e-0626211810int:NCK2
InteractionYWHAZ interactions

ARHGAP32 COPB1 MYO5A DISC1 KAT6A BCOR LCP2 MAST2 CBL SPECC1 MADD FSIP2 NF1 RASAL3 SH3PXD2A MDC1 PAK2 KMT2A NHS CD74 TANC1 ULK1

7.30e-06131911822int:YWHAZ
InteractionBLNK interactions

CD2AP LCP2 CBL BTK KIT

8.85e-06481185int:BLNK
InteractionCRK interactions

FLNA ARHGAP32 CD2AP KAT6A BCOR CBL FASLG C4orf17 SPEN KIT ADGRL3

1.14e-0537011811int:CRK
InteractionHCK interactions

MID2 CD2AP LCP2 CBL FASLG BTK PAK2 KIT

1.82e-051931188int:HCK
InteractionSMC5 interactions

USP36 FLNA PNN RRP1B DISC1 CD2AP TOPBP1 CHD1 BCOR SSX2 JMJD1C NCOR2 MDC1 KMT2A SRRM2 SPEN YTHDF2 SYMPK

2.04e-05100011818int:SMC5
InteractionSNRNP40 interactions

USP36 FLNA PNN RRP1B KAT6A BMS1 CHD1 BCOR NUFIP1 NCOR2 MDC1 KMT2A SRRM2 SPEN

2.18e-0563711814int:SNRNP40
InteractionGRAP2 interactions

BEND5 BAG4 LCP2 CBL FASLG KIT

3.37e-051041186int:GRAP2
InteractionEN1 interactions

BRMS1L BCOR ZEB2 NCOR2 KMT2A SRRM2

4.63e-051101186int:EN1
InteractionMAPRE1 interactions

FLNA TRIO CD2AP APC2 CBL TERF1 SPECC1 CEP350 COBL WDR90 TANC1 SRRM2

4.90e-0551411812int:MAPRE1
InteractionSFN interactions

TNIK ARHGAP32 CD2AP MAST2 CBL SPECC1 CEP350 SH3PXD2A PAK2 KMT2A COBL NHS TANC1 SRRM2

5.37e-0569211814int:SFN
InteractionMAPRE3 interactions

TRIO APC2 CBL SPECC1 NUFIP1 CEP350 COBL TANC1

6.35e-052301188int:MAPRE3
InteractionGRIN2B interactions

TNIK ARHGAP32 ZEB2 NF1 LRRC7 TANC1 ADGRL3

6.45e-051701187int:GRIN2B
InteractionLCK interactions

ARHGAP32 TRIO MYO5A LCP2 CBL FASLG NF1 PI4KA PAK2 TANC1 KIT

8.79e-0546311811int:LCK
InteractionTERF2IP interactions

SP100 OGFR TOPBP1 CHD1 BCOR TERF1 NCOR2 MDC1 KMT2A SRRM2 SPEN SYMPK

9.67e-0555211812int:TERF2IP
InteractionTOP3B interactions

UNC13B SEMA6C FLNA MID2 TRIO KAT6A MAST2 MADD TBC1D16 NCOR2 PI4KA ARHGAP44 MDC1 SEC24B COBL WDR90 TANC1 ULK1 SPEN YTHDF2 SYMPK

1.17e-04147011821int:TOP3B
InteractionYWHAE interactions

FLNA ARHGAP32 DISC1 LCP2 MAST2 CBL SPECC1 NCOR2 NF1 RASAL3 SH3PXD2A PAK2 KMT2A NHS CD74 TANC1 ULK1 MERTK SRRM2

1.23e-04125611819int:YWHAE
InteractionCTBP1 interactions

TNIK PNN BCOR ZEB2 NCOR2 MDC1 KMT2A TSHZ1 SRRM2 SPEN

1.39e-0440611810int:CTBP1
InteractionDPYSL3 interactions

TNIK DISC1 CBL TERF1 NUFIP1

1.51e-04861185int:DPYSL3
InteractionTANC2 interactions

TNIK FLNA NF1 SH3PXD2A TANC1

1.77e-04891185int:TANC2
InteractionTEC interactions

FASLG BTK KMT2A MERTK KIT

1.87e-04901185int:TEC
InteractionGRAP interactions

ARHGAP32 FASLG KIT

2.07e-04201183int:GRAP
InteractionBTK interactions

FLNA CBL FASLG BTK MERTK KIT

2.13e-041451186int:BTK
InteractionFYN interactions

ARHGAP32 PMS2 CD2AP BAG4 LCP2 CBL FASLG BTK PAK2 KIT

2.25e-0443111810int:FYN
InteractionPARN interactions

USP36 BCOR JMJD1C NCOR2 MDC1 SYMPK

2.38e-041481186int:PARN
InteractionKALRN interactions

TNIK TRIO MYO5A DISC1 FASLG

2.53e-04961185int:KALRN
Cytoband8p23.1

FAM90A14 FAM90A17 FAM90A23 FAM90A8 FAM90A16

6.50e-0515412458p23.1
CytobandEnsembl 112 genes in cytogenetic band chr8p23

FAM90A14 FAM90A17 FAM90A23 FAM90A8 FAM90A16

4.53e-042341245chr8p23
GeneFamilySulfotransferases, cytosolic

SULT1B1 SULT1A1

1.13e-0314652762
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZEB2 TSHZ1

1.30e-0315652529
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

SP100 TRIO CD2AP KAT6A TOPBP1 ARFGEF1 CHD1 MAST2 TERF1 ZEB2 SNX13 CEP350 NCOR2 DBF4 SEC24B SPEN

1.70e-0685611916M4500
CoexpressionHOEBEKE_LYMPHOID_STEM_CELL_UP

PNN NCOR2 NF1 BTK SETBP1 COBL

5.44e-06971196M14698
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

FLNA THEMIS COPB1 PNN MYO5A KAT6A CHD1 LCP2 CBL FASLG JMJD1C ZEB2 CEP350 RASAL3 PAK2 KMT2A SPEN USP1 KIT PIK3R5

1.24e-05149211920M40023
CoexpressionGSE15330_LYMPHOID_MULTIPOTENT_VS_MEGAKARYOCYTE_ERYTHROID_PROGENITOR_UP

SLC29A3 TOPBP1 ZEB2 NUFIP1 INTS6 KMT2A WDR90

3.69e-052001197M7031
CoexpressionGSE5542_IFNG_VS_IFNA_TREATED_EPITHELIAL_CELLS_6H_UP

PMS2 RBKS BRMS1L KIAA0753 WDR90 MERTK USP1

3.69e-052001197M6542
CoexpressionHAMAI_APOPTOSIS_VIA_TRAIL_UP

ST6GALNAC1 PNN MYO5A ARFGEF1 CHD1 SPECC1 SNX13 CEP350 DBF4 ARHGAP44 USP1 KIT

4.53e-0565611912M18979
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

TRIO CD2AP KAT6A TOPBP1 ARFGEF1 CHD1 SNX13 CEP350 SEC24B SPEN

5.42e-0546611910M13522
CoexpressionAtlasFacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#2

