Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	molecular adaptor activity	SPTBN4 DLG5 DDX17 PAGE4 SH2B3 WTIP BAZ2A LIAT1 SUN2 EIF4G1 DVL2 NSD1 FGF2 FBXL19 HCN2 ZXDA NOTCH1 DDX5 ZXDB	3.87e-06	1356	86	19	GO:0060090
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	SPTBN4 DLG5 DDX17 PAGE4 SH2B3 WTIP BAZ2A LIAT1 SUN2 DVL2 NSD1 FGF2 FBXL19 ZXDA NOTCH1 DDX5 ZXDB	7.65e-06	1160	86	17	GO:0030674
GeneOntologyMolecularFunction	transcription coregulator activity	DDX17 PAGE4 WTIP NSD1 FGF2 FBXL19 ZXDA NOTCH1 DDX5 ZXDB	1.50e-04	562	86	10	GO:0003712
GeneOntologyMolecularFunction	nuclear localization sequence binding	CABP1 POM121 POM121C	2.09e-04	27	86	3	GO:0008139
GeneOntologyMolecularFunction	dolichyl-phosphate-mannose-protein mannosyltransferase activity	POMT2 TMTC1	5.05e-04	8	86	2	GO:0004169
HumanPheno	Aortic arch aneurysm	EIF4H CHD7 GTF2IRD1 NOTCH1 SMAD6	2.25e-06	41	28	5	HP:0005113
HumanPheno	Compulsive behaviors	EIF4H IQSEC2 AUTS2 PIDD1 CHD7 DMPK GTF2IRD1	1.65e-05	158	28	7	HP:0000722
HumanPheno	Auditory sensitivity	EIF4H IQSEC2 AUTS2 GTF2IRD1	4.26e-05	37	28	4	HP:0025112
HumanPheno	Pulmonic stenosis	EIF4H NEK8 CHD7 GTF2IRD1 NOTCH1 SMAD6	8.17e-05	138	28	6	HP:0001642
Domain	BAT2_N	PRRC2A PRRC2B	5.98e-05	3	84	2	PF07001
Domain	BAT2_N	PRRC2A PRRC2B	5.98e-05	3	84	2	IPR009738
Domain	PRRC2	PRRC2A PRRC2B	5.98e-05	3	84	2	IPR033184
Domain	PH	SPTBN4 SH2B3 ARHGAP23 IQSEC2 DOK3 OSBPL10 ARHGEF25	2.56e-04	278	84	7	SM00233
Domain	PH_DOMAIN	SPTBN4 SH2B3 ARHGAP23 IQSEC2 DOK3 OSBPL10 ARHGEF25	2.61e-04	279	84	7	PS50003
Domain	PH_domain	SPTBN4 SH2B3 ARHGAP23 IQSEC2 DOK3 OSBPL10 ARHGEF25	2.67e-04	280	84	7	IPR001849
Domain	-	SPTBN4 SH2B3 ARHGAP23 NUMBL IQSEC2 DOK3 OSBPL10 ARHGEF25	3.74e-04	391	84	8	2.30.29.30
Domain	PDZ	DLG5 ARHGAP23 DVL2 PRX MAST3	4.37e-04	141	84	5	PF00595
Domain	PDZ	DLG5 ARHGAP23 DVL2 PRX MAST3	5.45e-04	148	84	5	SM00228
Domain	-	DLG5 ARHGAP23 DVL2 PRX MAST3	5.79e-04	150	84	5	2.30.42.10
Domain	PDZ	DLG5 ARHGAP23 DVL2 PRX MAST3	5.97e-04	151	84	5	PS50106
Domain	PDZ	DLG5 ARHGAP23 DVL2 PRX MAST3	6.15e-04	152	84	5	IPR001478
Domain	PH_dom-like	SPTBN4 SH2B3 ARHGAP23 NUMBL IQSEC2 DOK3 OSBPL10 ARHGEF25	6.58e-04	426	84	8	IPR011993
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SPTBN4 SART1 ZNF219 LZTS3 NUMBL WTIP IQSEC2 EIF4G1 DVL2 NSD1 FBXO41 CHD7 EML1 HCN2 PRRC2A PRRC2B	2.81e-09	963	89	16	28671696
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	SPTBN4 SART1 ZNF609 ZNF219 DDX17 MEGF8 EIF4H WTIP SUN2 FGF2 FBXL19 DMPK SNRNP70 TERF2 CCDC61 SMAD6	6.43e-09	1021	89	16	26760575
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FAM193B ORAI1 EPPK1 MEGF8 SH2B3 NEK8 EIF4G1 NSD1 TNRC6C FBXL19 GTF2IRD1 POM121C NOTCH1 PRRC2B	8.18e-07	1105	89	14	35748872
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SART1 ZNF609 ZNF219 DDX17 BAZ2A WDR33 SUN2 POP1 NSD1 CHD7 SNRNP70 GTF2IRD1 POM121C TERF2 DDX5	9.64e-07	1294	89	15	30804502
Pubmed	Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s).	POM121 EIF4H GTF2IRD1 POM121C	1.97e-06	35	89	4	11013070
Pubmed	Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.	POM121 EIF4H GTF2IRD1 POM121C	2.77e-06	38	89	4	11779826
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	FAM193B ZNF609 POM121 MEGF8 NUMBL DVL2 DMPK PRRC2A NOTCH1 PRRC2B	3.65e-06	608	89	10	16713569
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SART1 DLG5 DDX17 NUMBL WDR33 SUN2 KHDRBS2 EIF4G1 CHD7 SNRNP70 GTF2IRD1 CCDC61 DDX5	3.75e-06	1082	89	13	38697112
Pubmed	Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.	SART1 WDR33 EIF4G1 PRRC2A	4.58e-06	43	89	4	34672947
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	DDX17 EIF4H EIF4G1 SNRNP70 PRRC2A DDX5 PRRC2B	4.68e-06	258	89	7	37794589
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FAM193B POM121 TBC1D30 ARHGAP23 SUN2 POP1 POM121C PRX MAST3	5.00e-06	493	89	9	15368895
Pubmed	The Ddx5 and Ddx17 RNA helicases are cornerstones in the complex regulatory array of steroid hormone-signaling pathways.	DDX17 DDX5	6.48e-06	2	89	2	24275493
Pubmed	C2CD4A/B variants in the predisposition of lung cancer in the Chinese Han population.	C2CD4B C2CD4A	6.48e-06	2	89	2	35212842
Pubmed	Helicases DDX5 and DDX17 promote heterogeneity in HBV transcription termination in infected human hepatocytes.	DDX17 DDX5	6.48e-06	2	89	2	38782119
Pubmed	Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.	C2CD4B C2CD4A	6.48e-06	2	89	2	33492421
Pubmed	Involvement of RNA helicases p68 and p72 in colon cancer.	DDX17 DDX5	6.48e-06	2	89	2	17699760
Pubmed	Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies.	ZXDA ZXDB	6.48e-06	2	89	2	8268913
Pubmed	A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression.	C2CD4B C2CD4A	6.48e-06	2	89	2	29625024
Pubmed	Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis.	DDX17 DDX5	6.48e-06	2	89	2	18005418
Pubmed	The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells.	DDX17 DDX5	6.48e-06	2	89	2	12595555
Pubmed	Orai1 is critical for Notch-driven aggressiveness under hypoxic conditions in triple-negative breast cancers.	ORAI1 NOTCH1	6.48e-06	2	89	2	29307746
Pubmed	Upregulation of DEAD box helicase 5 and 17 are correlated with the progression and poor prognosis in gliomas.	DDX17 DDX5	6.48e-06	2	89	2	32008867
Pubmed	The roles of DEAD box helicases in the life cycle of HIV-1.	DDX17 DDX5	6.48e-06	2	89	2	26312911
Pubmed	DDX5 is a positive regulator of oncogenic NOTCH1 signaling in T cell acute lymphoblastic leukemia.	NOTCH1 DDX5	6.48e-06	2	89	2	23108395
Pubmed	RH70, a bidirectional RNA helicase, co-purifies with U1snRNP.	DDX17 SNRNP70	6.48e-06	2	89	2	12193588