EME1 GAK COPB1 TRIO KAT6A TOPBP1 ARFGEF1 VPS54 JMJD1C KIAA0753 GTF2E1 DBF4 MDC1 SEC24B

2.77e-0656411714Facebase_RNAseq_e9.5_Mandibular Arch_2500_K2
CoexpressionAtlasFacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_2500_k-means-cluster#3

EME1 SLC29A3 BEND5 LCP2 RASAL3 SH3PXD2A ASCC2 NHS CD74 CACNA1G TSHZ1 MERTK MRPL9 PIK3R5

2.94e-0656711714Facebase_RNAseq_e10.5_Olfactory Pit_2500_K3
ToppCellChildren_(3_yrs)-Immune-monocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

DISC1 LCP2 CBL SPECC1 ZEB2 VCAN MERTK PIK3R5

5.83e-081961198cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

THEMIS MYO5A LCP2 ZEB2 VCAN CD74 MERTK PIK3R5

6.06e-081971198c9b1f2ee7eb31a66af331c5aae29e1bbb5186f5a
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SP100 PNN CHD1 JMJD1C ZEB2 CEP350 KMT2A SRRM2

6.81e-08200119812f1685ce8f218433068e090c9d839cd5a1910bf
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP36 FLNA C1orf54 CDS1 MYO5A CD74 ADGRL3

2.53e-071601197e9e52532131cdc3fb01e81cfc046e3f670cc8e75
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD2AP KAT6A CHD1 JMJD1C ZEB2 CEP350 KMT2A

6.50e-0718411971154a5ad7b8512272b7476f949ddac350910bfb7
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1orf54 CD2AP KAT6A CHD1 JMJD1C ZEB2 CEP350

6.74e-0718511977adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

ARFGEF1 CHD1 JMJD1C ZEB2 NF1 KMT2A SPEN

7.51e-071881197ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DISC1 LCP2 ZEB2 BTK CD74 MERTK PIK3R5

8.64e-07192119786d792682ba51696f503c79625dd20f87bcf651f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DISC1 LCP2 ZEB2 BTK CD74 MERTK PIK3R5

8.64e-071921197d0ad6a205ad50a3c523fa68676996b289eabc5de
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD2AP KAT6A JMJD1C SNX13 CEP350 SRRM2 YTHDF2

8.95e-07193119706b65110db974f4ef90d3511ff34428976a52c9c
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD2AP KAT6A JMJD1C SNX13 CEP350 SRRM2 YTHDF2

8.95e-0719311979c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCellControl-Myeloid-Monocyte-derived_macrophages|Control / group, cell type (main and fine annotations)

MYO5A DISC1 LCP2 ZEB2 CD74 MERTK PIK3R5

8.95e-071931197a6b3bd01e585e2e3fbe9bf693a2e385773123f8e
ToppCellfacs-Brain_Myeloid-Hippocampus-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD2AP KAT6A JMJD1C SNX13 CEP350 SRRM2 YTHDF2

8.95e-071931197a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCellfacs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD2AP KAT6A JMJD1C SNX13 CEP350 SRRM2 YTHDF2

8.95e-071931197b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO5A DISC1 LCP2 ZEB2 CD74 MERTK PIK3R5

9.27e-071941197c95d5c4ad0210ebd672926558cc8331e6396a854
ToppCellChildren_(3_yrs)-Immune-monocyte-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DISC1 LCP2 SPECC1 ZEB2 VCAN MERTK PIK3R5

9.59e-07195119781a28289eda1a8a1a31b7357106f64ac5000e172
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MYO5A DISC1 LCP2 ZEB2 CD74 MERTK PIK3R5

9.59e-07195119742bfdff88da1d07828c0ad65d412fb1752f0cee4
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MYO5A DISC1 LCP2 ZEB2 CD74 MERTK PIK3R5

9.92e-071961197cbc727b55b6433a701b1a331028a49960fcee6ee
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MYO5A LCP2 ZEB2 VCAN CD74 MERTK PIK3R5

1.03e-0619711978af4a1e35ce9fb4ea3d26ab619599efb7eac43a5
ToppCellBronchial-NucSeq-Immune_Myeloid-Mast_cell-Mast_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TNIK LCP2 SPECC1 ZEB2 ZSCAN10 BTK KIT

1.03e-061971197bed8a9b73af5caee51b1232b31c24a59353658df
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THEMIS DISC1 LCP2 ZEB2 RASAL3 CD74 PIK3R5

1.03e-0619711970523aec9713ae21e6b879aa98e07fa2576610d5f
ToppCellChildren_(3_yrs)-Immune|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYO5A DISC1 LCP2 CBL ZEB2 CD74 PIK3R5

1.03e-061971197f18807124b91310fcd84238484a80ecdba684679
ToppCellBronchial-NucSeq-Immune_Myeloid-Mast_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TNIK LCP2 SPECC1 ZEB2 ZSCAN10 BTK KIT

1.03e-061971197b7d5073d44aa1e2cb83ea8d8104c5ed662665755
ToppCellnucseq-Immune-Immune_Myeloid-IM|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MYO5A DISC1 LCP2 ZEB2 TBC1D16 MERTK PIK3R5

1.03e-0619711976f41c8f815851968849428ec92c16745bd01a3fb
ToppCellnucseq-Immune-Immune_Myeloid-IM-IM|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MYO5A DISC1 LCP2 ZEB2 TBC1D16 MERTK PIK3R5

1.03e-061971197304044ace926943b8eb588f686ecbe5d1689a809
ToppCellT_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

TNIK FLNA THEMIS LCP2 FASLG RASAL3 KMT2A

1.06e-0619811971ca6cd8e75891fdfaddbb4a7342eec9ca4d11e5d
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

UNC13B ARHGAP32 TRIO LRRC37A3 NF1 ARHGAP44 TANC1

1.06e-0619811971996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYO5A DISC1 LCP2 ZEB2 CD74 MERTK PIK3R5

1.14e-062001197179afc4bee7a2fd85a3b5dadf32544a63807c164
ToppCellTracheal-NucSeq-Immune_Myeloid|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LCP2 SPECC1 ZEB2 BTK CD74 MERTK PIK3R5

1.14e-062001197ad7ae5106141669b353800fece833b3cd5bdccee
ToppCellChildren_(3_yrs)-Immune-monocyte-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

DISC1 LCP2 CBL ZEB2 VCAN MERTK PIK3R5

1.14e-062001197881ab995c90d75fd987d6e8f1f926a4bfcc4235f
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYO5A DISC1 LCP2 ZEB2 CD74 MERTK PIK3R5

1.14e-062001197ad52b38df5c71f28829b04cd0e6b97f0f9f7610a
ToppCellBronchial-NucSeq-Immune_Myeloid-Monocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DISC1 LCP2 CBL ZEB2 VCAN BTK PIK3R5

1.14e-0620011978872d5fa101d413fb43b4231d476878678543035
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intermediate|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYO5A DISC1 LCP2 ZEB2 VCAN CD74 PIK3R5

1.14e-06200119746f9c28b24e39acdf0481a02b6eb86ecdd83c504
ToppCellCOVID-19-COVID-19_Mild|COVID-19 / Disease, condition lineage and cell class

SP100 PNN CHD1 JMJD1C ZEB2 CD74 SRRM2

1.14e-06200119762c25042086f1afd1102e0720e933c2e476468fd
ToppCelldroplet-Lung-3m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC29A3 ATXN7L2 CYP2E1 DISC1 BMS1 SEC24B

5.67e-061661196de319c960b0cd90b294f677d1ea1b013a2ce2d53
ToppCell5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TNIK SLITRK4 RBM23 BTK COBL KIT

5.67e-061661196a42268a02a89fc97272e45c4cbe21acf04b7428c
ToppCellPCW_07-8.5-Immune_Lymphocytic-Immune_Lymphocytic_B-im_B_cell_(15)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

THEMIS LCP2 FASLG RASAL3 CD74 PIK3R5

6.07e-0616811962ec53f91de3bff8a106430a78b81ee6870f0c55e
ToppCell5'-Adult-SmallIntestine-Hematopoietic-T_cells-CX3CR1+_CD8_Tmem|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNA ATXN7L2 TERF1 ZEB2 ZNF469 PIK3R5

6.72e-061711196187b396059f8802265f54bad2b4882cebb809419
ToppCellCOVID-19-lung-MAST|COVID-19 / Disease (COVID-19 only), tissue and cell type

TNIK SPECC1 ZEB2 BTK COBL KIT

7.92e-061761196473c45a381ca109207d66ed1635668b391ea0e1f
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BICDL2 CD2AP ZEB2 BTK SPEN CCDC158

8.18e-06177119614fb8d182775dfd0e49aa7e4e12543a85b3b8bd6
ToppCelldroplet-Marrow-nan-3m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C1orf54 CD2AP KAT6A CHD1 ZEB2 CEP350

9.59e-061821196f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCelldroplet-Spleen-nan-18m|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 CD2AP CHD1 JMJD1C CD74 SRRM2

9.59e-061821196eeb5dfa4539e9ca5220f26bc2b65717ddcf13b6c
ToppCelldroplet-Spleen-nan-18m-Lymphocytic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 CD2AP CHD1 JMJD1C CD74 SRRM2

9.89e-06183119628cbf909424f3be4491d49832f0aca0386560814
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

SP100 TRIO OGFR CD2AP JMJD1C CEP350

9.89e-0618311968f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCelldroplet-Spleen-nan-18m-Lymphocytic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP100 CD2AP CHD1 JMJD1C CD74 SRRM2

9.89e-0618311963fa608aa6b119869ec3280dc388dfee57160e63a
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

USP36 CHD1 LCP2 JMJD1C ZEB2 VCAN

1.02e-051841196b45b1fdba13c8ed2a04a4fb3b62d8ad92785c768
ToppCellChildren_(3_yrs)-Immune-T_lymphocyte-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

SP100 THEMIS DISC1 LCP2 RASAL3 PIK3R5

1.19e-051891196df30478b288084a1bd48f660409dcc784040897c
ToppCellLV-14._Fibroblast_III|World / Chamber and Cluster_Paper

USP36 CHD1 NCOR2 SH3PXD2A VCAN CACNA1G

1.19e-0518911963922135d1f6fc768d71ba3b465585fead6ea68a8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THEMIS LCP2 FASLG ZEB2 RASAL3 PIK3R5

1.22e-0519011964a75457652d85874d5c6a41648f8003572008b15
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYO5A DISC1 LCP2 ZEB2 MERTK PIK3R5

1.22e-0519011962d54fca50593fbd11fe13fc2bfaf937a05db776d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THEMIS LCP2 FASLG ZEB2 RASAL3 PIK3R5

1.22e-051901196cda6173634531240e0bab8766231a150ff8d0129
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DISC1 LCP2 ZEB2 CD74 MERTK PIK3R5

1.26e-05191119651f5af610983aa73b9f4ece6f27d281ebff89a04
ToppCellControl-Myeloid|Control / group, cell type (main and fine annotations)

MYO5A DISC1 ZEB2 CD74 MERTK PIK3R5

1.26e-0519111969c4acc5f3c2f9c0c5520863bb22f391774372347
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DISC1 LCP2 ZEB2 BTK CD74 PIK3R5

1.26e-051911196baa70781633a3fe5bf987f9d8dff3884f5167e7f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DISC1 LCP2 ZEB2 CD74 MERTK PIK3R5

1.26e-0519111968fd6bdc9d2b1c8d364221d7bc68d03921b668ab5
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THEMIS LCP2 ZEB2 BTK KIT PIK3R5

1.26e-051911196468b5149d1533f03521844d3cce8633d44eb6ed4
ToppCellPCW_07-8.5-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_ILC3_(12)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

THEMIS CYP2E1 LCP2 FASLG RASAL3 PIK3R5

1.30e-05192119642fed1a4c88e62dffda026503e5da1eb21fe877f
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

USP36 TNIK ARFGEF1 CHD1 JMJD1C KMT2A

1.30e-05192119647646d7e4990be85072987f92bf18d52f8da752e
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)|Adult / Lineage, Cell type, age group and donor

MYO5A DISC1 LCP2 ZEB2 MERTK PIK3R5

1.34e-05193119631c0978ba78c9516d498aec0798902e57555e557
ToppCellImmune-interstitial_macrophage_(C1Q_positive)|World / Lineage, Cell type, age group and donor

MYO5A DISC1 ZEB2 CD74 MERTK PIK3R5

1.34e-05193119664d598162a256ac6c9f8280c8a9133661dfbb10f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DISC1 LCP2 ZEB2 BTK CD74 PIK3R5

1.34e-051931196f597fefc54327a1ad136e2f66b6e81cc5c761eb7
ToppCellLV-14._Fibroblast_III|LV / Chamber and Cluster_Paper

USP36 CHD1 NCOR2 SH3PXD2A VCAN CACNA1G

1.38e-051941196927c26aea0147f7a4b8fb3f192de4de263f1b978
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D231|Adult / Lineage, Cell type, age group and donor

MYO5A DISC1 LCP2 ZEB2 CD74 MERTK

1.38e-051941196800d3d7a9e864d2d6a100a4e4af22f45d5790a8d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THEMIS DISC1 LCP2 ZEB2 CD74 PIK3R5