Pubmed	Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics.	SART1 DDX17 SUN2 POP1 EIF4G1 SNRNP70 PRRC2A DDX5	6.66e-06	384	89	8	31059266
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	SART1 EPPK1 BAZ2A POP1 EIF4G1 NSD1 CHD7 SNRNP70 PRRC2A PRRC2B	6.82e-06	653	89	10	22586326
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	SART1 EPPK1 DDX17 MRPL15 EIF4H WDR33 C11orf68 SNRNP70 PRRC2A DDX5 PRRC2B	6.92e-06	807	89	11	22681889
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	SART1 ZNF609 DDX17 SUN2 POP1 SNRNP70 POM121C PRRC2A DDX5 PRRC2B	7.01e-06	655	89	10	35819319
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	DLG5 LZTS3 IQSEC2 PRRC2B MAST3	7.73e-06	105	89	5	9628581
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	ZNF609 EPPK1 POM121 TSPOAP1 CHD7 POM121C NOTCH1 PRX	1.51e-05	430	89	8	35044719
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	SART1 DLG5 ZNF609 DDX17 EIF4H WDR33 SUN2 POP1 EIF4G1 SNRNP70 TERF2 PRRC2A DDX5	1.70e-05	1247	89	13	27684187
Pubmed	Notch transcriptional target tmtc1 maintains vascular homeostasis.	TMTC1 NOTCH1	1.94e-05	3	89	2	39190102
Pubmed	A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.	C2CD4B C2CD4A	1.94e-05	3	89	2	20818381
Pubmed	A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese.	C2CD4B C2CD4A	1.94e-05	3	89	2	21799836
Pubmed	POM121 inhibits the macrophage inflammatory response by impacting NF-κB P65 nuclear accumulation.	POM121 POM121C	1.94e-05	3	89	2	30802453
Pubmed	Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice.	C2CD4B C2CD4A	1.94e-05	3	89	2	27329800
Pubmed	Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine.	POM121 POM121C	1.94e-05	3	89	2	35507432
Pubmed	Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness.	DDX17 DDX5	1.94e-05	3	89	2	23022728
Pubmed	Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation.	EIF4H EIF4G1	1.94e-05	3	89	2	19203580
Pubmed	Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl.	NUMBL NOTCH1	1.94e-05	3	89	2	27521217
Pubmed	The Notch regulator Numb links the Notch and TCR signaling pathways.	NUMBL NOTCH1	1.94e-05	3	89	2	15634911
Pubmed	RNA helicases DDX5 and DDX17 dynamically orchestrate transcription, miRNA, and splicing programs in cell differentiation.	DDX17 DDX5	1.94e-05	3	89	2	24910439
Pubmed	The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer.	DDX17 DDX5	1.94e-05	3	89	2	19718048
Pubmed	Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor.	DDX17 DDX5	1.94e-05	3	89	2	22266867
Pubmed	The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway.	WTIP DDX5	1.94e-05	3	89	2	33108271
Pubmed	Notch1 mediates visfatin-induced FGF-2 up-regulation and endothelial angiogenesis.	FGF2 NOTCH1	1.94e-05	3	89	2	20817637
Pubmed	The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner.	DDX17 DDX5	1.94e-05	3	89	2	15298701
Pubmed	A novel gene family induced by acute inflammation in endothelial cells.	C2CD4B C2CD4A	1.94e-05	3	89	2	15527968
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	ZNF609 POM121 WDR33 SUN2 AUTS2 POM121C DDX5 PRRC2B	2.33e-05	457	89	8	32344865
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	SART1 BAZ2A SUN2 POP1 FGF2 POM121C PRRC2A	2.39e-05	332	89	7	25693804
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	EPPK1 DDX17 EIF4G1 NSD1 FGF2 PRRC2A PRRC2B	2.39e-05	332	89	7	37433992
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	SART1 LRIG3 ZNF609 ZNF219 MCTP1 ARHGAP23 BAZ2A SUN2 DVL2 HRES1 POM121C PRRC2B	2.74e-05	1116	89	12	31753913
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	SART1 DDX17 WDR33 POP1 EIF4G1 SNRNP70 PRRC2A DDX5	2.80e-05	469	89	8	37314180
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	SART1 DDX17 WDR33 EIF4G1 DVL2 SNRNP70 PRRC2A DDX5 PRRC2B	2.88e-05	615	89	9	31048545
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	SART1 ZNF609 DDX17 BAZ2A WDR33 EIF4G1 NSD1 CHD7 SNRNP70 PRRC2A DDX5	3.25e-05	954	89	11	36373674
Pubmed	The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor.	DDX17 DDX5	3.87e-05	4	89	2	15660129
Pubmed	Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes.	POM121 POM121C	3.87e-05	4	89	2	17900573
Pubmed	Different downstream pathways for Notch signaling are required for gliogenic and chondrogenic specification of mouse mesencephalic neural crest cells.	FGF2 NOTCH1	3.87e-05	4	89	2	18299190
Pubmed	Rare deleterious variants of NOTCH1, GATA4, SMAD6, and ROBO4 are enriched in BAV with early onset complications but not in BAV with heritable thoracic aortic disease.	NOTCH1 SMAD6	3.87e-05	4	89	2	32748548
Pubmed	Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions.	DDX17 DDX5	3.87e-05	4	89	2	32463358
Pubmed	Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis.	NUMBL NOTCH1	3.87e-05	4	89	2	8755477
Pubmed	Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis.	NUMBL NOTCH1	3.87e-05	4	89	2	9169836
Pubmed	Stabilized beta-catenin functions through TCF/LEF proteins and the Notch/RBP-Jkappa complex to promote proliferation and suppress differentiation of neural precursor cells.	FGF2 NOTCH1	3.87e-05	4	89	2	18852283
Pubmed	Identification of cytoplasmic proteins interacting with unliganded estrogen receptor α and β in human breast cancer cells.	DDX17 DDX5	3.87e-05	4	89	2	25604459
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	ZNF609 WDR33 AUTS2 TNRC6C PRRC2B	4.61e-05	152	89	5	38360978
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	SART1 DDX17 WDR33 SNRNP70 DDX5	4.91e-05	154	89	5	16055720
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	DLG5 POM121 DVL2 POM121C DDX5 PRRC2B	6.07e-05	263	89	6	34702444
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	SART1 DDX17 MRPL15 SUN2 POP1 EIF4G1 SNRNP70 SLC30A3 PRRC2A	6.12e-05	678	89	9	30209976