1.38e-0519411960866ab6792cee274a71991d5c37a37f574ff446e
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

MYO5A DISC1 LCP2 ZEB2 MERTK PIK3R5

1.38e-051941196663e7e7fe48157e808b4f1a0ea6ad41944e857a2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MYO5A DISC1 LCP2 ZEB2 MERTK PIK3R5

1.38e-0519411961dce6d4b6ac41f80677e3e4c335a4f383bd76f85
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DISC1 LCP2 ZEB2 BTK CD74 PIK3R5

1.38e-051941196badefcec2af86cbcd97305f4843e84db0f3ebc66
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THEMIS DISC1 LCP2 RASAL3 BTK PIK3R5

1.42e-0519511962d485373bfd9bb4bb9236bf0b31d03e132c8018f
ToppCellCOVID-19-Myeloid-Monocyte-derived_macrophages|COVID-19 / group, cell type (main and fine annotations)

MYO5A DISC1 LCP2 ZEB2 MERTK PIK3R5

1.42e-051951196c172c5599379c29123340621a36bfb1fc90c2115
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MYO5A LCP2 ZEB2 CD74 MERTK PIK3R5

1.42e-051951196247803cf58c6d9c561a52aa34e581188ddad197e
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THEMIS DISC1 LCP2 ZEB2 RASAL3 PIK3R5

1.42e-051951196ce8215d503cad3a9bc7d5d2be4adb57408015593
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MYO5A DISC1 LCP2 ZEB2 MERTK PIK3R5

1.42e-05195119634a9462f4e843f3065cc58c17ad71c1b5b836ae1
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DISC1 LCP2 ZEB2 BTK CD74 PIK3R5

1.46e-0519611964370473693d2dd4a8c451a4c477eb79baa33ae12
ToppCellCOVID-19-lung-Macrophage_metabolically_active|lung / Disease (COVID-19 only), tissue and cell type

MYO5A LCP2 ZEB2 CD74 MERTK PIK3R5

1.46e-051961196a753d76d764c181eecb0e17a794a2e7d0ff70136
ToppCellCOVID-19-lung-Macrophage_metabolically_active|COVID-19 / Disease (COVID-19 only), tissue and cell type

MYO5A LCP2 ZEB2 CD74 MERTK PIK3R5

1.46e-0519611961b7928f4eee94d4bb6ea410bab68a471dba12979
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DISC1 LCP2 ZEB2 CD74 MERTK PIK3R5

1.50e-0519711966ca6e17b7cc5f7ea8d4b6ca1ff670969bee65a45
ToppCellCOVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi|lung / Disease (COVID-19 only), tissue and cell type

MYO5A LCP2 ZEB2 VCAN MERTK PIK3R5

1.50e-0519711963896729740d151f0eb845f1961c7b969bfbdd28d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DISC1 LCP2 SPECC1 ZEB2 CD74 PIK3R5

1.50e-05197119657dafb3047745a44b2345b8036e159c3641d496e
ToppCellCOVID-19_Mild|World / Disease group, lineage and cell class

SP100 PNN CHD1 JMJD1C ZEB2 SRRM2

1.50e-0519711965c33454b10023decd2f5ccda9229b6512659711e
ToppCellbackground-Kupffer_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

MYO5A LCP2 ZEB2 CD74 MERTK PIK3R5

1.50e-0519711968b45c7ecc18d188abc8c172d9bf881c95617a46a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DISC1 LCP2 SPECC1 ZEB2 CD74 PIK3R5

1.50e-051971196826cc6baafab13e7ef5cfcf28cd79d0fbf3af38d
ToppCellHealthy/Control-cDC|Healthy/Control / Disease group and Cell class

C1orf54 CDS1 CYP2E1 SPECC1 ZNF469 CD74

1.50e-051971196926423aae9fcf654f84b0f7621103a6a22d3aced
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THEMIS DISC1 LCP2 ZEB2 RASAL3 PIK3R5

1.50e-05197119661ef3f417767c3f5296a26399da63e3e4f58faf8
ToppCellBL-critical-LOC-Epithelial|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ST6GALNAC1 BICDL2 ARHGAP32 CDS1 SELENBP1 DNAI4

1.55e-0519811966218a25b94d5fa2c69880539adf9c63bfe52dcd3
ToppCellCOVID-19-Myeloid|COVID-19 / group, cell type (main and fine annotations)

MYO5A LCP2 ZEB2 CD74 MERTK PIK3R5

1.55e-05198119633f0a919188a67d2a876b52c61a1cec2c9747969
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

OGFR NT5C3B LCP2 ZEB2 MERTK PIK3R5

1.55e-0519811962b724d2a36843801984d46a969d33149b76c9771
ToppCellImmune|World / Lineage, Cell type, age group and donor

MYO5A LCP2 CBL ZEB2 CD74 PIK3R5

1.55e-05198119665681b54d13c6997bd90a1c2a12314a80e964fe3
ToppCellCOVID-19_Mild|World / Disease condition and Cell class

FLNA SP100 CHD1 LCP2 ZEB2 SRRM2

1.55e-05198119661ceb2245b6cb58e308b999a61d218c89dbc615e
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)

SP100 PNN CHD1 JMJD1C ZEB2 SRRM2

1.55e-05198119644417089b62056269cac38d3134ff209c05b7007
ToppCellTracheal-NucSeq-Immune_Myeloid-Mast_cell-Mast_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TNIK LCP2 SPECC1 ZEB2 BTK KIT

1.55e-051981196cc5ca64749e2f4f1d373d9472824df85741702b7
ToppCellTracheal-NucSeq-Immune_Myeloid-Mast_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TNIK LCP2 SPECC1 ZEB2 BTK KIT

1.55e-051981196d4d66f19df078bfc3a83d4664aaf9c7789bde1a5
ToppCellAdult-Immune|Adult / Lineage, Cell type, age group and donor

MYO5A DISC1 LCP2 ZEB2 VCAN PIK3R5

1.55e-0519811969bfd7b88aa646eaf5eddb15cf985c7ca910cb35e
ToppCellTracheal-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD16|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DISC1 LCP2 ZEB2 CD74 MERTK PIK3R5

1.55e-0519811960b928a829844f49f4d47e88908af192cb919011f
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CHIT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYO5A DISC1 ZEB2 BTK MERTK PIK3R5

1.55e-0519811960b41b3d6c2db795320e8b65d40d85fb8b618cc34
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SP100 PNN CHD1 JMJD1C ZEB2 SRRM2

1.55e-05198119628ef3fc4c17dcb765537b75917f7db78baa522db
ToppCellImmune-monocyte|World / Lineage, Cell type, age group and donor

DISC1 LCP2 SPECC1 ZEB2 VCAN PIK3R5

1.55e-051981196d3622da252fd580f1dc5c7478a8e23df5ec083cf
ToppCellCTRL-Myeloid|CTRL / Disease state, Lineage and Cell class

FLNA TRIO MYO5A ZEB2 CD74 PIK3R5

1.59e-05199119670b89a930709fdb91fde6f96106add8455b11618
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

THEMIS LCP2 ZEB2 RASAL3 SETBP1 PIK3R5

1.59e-0519911967d69785717073491b5fb81bf24db0175f86cd0b0
ToppCellParenchymal-NucSeq-Immune_Myeloid|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYO5A DISC1 LCP2 ZEB2 BTK PIK3R5

1.59e-0519911967ee2805fd9143eba11bf6832267b62189683608b
ToppCellcellseq-Immune-Immune_Myeloid-IM|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MYO5A LCP2 ZEB2 CD74 MERTK PIK3R5

1.59e-051991196b3267d5a7ae0461f5e9e6a3ab6783317a8c42506
DrugDipyrone [5907-38-0]; Down 200; 12uM; MCF7; HT_HG-U133A

TRIO RRP1B MAST2 CBL SNX13 CEP350 NF1 KDM8 SYMPK

8.25e-0719511893835_DN
DrugThimerosal

MYO5A BAG4 KAT6A LRRC37A2 BCOR CBL SPECC1 JMJD1C CEP350 TBC1D16 FSIP2 INTS6 NF1 VSIG10L KMT2A LRRC7 SRRM2 SPEN USP1 ADGRL3

3.39e-06119911820ctd:D013849
DrugPrimaquine diphosphate [63-45-6]; Down 200; 8.8uM; MCF7; HT_HG-U133A

ARHGAP32 PMS2 TRIO ARFGEF1 MADD CEP350 KMT2A SPEN

6.28e-0618811884845_DN
DrugMethapyrilene hydrochloride [135-23-9]; Down 200; 13.4uM; PC3; HT_HG-U133A

TRIO OGFR KAT6A KIAA0753 CEP350 NF1 VCAN KMT2A

7.05e-0619111886644_DN
Drug1-hydroxymethylpyrene

CYP2E1 SULT1B1 SULT1A1

7.46e-0681183ctd:C065833
DrugOrlistat; Up 200; 10uM; MCF7; HT_HG-U133A

TRIO DISC1 SULT1B1 NF1 VCAN SETBP1 CD74 CYP4F11

8.21e-0619511886415_UP
DrugMeclofenoxate hydrochloride [3685-84-5]; Down 200; 13.6uM; MCF7; HT_HG-U133A

USP36 MAST2 CBL NCOR2 NF1 KMT2A CYP4F11 SYMPK

9.18e-0619811884729_DN
DrugAdrenosterone [382-45-6]; Up 200; 13.4uM; MCF7; HT_HG-U133A

LUZP4 C1orf54 OGFR DISC1 KIAA0753 VCAN SETBP1 PIK3R5

9.18e-0619811885464_UP
DrugMeropenem [96036-03-2]; Down 200; 10.4uM; PC3; HT_HG-U133A

RRP1B DISC1 RBKS MAST2 MADD CEP350 EGF ASCC2

9.52e-0619911885824_DN
DrugPridinol methanesulfonate salt [6856-31-1]; Down 200; 10.2uM; HL60; HT_HG-U133A

SP100 CDS1 CYP2E1 OGFR SULT1B1 SH3PXD2A KDM8 ADGRL3

9.52e-0619911882715_DN
Druggeldanamycin

USP36 MYO5A KAT6A BCOR CBL JMJD1C NF1 EGF KMT2A SRRM2

2.39e-0537111810ctd:C001277
Druganti-BaPDE

FLNA SELENBP1 CYP2E1 TOPBP1 VPS54 FASLG VCAN CYP4F11

3.06e-052341188CID000041322
DrugNSC226080

SELENBP1 MID2 MYO5A CBL FASLG INTS6 NF1 EGF VCAN PAK2 COBL ULK1 KIT PIK3R5

5.43e-0578211814CID000005040
DrugKetanserin tartrate hydrate [83846-83-7]; Down 200; 7uM; PC3; HT_HG-U133A

TRIO KAT6A CEP350 NF1 VCAN KMT2A SRRM2

5.90e-0518911876649_DN
DrugResveratrol [501-36-0]; Down 200; 17.6uM; PC3; HT_HG-U133A

SP100 TRIO OGFR MAST2 NF1 EGF VCAN

5.90e-0518911875084_DN
Drugglycidamide

EME1 PMS2 SELENBP1 CYP2E1 SULT1A1 CYP4F11

6.03e-051301186ctd:C071834
DrugChelidonine monohydrate (+) [476-32-4]; Up 200; 10.8uM; MCF7; HT_HG-U133A

FLNA TRIO OGFR KAT6A CEP350 NF1 CD74

6.30e-0519111876236_UP
DrugHomatropine hydrobromide (R,S) [51-56-9]; Down 200; 11.2uM; PC3; HT_HG-U133A

SP100 OGFR KAT6A CBL SNX13 CEP350 KMT2A

6.51e-0519211875058_DN
DrugLY-171,883; Down 200; 1uM; MCF7; HG-U133A

C1orf54 SP100 DISC1 NF1 SETBP1 COBL ADGRL3

6.95e-051941187222_DN
DrugCarbamazepine [298-46-4]; Down 200; 17uM; PC3; HT_HG-U133A

TNIK SP100 RRP1B KAT6A CBL SULT1B1 NF1

7.18e-0519511875093_DN
Drugestradiol, USP; Down 200; 0.01uM; HL60; HT_HG-U133A

PMS2 RRP1B ARFGEF1 RBKS NF1 VCAN SYMPK

7.41e-0519611871182_DN
DrugEstropipate [7280-37-7]; Down 200; 9.2uM; HL60; HT_HG-U133A

C1orf54 BAG4 ARFGEF1 RBKS KIAA0753 NF1 ULK1

7.41e-0519611872506_DN
DrugFlurbiprofen [5104-49-4]; Down 200; 16.4uM; HL60; HT_HG-U133A

BEND5 CBL SNX13 NF1 ARHGAP44 KMT2A ADGRL3

7.41e-0519611873095_DN
DrugJosamycin [16846-24-5]; Down 200; 4.8uM; PC3; HT_HG-U133A

SP100 SLC29A3 CYP2E1 OGFR NF1 ADGRL3 SYMPK

7.65e-0519711874631_DN
DrugCinchonine [118-10-5]; Down 200; 13.6uM; HL60; HT_HG-U133A

OGFR KAT6A SNX13 SULT1B1 VCAN SRRM2 SYMPK

7.65e-0519711872133_DN
Drug0198306-0000 [212631-61-3]; Up 200; 10uM; PC3; HT_HG-U133A