Pubmed	Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU.	DDX17 DDX5	6.44e-05	5	89	2	18279852
Pubmed	Identification of RNA helicases in human immunodeficiency virus 1 (HIV-1) replication - a targeted small interfering RNA library screen using pseudotyped and WT HIV-1.	DDX17 DDX5	6.44e-05	5	89	2	25701821
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	SART1 EPPK1 WDR33 POP1 CHD7 TERF2 PRRC2A	7.05e-05	394	89	7	27248496
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	LRIG3 MEGF8 EIF4H TSPOAP1 BAZ2A TNRC6C PRRC2B	8.62e-05	407	89	7	12693553
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	SART1 DDX17 MRPL15 WDR33 POP1 EIF4G1 SNRNP70 PRRC2A DDX5	8.98e-05	713	89	9	29802200
Pubmed	Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases.	DDX17 EIF4G1 DDX5	9.15e-05	34	89	3	16611982
Pubmed	Distinct DDX DEAD-box RNA helicases cooperate to modulate the HIV-1 Rev function.	DDX17 DDX5	9.65e-05	6	89	2	23608157
Pubmed	The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation.	DDX17 DDX5	9.65e-05	6	89	2	17011493
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	ZNF609 WDR33 POM121C NOTCH1 DDX5	1.03e-04	180	89	5	35198878
Pubmed	WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ΔNp73 levels.	DDX17 DVL2 PRRC2A DDX5	1.16e-04	97	89	4	25071155
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	SART1 EPPK1 LZTS3 ARHGAP23 KCTD8 FBXO41 HCN2	1.21e-04	430	89	7	32581705
Pubmed	The enigma of the numb-Notch relationship during mammalian embryogenesis.	NUMBL NOTCH1	1.35e-04	7	89	2	16508312
Pubmed	Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling.	NUMBL NOTCH1	1.35e-04	7	89	2	25535389
Pubmed	Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization.	NUMBL NOTCH1	1.35e-04	7	89	2	15598981
Pubmed	Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential.	DDX17 DDX5	1.35e-04	7	89	2	19995069
Pubmed	Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.	POM121 LZTS3 EIF4G1 PRRC2A	1.35e-04	101	89	4	26949739
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	SART1 ZNF609 DDX17 POM121 NUMBL NEK8 IQSEC2 FBXL19 POM121C DDX5 PRRC2B MAST3	1.37e-04	1321	89	12	27173435
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	FAM193B DDX17 EIF4H NUMBL BAZ2A DVL2 POM121C PRRC2A DDX5 PRRC2B	1.39e-04	934	89	10	33916271
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	SART1 DDX17 POP1 EIF4G1 SNRNP70 PRRC2A DDX5	1.42e-04	441	89	7	31239290
Pubmed	Proteomic analysis of HIV-1 Gag interacting partners using proximity-dependent biotinylation.	SART1 DDX17 DDX5	1.73e-04	42	89	3	26362536
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	DDX17 EIF4G1 DVL2 DMPK PRRC2A	1.76e-04	202	89	5	24639526
Pubmed	Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors.	FGF2 NOTCH1	1.79e-04	8	89	2	15509736
Pubmed	A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing.	EIF4G1 TNRC6C	1.79e-04	8	89	2	24768540
Pubmed	Laminar flow downregulates Notch activity to promote lymphatic sprouting.	ORAI1 NOTCH1	1.79e-04	8	89	2	28263185
Pubmed	Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase.	DDX17 DDX5	1.79e-04	8	89	2	20663877
Pubmed	Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy.	EPPK1 DDX17 EIF4G1 DDX5	1.82e-04	109	89	4	29511296
Pubmed	Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.	SART1 DDX17 SNRNP70 DDX5	2.23e-04	115	89	4	17332742
Pubmed	The SMN interactome includes Myb-binding protein 1a.	DDX17 SNRNP70 DDX5	2.27e-04	46	89	3	19928837
Pubmed	Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer.	DDX17 DDX5	2.30e-04	9	89	2	24581491
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	DDX17 LZTS3 WDR33 DVL2 PRRC2A	2.61e-04	220	89	5	24550385
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	FAM193B ARHGAP23 SUN2 NSD1 PIDD1 FGF2 SNRNP70 NOTCH1 DDX5 PRRC2B SMAD6	2.73e-04	1215	89	11	15146197
Interaction	ATN1 interactions	ZNF609 MEGF8 DVL2 AUTS2 DMPK TERF2 PRRC2A PRRC2B	1.48e-06	187	87	8	int:ATN1
Interaction	FMR1 interactions	ZNF219 NUMBL WTIP IQSEC2 EIF4G1 DVL2 CHD7 EML1 SNRNP70 PRRC2A DDX5 PRRC2B	3.21e-06	536	87	12	int:FMR1
Interaction	MECP2 interactions	SART1 DLG5 DDX17 ARHGAP23 NUMBL WDR33 SUN2 POP1 KHDRBS2 EIF4G1 NSD1 CHD7 SNRNP70 GTF2IRD1 TERF2 CCDC61 DDX5	3.06e-05	1287	87	17	int:MECP2
Cytoband	7q11.23	POM121 EIF4H GTF2IRD1 POM121C	3.98e-05	97	89	4	7q11.23
Cytoband	Ensembl 112 genes in cytogenetic band chr15q22	ZNF609 C2CD4B C2CD4A SMAD6	1.32e-04	132	89	4	chr15q22
Cytoband	Ensembl 112 genes in cytogenetic band chr7q11	POM121 EIF4H AUTS2 GTF2IRD1 POM121C	1.91e-04	271	89	5	chr7q11
Cytoband	15q22.2	C2CD4B C2CD4A	1.46e-03	29	89	2	15q22.2
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	SPTBN4 MEGF8 NUMBL WTIP DMPK SNRNP70 CCDC61 PRX	2.23e-03	1192	89	8	chr19q13
GeneFamily	PDZ domain containing	DLG5 ARHGAP23 DVL2 PRX MAST3	9.75e-05	152	55	5	1220
GeneFamily	PHD finger proteins	BAZ2A NSD1 FBXL19	2.60e-03	90	55	3	88
GeneFamily	Ataxins\|Trinucleotide repeat containing	NUMBL TNRC6C	2.61e-03	25	55	2	775
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	SPTBN4 SH2B3 ARHGAP23 OSBPL10	3.55e-03	206	55	4	682
Coexpression	PEREZ_TP53_TARGETS	ORAI1 DLG5 HIC1 EPPK1 SH2B3 ARHGAP23 C11orf96 FBXO41 AUTS2 PIDD1 EML1 TNRC6C ADCY1 PRRC2B SMAD6	1.03e-05	1201	88	15	M4391
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D231\|Adult / Lineage, Cell type, age group and donor	C2CD4B ARHGAP23 KHDRBS2 EML1 HSPA12B PRX SMAD6	4.22e-08	167	88	7	5af9127bae05768a5164d5708a4ad37edca99324
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate\|5w / Sample Type, Dataset, Time_group, and Cell type.	DLG5 MEGF8 C11orf96 AUTS2 TNRC6C PRRC2B MAST3	1.45e-07	200	88	7	c92e4fc0442404481fcac623d691dae6215b852d