CDS1 SLC29A3 CYP2E1 OGFR MAST2 VCAN SYMPK

7.65e-0519711877069_UP
DrugMetoclopramide monohydrochloride [7232-21-5]; Up 200; 11.8uM; HL60; HT_HG-U133A

SP100 OGFR KAT6A CEP350 NF1 SRRM2 SPEN

7.65e-0519711872353_UP
DrugFlucloxacillin sodium [1847-24-1]; Up 200; 8.4uM; PC3; HT_HG-U133A

CYP2E1 OGFR NF1 VCAN KMT2A COBL PIK3R5

7.90e-0519811875102_UP
Drug(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Down 200; 11.8uM; MCF7; HT_HG-U133A

SP100 OGFR KAT6A MAST2 CBL SULT1B1 DNAI4

7.90e-0519811876053_DN
DrugTroleandomycin [2751-09-9]; Up 200; 5uM; HL60; HG-U133A

MID2 TRIO RBKS BCOR MAST2 CBL SULT1B1

7.90e-0519811871965_UP
DrugMephenesin [59-47-2]; Down 200; 22uM; MCF7; HT_HG-U133A

OGFR BAG4 NCOR2 NF1 KDM8 MERTK CYP4F11

7.90e-0519811874698_DN
Drug1-methylpyrene

CYP2E1 SULT1A1

7.96e-0531182ctd:C053035
Drug5-hydroxy-3-methylindole

CYP2E1 SULT1A1

7.96e-0531182CID000192734
DrugIopamidol [60166-93-0]; Down 200; 5.2uM; PC3; HT_HG-U133A

SP100 TRIO OGFR BAG4 CEP350 COBL ULK1

8.15e-0519911875832_DN
DrugTetracycline hydrochloride [64-75-5]; Down 200; 8.4uM; MCF7; HT_HG-U133A

C1orf54 CYP2E1 DISC1 MAST2 NF1 KMT2A KDM8

8.15e-0519911872243_DN
DrugNitrofurantoin [67-20-9]; Up 200; 16.8uM; HL60; HT_HG-U133A

USP36 SLC29A3 MAST2 KIAA0753 NF1 DNAI4 ULK1

8.15e-0519911872341_UP
DrugEKB-569

TNIK GAK EGF BTK KIT

9.04e-05871185CID006445562
DiseaseMalignant neoplasm of breast

FLNA CDS1 APC2 LRRC37A2 ZEB2 NF1 LRRC37A EGF SULT1A1 BTK SETBP1 NHS CD74 LRRC7 SPEN KIT MRPL9

1.19e-06107411717C0006142
DiseaseBreast Carcinoma

FLNA APC2 LRRC37A2 ZEB2 LRRC37A EGF SULT1A1 BTK SETBP1 CD74 KIT MRPL9

1.61e-0653811712C0678222
DiseaseLeukemia, Myelocytic, Acute

TRIO BCOR CBL NF1 SETBP1 KMT2A KIT

6.08e-061731177C0023467
DiseaseMammary Carcinoma, Human

FLNA APC2 LRRC37A2 ZEB2 LRRC37A EGF SULT1A1 SETBP1 CD74 KIT MRPL9

8.10e-0652511711C4704874
DiseaseMammary Neoplasms, Human

FLNA APC2 LRRC37A2 ZEB2 LRRC37A EGF SULT1A1 SETBP1 CD74 KIT MRPL9

8.10e-0652511711C1257931
DiseaseMammary Neoplasms

FLNA APC2 LRRC37A2 ZEB2 LRRC37A EGF SULT1A1 SETBP1 CD74 KIT MRPL9

8.39e-0652711711C1458155
Diseaseacute myeloid leukemia (is_implicated_in)

KAT6A CBL NF1 KMT2A KIT

2.16e-05841175DOID:9119 (is_implicated_in)
DiseaseJuvenile Myelomonocytic Leukemia

CBL NF1 SETBP1

5.62e-05191173C0349639
DiseaseJUVENILE MYELOMONOCYTIC LEUKEMIA

CBL NF1

9.30e-0541172607785
DiseaseMalignant Peripheral Nerve Sheath Tumor

NF1 SH3PXD2A

9.30e-0541172C0751690
DiseaseJuvenile myelomonocytic leukemia

CBL NF1

9.30e-0541172cv:C0349639
DiseaseAcute myelomonocytic leukemia

KMT2A KIT

1.55e-0451172C0023479
DiseaseMyelomonocytic leukemia

CBL SETBP1

1.55e-0451172C0027019
Diseasewhite matter microstructure measurement

TNIK DISC1 MAST2 AXDND1 SH3PXD2A VCAN SETBP1 PAK2

1.69e-043901178EFO_0005674
Diseasereticulocyte measurement

FLNA COPB1 CBL SPECC1 JMJD1C ZEB2 SNX13 NUFIP1 ZNF469 EGF SETBP1 ASCC2 PAK2

2.84e-04105311713EFO_0010700
Diseaseliver disease (biomarker_via_orthology)

CYP2E1 FASLG

3.23e-0471172DOID:409 (biomarker_via_orthology)
Diseasejuvenile myelomonocytic leukemia (is_implicated_in)

CBL NF1

3.23e-0471172DOID:0050458 (is_implicated_in)
DiseaseColorectal Carcinoma

UNC13B PMS2 SELENBP1 APC2 ARFGEF1 CHD1 ZEB2 NF1 SETBP1 PIK3R5

4.95e-0470211710C0009402
Diseasehigh grade glioma (is_implicated_in)

CYP2E1 NF1 EGF

6.23e-04421173DOID:3070 (is_implicated_in)
DiseaseAdenoid Cystic Carcinoma

KAT6A BCOR JMJD1C VCAN

6.87e-041001174C0010606
DiseaseProstatic Neoplasms

CYP2E1 KAT6A CHD1 FASLG SSX2 EGF SULT1A1 KMT2A SPEN

7.96e-046161179C0033578
DiseaseMalignant neoplasm of prostate

CYP2E1 KAT6A CHD1 FASLG SSX2 EGF SULT1A1 KMT2A SPEN

7.96e-046161179C0376358
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

NCOR2 RASAL3 TANC1

9.80e-04491173DOID:0060037 (implicated_via_orthology)
Diseaseairway wall thickness measurement