ToppCell	COPD-Endothelial-VE_Capillary_A\|World / Disease state, Lineage and Cell class	C1orf115 KHDRBS2 EML1 HSPA12B PRX SMAD6	1.61e-06	181	88	6	61608123959483ff60f07d8467996853c4371b6a
ToppCell	COPD-Endothelial-VE_Capillary_A\|COPD / Disease state, Lineage and Cell class	C1orf115 KHDRBS2 EML1 HSPA12B PRX SMAD6	1.77e-06	184	88	6	5f4f7775d488ececf086c71441defecbee9d8a9c
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDAN1 C1orf115 LIAT1 C11orf96 NOTCH1 SMAD6	1.88e-06	186	88	6	4ae3c0fe8640a8d029875cf3f0f5ffbba38e85f8
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	C1orf115 C2CD4B HSPA12B ADCY1 NOTCH1 SMAD6	2.00e-06	188	88	6	366a2d59b9c81d8a7659749f9c07efa46b49a39a
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN4 C2CD4B EIF4G1 C2CD4A DDX5 PRRC2B	2.00e-06	188	88	6	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	IPF-Endothelial-VE_Capillary_A\|World / Disease state, Lineage and Cell class	C1orf115 KHDRBS2 EML1 HSPA12B PRX SMAD6	2.07e-06	189	88	6	ea3aa3ef38f1d405bb527ae383cd12c551a3dd6f
ToppCell	IPF-Endothelial-VE_Capillary_A\|IPF / Disease state, Lineage and Cell class	C1orf115 KHDRBS2 EML1 HSPA12B PRX SMAD6	2.13e-06	190	88	6	b4e35cbfe4d43d2cd51f29c3085e4d9b1012e6f0
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN4 CABP1 TSPOAP1 FBXO41 SLC30A3 ADCY1	2.33e-06	193	88	6	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN4 CABP1 TSPOAP1 FBXO41 SLC30A3 ADCY1	2.33e-06	193	88	6	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN4 CABP1 TSPOAP1 FBXO41 SLC30A3 ADCY1	2.33e-06	193	88	6	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	LV-09._Endothelium_I\|LV / Chamber and Cluster_Paper	CABP1 TMTC1 MCTP1 EML1 HSPA12B SMAD6	2.63e-06	197	88	6	f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCell	390C-Endothelial_cells-Endothelial-A_(Artery)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	TMTC1 C1orf115 C2CD4B ARHGAP23 HSPA12B SMAD6	2.70e-06	198	88	6	f83956c4b13b5d0a0c6e3d9f580dbf99649ef175
ToppCell	390C-Endothelial_cells-Endothelial-A_(Artery)\|390C / Donor, Lineage, Cell class and subclass (all cells)	TMTC1 C1orf115 C2CD4B ARHGAP23 HSPA12B SMAD6	2.70e-06	198	88	6	5b5ccce5de82ea041465e656147cec3b8beb865b
ToppCell	Healthy-B_cell\|World / disease group, cell group and cell class	WTIP OSBPL10 SESN2 TNRC6C HSPA12B	1.06e-05	146	88	5	588359d3df6ad7090b7fa6c7f8d29cc1717e7f4f
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma\|TCGA-Breast / Sample_Type by Project: Shred V9	FAM193B HIC1 SNRNP70 HSPA12B CCDC61	1.42e-05	155	88	5	a4f2fffa8d0de760c556c3f8f1c91804eedbfa68
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 ARHGAP23 EML1 PRX SMAD6	1.60e-05	159	88	5	d3f81ba22160568ccaa6d2b04ebfd30630f9a6db
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	VWC2 TMTC1 C11orf68 FGF2 SMAD6	1.86e-05	164	88	5	3cd80e6275f0f9b5667912139d15ebf5e6b17f2f
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_2\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	FAM193B COL7A1 KHDRBS2 ARHGEF25 PRRC2A	1.86e-05	164	88	5	d7053de88ef8e42cac6726a40e72f212659ee034
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 MCTP1 FGF2 HSPA12B SMAD6	1.91e-05	165	88	5	a74751e0ec857aa974bec04ccc747c004a8f6e01
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 EML1 ADCY1 PRX SMAD6	2.15e-05	169	88	5	987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 ZNF219 ARHGAP23 C11orf96 EML1	2.15e-05	169	88	5	7c994653b0d629dfb046755d6b678452de0a15d2
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRIG3 COL7A1 NUMBL NEK8 ADCY1	2.21e-05	170	88	5	8465c3069bbc08705d070927e712b6bc85ac7c5b
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CABP1 IQSEC2 FBXL19 HSPA12B SMAD6	2.21e-05	170	88	5	55fe16d98ea284d05fb899888e4569c685644c7b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HIC1 CILP2 C11orf96 HHIPL1 ARHGEF25	2.27e-05	171	88	5	972fab891135bd755d5526cbc5a963200067b0a6
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D122\|Adult / Lineage, Cell type, age group and donor	TMTC1 EML1 HSPA12B PRX SMAD6	2.27e-05	171	88	5	bd20e85d36fa9d7ddc8afef6a1dea75efc9ee1dc
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HIC1 CILP2 C11orf96 HHIPL1 ARHGEF25	2.27e-05	171	88	5	2a77ed79c6f2e700e789c80451a70ecb31639719
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 EML1 ADCY1 PRX SMAD6	2.40e-05	173	88	5	afa6bb19df52541d8d17cbfac9cbdd18a5f3632d
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D231\|Adult / Lineage, Cell type, age group and donor	TMTC1 C2CD4B KCTD8 HSPA12B SMAD6	2.47e-05	174	88	5	2dd647c4fdf99fd1f7b838efef01baf2cbc3446d
ToppCell	droplet-Mammary_Gland-nan-21m-Endothelial-basal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN4 VWC2 COL7A1 SESN2 CCDC61	2.61e-05	176	88	5	27e5115fae5f0f63b333bc99fbf6a6d4c9182c46
ToppCell	Control-Endothelial_cells-Capillary_endothelial_cells\|Control / group, cell type (main and fine annotations)	KHDRBS2 EML1 HSPA12B PRX SMAD6	2.90e-05	180	88	5	b043f9ffb9a4cd427a15bebb86a711c7b08866e8
ToppCell	COVID-19-Endothelial_cells-Capillary_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	KHDRBS2 EML1 HSPA12B PRX SMAD6	2.98e-05	181	88	5	c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CABP1 LRIG3 KHDRBS2 SLC30A3 SORCS1	3.22e-05	184	88	5	6475a43201b136dcc9b113d2ca4cfa154ed9d65d
ToppCell	Control-Endothelial-VE_Capillary_A\|World / Disease state, Lineage and Cell class	KHDRBS2 EML1 HSPA12B PRX SMAD6	3.31e-05	185	88	5	a28187c2fd23564314b35759479ff2ca21f61485
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CABP1 KHDRBS2 SLC30A3 MAST3 SORCS1	3.48e-05	187	88	5	f18628ffc7ff7c762b8339ba8822cf0c3157f469
ToppCell	Endothelial-A-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	TMTC1 C2CD4B FGF2 HSPA12B SMAD6	3.48e-05	187	88	5	fd93f3f4b82dae3bf4eef245bfedc2a9e3251b61
ToppCell	Control-Endothelial-VE_Capillary_A\|Control / Disease state, Lineage and Cell class	KHDRBS2 EML1 HSPA12B PRX SMAD6	3.48e-05	187	88	5	54d7588172ac145ff5045ad9771636729ca3f0ca
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CABP1 KHDRBS2 SLC30A3 MAST3 SORCS1	3.57e-05	188	88	5	50c1b1d690f0e9443082f2adf4f1b8e9ce4cd337
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Adult / Lineage, Cell type, age group and donor	KHDRBS2 EML1 HSPA12B PRX SMAD6	3.57e-05	188	88	5	e5cad03f4a64147fe8174e7f614cf45233ffb9b7
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)-D122\|Adult / Lineage, Cell type, age group and donor	TMTC1 EML1 HSPA12B PRX SMAD6	3.57e-05	188	88	5	02a62888e9db29d20133eeca1686d302545a39c9
ToppCell	facs-Heart-RA-24m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWC2 CILP2 EPPK1 ADCY1 SMAD6	3.66e-05	189	88	5	e4efbb0733b382f4c855f6653dcddf36e0f8df28
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KHDRBS2 EML1 HSPA12B PRX SMAD6	3.66e-05	189	88	5	b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCell	COVID-19-Heart-EC_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CABP1 TMTC1 MCTP1 EML1 HSPA12B	3.66e-05	189	88	5	fe49852ba15f948b384d6b4c258927c70b741357
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CABP1 KHDRBS2 SLC30A3 MAST3 SORCS1	3.66e-05	189	88	5	a75226616340045b581d08429d2e123e041dee55
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BNIP5 TMTC1 KHDRBS2 KCTD8 AUTS2	3.66e-05	189	88	5	fcc3713e8200d51074f709f3360fb36efb0a639f
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CABP1 KHDRBS2 SLC30A3 MAST3 SORCS1	3.66e-05	189	88	5	c3df0e3c50af8f1cfb4d790e668bd7f42b276992
ToppCell	Endothelial-A-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	TMTC1 C2CD4B FGF2 HSPA12B SMAD6	3.76e-05	190	88	5	6e83fa0eb8cabe0ffb35375f16e6bf3755ec4977
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KHDRBS2 EML1 HSPA12B PRX SMAD6	3.76e-05	190	88	5	0e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KHDRBS2 EML1 HSPA12B PRX SMAD6	3.76e-05	190	88	5	0a351609a72fd638c84b2435782e312ee6a33aac
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CABP1 KHDRBS2 SLC30A3 MAST3 SORCS1	3.76e-05	190	88	5	49e09cdb843b3d889a06a811aa5affae68b25a75
ToppCell	Control-Endothelial-VE_Capillary_B\|World / Disease state, Lineage and Cell class	TMTC1 EML1 HSPA12B PRX SMAD6	3.85e-05	191	88	5	c672c8e28d06d555335976b3f8bd2ea6d3b34aae
ToppCell	343B-Endothelial_cells-Endothelial-B_(Artery)\|343B / Donor, Lineage, Cell class and subclass (all cells)	TMTC1 C2CD4B MCTP1 FGF2 SMAD6	3.85e-05	191	88	5	27a532a35d9e8822014f581fd56c4ca62e39f8fe
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KHDRBS2 EML1 HSPA12B PRX SMAD6	3.85e-05	191	88	5	f229abf69a1217194f74b0502486907e07dba989
ToppCell	Control-Endothelial-VE_Capillary_B\|Control / Disease state, Lineage and Cell class	TMTC1 EML1 HSPA12B PRX SMAD6	3.85e-05	191	88	5	322237793a1278bafb14e63cab688b353e352dcc
ToppCell	343B-Endothelial_cells-Endothelial-B_(Artery)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	TMTC1 C2CD4B MCTP1 FGF2 SMAD6	3.85e-05	191	88	5	1dfcff08e01e6a695953334342bcfde04ba005ad
ToppCell	PBMC-Severe-cDC_0\|Severe / Compartment, Disease Groups and Clusters	TMTC1 TBC1D30 DOK3 DMPK PRX	3.95e-05	192	88	5	4f4774b925058191673b4ba4b4d05b8b37f61795
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-SVEC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TMTC1 C2CD4B MCTP1 ARHGAP23 C2CD4A	3.95e-05	192	88	5	c3dda7c48732b0b8bde36de282d64192f5e9b98f
ToppCell	droplet-Pancreas-Endocrine\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C2CD4B DDX17 EIF4G1 DDX5 PRRC2B	3.95e-05	192	88	5	0dfd1e9896c34aee0f842f8de5d0e3af62a15f68
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TMTC1 EML1 HSPA12B PRX SMAD6	4.05e-05	193	88	5	f582e939e3e08a8a3f71deec78c33715be8faa51
ToppCell	Adult-Endothelial-capillary_endothelial_cell_(Cap1)\|Adult / Lineage, Cell type, age group and donor	TMTC1 EML1 HSPA12B PRX SMAD6	4.05e-05	193	88	5	39c6c96a2a100b1b290a779d36cc6bc17245720b
ToppCell	tumor_Lung-Endothelial_cells-Stalk-like_ECs\|tumor_Lung / Location, Cell class and cell subclass	TMTC1 C1orf115 C2CD4B HSPA12B SMAD6	4.05e-05	193	88	5	21fec35587ffb5c0157e54a821ce3ffd3e24e536
ToppCell	Control-Endothelial-VE_Arterial\|World / Disease state, Lineage and Cell class	TMTC1 C2CD4B ARHGAP23 FGF2 SMAD6	4.05e-05	193	88	5	52c0f2c7af57436f23e0c0e0c87086c47695e2c4
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 MCTP1 FGF2 EML1 HSPA12B	4.05e-05	193	88	5	6a623acd1adad9a78eddc32ffedb16352ad3fdfa
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 MCTP1 FGF2 HSPA12B SMAD6	4.05e-05	193	88	5	0b328f725f6feba263783eaca60c142e80df90f3
ToppCell	RV-09._Endothelium_I\|World / Chamber and Cluster_Paper	CABP1 TMTC1 MCTP1 EML1 HSPA12B	4.05e-05	193	88	5	e3fa47e2c7cd8a5b69186711c57751f2296de8ae
ToppCell	RV-09._Endothelium_I\|RV / Chamber and Cluster_Paper	CABP1 TMTC1 MCTP1 EML1 HSPA12B	4.15e-05	194	88	5	7b408096e717f2327c12aea35a8d5fc4621d3b06
ToppCell	(6)_Endothelial-B_(Artery)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	TMTC1 C2CD4B FGF2 HSPA12B SMAD6	4.15e-05	194	88	5	0cf4e67d4024652794b5bfdd4a71a7d98900b4c8
ToppCell	LPS-IL1RA-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TMTC1 MCTP1 EML1 HSPA12B PRX	4.15e-05	194	88	5	43f92b0533e26633dc94cce554045d641ef8fd76