NT5C3B C10orf90

1.00e-03121172EFO_0006898
Diseasehemoglobin A1 measurement

MAST2 SPECC1 JMJD1C MADD EGF ASCC2 PAK2 YTHDF2

1.12e-035201178EFO_0007629
DiseaseCarcinoma, Granular Cell

SELENBP1 CYP2E1 EGF KMT2A

1.19e-031161174C0205644
DiseaseAdenocarcinoma, Tubular

SELENBP1 CYP2E1 EGF KMT2A

1.19e-031161174C0205645
DiseaseAdenocarcinoma, Oxyphilic

SELENBP1 CYP2E1 EGF KMT2A

1.19e-031161174C0205642
DiseaseCarcinoma, Cribriform

SELENBP1 CYP2E1 EGF KMT2A

1.19e-031161174C0205643
DiseaseAdenocarcinoma, Basal Cell

SELENBP1 CYP2E1 EGF KMT2A

1.19e-031161174C0205641
DiseaseAdenocarcinoma

SELENBP1 CYP2E1 EGF KMT2A

1.19e-031161174C0001418
Diseasewhite matter hyperintensity measurement

C1orf54 NCOR2 SULT1B1 SH3PXD2A VCAN SETBP1

1.32e-033021176EFO_0005665
DiseaseAcute Myeloid Leukemia, M1

TRIO NF1 KMT2A KIT

1.57e-031251174C0026998
DiseaseAcute Myeloid Leukemia (AML-M2)

TRIO NF1 KMT2A KIT

1.57e-031251174C1879321
DiseaseRASopathy

CBL NF1

1.58e-03151172cv:C5555857
Diseaseteratocarcinoma-derived growth factor 1 measurement

MYO5A KMT2A

1.80e-03161172EFO_0008297
DiseaseChromosome Aberrations

SULT1A1 KMT2A

1.80e-03161172C0008625
DiseaseAutosome Abnormalities

SULT1A1 KMT2A

1.80e-03161172C0004403
Diseaseautosomal dominant intellectual developmental disorder (is_implicated_in)

TRIO SRRM2

2.04e-03171172DOID:0060307 (is_implicated_in)
DiseaseMyeloid Leukemia

SETBP1 KMT2A

2.29e-03181172C0023470
DiseaseLeukemia, Monocytic, Chronic

SETBP1 KMT2A

2.29e-03181172C0023466
DiseaseProfound Mental Retardation

DISC1 NF1 SETBP1 CACNA1G

2.32e-031391174C0020796
DiseaseMental Retardation, Psychosocial

DISC1 NF1 SETBP1 CACNA1G

2.32e-031391174C0025363
DiseaseMental deficiency

DISC1 NF1 SETBP1 CACNA1G

2.32e-031391174C0917816
DiseaseParkinson's disease (is_marker_for)

FASLG EGF SRRM2

2.42e-03671173DOID:14330 (is_marker_for)
DiseaseSchizophrenia

ST6GALNAC1 TNIK ARHGAP32 SELENBP1 CYP2E1 DISC1 SH3PXD2A PI4KA PAK2 KMT2A

2.74e-0388311710C0036341
Diseasestomach cancer (is_implicated_in)

CYP2E1 BCOR SULT1A1

2.97e-03721173DOID:10534 (is_implicated_in)
Diseasereticulocyte count

COPB1 CD2AP MAST2 CBL SPECC1 JMJD1C NUFIP1 ZNF469 EGF SETBP1 ASCC2

2.97e-03104511711EFO_0007986
DiseaseAnophthalmia-microphthalmia syndrome

BCOR NHS

3.12e-03211172cv:C5680330
Diseaseserum non-albumin protein measurement

SP100 KAT6A MAST2 TBC1D16 NCOR2 EGF

3.23e-033611176EFO_0004568
Diseaseglucagon measurement

TNIK C10orf90 ZNF469 KDM8

3.35e-031541174EFO_0008463
Diseaseurinary bladder cancer (is_implicated_in)

PMS2 FASLG SULT1A1

3.46e-03761173DOID:11054 (is_implicated_in)
DiseaseNon-Small Cell Lung Carcinoma

CYP2E1 FASLG CD74 KIT

3.51e-031561174C0007131
DiseaseHereditary Paraganglioma-Pheochromocytoma Syndrome