ToppCell	LPS-IL1RA-Endothelial-Endothelial\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TMTC1 MCTP1 EML1 HSPA12B PRX	4.15e-05	194	88	5	1d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 EML1 HSPA12B PRX SMAD6	4.25e-05	195	88	5	23ced69fd904f1d4114b1a7f99f4b5f65ea8824b
ToppCell	Control-Endothelial-VE_Arterial\|Control / Disease state, Lineage and Cell class	TMTC1 C2CD4B ARHGAP23 FGF2 SMAD6	4.25e-05	195	88	5	56c66a3655820961e1390b8f4bcc5618e8d0c5a8
ToppCell	LV-09._Endothelium_I\|World / Chamber and Cluster_Paper	CABP1 TMTC1 MCTP1 EML1 HSPA12B	4.25e-05	195	88	5	19e0a6c3eae1615aaa39767300acd937dfcb2a7f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CABP1 C1orf115 KHDRBS2 SLC30A3 SORCS1	4.25e-05	195	88	5	787e95fb59c40bba784544b662fac37606ae1427
ToppCell	Children_(3_yrs)-Endothelial\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TMTC1 EML1 HSPA12B PRX SMAD6	4.25e-05	195	88	5	094cf6591daa5ffad36e44122b6f524a3a34c2fd
ToppCell	ASK454-Endothelial\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	TMTC1 C1orf115 C2CD4B HSPA12B SMAD6	4.36e-05	196	88	5	14dd6956ef420b660be0baf52a66960e57d75d16
ToppCell	ASK454-Endothelial-Endothelium\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	TMTC1 C1orf115 C2CD4B HSPA12B SMAD6	4.36e-05	196	88	5	2b777a2026b56839112fd179f2db482c49f4594a
ToppCell	nucseq-Endothelial-Endothelial_Vascular\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TMTC1 EML1 HSPA12B PRX SMAD6	4.36e-05	196	88	5	686533fd3fba8e4df96b9dd1307e870e89db4332
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 ARHGAP23 EML1 HSPA12B SMAD6	4.46e-05	197	88	5	cd509e49bbdbf991cc5913960ff3ef275ad40628
ToppCell	nucseq-Endothelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TMTC1 EML1 HSPA12B PRX SMAD6	4.46e-05	197	88	5	ebf9be068eaa658493fa7884fd19f34642922acb
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_vascular-VE_capillary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TMTC1 EML1 HSPA12B PRX SMAD6	4.46e-05	197	88	5	81718164c9802ee20c860ffbda7e62d5e9a76f16
ToppCell	390C-Endothelial_cells\|390C / Donor, Lineage, Cell class and subclass (all cells)	TMTC1 C2CD4B ARHGAP23 HSPA12B SMAD6	4.46e-05	197	88	5	aa381acea0f7882d39435a6f713386bf0588b5f8
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CABP1 WTIP C11orf96 DMPK ARHGEF25	4.46e-05	197	88	5	470e23dee4ca35e1fd021b7cdd58fcbc90639837
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	C1orf115 NUMBL AUTS2 CHD7 EML1	4.57e-05	198	88	5	6d12ecaa9532c134d9c4562534dcb59a6420b4d3
ToppCell	Tracheal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_pulmonary_venous\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TMTC1 HIC1 C1orf115 PRX SMAD6	4.57e-05	198	88	5	6fd984da5d2c419aeb34c8cbd8a00440e2f820a5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 EML1 ADCY1 PRX SMAD6	4.57e-05	198	88	5	92416e65a0dc1a4bf931833407620ea05d362f56
ToppCell	5'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMTC1 MCTP1 ARHGAP23 FGF2 SMAD6	4.57e-05	198	88	5	8a55589b9244283e4b0b423a4a6d6202e8e0fec9
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like-IPs_and_early_cortical_neurons\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	C1orf115 NUMBL AUTS2 CHD7 EML1	4.57e-05	198	88	5	7943e4f67c3d6efb5c8b00aa0ff3cfe7be10c48d
ToppCell	Bronchial-NucSeq-Endothelial-Endothelia_vascular\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TMTC1 EML1 HSPA12B PRX SMAD6	4.57e-05	198	88	5	a1ccbf0e653b2dd665c2254920eb9b37243cc0bd
ToppCell	5'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMTC1 MCTP1 ARHGAP23 FGF2 SMAD6	4.57e-05	198	88	5	58508a8df2714d769f137794c29441a7bd38b350
ToppCell	Parenchyma_Control_(B.)-Endothelial-TX-Endothelial-2\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	TMTC1 C1orf115 C2CD4B HSPA12B SMAD6	4.68e-05	199	88	5	523e01f6a0abd9820697572e042a381aae8932dc
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-2-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TMTC1 C1orf115 C2CD4B HSPA12B SMAD6	4.68e-05	199	88	5	0d0d5cb821db16514192ad536849a8a04e22e637
ToppCell	Parenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KHDRBS2 EML1 HSPA12B PRX SMAD6	4.68e-05	199	88	5	dc88ce36cc066eb6c28cfd5b9b60fe07f8cc7b53
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Smooth_muscle-2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	CABP1 VWC2 WTIP C11orf96 ADCY1	4.68e-05	199	88	5	2c5ad62919c64ea0242e0984bb9932d2d975f4e3
ToppCell	Tracheal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TMTC1 HSPA12B NOTCH1 PRX SMAD6	4.68e-05	199	88	5	fff88d2bba262583bb726900ae01e44954b72eb9
ToppCell	Lung_Parenchyma-Control-Endothelial-Endothelial-Endothelial-2\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	TMTC1 C1orf115 C2CD4B HSPA12B SMAD6	4.68e-05	199	88	5	dfd60380a29f99e187050933ee5252ec11c68a32
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	SPTBN4 C1orf115 ARHGAP23 FBXO41 ADCY1	4.79e-05	200	88	5	61d7dd0a78942b069c3f5e75044368dc00e6e8e6
ToppCell	Neuronal-Excitatory\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CABP1 KHDRBS2 SLC30A3 MAST3 SORCS1	4.79e-05	200	88	5	4409065bc7aa995354c71e0f9d6f3726cf393d6b
ToppCell	Lung_Parenchyma-Severe-Endothelial-Endothelial-Bronchial_vessel-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TMTC1 C1orf115 C2CD4B MCTP1 SMAD6	4.79e-05	200	88	5	c55efd997392e99068b673542f56f1a209c5a6c8
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 EML1 HSPA12B PRX SMAD6	4.79e-05	200	88	5	ced14d83222dbebca85c40540e76824e683354f3
Drug	Tiratricol, 3,3',5-triiodothyroacetic acid [51-24-1]; Up 200; 6.4uM; MCF7; HT_HG-U133A	CABP1 ZNF609 DDX17 SH2B3 BAZ2A PIDD1 DMPK PRRC2A	9.22e-07	198	87	8	7011_UP
Drug	Delsoline [509-18-2]; Up 200; 8.6uM; MCF7; HT_HG-U133A	POMT2 CABP1 COL7A1 MEGF8 BAZ2A IQSEC2 KHDRBS2	1.06e-05	197	87	7	7212_UP
Drug	Hydroxytacrine maleate (R,S) [118909-22-1]; Down 200; 12.2uM; MCF7; HT_HG-U133A	POMT2 COL7A1 DLG5 ZNF609 ZNF747 PIDD1 SMAD6	1.10e-05	198	87	7	3292_DN
Drug	trifluoperazine dihydrochloride; Down 200; 10uM; HL60; HT_HG-U133A	TBC1D30 BAZ2A PIDD1 CHD7 SNRNP70 PRRC2B MAST3	1.17e-05	200	87	7	1165_DN
Drug	Puromycin dihydrochloride [58-58-2]; Down 200; 7.4uM; HL60; HT_HG-U133A	TBC1D30 DOK3 EIF4G1 FBXO41 ZNF747 PIDD1	5.36e-05	173	87	6	2448_DN
Drug	retinoic acid; Down 200; 1uM; MCF7; HT_HG-U133A_EA	C1orf115 EPPK1 BAZ2A EML1 GTF2IRD1 ADCY1	7.77e-05	185	87	6	1049_DN
Drug	Acacetin [480-44-4]; Down 200; 14uM; MCF7; HT_HG-U133A	POMT2 DDX17 DVL2 AUTS2 EML1 MAST3	9.53e-05	192	87	6	6044_DN
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A	DLG5 DOK3 EIF4G1 DVL2 ZNF747 PIDD1	9.53e-05	192	87	6	2450_DN
Drug	Chlorpromazine hydrochloride [69-09-0]; Up 200; 11.2uM; HL60; HT_HG-U133A	DLG5 TSPOAP1 BAZ2A IQSEC2 NSD1 GTF2IRD1	9.80e-05	193	87	6	1864_UP
Drug	Tocopherol (R,S) [10191-41-0]; Up 200; 9.2uM; MCF7; HT_HG-U133A	DLG5 ZNF609 BAZ2A AUTS2 PIDD1 MAST3	1.01e-04	194	87	6	4961_UP
Drug	Nifedipine [21829-25-4]; Up 200; 11.6uM; PC3; HT_HG-U133A	ZNF609 ZNF219 EPPK1 BAZ2A IQSEC2 DMPK	1.01e-04	194	87	6	7303_UP
Drug	17-AAG; Down 200; 1uM; PC3; HT_HG-U133A	POMT2 EPPK1 SUN2 C11orf68 ADCY1 PRRC2A	1.01e-04	194	87	6	1226_DN
Drug	Acyclovir [59277-89-3]; Down 200; 17.8uM; MCF7; HT_HG-U133A	POMT2 DLG5 LZTS3 DVL2 EML1 MAST3	1.01e-04	194	87	6	5278_DN
Drug	Halcinonide [3093-35-4]; Down 200; 8.8uM; HL60; HT_HG-U133A	ZNF219 MEGF8 DVL2 ZNF747 NOTCH1 PRRC2B	1.01e-04	194	87	6	2185_DN
Drug	Megestrol acetate [595-33-5]; Down 200; 10.4uM; PC3; HT_HG-U133A	ZNF609 ZNF219 MEGF8 WDR33 IQSEC2 ZNF747	1.01e-04	194	87	6	6667_DN
Drug	Testosterone propionate [57-85-2]; Down 200; 11.6uM; PC3; HT_HG-U133A	COL7A1 IQSEC2 KHDRBS2 ZNF747 CHD7 MAST3	1.04e-04	195	87	6	4676_DN
Drug	Ivermectin [70288-86-7]; Down 200; 4.6uM; PC3; HT_HG-U133A	FAM193B DLG5 EPPK1 PRRC2A PRRC2B SMAD6	1.07e-04	196	87	6	2051_DN
Drug	Spiramycin [8025-81-8]; Down 200; 4.8uM; MCF7; HT_HG-U133A	COL7A1 BAZ2A SUN2 IQSEC2 PIDD1 DMPK	1.07e-04	196	87	6	3844_DN
Drug	Pheniramine maleate [132-20-7]; Down 200; 11.2uM; MCF7; HT_HG-U133A	ZNF219 BAZ2A IQSEC2 DVL2 FBXO41 PIDD1	1.07e-04	196	87	6	4130_DN
Drug	CP-944629 [668990-94-1]; Up 200; 10uM; PC3; HT_HG-U133A	COL7A1 MCTP1 BAZ2A IQSEC2 FBXO41 ZNF747	1.07e-04	196	87	6	7502_UP
Drug	Methacycline hydrochloride [3963-95-9]; Down 200; 8.4uM; MCF7; HT_HG-U133A	POMT2 ZNF609 DDX17 FBXO41 ZNF747 PIDD1	1.07e-04	196	87	6	4143_DN
Drug	Thalidomide [50-35-1]; Down 200; 15.4uM; MCF7; HT_HG-U133A	POMT2 ZNF609 EPPK1 DDX17 BAZ2A DVL2	1.07e-04	196	87	6	2258_DN
Drug	Chrysene-1,4-quinone [100900-16-1]; Down 200; 15.4uM; PC3; HT_HG-U133A	DDX17 LZTS3 NSD1 EML1 PRRC2B SMAD6	1.07e-04	196	87	6	7139_DN
Drug	Nalbuphine hydrochloride [23277-43-2]; Down 200; 10.2uM; MCF7; HT_HG-U133A	DDX17 TBC1D30 PIDD1 FGF2 DMPK PRRC2B	1.07e-04	196	87	6	2225_DN
Drug	Loxapine succinate [27833-64-3]; Down 200; 9uM; MCF7; HT_HG-U133A	EPPK1 LZTS3 SH2B3 DVL2 DMPK MAST3	1.07e-04	196	87	6	1516_DN
Drug	Pyrantel tartrate [33401-94-4]; Down 200; 11.2uM; MCF7; HT_HG-U133A	COL7A1 ZNF219 DDX17 TBC1D30 FBXO41 SLC30A3	1.10e-04	197	87	6	2260_DN
Drug	Flutamide [13311-84-7]; Down 200; 14.4uM; MCF7; HT_HG-U133A	COL7A1 ZNF219 WDR33 IQSEC2 DMPK MAST3	1.10e-04	197	87	6	3885_DN
Drug	prostaglandin E2; Down 200; 10uM; PC3; HT_HG-U133A	ZNF219 MCTP1 BAZ2A SUN2 PIDD1 EML1	1.10e-04	197	87	6	6547_DN
Drug	Perphenazine [58-39-9]; Down 200; 10uM; MCF7; HT_HG-U133A	ZNF609 SH2B3 BAZ2A ZNF747 PIDD1 SMAD6	1.10e-04	197	87	6	1540_DN
Drug	Androsterone [53-41-8]; Up 200; 13.8uM; HL60; HT_HG-U133A	ZNF219 LZTS3 FBXO41 ZNF747 FGF2 SMAD6	1.10e-04	197	87	6	1296_UP
Drug	Trimeprazine tartrate [4330-99-8]; Down 200; 5.4uM; MCF7; HT_HG-U133A	ZNF219 LZTS3 WDR33 SUN2 EML1 PRRC2A	1.10e-04	197	87	6	3478_DN
Drug	Methacycline hydrochloride [3963-95-9]; Up 200; 8.4uM; MCF7; HT_HG-U133A	COL7A1 MCTP1 TSPOAP1 BAZ2A DVL2 DMPK	1.10e-04	197	87	6	4143_UP
Drug	Cinoxacin [28657-80-9]; Down 200; 15.2uM; MCF7; HT_HG-U133A	POMT2 ZNF219 DVL2 ZNF747 EML1 SMAD6	1.10e-04	197	87	6	6257_DN
Drug	prochlorperazine dimaleate salt; Down 200; 10uM; PC3; HT_HG-U133A	DLG5 TBC1D30 PIDD1 PRRC2A PRRC2B MAST3	1.10e-04	197	87	6	1215_DN
Drug	Dextromethorphan hydrobromide monohydrate [6700-34-1]; Up 200; 10.8uM; PC3; HT_HG-U133A	COL7A1 ZNF609 DDX17 TBC1D30 FBXO41 FGF2	1.13e-04	198	87	6	6300_UP
Drug	Isradipine [75695-93-1]; Up 200; 10.8uM; MCF7; HT_HG-U133A	POMT2 DLG5 BAZ2A WDR33 PIDD1 SLC30A3	1.13e-04	198	87	6	6508_UP
Drug	Benzthiazide [91-33-8]; Up 200; 9.2uM; MCF7; HT_HG-U133A	POMT2 DLG5 ZNF609 KHDRBS2 FBXO41 MAST3	1.13e-04	198	87	6	4952_UP
Drug	Pirenperone [ 75444-65-4]; Down 200; 10.2uM; HL60; HT_HG-U133A	ZNF609 ZNF219 TBC1D30 LZTS3 MEGF8 WDR33	1.13e-04	198	87	6	2455_DN
Drug	Cefixime [79350-37-1]; Down 200; 8.8uM; PC3; HT_HG-U133A	DDX17 SUN2 ZNF747 PIDD1 FGF2 PRRC2B	1.13e-04	198	87	6	4567_DN
Drug	rotenone; Down 200; 1uM; MCF7; HT_HG-U133A	POMT2 MEGF8 DVL2 AUTS2 SLC30A3 MAST3	1.13e-04	198	87	6	5915_DN
Drug	SB 202190; Down 200; 1uM; PC3; HT_HG-U133A	DLG5 ZNF609 TBC1D30 DVL2 PIDD1 CHD7	1.16e-04	199	87	6	6882_DN
Drug	Terazosin hydrochloride [63590-64-7]; Down 200; 9.4uM; MCF7; HT_HG-U133A	ZNF609 LZTS3 BAZ2A ZNF747 FGF2 MAST3	1.16e-04	199	87	6	6092_DN
Drug	Cloxacillin sodium salt [642-78-4]; Down 200; 8.8uM; MCF7; HT_HG-U133A	POMT2 ZNF219 TBC1D30 ZNF747 PIDD1 FGF2	1.16e-04	199	87	6	2289_DN
Drug	Dihydroergocristine mesylate [24730-10-7]; Up 200; 5.6uM; PC3; HT_HG-U133A	CABP1 ZNF609 KHDRBS2 AUTS2 PIDD1 MAST3	1.16e-04	199	87	6	7275_UP