NF1 MERTK

3.73e-03231172C1708353

Protein segments in the cluster

PeptideGeneStartEntry
LPKTITAEVHPVPLR

USH1C

386

Q9Y6N9
PKPPLSPHKLSIVRE

BEND5

356

Q7L4P6
PSDESTPPSIKKIIH

BAG4

371

O95429
PIEIDPHRTVKEKLP

NT5C3B

86

Q969T7
IPPSSDRTPEILKKA

CDS1

61

Q92903
KHIPSKEFPVTETPL

VCAN

506

P13611
SSAITKKPPLIDREP

VCAN

1226

P13611
HRKTKKPLPPTPEED

BTK

181

Q06187
GPPDPKSHELRSKIL

ARFGEF1

441

Q9Y6D6
PKTGKLRTSPALHPE

ASCC2

16

Q9H1I8
PPIHLDSELERPSVK

ADGRL3

411

Q9HAR2
ETLKPDPHLRKSPSL

SPECC1

901

Q5M775
PTHSPEKILKLPKEE

CD2AP

511

Q9Y5K6
KKHHIPVVDRTPLEP

BMS1

66

Q14692
PHTPIEITKEEKPER

BCOR

731

Q6W2J9
EKKLLFISEPIPHPS

DBF4

406

Q9UBU7
LIPLHKSIPSDPEER

CHD1

1221

O14646
PIPPRLHSEDKRKTP

DISC1

731

Q9NRI5
EKEPSGTRLPPKTHR

ATXN7L2

216

Q5T6C5
APRDLPKHTPLISKS

RASAL3

771

Q86YV0
KSPHFREKSPVREPV

RBM23

141

Q86U06
KPLVDPKDIDLSPIH

CYP2E1

461

P05181
PDLIKPLPLHKISET

INTS6

691

Q9UL03
KLTLSEKVPPNHPSR

LUZP4

6

Q9P127
QTEPEPKHIPTEKVK

RBKS

246

Q9H477
EPLLVVKPTHSRPEG

FAM90A23

221

A8MXZ1
ETGVSHLRPEPPKIL

FAM47C

516

Q5HY64
EKPVSPPPIESKHRS

NCOR2

211

Q9Y618
PKRTIVSPKHPEVTL

LRRC37A3

631

O60309
SVIKHSPTVKREPPS

MADD

916

Q8WXG6
SELEPFHPKPKIRTR

MDC1

1096

Q14676
PKRTIVSPKHPEVTL

LRRC37A2

631

A6NM11
PKRTIVSPKHPEVTL

LRRC37A

631

A6NMS7
PPSIHPGKSDLIVRV

KIT

36

P10721
VESKPLPPLAFKHTV

MERTK

86

Q12866
PTTSPLPERKEHIKE

LRRC7

866

Q96NW7
DKLHKRSPPPETIKS

JMJD1C

611

Q15652
PDVKLEKTVPRLHRP

KDM8

176

Q8N371
EVKLKEPHISPIAPI

FSIP2

1766

Q5CZC0
TDVPLPKPSHADKLS

FSIP2

6161

Q5CZC0
EPLLVVKPTHSRPEG

FAM90A14

221

P0C7W9
PVEPVLTVHPESKSK

PNN

541

Q9H307
LKLVEKPSPLTLAPH

COPB1

766

P53618
EESLLSKLFPKIPPH

PI4KA

201

P42356
EPLLVVKPTHSRPEG

FAM90A17

221

P0DV74
SIVPPPKPERSHSLK

ARHGAP32

1976

A7KAX9
EPLLVVKPTHSRPEG

FAM90A16

221

P0DV73
EPLLVVKPTHSRPEG

FAM90A8

221

A6NJQ4
VSLLPHEKDKPVAEP

KAT6A

191

Q92794
PSVPEEKKPRHKIIS

PAK2

41

Q13177
EPITPHSKPILVRAV

GAK

566

O14976
EAATKKPLPPLRHLD

APC2

751

O95996
PTVHTSPPPETLKEK

CACNA1G

591

O43497
LKPSSLVVVHPLAKP

EGF

726

P01133
PRSPFKVKVLPTHDA

FLNA

1531

P21333
IVPHKPKTLTDTLIP

AXDND1

161

Q5T1B0
ILPTHTEPRRKPELI

CYP4F11

491

Q9HBI6
VPPRPHSEPSRKIKE

C4orf17

106

Q53FE4
KPVVQRPVPKDTSLH

COBL

1096

O75128
KPKIKPLTPLHRSET

CEP350

2131

Q5VT06
IAKPTVDTKPPVAHT

CFAP97D1

41

B2RV13
LEPPKKRTSLSPAEI

BICDL2

341

A1A5D9
DLPHSELKKELPPRE

MAST2

1431

Q6P0Q8
HPDPLTGTAKPSKLL

DNAI4

131

Q5VTH9
TTPPHLKPATEKLIV

KMT2A

3066

Q03164
PHRVKTEPPVKLEKH

BRMS1L

236

Q5PSV4
SLHKDKPLPVPPTLR

CBL

526

P22681
KIPEVPLHDTPERSA

EME1

141

Q96AY2
HSLEQKPTDAPPKVL

CD74

196

P04233
LDSPRKIIPSPGKEH

CCDC158

61

Q5M9N0
EPLLVVKPTHSRPEG

FAM90A5P

221

A8MXJ8
RPLSPILHIVKDESP

SEC24B

1221

O95487
EPLLVVKPTHSRPEG

FAM90A24P

221

P0C7X0
PPELPKSTEIHEQKR

MUCL3

71

Q3MIW9
KPSSLPHPLEGSRKV

OGFR

296

Q9NZT2
PEPTEIPALKQSKDH

GTF2E1

206

P29083
IDSHTPPLRPILKKT

SLC29A3

291

Q9BZD2
PLIPKTDSDPEHRRV

SNX13

756

Q9Y5W8
LHRLVTKPPKTTNPS

SLITRK4

296

Q8IW52
DPEQKPLHGVLKTPT

RRP1B

716

Q14684
DTKVKPETPPRQSHS

SRRM2

976

Q9UQ35
SKDLELPIIPPTHLD

NHS

1076

Q6T4R5
EPLLVVKPTHSRPEG

FAM90A12P

221

A8MX19
EPLLVVKPTHSRPEG

FAM90A13P

221

P0C7W8
LPSFIKEPQTKPSRH

ST6GALNAC1

31

Q9NSC7
PAHPLPSKTKTTERL

TANC1

1616

Q9C0D5
SEPRAPKLHKVIEPK

SELENBP1

111

Q13228
KISAISEKPLSPHPI

KIAA0753

816

Q2KHM9
SEKPLSPHPIRITKT

KIAA0753

821

Q2KHM9
PHTLRKVSKKLAPIP

ARHGAP44

641

Q17R89
EPLLVVKPTHSRPEG

FAM90A15P

221

P0C7V4
PSPRIVKTHLPTDLL

SULT1B1

101

O43704
ETARADHPKPVTVKP

C1orf54

81

Q8WWF1
LPIRTSKKQFTIPHP

C10orf90

616

Q96M02
VAPHTLKLPEEPITR

MRPL9

201

Q9BYD2
RPPKHPSVEETKLTL

THEMIS

556

Q8N1K5
VLPHEPAKVKPEESR

TNIK

771

Q9UKE5
HVRFPSESLKVPSKP

WDR90

221

Q96KV7
HSPKKELPAEEPSVL

ZSCAN10

106

Q96SZ4
RPSLEKPEPIHLSVS

SPEN

2906

Q96T58
EKPQHSVIPKEVTPA

NUFIP1

346

Q9UHK0
PPGKPTTSEKIHERS

SSX2

141

Q16385
DTAKPGKLHTIPIPV

PIK3R5

271

Q8WYR1
SPVRPKPIEKSQFIH

SH3PXD2A

1056

Q5TCZ1
LKDTPAPRLLKTHLP

SULT1A1

96

P50225
ELLHSSSLVKPPAPK

THAP5

141

Q7Z6K1
PEPPSTRKKRILESH

SP100

676

P23497
IRRPKLPSSETHPEE

TBC1D16

376

Q8TBP0
PDSIPQHTKIRPKDV

NF1

1836

P21359
VLPRDKDTPLSHIEP

SERPINE3

261

A8MV23
PESTPELPVKHLRAA

SEMA6C

701

Q9H3T2
PTPHKILLDTRFELP

UNC13B

116

O14795
RIPVSKSQPVTPEKH

TERF1

361

P54274
HSLTDKVPPSPELVK

SYMPK

861

Q92797
PPPEKKELRKVAHLT

FASLG

136

P48023
ENKPHSPKTPEPRRS

PMS2

431

P54278
SLHKSLTKILPERPP

ZNF469

371

Q96JG9
EKKKHPSTLVPVVTP

VSIG10L

811

Q86VR7
PNKKPFTSHRLVEPV

MID2

171

Q9UJV3
PPLRLTKPSHFTNIK

ZEB2

756

O60315
EPKTAIKHPRPVSSQ

SETBP1

741

Q9Y6X0
PLQKEPSLHLDTPSK

TOPBP1

811

Q92547
PKHPISEELETPIKD

TOPBP1

1211

Q92547
SDLHVVRPKLPKPPT

ULK1

561

O75385
HLGKVSKPVSPSLDP

TSHZ1

756

Q6ZSZ6
SLPGRPSVIPDHSKK

USP36

441

Q9P275
VAELPTKVEEIPHPK

USP1

226

O94782
TPSEPHPVLEKLRSI

YTHDF2

381

Q9Y5A9
LKEPIHIPKTAPATR

TRIO

1601

O75962
KIEVDPSKHIRPVPS

VPS54

21

Q9P1Q0
TERHERSSPLPGKKP

LCP2

291

Q13094
IPSRTEEPSEKKVPL

MYO5A

1136

Q9Y4I1
TEPRPEEPPKEKLHT

MYO7B

1596

Q6PIF6