Drug	Artemisinin [63968-64-9]; Up 200; 14.2uM; HL60; HG-U133A	TBC1D30 NSD1 ZNF747 C11orf71 NOTCH1 SMAD6	1.19e-04	200	87	6	1714_UP
Drug	fullerene C60	ORAI1 COL7A1 TMTC1 ZNF609 ZNF219 TSPOAP1 BAZ2A OSBPL10 FGF2 EML1 GTF2IRD1 HSPA12B PRRC2A PRX PRRC2B SMAD6	1.57e-04	1498	87	16	ctd:C069837
Disease	glomerulonephritis	OSBPL10 PRRC2A	2.57e-05	3	87	2	MONDO_0002462
Disease	Aortic valve disorder	NOTCH1 SMAD6	2.57e-05	3	87	2	cv:C1260873
Disease	Aortic Valve Disease 1	NOTCH1 SMAD6	5.14e-05	4	87	2	C3887892
Disease	Aortic valve disorder	NOTCH1 SMAD6	5.14e-05	4	87	2	C1260873
Disease	Bicuspid aortic valve	NOTCH1 SMAD6	8.54e-05	5	87	2	C0149630
Disease	Aortic valve calcification	NOTCH1 SMAD6	1.79e-04	7	87	2	C0428791
Disease	Acute lymphocytic leukemia	SH2B3 NOTCH1	1.79e-04	7	87	2	C0023449
Disease	pulse pressure measurement	SPTBN4 LRIG3 HIC1 CILP2 MEGF8 C11orf96 HHIPL1 EML1 FBXL19 SNRNP70 ARHGEF25 TERF2 DDX5	2.14e-04	1392	87	13	EFO_0005763
Disease	urate measurement	TMEM11 SART1 COL7A1 C11orf68 NSD1 SESN2 ARHGEF25 SLC30A3 PRRC2B MAST3	3.04e-04	895	87	10	EFO_0004531
Disease	Thrombocytosis, Autosomal Dominant	SH2B3 FGF2	3.05e-04	9	87	2	C3489628
Disease	serum gamma-glutamyl transferase measurement	CABP1 DLG5 POM121 ZNF747 FBXL19 HSPA12B POM121C SLC30A3 PRRC2A MAST3	3.59e-04	914	87	10	EFO_0004532
Disease	abdominal obesity-metabolic syndrome (implicated_via_orthology)	DDX17 DDX5	3.81e-04	10	87	2	DOID:0060611 (implicated_via_orthology)
Disease	Thrombocythemia, Essential	SH2B3 FGF2	5.56e-04	12	87	2	C0040028
Disease	Williams-Beuren syndrome (implicated_via_orthology)	EIF4H GTF2IRD1	8.80e-04	15	87	2	DOID:1928 (implicated_via_orthology)
Disease	aspartate aminotransferase measurement	DLG5 CILP2 SH2B3 BAZ2A KHDRBS2 DVL2 NSD1 POM121C PRRC2A	1.39e-03	904	87	9	EFO_0004736
Disease	response to mitochondrial complex I inhibitor	VWC2 NUMBL	1.42e-03	19	87	2	EFO_0600033
Disease	heart failure	LRIG3 TMTC1 SH2B3 POM121C	2.22e-03	185	87	4	EFO_0003144
Disease	brain cancer (implicated_via_orthology)	NUMBL NOTCH1	2.67e-03	26	87	2	DOID:1319 (implicated_via_orthology)
Disease	alcohol use disorder (implicated_via_orthology)	DDX17 AUTS2 ADCY1 NOTCH1	2.68e-03	195	87	4	DOID:1574 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SSRESGRGSRGRGRP	CCDC61	316	Q9Y6R9
PEAGGLLSSRGRERR	ARHGEF25	366	Q86VW2
SIAAVPGRRGRRDGE	BAZ2A	1061	Q9UIF9
RGRDGEERGLSPALG	CABP1	166	Q9NZU7
LRRGPRGRGRTEGDE	C1orf115	16	Q9H7X2
GPVVRGEGASRRGRR	CHD7	2706	Q9P2D1
GPARERGGRGLEEGV	CDAN1	126	Q8IWY9
RSDGGAGRTGRPEER	DVL2	596	O14641
EGRTSKDSGEGPGRR	FBXL19	151	Q6PCT2
REGSFRLSGGGRPAE	NUMBL	221	Q9Y6R0
DRERGGSLRGGAEDP	NSD1	1071	Q96L73
EGPRTGLEASGRGRL	TSPOAP1	1456	O95153
GLEASGRGRLGPSRR	TSPOAP1	1461	O95153
RSRSRGRGDGQEAPD	PAGE4	6	O60829
DFLGGRGGSRPGDRR	EIF4H	161	Q15056
GGARRRGELPRDSRA	KCTD8	81	Q6ZWB6
SLLPGGSEGGRRRRE	NOTCH1	1651	P46531
GSEGGRRRRELDPMD	NOTCH1	1656	P46531
GDRARDEGARRQGPG	MCTP1	176	Q6DN14
PRGSGSGASRERPGR	LZTS3	71	O60299
FDRGDPSSGTGRGRL	HHIPL1	401	Q96JK4
LGRAGRSDSGGRGEL	LRIG3	21	Q6UXM1
GRERGSPSERCEERG	HIC1	346	Q14526
GSREEGTRRGPGCLE	IQSEC2	566	Q5JU85
SDRDRGRDRGFGAPR	DDX5	6	P17844
EGRGRDRGRLLGQGE	C2CD4B	341	A6NLJ0
GSRRSRRRSGDGEPP	ORAI1	26	Q96D31
DRERRSRGGLGAGAA	AUTS2	21	Q8WXX7
GDRGFGLVDVRGRRP	DLG5	901	Q8TDM6
SRRGRGRGALKSPEE	MEGF8	931	Q7Z7M0
ARGRLGRRDEDAGLP	NEK8	641	Q86SG6
AAGDRSAGPGRRGER	DOK3	111	Q7L591
ETGSRGALRLRGGAP	LCA10	21	Q71F78
RLGGEGPGAGDRRRE	HRES1	106	P13985
PGGGRLGERRSIDSS	HSPA12B	266	Q96MM6
PETRLGRGGAGDFRT	DMPK	321	Q09013
GERRRPIASVRDGRG	POM121C	11	A8CG34
PSSEDSRGGRRAPGR	POP1	821	Q99575
GERRRPIASVRDGRG	POM121	11	Q96HA1
GEPGGAERAAGTSRR	ADCY1	16	Q08828
LRSGEADLGPARRGG	BNIP5	191	P0C671
PGVDGRDGLRERRGF	C4orf3	6	Q8WVX3
SRPSGGAGRRERARA	FAM193B	6	Q96PV7
RGGDRGDRLDRARTP	EIF4G1	1166	Q04637
SARPEGGSGRGRRAE	FBXO41	521	Q8TF61
ERLDGEAGRRTRGPE	MAST3	1231	O60307
EERPSGSRLGDRGRG	FGF2	71	P09038
SEDSGRGRGIRGRGI	KHDRBS2	181	Q5VWX1
RGERGEPGIRGEDGR	COL7A1	2471	Q02388
PGGRRESNGDSRGNR	EML1	141	O00423
RGGGFGDRDRDRDRG	DDX17	81	Q92841
RGEGGGRSLPRSSLE	GTF2IRD1	106	Q9UHL9
ADEGGPRGRLRSRDS	HCN2	66	Q9UL51
EGRGRERGRLLGQGE	C2CD4A	346	Q8NCU7
RGSEGPRRGAGLSLA	PIDD1	761	Q9HB75
GERGSERGRDEARGG	SNRNP70	381	P08621
SGPGEEQRESRARRG	SESN2	26	P58004
PRGRRLGSTEEAGGR	TMEM41A	26	Q96HV5
TGREGTGEGRRRDKG	TNRC6C	411	Q9HCJ0
ERQRGTRPRLGFEGG	MRPL15	56	Q9P015
GGGLAESELRPRRGR	POMT2	6	Q9UKY4
EPAGGGRSREARSRL	SMAD6	151	O43541
VDSEGPARRGGAARR	TMEM229A	6	B2RXF0
EEREGGAAGPRGSRL	LIAT1	56	Q6ZQX7
PAGRGDGDSGRSQRE	EPPK1	3136	P58107
PAGRGDGDSGRSQRE	EPPK1	4201	P58107
ERVGPTSCRGRGRGE	PRRC2A	1016	P48634
SGGGGRRREPALEGV	OSBPL10	66	Q9BXB5
GFRREGSSGPRVRRE	CILP2	696	Q8IUL8
GRGARRPTRQREDGG	LINC00612	126	Q8N6U2
GGGAEPRQERSRARG	C11orf68	16	Q9H3H3
VRAESRRVDGGGRSP	C11orf71	61	Q6IPW1
GGRSPREPDGRGRSR	C11orf71	71	Q6IPW1
SREPGRRGADGDSSG	C11orf96	216	Q7Z7L8
GRRREEASTASRGPG	ZXDB	56	P98169
ELGRPARDEGGSGRD	VWC2	61	Q2TAL6
RRRLGPGSSGGSARE	TMEM11	6	P17152
SARGGGGDRTPSRRR	TMTC1	6	Q8IUR5
GGDRTPSRRRGCGLA	TMTC1	11	Q8IUR5
GEDLRVRRRRGTGGS	SUN2	96	Q9UH99
RRLARGRPDGEGAGR	ARHGAP23	1321	Q9P227
EGSGEGASGRRGRVR	PRX	1361	Q9BXM0
GEGRRGRRPGGLSVT	ZNF747	291	Q9BV97
VGGASGGERSVDRPR	ZNF609	1341	O15014
SGRGRGLREFARPED	PRRC2B	1106	Q5JSZ5
DGRAPGRDYRDTGRG	SH2B3	81	Q9UQQ2
PREGGEGGGSRRSRS	SPTBN4	2386	Q9H254
TGGGRPGLRTELEFR	TBC1D30	6	Q9Y2I9
EEAAGGGRGAEGRRR	TBC1D30	96	Q9Y2I9
GGSGGERRKRSRERG	SART1	46	O43290
SRERGGERGSGRRGA	SART1	56	O43290
VSPRDRGGAGGSLRL	SLC30A3	16	Q99726
GRRREEASTASRGPG	ZXDA	56	P98168
AGADGLSRGERGPRR	WTIP	61	A6NIX2
EAARGRDLRGRGRGT	WDR33	1141	Q9C0J8
GEGASRSPRGVLRDG	SORCS1	121	Q8WY21
RTGGGEGEDRRPRPD	nan	106	Q6ZS46
RKRPGREGGEGARRS	TERF2	26	Q15554
SPGRTLRNGRGGEAE	ZNF219	611	Q9P2Y4